skysight-inc/HackerNews huggingface dataset:
I apologise as my field is not related to proteins, but I do recall an interesting read about the subject from a few months ago. Here is the link if you wanna follow it yourself.

https://news.ycombinator.com/item?id=32262856

There are some interesting criticisms from the language, to the results, to the limitations of AlphaFold that I think seem to represent the prevailing opinion from biologists about the current scope of what ML can achieve on their field.

There is also push back to the complaints and some very optimistic people about Deep learning models on the field so perhaps you are right.
Chrome or Edge will end up their default browser in less than month through some tricky dark pattern.
There are no real pedestrians where I live and I have seen many lives lost to drunk drivers from car accidents. Please don’t drink and drive.
Ad hominem attacks then, rather than any actual rebuttal. What I'm hearing is "Alex De Vries is mean about Bitcoin so you shouldn't listen to him". Someone working for a central bank to me is someone who might know a thing or two about finance, rather than an enemy, but hey...

The thing is, I don't need to listen to him - there's tons of info out there about Bitcoin's presence in Kazakhstan from all sorts of sources. For instance here in New Scientist:

https://www.newscientist.com/article/2284222-coal-powered-bi...

Reuters reporting on energy problems in Kazakhstan due to mining there -

https://www.reuters.com/business/energy/crypto-boom-strains-...

About 20% of BTC hashrate seems to be there, and the energy there is 90% coal and gas. Then we have things like fossil fuel plants being brought out of retirement for Bitcoin mining in the US - https://www.voanews.com/a/bitcoin-mining-power-plant/6273552...

Yes, I know that stopping methane escapes is definitely a good thing. There's no indication that this is happening on any scale, and the stories all talk about "enormous potential", and possibilities and projections. I hope it does become carbon neutral, that would be one less problem with it, but it's not there yet and handwaving away problems because you have a potential solution is disingenuous.
I do not. Not because I’m feeling lucky, but at the company I work at it seems impossible. We rush through prototypes, ideas and so on so quickly that there is no time scheduled for testing at all. Also, most projects either survive only for a year or so (for business reasons, not technical), or get milked without any changes until they die.

The only testing I do is manual devtime testing (partial sandboxed deployments mostly) and then in production. If something breaks, we just fix it, having alert bots and excessive logs to investigate. Again, it is a business decision that is above me, not a simple overlook. It actually works well and brings no substantial downtime or losses.

I think the differences between us and a regular software company are that (1) we move very quickly, e.g. some prototypes take 1 day, not a “sprint”, (2) we only support “main” workflow. There are no rarely used features which could stay under the radar in production or fail only for a quiet subset of clients. There is no “product” or a “site” in a usual sense, only infra, scripts, bots, services, data exchange.

I also try to write code as dumb as possible and always crash-only, because refactoring is the worst enemy in this situation. When code is dumb, it is easy to move parts around and apply incremental changes to production without stopping everything for a week.
Show HN: Pure Go Opus Audio Codec implementation
Efficient proprioception is useless if key behavioural incentives are misaligned with key aspects of the environment.

Humans are quite good at creating collective organisations that are delusional, even though some of those organisations have excellent information about the state of their environment, because the invented incentive structures for action favour simplistic short term "maximisation" of fetishised behaviours instead of optimisation for (even) the medium term healthy future. Resource allocation is still looking frighteningly suboptimal right now, and simply empowering that with a "smart" central AI bot following the same patterns probably won't improve much.

I'm skeptical about the human race getting past this. Humans want a lot of stuff, and are prepared to form huge organisations to get that stuff, without really thinking through whether they really need it, what the other impacts will be, or why they are even doing what they do.

What is the human race trying to be?

Why?

How does the pattern of incentives get aligned?

It seems like we only have the weakest responses to these questions right now.
Sahil tends to write these clickbaity Twitter threads. I find that I vehemently dislike this style of writing. I'd much rather read the source of the ideas[0] than someone's unoriginal take on them.

