skysight-inc/HackerNews huggingface dataset:
High molecular weight assemblies of Abeta have been repeatedly identified by numerous researchers from human tissue and other sources. However, similar to myself, Derek Lowe didn't investigate the voluminous literature on the topic to see if the specific Aβ*56 species has been found in extracts of human tissue by others.

With a little extra searching, I found this article below which does appear to replicate detection of a potential 56 kDa form of Aβ in human tissue by western blot of SDS-PAGE gels, as shown in the Lesné paper (Figure 1), though they express concern that its true concentrations may be very low and may be artefacts.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1582-4934...
I'm not interested in disputing the veracity of the claim; it's not worth my time. I'm merely pointing out that this is indisputably a popular neoreactionary conspiracy theory. It's a pointless insult to this forum's intelligence to pretend otherwise.
> but that's only because they don't envisage having net-zero planes and ships by 2050.

Don't be disingenuous.
This is a relaunch of another such plan over a decade ago. Yawn.
If governments ban cash, it's back to barter. Drugs/alcohol/cigarettes, weapons, food, gas, gold and silver...
Magnasanti – The largest and most terrible city of SimCity
You don't need to quit tech. You need to find a position that helps solve real problems for the greater good. If you think about it, companies like Apple are very pro-privacy and don't make money by selling data or tracking folks. Or look into other companies like those non-profits like Mozilla or Signal. Your pay will go down but you'll be content. Or maybe, you could look into building your own company.

Facebook is a cesspit of delusion and the "metaverse" initiative they took takes us to a point of no return for all their apps. Tiktok I would say is even worse given how we basically have millions of young teens oscillating on the borderline of being "famous" and sexualizing themselves. Stay away from such social media platforms or those that offer completely "free" products and you are good.
Yeah, from the reading I have done on this, the largest draw is locality, if you were able to produce gasoline even at $20 anywhere in the world, you would definitely attract the attention of militaries.

From this article [1] the "fully burdened" price of a gallon of gasoline was near $400/gal, factoring in security, transportation along every step. But this price is disputed and variable, an excerpt:

"To be fair, there has been a lot of debate and controversy on the true cost of fuel. According to National Defense Magazine, basic gas costs $2.82, and then quickly rises to $13 and $42 depending on transportation methods, and up to $100 to $600 in some hostile areas. In the past, the Pentagon has been criticized for not knowing its true fuel cost, which was a more obvious issue a few years ago when oil prices were over $100 per barrel. Even even with today’s cheap gas, the military is still paying more than we could ever imagine."

[1] https://www.cnbc.com/2014/12/17/you-know-whos-not-getting-ch...

For a military to produce jet fuel on an aircraft carrier and gasoline in a remote and hostile locale, the supply chain advantages are staggering.
> however that overlooks how difficult it is to collect such data.

It is very difficult in physics as well. Do you know how hard it is and how much effort is involved in building the LHC? Or Ligo? Or the JWST? Or ITER? They cost billions of dollars, thousands of scientists and decades to plan and make before you even get science data. Science is hard! You need to put the work and effort in, because otherwise you can't say anything about the nature of things.
Perhaps, if hundreds of billions of dollars of money laundering were comparable to consumer spending taxes.
>Governments in the US already exercise this power

Yes. And now they will have it at 100x the reach, 100x the efficiency, and with automatic monitoring, install rule-change enforcement, and so on.

I never understood the tendency to say "It's already a thing" when the new development is so quantitatively and qualitatively different from what existed, as to be a whole new thing...

It's like "We're at war, the towns are bombed, and people are getting killed? Big deal, people were already getting killed in murder cases and gang shootings".
Both awe inspiring and frightening, considering the source.

