skysight-inc/HackerNews huggingface dataset:
If absolutely no other variations of this part of the spike exist then the antibody could remain effective and our use of it wouldn't materially push the virus to mutate.

But, if any (survivable) variations do exist, their survival advantage would grow tremendously once this antibody saw widespread use in treatments, which would lead to the variations likely becoming dominant quite rapidly thereafter.

Still, there's no reason not to keep searching and studying. We may be able to make an effective treatment based on this.
Do not install these if you have hard water, they will clog up extremely fast - and the hotter your hot water is, the faster it will clog up.
Thanks!
Can’t help but wonder how conserved the relevant site actually is.

I wonder because targeting such a site seems to me like the premise of this kind of research: find “mission critical” highly conserved genes and then clinically target them.

And yet, scanning the paper’s abstract and introduction (the paper is linked in the posted article) I couldn’t find any mention of any highly conserved genome site. As a layperson I may have missed it, but still, if it’s a fundamental premise, I would have expected a conspicuous statement.

Instead, the paper reads to me like one concerned with a novel method for developing new antibodies with new methods of action. Not, as the article states, mechanisms of action against “mission critical” genes.

If I’m wrong, please let me know. But at the moment, I’m suspecting a misstep on the part of the scientific journalism here.
Maybe someone did it anyways even if it is prohibited; I don't know. I think the way to deal with this is that you can get another copy of the voting form if you want to take a picture of it, so that you won't tell if it is the real vote or not.
I’ve been whining about the constant agile-bashing for a while…I understand that implementing agile often leads to the MSDM model (many small death marches) but I never quite got the loathing agile gets from the tech community.

I think this gives me a glimpse. To me, agile is about adjusting your planning so you can get customer feedback and adjust your project accordingly. Without that, much of what I value from agile goes out the window.
And still doing interviews about geopolitics at 99 years old.
> Too many people discuss salary without discussing buying power.

In capitalism that is not important. If I have the negotiation capability to get a higher salary why should I accept a lower one just because I live cheaper?
All agree that world war brings far more destruction than benefit. It is therefore irrational. Why would it happen nonetheless? One clue can be the mental flexibility of the leadership. Unfortunately, there is little reason for optimism here. China’s extreme lockdowns seem to have more to do with CCP prestige than epidemiology. Western policies regarding inflation, budgets, internal cohesion also indicate lack of ability. Russia also made grave miscalculation in its invasion.
So, all major leadership is sorely lacking. This was a significant factor in the breakout of the First World War.
you can go on amazon and buy any one of a dozen trackers just like them. trackers that can't be detected like air-tags
(For people who read the comments first) the Osbourne Effect is when “a company pre-announces a future product that will obsolete the product line it’s selling today” (thereby killing current sales and revenue), and the Inner OE is when it’s the employees that are demotivated by a similar announcement (which devalues their skillset and obseletes their current project, possibly leading to mass resignations).
> Weekly scrub errors are definitely not normal

That depends on the scale of your cluster. The Backblaze drive report shows they lose 1.3% of their disks per year on average. Larger operations will have one or more people who just replace disks all day.
Maybe the time is right for anti-agile coaches to call all the companies that bought agile coaching over the past 15 years. I guess they'd be talking about why waterfall was best all along.

I think some of the root issue is the annoying micromanagement and lack of trust from non technical stakeholders. They need to chill out, but it's in their nature to be dicks somehow. They think if only they plug numbers into a spreadsheet correctly, huge savings will just pop out. But really they waste time and annoy the hell out of people. Maybe anti-agile is "fire all the nontechnical managers".

Agile as a system of prioritization isn't bad, but human factors mess it up a lot.
Alternative to Google Cloud IoT Core for Integrating Your MQTT Data with GCP
> The vast majority of foreigners leave within 2 years and very few settle long term, that is not a phenomena I've seen so starkly in other places I've lived in Asia.

