skysight-inc/HackerNews huggingface dataset:
How, though? It's not like we've had the ability to diagnose the majority of these diseases in utero until fairly recently, nor have we the means to intervene, even now. CRISPR as a tool has existed for just over a decade, and we're still very far from the ability to reliably modify fetuses, even in lab animals, and it's been only possible for, what, 5 years now? Lab research did not stop after WW2, and even then we've barely gotten to this point. The ability to sequence the whole genome and find mutations for the major disorders is still a far off goal. The majority of disorders are now known to be polygenic, affected by hundreds of different gene variants, with each population group seemly affected by different groups of genes. Nor have we settled on a definitive group of gene variants that can reliably be identified to be deterministic of any widely distributed disorder, outside a small handful like CF and DMD.
How so? I see them cited everywhere, even in stuff like CNBC
I browsed /g/ as a teen, watched lain and everything, but have since decided to consciously distance myself from this culture, to a certain degree because there is a sort of implicit "sexism" (in some broader sense) that I don't feel comfortable with anymore. The longer I stay away, the more obvious things like the way they draw faces and bodies, the often infantilizing postures combined with a kind of sexualization is. Keep in mind that drawn images can easily exaggerate human features that are not healthy or even anatomically possible, but that still serve symbolically as sexual indicators. This has become worse and worse over time, because fan service is good advertisement for publishing houses. Take a look at https://en.wikipedia.org/wiki/List_of_slice_of_life_anime and compare how the style has changed since the late 90's up until today. I think it is a lot more homogeneous and the appearance is more formulaic. Part of this might be that computer animation is more common place, but the other one is that a sense of beauty has been reduced to a mathematical problem of relating various proportions. It is also because I was part of this culture, that I know there is an explicit and intentional sexual aspect to all of this.

Reflecting upon my own impressions and how these changed, I am more conscious of these points and find it hard to ignore them. Assuming that I am not totally mistaken, which of course might be the case, knowing that others don't see these things pains me. More so when someone like the author of the link publically stands by it.

But you are right though that not every image is like this.
You would have been an idiot not to at least refinance the ARM (if not get into a fixed) a year ago when rates were low. Check back in 5 years when those ARMs start resetting.
What’s the Deal with That Security Slot on Your Laptop, Anyway? (2021)
You have a point haha - but I had some portraits taken last year and after the fact I had to say "I looked like a fucking beluga whale" hahaha
Where do you live? I live in Santa Barbara, a notoriously expensive area, and our housing prices are dropping / housing on market for way longer. Not that it's a fantastic barometer but the monthly email from Zillow for our zip-code usually forecasts some outrageous 1yr growth figure (ex. forecasted increase of 15%) and yesterday the monthly email predicts a 1yr housing price decline of ~2%. Things move slowly in large assets. Hell, the dot com bubble and 08' housing crash both took over 2 years to unwind.
Has anyone tried running this with an AMD card on Mac? At first glance it's able to run on Metal (given the M1 compatibility)...
What is "funny" is that this view is held by two very different groups of people.

- Moralist conservatives which despise sex work and sex workers for ideological and religious reasons

- Progressives which think it's degrading and negative that somebody is forced to sell their sex to survive (which is a noble thought), and therefore think banning sex work will help that goal (we all know how that went wrt drugs...)
> Children are less computer-literate than ever.

Going back 20 years, I wouldve never guessed this would be the current state of affairs! As an industry we've succeeded in unlocking computing as a background enabler, but have utterly failed in making create-side computing friendly and accessible
Sounds like you're looking for a modern iPad, which is basically just a laptop without the laptop parts.
> I suspect if Apple really wanted to they would probably start to produce their products in two lines like Nvidia did, with cheaper phones produced on something like Samsungs 4nm and the higher end phones on TSMCS 3nm.

