skysight-inc/HackerNews huggingface dataset:
> those figures are very very heavily massaged in multiple ways

One person complains they don't account for taxes and benefits, and another complains they do!
> Unless you are literally having someone else do the assignment for you entirely

I've seen stories on HN about one person showing up for an interview and another for the first day of work.

But it doesn't matter so much if it's an urban myth, if the people involved in the hiring process imagine elaborate scams can happen.
Sorry, we reached our cost limit for messages. It seems like someone used a bot or something to message it for a long time. It spent $120 before it shut down.

It'll refresh each month, and I'll probably add a better explanation so it's more clear what happened.
Carbon-Aware Core SDK
It is easy to discount the amyloid hypothesis and amyloid research based on the facts that 1) amyloid is not required for neurodegenerative disease pathology, 2) many people who do harbor amyloid fibrils/protein plaques do not exhibit neurodegenerative disease pathology, and 3) amyloid-reducing drugs do not seem to affect neurodegenerative disease progression. It is also true that amyloid is an enticing target for a lot of people with vested interests in this area and those interest may have put too much emphasis on amyloid itself. Like most things in biology though, there is more to the story.

Consideration 1: Amyloid itself is a structural characterization of protein assemblies. Amyloid structures generally form in intrinsically disordered (ie unfolded under normal conditions) proteins as a low-energy conformation that is self-templating and derives its stability from a large number of interactions between many copies of the same protein. Amyloid is not really related to protein function in a direct way. The biological roles of disease-associated amyloid-prone proteins (some famous ones are Aβ, Tau, and TDP-43) can be quite varied in the non-amyloid state. These proteins are also associated with neurodegenerative disease through orthogonal means, namely through genetic analysis of disease-related mutations, so it isn't just the fact that these protiens wind up in amyloid fibers that leads us to believe that they're associated with neurodegenerative disease. So, we know because of genetic analysis that these proteins are associated with disease, they can all form amyloid, but we aren't losing any consistent biological function due to their dysregulation–this strongly suggests that the amyloid or otherwise dysregualted state of these proteins is problematic on its own.

Consideration 2: Recent structural work has tied different amyloid isoforms to different disease pathologies. I work in an adjacent field to this and these results were really what changed my mind about the validity of the amyloid hypothesis despite years of doubting/discounting it (often in a public way, often to the detriment of my own career–turning the corner on this was a bit challenging). See this paper and the first 5 citations in it (https://www.nature.com/articles/s41586-021-03911-7) for a good example of direct structural links between amyloid structure and disease pathology, and the associated comment (https://www.nature.com/articles/d41586-021-02611-6) for a good overview.

Consideration 3: The presence of amyloid plaques in patients in the real world is generally assessed by histological analysis or other methods that don't capture information at the molecular level. This, combined with the two points above that seem to point to some shared structural features of amyloid-prone proteins being disease causative, suggests to me that studying amyloid (or maybe more specifically the behavior of amyloid-prone proteins) is still a worthwhile endeavor.
They may be bought by someone bigger and then shutdown to protect the existing wild gardens. There are many analogies. Astrid[0][1] and Wunderlist[2] come to my mind.

[0] https://en.wikipedia.org/wiki/Astrid_(application)

[1] https://github.com/tasks/tasks

[2] https://en.wikipedia.org/wiki/Wunderlist
Deno is only possible because V8 is so hyper-optimized. If you think about it, V8 has to compile/interpret and then run javascript code on the fly after downloading it in the browser. That's how good V8 is. That puts javascript in a unique position to enable something like Deno

So if there was a compiler/interpreter for another language that was close to being as good as V8, then something like this could exist for other languages.

Also, it looks like wasm works on Deno, so that gives some other languages.
I've seen you make a whole lot of posts now

So far, you haven't named a single thing we couldn't already do vastly better
Install mods and play custom songs. They're 100% better mapped and you have endless choices.
I'm glad I wasn't the only one who struggled a bit with the triple negative.
that's why it's called copilot and not autopilot
> top money

I'd contract several candiates from truelancer to do a small task each, then evaluate which is the best one and contract him/her again to work on a milestone.
There'd be a good portion of California that was very suited to home solar: remote, sparse, sunny, little shading. I wonder if they could incentivise some areas to do away with power cables by subsidising solar and home batteries? Or somehow minimise the powerlines required?
It appears to be the opinion of the market.

