skysight-inc/HackerNews huggingface dataset:
CRISPR/Cas9 PlatformCB provides an off-target prediction and analysis service for CRISPR/Cas9-mediated gene editing. With years of experiences, our scientists are expert in application of CRSIPR/Cas9 system. Our scientist team will provide reliable and professional off-target testing services for our clients. As a leader in gene editing, CRISPR/Cas9 PlatformCB offers trusted analysis results with high quality in a competitive price.
Try out Channels DVR [1] as your DVR server on a small server/NUC, and HDHomeRun Quattro [2] as your tuner.

It’s a great combo. ChannelsDVR Ad detection always finds just the right spot in my experience (UK, but heard the same from US friends).

One caveat with HDHomeRun is they had supply chain issues like everyone else recently so their may not be in stock or might be easier to find via Amazon etc.

1. https://getchannels.com/dvr-server/

2. https://www.silicondust.com/hdhomerun/
> he response time is just too quick for movies and video to appear natural

Sorry, what does this mean?

From my understanding (could be very wrong) when you playback video you just display every frame still for 1/framerate seconds. Why would response time affect it in any way, especially the bad way?
> is only effective with good targeting to the fitting users

This isn't true in my experience. When I was an affiliate marketer in a past life, it was extremely profitable to promote health and fitness products on generic search terms such as "basketball" and "football scores". User demographic data wasn't required.

Unfortunately, Google decided that they don't like affiliate marketers.
This is a neat project!

Thanks for the inspiration!
Plaid's times around the Nurb show that when weight gets solved with solid state batteries, which is what all the high end cars will use, ICE won't be competitive.

And while it's been a bit like fusion power, always a couple years away, enough is happening in solid state that it's probably happening in a couple years.

Now, it might now be competitive in the mass market, where I believe sodium ion and LFP/LMFP/etc chemistries will dominate for probably a decade, but it will own the 100k+ car segment.
Again, there is no value in "solving the long term storage problem". Nobody has any such problem. For reasons already explained several times.

The "largest project in the world" is, by definition, not representative.
Using Edge + adblock addon is like Firefox Focus.
This article entirely misses why this series of phones is named "Pixel". Pixel provides a top tier camera at a mid tier price
Halo's social features are core to its identity. CE, 2 and 3 were all designed as "an FPS party game". 343 really has no idea what makes Halo Halo. The entire design of Halo Infinite pushes you to NOT play with friends, what a wasted potential. Basically being forced to play solo to progress the battle pass instead of playing with my friends made me drop the game. Not launching with campaign coop was just absolutely boneheaded. Wtf is Microsoft/343 thinking.

At least MCC is good.
DjVu also contains text.

If your DjVu file contains an exploit for your DjVu decoder, even if you run it in a bombproof container, it could still conceivably inject malicious code into the resulting PDF file. That sounds far-fetched because the exploit payload would need to recognize that a PDF conversion was going on and respond by generating the PDF, but I remember when people thought exploiting buffer overflows was implausible, and this is not the same level of rocket science.
I think you would benefit from approaching the situation with a bit more understanding. Also forget Norway, America is a big a diverse country so that is your problem to solve. You are not competing with Norway, you are trying to solve your own problems and failing.
Did you have to do anything to make universal control work? I guess I just assumed that since it was a new feature all of my old Apple products wouldn't work (like my 2012 Mac mini that runs a family dashboard doesn't work with UC).
As another former music student turned engineer I think the breakdown comes from the misinterpretation of "rule" which could better be called "practice" or "style."

My barely-above-pedestrian take is that music theory is an analytical exercise that tries to separate order and patterns from the spontaneous discovery of what "sounds good" in a piece so that the practice can be reapplied to another. The rules of theory aren't really rules, they're a taxonomy of practices exercised by composers and musicians that came before us. And what works changes with the taste of audiences.

