skysight-inc/HackerNews huggingface dataset:
And BPF, both of which are now known to have similar problems.

It's not like the companies developing these chemicals don't know that they're likely to have the same activity. It's just pharmacology. Similar structures tend to have similar activity.

I definitely second GPs suggestion of having the burden of proof reversed like that. It would greatly reduce the work required by researchers, too.

Interestingly, BPA was actually known to have estrogenergic properties in the 30s shortly after it was first isolated, and was first researched as a potential estrogen replacement. With the right regulation this could have been caught close to a century ago...
Cost-plus with a low cap and a “call me” for anybody who exceeds.
> I can always go outside to my grill.

That's a privilege a lot of people in cities don't have. I would love to have a gas cook top, but my building is electric only.

Edit: I'm also in the "advanced home cook" category, not a pro.
Good resources and tutorials about socket programming for IoT?
From 30-47 I have only found it easier to learn new skills. I’m 47 now and even in the last 10 years, I learned a lot. Like, how to build a full stack web app which I’ve used with our customers for a few years, to deliver millions per year in sales. I became an expert on at least a dozen programming tech acronyms to get that done. Also, I learned 2D/3D mechanical CAD design, I learned circuit design and PCB layout (fusion 360/solid works/eagle, etc), and I became fairly fluent in Mandarin including some literacy with hundreds of characters. I was naturally interested in those areas because it helped my business and directly improved my life to learn them, but I still had to force myself to continue and I think everyone does at some point. Of course, this is all anecdotal, but I don’t expect age related decline should be happening for most people at age 30 unless there’s some underlying physical health issues.
Haven't you read what I wrote? The 2001 decision was made to run the plants for 25 years. That was the decisions the Greens took part in. Every other decision was taken by governments without Greeen participation. You should carefully distinguish between those.

And what exactly are the effects on the European power grid you are talking about, especially any negative one? (Feel free to also list the beneficial ones)
The organized labor movement has a new ally: venture capitalists
What did you think compared to Grubhub now that they have the year free integration for Amazon Prime customers (which I guess is like 1/3 of American households)? I don't use the meal delivery often enough to have a representative sample, I've gone to order a few times from them and they all just seem insanely priced
If you own the building and live in one of the units the, in my opinion, most ethical course of action that still benefitted you would be to sell the remaining units to the current tenants or even better, if they've been living there long enough, treat their total rent paid as payment for the unit
Try Crossing Hand, Right hand on Q and Left hand on P.

It will help a little bit, not much.
I think if you find companies who do run integration tests 100 times per day, paying 2-3k per month to save around 500 hours per month does make sense.

You really have to work out your ideal customer, though. And find a way to scale it down - you can potentially use the capacity of more VMs spread across many smaller companies.

Maybe your business model is having a few clients pay you a couple grand a month, maybe it is having a couple hundred paying you 20-50 or so a month.

You do seem to have solved a problem, which is a great first step.
I believe dynamically typed languages are easier to use than old-style statically typed langages (Java, C, etc).

More modern statically typed languages can be quite easy to use (I am thinking of Scala) but none provides an ecosystem as rich as python's.

Plus, recent static languages (Scala, Rust, Haskell or even Elm) are more oriented toward "Software Engineers" or CS academics. Python appeals to a lot of "programmers" who's main job is actually data science, mechanical engineering, biologist...
Just to use your example, you would have a VERY hard time convincing me to spend $3,000 a month to speed up testing time. Running tests isn't exactly dead time. It gives engineers a break, they can think about other things while running them, get coffee, etc. There is DEFINITELY value there, but not $3k a month worth.

That said, pricing correctly is hard and requires a lot of experimentation. Growth and adoption might be more important at this stage.
taking iron supplements for a male is dangerous, my doctor told me years ago, for whatever that is worth
Agreed, when I (rarely) order from these services now I just usually assume it'll be 2x the time they state for me to actually get the order.
> they are hard to sear in other cookware

To sear steak in any pan (not Teflon):

Pat steak dry with paper towel. Brush with thin layer of high-heat oil. Season with coarse salt & fresh cracked pepper. Heat any pan (except Teflon) until Leidenfrost effect occurs. Put steak on pan, wait about 1 minute per 3 oz. Afterward, gently nudge steak with tongs; if it moves freely it's ready to flip, if not leave it on longer. Higher heat will result in more intense charring/crust, but will accelerate the process (will not have a significant effect on cooking of inner meat). After you flip, either reduce the heat halfway through cooking (won't work with cast iron) or plan to remove meat about 3/4 way through cook time. Remove to cutting board and rest 10 minutes [per lb]. Serve.

