skysight-inc/HackerNews huggingface dataset:
It's the classic chicken and egg problem.

The lookahead only need to be applied to nested selectors.

But you can't know whether something is a nested selector until AFTER you applied the lookahead.
you could sell cheats
> It ultimately relies on mapping sequence to structure.

So does every structural prediction method.

> if you give it a brand new fold with no relation to other folds, it cannot predict it

That will depend on the number of effective sequences, not the actual fold.

> I work in organisms that have virtually 0 sequence identity.

Then the problem is low sequence coverage, not the protein fold. On a side note, there are sensitive homology search protocols that rely very little on actual sequence identity.
It’s funny he mentions most libraries being written by junior developers looking to beef up their resume. Even if we assume this is true, you’ll get some other junior developer writing the same functionality at your company. Except now they have no tangible incentive to write maintainable code.
And that's the point where contextual awareness and respect for others come into play.
The overworked humans behind China’s virtual influencers
Yeah, it sad to think we have 100 f*cking think tanks endowed by billionaires that serve mainly to drive wedges into our democracies, yet nothing like that for PL geniuses that I'm aware of.
Developers are burned out, quitting jobs and creating a crisis for recruiters
GFC = Global Financial Crisis (2007-08)
Full disclosure - I work at LaunchDarkly (I look after our DevRel team) - but this is a topic I'm super passionate about also, so though it was worth sharing out. We talk about burnout a lot - but what I really appreciate about posts like this (and the report that it references) is that it gives some tangible examples of where that burnout comes from - and hopefully some paths to mitigating it.

Hope you find the read interesting!
Everything2 is one of those things that inspired near obsession for me when it was a going thing. I am glad you can still look at it, but it's a little like going to the World's Fair site in New York City. You get the impression this was pretty cool once, but that its time came and went.
Is there something inherent with game engines that prohibits small, frequent software delivery? (call it agile or lean, if you want)
If that is a prerequisite, how do we get there? Maybe it's a forlorn hope, but it's how I imagine the future of the human race.
Although normally the flush toilets empty out onto the tracks, I trust this has been stopped. The track workers quite rightly didn’t like it.

One of the grimmest things at getting off of a train at Liverpool St station is the smell of train loos that had emptied out in the station.

In time I trust it will ebb away.
Yes he believed society should be frozen in time & change prevented. He grew up from a well to do family & saw relatives ruined by tumult. But that reaction he had, to feel that society- a quite inequitable one in his time- should be held frozen in place, guarded carefully against change by citizens only of high metal, is a grossly stasist & crass way to run a planet, to dictate terms to the rest of humanity from.
I agree, but that's kind of what we do to resolve moral cognitive dissonance all the time, with varying results. Personally it's something I really struggle with, and the questions usually boil down to whether I would be fine living my life wrongly, or if I'll give up enjoyment of my already sad life just to feel good about myself for being moral.

I just can't picture it. 9 hours a day in the office, then I come back home and I just want to hedonistically enjoy all that I can until I sleep. Of course I'm going to want to eat a big steak, watch porn, and listen to pirated music, morality be damned, and I know it makes me a bad person.
I am building a site called talentexploit.com since many years now, (I'm working full time, this is my side project) that collects skills, wishes, requirements and all sorts of stuff from people and based on that recommends career paths along with suggesting education ideas to achieve that goal. This is because 9 of 10 people I meet don't do for living what their hobby is, or what they like to do in their free time. They feel shit and bored at workplace. This would be for them to advise how to change. But will never go live, because it's huge for a junior dev like me.
What did you write it in? Was yours similarly slow?
Show HN: Parsnip – Duolingo for Cooking
We're building Parsnip to create a "tech tree" of cooking skills that allows anyone to level up on the building blocks of cooking knowledge while tracking their progress over time. It took us a few iterations to figure out the right product; here's the story of our latest pivot: [https://parsnip.substack.com/p/a-new-hope]

The goal is to create a personalized way to learn any recipe on the Internet, then use this as a springboard to help home cooks of all levels solve the problem of repeated meal planning in a 10x better way: [https://parsnip.substack.com/p/vision-part-one]

We believe that solving this problem at scale is good for people and for the planet [https://parsnip.substack.com/p/why-we-started-parsnip] and that now is the perfect time in history to do it: [https://parsnip.substack.com/p/why-now].