I'm looking at the OECD stats here: https://stats.oecd.org/Index.aspx?DataSetCode=MIG

Looking at a before pandemic year (2018), that's 519 683 of migrants. Korea has 495 079, and that's basically on par with the UK and twice as much as France (provided France is twice as small in many metrics).

I don't give too much credit to the exact numbers, but Japan has a nonetheless a serious amount of foreigners, mostly from other Asian countries. They blend in much more than western foreigners so it's harder to tell from the look of it. To note there still is a culture shock and I had Chinese coworkers pretty heated up about many aspects, but they were pretty fast to understand how to make things work out.

I don't know your life, but if you traveled enough and got invited to work in a Japanese company, I'd assume you have a relatively high profile and the company inviting you wasn't some small scrappy business.

Big enough businesses are also traditionally slow and cumbersome, they have no incentive for speed and boldness, and if you touch any of the bigger companies making significant change just requires a ton of politics. I really believe that's basically the same everywhere. People might feel it's less static in Europe or USA because of more flashy colors, diversity and more buzz, but try looking at any company of the same size as Panasonic and look at what they're actually doing, and it's usually "not much more" (Think about Ford splitting out a separate EV division from the mother structure because nothing would happen otherwise)

On the people who stay long term, I think it's extremely difficult to judge depending on your position. In particular if you joined "expats" groups and made friends there, the probability a bunch of them leave after a while is usually higher.

I only sporadically met a few foreigners here and there, but 20 years later most of them have families and built a career. But they were not the type to spend their week-end in Roppongi bars either.
This is a pretty creative idea! My complex has had multiple small families of new kittens lately and I know at least one neighbor has had trouble finding the kittens since the other isn't always with them.
Talking is cheap and could be very misleading if your customer/user haven't put their skin into the game.
Amazon is copying TikTok now?
Improving Pipeline Performance: Process Memory Allocation and DAG
I think the intergenerational aspect is intertwined with the "centralized" aspect if zooko's triangle, because traditionally in DNS you have some central authority (ICANN, IETF, registrar) that is expected to "solve" that somehow by deciding who should be allowed to own certain domains.
That actually is a requirement with many DoD grants, in my experience. In general, such a clause would have to get additional approval from lawyers/grant admins at the university.
You know what I'd do if I had a million dollars budget?

I'll tell you what I'd do, man, two teams doing Feature Driven Development at the same time, man.
The medical community has a much more "it depends what you mean" attitude to gender (androgen insensitive XY vs. normal XX to name one of at least a dozen edge cases), and various nation's legal communities have recognised transitioning for a long time now. Culturally, attitudes have also varied a lot historically even prior to meaningful medical interventions.

I can barely remember any of Kindergarten Cop let alone trans issues, but a random film, no matter how entertaining, barely tells you about general culture, let alone what is "clearly understood by everyone" — it's not like the popularity of the MCU is evidence of "everyone" being pagans even though it features a race of gods as main characters.
Chapulines are not eaten raw, like most bugs they're fried or toasted in a pan or comal, but the study shows that parasites may survive that.

- https://en.wikipedia.org/wiki/Chapulines
Authoritarian regimes are designed top-down that limits the complexity of society and stifles innovation. Authoritarian regimes also fear an educated population further diminishing society value. A social democracy is in the opposite side of the spectrum, it is created bottom-up where citizens needs shape the government allowing for a richer more educated population.

Complex societies can and will produce better technology and creativity than simpler ones. So, authoritarian societies need an easy way to get money or they will be outcompeted by more open ones.

tldr;

Authoritarian -> simple society. Oil -> can be gathered by simple societies.

Social democracy -> complex society -> high-tech.
And the Russian counterpart of that book: https://en.m.wikipedia.org/wiki/Foundations_of_Geopolitics
When my boss needed a printer (to print out my contract for signing lol) a year and a half ago, he asked me what to get. The answer was, like always, a cheap b/w Brother -- since the LaserJet IIp is not in production any more.

It's just like the workhorse in the old pub cellar that chugged out ream after ream of paper through the dust and moisture for years without breaking down.

