skysight-inc/HackerNews huggingface dataset:
This isn’t quite right — I think you’re thinking about circulating tumor cells (CTCs).

These tests on the other hand detect circulating tumor DNA (ctDNA), among other things. It is well known that tumors shed DNA and other material more than normal cells, even at early cancer stage. (Of course, later stage and more aggressive tumors are more indeed likely to shed more.) The detection limit for some of these tests is in the range of single digit copies of DNA fragment per mL of plasma.

Furthermore, the goal isn’t necessarily to detect every cancer as small as it could possibly be. Even if you don’t do a great job at finding all cancers at stage I, you may still save lives by detecting cancers at an earlier stage than they otherwise would have been found. Finding something at stage II instead of III or stage III instead of IV may well mean the difference of a shot for curative resection / radiation. (Whether these tests would be remotely cost-effective at attempting this at population scale... I leave as an exercise to the reader & healthcare system.)

Grail had a paper with some scant info on their test performance in multiple cancer types across all cancer stages. https://www.annalsofoncology.org/article/S0923-7534(21)02046...
Similar opinion here. But another reason is now I tend to write my own code rather than depend on third party libraries and that removes one argument for making a choice.
I agree in concept, in practice I find the relative frequency of "I can't quite remember that thing" is way higher than learning new things I don't know if copilot is right about.

> what will be the consequences?

for me, usually a failed build or unit test :P low stakes stuff
Why would anyone choose this over an AMD X13? At least the Linux support is relatively mature there, even the GPU driver is in mainline kernel+mesa.
That's the thing. I'm not saying "if you replaced smoking".

I'm not talking about a hypothetical comparison between smoking and vaping.

I'm talking about my original statement, and your misunderstanding of it.

My original statement was not to say that if you replace smoking with vaping. Of course vaping is less bad than smoking.

My original statement was to say that smoking nicotine is the leading cause of preventable death, so if we add in deaths by chewing and vaping thats even more deaths. That's all my original comment and subsequent replies are referring to - not a comparison of vaping vs smoking.
AI Training Should Allow Opt-Out
In some countries there are foundries and schools that do weekend classes where they walk you through the steps and already have all the necessary equipment and safety knowledge. You might see if you can sign up for one. Anything involving molten iron has a tendency to be, on the human scale, incredibly violent; as a consequence, it requires great delicacy and care.

Or you could start with pot metal or aluminum.
I have no example at hand, but if you look at "lithium battery cell balancing" you find many sources, two at random

A very generic article
https://www.saftbatteries.com/energizing-iot/lithium-ion-bat...

A thesis who cite many balancing technique
https://tel.archives-ouvertes.fr/tel-03584252/document

Another normal advise is not to charge at 100%, not because it's bad in general, the contrary it's NEEDED for a proper cell balance, but on cars have a potential issue, the very same who is an issue for the grid stabilization: when you ask for more power your battery and inverters do their best to give it, but when the demand drop, for instance because you have hit the accelerator then release it, there is an excess of power and on a battery-only system like a car you have no grid to push excess energy to nor you can shut down. As a result you divert excess back to the battery crating high DC ripple effects overheating and stressing the battery itself.

> My utility can already turn off my air conditioner during peak demand, why is it harder to turn off a 4000W load when they need more power than to turn on a 4000W battery when they need more power?

It's not an on-and-off problem but a how quick such on-and-off can happen. As I suggest try seeing your p.v. system when it works. Try see how the frequency spike constantly with p.v. inverter active and how stable is (normally) on the grid, try to se what happen when you start a big load and when it drop. To see that better, if you have lithium storage try to run exclusively on it+solar and see what happen.

AC is veeeery nice for many aspects, but it's hard for others. Try to keep a grid at a certain frequency is NOT an easy business, trying to do so with a gazillion of small generators is next to impossible.

