skysight-inc/HackerNews huggingface dataset:
The most amazing part is that this is FDA approved but there was been no efficacy nor safety studies conducted with the exact Bonjesta formulation that is being discussed here:

> Commentary: There have been no efficacy and safety trials conducted with Bonjesta. A double-blind, randomized, multicenter, placebo-controlled study was conducted to support the safety and efficacy of 10-mg doxylamine succinate and 10-mg pyridoxine hydrochloride tablets (a different formulation and dosage strength) in the treatment of nausea and vomiting during pregnancy. Women 18 years of age or older at seven to 14 weeks gestation (median, nine weeks) with nausea and vomiting were randomized to 14 days of 10-mg doxylamine succinate and 10-mg pyridoxine hydrochloride tablets or placebo. The primary efficacy endpoint was the change from baseline at day 15 in the Pregnancy Unique-Quantification of Emesis (PUQE) score. The PUQE score incorporates the number of daily vomiting episodes, number of daily heaves, and length of daily nausea in hours for an overall score of symptoms rated from 3 (no symptoms) to 15 (most severe). At baseline, the mean PUQE score was 9.0 in the 10-mg doxylamine succinate and 10-mg pyridoxine hydrochloride tablets arm and 8.8 in the placebo arm. There was a 0.7-point mean decrease in nausea and vomiting symptoms from baseline in PUQE score at day 15 with 10-mg doxylamine succinate and 10-mg pyridoxine hydrochloride tablets (95% confidence interval, 0.2–1.2; P = 0.006) compared with placebo.

according to this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215271/

Maybe the manufacturer has realized this and is apparently now conducting an actual clinical trial, focusing on adolescents, probably for an expansion of its indication:

"A Multicenter Trial of the Efficacy and Safety of Bonjesta® for Nausea and Vomiting of Pregnancy in Pregnant Adolescents"

https://clinicaltrials.gov/ct2/show/NCT05289557

the FDA is a running joke at this stage. Why would anyone trust that agency is beyond me.
It's technically not triangulation, it's multilateration

https://en.wikipedia.org/wiki/Multilateration
Awesome project. Keep it up, guys!
I moved away from Firefox when Mozilla went "woke". What's the point of supporting an organisation distancing itself from its core ideals and laying off employees while the CEO gives herself a "raise"? I felt terrible for the people being laid off in the pandemic and the impact on their families. It's good to see Firefox haemorrhaging a slow uneventful death.
What complexity do you feel is unneeded?
The Bobbit Worm Chronicles
> I think a more charitable explanation is they listened to a loud minority, one I would have been part of.

Having seen this type of thing play out in several industries including other open source projects, it would have been more like follow the competition I would say.

Users sometimes get listened to. Often times that's only to retroactively justify decisions that already got made.

What gets attention is competition. Incumbents are watched like hawks by everyone for obvious reasons. And the incumbents themselves are paranoid of newcomers or new ideas.

I worked in software at a company that developed CPUs. "Intel is doing this" or "Intel is adding that instruction" was the quickest and easiest way to get the attention of CPU designers. Not "our customers want this" or "that instruction will speed up this software our customers run". Those things would be considered, but you would have to do a lot of work, modelling, and justification before they'd look at it.

There's actually good reasons for this. Intel having done something, you could assume they had already done that justification work. Them deploying it meant customers would become familiar with it and accept using it (or even expect to be able to use it). So it's not necessarily stupid or lazy to put a lot of weight on what competition is doing, it can be very efficient.

You can get into these death spirals of the blind leading the blind when everybody starts fixating on something if you're not careful, though. I'd say this is what happened with everybody trying to shoehorn smartphone UIs into the desktop back then.
Ask HN: How did you learn to do the thing that you know how to do
This is really nicely written; kudos to the author for compiling a great deal of information in a readable format.

If I can be forgiven one nitpick: Poetry does not use a PEP 518-style[1] build configuration by default, which means that its use of `pyproject.toml` is slightly out of pace with the rest of the Python packaging ecosystem. That isn't to say that it isn't excellent, because it is! But you the standards have come a long way, and you can now use `pyproject.toml` with any build backend as long as you use the standard metadata.