Technological utopia meets sociological dystopia.
The same loopholes that they lobbied for. Soooo much better.
Regardless of all the FUD against Pluton, it has a great feature, it is yet another CPU with hardware memory tagging, as the last resort against C flaws and derived languages.
So this turns into security theater because ultimately they can't trust those third parties too.
I have been journaling for 9 years now. Actually closer to 12 but we'll discount the first 3 years because it was done haphazardly handwritten in notebooks in fits and bursts. Repeatedly throughout the journals I wrote about how circular it felt whenever I was examining the deeper self. It felt like I had written this or that before and then I came to the realisation that the deepest sense of self or sense of consciousness never really changes throughout life. You are who you are. What surprised me was the regularity that predictions or goals written in the past would come true in the future. Seemingly impossible (within a realm of reason) things would always come true given enough time, enough persistence and enough continuous progression. And if it hasn't come true yet, have you moved along the scale of making it happen?

That's where journaling becomes powerful. It lets you hold yourself accountable, lets you measure your current self against your past self. It lets you document those little life victories, those turning points to judge whether a past decision was good or not. Life is a combinatorially explosive decision tree (borrowed from John Vervaeke), journaling helps you to better guess the best future path and keep you on it.
Does squeenix explicitly allow FFXIV mods now?
lol imagine still buying this.

You have even less privacy with BTC than you do with fiat.
Ask yourself why this hasn't happened to gold.
Thanks, looks like yachts would also be exempted by the EU, https://www.transportenvironment.org/wp-content/uploads/2022...

> In July 2021, the European Commission published a set of proposals to decarbonise the maritime sector. However, the proposed carbon pricing scheme (ETS) and the low GHG fuel standard (FuelEU Maritime) will only apply to ships above 5,000 GT and exclude a number of ship types such as offshore vessels, fishing vessels and yachts.
> they hate paying taxes. So they want to shift some of the taxation burden on to the middle class and the poor.

I don't understand how making middle/poor class pay more taxes spares the rich from taxes.
But XMR is private?
Crazy to think that Mac/Windows hashes and phones home every binary you run and nobody really cares. Palantir should take notes.
Dictator announces mega city, just like dozens of dictators before him. See: New Cairo City
Best Math Puzzles?
My favorites:
1. Moscow Math Circles
2. Museum of Math’s Mindbenders for the Quarantined

Have you liked these? If so, what is similar?
I tried Instagram in 2020 but shortly deleted it for precisely this abuse.
Light-based sensors set to revolutionize on-site testing
What "conspiracy theory"? Several government officials clubs and "policy proposal" bodies have openly stated plans to that effect, and even used those very terms. They have even published public policy wishlist books about it, it's not like they've been shy about it.

That's a conspiracy alright, in the sense of coordinated action to specific goals, but hardly a "conspiracy theory".

But of course, if you tag it a "conspiracy theory" knee-jerk idiots will consider it to be the same category as alien abductions, the illuminati, and Elvis being alive...
You’ve supplied the labels, I’ve supplied the critique. I don’t agree with your labels, am I pretending?
Helium is a terrible use case for cryptocurrency. Cryptocurrency is for money, only for money, and not for any other purpose.
I'm not sure why this is meant to make me feel better.

The elite would bid up the price of the credits so they can fully enjoy their yachts and private jets.

It would still be crickets for proles.
At which point you are probably guilty of "structuring". Which is a crime all on its own.

Also, that only holds up until someone actually looks at you.
Depending on where you live, you can get discount too. For example, I get this:

>Hello! It looks like you're in India, where this zine might be expensive.
If you need it, please use code <redacted> at checkout to get 70% off the regular price.
Nim is a bit of a sleeper in that department as well
The question isn’t whether there’s some way to do arithmetic on raw pointers, but whether you can take a pointer to a subobject and expect the GC to keep the object alive for you. In Go you can do this, but you can’t in Java or C#, I believe.
It is fixed. Thanks again.
Poorly built drivers, yet again - no EMI suppression. Virtually any switch mode power supply that has no suppression would have done that. The LED driver in virtually all cases is some SMPS.
As someone who was here from day two, this is not how old HN was. It was many things to many people, and it’s very difficult to break out of the illusion that rose-tintedness tends to give us. (Guilty of it myself.)

HN has been consistently contrarian. That’s about all that you can say without quickly becoming mistaken.
> How so? If I buy some bitcoin face to face [blah blah]

You just described the benefits of a cash transaction. If the government is your adversary in this scenario, what's stopping them from cutting network access and rendering your Bitcoin immobile? Starlink and solar panel? For everyone?

