skysight-inc/HackerNews huggingface dataset:
> Dr. Kaplan reports that surgery immediately alters the activity of more than 5,000 of the 22,000 genes in the human body.

What does this mean? How is activity of genes altered?

> But surgery only alters the intestinal tract. That tells you, Dr. Kaplan says, that there are whole classes of signals coming from the gut and going to the brain and that they interact to control hunger, satiety, how quickly calories are burned and how much fat is on the body.

This makes sense - you're disrupting signaling. But what does altering genes mean?
any plans to add IPv6 support? not reachable from my IPv6 only VPS.
I would be very interested in that!
Building a SaaS Product in 1 Week
Technically this should mean hiring people from Google is a bad idea because they won't be as productive without access to the tools that make them so capable at Google...
I had to read up on these folks to understand that one of them was shot dead at 20, and the other attracted tuberculosis and died at 26.
There are a lot of ways to slice those statistics. I’m guessing they got theirs from “Most Americans open to some restrictions on abortion” in the Pew data. https://www.pewresearch.org/religion/2022/05/06/americas-abo...
Working in public – our docs-as-code approach
I enjoyed Good Will Hunting, it is easily the coolest commutative diagrams have ever been with the general public. It was also released 25 years ago, before approximately a quarter of the world's population was born. I don't think that is why.
I also think it is partly as the tooling is not there yet - especially in the typical case when a project depends on lots of external dependencies.

I am looking forward to new set of bazel rules being worked on for eg. https://github.com/aspect-build/rules_js and https://github.com/jvolkman/rules_pycross which will makes it more idiomatic to work with existing language ecosystems.
The secondary server can cache the result, so that only the first time there's a signal to FB.
>"1) Privileged instructions, like IN/OUT, WAIT, or SGDT. These instructions aren't even usable outside the kernel, and there's no way to represent their effects in pure C anyway."

Could you elaborate on this? I understand you need to be in ring 0 for these instructions but you still need be able to compile the kernel. Or I am completely misunderstanding something obvious or missing your point completely?
I do not see the possible relation between hemophilia and Alzheimer as hemophiliac do not require transfusion, or do they?
The only tool that I know of that uses YAML for diagrams is Ilograph: https://www.ilograph.com/

But yeah, ASCII for diagrams seems like the worst of all worlds: manual layouts, slow to create, impossible to maintain.
GLU is proprietary lost code, but did anyone find the old pop-2 plucid code?
or the new forth-like magwa?
Sounds like you've won then!

I'm glad that there's not only hope, but hope to successfully pass that hope on.
Looks nice and something I could use.

However, I have a rough time buying into apps that are built for one platform only.

I move daily between Mac, Linux and occasionally windows and want the tools I put time and money into to be available in all platforms.
Wow. I lost much less than that, a bit more than 20 lbs, in the last 2 months and it feels like a big change to me. My old clothes fit again and I don’t snore as much. It’s different for everyone I guess.
The problem with "promise" is that it is ageist and hard to measure. And to be honest, being "promising" can actually put more psychological pressure on the recipient.

I think in general societies should strive to have equal and realistic opportunities across the board rather than try to fix it with a prize for selected young men.
>The famous "Windows 95 won't work right on a fast K6-2" bug is based on this problem

Wow that's pretty interesting on it's own. It turns out a program was trying to figure out long the LOOP instruction would take to run by running it 2^20 times and dividing it by the amount of time taken in milliseconds. On a Pentium 3 this took 17ms, but on a K-2 (and faster) this could take 0 milliseconds.

https://gigazine.net/gsc_news/en/20200606-windows95-failed-s...
WordPerfect for UNIX Character Terminals
Did you read the parent comment? Wiles received two other prestigious prizes in addition to the "special IMU silver plaque" from the Fields committee, so I don't think you can say his achievement wasn't properly recognized.
How many bottles can one Tour de France rider stuff down their jersey?
CLI tool for converting txn statements from Singaporean banks into a sane format
Hello. I am an expat based in Singapore. I use GnuCash for managing my personal finances (it's a great tool). I was unable to find a way to easily import bank statements (CSV files with transactions) into GnuCash without all sorts of weird conversion errors. To streamline the process, I wrote a Perl-based tool for automating the conversion into something GnuCash can easily import. You might find this useful (or not!). Have fun!
Article might raise an interesting question, but the methodology used to determine if his system's binaries use the entire available set of instructions is dubious at best. He doesn't describe what operating system or distribution he is running, or how the binaries were built at all.