By way of example, here's a project that's completely PEP 517 and PEP 518 compatible without needing a setup.py or setup.cfg[2]. Everything goes through pyproject.toml.

[1]: https://peps.python.org/pep-0518/

[2]: https://github.com/trailofbits/pip-audit/blob/main/pyproject...
But you probably are going to be running this as JS eventually
> This man knew we were heading towards an uninhabitable world [...]

Huh? Since when are we heading towards an uninhabitable world?

Yes, climate change is real. But it's not going to make the world uninhabitable.

The best estimates are that climate change would cut between 5-20% of global GDP. See eg https://en.wikipedia.org/wiki/Economic_impacts_of_climate_ch... or https://www.nytimes.com/2021/04/22/climate/climate-change-ec... (Keep in mind that the latter is an article from the NYT reporting on an analysis by an insurer. The NYT isn't exactly a climate change denier.)

That's a gigantic number in absolute terms. But it's also less than the difference between US and UK GDP per capita. And the UK is far from uninhabitable.

(My assumption here is that an uninhabitable place would have essentially zero GDP. Therefore to retain 80%+ of GDP, the planet must still be heavily inhabited.)
As a simple example, one can look at f(x)=1/x in R+. The derivative is f'(x)=-1/x^2 and the second derivative is f''(x)=2/x^3. In general, every function of the form f(x)=1/x^n with odd n will have this behaviour, and if n is even the behaviour is the opposite. And yes, many more examples can be found.

More generally, this is why I'm wary of indirect indicators. They never tell the whole story, and because of that they're used disingenuously in order to muddy the waters. You see this a lot in big scale PR campaings, such as climate change denialism, and pro-sugar and pro-alcohol disinformation (we had a lot of pro-tobacco as well, but it has subsided in the last two decades or so, at least in the West).
It certainly does look like a DEC product of some kind. The case isn't wide enough on the right and the badge is in the wrong place fora VT100, so I wonder if it was another DEC model, or an unrelated product with some copied styling cues.
Being at FB is a cancer on my resume. I have removed it.
Agree with some of your points but you are missing something essential here.

You don't pay for the cost of the ingredients in pharmaceutical products (otherwise the cost of most drugs would be 1/10th of what they are or even less), but for the IP behind it. You need clinical trials to demonstrate that something works for a specific condition, and this is what gets an approved stamp by the FDA and integration with the reimbursement system, along with a negotiation on pricing.

If there were no such incentives, then nobody would do any kind of clinical trial for compounds that are already widely available in OTC form, and the only thing you would have is anecdotal evidence (i.e. noise) to know what works or not.

Whether this is the right way to incentivize research and development is a valid topic to discuss, however.
CNC machining relies on motion controls with higher order derivatives.

https://tenmilesquare.com/resources/iot-connected-hardware/a...

"Note: In the past TinyG used 3rd-order “constant jerk” motion planning, similar to a form of controlled-jerk motion planning that is found in some commercial products. TinyG has since moved on to even smoother motion control that uses further derivatives “snap” (4th derivative), “crackle” (5th derivative), and “pop” (6th derivative). As far as we know, no commercial CNC products advertise that they use 6th-order motion planning."
Damn you’re good
From the first sentence, "hard tech" is used without being defined. Does it mean CNC milling and metal-shaping? A rebranding of industrial automation using the SEO-friendly "tech" word? Would be nice to know.

While some of it is bs, it's good to see an acknowledgement of labor alongside IP as necessary, while being clear that the labor is more attached to brains than meatpacking or logging has been.