But with AirPrint too!
Isn’t it also the case that a lot of these contaminations in produce (like leafy greens) are caused by animal manure being used to fertilize the produce?

Without manure being used the risk is diminished by orders of magnitude.
I've mentioned them at my talk yesterday :)

https://youtu.be/WuWZqSSoLxY
I find that very shortsighted. Unless you're working on your own pet project, programming is like 20% of the job. The other 80% are designing, communicating, and collaborating.

You will not ship complex business software by just "Programming, motherfucker". You will build the wrong thing if you talk to the customer for one hour and then go off on a mad programming frenzy for the next 6 months. You need constant iteration and feedback (agile), or completely up front agreed-upon specs (waterfall), to not build the wrong thing. Both of these are absolutely not programming.

Next to that:

> "We are tired of being told we're socialy awkward idiots who need to be manipulated to work in a Forced Pair Programming chain gang without any time to be creative because none of the 10 managers on the project can do... Programming, Motherfucker."

This seems very stereotyping. Does anyone actually experience this? In this job market? The companies I've worked at are generally very happy to have a software engineering professional in the team, and are trusting of my word/estimations.

If someone would call me a "socially awkward idiot" at work, I'd have no problem finding another workplace that does respect me.
Even with all the inconsistency, we're better off than we were before SMART.

Although you could go by manufacturer reputation to some degree, back in the day. A few days ago I fired up an IBM 2.1 GB IDE drive that was manufactured in December '98, according to its label. It's been sitting in a drawer for about 15 years. Still working well, as far as I can tell.
So this is basically a "your tax is whatever I deem it to be"?
Some of foremost vaccine companies and medical experts in the world all but promised the COVID vaccines would give immunity to the disease and prevent it being transmitted.

So they really have far less of a grasp of vaccine effects in even that a very narrow situation than you would think. So I don't think you can just put this to bed with a few sentences starting with "it shouldn't happen"!
Seems like they finished the main storyline and are doing the side quests now
Note that you are demanding something impossible: you are demanding a "physical" explanation, but what you seem mean by "physical" is "something that I can intuitively understand with my preconceived notions". But nature doesn't care whether the reality fits your intuition or not!

The wave-function – a model that fits the data – is defined mathematically, and by Occam's razor, anything "fluff" added to it that makes it "easier to grok", makes it _further_ away from an actual explanation of reality.
Actually patents themselves don't have arbitrary length. They are 20 years and then done[1]. That said, there are patents on refinements or add-ons that come later, and so sometimes the patent expires but it has been replaced by a new way that is even better.

There is a scheme in the pharmacy market for shifting patents to prevent generics from being produced, that scheme would be outlawed if we had the right mix of legislators in Congress (basically fewer people who are dependent on these pharmaceutical companies for campaign funds and PAC support). But the original patents do expire, the trick is convince folks that they don't do what they do as well as the new thing does what it does.See here[2] if you want the boring details.

[1] I've got a bit over a dozen patents that arose out of work I've done for others and ended up becoming very familiar with them, even get the occasional expert witness work when trolls need to be disabused.

[2] https://www.upcounsel.com/patents-in-pharmaceuticals
It is possible that we might be able to back it into an evolutionary corner, but we don't really know enough to know which "directions" lead to dead-ends and which ones lead closer to a leap into a novel and more virulent pathogen.
I was very surprised about the "talk to your customers" part
vision direct co uk
Horrible mis-citation.
The scientific evidence presented is that the benefits far outweigh the risks.
Probably because there's no veggie as tasty as meat with a sprinkle of salt.
This actually seems like a viable solution. Thank you so much; I am going to pursue this. And gosh, wish I was in Michigan!
That might be true that higher density is more efficient, but efficiency isn't a sufficient metric for living overall. Putting everyone in camps would be more efficient too.

