skysight-inc/HackerNews huggingface dataset:
I've directly communicated with the leaders of CASP and at DM that they should stop representing this as a form of protein folding and just call it "crystal/cryoEM structure prediction" (they filter out all the NMR structures from PDB since they aren't good for prediction). They know it's disingenuous and they do it on purpose to give it more impact than it really deserves.

I would like to correct somethign here- it does predict structures de novo and predict folds that haven't been seen before. That's because of the design of the NN- it uses sequence information to create structural constraints. If those constraints push the modeller in the direction of a novel fold, it will predict that.

To me what's important about this is that it demonstrated the obvious (I predicted this would happen eventually, shortly after losing CASP in 2000).
Yes, he is the GMPC in a RPG setting. As this is heroic fantasy with few or no subversions to the plot ever, the other characters are written as not meta enough to note that they are in a story, and the author of the story put his avatar in there.

As to what a GMPC is:
https://tvtropes.org/pmwiki/pmwiki.php/Main/GMPC
I believe the parent is being sarcastic.
That is a good politically correct line, but accumulated injustices do find uncontrolled release when the justice infrastructure ignores them long term.
> Every third-party “tool” is actually a weakness: it’s doing something that either didn’t need to have been done at all, or could have been done better in the first place.

That's a rather absurd proposition. The number of problems a programming language can be applied to is infinite, and span virtually all domains of knowledge. A core dev team likely isn't even capable of making every necessary tool, the idea that they would always make the optimal implementation is laughable. And of course every user will have a different definition of what is necessary.

The key to creating a great community is not to build lots of broken things to fix, but to build a strong foundation that makes building easy. A language can be lacking many important and useful features but so long as it has well thought out standards and a commonly understood vision, the easiest and simplest way to extend its capability is to remain consistent with other language features. These consistent third party tools make the language more widely applicable and easier to further extend.
>but to write a serious game you really want C#

I haven't followed game development in a long time, but has the industry moved to C#? I thought C# was limited to Unity and everyone else was still using C++?
All things being equal, more people working is a an increase in buying power. The decreased buying power of wages is only negative relative to the amount people being paid a wage. Which itself is a function of both employment opportunity and size of the labor force. The recent rise in inflation is definitely correlated with a rise in wages albeit at a slightly lower rate resulting in a roughly 1% lag in the past year. If you map out wages paid per GDP you can get an idea of how much of a share of economic growth has been going to workers and it's a been a pretty solid, steady decline since 1970:

https://fred.stlouisfed.org/graph/fredgraph.png?g=Sfun

So, that sucks, but it doesn't make a useful definition of recession. This is the result of massive, global macroeconomic forces. It's basically a slow reset of the post-WWII global order.
I don't know. I was addressing the question about the lack of infected source animals. I tried to make that clear by quoting the point that I was replying to.
Not sure if you should be reminded of how alpha fold started, it started by winning a competition thought un winnable by academics. Top labs working in protein structure prediction have fundamentally changed direction after alpha fold and are working to do the same even better.

This is not the first (or even tenth) time I’m seeing an academic trying to undermine genuine progress almost to the level of gaslighting. Comparing alphafold to conventional homology modeling is disingenuous at its most charitable interpretation.

Not sure what else to say. Structural biology has always been the weirdest field I’ve seen, the way students are abused (crystallize and publish in nature or go bust), and how every nature issue will have three structure papers as if that cures cancer every day. I suppose it warps one’s perception of outsiders after being in such a bubble?

signed, someone with a PhD in biomedical engineering, did a ton of bio work.
I had to tell a couple people (generally college aged) to skip that chapter in order to get them to continue reading the books (around the time that the movies were coming out), as he wasn't important to the rest of the narrative.
I know I was questioning if I wanted to finish the books when I read that part in 6th grade. The rest of it obviously made up for it.

From your link, the set of comments under the first answer also shows there is clearly a debate.
When I was reading the story I could understand that the descriptions of the country side were just for setting the scene.

Whereas this guy takes up pages and pages, to ultimately have no effect on the story at all? Felt like a bait and switch to ten year old me.
The Wiki page says it already supports C#. As completely on the outside, what is missing?
Yep! You can connect to custom API endpoints from the dashboard or add custom code via our embed SDKs https://docs.feathery.io/develop/react/onsubmit
I do the same. I either have a flashy top, or a flashy bottom. And I love it, because it gives more occasions to get compliments. Not only people can comment about how the clothe fits, but also how the color highlights my skin (I'm pretty tanned all year round, and flashy colors makes it even more stand out).

