skysight-inc/HackerNews huggingface dataset:
I'm not following several different aspects of your comment here. First of all, the paper is in Nature, not Science. Second, the first and second paragraphs do contain some relevant words, but nothing quantitative - literally the only quantitative number (not nomenclature number) in the entire first 2 paragraphs is CHIP being defined as >2% of something. Furthermore the reference to baseline genetic variation you mention is verbatim as follows: "Considering baseline genetic and extrinsic variability, the development of tools that permit the assessment of individual genetic susceptibility would improve risk stratification
and long-term clinical management."

And I would argue that the article (not paper) does _not_ convey the qualitative conclusion of elevated rates of nonstandard mutations, because it doesn't reference the baseline at all! It doesn't even present it as a comparison, like "We found MORE mutations in astronauts than would be expected of non-astronauts" - it literally just phrases it as "We found mutations in astronauts", which, considering that non-astronauts are exposed to radiation and get cancer + epigenetic mutations as well, doesn't differentiate it from the normal expected observation.
That sounds more like a case of "you're buying an app for our mainframes, so you'll need something to run it on".
After a certain amount of money to cover life expenses + recreation, additional money has diminishing returns. Once one reaches that point, leading a fulfilling life becomes the next highest priority. I would speculate the kind of person who joins an anti-abuse team would not find accepting hush-money about the lack of anti-abuse systems to be something they would find aligning with their vision of a fulfilling life.
According to congress.gov (the linked site), clicking on Actions shows zero activity since March of 2021.
We like to partner with current Airbnb operators and they also help facilitate the day to day management. There is a "Partner with Arrived" link on our header
Saying "blameless" overstated the case.

But the comment I was responding to said:

> ...what led to the 2009 financial crisis was mostly done under the Clinton administration...

That goes well beyond "Clinton doesn't get off Scot-free" all of the way to, "Clinton should get most of the blame."

I'm firmly in agreement that Clinton contributed. But I'm going to need serious convincing that what he did was more important than, say, failing to enforce regulations against fraudulent advertising on subprime mortgages. Or blocking the 2005 GSE reform bill which would have allowed more action before that problem blew out of control.
Your neighborhood didn't get a cat, you did. Your neighbors shouldn't be expected to take responsibility for limiting the damage your cat does.

The solution is not to make the world fit cats, the solution is for you to take personal responsibility for the animal you decide to host at your house. If you can't keep that animal at your house, then don't get an animal. It's simple.

Nobody would suggest if I buy a hyena that eats dogs that people should start putting their dogs in hyena proof armor so as to accommodate the preferences of the hyena owner and the inclinations of the hyena.
You're being uncharitable for no good reason. If you're not sure if your interpretation of what GP said is true, ask for clarification and stop at that. Your first paragraph is ok, the second was uncalled for.
I'll add to that the credit music: https://youtu.be/0GOA3kvP3Lg?t=3107. It fits the end of the game really well.
All the major frameworks require you to work off a foundation that's built for high interactivity, and I believe going with one of the major ones (except Angular) is still a good bet.

Technically you can use Vue as a library to add interactivity. It works ok, but you'll switch to compilation eventually.

Still in my opinion Vue strikes good balance between getting shit done and developer experience.

Svelte would be my next bet, I just don't have enough experience with it to recommend it.
(Attempting to speak from the Orthodox Christian point of view:) While we know some things due to divine revelation, there's plenty of truth to be discovered through the observation and contemplation of God's creation (both seen [the physical world] and unseen [logic, math, thought itself]). Whatever is true that comes out of Buddhism is true because it comes from God, it just comes by way of extraordinary insight, unaided (as far as we know, in the Christian tradition) by direct communication from God.
How to Tell If You’re Being ‘Quiet Fired’ (and Why That’s Nothing New)
You can compensate somewhat in the metadata but you still need to convince people to click and it's very easy to cross the line from clever but clear to punny and obscure. I imagine that if I looked through the current issue of The Economist, I'd find some clever headlines but it would still be pretty clear what the stories were about.