Large areas and populations are still stuck in extractive and mythologized industries like mining and logging. Some description of how this future can pull along those populations instead of leaving them farther behind in skills and exposure to the whims of commodities trading would be welcome.
I don’t think you can equate common law and Western tradition. Large parts of what I would call The Western world has the civil law system.
Server side transmission of data to Google would be illegal too.
It looks like SQLite is more popular in China than other regions:
https://ossinsight.io/analyze/sqlite/sqlite
I suggest moving.
Why didn't he buy more games???
Man, I know this wasn't really the intention of the comment, but I just read through that thread and got a little nostalgic. Crazy that was like 13 years ago. Sheesh.
Ask HN: Why do many recent comments have hyphens separating two paragraphs?
Recently comments with a sort of two-comments-in-one style, involving a hyphenated separation between body and postscript have been trending on HN.
Viral meme? GPT-4? What's up‽

≡≡≡≡≡≡≡≡

Why?? Is it because of the bipolar nature of the commenters state of mind, like:
here is one take (hyphens) here is another?
https://archive.ph/zgWKa
You speak for a lot of people.
Yea totally normal for a majority to use SMS in my country when both platforms send messages through their own encrypted servers. I don’t have this problem, nobody in my family does, so now explain to me why I should use matrix?
“Eleven healthy participants” — how is this being extrapolated as a general benefit? The conclusion that it helps only if blood pressure is high and that it doesn’t cause any issues if blood pressure is normal or low seems like a stretch.
Man that example sounds like a really subjective d*ck of a hiring manager.

If there's some objective concern and they have buy-in from their team and they raise it diplomatically, I'm 150% sure you'd be able to respond in a sensitive and reasonable way with a few minutes of forethought.

For example just about everybody understands that a huge company like that is not exactly constructed of evil individuals at every level. And someone with a mote of experience ought to know that a lot of times people join a Meta knowing there's probably a way they can make positive changes even against huge internal headwinds, and perhaps even demonstrate as much after the fact.

Just IMO.
The difference here, I think, is that you don’t have to use autonomous drivers. To the contrary, notwithstanding laws against it, you do have to share the road with distracted and drunk drivers.
Ask HN: Is OpenAI working on the next DALL-E yet?
What Happens If Your Roommate Steals Your $10M Lottery Ticket?
Why is it funny?
Elevators. You want to keep the 3rd derivative of position (jerk) limited, to have a smooth ride
Disagree completely, with respect. Suppose you hear someone with an exceptional voice on a commercial for Toyota or whatever. Why wouldn’t you want to find it on Wikipedia even if it’s the only commercial that person that has ever done it? You may not know about the existence of specialized wikis.
Sure am, and that response is proof of the point.
Three Practical Uses of Ruby's `Method_missing` Worth Knowing
This guy's like, "I see your Lisp in Lisp and raise you..."
Clojure, dart, and firebase.
One critique is this line in particular:

>I’m so sorry I hurt your feelings.

Please, do not say this. This comes off as dismissive and puts blame on the listener for being offended.
Also "knowing" and actually knowing are different things.

There had been research done as far back as that which came to the conclusion that it causes climate change. But that doesn't mean that the governing body at that time was aware of the research and if so, really believed it or just thought that the researchers are massively exaggerating.

I know that the research was done on the behalf of the government, but that doesn't mean that everyone governing/deciding on these issues had access to/were aware of the results.
That's because evangelicals "like" Jews so there can be someone around to gloat "we told you so" when the second coming happens or whatever.

Jews have picked up on this. Or just happen to be liberal.
Xfinity works just fine, and you haven't used starlink yet. grass is always greener.
Answer: we don't know, but most structures from past centuries are gone and replaced by new buildings on a regular basis, so it would not be surprising that we keep doing the same thing in the future as well, with only very "monuments" kept as tokens of the 21st century.
I didn't realize he was also behind Yars’ Revenge, which was actually one of the best Atari 2600 titles. He was given ample time to develop and test it, though.
Rust is actually portable
It's a simple language-technology that allows you to express nuance that's not available in English otherwise. We are reinventing German, Chinese, you name it.