Where are the indications? There are dozens of services using something like this, none of them have gone mainstream in the 50 (maybe 25 from a practical perspective?) years it's been possible.
> Is "this website" all of the web?

Do I actually have to answer this?

.

> Good God, can we please stop with the cheap rhetoric and at least try to discuss things in a productive way?

I didn't engage in any rhetoric.

The question I asked you remains unanswered, and I was in fact being productive.

Sorry you got stuck. Better luck next time I guess
This explanation resonates with me.

I first saw Ryan Dahl's talk about his Node.js regrets[0] during the early days of the pandemic. I thought I'd be eager to try Deno when it became more mature, but I still haven't tried it. I guess I'm not convinced that it's 10x better than Node.js.

[0] https://youtu.be/M3BM9TB-8yA
Yes they actually document which bit is what

> Get the source element type of the given GEP operator

Notice the relentness repetition that provides precision and clarity? I now know the argument GEP is a GEP operator. Might seem redundant, but it allows a new reader to start from any point and find their way to the relevant terms / nouns and their types.
https://edition.cnn.com/2021/11/05/politics/ed-durr-steve-sw...
It's a battle of ideals, you could have have a high entropy ecosystem that's constantly evolving and perhaps "appears" unstable, or an ecosystem that's "gotten it's shit together" and probably trends toward stagnation and apathy
To emerging markets like latam, a "pluggable hybrid" that can make 80/100 km with battery power , that could be recharged with a common household and and with a pricePoint not too far of a similar ICE makes more sense than a completely electric car (at least until batteries get really affordable)
Who gets paid before working? I haven't seen that at least here in the states I've worked in the US. Usually you work to the pay period and receive the prorated amount of days you worked. Sometimes you even have to work for two pay periods which can equate to misery if you haven't saved up. lol.

Edit: I reread your comment and understand now! Sorry about that.
It's worse this time, in that the old shared hosting environments (e.g. Apache with FastCGI and suexec, or nginx with fpm) were open source, and there were countless shared hosts. The new generation of multi-tenant isolate-based JS runtimes are proprietary, and AFAIK one can count the number of hosts on one hand.
Definitely Go, you can crank out stuff with it over a long weekend or a few hours a night for a week. You won't be a senior Go programmer but if you know another language, you'll pick it up quickly. You will not pick up Rust and Julia quickly (as compared to go) :) .
Microsoft will phase out facial recognition AI that could detect emotions
1-2 are facts, sure. What proof is there that the TITO actually is a Chinese car? Your statements hinge on that assumption.
> > But the real key is the fight against crap: you sell a mixer with a plastic gear, easy to speculate that will break after few year, ok, you are allowed to do so, but you get a progressive tax: as much as durable and repairable is your device you pay less. For a mixer that means: 30% of the sale price as tax if it's expected lifetime is less than 10 years of normal usage.

> So the cheaper mixer is now as expensive as the better built one. This means there's no more cheap mixer on the market. How is getting a single mother of three to pay 30% extra taxes to fund some civil servant's pension fund helping anyone?

Is it better to have an invisible "poor tax" that makes your single mother spend 2-3x the price of the cheap one over 10 years since it breaks so much faster instead of having to save up longer initially for the one that probably won't break in ten years?

Could do an escrow/deposit style thing so you can get your money back if your cheap shit actually doesn't break faster. So there's an incentive to make things cheaper only if you are confident in your long-term business model and reliability.
No they don't, unless you use their website.
Most people don't have a secure place to plug in.
Brightness adjustment from desktop is great! For anyone else on Ubuntu I use this gnome plugin:

https://extensions.gnome.org/extension/2645/brightness-contr...
Has anyone actually verified it's the same car? They only mildly resemble eachother IMO.

