skysight-inc/HackerNews huggingface dataset:
It’s not necessarily a pre-requisite: many of the more “exciting” drug platforms like Antibodies (which comprise like 90% of approvals nowadays anyways) in principle DONT NEED any structure info a priori. You don’t need to know a proteins structure to generate antibodies, just the protein itself to either inject into an animal or pass through a phage display column. Now typically drug companies will of course only work with proteins whose structure is known. Please note that the top drug companies have some of the best crystallography departments and they will most definitely get the structures done experimentally (if it’s possible). AlphaFold will likely help with that for sure. But it’s just one of those things that’s just a nice to have. If a protein is truly important and you cannot tell it’s structure you can still go ahead and make an antibody drug against it and Even characterize it using mutagenesis analyses.
Why following the same steps in the wrong direction?

When future search engines begin receiving feedback from users and ranking accordingly Google will become irrelevant.
> They claim that “according to their ongoing reviews and subjective numbers” less than 5% of accounts they qualify as an monetizeable user are “false or spam”.

Yes, it's just a short version for the sake of the discussion.

Let's just say this number is not 5%. It's 30% when evaluated by an independent third party.

Other comments claim that this number can be 90% 80% and it wouldn't matter. Twitter would be relieved of all responsibilities because they said it was "subjective".

This is where I disagree.

> You’d also have to show that Twitter knew that their process and judgement were flawed to the point of deliberately being deceptive.

This is where the discovery comes from. You'd imagine it is impossible, but it's not. It may be still hard, sure, but not impossible.

Twitter would be requested to open up all emails/docs for discovery to both sides of lawyers.

Twitter has 8000 employees(?). You can bet there will be at least one person pointing out in the email/doc that "hey, our approach of evaluating numbers doesn't look right, and here's why....". Then, that person has been ignored.

Twitter would be requested to open up data for discovery for third parties to investigate.

Coming up with a number like this will inevitably have multiple valid approaches. An independent third party can easily pick a more conservative approach (because you are supposed to err on the side of less attractive when reporting earnings). Then, pairing this with Twitter execs ignoring that one concern from employee can result in a really bad situation for execs.

Apart from that, opening up emails like this would incriminate a lot of other unrelated stuffs like employees know about Russian bots that swayed the election results, employees know about fake news but not doing anything about it.
This answer would be the answer if it meant there was no demand for electric versions of these products, but there’s tons of demand. You can search “electric [insert product]” and see people clamouring for it and waitlists for the startups trying to break into the field with electric. The incumbents though, are asleep at the switch.
Or normal corded telephone handset.
Why use graphql at all if you are going to use it just like a traditional REST api? You don't get much of a benefit from the client selecting which fields it wants, the backend probably fetches the entire DB row anyway so why not just send the whole thing over?

The limitations of the query language make code size explode the moment you step outside simple toy examples. It doesn't have any concept of a JOIN, or of the actual relationships between your types (graphql has no concept that me == me.parent.child). You end up writing
data loaders for every type so that loops in your schema can be resolved efficiently.

Managing permissions is so much more of a pain compared to REST because exactly what data is returned is so much more dynamic. If you have some confidential data nested 10 layers deep in the query, you get two choices. Either fail the entire query with a NotAllowed based on one deeply nested field that the client maybe does not even care about, or you have to make your schema super loose and make every single field that's subject to permission management nullable. So much easier on a REST endpoint because the response is more constrained.
the (log) streams all run into the (data) lake
In my experience, "let's do something non-scalable and obviously wrong while we're exploring the problem space and replace it with something better before shipping" reduces to "let's do something non-scalable and ship to production" 100% of the time.
> "Valid"? As opposed to "invalid music"?

Yes, I think it's clear the author means things we collectively agree fall under the category of music. And the question of what is or is not music is surprisingly complex and disputed, analagous to the question of what is or is not art.

E.g. is John Cage's 4'33" [1] music? What about a Spotify track of silence for meditation? Is a purely percussive piece music, or merely rhythm? Is atonal music, well, even music at all? Classical musicians would pretty much all say yes, but a lot of non-musicians might disagree.

[1] https://en.wikipedia.org/wiki/4%E2%80%B233%E2%80%B3
See my response to a sibling comment. I don’t believe lack of demand is the explanation.
I still use this regularly. I literally used it yesterday. It’s a great solution to the problem of “how can I tell what is taking up all of the space on my drive”
"Applications to a sandy soil of the partially purified surface-active compounds improved soil water retention up to 314.3% compared to untreated soil. Similarly, after 36 h of incubation, the humidity uptake rate of treated sandy soil was up to 607.7% higher than untreated controls." ...
"Overall, results revealed that polyextremotolerant bioemulsifiers of bacteria from arid and desert soils represent potential sources to develop new natural soil-wetting agents for improving water retention in arid soils."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984429/
>We're headed towards a word where data gets put in a blender to decide what to try next. That entire pipeline can and will be automated. And in that world, human ingenuity and expertise may become far, far less relevant.

