skysight-inc/HackerNews huggingface dataset:
All of the loops and swirls are summary representations of known atomic positions: really, knowing a protein structure means knowing the position of every atomic nucleus, relative to the nuclei, down to some small resolution, and assuming a low temperature.

The atoms do wiggle around a bit at room temperature (and even more at body temperature), which means that simulating them usefully typically requires sampling from a probability distribution defined by the protein structure and some prior knowledge about how atoms move (often a potential energy surface fitted to match quantum mechanics).

There are many applications of these simulations. One of the most important is drug design: knowing the structure of the protein, you can zoom in on a binding pocket and design a set of drug molecules which might disable it. Within the computer simulation, you can mutate a known molecule into each of your test molecules and measure the change in binding affinity, which tells you pretty accurately which ones will work. Each of these simulations requires tens of millions of samples from the atomic probability distribution, which typically takes a few hours on a GPU given a good molecular dynamics program.
Yes. Server-side with good old-fashion log analyzer.
I use Dash on my Mac for most of the documentation. It makes searching any of the "docsets" it has indexed fast. I've recently started creating some of my own.

I save references I use a lot, like the HTML spec, as PDFs. MacOS indexes these PDF files, so a search in Finder is usually all I need to bring the correct document.

If I can't find a reference locally, or know it doesn't exist locally, I'll turn to the Internet. Once I find the bit of information I'm looking for I'll either save the website as a PDF, or save the info in Snippetlabs or Bear so I can search for it next time I need it.
What's your point? "No country is perfect, so we can ignore even the grossest misconduct by the United States"?
Which is largely irrelevant.
Latex and associated templates/libraries/extentions can be examined for publication quality examples of tests.
To a computer scientist "programming" is simply a means to an end. Computer science is a rich field. Equating programming to computer science has been the greatest fraud ever perpetrated on the field, and in my opinion why so many people flunk out of the program. When I was in school the first and second semester were filled with people who wanted to be programmers (for the money) and got blown out by the operating systems course. I can probably count the times on one hand where I did any programming in my undergrad. Most of it was in graduate school to verify algorithms.
If inflation stays around 9%, you can expect many companies to post record profits every quarter in dollar terms.

Companies with heavy capital investment will see huge gains in % profit as their debt obligations are inflated away.
A lot more products are now built by machines, therefore saving on something like buying more different paint or less time "wasted" to reconfigure the production line makes sense from a business point of view. Thankfully, the real world (sun, mountains, lakes, my shirts) is still colorful as before.
Congrats. We're big fans of Retool! We're a neobank and use Retool for all of our internal customer service, operations and compliance apps.

Our subscription is now up for renewal and it looks like we're in for a big price increase as we transition from a handful of shared users to 50+ named users + granular permissions. We're still a very small startup (<5 developers but lots of external customer service people using Retool) so hopefully we can find a way to take the company size (and not just the number of seats) into account.

Looking forward to continuing to build on Retool!
I work with C# and I almost never use stackoverflow anymore. Back in 2013 when I started working with it I remember I would use stackoverflow every day. But now I find way more answers in github issues. The answers on stackoverflow are usually really dated if they exist at all. Its almost like when microsoft made the move to dotnetcore and started hosting the project on github all the dotnet related activity on stackoverflow stopped.
I've been looking for a replacement for that font for a long time. Do you have any suggestions?
Which I interpret to mean that Zuck was acting here. Do we think that they present unreviewed questions to the boss in front of the company?

This was for show.
> Tom is entirely beyond caring about "good" or "evil". His peace is such a vital contrast to every other character and has stuck with me over time.

Yeah, exactly this. To me, Tom is a part of nature, even moreso than the elves or the ents, which isn't really good or evil. That's another reason I didn't like this post at all. Tom isn't some malicious force, biding his time until Sauron leaves when he can dance upon the corpses of the Hobbits. He's a mystery, a hint at the depth of the world, and a curious aspect of nature.
it's called respect, fellow hacker news reader.
Show HN: Feathery – build powerful, developer-friendly forms
Standing Out – What makes a programming language successful – Jeremy Howard
The origin story is still under debate? It's been known for 2 years that the Pangolin coronavirus was modified.
Just under 97% of the the Pangolin Coronavirus matches SARS-CoV-2.
What does not match? The Furin Cleavage Site. There are foreign inserts there (that aren't found in any other Coronavirus) which seem to make it more transmissible and deadly.

MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site
https://www.frontiersin.org/articles/10.3389/fviro.2022.8348...

The study is a bit technical but a not-as-techincal summary can be found here
https://nakedemperor.substack.com/p/lab-leak-theory-new-arti...

To summarize, a gene sequence from the Furin Cleavage Site found in SARS-CoV-2 shows up in a Moderna patent from 2016.

