skysight-inc/HackerNews huggingface dataset:
I did as well when I watched every episode earlier this year. I kept on scrutinizing it (and I am normally a hyper-critical TV viewer) but aside from some slight "off-ness" in a few episodes roughly around the time they changed the intro, season after season passed with me still waiting for this decline to occur. Well it never arrived. Did the show change over time? Of course it did I don't know any long-running anything that didn't evolve. I just never noticed it getting less funny, less clever, or less Simpsonesque.

So I brought it up to my brother, who used to watch it with me from its debut until around 2000, and is way more of a Simpsons nut than I am. He explained the decline to me, when it was and what it entailed, from his perspective, which I think more or less vibed with what most fans say. After he explained it, I could kind of sort of see it that way, at least to understand why a person might hold the 'decline opinion'. But I wouldn't have made that judgement on my own.

It still doesn't seem notable enough to me to have turned into "what everyone says". Oh well. More chuckles for me!
Remember that Wikia/Fandom are co-owned by Jimbo Wales. Forcing things off Wikipedia and onto Fandom drives his revenue.
Alternatively, critique threads like this and overall community discussions might eventually lead to a change of policy.

They also might not, but it's both a lot less work than your suggestion, and if succesful would lead to a better overall outcome.
As others have already mentioned, proteins are the machinery of the cell. They perform an immense array of functions and they must fold in a certain way to perform these functions. This is part of what's known as the structure-function relationship.

Misfolded proteins are contributors to numerous pathological conditions and the more we can understand about how and why this folding happens, the better we can treat these conditions.

Another aspect is that while we can at least partially determine the primary structure (the amino acid sequence) of proteins from DNA and RNA, we don't necessarily know their secondary or tertiary structures (3 dimensional conformation). This is a key piece of the puzzle for figuring out how these proteins do their proteiny things and how they interact with other proteins and even how they form quaternary structures with other proteins (an assembly of multiple proteins that perform some function, many pores are assemblies like this). Once we know these structures and understand how they work on a structural and chemical level, we can manipulate them far more easily.

In order to do rational drug design, which is designing a drug for a specific target or active site on a protein, we need to understand these structures. Working to solve protein folding is a key step in treating disease states and understanding how cells work on a fundamental level. The impact is hard to understate.
Yes, exactly. The statement contradicts the author's position that is "exceedingly unlikely" to be a cause of oral cancer. Taken together with the medical consensus that alcohol itself is a considered to be a cause of oral cancer I have to wonder why anyone would be completely surprised by the conclusion that alcoholic mouthwash also increases the risk of cancer.
Similarly, finance people don’t consider interest rates/yields to be derivatives. So, on a bond “duration” is the first derivative of price with respect to yield, and “convexity” is the second derivative.
Ask HN: What should I build on top of Airtable?
I want to spend a few months building an extension/app on Airtable. What’s everyone been missing?
Exactly. The Stripe fans and its nobility will try to keep boosting Stripe's sainthood as if they do no wrong or won't kill your business if you had fraudulent chargebacks (also known as friendly fraud) and will make sure they are only the exception. In reality, you are going to get destroyed by Stripe with such large payments, even if they are not fraudulent.

They actually are killing businesses when they do that and locking their accounts down for months. Even if you have a sum like that for a business or it was an error, well good luck with support as you are not getting that money back and your business will end up shutting down.

That is the dark truth that the Stripe boosters and that the hype squad won't tell you.
No, you're supposed to use the abysmal Discord search feature to find your question among a billion chat messages, or post it in one of the 150 channels we have for each topic under the sun. No sorry, wrong channel. Oops, your message got lost somewhere in the thousands of messages we receive per day.

