skysight-inc/HackerNews huggingface dataset:
I don't think non-globular proteins are well represented by the predictions. All our predictions for proteins are based on proteins we were able to crystallize, so my guess is that even if many of them aren't globular proteins the predictions themselves are made from the foundations of structures we do have, which are predominantly globular proteins and it's presumed that the inference treats folding as if they were globular and crystallized (non-dynamic). X-ray crystallography and fitting to electron density maps itself is a bit of an art form.

For example for transmembrane proteins, there is a gross under-representation of structures derived from experimental evidence, so we would expect that whatever your algorithm is "solving" is going to have a much higher degree of error than globular proteins, and likely artifacts associated with learning from much more abundant globular proteins.

edit: As an example, "Sampling the conformational landscapes of transporters and receptors with AlphaFold2". AF2 was able to reproduce the alternative conformations of GPCRs, but only with non-default settings. With default settings there is clear evidence of overfitting.

> Overall, these results demonstrate that highly accurate models adopting both conformations of all eight protein targets could be predicted with AF2 by using MSAs that are far shallower than the default. However, because the optimal MSA depth and choice of templates varied for each protein, they also argue against a one-size-fits-all approach for conformational sampling.
We both know no one opts in to stuff. More importantly, when dealing with self-selection bias, you don't know if the data you're collecting is representative of the entire population of users, or just the volunteers. So if you don't have a large enough data sample, there are no benefits to anyone. (e.g. "Everything must be fine. No crashes." Little do they know, it immediately crashes when visiting any of the top-100 domains by requests, but the volunteers never visit any of them.)

I would take your claims more seriously, if you could speak to something concrete about deficiencies of what is collected, and how, and what steps were taken to anonymize the data, how it's retained. (Fun fact: You can! It's all documented.), and articulate something beyond, "I just don't wanna, and I think my minority opinion should be imposed on everyone."
This is false. The problem is that Google is trying to replace an open method of tracking users (third party cookies), with one which places them in the sole source of authority (FLoC, Topics, etc.).

If they did what every other browser has already done, and just blocked third party cookies entirely, because it's a security issue, they would not face a legal issue. In fact, they would be able to entirely defend the move behind "we're just doing what every other browser did first".

The choice to monopolize tracking instead of removing tracking is the issue at hand there.
Harsh but I so want to say "true".
If the transaction OP did through stripe was for a product(s) containing CBD/THC (EDIT: They sold a van. > We sold a cheap van in the company name. ) then I can understand why Stripe closed the account as it’s on their restricted businesses list (often not because stripe disagree with the product, but the providers stripe use disallow them and stripe have to do so otherwise risk losing access to the provider for everyone). And once the account is closed there won’t be any more transactions on the account to recoup the cost if transaction’s get reversed down the road.

But that doesn’t excuse Stripes lack of communication / canned replies. Even if you are parting ways with a customer it’s not wise to burn bridges, who knows maybe CBD/THC products won’t be shit listed later down the road and you would welcome the customer back. But leaving a nasty taste in the customers mouth will make them much more hesitant to return.
What’s wrong with using email or Intercom?
I fell asleep before take-off in Canada (YYZ) for the UK (LHR) a few months ago. I slept most of the way; it was only through conversation afterwards that I found out there was almost a 3h delay before we even started taxiing.

If you're saying you have awareness while sleeping of something that should happen, and you'll wake up if you don't detect it, I certainly don't share that.
Others have also made a similar observation, for India vs US. https://twitter.com/__apf__/status/1408429235165749248
Average annual turnover for 1-9 employee companies in the uk is ~£500k, £3k represents around 8% of their monthly turnover. There's no world where that is insignificant.
It's not losing 3k, it's delayed payment
Did you buy it from Amazon by any chance?
While unquestionably semis, etc. are of vital US concern. However, why should the companies be subsidized by the taxpayer? All of these companies are profitable. All are multi-national. All can sell every chip they make, etc. This smacks of Soviet style industrial policy or crony capitalism, if you prefer. And in the end, when the subsidies cease, they will again shop themselves to the highest bidder. Strikes me as extremely short sighted.
Been there. Switched to 24-hour time (8:30 PM = 2030).