BTW it's not really necessary to throw words like bipolar around, that's a tad extreme. :D
the key thing is that the expensive part of a cell network is covering all the low density areas. SpaceX would only need to build out a cell network in the densely populated parts which is roughly 10000x less area and use starlink for everyone else
Tesla Expected to Open US Supercharger Network to Other EVs, Applies for Funds
Slight tangent: even with the 600 million year scale, it's somewhat scary to think that we are living much closer to the end of the earth than it's beginning. And also closer to the end of life on earth than to its beginning.

I suspect, if humanity survives even for another 1,000 years, we will be advanced enough to consider moving earth further out. It would take enormous efforts and expenditures of energy, but we'd also have millions of years to do it.

I've read about some speculative mechanism we could use. Eg move earth by its magnetic field, or move earth via carefully tugging on the moon etc.
Did you consider letting people add topics they're interested in to things like the topics proposal? Context-based ads, some random ads, and just serving me ads on topics I opt-in to would be enough for me to turn off any ad-blockers, save for fingerprinting, but I believe some standards-based progress is being made there as well.
I haven't read the paper but if Wikipedia serves as a detection tool, I don't particularly see a problem using it. Perhaps the real problem is the non-Wikipedia, canonical systems to find these probably-relevant cases?
I worked at Google as a SWE for several years and hated it: I was paid less than at my previous job for doing less ethical work, it was hella less flexible than any of my previous jobs, the amount of bureaucracy and internal politics was above anything I could imagine, the amount of gaslighting from VPs and up (e.g. at TGIF) was staggering, and it all came with a mild cult vibe.

I guess the most disappointing part for me was Google's culture, or at least what it's become. I was surrounded by coworkers with a tenure of 10-15 years hired straight from college who had no idea about life outside of campus and google3. Those poor folks got brainwashed by HR into believing that most non-work related conversations or, god forbid, a joke will undoubtedly be offending to someone. Honestly, I think I'd rather work with jerks than in such a sterile, dull environment.

On the bright side, the tech was pretty good. I wouldn't call it great, but they have everything you'd ever need. The code quality was above average despite over-engineering. The praised culture of openness is long gone but you can still somewhat feel its scent. The email-centric approach to communication was 100x better than anything else I'd seen. And there's a chance you can get on a team that actually does some good (but those are typically at DeepMind, Verily etc.)

If there's no better option, I'd say to give it a try. After all, it's just a job.
> Poor nutrition leads to worse academic and social outcomes which limits opportunities for poorer kids. Good food can boost their quality of life, health and ability to contribute to the world.

I don't buy it. People were given poor quality food right after WW2 pretty much everywhere and still had productive and fulfilling lives no matter what - they actually invented the world we currently live in. Nutrition science is also junk (look at the ever-changing recommendations from nutritionists on what should be given to people, it's a running joke at this stage since they keep contradicting what they were recommending before).

> Every time you add a condition to a benefit like this, you have to create a whole government department around it.

With digital reporting and tracking for everything the cost of customized tax-breaks or subsidies is going down year after year. And many other countries are already doing that (condition-based benefits), so not sure what the big problem is to do in the US as well. Unless there is rampant incompetence at play in the administration, which is another problem altogether.
Again see the Heart sutra
And yet people still ridicule me as "paranoid" and accuse me of having "trust issues" for using an online pseudonym / "handle" and refusing to trust these corporations with any of the private data that so many of these service want to insist upon collecting these days… As if there's some valid reason why I should trust them with data that they repeatedly prove that they cannot keep safe from exactly this sort of "breach"… I just cannot understand how so many people can keep getting burned by these companies and still somehow manage to trust them with reams of private / personal data.
Ryan Bates had a series of videos called “RailsCasts” that I subscribed too. It wasn’t quick, but eventually I absorbed enough info to turn a passionate hobby into a career.
I guess it's a great exercise to set up a repository yourself in this way, but once you have experience with the technologies involved, it's much easier to just use a cookiecutter template [1] to set up your package. Another aspect to consider is that there are often different tools to achieve the same goal, thus, it makes sense to experiment until you've found your perfect package setup.