That said, Coradir's site seems to be a lot of rebranded gadgets so it wouldn't surprise me, but I haven't seen any actual proof of this, just speculation based on cars looking similar.
It would be super convenient to avoid having a mess of cables and a switch behind your TV, or having to use Wi-Fi, that has its limitations, especially these days with higher and higher bitrates.
Ugh. Permaculture might have biosphere balance as a secondary effect, but the idea and focus of effort is about allowing natural processes to perform the maintenance for you. It is about using living machinery to automate the process. It jives well with sustainability, and that's fantastic, but that's not the focus. The focus is on the efficient production of useful goods in ways that require minimal maintenance by letting other creatures do all the work for you.

How exactly do you do computation in that way? There are ways, I'm sure. But not with anything resembling computers we use today. You'd basically need living computers. I'd love that, but I am not a fan of this rebranding of the term "permaculture" to shoehorn silicon into the sustainability movement, it doesn't fit, unfortunately.
It might also be the sagging lines methinks.
This comes with a major caveat.

Your DNS host needs to support being able to assign a CNAME record on your root domain to a domain provided by Cloudflare. AWS Route 53 does not let you do this which I imagine is a decent chunk of enterprise clients. AWS only lets you alias records to AWS resources not external domains.

With that said, even with enterprise in this case you would need to go all-in with Cloudlfare's nameservers or run the risk of not having DDoS protection on your root domain (ie. example.com wouldn't be protected but you could protect www.example.com since a CNAME with subdomains is a standard thing).

However it's kind of interesting because an attacker could get the real IP of your root domain's AWS load balancer which is probably the same load balancer used for the `www` version of your site too, but now that they know your load balancer's IP they can completely bypass Cloudflare and go straight to your infrastructure.

I'm pretty sure AWS doesn't let you assign an external domain with their aliases because they want you to pay them for AWS Shield Advanced instead of using Cloudflare because AWS knows getting an enterprise client to change their nameservers and all of their DNS records (potentially dozens of domains and multiple hundreds of records) is kind of a pain. It can be done but it's a friction point.
You're right, my advice may be biased. I work on physical systems operating under tight control and near equilibrium most of the time.
I’ve noticed something similar at the company I work for and I think I have an explanation. Basically, upper management doesn’t understand what it takes to accomplish tasks anymore due to maligned incentives from middle management. Middle management wants to progress up the corporate ladder, which it does by growing its team size. E.g. by growing a team of 10 into a team of 100 with new layers of management below. This happens even if the scope of work remains largely unchanged. As a result, no one knows how many people it takes to accomplish tasks. There are so many people that ownership becomes and issue. People can simply pass the buck. And any sense of autonomy fades as more people are brought on to do a dwindling pool of actual work. The end result is large, inefficiently run bureaucracies.
This is old, does not include Biogen's drug.
I agree. I'm not sure how it at other companies. Both at my current company and previous one, line managers had a misc budget of $2000 before needing oversight, with bigger numbers as you went up the leadership chain, but I never interacted with those types frequently enough to ask.

This was for one time purchases only. Recurring charges i.e. SaaS offerings would need to go up to the division head for approval, which means effectively no unless it was essential stuff like Jira/Bitbucket, Office, etc.
Same reason Larry and Serg left. Avoid the hassle.
A lot of contractors in painting/drywall do piecework rather than hourly. My roommate has been a drywall taper for 20+ years. When he quotes a job it’s a flat rate and then he tries to finish as fast as possible by using his best tools to speed up the job. On the other hand, if someone hires him on an hourly basis he puts away those fancy tools and does a lot more manual work, getting the job done slowly.

His rationale: why put wear and tear on his expensive tools if it’s just going to reduce his income in the end? Needless to say he prefers piecework because he likes to move from one job to the next as quickly as he can. He makes a lot more money that way.
Does durability get any rating?