Now I'm only annoyed by the number of devices, applications, and people that don't support 24-hour time. :)
Thanks! Yeah that is not in the page. Not sure how that is getting prepended. I’ll send to support!
> It's not a conspiracy ... poerful [sic] supranational organizations.

Come on. You can't claim that something isn't a conspiracy and then invoke world-government conspiracies in the same paragraph and expect to be taken seriously.
Creating "competing"* services does not solve the problem of how Europeans can continue to use U.S. services if and when they (we) prefer to do so based on technical merit.

I don't think it's a good idea to let the world (and the internet) fragment into ever smaller jurisdictions that can no longer find a way to trade with each other.

We need a legal agreement to sort this out or everyone will be worse off.

* They wouldn't actually have to compete at all if U.S services were banned.
Is dollar going to stop being world reserve currency with 15% inflation?
I'm genuinely sorry you had a bad time. People of every background feeling welcome and being able to contribute is what it is all about.

RMS being reinstated was simply not a smart move, I think it does great harm to FSF. For example, when FSFE reached out to me they explicitly mentioned distancing themselves from FSF due to Stallman.
I've seen this post on hackernews a few times now (as dang diligently pointed out).

However, typically they don't mention that more recent versions of Stow actually have specific functionality for dotfiles, which is support for the `dot-` prefix.

Check the man page for your version of stow. If the string "dot-" doesn't appear anywhere, you have an old version of stow.

Also interesting to me was the fact that the `make` manual has information on how `stow` is actually one of the recommended workflows in makefiles (in the context of setting a DESTDIR); but I've never seen anyone actually do that in practice.
What conclusion are you trying to draw from this subjective view?
Long time Instagram user. Deleted my Facebook account years ago.
The recent changes to Instagram totally suck. I hardly see any of my friends pictures anymore. Maybe one, or two, then a constant shit-stream of 'reels'.

I am done. No more Instagram for me. I am hoping someone will bootstrap a replacement that basically replicates Instagram from two years ago.
The other commenter answered it (that unity’s source costs money to get access to), but my comment wasn’t about whether it’s proprietary or not, but rather if the source is available/accessible. Unreal’s source code is on GitHub, but it’s still proprietary. You cannot redistribute it or anything like that.
Without taking away from your point, deep in the Reddit comments the OP states Stripe put a hold on the account after billing the sale of a literal company truck through Stripe and not via selling their normal store merchandise.

https://reddit.com/r/smallbusiness/comments/wa1zob/_/ihyq7tl...

As usual, there’s always an undisclosed fact that changes the narrative and explains the ban. Whether this should trigger Stripe’s scorched earth mechanisms is another matter.
If I ask "Why do birds fly south for the winter?", and an ornithologist just says "Well it's not what your friend said!" and walks away, that is not a reason why birds fly south for the winter. It doesn't help anyone understand the subject. But because the ornithologist is an authority figure, people take that as an explanation. People will then chatter among themselves and decide that whatever the group thinks must be true.

Besides the fact that he did not give a reason why GNOME/GNOME 3/Unity happened, he is also still a human being, and thus is subject to bias, deception, forgetfulness, mis-remembering, etc. That's why if you want a real discussion it's useful to have evidence, not just whatever hypothesis sounds good to an in-group.
To add to this:

Prompt: Write a hackernews comment about why artificial intelligence will never be profitable

Response: Artificial intelligence will never be profitable because the cost of developing and maintaining the hardware and software is too high. Also, the market for AI is still too small and the demand is not high enough to justify the costs.
It would raise the effective price of switching, making the bribe more expensive.
It's probably because the US is generally wider than tall but the NE US has many more states, so that leaves an otherwise empty space in the top-left.
Guilty
But is that, you know, true? The HN front page gives a stunning amount of credulity to unverified stories from random people on social media.
I rarely do. I have 3 monitors and usually just place one window per monitor.