A great example to me is parallel octaves, fourths, and fifths. You would be hard pressed to find popular music composed in the 20th century that didn't make liberal use of those, and the technique for writing and playing them is so commonplace it makes no sense to call it a "rule" to avoid them.
Exactly. The author is living in a middle/upper class suburbian bubble. Bigger and bigger houses that consume more and more resources is a problem, not a sign of progress. It is a glaring sign of the consumerism and resource depletion that is fueling the crisis we're in.

There is no amount of renewable energy that will make "average homes are 2,657 square feet and have air conditioning" a sustainable way of living.
I've never seen a confirmation of this, but I always suspected the Tim and Eric "Prices" sketch to be a homage to Crazy Eddie's ads.

https://www.youtube.com/watch?v=hJ9yBgTp9UQ
This is a philosophical question, really. Is there ever true understanding, or just pattern matching? The Chinese Room thought experiment talks about this:

> Searle's thought experiment begins with this hypothetical premise: suppose that artificial intelligence research has succeeded in constructing a computer that behaves as if it understands Chinese. It takes Chinese characters as input and, by following the instructions of a computer program, produces other Chinese characters, which it presents as output. Suppose, says Searle, that this computer performs its task so convincingly that it comfortably passes the Turing test: it convinces a human Chinese speaker that the program is itself a live Chinese speaker. To all of the questions that the person asks, it makes appropriate responses, such that any Chinese speaker would be convinced that they are talking to another Chinese-speaking human being.

> The question Searle wants to answer is this: does the machine literally "understand" Chinese? Or is it merely simulating the ability to understand Chinese? Searle calls the first position "strong AI" and the latter "weak AI."

> Searle then supposes that he is in a closed room and has a book with an English version of the computer program, along with sufficient papers, pencils, erasers, and filing cabinets. Searle could receive Chinese characters through a slot in the door, process them according to the program's instructions, and produce Chinese characters as output, without understanding any of the content of the Chinese writing. If the computer had passed the Turing test this way, it follows, says Searle, that he would do so as well, simply by running the program manually.

> Searle asserts that there is no essential difference between the roles of the computer and himself in the experiment. Each simply follows a program, step-by-step, producing behavior that is then interpreted by the user as demonstrating intelligent conversation. However, Searle himself would not be able to understand the conversation. ("I don't speak a word of Chinese," he points out.) Therefore, he argues, it follows that the computer would not be able to understand the conversation either.

> Searle argues that, without "understanding" (or "intentionality"), we cannot describe what the machine is doing as "thinking" and, since it does not think, it does not have a "mind" in anything like the normal sense of the word. Therefore, he concludes that the "strong AI" hypothesis is false.

https://en.wikipedia.org/wiki/Chinese_room
Have you confirmed the physical location and applicable jurisdictions of the maintainers of those distros or why focus specifically on US law here?

I know the US is trying (and often getting away with) unilaterally setting rules on the global stage but let's try to not play along.
You can't do this in either PDF or SVG, except using JS, which many PDF and SVG viewers don't support.
Commercial displays are more like $700-$1000 in this size class, and power isn’t free, so there is presumably some crossover point in total cost of ownership.

I’ll gladly replace my menuboard 43” TVs with eInk displays if they ever reach the rough price neighborhood ($1500?) and have a single-digit-seconds repaint time
Every Mind Has Worth
In these dark times, we cannot discount any contribution.

Any voice of reason offering solutions for our suffering must be heard.

We are a world juxtaposed, and dying.

If you are a voice for life, speak!

Your position, gender, caste, or wealth bind you, then I absolve this imagined slight.

How shall we save our world? Tell us now.
Didn't know half-frame film cameras were a thing, really cool!