Lawn mowers made from plastic parts can get ratings ~9 out of 10. Interesting because plastic wheels and plastic cowlings etcetera get broken, there is a commitment to replacements but how long before they disappear. . . The index doesn’t seem to contain any metrics for: hardiness, fault tolerance, reliability, toughness, or general ability to avoid breakage in the first place.

For foreigners: French numbers 7,1 means 7.1

Here’s a translation of some of the ratings - I think it is out of date - unfortunately most of the docs I Googled were PDF and I couldn’t be arsed dealing with PDF.

Criterion 1: Documentation
Sub-criterion 1.1: Availability of documentation
Sub-criterion 1.2: Instructions for use of product maintenance and updating tips

Criterion 2: Disassembly and reassembly
Sub-criterion 2.1: Ease of disassembly and reassembly (breakdown/breakage parts)
Sub-criterion 2.2: Tools required (breakdown/breakage parts)

Criterion 3: Availability of spare parts
Sub-criterion 3.1.1: Commitment to the duration of availability (breakdown/breakage parts)
Sub-criterion 3.1.2: Commitment to availability (functional parts)
Sub-criterion 3.2.1: Commitment over the delivery period (breakdown/breakage parts)
Sub-criterion 3.2.2: Commitment over the delivery period (functional parts)

Criterion 4: Price
Ratio/price of the most expensive part (breakdown/breakage parts) to the price of the new product

Criterion 5: Specific criterion

In French (pardon the fucking image, sorry, WTF is going on with unpardonable French results? Fuck accessibility huh?): https://www.indicereparabilite.fr/produit/tondeuse-a-gazon-s...
Might be that birds have been getting electrocuted throughout that period, but the areas being dry enough to support/spread fire have grown?
So many butthurt landlords over there in the comments decrying "breakdown of property rights" and such nonsense.

Well yes, it sucks to not be able to turn a profit without any productive activity anymore. Hope this'll catch on everywhere!
Is copilot then not teaching you bad habits that you can't see due to lack of familiarity? Is that a good thing?

The idea of learning via copilot, producing poor code and having copilot learn from that code ... the whole feedback loop ... Is worrisome.
The only really promising treatment effect I have seen in recent years was in a huge, broad study of Veterans Administration patients (N tens of thousands) conducted over a 6-year data set.

What they found was that having had a Tdap vaccination booster recently predicted a 40% reduction in dementia risk.

They then replicated the result with a wholly disjoint population treated in a different system.

40% effect is better than aspirin for headaches. A confounding factor with that much correlation would be almost equally interesting even without causative effect. I don't know of anything else that predicts dementia risk.

They had no idea which component of the Tdap vaccine might be responsible. But you can bet I went out and got my Tdap booster right away. Because why not?
there was a trend in neuropsychiatry to study "neuroendophenotypes" - the smallest behavioral changes linked to gene expression - rather than treat macro-level diagnoses like autism as monoliths.

autism probably covers hundreds of discrete genetic disorders that share similar pathology. for instance, Rett syndrome is sometimes considered part of ASD, but only explains a small number of ASD diagnoses.

I don't think that precludes ASD from being a useful diagnostic category, though. behavioral therapists don't need to know your genotype to help you cope with sensory overload. schizophrenia probably works the same way, but you still prescribe antipsychotics regardless.
Another downside would be people who know the existing symbols having to learn the new ones.
I’ve got a Samsung frame… and you need the net to get the picture screen going … ! Which I quite like as a feature. Even though I put all our digital tv through an Apple TV.
Exactly, and I feel like that's subconsiously the point of setting a goal like that. It's unattainable, so by conflating it with weight loss in general, of course weight loss isn't possible, which is a sentiment you will see repeated quite frequently in any online weight loss discussion.

My max. sustainable weight loss rate seems to be about half a kilo a week. Any more and I start yoyo-ing.
How fish got on land, and stayed there. Maybe.
Like the indian tata nano, it won't sell in US and EU because it won't pass safety regulations.
surely moving away from being ad or affiliate driven would create more trust?
I thought that my attempts were countless, but when I actually had to fix it due to a psychological disorder, persistence and body scan method made their job in just a week or so.