When I do switch, it is easy, flip to hot corner, pick window, done.
You are right and when thinking about it I can see 2 problems which I hope in the future can have even more impact:

1. Using AI to determine the most efficient methods of doing mathematical expressions, transformations and computation algorithms - division, square root, maybe traveling salesman - these which take relatively high amount of CPU cycles to compute and are used everywhere. If inputs and outputs can be assigned to it, AI can eventually build a transformation which can be reproduced using a silicon.

2. Physics phenomena in general, not only organic protein, can be measured and with sufficient ability to quantize them to inputs and experimentally obtained outputs to train the network, we could in theory establish new formulas or constants and progress the understanding of the Universe.
Don't know what country you are from but guess your acquiring bank gets orders of magnitude less fraud than Stripe does so your bank can afford to take your calls.
It boils down to wildly skewed regulatory environment in the US.
> The Ents probably being the chief example.

The Ents were made by Yavanna, in the same way that Aulë made the Dwarves, according to my memories of the Silmarillion.

They awoke at the coming of others, and they were taught speech by the Elves.
If you're actually interested in changing your car color, you should could look at wrapping. It's still expensive (thousands last I checked, which was before any measurable inflation took hold), but cheaper than painting and obviously less permanent. I've heard it's better to wrap black/dark vehicles because if the measurement and cuts are a bit off it gets hidden away a lot better than something like red or blue. But could still be an option!

I had a dark gray car many years ago that I wanted to wrap in matte black, but I just never got around to it then ended up selling it.
a modified HIV vector?
I strongly disagree with your summary. In studying the evolutionary origins of religion the development of language, in particular writing, which moves religion away from oral tradition, is a key component. Did I articulate this well? No. The science remains well reviewed on this topic though, (that writing was first used for business transaction accounting, and later for ritual purposes).
If I remember correctly this is actually normal for CC processing, because the transaction is so much higher then usual, they are holding aside the money in case it gets charged back. Not like PayPal where they silently ban the account and money disappears forever, could understand it being pain if your a small business.
Elon Musk Crafts New Master Plan Before Tesla Pulls Off the Old One
is it an "expression of anxiety veiled as fact" that my friend was stabbed for his phone by one of these "unhoused"?
If it were Trump in office, that article would been disembowelled all over Twitter
> very difficult crystal structure experiments?

Apart from X-ray crystallography there are other methods for structure determination such as nuclear magnetic resonance (NMR) or cryo-electron microscopy (cryo-EM). The latter has seen a dramatic improvement in resolution over the last decade.
https://en.m.wikipedia.org/wiki/Protein_folding
Noticing something didn't happen is much harder than noticing something did, particularly when you are sleeping.
I would be interested to know if it's been fixed. I don't have time to dig into it right now, though.
I think both things can be said :

1) Gawker got what they deserved
2) The legal power of the very rich makes me uneasy, and I don't support such unilateral over-use of the legal system by the very rich.

In other words; Gawker got what they deserved, but I don't agree with the methodology behind the counter-attack -- I see it as abusive and indicative of a system that is tilted for one side to win more easily.
Maybe, but only if there's a big leap in propulsion technology, and as far as I know there's not been anything big in that regard in the past 50-odd years. Closest thing is probably reusable rockets to reduce cost.
I like the idea.

It's a fairly fundamental change, though. I'm not a compiler person, so I don't know how much cheese it would move. It also may argue with some of the built-in optimizations.

If you want to see these in action, run the symbolic debugger in release mode.
> there is no field.

You obviously mean "there's no field fulfilling criteria X that I haven't spelled out".