[0] https://waitbutwhy.com/2015/12/the-tail-end.html
Why Katalin Karikó and not Robert Malone? [0]

[0] https://en.wikipedia.org/wiki/Robert_W._Malone
An escrow service is a way to solve that problem without turning into Paypal. Of course the fees would likely be larger.
Awesome! Yes, I’ve wondered whether the very large surface areas of zeppelins could create opportunities. I mean, with solar power, you can have quite a bit of electrical charge on hand— and if there was a cheap & weight-efficient way to generate thrust over a large area, it could be rather powerful.

Consider writing open proposals. You have a great set of knowledge and ideas. It’s easier than ever to get illustrations that make it seem real. Thanks!
Those who implement the tools from the ad companies are responsible for their GDPR compliance - you don't get to offload the blame somewhere else.
If you don't pay your bills, people come and take your stuff. Then other people come and make you leave your residence.

Then you get to live in your car. Unless someone has come and taken that.
Yeah, but Plato, who knew him, did

I mean this quote isn't in Plato's writings either but still
I think you miss the point. Trite as it may be, it's not about owing your parents anything, it's about having little time left to spend with them, which is awful if you love them. If you don't want to see them this tweet is not for you.
That's not what I said.

I said that if an explosion similar to the Chelyabinsk meteor happened there I'd need _extreme_ proof that it wasn't a nuclear explosion.
If you get a chance, read more about how the i3 was produced. It was bigger than just building an electric car, it was about building cars sustainably while advancing some really cool tech. To this day, you won't find a carbon fiber chassis in anything under $250k. It was also neutered by US regulators who insisted that the "range extender" could only be used after depleting the battery which severely limits its utility. That's fixable with a $10 app.

The i3 was fantastically cool it just turns out that most people aren't willing to compromise anything for a car that's built sustainably. That's why the i4 is doing much better than the i3 ever did.
I don’t understand the issue. If you’re already using google pay, then google is a data processor for you and you should have already received consent.

This isn’t stripe doing this, rather it’s google doing it.
Oil & gas companies as well, for their drilling and prospecting simulations.
Intel Arc A-Series Graphics for Desktops
The Search for the Perfect Sound
I’ve been concerned about this.

My tech stack is built on various products, including no-code site building tools, and I believe these tools employ JavaScript/cookies at layers which are inaccessible to me. Some of these may cavort with GA.

How liable am I?
https://archive.ph/ouxtM
The point of the article is that it isn't clear and that it seems like the company has been caught red-handed in the past. What should anyone believe the company in the first place? It implies that it should be looked into more thoroughly, which I completely agree with.
I'm just amazed ads work at all. Anytime I receive an ad I didn't explicitly request, I boycott that company. I'd have hoped enough likeminded people in the world would naturally defeat the ad sector, but evidently I'm an outlier. I'll never understand why the average consumer rewards and reinforces ad spend
> eMacs

"emacs"
I feel confident in guessing that you don't have a family.

Working a regular 9-5 that pays me well is so much better than the stress and time sink of starting my own company. It's stable, it's easy, and it gives me plenty of time and money to spend with my family.

Not everyone searches for meaning in their work. I enjoy my day job, but my satisfaction in life comes from what I do off the clock.

My family is my legacy and my respect. IDGAF what my peers think of me - why does that matter? I get a raise based on performance each year, and that's enough for me.
https://en.wikipedia.org/wiki/Day-fine
They’re underprepared because they weren’t adequately prepared beforehand.
The article was implicitly including hydrogen derived molecules like ammonia, methanol or dimethyl ether under the same category as they become extremely viable even with current technology if you can get the hydrogen at 95% electric efficiency with $200/kW of capital.
Ultimately phosphate is going to have to be recycled or extracted from much less concentrated sources. The average abundance in the Earth's crust is 0.1%, so supplying current world phosphorus demand (about 22 million tonnes/year; equivalent to 50 million tonnes/year of P2O5) would require mining about 9 cubic kilometers of rock per year. Difficult but not impossible.
Not sure if Daniele Ganser the best source for this…
In other news, Apple lies about AppStore sales.
Anti-cheat is cancer and doesn't do much to prevent cheating anyways. The only way to prevent cheating is moderation, but that doesn't "scale" (even though every time you ban a cheater they have to re-buy the game and is actually a net plus)
“The thesis of an essay or writing should be like a power chord or ballad-it should be directly addressed early, often, and the more clearly expressed the better.”
> It's like "all lives matter". Nobody but psychopaths disagree so why do people bring it up?