Smartness is a modern hope we add in both regulatory capacity for generators and avoid sudden loads spikes because smarter loads can potentially advise generators before starting or stopping and eventually ramp up or down slowly. However so far we are in an uncharted territory with just very little experiments and nothing on scale.
Ben Franklin was shitposting even in the 18th century.

One of his greatest hits was a proposal to transport rattlesnakes back to Britain in exchange for the felons transported to America, "to have them carefully distributed in St. James’s Park, in the Spring-Gardens and other Places of Pleasure about London; in the Gardens of all the Nobility and Gentry throughout the Nation; but particularly in the Gardens of the Prime Ministers, the Lords of Trade and Members of Parliament; for to them we are most particularly obliged".

After living in France and observing their local custom of sleeping in as late as noon, he wrote a long, satirical letter relating his "discovery" that the sun rose in the morning. "Your readers who, with me, have never seen any signs of sunshine before noon, and seldom regarded the astronomical part of the almanac, will be as much astonished as I was, when they hear of his rising so early, and especially when I assure them, that he gives light as soon as he rises." Later on he proposes, "Every morning, as soon as the sun rises, let all the bells in every church be set ringing; and if that is not sufficient, let cannon be fired in every street, to wake the sluggards effectually, and make them open their eyes to see their true interest."

You can't tell me this guy would have been able to resist Twitter.
1920 is 100 years ago, so I don't think it's an arbitrary starting year. Also the older you start, the worst the data quality will be.
If your "going rogue" project fails, then you can be seen as not having done any work for X weeks. If your manager was against you working on that project--especially if they needed you to work on something else--then you will be seen poorly, and that can be rough for your career.
Yes there was more rare gear, like bone armor that you didn't want to be ganked.

When you died, by either monster or player, your corpse contained all your possessions. If you could get resurrected in time or you had help you could get all your stuff back.
Late detection is better? Ignorance is bliss? There is no golden path?

What if early detection failures at scale lead to better medicine? What if more patients lead to more science?

Resigning to, "fuck it, we aren't there yet" seems overly defeatist.
Same - I still like Python for scripting, and Scala is still the language I have most fun coding in, but … JavaScript got decent, and TypeScript got really good. I used to want Python in the browser, but no longer see the need.

TypeScript is just a terrific choice for basically any web SPA. My current company is full stack TS (React/TS/MobX on the web, React Native/TS/MobX on mobile, RESTful Express/TS/Postgres/Redis services), and it’s the most productive, straightforward stack I’ve ever used. Perfectly decent performance too. A single language that is legitimately a great choice for most use cases on the web, mobile and backend, hard to compete with that.
The examples are poor, but OPs analogy still stands. If e-cigs are to MJ/shrooms and regular cigs are to Heroin, thinking that e-cigs are less harmful is probably not 'deluded'
For games you often use pragmas to selectively disable optimization. It depends if you will be debugging in a few key places or not whether that is useful, but if you are manually placing logs I assume so.
All of the mistakes are in this paragraph:

> The researchers also claim that harbinger households voluntarily cluster: that when a harbinger household moves, it is likely that it will move to another habringer ZIP code (and nonhabringers move to nonhabringer households). Moreover, harbingers don't appear to learn their preferences from one another — a nonhabringer household that locates in a harbinger ZIP code doesn't alter its purchasing and political contributions to "loser" products and candidates.
For an academic journal, it doesn't feel very scholarly to presume the audience is American and that American Koreantowns are the only Koreatowns. Obviously its clarified in the article, but the title is borderline click-baity.
Good stuff, reminds me of PLT Hulk [0], although obviously Grug isn't a fan of powerful type systems.

[0] https://twitter.com/plt_hulk
Mites that mate on our faces at night face extinction threat
http://www.chinadaily.com.cn/china/2009-01/23/content_742298...