VR predates Meta's acquisition and took far less than "tens of billions" to get to commercial readiness. Several small-ish companies have got products to market. Heck, even Google's half-hearted attempts resulted in a fairly decent 6DOF headset.
I still find it fascinating how confidently people are willing to put out comments with all sorts of strongly worded claims about things they are not knowledgeable on, that turn out to completely wrong.
you mean Julian Assange? looks like your Autocorrect messed it up lmao
Gawker boasted that they won’t remove the video, no matter what, even after Hogan asked them. They 100% deserved what they got.
I'm more of an "open borders libertarian" so by all means let everyone come in, but this here is a silly argument. If an immigrant comes, they're either going to get a job, or not get a job. From the point of view of someone who's opposed to more immigration, neither outcome is good. I fail to see a contradiction.
It's not an urban legend or superstition. It's a function of the lizard brain. It adds an extra "interesting" attribute (many things can do this, color is not the only one) that makes you more likely to get stopped. It's the same reason fishing lures are painted brighter than the natural colors of the things they are trying to emulate. It makes the brain go "hey what's that?". In both cases the object cannot trigger the "prey" workflow if the brain doesn't notice it.
Thing is I don’t think there’s a fact-based argument in favour or against either position right now.

You feel that self-driving trucks will be solved with a $100b-$1tn investment

I feel like that simply won’t happen.

That’s really what this boils down to. It’s ok to fall back on gut-feel on these issues, don’t let guys like Ben Shapiro tell you otherwise :-)
Didn't they say the spacecraft will have to move around to get each pixel? That means the planet would turn between pixels and you wouldn't get a coherent image. It would also take a very long time to cover 10's of thousands of pixels. May need to send many imagers and combine the results...
Besides being less buggy, how is discord better for tech comms?
Louis Rossmann: New York will bankrupt anyone stupid enough to stay
Based on a prior art of classic Soviet children poem:

https://ruverses.com/samuil-marshak/what-an-absent-minded-ma...
Interesting ideas but having listened to a mountain of Tolkien Professor podcasts, I don’t think this is a canonical view of Bombadil. My impression is that he is not evil, he is just so old and powerful that he doesn’t care about power anymore.
Good rec. I'll check it out.
That’s my point. A system where your funds are locked unless your complaint goes viral is a terrible system.
This might be an interesting resource for you: https://pdb101.rcsb.org/
Almost perfect, needs a bit more snark
(I work for Stripe, and since many of my colleagues are currently sleeping, taking the liberty of saying this on their behalf.)

We are looking into things.

As someone who ran businesses for a long time myself, it would be very alarming to me if customers felt they were being ignored while repeatedly talking to people who work for us. If that ever happens, please bring in literally anyone at Stripe, inclusive of other Patrick. Our email addresses are often available through a quick search of HN; mine is (predictably) patio11@stripe.com if you need it.

We don't comment publicly on individual customers. This is an important part of customer privacy and we're serious about it.

Sometimes situations which result in external complaints are the result of a process failure, and in those cases we try to fix the instant case and improve processes in the future.

Sometimes they are the result of a process operating correctly but coming to a result which someone did not enjoy. The record available to the process is often more detailed than the record available to the public Internet, and may include extremely relevant context.
Arktika (2016 Icebreaker)
Yeah, have you heard of that Patent clerk in Switzerland who wrote about what changes when we ride on a train close to the speed of light - even though we’re still not capable of building a train that fast, more than a century after. What a waste.
Yeah I agree, and I don't think it needs to be complicated beyond that point. Him and the other stuff that happens very close to that point (Old Man Willow and the barrow-wight) are just showing that this is a naturally magical world without being tied to just elves and wizards and rings. Unfortunately the movies did away with almost all of that part of the books, making it more like a Harry Potter style of magic: simply that there are indeed magic beings and wizards but generally the world itself is un-magical.
I subscribe to https://www.realcartips.com/news/ to monitor new and used prices.
No affiliation whatsoever.
A quote from Patrick Collison from one of the last "HN support threads":

"We actually have an ongoing project to reduce the occurrence of these mistaken rejections by 90% by the end of this year. I think we'll succeed at it. (They're already down 50% since earlier this year.)"