Discord support is hell on Earth.
Just waiting for someone to apply CLIP guidence onto this (so I don't have to).
Ah, woops. I’d better rewatch it.
Worth mentioning: while traditionally a barometer for a "recessionary environment," it's worth repeating that this isn't a rule. The NBER is responsible for dating recessions and will ultimately decide what to label the 2 contractions + the period after. This is a notable distinction because the first 2 months of COVID was marked as a recession, which did not fall under the condition of "2 consecutive quarters of negative growth."
US Economy Shrinks for a Second Quarter, Raising Recession Odds
KMail: A state-of-the-art email client
Is folding@home obsolete now?
It was alright until you wanted to leave, suddenly you were banned and "no longer represented the community", and wikia employees had wide latitude in doing whatever they could to frustrate any attempt to migrate off of wikia.
What's the OP/your alternative?

Oh Paypal? Look up the horror stories there. Or directly work with a legacy provider like FirstData? They will also freeze your account and won't even accept you if you just have just $3k of sales.

Isn't it interesting that credit card processors really like to give crappy customer support and enjoy freezing accounts? Is it because they just attract misanthropic people? If only a caring company that didn't freeze accounts and gave wonderful support could enter, the field would be better. /s

Actually, the problem is super structural:

- Due to payment processing regulations, there is a fixed overhead from taking a small merchant on. (KYC, AML, ensuring you're not selling drugs). This makes tiny merchants incredibly unprofitable to begin with. Legacy providers like FirstData will reject you outright or make you pay fees to onboard. They will also make you fill out pages of paper forms and put the time cost on you to verify you're a legit business.

We as a society have said the gatekeeping features of finance are more important that making sure tiny businesses have access to payment infrastructure. We should change this parameter if we truly cared about this. I suspect we don't.

- Merchants simply race to the CC provider that is easiest to set up or have lowest fees. If you were OK paying a couple of hundred dollars of setup fees to, you know, properly reimburse your vendor for vetting you, or pay 5% fees for a high risk (read: tiny merchant) specialty account, you probably wouldn't have been frozen like this, at least without them calling you.

This is exactly the problem with Google services. Are you paying Google a bunch of money? If you are a high level enterprise account where the fully-burdened cost of a 1-hour customer support call (~$100) is a small part of your yearly net margin to Google, I bet they would take your call.
https://www.amazon.com/Once-Upon-Atari-history-industry/dp/0...

Would also recommend his book that dives deeper into the mess that Atari was under the leadership of Ray Kassar and Warner Bros.
I think one of the main purposes of sleep is that your mind shuts down and you have no clue what happens during that time.

Anything else and it wouldn’t be sleep.
If someone broke into my house and stole my tv and laptop, I'd be pissed even though I can afford to replace them tomorrow.
Material is mature in the same way that a corpse or old cheese turns "mature". Mature, sure it is, but is it acceptable? I would say it's not.

Sometime after skeumorphic design started dying off, UX has gone in an extremely bad direction. UIs have dropped key affordances and visual cues in favour of oversimplified design elements. UI/UX designers started to optimise for juicing the maximum amount of money and attention out of users too - the focus on "calls to action" and notifications is one example. Features that are 10x force multipliers for users when used sparingly in designs, have been overused to the extent that they become cognitive burdens. Apps are getting redesigned on a whim, confusing users who cannot adjust.

UX designers are having fun with the new landscape, but users are not. It's time this is recognised, and designers start to pull more pages from Apple's design handbook, and not Google's.
Just as a counter-anecdote, my one-person SAAS has used Stripe since 2017 and I’ve had an excellent experience with them, including personal customer support. Of course, YMMV.
I honestly don't even know if it's "you might steal it"

It's just this vague notion of "if you aren't contributing to this repo you don't need to access it" or something.
Yup, how many times have we seen it here on HN alone where someone has posted “Google nuked us from the Play store and won’t talk to us about it” only to be returned after the post hit the front page?