Wouldn't be the first time Apple has used multiple vendors for their SOC. The 6s for example had SOCs made by both Samsung (14nm) and TMSC (16nm).
That version looks much nicer too
This is not a good article, it confuses immutable with fixed size, claims primitives are stored on the stack but includes strings in that set, and then claims that V8 used to have a problem with cycles because it used refcounting????

Also I found the writing itself to be long winded and hard to read even without the many technical errors.
20 years ago, programming skills and access to Anime in Europe were highly correlated.

Back then, me and friends spent an insane amount of time on reverse engineering a Japanese file sharing app so that we could build our own server version (like Deluge nowadays) and then we built our own IRC server and our own XDCC download bots so that we could get Anime raws onto a university server and then recode them to make download over ISDN (64kb/s) feasible.

Also, a lot of the Animes featured socially awkward nerd guys who by accident stumbled into their own harem...

With that context, posters of Anime girls together with nerd stuff sold extremely well at Connichi (a big Anime convention in Germany). A friend of mine (who's now CTO of a C++ dev shop) even bought a wax printer so that we could make really high quality A3 posters.

So I guess it's an in-joke for Europeans born in the 80s.
That 40% rule seems nuts. Who is making $65k that can truly afford a $500k house?
> I have no idea who is buying houses at these prices, if it's not Blackwater-type firms.

US housing at 2% 15-year fixed is the biggest handout the world has ever seen. That's why Blackrock-type firms GOBBLED up real estate.

They were the first ones to back out when interest rates started going up.

They're not the ones buying.

I'm guessing the people who are buying are either 1) completely desperate, 2) oblivious, or 3) are willing to bet they'll have a chance to refinance at a much lower rate within a year or two and don't mind the extra carry-cost until then.
I don't care about the individual comment, I care about the pattern.

Given that your account has had such a clear pattern of posting religious flamewar comments* that we've had to warn you multiple times in the past, and given that you were resuming that pattern several times in the current thread, it seems natural to let you know that we need you to stop posting like this and if you don't we will ban you.

Re "facts": people repeat their favorite "facts" all the time to bludgeon the enemy side in whatever internet battle they're prosecuting, so the but-it's-a-fact defense doesn't hold much water. It's a red herring, which is why it's the most beloved response of trolls. If you or anyone wants more explanation about this, I've posted about it many times: https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu....

If you want to have repetitive internet wars on grand rhetorical subjects, please do it someplace else. We're trying to optimize for curiosity here.

* or whatever you want to call denunciatory generic rhetoric about religion that leads other users to respond in kind and produce dumbed-down, nasty, repetitive threads
You think AWS doesn't have enough lock-in now? And yet maximum profits come from keeping customers, not driving them away.

There's no such thing as a managed service so proprietary that it can't be essentially cloned by another provider. I remember people making the same claims about S3 long ago, and yet there are multiple providers of S3-compatible file storage services now.

Microsoft's Azure provides migration tools for people wanting to leave Amazon's AWS, and they are not alone.

Amazon tends to be (in my opinion) a few years ahead of everybody else, and different competitors focus on different areas of competition, but migrating away from AWS isn't really as hard as the "proprietary" label might make it seem.
South Stream Gas Pipeline
I think it's a confluence of a few things...

1) You lock your mortgage rate for 90 days, so 90 days ago rates were significantly lower. These will be rolling off soon and by early next year the prevailing rates will obviously be much higher.

2) People are paying points up front to buy down the interest rate.

3) Jumbo mortgages are still much cheaper than conforming (I think a full point).
Monitor your own network with free network flow analytics from Cloudflare
I don’t know anything about ARM, but is the IP ownership a big deal compared to the manufacturing?

My first reaction was to think I’d do everything possible to keep ARM as a domestic company, but does it even make a difference if they don’t actually produce (ex:) CPUs? I can’t run my workload on IP.

The expertise is worth something though. We’ve seen that in Canada with companies like Nortel. Once those companies are gone, the local expertise quickly follows and you become dependent on a foreign company, which is regulated by a foreign government, for part of your critical infrastructure. It’s extremely short sighted IMO and most people don’t even realize what’s being lost.
I hope you occasionally consider the opposite perspective. Starting with a predetermination of conspiracy is just as bad (actually worse, IMO) as starting with a predetermination of honest behavior.