Here's a diptych of a salt mine I shot when I visited Peru: https://www.instagram.com/p/BsjB07glcXs/
Since CRISPR/Cas9 technology was applied for genome engineering, it brings a revolutionary development of genome-editing technology. CRISPR system makes it easy and efficient to make targets cuts to genome. However, it may induce cleave off-target DNA targets at low frequencies when applied for genome editing. To overcome this limitation, various methods have developed to detect these unexpected cleavages by scientists. Genome-wide Unbiased Identifications of DSBs Evaluated by Sequencing (GUIDE-Seq) is one of cell-based assays for off-target sites detection. This assay is an approach for global detection of DNA double-stranded breaks introduced by RGNs (CRISPR RNA-guided nucleases) and potentially other nucleases. It is highly sensitive and can detect off-target sites that occur at a frequency of 0.1% in a cell population. GUIDE-Seq is a recommended method to detect the putative off-target cleavage sites.
MS Teams video and voice doesn't work at all in Firefox. Google "gadgets" don't work in mobile Firefox unless you spoof the user agent. There are also a handful of other sites I've run into where certain functionality only works in chrome based browsers. Sometimes, spoofing the user agent is enough to get it working in firefox.
Sunk cost fallacy?
after 8 years as a nodejs developer, elixir's concurrency and parrallelism toolkit is lightyears ahead. sagas, promises, channels.. Its all a joke compared to what elixir offers.

Phoenix gives me a network synced crdta backed data structures, multicluster websocket support with long polling fallback, supervision trees with long lived processes and a descent pubsub system out of the box. we've gone 2 years in production and haven't needed redis or rabbitmq yet. its allowed us to focus on delivering features without drowning in infrastructure.
Unsafe rust has numerous safety checks above and beyond C++...
And 3% forcing is enough to cause cataclysm. Which gives us 100 to 200 years to get off the growth train. ie. we are exactly where we were WRT direct thermal forcing now as we were WRT GHG when the alarm first started being raised.

So when your rube goldberg plasma machine produces ten times as much heat as work then we need to end exponential growth before the transition happens rather than 50-10 years after and immediately replace it with solar. If it produces 100x as much heat as work, it's not even useful for that.

Luckily the process of extracting the energy and containing the plasma is so convoluted it's never going to be viable anyway even if the fusion step works.

Inertial confinement might result in a viable machine, but I'm not holding my breath
Who is going to rebut optimism? But only the part that needs a fair counterweight to it. Consider the evidence that life of all kinds thrives everywhere. It is its very purpose to thrive above all else, or it just ceases. Existence then, necessarily favours a force or direction for life to thrive, even just probabilistically. I would argue that these favourable odds for life to exist and thrive are indistinguishable from an intent for life, for you, to thrive. And this is the rational case for a divine intent. For you, as life, to thrive. Accepting this as an axiom of your existence is all anyone needs to experience the optimism described so well in the article. It's the funniest thing in the world to look back and be wrong about as well.
I have verified that ryu is a dependency of json_serde, which is a dependency of ripgrep. Apache-2.0 OR BSL-1.0 is indeed the correct license for ryu.

It is not included in the Debian copyright file. I suppose this is because the library is not included in the source package, and the BSL does not mandate notice preservation for a binary output. And Debian policy for the copyright file is that only notices or info that must be preserved are required to be present in the file.
Do you mind sharing what mouth appliance you are using?
> None of my customers have ever asked... Buy a license... Learn how to use a screen reader...

You might be overthinking it. Get a blind person/screen reader user to use your site to provide you feedback. It's the same as any usability study. Even if you did learn how to use a screen reader, you'd miss a lot of the nuance of using one. It's a lot of hot keys, jumping around the DOM, and switching between different input modes
I recently bought a used Samsung 50” plasma for like 60 or 80 bucks for the basement. Picture is excellent. Dude had never calibrated it though. Can’t believe he watched it for 11-12 years or whatever the way it was.

I also more recently got a C1 for the living room to replace a cheapy Hisense that started wigging out, and sometimes I think to myself that I should have saved xxxx dollars and just gotten another used plazzy off FB marketplace…
That is a good argument, I admit. At least for some contexts.

When I hear "customer" I just feel like we are always talking about exchange of money.
Because of cache locality issues, linked lists are a bad data structure for almost all purposes. A plain old vector, or maybe a VecDeque, wins for almost all workloads.