This isn't a new thing. When I was an industry analyst we also liked to do clever stuff in titles which at least one editor pushed back on. However, we were mostly a fully paywalled subscription so it was less of a consideration in our case.
The world's leading EV is angling to get into the lithium refining game
Zero based budgeting is the answer. But nobody wants to do it.
This sequence of comments is the JS ecosystem in a nutshell.

Hear about something new, then immediately hear about its multiple successors/replacements.
The Stanford Energy / Precourt Institute youtube channel has full 20 - 60 minute post-grad level presentations on a ton of stuff:
https://www.youtube.com/user/PrecourtInstitute

FWIW absolutely nobody would share your "this should be on individuals not policy" conclusion. They're quite explicit in stating the opposite.
The other big "hidden" subsidy is publicly-funded maintenance of tons of auto infrastructure like 16 lane interstate highways, sewer and water service to far-flung exurbs, etc. The automotive sector (auto manufacturing, petroleum, trucking, etc.) would probably not turn a profit at current levels of production if they were forced to pay for the maintenance of roads to a standard necessary for auto traffic. They might still exist but presumably without this artificial juicing of demand, it wouldn't have made sense to dig up so much oil (and produce and run so many machines to burn it) so fast.
While I don't think user payments would be enough to fund development, I don't think "they need Google's money" is evidence for it. It's not like paying for Firefox is currently an option.

Firefox is developed by the Mozilla Corporation. The closest thing to paying for Firefox is probably donating to the Mozilla Foundation, but that money is used for education and advocacy.
This is not necessarily a given, depending on the nature of the system, it absolutely requires evidence.

Does my circulatory system need to fully rest so as not to develop dysfunction?
> Every time someone trots out the false claim that it is a CEOs legal responsibility to maximize profits, I have to wonder about their ethical framework, as if maximizing profits is an inherent good.

The problem is that you're talking about how good people are, when other people are talking about how well things work, and about figuring out how to make them work better. Your ethical framework seems to be that people should be good and do good things, but with no reference to what things are good and what things aren't other than the intuition and improvisation of good people, and no reference to what we do if they don't do what we think are good things.

If you're relying on the CEO to be a good person, you've dismissed governance as a possibility and anointed kings. In general, I don't think that kings work in my best interest, so I prefer regulations.
Usenet? Mail lists? They were active and very useful 20 years ago, until spam invented.
Meta has already screwed up Facebook from a UI perspective which is 2D. It feels clunky and ugly in my opinion, and was better designed when it originally came out. Now they seem to be on the same path with their Metaverse apps - low quality Wii like graphics that feel 20 years old already.
"Individuals" don't build railroad networks, schools, bridges, etc. Individuals are never gonna build a nuclear power plant or get a person on the moon either
It's a bit ... presumptuous ... to assume that scientists that have been studying climate change for 4 decades never considered these possibilities.

In fact, a quick google search:
```
While sulfur dioxide released in contemporary volcanic eruptions has occasionally caused detectable global cooling of the lower atmosphere, the carbon dioxide released in contemporary volcanic eruptions has never caused detectable global warming of the atmosphere. All studies to date of global volcanic carbon dioxide emissions indicate that present-day subaerial and submarine volcanoes release less than a percent of the carbon dioxide released currently by human activities. [https://www.usgs.gov/programs/VHP]
```

Even if it were true that humans contribute less to global warming than scientists think, we should still try to decrease our overall CO2 output because it's still a contributor to climate change, albeit a smaller one, and the majority of processes that lead to us putting CO2 in the atmosphere are unhealthy in other ways. In the US 50% of greenhouse gas emissions are attributed to transportation and energy production. I think we'd all agree that burning fossil fuels is not great for our collective health and car/airplane exhaust fumes are full of stuff we don't want to breath.
I experienced the change of tides first hand. Without proper Senior Management support, you are essentially non existing, no matter how good you do.
The Stoics had plenty to say on what constitutes a good life. They might have also cautioned that a 'joyful' life may not be the same thing as a 'good' life, if that joy is derived from vice or a lack of virtue.

https://en.wikipedia.org/wiki/Eudaimonia#The_Stoics
Grug develop doctor's appointment website, grug use jQuery + Flask/Django.