Would love any suggestions, feedback, or advice; and happy to answer any questions!
You start with:

> I don't believe social media gives us a glimpse of democracy, but rather anarchy.

But it seems like the conclusion you reach is that it's tyranny. Do you view anarchy and tyranny as the same thing? Or would you view them as opposites, or somewhere in between?
If we didn't eat meat, we wouldn't be so smart.

http://news.harvard.edu/gazette/story/2008/04/eating-meat-le...

http://www.npr.org/2010/08/02/128849908/food-for-thought-mea...

http://www.sciencedaily.com/releases/2012/04/120420105539.ht...

http://greatist.com/health/eating-meat-build-brain-121112

http://www.beyondveg.com/billings-t/comp-anat/comp-anat-4a.s...
The article contains reasonable advice, the basics are covered.

It's quite ironic though, that a page about readability and accessibility uses gray text on a white background. For me it's well readable, but probably not for people with low vision.
> That's HUGE, and the direct actions of the administration are to blame for this.

I’ve been hearing from some people that the rise in gas prices is this administration’s fault.

However, when I look at prices here in the EU, gas prices have risen much more. Is that the current US admin’s fault as well?

What specific tools should the exec use in this situation? EO no more oil exports? EO limiting the record petro industry profits?

What is the complete argument for why this is Biden’s fault?
Tolkien either defined or at least cemented what Elves, Orcs, Dwarfs and Halflings are like (including their culture, environments and architecture). Almost all of fantasy is keeping more or less close to those definitions.

If this influence continues to hold, then the popular fantasy VR reality doesn't need to be Tolkien World. It can stand completely on its own and still generally look and feel like Middle Earth would.
(not "computer science" but web development)

Middle school, there was a summer program that taught how to make a website using Geocities, basic HTML and CSS. It was magical to SEE something I'd created, even if it was just a designer's nightmare of a Metallica fansite. We only had something like 10MB(?) of storage, so I had learn quickly about the differences between the image formats that Paint.exe would export to. Problem -> Solution (use jpg). Comparing the size to the quality I learned there were always trade-offs.

20 years later, it's nearly all the same stuff. History's just gone round and round but in the end we're all just trying to share what we like with others.
Even with that aspect, the consensus of what is considered neutral non-offensive household colors has changed from a warm brown palette (off-white walls, brown wood floor or tan carpet, wood or off-white cabinets) to a cool grey palette. That is a big shift. In the 90's or earlier painting a room grey would have been considered an opinionated decision that might turn off potential buyers.
> These algorithms purposefully amplify some of the most toxic content out there

No, these algorithms (often) purposefully amplify content that increases the engagement rate or "average time on page" metric.

It's just that toxic content coincidentally often has high values on this metric:

- if you agree with the content, you stay on the page longer to read more of what you love

- if you disagree with the (toxic) content, you perhaps invest a lot of time to post strong counterarguments (increases engagement rate and average time on page)
well then 'fiction' is fiction so i guess everything is real
Huh, didn't think of that. I'll give it a go later.
Sorry, but that just doesn't compute for me at all. Tom is a silly character with no gravitas. He puns his own name just to make it rhyme with "yellow" -- over and over again. And there is nothing in Tom's story that is even remotely comparable to the Resurrection. The Resurrection is a key event in the Bible story. It is something that happens to change the dramatic arc of all mankind. In Tom's story, nothing happens at all.