If it's on Gentoo with all the optimization settings tweaked out, it may be useful data. If it's on something like Debian where binaries are built to a lowest common denominator, that's... much less useful.
It's hard to argue that the spirit of the competition has not changed since it started. Roth would not have won the fields medal the way he did these days, he pretty much won it for a single paper.
Thanks for the kind words. That's a fair point, it might be warped, although the micro-optimizer in me is leaning towards just losing more weight and seeing if I notice the change after some more progress.

One thing your comment reminded me of -- I was surprised to see a lot of my sense of weight loss came not from a mirror, but just feeling my old fat body parts. It used to be more dense, due to the fat, now it feels a lot more like excess skin. The skin is almost as big as before, but much lighter and more hollow, if that makes sense.

[edit: added "sense of"]
There are some absolutism in there which are not correct

> Because of this, Go developers lean on the standard library more than many other communities and generally hold it in high regard.

As a .NET developer I can just laugh here. Compared to JS and C/C++ this is accurate, but .NET, Java, PHP, Python this is the normal case. I would say the majority of platforms for application writing nowadays come like that. Which supports your argument, just that it is the norm already for a long time.

To your generalized argument: i do not follow that. Yes, modern languages have the benefit of knowledge, but the old stacks are massively catching up. Package manager and libraries is a solved problem (except for C++). The most interesting aspect this should focus about are modern compilers. The ones like C# or TypeScript which expose their services (AST, type checking, etc) as language servers. Here old platforms (PHP, C++, Java, ...) have massive pains because rewriting the compiler is the opposite of fun and new languages could start like that (e.g. TypeScript).
Delightfully relevant HN thread: https://news.ycombinator.com/item?id=35079
Unknown unknowns are also true of covid. We are only beginning to see and document the effects of long covid.
But the whole argument is toolchain integrated with an IDE (the I, remember?)
Well in good tools (Tableau being one of them) there is always the raw SQL query somewhere (ideally with parameters) so that you can do the heavy lifting in code but style use the GUI for quick and nice interactive rendering.

PS: Well some tools are even cooler like QGis for map making. The GUI of this FOSS tool is heavily parametrizable and fully extensible/scriptable in Python/QT.

There is quite not not yet an equivalent in BI world...
This approach also extends to embedding languages with different disciplines in a faithful way. With Haskell's rich system you can embed a concatenative, effectful DSL using regular functions[0].

[0] https://gist.github.com/siraben/03510d1bf4d73b6958655887bee6...
Intel and Apple: Best Friends 4-Ever (2008)
Well, Google is a large enterprise, and in my experience most people that primarily worked at enterprises have problems adapting to working for startups, for the exact reasons you describe. I don’t think that’s unique to Google at all.
I suspect you're interpreting this more literally than I am. In any case,
Dave Chappelle explains it more eloquently than I can.
https://www.youtube.com/watch?v=s5hu7o2Q62k
Smoking is optional. Guns are optional. Nukes are optional. Still needs to be regulated. How long before society accepts that damage is being caused by mobile phones and social media?
I don't think ASCII diagrams are a very good idea, but drag-and-drop tools bring their own problems for engineers. I wrote on this earlier this year: https://www.ilograph.com/blog/posts/its-time-to-drop-drag-an...
> You used it as something that is inherently bad and needs to be avoided.

Yes, that's indeed what I think.

> already so set in their ways that there is no point to debate the issue.