Grug try develop Notion or Google Sheets competitor, grug use React/Vue framework.
Hmm, I haven't had issues with my Galaxy live buds. But you might be a heavier user?

The main annoyance is just that I have to re pair them to switch devices. But so far so good otherwise. I'm interested to see if they ever make a new version.
From: https://en.wikipedia.org/wiki/Wi-Fi

> The name Wi-Fi, commercially used at least as early as August 1999, was coined by the brand-consulting firm Interbrand. The Wi-Fi Alliance had hired Interbrand to create a name that was "a little catchier than 'IEEE 802.11b Direct Sequence'."

> The Wi-Fi Alliance used the advertising slogan "The Standard for Wireless Fidelity" for a short time after the brand name was created, and the Wi-Fi Alliance was also called the "Wireless Fidelity Alliance Inc" in some publications.

Elsewhere I've seen that it was chosen because of its similarity to HiFi - which is short for "High Fidelity" (regarding audio equipment):

https://en.wikipedia.org/wiki/High_fidelity

> High fidelity (often shortened to Hi-Fi or HiFi) is the high-quality reproduction of sound. It is important to audiophiles and home audio enthusiasts. Ideally, high-fidelity equipment has inaudible noise and distortion, and a flat (neutral, uncolored) frequency response within the human hearing range.

However, there seems to be a lot of debate as to whether the 'Fi' in WiFi was ever fully accepted to mean "Fidelity". So pretty much it seems marketing people liked the way "WiFi" sounded, so they used it.
What do you have against bikes?
I am actually not critical of the deductions.I never even considered bad intentions.

Being skeptical is required to get to reality. Do we really know if the storage procedures/ thawing procedures can't have a side effect of mutations on the samples? We are still learning too much about the epigenetics and we already know low temperatures can have adverse effects on tissues. So I just voiced my idea on this.
My first C compiler came out around then.
> There are many times me going ahead a bit to scout the trail and judge the impact of recent weather

I'm curious what you need to judge in advance that's worth getting beyond line-of-site of "newcomers"? I suppose if you're preparing routes which take time this makes sense but I'm struggling to think of examples.

Things change awfully quick and it's a nightmare when you lose a group member and have a vast and potentially densely foliaged area to search with rescue teams many hours from responding.

As long as everyone's aware of the situation and properly prepared then it's certainly their choice to make.
SPOILER

The first 31 were satire, the next 31 all HN.
I've updated my comment to reflect that I'm burned out on catching the flak, but not the work itself. Personally, I love basking in the zen of the simplicity! I used to be a professional web developer in a former life, but these days I'm more medical-device and embedded focused. I moved out of the web space around the time that AngularJS was becoming the hot-new-thing, for better or worse.
I've continued to code on my game submitted to the last WASM-4 jam for months and thoroughly enjoyed improving my messy game-jam code. So I'd disagree with the statement that Zig is only good for prototyping.
I am not a lawyer (don't want to get sued by California!) but the law has been super super fucking annoying to deal with while figuring out basic questions like, can I lend my personal money to someone, what counts as a finance fee in lending, does a subscription fee count as a finance fee, etc when exploring this fintech idea.

~100M Americans live paycheck to paycheck and unexpected expenses leave them to turn to expensive, predatory lenders or abuse the overdraft system. This is a real problem but solving has been a real pain.

Likewise, this DoNotPay guy is helping Americans solve a problem that's encountered by so many. Only reason people are getting screwed by Comcast, etc, is because the law is difficult to deal with.

Honestly, mad props to you, DNP guy. You are an American hero.
Fascinating how negative the comments are while this article made it onto the front page.