I'm really getting sick of this libertarian drivel.
I was using quotations in the sense of so-called - not a direct quotation.
I would honestly love to see more journals that look like this.
as an Israeli, I really think this is a good thing. I hate the use of cash. I understand digital privacy and liberal concerns, but apart from the theoretical liberty taken, most non-criminals dont use cash and prefer digital payments.
Reminds me of computer magazines bundled first with cassettes, then floppy disks then CDROMS, 80s to 90s. Occasionally some other gadgets too. Everybody like us was buying them.
Neat. I made a Telegram bot so that all users get access to these emojis:
@emojimixingbot
It works only in inline mode
Yes, Gary Busey’s son playing himself.
The US is a hostile power everywhere else in the world. And then also for about 4-8 out of every 8 years to its own citizens.
Next-Generation Secure Computing my ass.
I follow her on Twitter. It is very common for experienced programmers to reply saying they learned something new or understood a concept better.

For example: https://twitter.com/willmcgugan/status/1533056162417070081

>Just read How DNS Works by @b0rk. I love how easily digestible this is. A 10 minute read and i feel I have a solid understanding of DNS! And I’ve been a web developer for more than a decade.
I found DejaVu Sans Mono to be a bit thinner and easier on the eyes. Either way is fine really. One of those whimsical decisions, I guess.
Most of these problems are probably already solved or could be solved. You are of course using dry cleaning services in some form. Fire suppression systems are built in. The structure is quite narrow, so you have a view to the outside from pretty much anywhere, and it's not much worse than any skyscraper, better probably because of (hopefully) better design.

As to social aspects... That is my major concern also. Of course this city has a police force and would clean up anybody blocking the central hubs. There is no street btw, but rather different kinds of corridors for walking and trains of different speeds and ranges. I guess it is relatively easy to disturb the system, on the other hand if realized there would probably be an authoritarian kid of police force making sure nobody does.
To be clear, she didn't say anything pro-life during the speech. The students walked out because they didn't want to hear a pro-life person talk at all, even about unrelated topics.
> High unemployment, horrific air pollution, almost no education, medical and fire services are absent, and residents do not live to retirement age. The police state made it possible to maximize the size of the city, while retaining full control over the citizens - but it minimized the quality of life and effectively destroyed free will.

> Magnasanti is a “cage” in which six million “economic slaves” are enclosed.

Amazing. -ly awful.
Not with single use wallets. If you have multiple transactions yes but if you create a new wallet put btc in it and spend it all and each time you spend you create a new wallet it is much like cash.
The idea is that you make holding a lot of cash much harder to work with on day to day life.
That means the incentives for that are far lower.

It also complicate illegal activities in general.

The idea isn't that your typical criminal will say: "I'm okay with dealing drugs, but the law about 6K NIS is where I draw the line".

The idea is that once they get the money in cash, they have a problem actually using that. So they have to go into addition hurdles.

Basically, it makes illegal activities more expensive.
just found dnd on iPhone too. Feeling so much better.
My bet: terrible capacitors and the driver ran hot (which caused the laps to leak out). Bad driver.

Honestly I have no clue why LED light are so poorly built nowadays. There is absolutely no technical reason for it.
But it's still the case... Stallman is quoted every day around here: https://hn.algolia.com/?dateRange=all&query=Stallman&sort=by...
> And crickets don't comply with Jewish dietary law.

If you mean specifically the religious law, then locusts/grasshoppers are the only kind of insect permitted to eat (see Leviticus 11:20-23). Ancient prophets consumed them too.
Is the Honda-e available over there?

That's a pretty nice mini electric vehicle.
> a) Like Japan's lease law[1], it would be possible (and preferable) to limit lease periods

Your source effectively says the opposite-- some leases are limited, but "With an ordinary land lease right, the lease contract period is fixed but in practice can be renewed almost in perpetuity." and "The lease contract period under the Old Land Lease law is fixed, but the lease can be renewed almost in perpetuity."