Alex Jones used the same reasoning to declare the Sandy Hook shooting a false flag intended to move the conversation about gun control. I encourage you to watch the coverage of the ongoing hearing where the very real people who lost their very real loved ones are testifying.
programming/scripting skills came in really handy when evaluating mortgages and things of that ilk.

I'm not sure I could have done the same using Excel, and software doesn't seem to exist to make these calculations easy to understand.

That's to say: Thanks! We need this.
Every dollar you spend on an effort, moves you one decision token closer to achieving your goal.
Funny picture imagining blackwater kicking down some doors and becoming a landlord
> China has one formal alliance.

This is a geopolitical trope about 20 years out of date.
Don’t be surprised when dozens of African and Asian countries choose China over Western interests if push comes to shove.
A rogue CIA unit teaching Europe AND Russia a lesson.
Imagine two people. One person makes 50k the other makes 100k. Both have expenses for food, tech, schools etc at 40k. This leaves 10k vs 60k to spend on housing. >500% difference.
Maintaining servers? Nah, you deploy a container and don't think about it. ECS is completely free to use.

Anyway, you have a tiny on-demand business, as I caveated above. You could run it just fine on a nano ec2 instance if you needed, which is $2-3/mo.
Or to make up for the $834/month, you need another ~$25k of pre-tax income if you follow a 40% rule, ~$30k for 33%, or ~$50k for 20%.
> <100% pay differential between California and somewhere in the Midwest does not explain the >500% difference in housing prices

Curiously, 20% down implies 5x leverage. Not saying that's what's causing the difference. But in the weird way leveraged finance works, a <100% income difference can absolutely fuel a 5x asset price gap.
Lots of web host also have S3 compatible equivalent offerings. They typically market it as "object storage".
Go read Foucault's "A history of sexuality". He spends the whole world debunking the idea that the victorian's were especially sexually prudes.

He spends the majority of the work trying to figure out why modern people are still convinced that the victorian's were uniquely prudish. He thinks this belief is deeply connected to many other strange sexual beliefs.

I think Foucault is frequently overrated but at least volume 1 of a history of sexuality is pretty neat.
> to protect against abuse

I would actually be on-board with such things if this were against abuse but it's not -- it's preemptively assigning blame, since my copy of Firefox is not modified in any way except uBO but CF loves to captcha it. The other stories in every one of these captcha threads, and the majority of the CloudFlare announcements at all, demonstrate this isn't isolated to "oops, our bad" but a systemic problem

If I were DDoS-ing some site, I deserve every ban I get, but just browsing via the provided navigation links on the site shouldn't "pardon our interruption" or gatekeep
Not the poster, but I assume they mean in utero genetic screening (an unfeasible idea, nor currently possible for diabetes or the majority of disorders)
The latest Windows 11 update just switched the task manager to the new UI style with support for dark theme.
The reduction in air pollution from vehicles between 2008 and 2017 is estimated to have saved 30,000 American lives that year, while still killing about 20,000 and causing disease in many more.

And that's just more efficient ICE.

You could say, see cars actually kill twice as many people as I thought, we definately need to ban cars. Or you could say, we should be encouraging people to use smaller, safer, less polluting cars, and other modes of transport.
A lot of the time these are not bootstrapped buyers, but families with help from parents/inheritances etc. That's what you're up against.
Prostitution has been legal in Amsterdam since 2000, so a good percentage of the current sex workers were born into that world. Has someone done a case study on the long term effects?
Yes, sign-magnitude is the right terminology, my mistake, but too late to edit. As for two's complement, look at slide 18-19 from the link somebody produced below:

https://posithub.org/conga/2019/docs/13/1430-John-Introducto...
Just like with drugs, we see what prohibitionism brought us: it didn't solve the problems it set out to solve, and created new ones.
Correction to the minor correction, Blackrock, the asset manager/ETF provider, does not engage in institutional purchasing of SFH homes. For a little while BlackStone, the Private Equity firm, had an ownership interest in company that did this, but I’m not sure they still do.

https://www.blackrock.com/us/individual/insights/buying-hous...