A dry surface + oil + very hot pan + wait until there's a crust is the secret to never getting the steak stuck. The oil ensures uniform heating and good heat transfer which will result in a more uniform crust and less sticking. You can go without oil but it can still stick if the steak wasn't dry enough or your pan wasn't hot enough or the surface is scratched. You could use butter but it'll burn.
Meta is not a hardware company. They make software for iOS, macOS, Safari (Apple), Android, Chrome (Google) and Windows (Microsoft).

I bet you also didn't know that Apple uses Samsung parts in their devices, or that Ukraine is transporting natural gas for Russia and get paid for it. It's a whole new world out there when you are not blindly zealous for no reason.
> Terrorists doesn't target nuclear powerplants since bombing one doesn't do much

On the contrary. Even if there is no radiation leak it can cause a panic, which is exactly what terrorist want

More importantly, nuclear is the most CENTRALIZED power generation. Destroying transformers or power lines around a plant is easy and leaves millions without electricity.

Unlike distributed power generation, like solar and wind.
My experience with flaky tests is that they seem to leave some state lying around, or are impacted by some randomness that wasn't accounted for in the test writing (lists in different order, DB state etc).

So I actually do think this would benefit that, as these tests are run "independantly", however that's just going to hide the problem of your bad/flaky tests, and you'll never solve the underlying problem.
You may just be closed off to the idea due to personality (not chatty) or due to lack of need (never needed to call and schedule a ride), but pre Uber (and maybe even today, don’t know) it was definitely common
Aluminum, even anodized, will definitely stick to food. Most anodized pots are treated with a teflon nonstick interior though and its color is very similar to the grey color of the anodization.

You do have to be careful about scratching anodized stuff too. The anodization will scratch and flake off if hit with hard material like steel. But again it's usually not anodized material directly in contact with the cooking surface since they put nonstick there.
Most people still don't question anything and blindly accept whatever the authority figure on TV tells them.
Given that these compounds are mass produced and spread all over the globe at an industrial scale, I think the plausibility of a problem should be sufficient for holding back. Especially when the compound is known to be non-degradable. Then we know, if there is a problem, we're gonna be stuck with it for a long time. Even more reason for extreme caution.
This is a great point, I was wondering why this seemed to work well for airlines and not Uber. And for airlines, I mean it's not even 24hrs sometimes, it's literally at the gate when there is 0 downside for them (other than the cost of a slightly more expensive meal and maybe some cheap champagne?)
>Cooling towers (evaporative chilling) use far less water than cooling directly with river water and returning hot water to the river.

Still uses a shitload. A coalition of states around me had the power generation companies install a reservoir so that in summer and drought they could keep the lower Delaware River navigable since so much was evaporated off in the cooling towers: https://en.wikipedia.org/wiki/Merrill_Creek_Reservoir
Twilio: Customers affected by data breach, no passwords stolen
What is the difference between this and creating a GUI the good old fashioned way and having a textfield subclass that knows how to two-way bind its value to a remote value?

In other words, if we ignore syntax, what is the fundamentally new capability?
> It was on, in front of my eyes, while I worked, ate and lived.

Either you're working or you're watching a movie. I know people who claim they do both at the same time, but I don't think they're actually doing either.
Citation? I tried googling and couldn't find anything to confirm that.

When I searched on half-life, the results that came up mostly seemed to discuss the half-life in the body, not the half-life in an environmental sink such as the ocean.
The thing is, Russia is trying to blame a possible blow up on the Ukrainians. That is their motivation to set it off instead of sprinkling nuclear waste or using nuclear war heads. Never mind all the damage they created around Chernobyl, though mostly contaminating their own troups by camping and digging in the highly contaminated forests around the former power plant. They also destroyed a lot of scientific labs which were controlling the power plant.

By the way: Medvedjev made some pretty specific threads against German power plants.
With food the question is less about the individual stocks of produce and more about the land occupied to generate it and who owns it, which in a distressing amount of cases is single large landowners
Why's (poignant) Guide to Ruby (and pretty much anything else by _why)

Let's Talk Lisp, by Laurent Siklóssy

Robots On Your Doorstep, by Nels Winkless and Iben Browning
Of course not.

https://www.latimes.com/projects/la-coast-ddt-dumping-ground...
Probably two reasons. You only have "two months away from the launch", so no time to re-architecture the existing working save mechanism. Why change it when you have an infinite amount of other works to be done? It's just a straightforward prioritization problem.

Also, it's fairly tricky to make the deterministic replay works. SC definitely do that for network play, but the risk is arguably higher for saving. StarCraft there were lots of synchronization issues even at very last minutes of its beta due to unexpected non-determinism which is probably because the game engine was not designed with that in mind. IIRC, the game would simply shutdown the session in a such case. But if it's from the save file, you don't have a way to detect that so the save file is going to be in a corrupted state with no hope of recovering. In the case of WC3, the engine has been written with lessons learned in the hard way so it should be capable of handling this problem more elegantly.
> Which, as bad as it is in general, shouldn't be that much of a problem since it is not in direct contact with water flow, being used to seal the joints.

have you ever taken apart half of those joints?

people love going overboard with the tape, when the threads are overloaded guess where the excess gets squished?
>makes you rethink how large highly functional cities can be.