According to this article 2 people were executed, one had a "suspended death sentence" (which they say is usually changed to life in prison).
I used it a few times for great effect, many years ago, when dealing with very data heavy Swing applications. We dealt with millions of rows of data, and some keys were strings with very low cardinality. Interning some of those columns lead to major reductions in memory usage: Tens of millions of copies of the same string aren't all that great for 2005 era laptop, as headroom between garbage collections, especially back in the day, could make a big difference. Now, the fact that the strings were comparable with == vs .equals? never bothered trying to play those games.

Now, could we have solved this with other ways other than interns? Absolutely: Just make deserialization code do mostly the very same thing, but done by hand and on the heap.

In today's JVM, if you are using the G1 garbage collector, you can get 99% of the memory savings almost completely for free with a VM parameter: You still pay for an extra object, just pointed to the same character array underneath. I'd argue it's one of the most underutilized flags out there: It's not uncommon to end up with half the memory footprint in many use cases, and memory savings are often runtime savings too. Now that we have this, maybe intern always loses, but it was definitely useful in the right circumstances.
Nivea sensitive shaving cream? In the squeeze tube?

I used to care about such things. Then I just embraced the inescapable endless change, and started using soap.

If you wet your hair first, then put on the soap, I find it not too bad.

Just embrace it. Because they just keep changing stuff.
Here's a list I was given on another thread

https://git.sdf.org/humanacollaborator/humanacollabora/src/b...
Definitely don’t read the leading Sociology, Economics or Political Science journals then. That’s completely standard.
Or TkInter and PyQt, which exist since 2 decades ago if not more.
Not accusing you, however I'm using this comment to note a trend.

> authoritarianism is not a good idea in general.

I hear people say this a lot, then a celebrity says something mean on twitter and suddenly the same people are up in arms about the perils of free speech and someone must be legislated to right this wrong.
again, people already accomplish exactly this thing by posting screenshots of text. but that's less accessible, less searchable, and an overall poorer experience than letting people post actual text instead of screenshotting it first.

and if you don't personally use twitter, i'm not sure how qualified you are to judge whether or not something defeats the purpose of twitter.
Or, we were paying close attention and saw the rise of fake-branded carts absolutely exploding on social media right before popcorn lung cases hit the news. And for 3-4 weeks there were all these god damn stories and all these theories even here on HN.

But many of us, watching the sidelines in /r/fakecarts or whatever the various subs are that I used to check in on, were reading countless stories of "friend drives these from Cali bro, but my friend had to go to the hospital". Over and over, right before they started hitting the national news. Oh, and by this time the cannabis forums were already abuzz trying to figure out what the "new" suspension liquid was. And worried that it was Mineral Oil or Vit E oil. Which, it was.

And then there were 2-3 big fake cart producers busted in the Midwest, the new product was removed (never followed up to see if he was held liable) .... And just like that "popcorn lung" stories fell out of the news. Damn near immediately (I remember this hyper distinctively as I'd done months of research about everything concentrate/cart related before a large travel trip. Before I left I was watching fake carts explode. While traveling I was laughing as people were indicting pot, all carts, vapes in general. And then sure enough, a few arrests were made in the Midwest and I've literally never seen a noteworthy article about "vape popcorn lung".)

I am absolutely aghast at some ignorant, half-truths repeated up and down this thread. People that fell for FUD and assume their historical memories are correct. People acting like a well-regulated mod is a, I quote, "pipe bomb".

I swear, some folks act like because it's "drugs", there can't be objective information. Or are just so willing to be swept away with boogey man bullshit if it touches up against some societal "rule" built into them. And then the smugness of "well, duh, of course" based on an incomplete understanding of the situation.

---

Bah humbug -- the real only answer that matters is -- buy an e-rig, have discipline, take baby dabs. Your money will literally go twice as far, zero risk of heavy metals, no bullshit additives if you're buying wax/live-resin, at least in Washington.
Not as much as we expected frankly and each new nodes is as quick to setup as Tailscale I’d say.