I only have anecdata to go on, but in literally every case I've seen, the reason has been "because of (and in response to) someone else implying otherwise".
I mean if you don't know what it means you could ask? Or even google? Simply googling "office hours college" is enough to get:

"Office hours are times when you can meet with your professors and teaching assistants to discuss the material being presented in class or other."
> probably only worth getting if you're especially vulnerable

I also grew up in the US and came away with the exact opposite impression. Every year from when I was in grade school through university there was a massive push to get everyone to have the flu shot. I didn't hear the phrase "flu vaccine" but the reasoning was always exactly the same as for the covid vaccines: herd immunity, less chance of getting the flu, less chance of dying from the flu.

Now as an adult with no health issues, I go get my flu shot every year. Why not? It's free, it takes barely any time out of my day, and I'm less likely to die.
That's nothing...Tomeu Penya[7] sounds like American English whilst singing in Majorcan[3]

[7] https://en.wikipedia.org/wiki/Tomeu_Penya

[3] https://www.youtube.com/watch?v=F_-BU1BmxWY&list=OLAK5uy_nhG...
Someone else in this thread thought differently saying : "It's gotten brighter over even just the last 20 million years. The ice caps helped reflect nearly .39 of it, but soot and melting are lowering that. It's called albedo and that loss will dwarf the CO2 Heat trapping."

Similarly I found that in the geologically recent past, the ice–albedo positive feedback has played a major role in the advances and retreats of the Pleistocene (~2.6 Ma to ~10 ka ago) ice sheets and that the ice at the arctic is in fact not that negligible given the loss of it in relation to the much higher warming at the poles.

To what extent do you believe clouds contribute?
If you have ever done web conferencing, watched YouTube or played a video games you have probably used Opus. The Opus codec is what makes it possible to send/store audio efficiently.

I am so excited to share this. I have been working on it since June. It was a lot harder then I anticipated. I wrote about it in greater length on https://pion.ly/blog/pion-opus/

If people have questions about Pion, WebRTC or anything in the space would love to talk about it!
Proof systems like this need wider adaptation.

https://en.wikipedia.org/wiki/Day-fine

Far too often these fines are simply considered "the cost of doing business".

Worse, in many cases they agree to pay the fine without admitting guilt. It is almost like the government simply wants a cut of the action instead of discouraging it?
All extensions are different.

My extension (excluding NPM-dependencies) counts in at around 20k lines of TypeScript + various other resources. I think that counts as above average.

Granted, the background-page/worker portion of it was not the dominant aspect, and thus had less rewrites required than if things had been the other way around.

That said, migrating to V3 was way less effort than I thought it would be. I'm not saying it will be so for all extensions, but it was for mine, and it may be for others as well.

Basically I'm just trying to provide some additional perspective here besides the usual content-blocker perspective which so far has gotten 100% of the narrative. Note I'm in no way dismissing that concern, but I think having the entire conversation framed around those extensions only does not correctly represent the huge variations found across the extension ecosystem.
I found this video to be a bit eye opening as well: https://www.youtube.com/watch?v=JXeJANDKwDc

Somewhat along the same lines. I ordered one of the posters from the video (not sure I can link it here)
Pye Wacket: Lenticular Defense Missile
Should I know who that is?
What blows my mind is how bots even care about this stuff.