Let's hope we'll be dead by then...
Thanks for clarifying. I did think saying "Thanks" to the person who corrected me is a straightforward admission that I was wrong... if not - yes, I was wrong.

To the downvoters above: is a "thanks" to a correcting comment not enough on HN?

Also, was it rude to say hiding content "below the fold" is a design problem?

This is a very odd thread to me - like I was being chased down by pedants who are calling me pedantic.
not what i'm saying. the vast majority of people who work with spreadsheets have no interest in redefining it to align with other paradigms. spreadsheets work damn well as they are
And politics.
Right, but on the backend someone had to think ahead of time that somebody would want to JOIN between those two types, and remember to put the field in place, and implement the JOIN.
It is odd/amazing that the Ouachita mountains are included in the "Central Pangean Mountains" given how far west they are.

https://en.wikipedia.org/wiki/Ouachita_Mountains
It still looks good!
I appreciate the links. It looks like red light cameras are indeed much less effective (and maybe even counterproductive) in the rest of the US. As a pedestrian, I consider them a blessing in NYC.
Our monitoring says all the requests are 200 OK, why is the client down?
Very nice work, need more posts like this.
none. whats life without chaos and suffering?

kidding i just use lists. lots of it. on paper and online, whatever is accessible.
> A customer required me to use Skype for a meeting just the other day, It let me authenticate and verify an email account, but before I could even use it, it locked up and asked me for my phone number. This over reach is out of control.

I can't recommend Whereby enough.
Yes, it's tongue in cheek.
Internally Google started on Perforce and gradually replaced its backend. Their client (not available outside their org) is g4 rather than p4.

Some dedicated/stubborn devs also used to (maybe still do?) manage local history in a git-based tool with pushes on demand to a g4 changelist for review.
> in next sub-version, the commands can have completely different switches

That claim seems crazy and doesn't match my experience at all. Please name a widely used program that changed its switches completely in a sub-version.
I joke mostly. Coming from a REST based background it was really foreign and convoluted to me.

Until I understood the point, the organizational decoupling. Then it clicked why it's great.
Robert Lacy's biography "Ford" has a brief but entertaining discussion of the making of the mural. Edsel Ford kind-of knew what he was getting into, but he didn't really expect a Marxist polemic to the dignity of labour.

Henry Ford senior was a complex, hateful, racist, antisemitic reactionary, prepared to hire goons with machine guns to take on strikers but also capable of investing in illiterate and monoglot immigrant workers with housing above standard for the time, and wages designed to kill his Detroit competition.

Crazy like a fox and a bastard to his family. He cannot have been ignorant of Diego Garcia's world view and yet.. the mural remains. I have no doubt ford senior could have killed the project if he wanted to. Henry died in 1947.

Ford's conflicted relationship with Edsel who was into modernist art lies at the heart of it I think: Edsel wanted to show he was above the shenanigans of his father, he funded the work. Henry bought up old time tractors and Edison lab trash for his historical museum in Dearborne. He wasn't into funding socialist artists.

Unlike the one Diego Rivera did for Rockerfeller, with Lenin in it, which was covered up.
I agree, most of the criticisms seem to concern overall unimportant technical issues. I'm using Linux since 2008 for all of my work and I haven't had any problems during the last ten years or so. I have no complaints about X, it just works fine.

What is hard in my opinion is migrating to a new machine or changing major hard drives. There is still no good migration assistant and so many things can go wrong with a major change. But that's pretty much my only complaint.
"very quickly" is wishful thinking, nothing else. which is fine, by the way, just not real.
Another great devlog thread on TIGSOURCE is Leilani's Island by Craig Forrester, it's a treasure trove of 2D platformer development:

https://forums.tigsource.com/index.php?topic=46289.0
See also Tom Scott's "The 400,000,000-Year Link Between Scotland and Canada"

https://www.youtube.com/watch?v=GAKwRou6HUw
> "Valid"? As opposed to "invalid music"?

I think it's fair to say that sometimes people attempt to make music and aren't successful. That doesn't mean music that gets played on the radio that some person doesn't like isn't "real" music. I'm thinking more like a musician tries out a chord progression and decides it's not working musically so they never record it in the first place. Or if a cat walks across a piano the result probably isn't music. There will always be grey areas, but I think there are things that are almost universally regarded as music, and other things that are almost universally regarded as not-music. Some part of musical appreciation is subjective and culturally influenced, but some parts are innate and based on mathematical relationships and psychoacoustics that are the same for almost every human.

