Warning, Long Post

There are a few things that you can do that are good for your mind before considering supplementation. These are really basic but most people do not follow them. I didn't till a few months ago.

Do you get enough water? About 2L a day is good for most people but is something to be modulated by your activity levels. Dehydration drastically degrades physical and mental performance (stamina, ability to focus, encode memory etc). As you get older you get less able to notice that you are thirsty.

Do you get enough sleep? It seems almost a matter of pride these days to boast about how little sleep one gets. But sleep continues to be important. There is evidence to believe that sleep aids in mental maintenance and the encoding + consolidation of memories - moving them from the lower level hippocampus to the higher level neocortex. Akin to transferring bits from high speed, throughput RAM to longer lasting but slower long term storage. If you are not getting enough sleep then you are impairing your ability to learn higher level abstractions and patterns.

Exercise - Everyone knows exercises is good for you. In addition to all the other cardiovascular benefits it is also good for your mood (opiates - yes opiates as in opium - such as endorphins get released) and memory. Exercise has been linked to neuron growth in the hippocampus and new nerve cell survival rates. As well as benefits to spatial reasoning and memory (makes sense).

Diet

This one is involved. But the greatest offenders are high Glycemic Index foods such as Refined grains and sugary food/drinks and hydrogenated fats. Other than the fact that providing nutrients to your body in a suboptimal way will reduce the performance of your mind and body and wanting to maintain a health weight, such foods have further negative effects. The brain does not store energy so low GI food that provide a more smooth delivery insure that your brain will have access to energy across the day. In addition, sugar spikes will result in a release of insulin to manage the glucose, antagonising further use by say your brain and thus making you feel tired and unable to focus. Constant Insulin and glucose spikes are no good in general though e.g. increased diabetes risk. Furthermore chronic high levels of blood sugar has been linked to memory, mood and attention disorders as well as nueroinflamation.

Do you know if your fatty acids balance is optimal? DHA in omega 3 is important for optimal brain function. http://en.wikipedia.org/wiki/Omega-3_fatty_acid#The_n.E2.88....

Adequate Choline intake? Choline is often not sourced at adequate levels despite being an important nutrient. It is also a precursor to acetylcholine which is involved in arousal, reward, attention and synaptic plasticity (in particular to do with learning).

Other minerals such as Magnesium, iodine and selenium have been shown to have a positive effect on mental health but are not sourced well enough in modern diets. Also indicated for energy and mental function are B Vitamins.

Other considerations

Think More - your brain is not some static rock. See nueroplasticity. Using your brain increases survival rates of new neurons. This stacks well with exercise, meditation and calorie restriction.

Did you know that your foods contain drugs (they obviously must if they are nueroactive). Eating foods that are high in precursors to certain monoamines - e.g. high in tryptophan or tyrosine etc. such as turkey, eggs, parmesan cheese may or may not have an effect - at the least they increase the bioavailabity of chemicals such as serotonin and dopamine. Also consider foods that interact with the GABA pathway for anxiolytic effects (various teas ++green) and a healthier way to achieve the so called Ballmer peak.

Reduced Calorie Intake - There is aging related benefits to this. But there is also evidence that it is neuroprotective as well as inducing nueron growth. This tricking the body to releasing stress proteins is well studied. You must come to your own conclusions.

Did you notice I sourced nothing here? This is because I don't want you to blindly follow my writing. I am not a medical expert and so I prefer you to search, do your own research and come to your own conclusions. I did leave search able key phrases interleaved through out.

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I don't take what people typically mean by drugs. But before going on I will ask you, do you know what you or I mean by drugs? When I say drugs I mean the stuff that is neurotoxic or prone to tolerance and or addiction (ethyl-alchohol, Tobacco: MAOIs in herbs + nicotine is culprit of addiction, MDMA, amphetamines, cocaine,heroin,opium, etc). I also have never taken the less harmful stuff like LSD or marijuana because they are illegal and hence not regulated. But more importantly I don't want to aggravate my chances of getting arrested by dealing with the people who typically deal such things. I also do not take marijuana beacause although it has been shown to be neuroprotective and anticarcinogenic it is also indicated in short term memory damage. And short term memory is strongly correlated to IQ.

When you say drugs you probably mean stuff that the government has deemed illegal and waging war on for whatever arbitrary reasons without thinking about what the term actually means. For me anything that is psychoactive is a drugs. So I am amused by the contradictions of people who say they don't take drugs while drinking beer or coffee, eating chocolate, eggs, meat or eating foods that are high in sugar (nueroactive by serotonin pathway amongst others).