Edited to change “ownership” to “purchasing”
According to the project page [1], WebGL. WebGPU is still in development, it's the successor of WebGL and not yet supported by stable browsers.

[1] http://www.continuation-labs.com/projects/d3wasm/
Not to pick on your quick example, but actually testing it, these two terms [1] [2] have nearly identical results. Top result in both cases is history.com, followed by wikipedia, and the next 4-6 results are the same but in slightly different order.

I think this is actually an example of the benefit of their AI. Despite the big difference in the "style" of phrasing (simple english vs more formally naming the subject noun), both seem to map to a very similar representation in their embedding space. I've run into frustrations with this myself, but for basic questions like this it seems like the search works Pretty Good.

[1] https://www.google.com/search?q=why+rome+fall&oq=why+rome+fa...
[2] https://www.google.com/search?q=why+did+the+roman+empire+fal...
> The housing prices are delusional around here.

We had stupid cheap money with low interest rates and an increased demand for space for lockdowns and WFH. Of course prices went way up. The prices weren't delusional; they reflected market realities.
"That is NOT happening around here." Yet
I mean, sure, but if rates stay this high for even a year and half - prices are likely to drop substantially.

In that scenario, the real winners will be people who waited to buy.

I guess cash-buyers will do better than financed buyers - but both of them are going to do terribly if prices decline substantially.
~6 months ago, someone with a 90th percentile income could very easily afford a median priced home with a monthly payment well below $2k a month.

The answer to who is paying these crazy prices now is fewer and fewer people.
Swift Variadic Generics(a.k.a. Parameter Packs) Pitch
Christie’s Goes Fully On-Chain with New Ethereum NFT Marketplace
As someone new to python, I don’t understand this attitude.

I have decades of experience, having shipped code in swift, obj-c, Java, Scala, closure, ocaml, C, C++.

A few weeks ago I was asked to write something substantial in python. I have used python in the past for scripts of < 10 lines, so the syntax is not alien.

I have been extremely impressed by the experience. Async code just works and is very efficient. The match statement is very nice. Interacting with the OS is intuitive and well supported. I’m hard pressed to think of a language that would be more concise for what I’m doing.

I’ve had the same experience with JS recently too. It’s a good language now, and it decidedly wasn’t prior to ES6.

If I wind back 10 years or 20 years, there is just no way the languages as they were as capable as they are now. I can do much more with much less code.

The languages may be more complex, but they enable my code to be less complicated, and me to get more done.
Depends on the reality of the deal TSMC has with ASML - those machines aren't exactly quick to ramp up production of.
No. No. No. I need my numpad to be there on the side so I can type my 4 digit Windows password with it once a day :-)
The cycle begins again.
I go to Yandex for image search first, these days, especially if I want to do an image-based search. Whatever you may think of it, Yandex uses both facial ID and object recognition, and will return side-results that are both visually and semantically related to the uploaded image.

Google Images, on the other hand, seems to look for the nearest monetizable domain cued by the uploaded image, and gives you adjacent results about that. It certainly does no facial recognition, etc. (well, none that it will feed back to you in results, anyway).
You’re skipping the moral problem. The road to hell is paved with utilitarians.
Get notified when Congress trades stocks
Hi! First time poster, long time follower.

I wanted to share my app that we recently released.

LegislatureWatch tracks folks in congress and notifies you when they buy and sell stocks in the stock market. Our app provides a way for us to communicate to you that a trade was recently made. We show you all of their recent stock trades, dollar value of the trade, and when they made it. Some of our lawmakers are excellent traders.

This is our MVP release, so please be kind :) . Would love any feedback from you on what we should build next to make it more useful.

