"Please including at least a few sentences that precisely describe the differences in the structure and chemistry of what you call the "Wuhan 2019 spike" compared to the Omicron spike protein."

Huh, OK. Odd question though. Isn't this widely covered in the press?

The vaccines code for the spike protein lifted from the original 2019 RNA sequencing reported by China. They were never adapted, all boosters are just more of the original. Omicron is highly mutated compared to both the 2019 strain and Delta. It has something like 40-odd mutations in the spike alone.

Above you claim these are "allegations" but that's really weird. These are well known facts disputed by nobody, as far as I know. It's not some anti-vax talking point. Go read the documents submitted to regulators if you like. The chemistry of the mRNA vaccines is public, there's a good explanation of the microbiology here:

https://berthub.eu/articles/posts/reverse-engineering-source...

"Do you think differences in spike protein structure and chemistry have implications for immune system modulation via signaling molecules? If so, which signaling molecules and which cell lines?"

Well, this feels like a hostile question but whatever, I'll roll with it. At least you're engaging, which is better than most people with stars in their eyes about these things.

Omicron is materially different in ways that make the vaccines ineffective. This is one of at least three known reasons why case numbers in 2022 are much higher than in 2021/2020 despite everyone having taken a vaccine marketed as 95% effective. The three reasons (that I know of) are:

1. Antibodies to Wuhan spike fail to dock properly to Omicron spike, but the vaccine trains us to produce Wuhan spike.

https://www.science.org/doi/full/10.1126/science.abn7760

(this paper also describes the mutations saying there are 37 but the numbers I've seen vary, not sure why)

2. The 95% effectiveness number was most likely never true, as the trials had at least (a) design errors that were guaranteed to create the appearance of effectiveness in literally any substance (even water), and (b) trial fraud which is now only coming to light, in particular for Pfizer at the Argentina site.

3. The vaccines are triggering something called OAS, which is a form of imprinting. Immune systems repeatedly exposed to the vaccine over-train and start producing antibodies to the Wuhan-2019 spike even when challenged with Omicron, delaying the bodies initial response and meaning that people can get repeatedly sick with Omicron, over and over, without building proper immunity. The memory subsystem of the immune system just doesn't seem 100% precise, or maybe it's not meant to be, but whatever the reason it's been proven during the Moderna Omicron vaccine trials that this has happened (previously vaccinated people produced the wrong antibodies when injected with Omicron vaccine, which has delayed approval). This effect has been known about for decades but is poorly understood, and the risk of creating it simply wasn't considered during vaccine design or rollout.

So whilst that's not an explanation at the level of individual signalling molecules, it is an explanation in terms of immune system biology. Hope that satisfies.