But yeah, people are afraid of standing out. Once a friend told me he'd love to do the same, but he did not have the guts to do it, so he keeps wearing dim clothes.
Should Joe Biden get some streamers and make a poster to show his support for oil refineries? He isn’t in charge of spending; that’s Congress. Maybe he should issue an executive order forcing oil refining capacity back online? Then you’d bitch about government overreach.
Presumably people weren’t wedded to colors in the past either.
1) Isonet - takes low SNR cryo-electron tomography images (that are extremely dose limited, so just incredibly blurry and frequently useless) and does two things:

* Deconvolutes some image aberrations and "de-noises" the images

* Compensates for missing wedge artifacts (missing wedge is the fact that the tomography isn't done -90° --> +90°, but usually instead -60° --> +60°, leaving a 30° wedge on the top and bottom of basically no information) which usually are some sort of directionality in image density. So if you have a sphere, the top and bottom will be extremely noisy and stretched up and down (in Z).

https://www.biorxiv.org/content/10.1101/2021.07.17.452128v1

2) Topaz, but topaz really counts as 2 or 3 different algorithms. Topaz has denoising of tomograms and of flat micrographs (i.e. images taken with a microscope, as opposed to 3D tomogram volumes). That denoising is helpful because it increases contrast (which is the fundamental problem in Cryo-EM for looking at biomolecules). Topaz also has a deep learning particle picker which is good at finding views of your protein that are under-represented, or otherwise missing, which again, normally results in artifacts when you build your 3D structure.

https://emgweb.nysbc.org/topaz.html

3) EMAN2 convolutional neural network for tomogram segmentation/Amira CNN for segmentation/flavor of the week CNN for tomogram segmentation. Basically, we can get a 3D volume of a cell or virus or whatever, but then they are noisy. To do anything worthwhile with it, even after denoising, we have to say "this is cell membrane, this is virus, this is nucleic acid" etc. CNNs have proven to be substantially better at doing this (provided you have an adequate "ground truth") than most users.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623144/
from the first paragraph: "Imagine a dystopian future in which aliens with a taste for human flesh kidnapped a bunch of people from Earth and raised them as livestock on their alien planet. Humans on the alien planet are kept alive “free-range,” able to interact and live their life, but only for their first 20 years. Then they are harvested for food."

yeah, its "The Promised Neverland"
Nobody uses Rust for server side, literally nobody, expect Meta apparently

The industry adopted Go as the cloud native language, not rust, i suspect the people doing the recomandation are ex-mozilla, or they literally HATE Go
It has template structures. AlphaFold uses the following databases:

BFD,
MGnify,
PDB70,
PDB (structures in the mmCIF format),
PDB seqres – only for AlphaFold-Multimer,
Uniclust30,
UniProt – only for AlphaFold-Multimer,
UniRef90.
If you don't have the luxury of managing all your systems within one organization, then time smear is the least of your problems. Day-to-day ntp drift alone will be a bigger problem.
A meaningful life is impossible without suffering.
Perhaps G.R.R. Martin?
>How is that prevented now?

people are generally a lot less brazen towards other humans compared to how they interact with automations or things that are remotely surveilled rather than with a human attendant.

trains with unarmed guards generally don't get robbed.
As a pragmatic software engineer: same. The code by default era can’t end soon enough, we shouldn’t be carrying the burden of our own inferior versions of things that already exist. A decade from now we will look back on the amount of code written now as a puzzling artifact of the past.

Code when a ceiling has been reached with existing tools is the future — a ceiling which is getting higher and higher, thanks to Retool etc.
I always think a simple measure that would fix the toxicity in social media is to adopt the "right to answer" that worked for ages in the newspaper business.

It works by obliging the newspaper to print a correction at the same location as where they published the original piece (that was proved wrong in a court-of-peers of some sort).

It acts as an effective check because the right to answer would reach the same audience as the original fake piece and the credibility of the newspaper would decline.

In social media, fake news spreads virally and there is very little recourse except tweeting a correction and hoping it goes equally viral.

A simple law could require for-profit publishers of fake news to ensure a similar audience (retargeting or newly paid) reads the correction.

That would destroy all the profit of publishing fake news, while reducing the credibility of the fake news publisher effectively.
> nobody pretended to be bothered by it

How often do you get to a successful resolution of a dispute when you start from the position that one side's concerns are made up (pretended, imagined, etc)?

> There hasn't been any notable effort to discredit flu vaccines because they don't offer permanent, or even particularly reliable immunity in the many years that they have existed.

These are the reasons that I never opted to get the flu shot, and I never had my professional and social lives threatened as a result.
AlphaFold figures out that my input sequence (which has no structural data) is similar to this other protein that has structural data. Or maybe different parts of different proteins. It does this extremely well.
> You've completely lost your voice

Well... that's true, but it's also the way things always were until very recently.
Congratulations on the funding! I built multiple unusual internal apps for our product last year. Retool is now in my list of "must have" for any thing I build.