And how exteremely safe
It sure does. The way Cypress works is that it injects their entire driver (test API) to the browser and then loads the tests themselves, also in the browser. It is a finicky process because they need to rewrite all JS and HTML (https://github.com/cypress-io/cypress/tree/develop/packages/...). It is slow because they have to proxy everything through HTTP 1.1 proxy (https://github.com/cypress-io/cypress/tree/develop/packages/...).

The thing that I built takes a different approach. It parses Cypress tests, interprets the commands that Cypress wants to run, and then uses Chrome DevTool protocol (CDP) to evaluate commands such as navigation, click, etc. If you are familiar with the JavaScript ecosystem, my tool effectively transforms tests to Playwright compatible tests and then uses custom orchestration logic to run them.
I think your pricing math is a tad off. I don't think it's harmful to use that for marketing, like you're saving engineering hours, but when you use it for pricing it falls apart. The reason is that you're selling to engineers, and we all know as CI is running, we aren't blocked. So, it isn't a 1:1 minute saved, although, I wouldn't conflate that with zero saved. In my experience a 1-5 minute test run isn't much different, but 3mins vs 30mins is a huge difference. I wouldn't force an engineering team to chisel 6mins to 2mins for example. I would roadmap how to reduce 30mins to less than 10mins. That being said, I think your equation needs more nuance to sell to an engineering manager or leader.
The early Internet, I don't know, I wasn't there.

The early web certainly wasn't full of scams. It was mostly made of stuff like the strawberry pop-tart experiments, recently resurfaced on HN: https://www.pmichaud.com/toast/ . That was at the higher end of quality, and there was plenty of commercial stuff (think company websites, not eBay yet), but it all had that same spirit, which is so rare today. (HN has a bit of that spirit, which is worth putting up with some crap to get even a small dose of in these troubled days.)

There was a major discovery problem though, which led to things like webrings and the birth of search engines and spam. Maybe not in that order.
Agh so good but so annoying :)
Why not be more ambitious and asking about quasi (Alcubierre) warp drives permitted by innovation in meta-materials?

https://www.technologyreview.com/2010/09/29/90189/how-to-bui...
Cutting food to the right shape to cook right and look nice really scratches all my engineer/programmer/chemist itches and when I get irritated because someone else in my household doesn't cut the vegetables "right" I have to take a breath and remind myself that this is MY problem not theirs.

This article gave me fun names for what I already knew and loved.
Its usually advised to carry both, so you have options. And to train with both.

Pepper spray doesn't always work, nor is it always the appropriate tool for the job.

And if you are carrying a firearm, carrying an IFAK is highly recommended.

For anyone and everyone, taking a "stop the bleed" class is highly recommended.
Entrepreneur in the RE industry from Europe (Luxembourg) here.

My gut feeling is "yes", and we hear more and more about Real Estate funds going to the residential market (they were dealing mostly with office and retail surfaces here before). It is kind of scary because it will accelerate a phenomenon. Commoditization will lead to the same thing, more money trying to buy a limited supply leading to a booming price.

However, recognizing that commoditization is a catalyst should not hide the fact that it is not the root of the problem. No one can promote demographic growth (globally or regionnaly), limit new dwellings and act as if booming prices are a surprise or the by product of greed. It is not, legal constraint has made construction a real pain but demand is growing.

To give a bit of nuance, on many markets rental yields has been collapsing has a consequences of this. Yes prices are climbing but rent are not. So yes, buying your home is a far away dream, but compared to the price of ownership rent have never been cheaper.
Apple chargers are weird. The mains connector is an IEC C7 / C8 connector, but there is an extra metal tab alongside that can provide ground but does not always.

My M1 MacBook Pro came with a UK plug, in which the slot in the top of the plug for the tab is entirely plastic. So, as it came out of the box it is not grounded.

I am using a mains extension lead that connects to the charger where the plug goes; its slot has metal connectors on either side that you can see if you look into the slot from the direction that the tab goes in. So, with the extension lead, the charger is grounded.

I noticed the mains buzz feeling in the case of my old MacBook when I used an ungrounded charger. I have only used my M1 with the grounded mains extension lead, and there is no tingle.
it is actually "Erg", not 69
I'm not sure about all languages but this actually caught me by surprise. When you do a 'mv' command (tested on macos) it does not retain file permissions by default. You actually need to pass a special flag in order to do so.