Thank you in advance!
I recall my parents being very proud of securing a 7% rate in the 90s when they bought our first home. That said, it was a very very inexpensive house compared to today's prices.
How's that different from refusing to work in a coal mine?
That same logic works up and down the line. If what you need is disk storage, then you are limited to dedicated hosts that provide something akin to S3. There are some! But that's also true when you want a database that isn't sqlite. Now you need a dedicated host that provides something akin to DynamoDB, and will manage it for you. Then you decide you need queueing, and you can either install and manage that yourself or look for a dedicate host that provides something akin to SNS/SQS. And so on...
That at least keeps up with current inflation. We'll see what inflation looks like in 2 years.
Thanks for your candour. For what it's worth I absolutely agree with you fundamentally there is no reason an EV shouldn't be able to make the million mile mark with only modest maintenance (perhaps having to replace individual components of the motors, perhaps a bearing for example). Fundamentally they don't have points of sliding friction, this makes wear and reliability much easier to achieve.

What impact this would have on the battery is an interesting question but with modern temperature control and BMS systems it may not even be a deal-breaker.
People, who always wear jeans and a loose t-shirt: Markdown on Github.
How are these firms able to buy at such low rates? I thought these loans were reserved for owner-occupied homes.
I am just waiting on the default templates to be added (credit cards, etc.) and I will be moving to it.
R2 is an object store. It is literally a drop-in replacement to S3.

Cloudflare is a CDN, which, like all of its competitors, is a lot cheaper than doing it yourself because CDNs are a competitive market. There are at least 10 (if not more) CDN providers out there that have footprints in several thousand datacenters, and the product is completely undifferentiated. In a competitive market, you have to charge related to your costs, because your competitors will cut prices to their costs.

In other words, in a competitive market, economies of scale get passed on to consumers. In monopoly and oligopoly markets, that is not the case.

Object stores are becoming a competitive market, with R2, B3, and Wasabi entering the game, but buying your own machines and using Ceph is still cheaper. You still pay for "value adds" like not having to manage the machines yourself.
Some thoughts about your onboarding:

> Try a Free Demo / NO EMAIL REQUIRED

Ok, sure! I’m assuming this is a demo of documentation created in Subsection, so I’m not sure who would expect it to require email anyway. Click

> Free Demo

> Email is not required to test Subsection!

> Start

Ok, an entire screen to say that again? There’s nothing to do on this screen, so it seems completely unnecessary. How can “no email required” be the most important information about the demo anyway? But sure, click

> Demo Created

> You can now create your very first guide!

> Next

Another screen that says nothing and where I do nothing? I don’t even know in what way a demo was “created”. I just want to see what the documentation looks like, but I guess this is a demo of an admin interface. There’s a slow video here showing me things I can’t do on this screen. Am I supposed to memorize what happens in the video to use on a different screen?

After this I get into the admin UI which seems straightforward - I didn’t play around much with it, but it doesn’t look too complicated. You should jump here in a single step after I click the demo button on the landing page!
Would you expand a bit on the fountain pens as a symbol of subculture/political stance? An otherwise well-adjusted friend of mine has been into fountain pens for a while and I would like to know more.
He's right you know.

We've waited long enough for the UK to come up with one for 40 years and the only one people can think hard enough of an example is ARM, which that has become a acquisition football by NVIDIA, Softbank and having the UK government getting involved in the ordeal. (No, Imagination Technologies is also gone before you mention that.)

So there are no credible candidates worthy for being a tech giant in the UK.
Hurricane Ian, Earthcam Naples, FL
IMO, this isn't a big deal. If you want rigorous error estimates, you need to use some form of interval arithmetic (or ball arithmetic). Also, these types of engineering and scientific work are pretty much all 64 bit, while POSIT is mainly useful for <=32 bit. My ideal processor would have 64 bit floating point (with Inf/NaN behavior more like posits) and possits for 16 and 32 bit.