skysight-inc/HackerNews huggingface dataset:
Additionally, folding doesn't focus on what matters. Generally you want to understand the active site, you already know the context (globular, membrane, embedded, conjugated) of the protein. It is interesting whether the folding could help identify active sites for further analysis. But -- I don't think alphago is identifying new active sites or improving our understanding of their nuances.
I used to host this article. Somebody in Italy claimed to own the copyright ("literary heirs" of Carlos), and demanded I take it down, despite that Carlos clearly wanted it distributed far and wide. He's dead now, so he gets no say anymore.
First, that seems to be what happened to OP. They suspended the transaction and are holding funds associated with that transaction.

Second, I posit that having even one (confirmed) suspicious or fraudulent transaction increases the likelihood of having others.
> {i,mac}OS dev

I like that. I'm stealing it :)

> Happy to expand more on what I like about using Swift if you’re curious.

Please! I was very excited with it at the beginning, but the few times I dipped my toe it was frustrating and slow.
Stupid is often a product of dumb plus narcissism, a stubborn unwillingness to learn.
My understanding is that having an MBA is useful for getting certain lenders to take you seriously as a businessman, for the purpose of getting loans.
My 4G setup for working remotely from anywhere
The app looks yummy!
They quite literally do, but that’s the point (though I’m using that liberally; I’m not intending to argue the semantics of “life”). Preventing children from being born with an awful quality of life is just as/more beneficial than preventing people from taking up vaping.
How many of those people would have picked up cigarettes if vapes never existed? Probably a bunch.
This is part of the problem that the parent comment is referring to - putting all conservatives under the same umbrella. Tea party is different from most Trump voting working class. Conservatism in recent era has taken a very distinct shape and failure to understand this by elites have led to this very phenomenon the comment you replied to is referring to. How do you explain a non-negligible part of middle of America who voted for Obama voting for Trump?

As far as I am concerned, Tea Party acted in a capacity within the institution. The stuff we have seen under Trump including leaking secret military orders just to bring Trump down shows an absurd amount of collusion of institutional bureaucracy, media, corporate powers and security forces (such as FBI) which was unthinkable a decade ago and erodes the core values and credibilities of those institutions. For example, a decade ago FBI was a revered institution by conservatives who would go at length to support its over reaching acts and its the liberals who would question them. How did the table turn so bad that FBI is now actively being used as a force to silence opposition arresting anyone they like in the middle of night in their underwear while inviting media camera crews?
The thing is, he didn't need to be in the movies _per se_ --- they just needed to have the Hobbits swallowed up by Old Man Willow, then fade to black, then they awaken on the Barrow w/ a couple of swords, and the ponies tied up nearby, and a figure riding away on a pony humming/singing a tune.

Folks who had read the books would know what had happened, folks who hadn't would just have to accept it as a magical incident/rescue w/o explanation.
You realize big hedge and mutual funds have started including ESG in their shareholder prospectuses too?
No wonder my error logs were clean. I can get into my hosts, but my LB isn't routing. Sad face.
Yes, that is it, sorry about the wrong naming.

Around 4 minutes into it.
That is the wrong solution. There is no evidence that corrupt behavior decreases when wealth is increased. In fact there is evidence to the contrary. A congressperson that can accept bribes with impunity will continue to do so on top of a larger base salary just like they did on top of a lower one.

The real solution is to actually tackle the corruption it self (as proposed by OP).
Started sponsorships in January of this year (2022) and it has been sold out ever since. Pricing started at $150 for the first month and has been $250 ever since.
Looks interesting. So is Google basically "selling" the ability to make your own ASICs? Or am I misunderstanding?
US nuclear power: Status, prospects, and climate implications
if you think you need to invest years of time and money to learn to become business savvy then perhaps you are too fearful to be effective as an entrepreneur.

id learning account and economics though as someone else said. i took them at uni as elective courses. but local community colleges usually have them as well.
I'm intimately familiar with the history, thanks. I'm not expressing doubt in you, but about your acquaintance, and whether religious identity alone was enough to get other people murdered on the spot as he told you. Also it's hard to square his support of national socialism in Germany with support for the IRA, as Irish nationalists tend toward being old-line socialists/trade unionists.