The votes are based on headline alone and the comments actually read it?
> Charging customers for nitrogen filled tires that contain no more nitrogen than air (hey 78% is a lot!)

Are dealerships claiming to use nitrogen and just pumping in regular air, or are you talking about the unnecessary upselling of it? It's common in racing to use nitrogen, but yea, totally unnecessary for a Camry or whatever. One of my cars displays a warning telling me to visit the dealer when the tire pressure is low because the manufacturer recommends using nitrogen. I laughed the first time I saw the message on my gauge cluster before I knew the reason...still a ridiculous thought going to the dealer to top off my tire pressure even for nitrogen.
We just posted our first Show HN ever with your exact same setup, but s/python/go. If you're running it in Docker, then this might work for you too:

1) CloudRun ( run a Docker container exposing a port to the web )

It can autoscale.

2) CloudSQL ( managed Postgres and some other SQL choices )

We faced some friction getting the two connected. CloudSQL is available on an IP address, then in our code we have PSQL library which we specify the IP address to. The complication was that CloudRun instances can't actually "see" the CloudSQL. After navigating the GCP documentation, website, and some trial and error, it magically worked.

It was painful to get setup but it's running smooth now.
> Also, why not get rid of farm subsidies

Most of farm subsidies that people talk about goes towards food stamp-type programs. Not wanting the poor to starve may be a good reason.

And when people talk about product subsidies (like corn subsidies) they are referring to the insurance system operated by the government. Due to the nature of what is being insured (i.e. something that is likely to affect most policy holders when disaster strikes), it is difficult for private business to provide the necessary insurance.

Traditional insurance products rely on only a few policy holders needing insurance each year. When mass disaster strikes, such as a hurricane destroying homes across a wide area, the government typically does step in to cover the difference. Since this is the norm for agriculture, the government stays at the ready. Farmers still have to maintain a paid policy to be participants in the insurance system.

Perhaps insurance should be abandoned, but it's generally considered a social good.
>Is this some kind of nihilistic moral relativism thing you’re playing at here? Otherwise I’m unclear what your point is.

I thought my point is obvious. I'm saying your descriptions are unconvincing.

The obvious path forward is to describe your "bubble" in further detail. What was the nobel prize for?

> A factor in my judgement about whether the people I’ve met who dwarfed me with their intelligence were actually intelligent? Yeah I’d say it’s a factor :).

I think this sentence shows you're unable to sense the implications of my statement. Why would I care about your judgement at all? Nobody cares, especially if we think you live in a <small> bubble. Does this clarify the next step? I'm basically asking for a more detailed description of your "bubble" so that I and others reading can make their own judgements about your bubble and the validity of your claim.

So far your arguments of "academia" and "nobel prize" are unconvincing to me. Is that not obvious? I thought it was, I guess I need to be more explicit next time.
FYI Similar messages here:
- https://www.atlassian.com/practices/open/research
- https://www.atlassian.com/practices/open#
Harvard biologist E. O. Wilson estimates that 30,000 species per year (or three species per hour) are being driven to extinction. Compare this to the natural background rate of one extinction per million species per year, and you can see why scientists refer to it as a crisis unparalleled in human history.[..]

https://www.biologicaldiversity.org/programs/population_and_...
I can't even parse this. My default interpretation is: "bad men gamble in the stock market and beat their wives." It seems like the article wants me to believe, negative returns are causing an increase in marginal wife beatings because of stress. Which I don't.
I'm sure you're doing whats best for the organization.
The changes took away from what made you unique, fun and independent.
> Let's see which one is leaner and more logical.

Leaner, yeah, I'm certain a vanilla app will produce less KBs. What about dev time? I've been writing JS since the late 90s and I'd never use vanilla for anything other than trivial projects, quick tests, etc.

More logical, that is 100% subjective.

> Ok, where is the cut off? What is the smallest app, where React will shine? And I never get an answer.