The scene at Mount Doom where the Ring is finally destroyed is analogous to the Resurrection, not Tom Bombadil.
The weird, high-stakes world of elite chess
Are you kidding? With the incredible censorship exercised by the social media giants, you think we have unfettered voices?
It rarely has bearing on actually doing the job. But all abstractions leak. Once in a while, the number of bits in a byte leak out.
https://archive.ph/nJtks
The first two paragraphs present such a blatant false dichotomy that I won't be doing myself the disservice of reading any further. If you're going to announce yourself as a philosopher in the title of your blog post, the least you can do is avoid basic fallacies.
> Why would it be ironic to use a word describing the thing you're talking about a lot?

Their position seems to be that polarization (in the sense of the sides being pushed to extremes) is a bad thing, they claim that has happened, and yet they are extremely one-sided.
> But you need to time the dip with this strategy, otherwise you're underwater in the meantime.

Being temporarily underwater is fine, unless you think that economic growth will stop, or you are a day trader.

Dollar cost average if you can.
Then there's nobody who is not sentient, and we need a separate word for those who can, like, talk and use tools.
The question is what would China do if it had America's dominant position and there was and a global pandemic killing 6 million and causing 12 trillion in damage originated blocks away from an American virus lab and animal market.
You likely use "C with classes" C++, so C++03 for the most part, not the generics heavy C++ where you put everything into the header because it needs to be generic. This has massive advantages for compile time. Also "decent size" is a term with many definitions. E.g. Chromium has 12 million lines of C++.
Both great spaces!

That's a good suggestion... I'll see if I can include that a bit going forward.
I agree that we are in a recession.

>How did we get to a point where actual data can be outright denied or absorbed based on your political viewpoint?

Because the actual data is sending mixed signals. People equate recessions with job losses, but job growth is still high and unemployment remains incredibly low. Businesses equate recessions with reduced demand for goods and and services, yet demand remains strong enough to push prices and profits to record levels.

GDP has long been criticized for being a poor metric for the economy. But it's always been correlated enough with overall economic sentiment that it was Good Enough. It looks like we've finally gotten ourselves into a situation where the edge case issues with GDP surface.

Lastly, not everyone feels recessions the same. I was one of those people who benefited from the financial crisis, because I kept my job and lived in an apartment, so my income was going up while my costs went down. That doesn't take away from the devastation it caused to other people.
I don't know this game but the worst video game in history is Life is Feudal if you take into account how much people have played it and how much it sucks.
"You cannot call Stripe"

Ironic since Stripe requires a phone number to have an account and that phone number is required to be stated on the transaction receipt.
I think your point is a good one. Though I'd say, that's why it's good to describe these as frameworks. They set the rough bounds of expectations, but much like API frameworks, the business logic is specific to your company and its culture.

Anyway - agreed that you cannot just blindly follow one of these. Also, this level of complexity in leveling is something that is best left to bigger organizations. It's almost limiting to impose it on smaller orgs.
The author says, in the introduction, "this entire essay is ridiculous." You are taking it much too seriously. It's all meant in a joking way just to explore some sillier ideas around animal ethics that may or may not have a kernel of value hidden in them.

Nothing about this article is embarrassing, unless you intentionally misconstrue the tone and intentions of the author.
They do small, frequent software updates, it's called minor and patch versions. But when you're making a tool for creative professionals you don't want to release major versions of the tool every year, because these professionals care more for consistency and using their current skillset more than shiny new features in the next version.
I wonder if the author plays Football Manager[1]. The attributes screens use this same visualization.

[1] https://www.passion4fm.com/img/football-manager-player-attri...
In this analogy, political corruption is playing the role of gravity.

Covid could have been prevented by mechanisms that Trump removed. The US inexplicably kept juicing the economy with zero interest rates through the end of Obama and all of Trump. 2008 could have been prevented by depression-era regulations that were removed due to heavy lobbying and traceable payments to (bipartisan) politicians. Whatever bubbles pop next (crypto seems likely to be one of them) will probably have been fueled by that same deregulation.
A toy remote login server
Descriptions of economic conditions are obviously politicized. This was probably always true to an extent, but it really took off during the early Obama years.