For the few times they are useful (e.g. if you're writing lock-free algorithms, you want a hard upper bound O(1) append rather than just amortized O(1) append, or you don't have malloc available), Rust is a fine language to write them in. But also there are plenty of high-quality libraries on crates.io, so you probably won't have to write your own.
I think a trend in contemporary theory is the understanding that western music study is a like a philosophy for how it's been taught and understood for a few centuries. There are a lot of composers that have outright rejected the practice to bring in influences and learn from other cultures in the last half of the 20th century, and more recently schools will teach students some pedagogy from other cultures or perform works from non-western composers as a means of exposure.

The kind of downside is that until the late 20th century, music education (including theory) was basically a master/apprentice relationship and even today we have a lot of that tradition baked into the formal study.
Do we yet know what the status of uBlock or a uBlock fork for Manifest V3 is? I know it won't be able to have all the same features, but it certainly will be doable, but have the authors fully set their minds up about not converting their extension? Has anyone decided to fork it and do it?

I don't really care about all the fight about Chrome vs Firefox, I just want to know if someone will port uBlock to MV3.
That's so much simpler and more achievable than using a solar panel instead and not wasting orders of magntude more energy than we need. Thanks
I usually prefer the scanned PDF in these cases, because the OCRed version often contains errors, and in cases where the book matters, those errors can be very difficult to detect (incorrect superscripts in equations and things like that). Sometimes it's so poorly scanned that I don't prefer the scan (especially a problem with scans by Google Books).
Ask HN: Are you going to quit?
September looks to be crunch time for (some, mostly big) tech companies looking to get people back to the office. Apple being the most notable to lay out the demand.

So... those of you working at companies demadning a return-to-office... are you going to quit?
62% of users are opting out of third-party tracking, according to https://www.cnbc.com/2021/11/13/apples-privacy-changes-show-....

That would be nearly 40% of users who are not hitting the 'Allow' button on the consent pop-over.
So which point are you making? Are you claiming

- “I’ve been there on the front lines for a whole long two years, and I’ve seen what the article is talking about! It’s even worse than you realize! If you treat these teachers like we have for a sustained period over this many years, the constant negative shit turns a sizeable amount of the teachers themselves to be crappy?”

Or is it

- “I don’t buy it. I did a stint for two years. That’s as good as those with 30 years. It’s their own fault because they’re mean and nasty.”

You didn’t make clear whether you were offering your exhibit of suffering as a commiserate symptom or an accusatory cause. Could you clarify please?
>And Albert Einstein only had pencil and paper!

And a slide rule, it's not like he needed to write every calculation.
America is big and diverse, but it is not a special snowflake. You are choosing to provide public schooling but failing to do so well. There is a myriad of reasons why and I am sure it is different per location but the fact remains. In your ideal private focused system, are kids not provided a good education when their parent's income can't keep up with the worsening class divide? If so, do you think that will result in a positive situation for America long term?

I do appreciate your perspective by the way, thanks for engaging.
This completely glosses over the rather gritty realities of how to sync data between devices. It's not easy and IME most people do an awful job because they think it will be.

The only thing approaching an off the shelf solution to this is the CouchDB replication protocol. While technically good, it suffers from a number of issues if you want to use it in practice:

- dearth of cloud providers for CouchDB

- There's pouchDB for the browser but there's nothing for native mobile clients

- While PouchDB is great, it has to run on-top of browsers IndexedDB implementation, all of which suffer from reliability and capacity issues
My usual heuristic is to take the version with the largest number of pages, or if there are several with the same number of pages, the one with the largest filesize. Obviously if someone is gaming this it won't work; it's trivial to insert mountains of noise into a PDF.
I believe speeding tickets are generally civil summary offenses. Criminal summary offenses are apparently even called "non-traffic summary offenses" in some places to distinguish them. Every speeding ticket I've ever gotten specifically noted that it was a civil infraction. When a police error resulted a summons for attaching license plates to a car they weren't registered to, the ticket in the mail specifically said it was a criminal infraction.
PDF also supports JBIG.
All countries have "staked their survival" on exactly what you describe for most of a century. Nobody seems exercised about it.