People shouldn’t have to go viral on social media to get decent customer service just because “computer says no.”
A Foundation Course in Reading German (2014)
That's very odd. It really looks as though this used be be available and now isn't.
It'll be interesting which of these win; scanning real life objects as you describe or just generating 3d assets directly through a DALL-E style model.
Pretty sure Nigerian Princes are sending those emails a few times per day
Some are meant to be noticed: mandated calorie counts on food menus (nudge to health eating), or dire warnings on cigarette packs (nudge to quit smoking). Neither of these have had any measurable impact on their goals; I welcome evidence to the contrary.
I also add turmeric and cinnamon. There's always a bit of sludge at the bottom.

I use coconut cream, instead of bulletproof-style coconut oil, because I need my morning coffee to be somewhat palatable.
A single instance of holding 3k doesn't seem like (or shouldn't be) a significant amount for a small business.
> What users' need are they trying to address or create?

They're essentially trying to _create_ a new need in the minds of consumers, I think.

The trouble for them is, this rarely works. This is quite different to, say, the iPhone; when the iPhone showed up, the market was already inclined to think "it would be nice if there was a good phone that could do more stuff than my Nokia"; it wasn't specifically demanding an iPhone, but an iPhone was a good solution for what it was demanding. It's not clear that anyone is demanding a 'metaverse'.
Moist widely elicits this reaction because by the inviolable rules of English grammar, it can only ever modify two things. Cake, and vaginas.

And towelette. Three things. But no more.
Railfan
FWIW it's totally possible to talk to someone at Stripe. We got someone on the line and successfully negotiated their fees.

We're now using a 2nd payment processor that handles a type of payment unavailable at Stripe and they're just garbage compared to Stripe's backend / control panel system, which is phenomenally.

Excellent company as far as I'm concerned.
It does depend on where you live. In southern europe red or orange clay roofing and a range of colors on traditional housing including yellow, pink, orange, etc. makes towns appear much more colorful. In parts of Portugal it's also traditional to paint a broad colorful bar along the bottom of whitewashed outer walls and around doors and windows; the color changes from place to place, and it can be black (I've seen that in the Azores) but also blue, green, scarlet, etc.
And Safari on MacOS
How GNU Guile is 10x better (2021)
Parts of the ruling:

"It may be noted that here the parties themselves made no reference to secrecy in either the 1881 or the 1885 agreements. The word "secret" is not used anywhere in either of them. It is true that I have assumed during this discussion that the plaintiff is correct in its contention that what Lambert bargained for was a "secret" formula. But that in *666 no way justifies the further assumption that he also bargained for continuing secrecy or that there would be failure of consideration if secrecy did not continue."

"Thus, I hold that under the agreements in suit plaintiff is obligated to make the periodic payments called for by them as long as it continues to manufacture and sell the preparation described in them as Listerine."

The judge recognized that it was not just the mere formula, but rather the brand name, that supports the value of the product and thus royalty agreement.

It's in J&J's best interest to sell under the brand name, which is the #1 in the world, and simply pay the royalties.

https://law.justia.com/cases/federal/district-courts/FSupp/1...
Mainly harassing women. But maybe that isn't such a big deal to some. If it is, you can read about it here.

https://rms-open-letter.github.io/appendix
I almost always wear hi-vis orange shirts, and my preferred hoodie is hi-vis yellow (pity it’s not orange, but that’s the one I’ve got and I don’t need another). Good quality, readily available, comfortable, cheap, and I stand out and am memorable in most contexts, which can be useful. Probably blinds people a little in direct sunlight, though no one’s ever mentioned such a thing. Occasionally throws people for a loop because they assume I must be some kind of tradie.

I started this back in 2010 as a safety measure when cycling from home to Uni, and rapidly decided I liked it.

I’ve progressively branded myself more and more in bright orange. Funny thing is it isn’t even close to my favourite colour.

My car is “velocity red”. Pity it’s not metallic orange or green or some other more interesting colour, but I certainly don’t care enough to foot the bill to repaint it.
You can see the parallel thread about R+D and if that makes it unaffordable:

Amortized, the answer seems to be that trucks would remain affordable — even at the $100B to $1T cost to develop.