The main « issue » was working with some key concepts of Teleport (logins, roles, connectors).
I think “code” is already at the right layer of abstraction. “Code” already solves this problem and has the curve the author’s looking for. “No-code” is a simple case of the wrong abstraction.
How is doing nothing being compliant?

As for spending $800, how is spending $37,000 more feasible?

I find these sorts of exchanges astonishing. A 1Tb drive can be bought for $30 on ebay. Backing up to it is a simple xcopy or rsync command. Then put the drive in the safe.

It's as simple as that.
Funny no one on HN talks about Unqork
This is true, it cashes out the carried interest as well, so if the new fund closes with a lower valuation for that investment, the investor was screwed out of more carried interest than should have been paid.
>Trans. Secretary Pete Buttigieg recently recommended that people struggling with gas buy an electric car

I got a hybrid, which were discounted when nobody wanted them when gas prices were in the toilet in late 2020.

A non-plug-in hybrid that gets 40-50 mpg is (or was just before the current car shortage) the most economic option according to my best calculations. Once I tried to estimate the fossil fuels that go into food and stuff and found riding a bicycle is not a lot better or worse than a 50 mpg car with one person in it.

Everybody seems to have an excuse for doing something else though. I have to admit that it took me years before I followed my own logic, but I finally did (because I found something I liked better than a Prius with similar mpg).

A non-plugin hybrid has 1% of the electric range, so I don't think the difference in battery size vs. a full electric is unimportant. Batteries get better, but the ratio, not so much.
I've been buying normal fit jeans from Costco for all of $16 a pair for the last two decades. Dad jeans, I suppose. No care! Love the jeans, they're built a lot better than my last pair of brand name jeans.
So maybe “no code” tools should be thought of as photoshop for software.
Because if you are an IoT service with one human and 100,000 devices, the amount of support you may need is more dependent on the 100,000 than on the 1. Very large numbers of devices per human need somewhat different pricing.
I went off on a tangent and found out about the EVICT transaction type in XTDB, which removes data from the logs which are otherwise immutable.

For some reason this GDPR compliant feature just makes me angry. It's so... so.... crufty!

Is it just me? I'd really like to know why this angers me so much? I'd like to be able to know my data was purged, but still.... arrggghhhh
Azure DevOps. It's a terrible name and kind of a weird marriage of Jira and Github Enterprise, but the solid integration between work items, PRs, and CI has grown on me since I've been forced to use it. There's a managed option, but you can self-hosted, too.
Same. There's something fun about optical disks.
How does that work for numpy or scipy? A main point of using python is the ecosystem.
> Is there actually anything different about python here?

I say this as a big fan of Python: I think the main difference is that the CPython C APIs are much more of a pain to use :-)

I don't know about Node's C APIs, but I've written both Python and Ruby extensions and find the MRI APIs much nicer than the CPython ones.
RunUO and trying to make custom scripts as a young teen is what got me into programming so I guess I can think Ultima Online for my career.
It's all abstractions. Python code is no-C-code. C code is no-assembly-code. And so on...
So maybe “code” is already at the right level of abstraction and not everyone needs to be a doctor or lawyer or pro football player.
https://internettepat.telkomsel.com/asset/Banner-Internet-Po...

This site cannot be accessed because it might contain pornography, gambling, ..etc
I did the first part in F#, and rather than translating Java to F#, I looked at what the author was trying to accomplish in each step, and did something functionally equivalent in idiomatic F#. That was fun & challenging.

haven't tackled the second part, I'm currently down the rabbit hole with Samuel Mimram's Program = Proof, which I'm just loving and the first book I've seen that focuses on the Curry Howard Isomorphism, covering essential logic, lambda calculus, type theory, and Agda... so good.
But that's kind of not the issue here.

It's that false positives in the cancer detection process can sometimes be more likely to kill you than if you didn't check for cancer in the first place.