So I'm not allowed to use words with negative connotations (or have values different than yours) lest I be deemed "set in my ways"?
The clothes thing was a huge motivator for me. I was at 2X (in US measurements) and was about to burst out of those :) (edit: I neglected to mention, congratulations. It's no small feat to lose weight.)
no way! i drink exclusively light roast espresso. yes, the sourness is pretty much always there. but there's blueberry (my personal favorite), red berries, tea, lemon, cinnamon. getting a balanced light roast espresso requires going much higher ratio to get a high enough extraction. try upping the temp to 95*C and go for 1:3 or higher.
Surprised to not see gmail.com in the list[1].

[1]: https://drewdevault.com/2021/02/25/Gmail-is-a-huge-source-of... , https://news.ycombinator.com/item?id=26265329
Turn key phone with graphene is preinstalled
Would feedback on pricing, marketing or anything else.
The question (well, one question) is why would we suspect the lack of a test indicates a bug? For most non-trivial software the possible state-space is enormous and we generally don't/can't test all of it. So "not testing the (full) behaviour of your application is the default for any test strategy", if we could we wouldn't have bugs... Last I checked most software (including Google's) has plenty of bugs.

The next question would be let's say I spend my time writing the tests to resolve this (could be a lot of work) is that time better spent vs. other things I could be doing? (i.e. what's the ROI)

Even ignoring that is there data to support that the quality of software where mutation testing was added improved measurably (e.g. less bugs files against the deployed product, better uptime, etc?)

Is this method better than just looking at code coverage? Possibly none of the tests enter the if statement at all?

EDIT: where I'm coming from is that it's not a given this is an improvement to the software development process. It seems like there was some experimentation around the validity of this method which is good but like a lot of software studies somewhat limited. It also seems there's a lot of heuristics based on user feedback, which is also good I guess, but presumably also somewhat biased.

The related paper has a lot of details including: "Since the ultimate goal is not just to write tests for mutants, but to prevent real bugs, we investigated a dataset of high-priority bugs and analyzed mutants before and after the fix with
an experimental rig of our mutation testing system. In 70% of
cases, a bug is coupled with a mutant that, had it been reported
during code review, could have prevented the introduction of
that bug."

Which should imply(???) that 70% of "high priority" bugs can be eliminated during the review process by using this sort of mutation testing. Seeing data to that effect would be cool (i.e. after the fact) and if it's real that'd be pretty incredible and we should all be doing that.
That would be 350,000 calories, or about 7000 calories a day? Wow.

I guess your must have body must have dumped fat directly out through urine?
I don't think Google are anti birth control.

We should blame the American voters for this mess.
With all due respect, not knowing your exact position, working in healthcare may not be more relevant to the topic the same way an average software dev would have a hard time fixing a deep-lying race condition in the database software.

Healthcare is a huge field, an orthopedic surgeon’s opinion for example should hardly matter over that of a virologist.
the very same comment you are replying to mentions the Abel prize and the Wolf prize for recognizing general mathematics achievements, which if you look at the recipients over the last 2 decades, are almost all over 40 (usually white men who typically get tenured as mathematics professors and have the time and resources to focus on research).

I appreciate OP for explaining that the field recognized this pattern and made a step to try to encourage future mathematicians to have something to aspire to.
Using grids in interface designs
eventually the maillard reactions are no longer developing flavors and are just burning. no different than a bagel, pizza, steak, or chocolate.
19. Get websites in bulk

If you want to read a website just get a whole thing , and read it offline.

That way nobody knows what you are reading except you. There are projects like Kivix that will enable you to read websites in .zim file format and browse it offline.

This will help to confuse digital fingerprinting.
Could have something a little more usable if you pasted into a tool like https://asciiflow.com/ and then copied your edits back into source.

Or an editor plugin with something like the automatic table formatting you get with emacs org-mode.
> You don’t have to drink shit coffee to save money.