Irish nationalists had opportunistically friendly relations with Germany during WW1 but not really during WW2, and most Irish that traveled to the Spanish Civil war fought on the Republican side, though some threw in with Franco because of his support for the Catholic church.
> "highly regulated"

In favor of whom? Because I don't think it's in favor of the average American. IMHO, highly regulated would mean that 1. stock exchanges can't halt trading (eg robinhood) 2. People in positions of power (eg Nancy Pelosi) wouldn't be able to make any money from the stock market.

Obviously, coinbase can stop trading on their platform, but I don't have to use them or even need an exchange to trade on. The only insider trading on BTC would be lawmakers or a whale attempting to alter the price.
> content is worth it so the user would pay to access it

Users have very widely varying amounts of money. Universal paywalls would hit poorer readers far harder than richer ones. They would also push towards centralization via bundling.

> micropayments which browsers refuse to natively implement and automate

I have yet to see a good micropayments proposal, despite 25+y (https://www.w3.org/Conferences/WWW4/Papers/246/) of work on the project. Among other things, they tend to have similar privacy properties to third-party cookies ("third parties can learn every site you visit").

> content is worth it and it is not behind a paywall (this is what most high quality content on the web is actually nowadays - wikipedia, hacker news or your own blog and blogs of many other people are examples)

Hacker News has ads (paid links on the front page for job openings), and Wikipedia has fundraising banners (which many adblockers block). My blog is funded just by me as a hobby project, yes, but most of what I (and I suspect you) read on the web isn't.
Patio11 is one of the most responsive public internet users out there. On twitter, he’s not the absolute most responsive, but he has a standing invitation for anyone to contact him about nearly anything on his website, and he takes it very seriously[0]. I know multiple people at Stripe who have been asked to look into things he’s found out about, and he follows up. I won’t claim that he’s perfect about this, but I struggle to come up with anyone at any company of remotely similar scale that is more likely to do this.

Disclaimer: I’ve somewhat recently gotten to know patio11 a bit, but he’d previously responded to my tweets and replied to my emails, long before our paths actually crossed.

[0] https://www.kalzumeus.com/standing-invitation/
All the currency in circulation rubs up against currency that has been contaminated by drugs. It’s particularly an issue with one hundred dollar bills, which tend to set off the drug sniffing dogs.

https://www.marketwatch.com/amp/story/this-is-exactly-how-of...
I mean in your mind ... if all the economists you saw in leadership positions in the US were black I suspect you would think that's notable. That was the thought exercise I was asking you to do.
Cloudflare uses AWS? For what?
Probably from what follows: “ It's nothing. Really one of the least important problems ever.”

Just because you feel that way doesn’t mean others do. Everyone parents differently. This is an optional feature that you don’t have to turn on and is off by default.
Congrats on the launch!

How do folks deal with the latency of not being able to run EdgeDB on the same server as their managed Postgres service (e.g. RDS)?

Full disclosure: I work on SpiceDB[0] which is a fine-grained permissions database. SpiceDB can also be backed by Postgres, but we form a distributed cache with our database instances so that trips to the datastore (e.g. Postgres) are avoided at all costs.

[0]: https://github.com/authzed/spicedb
ClarisWorks was an amazingly easy way to ween tech illiterate people into a tech workspace.

I’ve seen a required tech course for education majors take people who literally did not know how to use a mouse from zero ability to being able to develop a variety of quite good multimedia projects using ClarisWorks.

It was like witnessing a miracle.

Thank you, Bob!
Most money is contaminated with drugs anyway, it doesn't prove anything [1]. Even if the money was contaminated with excessive amounts of drugs, what does it prove? That the owner of the drugs had a drug habit? That the money originated from somebody who had a drug habit?