Back in 2009 I started my first tech startup with a friend. We crawled the net and stored the locations of and contents of online ads. Aside from the mistake that this actually costs a lot of money and we were too young to effectively raise money, we also made another mistake: Ads were about to get very dynamic. Not just ads rotating on a site, but search retargetting and hypertargetting were about to take off.

So I did what any reasonable founder would do after learning that the business just wouldn't work. I turned down a just offered $200k (huge at that time) and closed up the business.

Years later I'm learning that bots are still interested, and I suppose there is some signal here, but its minuscule compared to what was available back then. Plus, there are fewer and fewer out-of-app websites people spend there time on these days.

I dunno. I'm happy that startup never went anywhere. It would have sucked to be swept into the ad tech industry over the past decade.
> he just assumes…

He’s not assuming anything so much as writing for a target audience that perhaps of which you’re not a member.
Can you actually back up any of that, or is this just your personal feeling about "the youth"? And have you considered that we're not more emotionally fragile and underdeveloped, but that we are instead more aware of our emotions and psychology and willing to engage with that and our own needs instead of just repressing everything and turning into a bitter, hateful old person with a lot of toxic shit shoved into the back of their mind? And I don't even know what you could possibly be referring to with "understand complex situations less, and have a harder time in accepting reality" unless you're going for some transphobia and/or capitalist realism lol
My ex-wife just died because of cancer. It brought me very similar thoughts and hopefully a lesson. I've spent too much time in my life on virtually 'nothing'. I need to change it now. I feel big desire to live through the tiny moments which turn to be the most precious in life.
All the best to you all, good people.
I don't understand the love ( obsession ? ) in the West for "space" -- particularly in people living alone, and with the pervasive lack of housing, plus insane rent / mortgage / utilities costs.

I wouldn't change our tiny room ( and silent, polite neighbours ) in Tokyo for any villa in Europe or single family house in the US either.
Successful "conspiracy theories" work on unprovable grounds. The obvious ones like faking the moon landing are based on the principle that you can't prove some past event wasn't fake, as it is proving a negative and there is no need to shift anything: the possibilities are infinite from the start.

Now, not being provable doesn't mean either that it's a just conspiracy theory, as any successful conspiracy will have enough plausible deniability.

To me, the whole endeavour of trying to prove or disprove a conspiracy is a fools errand. You either believe it or not, and can have adiscussion about it, but there's no point in bringing in a scientific process for something that is not science at its core.
People abusing Twitter for long-form. Imagine if you saw a tweet like the following:

> I was out for a drink with a friend.

> We’ll call him George.

> As we settled in, George asked about my life and how I was feeling.

> At first, I gave him the standard response that we’ve all grown so accustomed to:

> “I’m good. Busy!"

> He stared blankly through my empty words.

Where's the info, it's just noise!

God, it even has Buzzfeed formatting...
Simple Presenter Pattern in Rails Without Using Gems
Little domino tile: following the end of WWII, the US installs terrorist cells in Europe in fear of a communist takeover

Big domino tile: Silvio Berlusconi becomes prime minister of Italy in 1994
Any "trojan horse" is a propaganda one. Kim knows exactly how they work, but the act of improving lifes of North Koreans via "western" act would undermine their own propaganda.

They will gladly starve their people if they can blame USA for that.
She’s not a criminal. She got paid to promote something and she did. Not disclosing it is an ethical dilemma and she’s paid in much more than she made.

Also, if you buy something just because a celebrity told you to, you have poor decision making skills and it’s worth your while to work on that.
As most people will - die without legacy and respect, because they are not a corporate overlord.