At this point it is obvious that he/his PR staff are lying.

The only question is: What are some good Stripe alternatives?
Maybe bunch of small claim court cases could straighten them out? If Stripe did something like that to me I would certainly pursue this. My own experience is - I have a web store that sells my software products (we use both PayPal and Stripe) for many years. Size of transaction ranges from $10 up to $7000 (as far as I remember) So far there were no any significand holds / delays.
Guy Steele has fallen much farther from grace than almost anyone has risen.
Soon people will start disappearing from photos, back to the future style.
You know Stripe didn't go through this guys socials to find all these threads and THAT is why they locked him down, right?

Stop victim blaming and throat goating Stripe, it's disgusting.
I’ve found rust incredibly portable. I’ve hacked around running the same server side app on the web (WASM), PC/Mac/Linux, iOS, and Android. Another project is a web app running on iOS and Android leveraging a SQLite DB.
> thought 5 minutes passed, only to realize it’d been hours.

When my son was eleven, I took him on a flight from NYC to JNB. He passed out after the dinner service, somewhere near Bermuda. He then complained to me that he couldn't get to sleep... as we were just crossing the coast of Angola. He absolutely refused to believe me that he'd been asleep for about ten hours.
Martin Kersten, creator of MonetDB, has died
> The transaction would also cost less energy than it did through Stripe

Citation very much required.
Not if the rest of the world is at 30%…
Who the hell is Tom Bombadil?
https://www.dogsbite.org/
To all of the people who think devs should know this:

Should devs also know economics and philosophy and English literature?
It’s because the media leans democrat. But make no mistake Fox News, BBC, and other moderate or right leaning news sources will call this a recession.

The news has for the most part has not called out Biden’s many missteps. Not even John Oliver is making fun of it.
Ah! Thorough, helpful and interesting answer.
Not according to many commentators on CNBC.

I don’t understand all the details.

Personally, I think it would be great to understand the economy at a more basic level rather than what’s put out for the general public to consume in the often overly simplified terms.

For example, the condition of the economy vs the Fed raising rates will be interesting.

The Fed is trying to slow the economy but much of the inflation problem is supply side related.
Yes, and even people like hulk hogan without the support of money are nothing against corporations like gawker.

The power scale is kinda Hulk Hogan < Gawker < Peter Thiel < pether Thiel + Hulk Hogan.

But in the end power (and money) are always amoral. Its their use which defines it. The only shocking thing is that justice is not free (even in countries in europe where education and healthcare are...).
While riding bikes is a part of how we get around, going for a tempo ride alone or with a group is not part of my routine anymore. I hopped in the Monday Night ride last week for the first time in ~3 years because my wife agreed to handle bath/bed on her own ( I got back in time to help get my son down to bed )

These are the trade-offs. I can hop on my bike mid-day when they're off at a park, and I have a break in meetings, but that's incredibly rare and not a schedule.

We recently bought a rowing machine to help with the regularity part of our fitness. Not needing to leave home is certainly easier than having to go somewhere with kiddos.
The first offer would have made sense if it was 2X the Raleigh salary.
Imagining either crypto to crypto, or a permissioned rollup handling crypto to fiat that lets the sequencer block a users address for KYC purposes, but user can still trustlessly withdraw funds to mainnet.
For potentially 120 (+30) days? That's 5 months. Some people have to survive paycheck to paycheck!

A delayed payment must not exceed 2-3 weeks tops.
In theory bytes can be a different size, and 8 bits is an octet. But any modern computer, at least those most people will ever come into contact with or hear of, have 8-bit bytes. So while 8 bits = 1 byte should be common knowledge, knowing about other byte sizes is esoteric knowledge.

What systems are there with such large bytes?