Also tried melatonin, mostly out of curiosity - it clearly sedates, but doesn’t make me sleep. Tried common recipes like food, light, bed regimes, exercise, etc. Didn’t make a notable difference. I think these are for people with a mild or a specific type of insomnia/lag or maybe with a completely unhealthy habit.

Right temperature helped, good air too. Less stress helped, specifically I learned to say “fuck all that” at the end of the workday and to not bring it home. Not moving in bed after finding a comfortable position helped. (If you have to, move very slowly, that doesn’t “reset” the process).

When I want to not revert to 3 am, I just don’t. Everyday a reminder reminds me to go sleep and I do. My rhythms align in a couple months, but hacks work as well.
> I wonder how you decided that.

It's impossible for there to be an objective good or evil. As soon as there are no humans, then there is no good or evil, because it was subjective judgement, our emotions, all along, evolved to help us cooperate. Now, if it's not objective, then we know that people claiming it to be are either deluded or doing so in order to make their own will the norm (which philosophers love to do.)

> loving kindness, metta, the Golden Rule, and a host of others.

This confounds good and evil with ethics itself. Things like the Golden Rule, for example, can be deduced logically to generally be in all of our interests. As I said in my original comment, ethics can be reconstructed without superstition.

> If the concept exists for dominance alone, why do these religions and philosophers discuss it so much?

Obviously to get people to do what they wanted and that's exactly how it was always used by religious institutions which subsisted as parasites more often than not.
I think it's similar to many critiques of crypto: It doesn't need to exist. But someone really wants it to regardless.
Depends on their services? Wikipedia serves static sites. Their hosting costs are 3 million a year according to their accountants. They have no real recommendation engine, or really dynamic content at all. 100% of their content is free for them. They can easily store their entire site in ram on a small cluster. Given that I'd say 10-30 million would be reasonable.
the investigators narrowing the search for causes honestly believe in what they're doing.

Basically, don't blindly trust science, because science isn't just some imagined ideal of objective research. It is fund raising, reputation, ladder climbing, ego, dogma, etc...
So crypto is going to be a giant success?
Neat! I guess it got fixed in the, uh, decade or so since I last tried
Strava is great, use it all the time. This particular issue has happened before: https://www.theguardian.com/world/2018/jan/28/fitness-tracki...
Unless you are defending from the NSA or something like that, I don't think anyone has the resources to do that kind of attack, even if in theory it's possible.

Also, if you have that level of paranoia, you probably don't invite people to present in your office.

Yes, leaving around a USB drive would be easier, would also be easier to attach something to the first network port you can find, or attack some weak target in the network (for example, ask to use the printer to print something, and install something on them, printers are super vulnerable and the firmware gets never updated, also because the company that manages the printers is usually an external company with little knowledge about informatics in general).
These companies want to run age verification for every site in the UK.
> But obviously measurement is not actually done at the most penetrating particle size, because retention at that size would be indistinguishable from zero. [...] If the MPPS is given... what is it?

I'm not entirely sure what you mean. Retention is a U shaped curve, with the local minima (aka the MPPS) around (as near as I can google), the 0.2 to 0.3 micron range. As a practical matter, because the MPPS seems to not vary much between filters, and is always quite close (although apparently always slightly smaller than the 0.3 micron US standard?) nobody really seems to stress about the exact MPPS size, and it doesn't seem to ever really be reported.

(Implicitly this entire discussion is taking place in the context of airborne particulates. Obviouslly no air filter is going to work very well against, say, gamma radiation. Or a car.)

Which does mean it is possible that you could have a filter that doesn't qualify as HEPA under the EU standard if, say, it hits 99.94% at a MPPS of 0.2 microns, but does qualify as HEPA under the US standard (if it hits 99.97% at 0.3 microns). Or conversely, it could hit 99.95% at an MPPS of 0.25 microns (thus being HEPA by the EU standard), but only 99.96% at 0.3 microns (thus not being HEPA by the US standard).

Which is interesting, except when you calculate the math as applied to actually filtering room air, they're all going to be effectively identical.