[1] https://en.wikipedia.org/wiki/Contaminated_currency
Had Rackspace login issues earlier today. Hmmmmmm ...
yes - we definitely forming in-group / out-group, and in fact being additionally intolerant to those who are resisting being so grouped
Good insight. Thanks for the different take on this situation. After thinking about this, I tend to agree. This could be happening in the background, unconsciously, without anyone noticing. Maybe this will be the on of the catalyst's for change.
> That's no way to run an open source project.

The way contributions are accepted (or not) is completely unrelated to the project being open source or not. It's always up to the maintainer to decide whether a feature should be merged or not. Open source projects are not popularity contests.
EdgeDB is super efficient in its communication with the postgres backend. Most of the time there's only one roundtrip for any query. So chances are, because of how you can pipeline many operations in EdgeQL into one single query, the latency is still going to be far better than a typical ORM+Postgres combination.

That said, we're working on our cloud, all hands on deck. There you wouldn't have any additional latency.
The other good one is identifying people for me at a party who I'm pretty sure I've met before but just can't place!
Wow this is tragic. Of course vehicle crashes happen all the time but Tesla certainly has a target on its back with all the autopilot testing etc.
Motorcycles are often difficult to see (but in this case it seems like the motorcyclist should have been seen as the Tesla hit it from behind) - but motorcycles are often easier to “hear”. I wonder if autopilots utilize any sort of Doppler or sound input to make spatial decisions?
At the very least the Tesla driver remained on the scene…
Suggest you ask on Reddit too

/r/fatfire
The lawyer's time is neither endless nor free, but one can have endless and "free" money.
Yeah, this is how I read it as well. The fact that I was trying to buy something from the bodega owner is I think what tipped them off that I wasn't supposed to be there. The place was clearly closed for regular business.

They definitely didn't want to have to call 'cut' in that moment -- you've already set up the shot and have J Lo (and I think Ray Liotta) doing their thing. Starting over isn't ideal (but probably not a huge deal).
Per the article, they should reformulate to one of the many known-safe ingredients that don't actively destroy lung tissue, and the FDA shouldn't have inexplicably delayed the requirement for five years.

Also, law enforcement could enforce existing laws against marketing tobacco to kids.

The most effective cessation flavor is supposedly "unflavored". I believe it's been banned (in the same way that strawberry lime pomegranate is "banned" -- not very effectively).
Check out sqllite codebase. It has a lot of tests. If you want to try test driven development there are books like Growing OO Software with Tests, and TDD By Example.
I'm unfamiliar with this product/feature, but does this mean I can choose which CA mints my cert? Or is this just a pool of CAs Cloudflare can draw certs issuance from?
Doesn't surprise me that Alex didn't go nuts to make his space look "perfect." I met him a couple years ago back and he was a really nice, smart, and incredibly authentic kinda guy. It even comes through in his interview:

"Some sort of ergo-friendly chair that I bought online"
"Apple Watch in case I work out"
> It was never intended to be a true democracy

Agreed. And it's interesting that (collectively) we like to believe it was.

> there have never been true democracies that scale up

I'd put modern Switzerland forward as an example of a democracy that has scaled, perhaps to the extent a fair democracy can be scaled. It's a country of 8.5 million people, speaking several languages, split into 26 cantons, and further into local municipalities. There's a tradition of defaulting to local rule. Cantons are the size of counties in the U.S. but are more powerful in some ways than U.S. states - they collect taxes, administer health care, etc. If you don't like something you can lobby the representatives of your canton personally. You may have even gone to school with the people serving there. And the people have the power, at every layer of government, to petition for a referendum to add or delete any law or amendment. The politicians respect that the people can veto them. [0]

Political scaling is an interesting topic. Leopold Khor wrote a book called "The Breakdown of Nations" which talks about how bad the scale of the modern nation-state is, the brainwashing required to sustain such an unnatural construct, the bullying that inevitably ensues given such a concentration of power, and, like you said, the loss of anything resembling a representative democracy, an inevitable slide towards authoritarianism. [1]

[0] https://wolf-linder.ch/wp-content/uploads/2010/11/Swiss-poli...