[1] https://github.com/search?q=python+package+cookiecutter
Imposter syndrome is real. But I think at some point we have to drop our false modesty and admit that we are the authorities on some things, even if our knowledge is still painfully limited.
There are definitely such things as life long ailments
The inverse rendering (Radiance Field Reconstruction (NeRF-like)) is very impressive. It can reconstruct physical models from multiple photos.

See the final results at https://mitsuba.readthedocs.io/en/latest/src/inverse_renderi... (scroll down a bit to see the reconstructed image vs the original)
You can take this a step further and completely automate the release of your package. That means the tagging, publishing and the GitHub release notes.

I don't have a blog post but you can see the process on my personal project https://github.com/DontShaveTheYak/cf2tf

Check out the merged PR's and the GitHub actions.

I even do alpha releases to test pypi.
But why would they, if they don't have to? Why run the risk?

Third parties were already creating fake profiles (for scamming etc). Then all Tinder has to do, is carefully deciding on how exactly they fight those fake profiles, to apply 'evolutionary' pressure in a direction they like.

No need to get their hands dirty.
I don't understand. It was their role at the time - why do they have to convey repentance?
Option 1: Have only Edge installed.

Option 2: Install Chrome. Edge will stil be present because I cannot remove it.

I choose 1 every time. At least Google is not getting my data in addition to Microsoft.
You must not live in such a country.
I'm still annoyed that gov.uk, all the while being praised for great web design, happily recorded all interactions between UK citizens and UK government, and sent them off to google.

And refused to engage on why that might be a bad idea, because hey, we find it useful, and Google pinky-swear they anonymise everything.
Somebody is trying some trickery here...
I actually had a similar upgrade to do that I've been postponing for too long. I ended up rebuilding all functionality on the server on a different server -- this time also creating the necessary automation for both provisioning and migrating, so I can rebuild it much cheaper next time.

Did it take longer than slogging through a dist-upgrade? Probably. Does it cause some more inconvenience for users, like changed host keys and upgrades of software that might not have needed upgrades? Yup, definitely.

Does it let me sleep well at night knowing I'm no longer dependent on a specific machine staying un-broken in the near future? Sure as hell.

----

(I also ended up splitting apart the independent functions the machine provides onto multiple machines, one for each purpose. This increases my exposure to machine failure, but simultaneously limits the blast radius. That's a good trade-off, for the most part.)
The exclusionary rule has been gutted over the decades. Police and prosecutors have long known how to work around it.
It cuts the other way with stock market earnings reports. There are blood baths when "profits are down" when actually profit growth is down on record profits.
There is a very enjoyable Let's Play, with a few added twists, of Superman 64 here: https://www.youtube.com/playlist?list=PL6537A2F60C44CF57

The first twist is that because the in-between "fly through the rings" stages are so incredibly repetitive and boring, the player/presenter uses them for what he calls "in-flight movies" that explore other aspects of the game, like its development history. Meanwhile, the boring ring stage continues in a small picture-in-picture cutout.

The second twist is that this Let's Play has gone on for so long, it's become a bit of a running gag. There are years between episodes, but it's still going. The last episode is from last year, over 10 years after the first episode. It's always a highlight to see a new episode pop up in my subscription feed.

And then the game is really pretty bad, but in a way that also makes it pretty entertaining to watch.
Musical Polyrhythms
One of these cases is a class action on behalf of people who have been wrongly arrested because of spotshotter - the case is also trying to get the police to stop using it because of this - if it's wrong most of the time police do not have probable cause - they have improbable cause
Have a holding company outside US jurisdiction that owns both a US subsidiary and an EU subsidiary, then make sure the US subsidiary never gets EU users’ data.

Or lobby to rescind the CLOUD act.
for about the same budget you could buy a 4-bay 2.5" nvme nas enclosure and a single 30tb ssd, and have 3 bays to expand if/when you need to
> My gut feeling is that shotspotter mostly works and is mostly accurate

I don't want to base our legal system on your gut feelings. If ShotSpotter is mostly accurate, then they should have no problem releasing the requested material and proving that's the case.

Otherwise I will have to assume it's just the magic crime detection box as described above.