Don't take my word for it though, research it for yourself.
Any opportunities for hyperskilled labor, preferably online and pseudonymously?
Not an adult, worsening home situation - which wasn't great in the first place, so could really do with quick money. Assume skill/competence is not a barrier.

The best method know of is ImmuneFi's bug bounties: https://immunefi.com/explore

Anyone who has the skills necessary to find a vuln can instantly convert them into money, without any barriers like formal credentials or onboarding processes (for which I have no time).

What other opportunities (in any sector, not necessarily CS-related) share the same characteristics?
Well thought out. After reading the article I was thinking that its going to take some significant changes in something, I was going to say western priorities, but I don't even know what to call it, to extract ourselves from the mess we are creating for future generations... When we can allow corporations to have the power to poison the planet with little recourse I have a hard time seeing the light at the end of the tunnel.
I agree that the runtime-validador-with-type-inference library genre is generally enough for API surface area. We have a similar internal library, including JSON schema output, and it’s serviceable for checking our public & private API incoming requests.

It does come with some costs. First, the type inference using these large mapped types (at least in our implementation and/or scale) noticeably slows down our Typescript type checking; the public api files with our runtime type declarations always top our build profiling. Second, it’s annoying to need to re-implement an existing type as a runtime-type if you start to need it in an API specification. There’s a tension in the codebase between using the easily-available, language native type system, or making do with the runtime type stuff which increases verbosity/noise and decreases expressiveness.

We have thousands of lines of types, including many types inferred from `as const` literals, written in Typescript. Rewriting those types in another schema language, such as typebox or Protobuf, would take a bunch of time and spread that tension from an isolated spot (backend API handlers) into every part of the codebase. It imposes new constraints, and requires devs to learn more things.

The libraries I listed and the compiler I’m building try to address this issue by supporting the native typescript declaration syntax. No more red types and blue types, much better gradual adoption pathway, and ideally one less thingy to learn for most developers.
This reads and feels like an onion article
Hey HN – I'm Peter, Founder & CEO of Feathery.

One year ago I was working as a growth engineer at Robinhood, where my team needed a better way to build and improve complex forms for use cases like signup, onboarding, and applications.

Last week, we opened up public access to Feathery, a low-code platform enabling product teams to build powerful, developer-friendly forms. It’s complete with a Webflow-like visual editor, a flow builder that supports advanced conditional logic, powerful integrations like Plaid and Firebase, and open-source embed libraries with extensible APIs.

If you’re part of a product team or startup looking to build better forms, you can get started with Feathery right now for free. I’d love for you to take a look at the platform, share questions and feedback, and I’ll answer those here today.
I mean I hear you on "changing the definition" from the commonly accepted two quarters of declining GDP numbers- though that was never actually official, you are mistaken about that- the NBER is the "official" source and they declare it based on a range of factors that there is some subjectiveness to- its not a direct formula.

However, wouldn't you agree there is nuance here?
In Q4, GDP rose 6.9%, a number so big that we haven't seen that in decades- it appears around the early 1980s was the last time we saw those kinds of numbers. There has been a lot of whipsaw effects as we get out of covid- supply chains are all over the place, companies placing orders to get goods in to avoid snarls, only to now find that demand for goods, which boomed during the pandemic, has now eased as people have reverted to spending on going out and traveling, etc... There seems to be a lot of mismatch in supply and demand again.

The unemployment rate is at 3.6%- an astonishingly low number- these lows were last seen in the 1960s and 1970s.

On the flipside, inflation is high, gas prices are high and that hurts a lot of people- I live in a city, so this is mostly irrelevant and driven by forces out of anyone in the US govt's control.

There is evidence of some rockier times ahead, but when I think "recession" I think of a lot more pain than what we are currently experiencing.
I remember when Palin ran for Vice President she had a day of interviews for local media types from various parts of the country. She did a number of consecutive interviews and in one made a dumb mistake conflating North Korea with South Korea. She was ridiculed by people for not knowing the difference. Now, I believe Palin is profoundly dumb and ignorant but she didn’t deserve to be attacked for making a mistake during a full day of interviews.

You mention one statement from the Press Secretary ascribe to it malice. Do you know she lied rather than was misinformed? Assume she is lying. Does this mean the whole administration lied? The discussion at hand is about Yellen (and by extension economists at NBER and other agencies). One statement by the Press Secretary is evidence of a lie by these people? I don’t think so.