The build process took a bit of time and I had to hire an expert on Upwork. Not everyone might persevere. A gallery with examples of varying complexity would make the sell easier.
Actually, just ask to be an extra. You will get paid, fed, and get to hang out all day on set.
Figure 1A shows 120 cases from 2019 with no known link to the market, yet they cluster about the market. So the allegation of ascertainment bias does not appear to be substantiated.

Further, the criticism of rewording "these analyses provide dispositive evidence" to "these results provide incontrovertible evidence" is bizarre. The term "dispositive" in this context is equivalent to "the last and final word" which in a scientific context was rightfully removed, though it was replaced by a strong assertion.

With these two matters, I did not think the author has sufficient credibility for me to further investigate their claims.
But you need to time the dip with this strategy, otherwise you're underwater in the meantime.

I think the question was, "How can I profit as things get worse?" Or, "What are good ways to protect myself as things go downhill?"

My recommendation? Reduce expenses. And think about investing in ways to reduce those expenses - Toilet paper is expensive, buying a bidet can save money after X uses. Meat can be expensive, see if a farmer in your area is willing to sell you the meat of a full cow at a discount for you to freeze and use over the course of X months.
While certainly not the majority, some livestock are actually treated quite well until the point of slaughter.

On the other side, many wild herbivores and prey animals live lives in an almost perpetual state of alertness and fear, just a moment away from being viciously torn apart and eaten alive.
I'm currently on profile 17a, I pay for 100 Mbit (downstream), and get like 90 Mbit actual IP protocol bandwidth (wget tops out at 10.7 MB/s). But I think the ATM signalling that's still used on the underlying VDSL physical layer is eating a significant portion of the bandwidth (due to the high frame header overhead).
Which is not true either, as the dip we've seen over the past several weeks can attest. We've deeply tapped into our reserves (much more than expected as released yesterday) to achieve this. It seems like it might be short sighted and short lived.

Also if the president has no effect on gas prices why was ours groveling at the feet of the Saudi Prince?
> Ultimately, no one uses Swift voluntarily

I would use it in more places if I could, it's a language I feel extremely productive in. Apple however has shown zero interest in helping popularise it anywhere outside of their ecosystem and left it up to the community.
The justice system is kinda made for handling all these disputes that people can’t talk out themselves. The lawyers are incentivized to drag it out because they almost always get paid by the hour.
1984 does not apply here in any way shape or form.
Yes I guess it comes down to the likely hood of the RAM going bad without the user realising it.

I have had one stick give me issues over the last 10 years but that is out of probably 20 sticks.
Investing in Fly.io
Sometimes people shame of what there wearing colors or something else but you chose what you want! So everyone can wear be what he wants to be/wear.
Its crazy if you think about it people dont like colors because of colors everything is possible.
Its just like gravity.
HACKER501.
Isn’t this TPM in this framework?
You're entitled to your opinion, of course. But I'm still not buying a laptop without one. It's like if I said I want chocolate ice cream and people always have to bring up that they don't like chocolate.

It's a screen. I can see it. I'm quite confident that I want it.
Accidentally walked through the set of The Devil Wears Prada who were set up to film on around 5th Avenue and West 55th, fortunately they weren't filming. They had a really nice craft services table. Hopefully no one got fired.
OK, show me when Twitter official retweeted something calling for white genocide.
Since reference counting is automatic for the most part, the language tries to express the semantics of references itself - for instance, you can capture self weakly for a callback later, and have to check that you still have a valid capture before use.

After that, your issues then are typically reference cycles, which can really only be found by tooling at runtime or by certain linting tools (e.g. warn that the type definitions make reference cycles possible, even if your code isn't making cycles). There are tools such as Instruments included with Xcode to help detect cycles at runtime.
A paper-titled transaction seems like it should have one of the lowest chargeback risks. A copy of the purchase and sale specifying "as-is", plus signed title should be pretty clear cut evidence against a chargeback.

It's also not terribly surprising that someone who develops familiarity with one tool will then apply that tool to new situations. The main problem here is the ever-growing financial censorship regime / decommodification push that insists companies should be prying into their customers' business.
> Never get into a legal battle with a lawyer. You can't win.

My ex wife is a lawyer. I agree with this statement...
As with every philosophy questions have no answers and every argument is drowned in assumptions.
I am italian, and we have always had a good relationship with Russia, either for energy, housing, boats, textile, etc. so a lot of people were not happy of this whole situation
How is this topmost comment?

> If you're thinking about doing like this guy did, please don't.