That said... my wealth manager has been and still is waffling when I ask him if we are in a recession. It's NOT just political; I don't even know my wealth manager's politics and I have absolutely no doubt he puts fiduciary responsibilities first and makes fact-based assessments.

Unemployment is low and the trend is mostly flat. Housing is doing fine. Consumer balance sheets are strong. Are we entering a recession? I think so. But there are a lot of "but"s which really do impact how smart and impartial people are thinking about where and how to deploy capital.

When I ask my wealth manager "are we in a recession?", he basically says "We might be in a recession. We might not be in a recession. Either way, we should not invest as if this is a typical recession."

Which I think pretty much sums things up.
Quite a few just so stories in here - I mostly disagree with most in favor of my own:

We shed our colors because we lost the emotions expressed by those colors in our lexicon. We don’t put joy, awe, wonder, or whimsy on display. Those emotions aren’t just gone from our palette (walls, furniture, consumer products, cars, fridges), they are non-existent in and of themselves in society at large. Our Art is outrage, performative or otherwise. News is outrage. Media is outrage. Popular culture is outrage. If you aren’t outraged yourself, you are part of the problem (needs more (out)rage).

We will return to playful objects, playful colors and forms when it is once again permissible to express playfulness. We will return to joyous colors that express joy for joy’s sake when we have joy to express… see also the revival of mid-century modern as an implicit revival of the optimism of the 50s.
People can be very irrational in their spending of time vs money, especially if its personal.
If you process more than say $10,000 per year, you should have multiple payment providers.

It's doubtful that Stripe is worse than other payment processors, they just process more payments than most other. Payment processors universally suck, partly because they live in fear of VISA and MasterCard. They tend to overreact or have automated systems that will falsely flag account.

Most have okay support, but resolving issues can take time, especially if the credit card companies are involved. In the meantime, you're kinda screwed.

All the stories you linked share the naive assumption that they could just integrate with Stripe and that's payments sorted.

If you rely on just a single company to handle your payment I assume that what you're doing the a side-hustle and that you have another job that pays the bills. You need multiple payment processors and an easy way to switch between them, that is the sad reality of online payment processing. You may have a preferred processor, typically the cheapest provider, but you always have a backup. That also helps you when your primary processors inevitably have an outage.

You could argue that you have the same issue with using a single cloud provider, but their incentives are a little different. Being too heavy handed could cause customers to leave a given cloud provider, costing the provider money. If Stripe isn't heavy-handed enough, they could lose their integration to VISA, costing them their entire business.
The start of the pandemic reduced gas demand.

The returning to normal(ish) phase - in late 2020, early 2021 - increased it.
DeepMind uncovers structure of 200m proteins in scientific leap forward
> Yet it is still end to end encrypted

I don't see how that's possible. See the instructions at:

https://support.apple.com/guide/icloud/set-up-homekit-secure...

Nothing in the process requires a token/authentication/blessing be done from a pre-existing hub machine that would have to control the encryption. Apple can remotely grant your device HomeKit cloud video based on nothing more than your ability to attest ownership of your new device.

And if they can do that, they can certainly recover the video internally for anyone who wants it. They just choose not to, and you believe them (where you clearly don't for Amazon).
> so I guess my point was right?

No, it was not.

US Tax Dollars Funded Every New Pharmaceutical in the Last Decade:

https://www.ineteconomics.org/perspectives/blog/us-tax-dolla...

How many new drugs rely on government-funded science? All of them:

https://www.cbc.ca/news/health/drugs-government-funded-scien...
It turns out that people are more likely to engage with content they don't like, at least when it comes to factional politics. So that's what ends up being promoted the most.
> isn’t fast enough for anything major.