> I-V and IV-V seems to be the same with the point of reference moved to IV

I-V moves up by a 5th, whereas IV-V moves up by a major second. I would buy that I-V is the same as IV-I, but with a different point of reference.
Thanks a lot for pointing out the The Creature of Jekyll Island book!
As much as I appreciate the article trying to stem the tide of racism by pointing out the El Paso shooting, I don't think such arguments are fruitful.

Firstly, that shooting doesn't mean immigration is good for the US (or, let's be blunt, for whites in the US), just as the lack of such a shooting wouldn't mean immigration is bad.

Secondly, an opponent could simply point to (anecdotal) murders perpetrated by immigrants as a counter-argument (well, counter-ad-hominem, since the El Paso shooting isn't really an argument for or against immigration). And in fact many publications do just that - the Daily Mail, NY Post, and Fox News to a lesser extent.

In the end it boils down to who can shout the loudest, regardless of the underlying truth. This might not be the case if they used statistics, but they prefer emotionally-resonating anecdotes, which, in a country of 330 million, are meaningless - you can find anecdotes to fit any preconception.

So what I would suggest is using arguments where truth, not just volume, provides an advantage. Instead of merely calling replacement theory "false", substantiate that with demographic statistics, showing that nobody is being "replaced". Anything less is simply yelling "nu-uh" - completely unpersuasive, and much more ineffective than manipulating people with cherry-picked crimes.

Unfortunately journalists are notoriously allergic to statistics, so we have little hope of laying this "debate" to rest.
comment on the blog says they should not be. It's by Bob Costas but surprisingly missing a half hour preamble of fluff about the early life and struggle of that little hill before it became a mountain range.
It’s a bit like studying how to reduce your chance of lung cancer from smoking if you want to keep smoking. No mitigating factor will eliminate the risks from red meat, except not eating it. Also lifestyle or nutritional mitigation factors are difficult to study, and it’s never clear if they apply to a given person with a particular genotype and environment.
https://lv2plug.in/
As someone who works with Transformers and DL in general I decided to chime in:

>They can be aware of implicit correlations and constraints that are totally outside what may be recognised in the scientific understanding. Hence AlphaFold is quite capable of predicting a structure for which there is no previous direct "analogy".

Yes, while an expert of their field, I suspect author doesn't have full understanding of what neural networks or ML is capable of, in this case it's not necessary to have seen fully similar molecules but it is sufficient for AlphaFold to have encountered basic blocks of the vocabulary that are familiar. One can see how this argument would be silly if (hyperbolizing) someone said that just because we are located in a tiny part of observable universe the physics we know to work here wouldn't work in Alpha Centauri. To make this point simpler, this is no different than suggesting that a model will break if it encounters an out-of-vocabulary word, whereas in reality a simple tokenization technique would ensure that in majority of these edge cases, the unknown word would be broken down into subwords, which, in turn, would still be familiar to the model and statistics that model has learned would still give it a reasonable guess as to what the sum of the parts entail. There was a recent work (https://arxiv.org/abs/2207.05221, in LLM, not molecular prediction) where models could be shown to "know" (oh G-d how tiresome it is to make these disclaimers, but models are NOT sentient) fairly decently what they don't know. Thus, I wouldn't be surprised if AlphaFold could at least give a confidence score to its prediction of folded protein, helping scientists who use it as a TOOL (which it is, it's not a solution) to exercise caution.

>As long as the protein has to follow the laws of physics then AlphaFold as at least a basis to work from in successfully predicting the structure.

This is pure speculation. There is no guarantee AT ALL that AlphaFold follows laws of physics other than the way predictions are clipped to be reasonable distances between molecules or other "hacks" authors have added as "inductive" (actually symbolic) biases to the model.
I can't believe that either. At most I'd have written an angry blog post and never updated it.

Don't know what keeps him going. A desire to see FreeBSD fix those defaults? Desire for OpenBSD to be recognised as having better defaults for security than FreeBSD? What would that even look like?
Indeed, and Copyright etc. still applies, of course.

But in most jurisdictions, what you do with a DVD that you bought, in your own home, is totally up to you, so you can install the game even if the company that created it no longer exists. Heck, in most jurisdictions you can even legally disassemble the game and remove any form of online activation or similar, if the servers are no longer available
Less obsessed with money. Less vanity. Less self-indulgent. Less naval-gazing.

Everything isn't "me, me, me" with most of the Z's that I've observed.

They're more tolerant. Every disagreement doesn't boil down to "Stop liking things that I don't like." And they don't have as much of a persecution complex as the Millennials.

Gen Z and Gen X are very much alike. Just as Millennials and Boomers are pretty much the same people.
rigid means they are not jointed, i think, not that they necessarily dont vibrate...
"If you can't love yourself, how the hell you gonna love somebody else, can I get an Amen!?"
- Rupaul
Two news sites with great UX are both, oddly enough, radio sites:

* https://www.rnz.co.nz/news/world/472090/chinese-warplanes-bu...