But then your choice of coffee would cost me an extra 100€ every month. For me, preparation is more important than the coffee and even roasting date. I prefer cheap-ish (supermarket or slightly above) coffee (usually 6 months+ since roasting) with a French Press over fancy freshly roasted drip/filter coffee.
I use the Right Click Search addon, select text, and "search" with Google Translate.

https://addons.mozilla.org/en-US/firefox/addon/right-click-s...
You're ignoring ventilation, air filtration, sanitization, quarantining, and a bunch of other things.
My brother freezes coffee beans. Is that a good way to preserve the taste?
Until Chrome stops cutting my battery life in half, I won't be using it. Firefox is much better in that regard; Safari even more so.
Did Intel actually shrink the Core 2 Duo for Apple for the Air?
"Trust the science" when there isn't any public study or experiment really means "trust the conjecture" but that's not so great for PR.
They will probably be just as productive as all the other employees but they will be sightly unhappy about how incredibly lacking the non-google tooling is because they know how productive someone could be.

Source: Googler but still writing lots of code outside of Google and constantly think to myself "why is this so needlessly hard? Why does nothing integrate well?"
> It's not a critique of the idea alone, it's forcing it into context.

Exactly. But switching to individual context around societal question is the problematic argument here. Properly contextualizing means to use individual cases to explain impact, but that is not done here.

Society is formed by many individuals, and it doesn't necessarily matters what most of them do to address a particular problem. We have division of responsibility.
There isn't any pure C code you can write which would be expressed with those instructions, in the sort of way that MUL would be an expression of "a * b" (for example). The C virtual machine doesn't have the concept of an I/O port or a global descriptor table; the only way of interacting with these features from C is to either use a CPU-specific intrinsic (not available for these instructions) or inline assembly.
It's just prizes guys. Everyone in mathematics knows that 'win a Fields medal' is not a realistic goal unless you're like Terry Tao or Peter Scholze - you need a lot of luck as well as talent.

There are other math prizes available that try to fill the gap with the Nobel prize - most notably the Abel prize, and the Wolf prize, these should possibly supplant the Fields medal (or maybe the Fields medal should just lose its age restriction). There are also other prizes available for young 'promising' mathematicians, for example the SASTRA Ramanujan prize in Number theory / combinatorics, or Clay research fellowships. I don't know if it makes sense to move the Fields medal closer to this now, given how it's outgrown its original prestige.
> People here are directors of strategy or vice presidents or head tech coordinators or editors at magazines.

The author considers this the Elite Class? Those are just glorified middle management titles. Even most CEOs don’t qualify as elite. I got news for you…
He is saying you can not change sex the innate characteristic, which Title IX protects.
mandated means more government which is more energy spent, i fear.

white roofs are definitely a thing here, and lots of white cars, and like the other post noted they're researching white pavements.

i never understand the people who buy black cars in this UV and just heat climate.
You don’t need a crystal ball. This isn’t a housing crisis.
Who decides what are "facts"? During the COVID-19 pandemic, social media companies censored many posts as "misinformation" which later turned out to be accurate (or at least not provably false).
Or bookmark about:profiles.
Not when it impacts peoples' right to privacy and control over their own data. Do you work for Facebook?
An anecdote about the jank and pauses: I have... many (D:) tabs open in Chrome right now, and I discovered that setting Session Buddy to show the number of tabs in its icon causes the entire browser to pause for a fraction of a second every 1-2 seconds. Clearly this is because Session Buddy is calling the "get list of open tabs" API method, which for all I know is using a global mutex that is held for as long as it takes the browser process to get and build the tab list. Perhaps something similar is happening in Firefox. Try doing the whole nuke-profile-from-orbit thing, remove all extensions, reset all the settings, etc (after backing the profile up sufficiently to be able to put it all back). It might be some obscure option or configuration flag. Given the low number of tabs it's not likely to be that.
Medication doesn't work like potions in a role playing game, there are usually side effects.
It sounds to me like you're saying:

(a) WebGPU could be dangerous anyway, so why not just expose Vulkan entirely with no safety?

(b) Committee-designed APIs are always doomed to fail, equally Google/Apple/Intel's fault, they won't ever ship a non-MVP anyway, 'so why bother' I presume?

(c) Console vendors are pushing server-side rendering pixel streaming too, so we won't have any control over our devices ultimately in the future anyway - so none of this matters.