I think it could be fast enough if portability to different platforms wasn't such a high priority for game studios these days. Nobody wants to write typescript and then pay $50M for someone to port it for Switch or whatever.
The first LotR movie released when I was in grade nine. IIRC, of the 14 students in our class, 11 started reading the books after the movie. Of those, maybe 4 finished. The boredom of Tom Bombadil was the cause of a lot of the dropouts.
> Not sure what part of "it does homology modeling 2x better" you didn't see in my comment? AlphaFold scored something like 85% in CASP in 2020, in CASP 2016, I-TASSER had I think 42%? So it's ~2x as good as I-TASSER which is exactly what I said in my comment.

Wait, stop, I don't know anything about proteins but 84% success is not ~2x better than 42%.

It doesn't really make sense to talk about 2x better in terms of success percentages, but if you want a feel, I would measure 1/error instead (a 99% correct system is 10 times better than a 90% correct system), making AlphaFold around 3.6 times better.
Hacker news is actually non-democratic because people that are down voted and flagged makes content disappear/drop. So the site encourages the small voices to "go away" in favor of the popular opinion.

Or maybe that is what democracy is all about :shrug:
This is pretty nifty and I could see it being quite handy for building one-off pipelines. The whole storing a diff of your change and reapplying it in the pipeline is super clever, though I'd have concerns about how the diff algo would handle different types of source input.

It was only after squinting for a bit and mentally parsing the example code that I had the a-ha moment and understood when/why I'd want to use this though. Maybe a video or asciicinema/terminalizer recording showing how it works in practice might help illustrate
That's why you can use fixed library versions to make sure nothing changes. If you need to update something in the library, you can apply a patch and keep going.
Powerful tool to plan your life and work – a text file
Some people take sleeping tablets to help them get to sleep, although I wouldn’t thought that would be much of a thing these days.
I probably broke hobix with a Ruby upgrade and started a spiral into blog engine madness...
> One thing this phone has going for it is that it is, at its core, an Android phone. There is a chance the device itself may not be unusable after just a few years even if the company disappears. That is not the case for a comparable product like the Purism Librem 5.

PostmarketOS supports the Librem 5: https://wiki.postmarketos.org/wiki/Devices and other Linux Distros have support for the Librem 5. Given how often random Android devices show up and never get supported after they are first released, I would argue the exact opposite. This phone will likely be unsupported after a few years even if the company stays around, whereas the Librem 5 will be supported even if the company goes under.
How would that lead to bankruptcy?
Ask HN: Alternatives to Oreilly Learning?
Now that they have parted ways with ACM, the membership seems costly. What are some good alternatives?
At least in the case of Netflix, they are profitable because the actors contracts are heavily backloaded... and then surprised pikachu face the shows get canceled right before the escalator clauses kick in, typically after the 3rd season.
You can argue that much of the books can be eliminated because they're just not Hollywood, reading is for boomers after all.

The origin of the blade is relevant because they nearly died in getting it, and because it came from the tomb of a prince who himself died battling the Witch King, so in a sense he obtained vengeance from beyond the grave. "Wow, this sword just turned out to be magic, what a coincidence" isn't nearly the same thing.
> is oblivion really the preferable alternative to net suffering?

Well, here's another thought experiment: you are being tortured, very slowly, but kept alive, well fed and sentient. There is nowhere to go. In the end you will be killed, and you know it. You have watched all your siblings be killed, your parents, your children.

You have a button next to you. If you press it, you will die instantly and with no pain. You will be sent into "oblivion", but you will end your suffering.

How long will you resist pressing the button?
Supply and demand, time to start charging people to be featured ;)
> German manufacturing, once a workhorse, is being crushed by energy costs

Hmm, maybe Germany can solve this the same way they "solved" ballooning Berliner rents: just pass a law saying how much energy should cost. Simple. They do love regulations over there.

Or just ask Gerhard Schröder and the rest of their former chancellors who were in bed with Russia, to blow their hot air through the pipes this winter. They have enough of it.