You are always free to invent falsehoods about pumped hydro, as about anything else.
I wonder if it's something like the default settings of Tor Browser already prevent some ads that uBO also would have blocked, so that just makes the numbers worse for uBO, even if the user isn't seeing any more ads.

Only other theories I can come up with would be Tor Browser interfering with uBO functioning optimally, or its version of FF not being new enough to work optimally with uBO.
This much more detailed story was posted on HN a few months back:
https://thehustle.co/the-popular-electronics-chain-that-scam...

Discussion: https://news.ycombinator.com/item?id=30829593
…and General Motors. Up until the ZF 8-speed, pretty much all the good automatic transmissions in BMWs were built by GM.
My company basically affords us the freedom to choose how much or how little we work. The ideal target we discuss is 3-day work weeks. Surprisingly, this still affords each of us around 70th percentile salary.

Grated, we're not a "product company" and instead work essentially as hired IT mercenaries, i.e. contract work, but it's a pretty sweet gig.

The job kind of found me. I posted my CV to some online forums (include here) and mailing lists, and a few random small companies contacted me over the course of about a year.

We actually keep our ears to the ground for interesting individuals, so if you're interested, feel free to shoot me an email: local-part: wilson, domain: rainlab.co.jp. We're fully remote, so timezone concerns aside, physical location is mostly irrelevant.
It means that it is a type of crime for which proceedings can take place without a jury.
In general, I don't find any noticeable performance issues using ubo on Chrome, but again I'm the "install it and forget it" type.

I do encountered a weird specific performance bug that is when cosmetic filtering is enabled, some heavy sites become very lagging, even affecting typing [1][2]. It also happens with other ad blockers. Unfortunately the author was unable to reproduce it.

[1] https://github.com/uBlockOrigin/uBlock-issues/issues/1687

[2] https://bugs.chromium.org/p/chromium/issues/detail?id=129245...
Just because statute says something is wrong doesn’t make the act criminal automatically.

For anything to be criminal there either has to be intent or the crime should be strict liability tort where intent does not matter.

It is arguable whether copyright infringement is strict liability tort in practice or not - there are arguments on both sides, so context of the particular case or similar cases that can set precedence matters .

So I wouldn’t be quick to just to say even say illegal let alone criminal.
Newsflash, game matchmaking 100s of players in a single game across an entire country ensuring they have latest patches to minimise hackers and cheats is slower to load than a wired LAN with known peers and zero risk of bad actors. but hey, nostalgia...
No license is inherently "All Rights Reserved", so you're correct.
parent-child in lucene is a hack. It only works when the children immediately follow the parent, and that never happens when it's in a different file because you updated the child. It's a minor miracle you didn't notice the error with numeric pagination.
I got a new phone recently, a Samsung S22. I wasn't worried about the lack of headphone jack because my previous phone came with a USB-C to 3.5mm adapter.

I plugged in my headphones through the adapter and my new phone told me it wasn't compatible with that adapter.

Smartphones are a mess right now, they're used as platforms to get consumers to buy into other products and services. You don't need a headphone jack because you can buy wireless earbuds, and you don't need an SD card slot because you can back up your photos to the cloud, and you don't need a radio because you can subscribe to a streaming music service, and you don't need a charging brick because you can buy a wireless charging mat. They're very aggressively pushing people towards all this new and expensive tech.
Are you running uBlock Origin? As when a site fails to load properly for me it's usually requires loading stuff I have blocked, unblocking it fixes the issue.
Perhaps we need to resume the old “tell friends and family to use firefox instead of $X”
A friend of mine has over 3,000 open in a vanilla Firefox at this very moment. Firefox restores the tabs on each restart without loading them and suspends inactive tabs automatically.
Maybe it’s a typo? They are missing a zero there ;)