Of course you won't. It's an impossible question. Could you say with certainty at which point it's better to use or not use a framework? (any framework with any language) You can't.

Once you're deep into the swamp you may realize you should have used a framework... but it's often not obvious a priori.

> which use 70 files (without dependencies!)

Honestly that's kinda ridiculous. You could build a calculator with a single file and a couple of components. This is not a problem with using React or any other of the modern libs but with that particular programmer.
The real example for Nintendo going full lootbox was Fire Emblem Heroes. It’s a pure gacha game.

Actually viable at the highest end of competition (top tier all modes) as free to play, but has earned more revenue than not only every other Nintendo mobile game combined, but also possibly the entire 30+ year old Fire Emblem franchise.

To summon a hero at maximum competitive scoring capacity (11 copies) with cash on a focus banner was usually $650-750, bit more over $1000 for a Mythic or Legendary - but bad variance could easily double those numbers, if not triple them. But playing the game for free you earned about $175 of that currency per month. Moreover, the game now averages 11 new heroes a month. It launched with 90-something, but now has nearly 850 different heroes.

So if you ignored paying, saved your currency, understood the numbers and sat on your hands… you could be right at the top, spending your currency on exactly what you needed for score (and nothing else), and making meta-viable, sufficient scoring units out of the piles of 3 and 4 stars you’d be buried in. After that, play well and you’d be ranked in the same tiers as the biggest whales.

But the core monetization model (outside of newer reasonable cost subscription stuff) was basically evil.
I thought it was "charge your cars at night"
Most of these are not so much "subsidies" so much as normal bookkeeping practices as employed by the oil industry. Developing a new copper mine would count as an R&D expense, but not a new oil well.

Like it or not, the oil and gas industry are pretty dang critical to supplying strategic and economic needs of the US. Punishing them while still depending on them would be incredibly silly.

Addressing climate change is first and foremost a consumption problem. Addressing it in a supply-side, trickle-down method should be self-evidently counter-productive.
Cravings for fatty foods traced to gut-brain connection
> However, cloning Patreon isn't as trivial as it might sound

I imagine the non-trivial piece is adoption and normalization of the business model. Or do you mean that there is something technically difficult in what they are doing (which would surprise me greatly)?

Now that Patreon has normalized people donating on a subscription basis to content creators, that actually helps competitors.
I'm finding this argument unconvincing. Don't we have banks and insurance companies for this? Is it not the purpose of the capital market to evaluate large risky investments?
That’s the plan for trips to Mars. Water storage would be in a void between outer walls, creating a somewhat / partially protective barrier.
>> push people towards green energy

Not the poor. It pushes them further into poverty and closer to death.
We look for properties that are in high tourist and vacation destinations. With this model we think a lot more people can invest together, in some cases 500-1,000 in one property. Right now those same vacation properties are traditionally owned by one person.
Yep, Facebook incited genocide - not the actual people who made the posts - Facebook. Lay the blame at the feet of the perpetrators, not the makers of the tools they used. This is like blaming Mercedes for the holocaust because they made Hitler's car(s).
Some of these are pretty good. I'm impressed.
> "restrict the supply of energy."

use all the solar, wind, geo and hydro you want. even use as much nuclear as you want and build any nuclear plants that you can build cost competitively (but you probably won't be able to).

just stop using carbon-based energy.
My biggest problem with stoicism is that it teaches you to not worry about things out of your control, but doesn't give you the full toolset to actually make that happen. Those worries often take place outside of our conscious control, and we end up just building defenses on top of them to try to tamp them down, rather than addressing the underlying fears directly.

Maybe pure stoicism does actually give you those tools, but the modern "McStoicism" that everyone seems to go on about really feels lacking to me.
I stopped reading it years ago when it started getting gratuitously contrarian. After this reply from Chris I’m going to give it another go now.
> Sounds made up.

What sounds made up?

Also, related to nothing, why have a bunch of people on the internet started replying to everything over the past few weeks with "sounds made up"?