But do you really pay for suburbs? As I said, the cost intensive positions scale with the number of people. Schools, utilities, ...
Seems to rest on the assumption that customers want to. But in my experience, quite often the unspoken goals include not only "cheap" and "finished yesterday", but also "without bothering me outside of a fancy kickoff and that penultimate mission accomplished meeting where I bikeshed off through all the shades of blue"

That desire can still only be served by its opposite, talking to the customer, but it's a scarce resource, not just something you don't use enough of. Similar to how "finished yesterday" can only be solved by more time, but that can't be time measured in decades.
People eat them, not out of desperation, now and in history.

https://en.m.wikipedia.org/wiki/Entomophagy_in_humans

I'm going to say you probably haven't traveled much to be drawing such conclusions. Eating bugs is a big tourist shtick in Mexico for example. And you can go to markets with heaps of them on display.
We must end private software, and here's how
I've been lucky in that I haven't had to argue with agile consultants claiming their 90s project management techniques are agile. I feel fairly confident I'd raise holy hell until either they fuck off or admit that our organisation is no longer agile. You want to work like it's the roaring 90s again? No worries! Just don't lie to me to get me in the door. In this job market we have options.
Why, for example over say grass fed, organic steak?
Only little backyard operations use animal manure. No large food chain will carry greens grown in animal manure.
Call it what it is, a bribe to make people complacent.
This is ironic, because the Neural Prophet paper wasn’t reviewed either and didn’t benchmark it on anything other than Prophet.
There’s TamithaSkov space weather report on YouTube:

https://youtu.be/TCypTeodMYo

And there’s Lancaster University’s Aurora Watch, I’ve been brushing off the alerts since there’s so many low level ones. I’ll need to up the threshold.

https://aurorawatch.lancs.ac.uk/

But yeah, I might get to see what my degree project was about.

[Hopefully without getting Carringtoned, assuming this storm goes to about 5 - 10% of the magnetic field of the estimated Carrington Event and if such a comparison is linear]
My Brother experience on the Mac half a year ago was "install printer > pick out in list of visible printers > wait 2 seconds > it works"

On the phone it was just discovered by AirPrint and Just Worked™
Sure has to embarrass economists of the last 500 years. Silly adam smith, you just had to pass a law banning inflation duhhh
> Traditions don't necessarily contain good wisdom.

What is the bad wisdom here, that eating insects, rats, various other disease harbouring vertebrates is actually misplaced medieval health & safety?
Yes, since at least 1977!

Oubliette, a PLATO graphical (well lines :)) multiplayer RPG had a secondary market where people would in-game items for real-world cash.
I miss my 1993 OKI OL-400ex, such an elegant printer for its day. Like current Brothers.
If you have issues like that, definitely look into virtualenvs and requirements.txt. It's meant to isolate python environments from breaking like that.
Note this same argument is used against EVs. Saying the batteries should be used for hybrids instead.

In both cases, the fundamental mistake is to think of these as costs, when they are investments with rapid paybacks and so the obvious answer (and the reality) is massive expansion of battery manufacturing capacity.
If their research is of something that is attractive to investors, no doubt they will. Grants are often used to fund research that does not attract investment for whatever reason.
> a lifetime perpetual non-exclusive right to use and re-license said patent on what ever terms they deem acceptable.

Probably the biggest immediate positive impact would be automatically securing the rights to produce and distribute the patented good in developing nations. BigCo isn’t making much money there anyway.
The problem starts with the time between patent award and regulatory approval limiting the commercial exclusivity. This has driven big pharma to patent manufacturing processes instead of the compounds. If I understand it correctly from memory the Ritalin availability crisis was a example of process patent reengineering.

Edit: was not is.
I started playing bluegrass mandolin some years ago. I never really thought I could sing, but after starting to get into the local jam scene, I saw what a big part singing played and wanted to give it a shot. I took some classes and some workshops, and eventually started to get comfortable with both lead and harmony singing (I'm not good by any means, but competent enough for the jam scene).

If you listen to some of the classic bluegrass recordings, there's an incredible amount of nuance and control in the vocals, and trying to sing along and learn those subtleties is challenging and rewarding. And because there's a strong tradition of harmony in this music, the sustained vowel sounds Eno talks about are everywhere.