Objective C does retain perms by default using some common move techniques.
There are also sentences like:

> Unfortunately, in Japanese cooking, there are approximately 100 times more cutting techniques and names.
You are a sick person, crispisulcans, why would you bring misery to the world ? :D
> It's most certainly not, since for every kW of installed renewables another kW of gas capacity must be installed to compensate for intermittency.

Why? Built geographically decoupled production, look at past weather data and pick how many 9's up-time you want.

Then use storage and smart consumers to lower the requirements.

For national emergencies keep a fossil reserve or whatever, with that kind of usage power 2 gas should not even matter.
apex.sh is a nice example. it's not for everyone, but it's the best fit for those who need it.

maybe give them knobs on the amount of maximum concurrent tasks?
I don't think it does.

The default layout makes it easy to get around without learning keyboard shortcuts because it shows you what the options are per mode.

It would be pretty easy to create a plug-in that let you run different actions by name with fuzzy matching.
One thing I've recently discovered with my cast iron pan (now 20 years old!) is cooking pan pizza at home with it. I follow the America's Test Kitchen recipe here and it comes out unbelievably good, just like Pizza Hut from the 80s: https://www.youtube.com/watch?v=-srfPL5CWZs

It's super trendy to obsess over getting the hottest pizza oven--something that gets up to 800 degrees, etc--so you can get super authentic restaurant pizza at home. That's great and a fun hobby for some folks I'm sure, but a cast iron pan with a long overnight fermentation of the dough is a game-changer for from scratch pizza for me.
Infinite AND intermittent.

Renewables don't work for base load yet.
This is how my partner and I negotiated this.

We’re opposite in a lot of things we prefer:
- They love traveling w/ crazy schedules, bouncing around timezones for a week or two at a time.
- Sleeping and waking late.
- Going out late partying with friends.
- Spin classes or yoga with club music blasting.
- When not doing the above, they stay home doing literally nothing but watching Netflix or reading in bed for days on end.

They are either fully on, or fully off. I find this exhausting and/or boring as hell, depending on what mode they’re in.

I prefer the opposite in a lot of ways:
- Staying local, maybe taking a day or weekend trip every few months, and international trip once a year.
- Waking and sleeping early
- Time alone every day
- Working on personal projects or hobbies
- Lifting weights or exercising while listening to stimulating lectures or books.
- Having hours-long meals with friends or family once or twice a week.

We’ve found that instead of trying to do things we don’t like to appease the other. We find things that overlap for us and make it a point to do them together whenever possible:
- Cooking some meals at home
- Walking our dog around the neighborhood
- Going on day or weekend trips once in a while.
- Meals w/ friends and family, when I peel off to go home after, when they go meet up with friends to burn the midnight oil.
And yet it's potentially very easy to prove something is unsafe, or likely to have unforeseen effects. In vitro bioassays, animal testing. Lots of the chemicals causing problems today could have fairly easily been screened out this way. Just because epistemologically it's impossible to ever know for sure something is safe, that's not a justification for going ahead with almost no testing at all.
No, this seems to be false. France is importing electricity for years from Germany - at least since 2015.

I'm not sure why you're saying that France only has an issue because of Germany? Where do you get that from? Even a french power grid operator is saying that they import more power from Germany, than they're exporting (https://www.rte-france.com/en/eco2mix/cross-border-electrici...).

But you're not even responding to my main concern - that nuclear power is so expensive, that it is never competitive. Only when subsidized. And that is for power plants that are already built - not new ones (which seem to be an even greater money pit). Why is the biggest nuclear power company unable to make money in France and needs to be rescued by the government?

I'd say if it makes sense and helps us in our current situation, just subsidize the heck out of it, even if it costs us as a country lots of money. But it absolutely doesn't seem environmentally friendly, not even regarding CO2. And it doesn't seem to be feasible to quickly build nuclear power.

But yes, Germany fucked up regarding its dependency on gas (from one source and then it's even from a country like Russia).
“Oh it’ll probably be fine” is just not good enough any more. We’ve destroyed and irreparably harmed huge swaths of nature in a vanishingly short period of time due to this attitude. It has failed again, and again, and again. If we keep this up, we really will destroy ourselves and the habitability of the planet. The consequences are just so dire now that the notion that we should just roll the dice is frankly absurd. If we don’t know it’s safe, assume it’s not. Perfect? No. Better than the alternative? Yes.
Autodesk, already renowned as one of the worst IT companies under the sun finds new and innovative ways to fuck their customers sideways, news at 10.
Listen to context about this (tl;dr, the growing number of deployment targets for modern apps/libs/frameworks) from the recent Syntax podcast.

See the 27:01 mark, https://syntax.fm/show/496/supper-club-headless-ecommerce-wi....
Are you under the impression that Ecuadorians never discard brown bananas?
What is it, exactly, that you think chemical engineers do? Blaming them is like blaming the plumbers' union for Flint Michigan's drinking water.