And of course all the flow on effects where the cost of detecting cancer and doing all of these exploratory surgeries means you spend less money on food, well being, basic medical care, dental care etc. Which then may kill you faster than just living with the cancer.
LPs are usually pension plans, endowments, or family offices. The stewards of these have different incentives than the ones that are tied to the capital.
I don't see these sorts of claims as falsifiable.
What about the "wife murderer" aspect?

How do you get over the `eww' factor?
I've actually heard the opposite anecdotally so i looked it up.

In this study 57% out of 1000 persons seeking treatment for drug and alcohol dependencies said that quitting smoking was harder than their problem substance.

https://jamanetwork.com/journals/jama/article-abstract/37628...

From this article:
'Heroin addicts say it is easier to give up dope than it is to give up smoking,'' says Dr. Sharon Hall, a psychology professor

https://www.nytimes.com/1987/03/29/magazine/nicotine-harder-...

I dont have personal experience with opiates, but do with nicotine and I can say it took 10-15 years before I didn't have a regular desire to consume nicotine. It was the hardest thing I've ever done.
python's async mostly works as long as you're using async-native libraries. if you can await it, it's okay. it only gets disastrous when you have to start mangling callback code into promises.

although i really do love javascript's ability to await synchronous functions without it causing any errors. i'm sure it's less performant, but sometimes i just don't care.
I've been journaling for 6 years
Isn’t this concept originally from C#? (Where interning is the default behavior)
Gotta love HN hand-wringing about THC. I've done stupid amounts of research on this. I own multiple dab rigs, multiple Volcanos, multiple DTv4, went through .... lots of carts during 2020, etc.

If you are looking to consume concentrate, the solution is quite easy - get an electronic dab rig, take baby dabs. It's the same thing as "vaping" from a cart, but there's no heavy metals, and at least in WA, the quality of raw concentrates is very high. Not as portable as a pen, but also I'm not really trying to be stoned all the time or in public anyway.
Build Spreadsheet Features - Like an importer, REST API etc
We created developer tools for spreadsheets.
Create a spreadsheets importer. Use your spreadsheets as an API. Set up auto reporting for your team. All within minutes.
Thanks. Going through the docs now.

https://www.vaultproject.io/docs/concepts/seal#shamir-seals

Shamir seals
The default Vault config uses a Shamir seal. Instead of distributing the unseal key as a single key to an operator, Vault uses an algorithm known as Shamir's Secret Sharing to split the key into shards.
> Hopefully written elegantly and carefully, with lots of thought for future maintenance and readability.

Those are fine things to value even if they are highly subjective.

You might think it’s easier to read a while loop with a handful of mutating variables and a few branches. I might disagree.

I think it’s easier to read an accumulating function that uses traverse.

It’s wishful thinking that we should both hold the same values or that only one of us is right.

> big brain type system shaman often say type correctness main point type system, but grug note big brain type system shaman not often ship code. grug suppose code never shipped is correct, in some sense, but not really what grug mean when say correct!

This big brain ships code every day.

Also streams big brain work in big brain language once a week to show people that it’s not the work of big brain shamans.

Big brain is happy to answer questions and help people learn.
Definitely saving that, translating it to interview-compatible speak, and springing it on future employers.

Actually I need to translate a good 75% of grug's teachings to interview compatible language...
>over four years ago after 30 odd years of smoking around 20+ a day.

This guy is clearly older (lets say he started smoking at 15, we would be pushing 45 as a lower bound), and he's not American where that word was common slang. I think there's a place to consider intent and realize that this is the internet, and not everyone is an American 20-something.
A true “Greenhouse Earth” would be enormous change
But the other question is whether the endgame is prevention or treatment at all.

Are some types of cancer better treated like HIV/AIDS where it's simply managed.
Can family offices, idk maybe one with a big Roth IRA, lever this?
> not the best thing for those that write

I disagree. I think this is mostly meant to steal market share from other walled-gardens such as Medium. People who write on self-hosted blogs and the like will continue to do so.