While the group singing Eno talks about is generally frowned upon in bluegrass, nailing a close harmony stack with one to three other people (depending on the parts) is a fantastic feeling. Building relationships around that, where you're looking forward to the next festival or music camp because you'll get to sing with someone again, is even better.

I got into this music for playing my instrument with others, but while I still enjoy that, I appreciate the singing a lot more now.
Bitbucket lost me when they dropped Mercurial support. If I've got to move to Git, anyway, why should I stick with them?
Those are business expenses.

> Avoid paying cap gains taxes on sale using 1031 exchanges

This is deferring the tax, not avoiding it.
> The landlord magically pulls a home out of thin air and some group of people maintain for them for free?

The building-lord should receive some return for their investment, as they have created value and added to it through maintenance.

The land-lord receives return for doing no work, no addition of value, and only through extracting the excess economic rent from their tenants.

Unfortunately, conversations around property investment and land taxes and so on tend to derail because the land-lord and building-lord are often the same person. The response to "the landlord is a leech on society" is "no, he built a house and maintains it!", but in reality it is "the land-lord is a leech on society, the building-lord is a contributor to society".
Let's start by using google docs
Eating pigs are much more likely to transfer parasites/diseases if prepared improperly. So in this case traditions do contain good wisdom.
Interesting to imagine feeding some of these room descriptions into DALL·E 2 and getting little room illustrations to go a long with it.
And Mac fans complain about Windows Updates being annoying? Sounds like pot kettle thing.
If you're just turning to flatpak, why are you even using guix in the first place?
No one ever needed a `leftpad` for strings.
$2/kWh is insane though. My power rate is $0.12/kWh.

$2/kWh is still 6x California’s most expensive power.
I'm also running ceph (using the rook kubernetes operator) in my homelab. Been running this setup for 9 months now with 2 cheap HP elitedesk workstations i picked up on ebay and 2 8TB HDDs in each.

Since this setup has run incredible smooth so far, I plan on using SolidRun's HoneyComb LX2 as a ceph node with bigger disks and nvme write cache in the future. I looked at the raspberry pi 4, but was not too impressed by the single PCIe 3.0 lane, since I also plan on using NVME disks as ceph's metadata storage device to speed up the hard disk with the normal data behind it and the ceph recommendation to use 10GbE NICs.

The HoneyComb LX2 has 4 built in 10GbE ports, 16 A72 cores, actual DDR4 RAM slots, a 4 lane PCIe 3.0 m.2 slot and an open-ended (so you can put in a full x16 device) PCIe 3.0 slot with 8 lanes for a max of 8Gbyte/s bandwidth.

Since it's an arm box it's incredible energy efficient which is important since energy prices are increasing in my country. Also its the only affordable performant arm device at 800USD.
In Firefox Android I pin the most used sites in the home page that opens when I touch the URL bar (and hides when I touch outside it) or the tabs button. I use my phone to routinely check those sites so I don't bookmark them on desktop. When I want to access them there I click the URL bar and type the first letter of the URL, n for this site. The browser remembers the full URL.

On Firefox desktop I also enable the bookmarks toolbar. I put there the links to the documentation of languages and frameworks I use most. I also got hundreds of bookmarks collected since forever but I ended up not using them anymore. I park pages in tabs. One browser window per customer (different virtual desktops) and a couple of them for me.
Here's a fairly recent article about the topic:

https://www.mdr.de/geschichte/ddr/politik-gesellschaft/entna...

While East Germany was indeed more serious about the de-nazification process than the West, in reality it wasn't as strict as the propaganda would want to make the world believe.

It's also fairly well known by now that the National People's Army (or rather its shadowy predecessor 'Kasernierte Volkspolizei') was also built up with the help of experienced WW2 officers while turning a blind eye on their political past. Eventually the NVA dismissed at least the highest-ranking nazis (during the mid to late 50's), but it's naive to believe that East Germany didn't have its share of tolerated 'old nazi bureaucrats'.