It’s believable that Yellen and Biden and Pskai did lie because in politics you try to sway public perception and opinion. I don’t believe NBER has lied and to blame inflation on fiscal stimulus that largely occurred two years ago seems outright bad thinking. Especially to then blame the current administration for it. Inflation is going on all over the world. It’s not Biden’s fault. There’s a collection of reasons and mechanisms at play and Biden can only do so much.
That's quite flippant. They are a big investment, no question, but they open up a lot of possibilities since you can essentially go anywhere at any time with a large capacity in case you need to take things with you. They can help you to physically reach employers who could pay enough to make the vehicle a small cost, depending on the situation
As a third worlder in a considerably corrupt and iniquitous society, it was all about avoiding either a dead-end quasi starvation little impactful job, or morally questionable work. The realization itself was essentially religious to me, God guided me towards this decision when I was 16. At 29 it was well worth it, I have my own international business while still living where I was born and being a force for good.
Barrow-wights are Bombadil's servants? Ridiculous. Tolkien made it clear that they were the spawn of the Witch King, sent out to ensure that no men could settle in that particular area. This is reinforced by the fact that Bombadil himself destroys one of the wights while rescuing the hobbits.
First thought on my mind too.

Is it just me or do a lot of famous software people meet their end by cancer?

It reminds me of something from a bit of mystic literature. It was offered that serious practicioners of "concentration meditation" tend to get the crab.

And software developers are nothing if not concentrated.

Makes you think.

What is this "attention" thing anyway? A field? A ray? A wishing machine?
Unfortunately, all of the text spam I get is of the scammy misrepresentation variety, and is going to fail on the "identify the other party" step.

Edit: for instance https://imgur.com/D780jAX -- after I naïvely responded to the first few like this and got their pivot, I started to recognize the style.
Tangentially related, the BBC published a pretty solid radio adaptation of LOTR in the 80's:

https://archive.org/details/the-lord-of-the-rings-bbc-radio-...

(no sign of Tom Bombadil here either though, IIRC)
As a child I was always doing crafts and loved playing with electronic circuit toys and lego robots and such. With 12 y.o. on school we were taught LOGO (that programming language with a turtle) which allowed me to do anything I wanted as fast as my mind went, without physical limitations and without needing to buy material nor tools.

I've been programming since, I can't stop.
>>Is it theft if I pay my bills late?

Depending on how late you pay them, YES, it is theft, and can be so judged in court.

>>. Have you ever had a customer fail to pay an invoice on time? Have you ever not been reimbursed for expenses in a timely manner? Have you ever been charged the wrong amount? Had a supplier go bankrupt?

Yes, all of those things. And I pointed out that SOMETIMES, they can go by almost unnoticed and dealt with in due course, but OFTEN they can create real problems. It is one thing when they happen by accident, but when it is the result of capricious and hostile decisions by a vendor, it is an outrage.

Your own argument points this out - if $3K is supposed to be so manageable to a small biz, then it is not even a daily rounding error for Stripe, and THEY should give him the benefit of the doubt, and not externalize these costs onto the small biz.

I'd also point out that just the fact that you're justifying paying your bills late as "well it isn't theft" already tells me that you are in the class of ethically-challenged shady operators with whom I work to avoid.

Just because you make a profit does not mean that you are running a sound or ethical business or personally have either of those properties. I'd suggest you do some rethinking.
That's like if a professional writer didn't know how many letters are in the alphabet.

It has no bearing on actually doing the job, but how on earth did you manage to learn the necessary skills without learning that?
I had the same reaction. Not much explaining, no justification for the tooling decisions, pushing more undocumented code to pypi because why not, "I saw this other package do this", etc.

I guess it's great if you're just looking for a shortcut to push something up to pypi, but my guess is someone new to it won't really understand what's going on other than some vague sense that they're following "best practices".

And then I imagine that same person will go on to write another article like this, and on and on we go!
No, sorry, this is wrong.

9-11 works because the tragedy was 'massive' (the biggest attack since pearl harbour and most civilian deaths ever).

Any name applied to 9-11 would have 'stuck'.

Moreover, 9-11 caught on at least in part because 911 is 'emergency' number in North America.

Hurricane Katrina comes nowhere near that threshold. Now - it may have been giving a populist name, such as 'The Orleans Breach' or something instead of an official name.

But the names really do help us remember and contextualize.
I'd rather shave a year or two off my life than deal with a lifetime of getting my shit stolen... and living under the constant fear of violent assault, or the pain of watching females in my life living under the constant and real threat of sexual assault.
An app in express.js, a web framework.
The punchline is a link in the last tweet of the thread: a non-affiliate link to OP’s acquaintance’s kit to file a lawsuit of your own. [0]

[0] https://www.isipp.com/how-to-make-phone-and-sms-spammers-pay...
For both your and your parent's counter responses, I have to agree with MichaelCollins: Most people are still better served with the irrational response.

In fact, until the other party can justify my using my time to engage with him, the irrational response is a good one.
>> Would you say AM/FM radio waves exist only in our mind?

You're tweaking the analogy.