> It just tells you whether some finger-in-the-air numbers you selected sum to >0.

Estimating the unit economics and R+D amortized cost (as I did) is more reliable than going based purely on your feelings — as you have done.

I’d appreciate if you would make specific criticisms about my model, rather than tell me how you feel about the topic.
But this isn't theft? The funds are being held, they are likely to be returned _at some point_. Inconvenient, sure. But theft?
It's a warning that it's not an Apple-approved device

It may (or may not) be "shady"

It's an especially helpful message when plugging into a not-before-seen computer

It's also helpful as a warning that you may not have as high a QC standard for the charging device as you should for your $1000 pocket supercomputer we call a smartphone
It's not quoting, it's paraphrasing. The comment was very suggestive in that homosexuality is bad. If that was not what you meant, you might have chosen less suggestive text.
We know the structure of some proteins. It's not that it's impossible to measure, it's just very expensive. This is why having a model that can "predict" it is so useful.
For cars specifically, I have a theory it may be explained by a lot of people go for resale value. Feels more likely to find someone to buy a gray car than a bright green one.
> Why do you feel this is relevant, let alone detrimental to the idea of microservices? It looks to me that it's one of the primary positive traits.

I did explain at the end of the sentence, why it was relevant: because rewriting in JS would have also meant switching to a completely new language. Which the team, as a whole had less experience with and which would have made it a complete rewrite without being able to reuse anything.

> This statement makes no sense at all.

I'm sorry you didn't understand it. If you asked a clarifying question I may have been able to explain.

> You stated the legacy codebase was crap,

No, I said one team member stated that the code base was crap. I didn't say it was crap. I didn't evaluate it, because I don't know (and don't like) PHP and because I didn't have to work with it anyway. The other two team members said the code was of acceptable quality for them to work on.

> and that a team member took up to himself to do the strangler's vine thing and gradually peel responsibilities out of the monolith. What leads you to believe this is stupid?

Because this is not what was going to happen and because they had been working on the thing for about 2 years back then without releasing it and because their planned release would have been in about 2 months. It's almost never about only the technology, these products and services serve a business purpose or provide value through other means. If it didn't matter, you can of course take all the time in the world, start over 10 times just to come up with what you think the best solution is for the problem. It's totally fine, this is the artistic approach. If you follow the engineering approach then you have to factor in the time and the investment too. Because in that case you have to deliver value.

Regarding peeling away gradually, this wasn't really what I said. The person pushing for the microservices solution said they needed to rewrite. So stop the world, rebuild the thing without having a working system during that period. (Because they didn't have a working system to start with.)
Had a similar issue during lockdown where we had more orders than usual. Stripe kept the money for 3 months. Contacting them for support is a non-existent (robot replies). Hope a competitor is taking notes to all this.
Indeed. And with their recent healthcare acquisition, they aim to be your primary care physician, too! They already spy on you with Ring and Alexa. You're in such good hands with Amazon.
Seems like a stretch that using screens has led to a decline in interior decorating. You could argue a whole generation including men are now devolved into desk setups, plants, terrariums, "earthy colors", hygge, woodworking, aesthetics, etc through Pinterest, Instagram, etc. The same revolution has happened for the glorification of cooks -> chefs and the proliferation of home bakers
I'm still laughing my ass off that the support letter got more signatures.

https://rms-support-letter.github.io/

You and other US people are not representative of FOSS.
> the need to drop into a terminal to debug certain things, and the difficulty of dealing with driver problems for inexperienced users

Have you used Windows recently? At least the former is a growing problem. Dropping down into the registry to change or create keys is no cakewalk either. If you're an inexperienced user, you're in trouble on Linux and Windows both.
If you're self employed and your monthly income is 5k$ from your business, 3k is a lot and can mean that you're unable to pay bills or food for this month.
The article mentions that he had been using the Sleeper train for 15 years, so I imagine he's used to it.
Given the choice, I'd still much rather live under the jurisdiction of the U.S. than Russia. The U.S. is far from perfect, but I'll choose her over Russia, China, North Korea, Cuba, etc. any day.
Honestly just never explored it much, but my whole family and friend circle is on Facebook Messenger. Does this work through Matrix in some way?
I had a mental model of trucks going from waiting lot to waiting lot on the freeway, and going the last couple miles either by switching cabs or having local drivers take over.