If those are the arguments, I'd rather have WebGPU than not have it, personally.
There are still instructions for binary coded decimal arithmetic in our 64-bit superscalar multicore processors (although they throw #UD in 64-bit mode).

DAA and AAA for addition,
DAS and AAS for subtraction,
AAM for multiplication,
AAD for division.

The software interrupts (INT) were almost universally replaced with SYSENTER and SYSCALL (and their SYSEXIT/SYSRET counterparts).

ENTER and LEAVE instructions for manipulating the stack for function calls are slower than direct modification of *SP and *BP.

The extra segment registers (ES, FS, and GS) are nearly useless in flat memory model (CS, DS, ES, and SS must be equal for practical purposes). Thread local storage uses FS in Linux, and the kernel uses GS for per-cpu data structures. It looks like BSD may use GS for thread local storage.
Not if those first hand accounts are known to be extremely biased. And you don't nned those books, the primary sources, war diaries, field reports and so in, are available now. No need to use, or believe, self promoting statements and books trying to whitewash (in the case of German Generals) or improve (allies) one's image.
Not if it isn't used for security
Lens Protocol – a composable and decentralized social graph
This may be fixed in the newest macOS betas. The manual for my car wasn't rendering before and now is.
The thing is, mathematics is nowadays almost the only science where someone can make a name for themselves at a young age, because they don't need as much funding (except to pay their own bills), research grants, associates to do grunt work etc. etc. So if the Fields Medal would really go to "the traditional pack", it would be especially unfair. Of course it's also unfair that many of the biologists, physicists etc. doing the grunt work for their higher-ups don't get recognized either until they manage to climb to the top, but such is life...
Apples are believable, but that does not say much about the fruits mentioned.
> Moreover, can you influence GCC over what instructions it emits? On Gentoo for example, you can setup your make file so that the while system is compiled with your specific processor in mind.

For what it's worth, this is largely unnecessary nowadays. Tuning for a specific processor used to allow the compiler to use instruction scheduling and enabled use of SSE instructions. However:

1) Modern x86 CPUs all use out-of-order execution, making instruction scheduling unnecessary. (Some older Atom CPUs are in-order, but their performance is pretty awful even with instruction scheduling.)

2) If you're building for x86_64, you can assume a certain baseline of instruction set support -- in particular, CMOV, SSE, and SSE2 instructions are always available on any 64-bit CPU. While these don't cover all instructions, it does cover the bulk of what the compiler is likely to want to generate in typical application code.
>So I'm not allowed to use words with negative connotations (or have values different than yours) lest I be deemed "set in my ways"?

It is not just a word with negative connotations. It is that you revealed your definition of the word as purely negative. Ask a person how they define "woke" and they will reveal a lot about their politics.
Pretty sure you mean "contracted" TB, but the typo did provide a humourous mental image.
The kernel either uses a separate file written in assembly (.S file) or inline assembly that GCC understands.

https://github.com/torvalds/linux/blob/ce990f1de0bc6ff3de43d...

https://github.com/torvalds/linux/blob/35e43538af8fd2cb39d58...
Fewer and less severe than obesity, in the case of semaglutide.
At the time we happily used also tools outside of VS like CVS, SVN and then later git.

Also, VS came also with TFS Version Control which was better than CVS (not much tough) or source safe.
I'm of the same opinion. I can't stand any dark roasts, as they actually upset my stomach.

But ho boy have I tried cheap American coffee. That filter coffee you get in NYC. In 3 separate places including in a 5 star hotel. I've never tasted any coffee that was so horrible.

And I'm brewing with an Aeropress for over 10 years. It's by far the simplest and most lenient way of brewing coffee, and produces excellent results. I just can't be assed to faff around with brewing methods.
You can with -march flags, but there was a long time where the added instructions weren't useful for "typical" programs, only high end ones using SIMD. So many of them still won't be generated, since autovectorization isn't all that reliable.
They should mention about it on the front page!I mean vala is looking pleasant to work with other than c++. So is there any resource to follow along? Can I create an app in macOS with vala sdk?