I didn't wrote 'electromagnetic waves exist only in our mind'.
I wrote the qualia 'color' exists in the mind as the highly processed result of the activity of certain complicated structures in space-time.
Some carriers of these structures, that is some humans that are convinced the idea of science is reasonable, like to call these structures brains.
So a lot of people on this planet, but by far not all.
Others call them 'soul' or whatever is the currently most useful and hardest to disprove in their environment.

The electromagnetic waves that trigger certain sensors in the eyes and trigger that processing are outside those brains.
Or at least those brains assume they are.
Assume with more or less good reason.
But to complicate the thought, that is an assumption.
That is, an element of the mind.

But anyone in their right mind should back away from the abyss of solipsism now, right?

>>Our eyes are sensitive enough to detect differences in the wavelengths
So you are not seeing colors, but differences in wave lengths?
That maybe, but most of us do see 'colors', that is a subjective perception?
Do you see a red rose or a '620 to 750 nm' rose?

Sorry, but I just love to ask people, what is 'red'?
Just describe it, can't be that hard.
Godot 4.0 development enters feature freeze ahead of the first beta
GFP-GAN Can Fix Most Old Photos Instantly
Depends: in many places the high-vis hits the “I'm wearing this because the rules say I have to and I'm not important enough to flout them even though they clearly don't matter here” note very well.
East Palo Alto has shotspotter installed throughout. In summer of 2020 there were several weeks of nightly nearly non stop fireworks. Shotspotter should have been able to help the police pinpoint the locations of these illegal fireworks yet no enforcement actually happened.

Now part of that might be because of the defacto police strike in response to "defund the police", but the noise went on long enough and was heard in nearby wealthy cities enough that actually motivated police forces were pushing to fix the problem and yet shotspotter proved useless.

This leads to the allegation that shotspotter doesn't actually work at all and is just there so when a hothead young cop does something wrong without thinking the police department can, after the fact, get shotspotter to gin up some probable cause.
You earn millions of dollars for essentially keeping the trains running on time by instructing your minions to keep the trains on time, and then the market says we need new tracks and new trains and everyone's getting off your trains.

You'd be grumpy too, when the minions look at you and ask for a spec and a strategy and you realize your going to have to do work for the first time ever.

Consider MSFT, not the biggest fan but, they make stuff and can change and improve your life with it. They have a revenue of ~200bn, Meta is ~80bn, but what do they actually make?

It's not a totally worthless company but it's been trading on the fact it got to be the first decent social graph company for the last two decades.
In college I got to the "weed out" course for sophomores and juniors. Operating systems. Most people floundered and I did exceedingly well in it. I became obsessed with different kinds of operating systems and how they were built. In particular, multi-core/parallel (which was a big thing back then) and real time operating systems. My professor invited me to the graduate parallel programming class as an undergrad and I had a GREAT time.

Then I got into compilers, the weed out course for seniors, and enjoyed it as well. All of the different optimizations, algorithms, clever things that can be deployed to make things fast and efficient. I ended up taking a graduate numerical analysis course as well which was math with a "computer science" flavor to it. It meshed very well with my brain and I loved learning about all the different speed up procedures and ways we can make computers do math by cleverly manipulating functions.

I was always interested in computer science adjacent things because growing up I was always using second hand computers, and so I had to come up with ways to make things fast on slow hardware. Once I got into school it solidified my love for the field itself. My only regret is I wasn't able to finish graduate school because I was paying out of pocket and working a 40 hour a week job.
Shelob is not a primordial being. She is one of the children of Ungoliant, who is herself a fallen Ainur.
The Java Runtime is pretty ubiquitous, so maybe compiling to Java bytecode would be a better approach for a "universal" executable, if runtimes are allowed.
Oh yeah. Walking around a manufacturing plant. Brand-new hi-viz vest over a dress shirt, walk purposefully. "Must be management."

I wasn't management, I was just new on site and had come from a planning meeting, and I was pretty sure the next guy I needed to meet was in the belly of the plant in a location I only had the vaguest idea of, but I knew it was gonna be a long walk.

I ended up walking the length of the place twice (almost a mile) before I decided I'd had enough sightseeing (but what sightseeing it was!) and and actually asked someone, who made a wisecrack about how he helps so many visiting managers in this joint they should make him a manager himself! I decided against correcting him.

Over the coming weeks at that plant, I wore a T-shirt and older hi-viz if I wanted to blend in as a worker, or a button-down shirt and the crisp hi-viz if I wanted to wander. As long as I kept abreast of my assigned duties, nobody sweated the details, and it was better than any museum of science and industry I've ever paid to get into. Had a few more folks make gentle cracks about how I must be a manager of some other group over to see what this group does, I'd ask a few questions and be on my way.

Likewise for jobsites and urbex, I have a hard-hat covered in stickers, and one that's so pristine I keep it in a pillowcase. Perceived wear is an important component of The Look™.
Interesting! I hadn't considered that. :)