I think you reduce a lot of the challenge with freeway-only driving between large staging lots adjacent to industrial areas and allowing humans to do the “hard” part of the first + final mile.
Have you compared the backends you get to use as a customer? I'd be surprised if Adyen even comes close to Stripe.

Mollie for one is complete garbage.
TL/DR; How can current ML predict anything outside its learning domain? Am I misunderstanding the fundamentals? In which case, I do not see this headline as ground breaking (apart from real benefits of speed, exploration possibilities, ... that is why we make models to begin with).

The advantage of ML (as far as I can use it) is its speed, and ease of applicability once trained. The training dataset is well prepared, and the pattern recognition (abstraction of the) problem from the data is well-posed(?)
Note, I didn't say all animations, I said page transition. Don't animate a page transition.
Gawker deserved someone to come after then as Thiel did, for what they did to him, Hulk Hogan and others
It should be noted that a significant difference between Steven Danziger and Erin Brokovich is that he took on a US energy corporation which was acting against non-US citizens.

The US state apparatus clearly considers that US corporate economic interests far outweigh any rights non-US citizens have, especially outside the USA, and doubly especially in South America, and are thus more than willing to provide any kind of assistance that helps those economic interests - up to and including military aid in the past (for example, the infamous banana republics).

Taking on a US corporation harming people outside the USA (especially if you have the gall of winning!) is seen as a slight on the USA itself, and is punished as much as possible. It's important to the US state department that people are taught not to take such a task on lightly. I'm surprised there weren't bigger repercussions for the foreign judges who tried the case as well.
> the amount of bookkeeping

Any example?
Oh! It seems this has been the case for at least 6 years: https://lwn.net/Articles/686904/
We're not talking about raises, we're talking about one-time performance bonuses.
This is an accurate description of the different ways it sucks when one insists on using software on unsupported or semi-supported hardware.

Of course there will be unsupported wifi cards on the market. Of course there will be cards which kind of work when you load some unsuported third party driver but they will promptly crash on some future version. Those will never be supported in upstream software. Don't buy them and force Linux on them, it won't end well.

Don't buy a Dell PC and be angry at Apple when MacOS won't run. Unless you do it with the intention of working on a port. It's the same situation with any other operating system.

It's also been pretty clear for over a decade that nvidia is unlikely to be supported in upstream software, as long as they won't use the same standards as everyone else. There's been some recent developments on that front which suggests this situation may not be forever, but don't hold your breath.

Given the choice, it's pretty common to use Linux, at least among developers. One of the great things about it is that it just works. I have now thrown away the hardware but I used to have a workstation with a Debian install that was about two decades old. It had only been upgraded in-place, never reinstalled, and how many libc upgrades that included I do not know. The migration to the new executable format in the 90s was a bit problematic in the beginning, but that worked out well too. That's the sort of stability you can expect from it.

It was a long time ago I bought any new computers, but in the laptop realm well supported for a long time meant the performance Thinkpad series. Now all the big providers sell laptops with Linux pre-installed, so I take it they will work great too. But there are a lot of crappy Windows-type laptops out there. They're the kind that turn themselves on in your bag and cooks themselves. The Linux experience aren't going to be great with them.
One way to get a response, and a better than 120 days response, from Stripe is to file a complaint with the attorneys general offices of your state and the state that Stripe is incorporated in.