Even the fixed terms for non-commercial use are generally very long-- "Land leased out to be used for single-family homes and condominiums can be leased out with a fixed-term land lease. The contract period is 50 years or more. "

> So even if you follow that avoidance strategy, I'm going to buy your land on the cheap.

I bid the NPV of the lease + the NPV of the land after the lease. If you outbid me, you're taking an economic loss. I can even afford to overbid a little, because I'm just paying a small percentage of my bid.

E.g. say a sane discount rate is 5% per year. Lease is 50 years. Lease payment is $1/year. True value of the underlying land is $500k. Value of land in 50 years is estimated to be $1M. Tax rate 1%.

NPV of the lease payments is $19. NPV of the land is $92,000. I bid $200k and pay $2k in tax (compared to $5k).

Sure, you could bid $200,001 and get the land, to get an asset with a net present value of $92,019. This is not a favorable transaction-- even if there's some building residual value at the end.

In the end, the only way to value the independent value of the land is going to be from some kind of assessment process. A bidding based scheme is not practical: separating the value of the land and building is really hard. (And if we start having people judge whether the pricing of leases, etc, is fair-- that's effectively assessment).
I changed the indentation of lists to be smaller. At first just for mobile via media CSS, but then it seemed more readable for desktop too. So it should look better now.
> over half of the coast is Saudi by week 3

So the proposed strategy involves taking out the main rebel-controlled ports as well as their fisheries while doing aesthetic damage to Saudi Arabia? (Yanbu won’t be disrupted by an oil spill that far away.) This is nonsense. Hell, I see more sense in Riyadh busting the tanker.
The theory is that broadening the tax base will create a large constituency with a vested interest in responsible government spending.

Or perhaps, more cynically, for lower taxes overall.
It's not idiotic, it's a theoretical scenario on how CO2 emissions could be reduced to zero (not net zero, actual zero) by 2050. And they don't "call for" it, they say that if the goal were to reach zero emissions by 2050, all ships that still burn CO2-producing fuels would have to stop doing that by that date.
Nah, keep the mirror. Then you can focus the light into the middle and you have a built-in incinerator for any dissidents / journalists who might pop up.
Anyone can issue (paper) cash.

Cash is just a paper IOU for some other thing. With 100 dollar bill, that thing is 100 USD.
You could also issue paper for gold backed IOU, or gold itself, or bitcoin.

https://en.wikipedia.org/wiki/Wildcat_banking

Counterfeiting paper is a problem, so you need force against this, and this is why the government is generally involved. But what kind of paper counterfeiting is enforced against, is just a legality. Currently the wost thing to counterfeit is 100 dollar bills. Law could be changed to make it equally bad to counterfeit gold bills, or bitcoin bills.

Saying bitcoin is less private than cash is a category error.
As a 60+ geezer who is back to doing what made me happy in this business before career climbing and salary chasing took me into a bad place or two, let me commend you on realizing that contentment is what life is really all about. I truly wish I had understood this at 30 rather than finally and fully realizing it at 60.
Coinbase (YC S12) faces SEC probe over securities
It acts as a "pre-emptive" tax shift. If more people pay taxes there's going to be less pressure on the government to set an ever higher tax rate, because now they receive more money while levying the same amount.
If apple is pro privacy, they wouldn't be putting lidar scanning on their phones.

Whether it's enabled or not, Lidar is military-grade tech that has no place on most cell phones,

Let's not act like the entire industry isn't heavily invested in data collection... It does damage to real discussions about privacy and consumer protection for everyone.
> Conversely I doubt that Asta would be considered road worthy anywhere in the EU. Actually I think EU countries like Bulgaria and Romania would benefit from some of these super-cheap vehicles.