The author starts by stating:

> The area did not seem to be closed off so obviously I went in to take a closer look.

And

> I was probably there for around 30 minutes or so until someone finally asked me if I was part of the crew and then kindly asked me to leave which I did.

Does one need to go through life like they are stepping on eggshells?
But how can you argue that we're living in a world that's worse than if we hadn't done the stimulus when you haven't lived in that world?
If you’ve ever worked in the real world, you’d know that the technical debt produced by developers who think they can build no-code alternatives in 10 hours is far worse than any technical debt these tools could produce.

10% of the code we write produces 90% of the value: retool etc. allow us to spend much less time on the 90% of code that isn’t valuable to the businesses we work for.
OP was at SUSE when they made an agreement with MS touching on this issue. I don't agree with the OP, I think if there was specific pressure of this sort it wouldn't really be a secret or subject to speculation. My point in all of this is simply that the GGP 3 word comment without anything else is not defensible as a constructive comment.
Why would it be ironic to use a word describing the thing you're talking about a lot?

It seems that if you're talking about polarization, the word is going to come up more than once.
No Saruman vs Gandalf rematch in the original films. It was included in the director's cut but then you could see why they left it out.
So you extrapolate, to the general population, your need for an extra freezer as an obstacle to reducing the cost of buying in bulk but your objection to my comment is that it is not relevant to you in particular?
I wouldn't say I found it buggy, but rather limited. For instance even something simple like a list view has limited customisability, and some of the styling is mandatory unless you want to rebuild the entire component from scratch. It's a far cry from UITableView which can do just about anything.

Also I found that once you get into stuff like animations, things get messy very quickly since everything has to be expressed declaratively. It's a nice idea for simple static views, but I really missed the ability to have separation of concerns the way you can with UIKit.

Also I did find the tooling quite buggy. Like certain things would break the preview, and not give meaningful errors or just crash the Xcode process, so I would have to fix it through trial and error with commenting out sections of code until it would work again.

I am sure it will improve, but with UIKit you can basically achieve anything, and SwiftUI still seems like it has a lot to figure out.

I think it's a shame FRP has basically won front-end at this time, because while it's been a revelation in web (since it solves a lot of the problems which make web a mess) it carries a lot of its own problems, and I think there are going to be a lot of apps which will be horrific to maintain over the next few years.
Those databases are used to derive the evolutionary couplings and distance matrices used by the algorithm. Several of those databases aren’t even structural ones. Furthermore, AlphaFold can function with only a MSA as an input, without retrieving a single PDB coordinate.
Are animals people? For most of human history, the answer has been no.

I'm sure that there have always been humans that thought of their favorite animals as people (or similar), but the scientific and social acceptance of animals having consciousness and emotions similar to humans is VERY recent. Look at the pushback that Jane Goodall got for her research for context.

Anyway, I don't have a good ethical argument in favor of eating animal, other than history and my personal rights. This is similar to my feelings on abortion - women have personal rights, but other than that, abortion is not good.

I'm sure people will have problems with these statements, but please consider that I am not trying to change your mind or morality.
Sure, I was asking if it was worth the better critical thinking if it didn't lead to better life outcomes. It looks like, if there is better critical thinking in Europe it's not leading to better life outcomes. So that means one of two things:

* better c-t does not lead to better l-o

* the c-t is worse

If you feel that World Cups are a better measure than maternal mortality rate, then have at it. The measures we choose are arbitrary, so we can just lay them all out. I'm happy to accept relevant metrics if you have them to show. Personally, I think a society with better critical thinking overall would be able to, given resources, reduce the number of dying new mothers but if you believe there is no relationship I am happy to just accept metrics you offer.
Great question! Not that I'm aware of (EDIT:
sseagull provided a good example in 1947). To be fair, I can't think of any time where we've seen 2 quarters of negative GDP growth while maintaining "full" employment and wage growth. This is an unusual recession if it is a recession.
Thanks for the advice. I've had hearing impairment for about 22 years. My life now is somewhat reclusive simply because of hearing loss. I used to go to clubs but not anymore, I got old. I still own a pair of technics 1210s and working on my own virtual reality turntables (video)
https://drive.google.com/file/d/1uvtDoKJKO0xzIs08g0e_HMDMAna.... I've taught myself to code and create video graphics etc. Allowing me to still be creative. I don't know if i would go the route of cochlear implants, the thought of surgery scares the hell out of me to be honest. I'm used to living the way i do now. I wouldn't wish a lonely life on anybody but you do get used to it. Thanks again for the advice though, i appreciate your effort. thank you!
I think fundraising is more about setting a price on the company. I mean, now we know retool is valued at 3.2 billion, it is probably 20-40x revenue, may be more.