[1] https://www.youtube.com/watch?v=gaszpQaNwAU
> Why does everything you personally don't agree with have to be a "conspiracy theory"?

This literally invented false historical facts (about the historical official definition of a recession) to support a claim of a political conspiracy (of the media doing Orwellian thought manipulation through language redefinition to support a favored political faction.)
The one-sidedeness is that the poster could be lying, and Stripe isn't allowed to call them out
To perhaps be a bit more constructive, and to suggest a way forward...

I'd like to see a cooking teaching app that allows users to work through a recipe in varying levels of detail. For example, consider a Lasagna. A lower level recipe may use ricotta for a quick and easy version, a higher level might explain step by step how to make a bechamel, and the "hardest" level may just say "make a bechamel".

As a user, being able to select a difficulty level and see the differences not only allows me to learn new techniques at a pace that suits me while experimenting, it also teaches me more about the dishes and how recipes can be changed while keeping the spirit of a dish, or the flavour profile.

The best cooking videos on YouTube, people like J Kenji Lopez-Alt and Chef John from Food Wishes dot com, tell viewers what's truly necessary, and what's not. What "makes the dish" and what they're replacing in the recipe themselves because they ran out of the proper ingredient. I've learnt so much from this sort of thing, and am far more confident both creating my own recipes and modifying existing ones, having been a to-the-letter recipe follower for many years.
Withdrawal limits? Sometimes it does seem like they are re-inventing banking.
Lago founder here. FWIW we love what Baptiste did with Microinvoice!

I can only speak for what we've experienced first hand, in our prev. company (a $5B B2B fintech) we spent a lot of time around billing x invoicing in pdf :

- When billing is complex (lots of fees, different billing cycles, usage based consumption)
- And you need to have a clear "invoice presentation" to avoid triggering questions (that is maintained while you iterate on pricing, launch new products or countries)
the "template isn't really a solved problem", and our eng. team did rebuild the system in-house. We would have avoided it if it could have been possible and looked at every possible option, in-depth.

We've seen similar needs for marketplaces or vertical saas as well.

However thanks for the feedback, we could have done a better job at explaining why it can be a pain in specific use cases! And I was the 1st person to say, when I first discover the painpoint "there must be an existing solution for that, please don't build anything in-house".
Having any object / table in Salesforce > 1M rows is somewhat exceptional; doing that daily (using standard Salesforce capabilities) is off the charts -- just moving amount of data into Salesforce within a 24 hr window is questionable. Its built for B2B, where the data volumes are much lower, and conversely the kinds of operations / workflows you want to do on that data are typically more complex.
In NY the film crews out up emergency no parking signs 2-3 days in advance which 1) are issued by the police; 2) describe the time and date of the shooting and name of the production; 3) list the name of a production assistant in charge and a cell phone number. Seems like a pretty good compromise.
us-east is a geographic distinction within which there are multiple regions. us-east-1 and us-east-2 are not the same. This outage occurred in us-east-2. Within an AWS region there are multiple data centers. They call their data centers availability zones. The availability zone AZ1 was the one impacted, and within that availability zone, most likely only a subset of servers.

us-east-1 is the region you're thinking of that has issues. Mostly due to being the largest region (I think?) and like you mentioned, the oldest.
Secret voting is one of the characteristics of sortition[1] governance systems.

Just like on a jury for a court case, people are randomly selected from the population to sit on the legislature. They naturally vote their conscience, and when their term is up, they go back to their normal life. Because compliance with a bribers' instructions is unobservable, bribery is not incented.

The beauty of it is that you don't need to hold anyone "accountable" because there is no election, only random selection. Of course, the devil is in the details. Should prisoners be eligible for selection, or the illiterate?