Bulgaria and Romania are EU countries — that is, under the same regulations that Germany has. Even if Asta was road worthy there, people from lower GDP EU countries would still prefer continue buying high-mileage, but somewhat well-maintained vehicles from Germany.
The government needs a certain amount of revenue. If some people get away with cheating on their taxes, then the tax rates for everyone else need to be higher to get that much revenue.
turnkey program(s) per google search:

Cronitor : https://cronitor.io/docs/using-cronitor-cli

Nagios : https://exchange.nagios.org/directory/Tutorials/Other-Tutori...

https://jaytuckey.name/2020/10/30/new-project-coconut-deadma...

https://www.saashub.com/compare-cronhub-vs-zabbix?ref=sideba...
As noted in the link: there's "the Great Reset," which is a broad collection of economic and social policies that generally prioritize environmental and social action, and then there's "the Great Reset," a neoreactionary conspiracy theory that says that the former is really about getting people to live in the pod and eat the bugs.

The former is a "conspiracy" in the sense that there's a bunch of policy being written and applied by various important people, the legitimacy of which you're welcome to contest. But it's not remotely consistent in content with the conspiracy theory, which is a redressing of the iconic "The Other (Jews, Muslims, Last Night's Meatloaf) is going to take away Everything You Value" conspiracy template.
Just-add-water CSS animations
Is it okay to talk about language as a meta-topic? I try not to stray too far into that, since it’s usually boring for readers. But one thing I was surprised to learn is that “begs the question” is only correct when you’re describing a chain of circular logic. “Raises the question” is apparently the right term for the general case. I felt a little duped, since I’d been using “begs the question” for years without looking into its origins.

But of course, that begs the question of whether language is defined by how people use it. :)
I don't really care for the reason, why can't we as consumers opt out if it's consumer oriented then? For me it's not even about the egregious security and privacy implications -- I just simply want the (illusion of) choice w/r/t silicon rootkit 'features' that I'll never use.
> Lidar is military-grade tech

encryption is military-grade tech too.
Look up "paper gold".

When you sum up the amount of gold people "own", it is a number 10x higher than the amount of gold in existence.

The reason it is 10x and not 100x or 1000x is that Gold is not used as money.
Mildly related. A lot of countries have limits on physical cash transactions. Germany doesn’t. You can buy a mansion and pay for it in physical cash.

Apart from the tax implications, it is an effective way to launder money. Apparently organized crime really likes this and buys real estate en masse.
The movie "Phase IV" is the perfect movie to accompany this research.
This is absolutely brilliant!
Like all things in life, "insult to intelligence" is meant to invoke the average, not the individual. You aren't accused of pretending.
I made a post about the potential of a negative leapsecond a week ago -- https://news.ycombinator.com/item?id=32125171

I was partially motivated to write about leapseconds because I'd spent much of the day trying to construct leapsecond tests for my telescope pointing code. You're absolutely right, leapseconds don't help astronomers.

Casual astronomy will do a one star alignment, so in effect they'll point at a star find out where it is and from it effectively compute the UT1 UTC offset (along with correcting other sources of pointing error). This applies no equally for electronic or manual pointing.

More serious astronomy with use the IERS Bulletin A data. https://datacenter.iers.org/productMetadata.php?id=6 Without it you UTC would only get you within 0.9 seconds (and you won't know the other polar motion terms), so you might as well just platesolve. If you do have the IERS data you have to then back out leap seconds.

You note you need constantly updated tables to do that, but it's worse than that: All over the place systems are getting their UTC replaced with leap-smeared UTC without the operators knowledge. You can't just back out leapsmear especially if you don't know you have it.

I'm sure leapseconds sounded like a good idea on paper and when only a small number of especially exotic systems needed to deal with them. But the pervasive computerization since the 1960s has increased the cost of leapseconds by many orders of magnitude.

> But eventually it will build up enough error that it eventually has to be addressed

Yes, in 4000 years or so people can adopt new timezones that are shifted over by an hour. We already have comprehensive support for timezones, and support for them changing (as they're fairly vulnerable to political whim), computers handle them reasonable well-- and importantly they're primarily a presentation element so they don't mess up precise timekeeping. Maybe in 4000 years no one will even care-- perhaps everyone will have finally switched to SWATCH INTERNET TIME. But regardless, a timezone addition/change every few thousand years is a much better situation than we have with leapseconds.