* https://www.npr.org/2022/08/06/1114420271/ukraine-kherson-co...
The Artificial Intelligence Database
What’s not included is the confirmation that they are under attack.
I wonder how real the "not relieved by morphine is", or what that means exactly. Looked into this a while back and only found this source [1]:

> Intravenous access was obtained and 15 mg of morphine was given slowly. Over the next five minutes very little pain relief occurred.

> [...]

> A further 7.5 mg of morphine was given intravenously 15 minutes after the
first dose, but again this produced little relief. Over the ensuing 15 minutes a further 7.5 mg of morphine was injected intravenously, which eventually reduced the pain to a tolerable level.

[1] https://onlinelibrary.wiley.com/doi/abs/10.5694/j.1326-5377....
I would start off by making something with a RNG, a loop and a setPixel(x,y) in your favorite language. You'll be Picassoing it up in mere minutes.
Chip Morningstar interview: How the metaverse started with Habitat
Comparing artistic production to driving is a poor metaphor.

No doubt that AI-driven tools can be leveraged by artists to create interesting things, in the same way that visual artists have used tools like Photoshop.

But there is something much more profound happening with DALL-E, etc. As I mentioned above, these AI systems simultaneously depend on human artists to populate its training corpus, while making it much less likely that these artists will be able to make a living producing art.

Even if other artists working higher-up in the value chain benefit from these systems, you are likely to see fewer professional illustrators and visual artists because these systems exists.

Something will be lost. We can hope that what we gain in return will be of equal value.
To compete with Google you can’t just use their legacy tech (pagerank, mapreduce, etc.), you have to come with a better tech.
Hey, thanks a lot for pointing out this book!
Same here. I think I first found it on a shareware disc years and years ago, but still use it today on my Windows 10 machine
Your sentence lacks much substance other than an extreme leap of judgement based on a commonly used phrase. Seems like “fakery” to me.

Using a hospital or school as a base to launch attacks may not be a war crime, but …

“If there is any doubt, they cannot be attacked. Hospitals only lose their protection in certain circumstances - for example if a hospital is being used as a base from which to launch an attack, as a weapons depot, or to hide healthy soldiers/fighters. And there are certain conditions too.”

https://www.icrc.org/en/document/ihl-rules-of-war-FAQ-Geneva...
Thank you for the book suggestion!
Even then, though, Schoenberg was still following voice-leading principles usually. He'd just abandoned tonality and harmony.
It is called out separately from the Appalachians. Wikipedia cites this article, which is terse enough to not be convincing to my lay eyes.

https://archives.datapages.com/data/sepm_sp/SP22/Sedimentary...

This book chapter cites the above and has a picture explanation:

https://books.google.com/books?hl=en&lr=&id=DyF3BQAAQBAJ&oi=...
I think it would be interesting to simulate the audio of a fuel engine in EVs and be able to customize the output. Otherwise they sound a bit too boring.
Aren’t most mountains older than trees? Maybe even all of them?
The messaging isn't really that mixed. Folks mostly want the police to enforce and investigate more important matters than they do now (speeding vs overly tinted windows, for example, or home invasions vs sleeping in a park).

edit: removed snark.
If I explicitly typed a leading 0, I want it to stay unless I'm typing it into a numeric cell. In that case I'm doing something strange and wasting my time but what I want is obviously 1234.
For me conferences were never about learning but having some relaxing time with my teammates in a different country/city for a couple of days. The best tech talks out there are on YouTube.
I don't know why you're focused on single-engine airplanes. My twin-engine airplane would certainly annoy you twice as much if I flew it low and near your home, which seems to be the sole basis of your complaint.

You're in luck, the ghastly economics of private flight will continue to reduce the numbers of us indulgent and entitled pilots until we're just a bizarre niche, like people who own locomotives.
Is pleasure flight a euphemism for something?
Great news! I have the v1 and it's a really good iron that doesn't look bad at all along my two Wellers. The power and tips thermal mass is more than enough for serious solder joints where some very popular low cost soldering stations, mostly crappy Hakko clones, fail miserably.
This reads like deep depression.
https://man.netbsd.org/wpi.4

>wpi%d: fatal firmware error For some reason, the firmware crashed. The driver will reset the hardware. This should not happen.

They know.
I suspect the reason this article came up was because it was referenced by a comment on another recent one: https://news.ycombinator.com/item?id=32337934 (from https://news.ycombinator.com/item?id=32337520 ).
This looks pretty neat, I'm considering using something like egui in rust for creating VST plugins. something like https://github.com/DGriffin91/egui_baseview_test_vst2