[1] https://en.wikipedia.org/wiki/Sortition
Plan B? Vapes are making them more money the money then it's costing them. And they were already an industry dying out (in the US) as new smoker numbers kept dwindling.

Meanwhile, they own the biggest vape companies.

And I don't see what inconsistent positions are taken. If you tell me them, I'll gladly tell you why.
1. Evidence based psychology is legit. Non-evidence based psychology, probably not (except for coincidence).

2. Same with other fields, which ironically may not suffer from the same credibility problem (notably medicine).

3. The Alzheimer's thing was about outright fraud. Totally different kettle of fish.

4. All sciences are human sciences.
this is an interesting conundrum, similar to the paradox of tolerance. In the end, we will likely draw a line based on an arbitrary rule, like any authoritarian would
I could not afford my life on a senator's pay. Not even close. Couldn't take the job even if it was offered to me on a silver platter.

President's pay comes with housing so my family could probably make that work, would be belt tightening--especially because I'd be on the hook for the food in state dinners and such.

Not that I think anyone wants me to be a senator or the president but rather I couldn't afford to be. I'm too wealthy for it to be an upgrade and too poor to take the pay cuts in stride.
Exactly. The film crew should have had the contextual awareness to block off the area and respectfully inform people to go around if they didn't want people walking through. It seems like they didn't have at least the contextual awareness. From the pictures, I doubt I would realize it's a film set.
I don't have experience with GDScript, so please forgive the ignorant question.

Does GDScript have good debugging, linting, and profiling tools?

I'm not a game developer, but I'd love to hear your perspective on some of the criticisms I've encountered on the topic of scripting languages for game development.

One of the main criticisms I've heard of using scripting languages for game development is that they tend to be lacking when it comes to tooling.

The second form of criticism I've heard is that type issues become a serious problem as the size of game code growns past a certain point.
The light/dark toggle on the site doesn't work for me?
I think any system is susceptible to problems like this if the underlying hardware becomes unavailable. Using dynambodb to obtain locks on s3 is a pretty common pattern in AWS development. This has more to do with AWS than Terraform.
But animals don't synthesize B12 either, they only store the B12 that they consume. There's no benefit not to just consume it ourselves.
A device-independent quantum key distribution system for distant users
This possibly the worst way to "trim", because it's not the low performers they will be trimming off, it's the ones who are bad at politics or networking will be let go.
Source?

My understanding is Google wants pages to be different and have a lot of keywords.

If you have a generic recipe website with just the simple cooking instructions:

1. it's going to have less key words

2. it's not going to look different from hundreds of other websites like this
I run Payload (http://payloadspace.com/). We are a media company covering the space industry. Congrats on all your success so far. For those reading this, there is a lot of riches in the niches. Just choose a topic that you don't think gets a lot of coverage and start writing about it. Two areas that come to mind:

- Geospatial
- Nuclear Energy

Media/content -- to Ryan's point is being consistent. As long as you do that once you have PMF, you'll grow and make money.
> us-east-1 is the region you're thinking of that has issues. Mostly due to being the largest region (I think?) and like you mentioned, the oldest.

Also, because shared and global AWS resource are (or at least often behave as if they are) intimately tied to us-east-1.
> demonstrates how AI can already outclass humans for certain tasks

I'm not sure how clear the edge over humans in this case is. There were some attempts at machine assisted human solving like Foldit that did produce results: https://en.wikipedia.org/wiki/Foldit#Accomplishments
> I wouldn't want a browser, for instance, integrating "go get the mirrored content from another site" or "mirror paywalled content to other users"

Why not? It sounds like if you accept the role of the browser as "do what is best for this specific user despite the broader consequences" they're worth doing?
> We offer (human-powered, somewhat obviously?) support via a variety of methods 24/7

> time for us to reply to email is generally a few minutes

These two assertions are conflicting. A few minutes is not nearly enough time for a human to understand and address a support request. So like most companies, it sounds like Stripe is actually running automated support behind a fleshy humanesque interface. Don't delude yourselves into thinking that this counts as "human-powered" support.