I guess.
Several months ago, many outlets were reporting Google was shifting focus with Stadia, turning it into a white label product where other companies could create their own cloud gaming services. I think this might be a more viable business model for them. Imagine a market where game companies like Rockstar, Capcom, Ubisoft etc have their own streaming game service products just like Netflix, Disney, Paramount, etc. You pay a monthly fee to access that studio's library. We may have seen the end of Stadia the retail product, but Stadia the platform will likely live on in another form.

https://www.datacenterdynamics.com/en/news/google-stadia-shi...
Fixed link: https://play.google.com/store/apps/details?id=com.machineryc...
Turkey’s inflation hits 83% as Erdogan vows to keep cutting interest rates
But what if you (the party who bans the cloud provider IP ranges) don't have a majority share of the market, and your bigger competitors don't block these ranges?

Then it would be easier to bot owners to just move onto your competitors, and you would have higher efficiency than them.
I didn't do the math on it, but I used to finish a book just because I started it and felt compelled to do so. Now, if I'm not enjoying the book after the first 25% of it, I move on to something else.
The fine is supposed to act as a deterrent, right?
A completely unrelated observation, but some countries actually fine based on a person's net worth.

Here is an example from Finland where someone received a 54.000 Euro speeding ticket: https://www.bbc.com/news/blogs-news-from-elsewhere-31709454
That's great. I thought I heard of colleges where the entire campus was on the Google stack.

Looks like University of Arizona uses it: https://it.arizona.edu/google-storage which has 50k students: https://en.wikipedia.org/wiki/University_of_Arizona

No personal familiarity with it at that scale, though.
> as long as it has modal editing

That's what Henry Ford could say.
Musk is a good example because he does many non-bullshit, but also his fair share of bullshit things.

Even if we drop the semi-religious way people speak of him, or even view him in the most uncharitable light, he has a ton of awe-inducing projects going on. At the same time, he seems to spend a lot of time getting embroiled in the most inane nonsense, to say nothing of his social media activity.
Love Paabos work, but spinning the work as giving “huge insights into human physiology” is a bit of a stretch. If the bar were insights in human physiology there would be a lot more people who have done more important work.
My response to everyone saying this must be the professor’s fault: I graduated right before the pandemic, so I don’t know how things changed during the last two years, but I do know that US college students at mid-tier universities are very bad at learning. If I saw a professor at my university take the time to think this hard about why students are failing so badly, then I would trust his performance over the students.

I would say about 85% of the classmates I had (again, right before the pandemic) were completely unwilling to put in any effort to learn whatsoever. It still makes me mad thinking how many students expected grades to be given for nothing. Most wouldn’t study more than 30 minutes for a test and expect to be given a B for “good job you took it” and then go complain in office hours when they failed. Davidson looks to be about the same quality as my university, so i expect their students are similar.

What happens to these 85% students after the pandemic? I suspect they got even more used to doing nothing and expecting a pass.

Please note, just like the professor points out, there are always a minority of students who are very good at learning, who are motivated to learn, and who excel in classes where 80% fail. If a class had 100% failure problem then I’d blame the professor.
science fiction from 100 years ago,
based on the author's observations of the switch from agrarian to urban/mechanized life (i.e. the start of the the epigenetic shift I referred to)
matches biological realities revealed over the last few decades (thank you E O Wilson)
https://en.wikipedia.org/wiki/E._O._Wilson

doesn't throw any light? Perhaps, thought of course that would depend on what spectrum of light one was sensitive to.

I, for one, have a hard time seeing ultraviolet. Unlike my friends the bees.
Agreed. Much easier to search Cognito than Azure AD EI :)
DME is a leading contender for e-Fuels. In particular, it is a great fuel for Diesel engines.

The technology for e-Fuels is related to methods used to make liquid fuels from natural gas and especially coal. The historically most used process is Fischer-Tropsch which produces hydrocarbon gasoline, diesel fuel and even edible fatty acids, but has horrific economics because reaction pathways that build up and break down molecules are closely balanced requiring a big machine machine to make a small amount of fuel. DME is a single entity that can be synthesized more efficiently.

The biggest problem w/ e-fuels though is that the market that needs the, the most is aviation but aviation is picky about fuel quality so they are insisting on FT chemistry as opposed to the single entity fuels (or simple blends) that are considered more viable for ground transportation.