skysight-inc/HackerNews huggingface dataset:
Under current rules and market structure it’s probably impossible to make a profit on mRNA vaccines.

> We analyze the financial performance of a hypothetical portfolio of 120 mRNA vaccine candidates in the preclinical stage targeting 11 emerging infectious diseases. We calibrate the simulation parameters with input from domain experts in mRNA technology and an extensive literature review. We find that the portfolio generates an average annualized return on investment of –6.0% per annum and a net present value of –$9.5 billion, despite the scientific advantages of mRNA technology and the financial benefits of diversification. Clinical trial costs account for 94% of the total investment, with manufacturing costs accounting for only 6%. Sensitivity analysis reveals that the most important factor determining financial performance is the price per dose, while the increased probability of success due to mRNA technology, adjusting the size of the portfolio, and the possibility of conducting human challenge trials do not significantly improve financial performance. These results underscore that if the goal is to create a sustainable business model and robust global vaccine ecosystem, continued collaboration between government agencies and the private sector is likely to be necessary.
I think a lot of Firefox extensions are still broken on mobile. For example, I can't find a single tab manager / session manager that works on mobile
Got it. Now, it makes sense.
It’s in C++ now. The weird spacing and functions ending in _p are Lispisms.

It’s also garbage collected so it’s still not “normal” C++ but neither is LLVM.

Not sure about the plugin API, but C++ is basically impossible to use with plugins because it’s so hard to keep ABI contracts, so it might not have changed.
You might be interested in previous submissions:

https://news.ycombinator.com/item?id=31714499 : 31 comments

https://news.ycombinator.com/item?id=31714353 : 3 comments

https://news.ycombinator.com/item?id=31711337 : 7 comments

https://news.ycombinator.com/item?id=31705532 : 2 comments
Psssj, many companies solely organise them to give those that need a place to cent a place to vent.
Well, to address the costs issue, you could run hot-hot and have half of your resources on each provider, and in the event of failure, scale the functioning one up to meet demand. That's obviously a decent amount of effort to set up, though.
I generally agree with your sentiment.

Resuming economic activity after shut downs (and the habits the shut downs changed) is taking time. There is no obvious natural experiment to tease out how much is caused by CB interest rates and how much is fiscal policy. Most of the countries that did one also did the other.

Also, data points on these issues are gathered monthly (if that often), so current analysis will miss a lot in the “fog of war” until there is more data to analyze.
Also never heard of this. Source?
Angry mobs are a signal of humans being stupid pack animals. It's sheer luck if they coalesce around a good cause.
They're the same thing
If it's something that takes me 10 seconds and doesn't make anything worse then I just update the code.

If it's something that will make stuff worse - I will explain why we should not do it.

If it's a comment about formatting the code, I would add a linter/prettier that will check/format the code automatically. If your colleague wants to have different rules, they can update the formatter config.
One^WSeveral of these chickens are not like the others.
https://archive.ph/CULkJ
Perelandra (the second book in the "Space Trilogy") by C. S. Lewis is probably the most impactful book I've read in recent years. I read it once when I was in my early teens and it made no sense and was quite the slog, and I certainly didn't understand the underlying concepts at the time.

Re-reading it in my late 30s blew my mind. I wish I had the words to describe why. Best I can do is that it solidified (dare I say explained) many of the spiritual aspects I have been struggling with lately.
eBay? "Floppy drive Lot"
PA Yeomans, the 'other' father of permaculture, had a checklist he called the Scale of Permanence. It's a sort of priority list for irreversible decisions, and is helpful for figuring out if you're expending energy on something that's easy to change later, or rashly deciding on something that is going to be difficult or infeasible to change later.

In a system that favors watching first and acting at the last responsible moment, this is in someways both a counterweight and an anchor for analysis.

There are some ways in which systems thinking is the same no matter what domain you're looking at, and to some extent the ways in which they are different have more to do with lack/lag in cross-domain communication rather than any intrinsic distinctions between the domains. There is probably a Scale of Permanence for creating a business, it's just not called that or nobody has compiled a canonical list from the available sources.
The vast majority of Electrify America charging stations are in Walmart and Target parking lots. They are positioning themselves for that role already. When I take a road trip in my electric car, it can feel like a tour of Wal-Marts across America.
We can and do limit actual donations and gifts direct to elected officials. Or at least have laws about transparency. Certainly more to be done here, but the margins of the debate are usually around things like media spending.

So, yes, you can buy an ad, or host a rally, or a fundraiser for a city-council candidate, to persuade the city council to raise the speed limit, or make parking free or whatever caused you to get a ticket. You can even schedule a direct meeting, or maybe even take out a representative for a meal to express your concern. The later case might involve some kind of disclosure, but you can probably do it.
Yep. We have a Window Server 2022 VM for testing sites in IE11 (we're in a Microsoft partnership thing so we need IE11 support) and after some recent updates it's been a pain in the ass to use IE even on purpose. Happy to not need it anymore.
Things change. People pour capital into small businesses all the time only to have them fail. If a company is able to run for a time until facts change and their business is no longer viable then that's a very similar thing. Having your business fail sucks, no question. But generally I don't think we need to compensate every failed business. I don't see why it matters if the business failed after running for 6 months vs 60 years.

I definitely sympathize and maybe there's some other use they can get out of their investment but that's a business problem for them to solve.
The Most Satisfying Checkbox
He's linked it here: https://devblogs.microsoft.com/oldnewthing/20190913-00/?p=10.... Its a good read. The LE format, especially with UUID 7 like UUID (seq UUID's), seems to be easier/faster to sort just using binary sorting on LE architectures which is most computers nowdays. Interesting to see all these tradeoffs.
My team literally do this all the time. Python for everything, Rust for the places where it doesn't keep up.
Unusual points of view.

High, low, inside a pipe, from a tree, under water, where people don't usually go / aren't allowed / can't access, etc.

Keep in mind that the unusual can become commonplace if overused. Selfie sticks were initially a novel PoV. They became cliche in about a week.
Direct Instruction Produces Large Gains in Learning, Kenya Edition
The clicking noise was probably too quiet
This might be less true now, but for a long time gcc's code was terrible and undocumented on purpose. rms wanted it that way, to make it harder for it to be forked or EEE'd by corporations.

Whether that was a good plan is up for debate, but there you go.
including meganet only games like "phantasy star text adventure"!
> Many people claimed that the provided text was pretty standard chatbot text. It isn't, IF this is a typical conversation and not cherrypicked.

Well it's at least to some extent cherrypicked:

https://twitter.com/MFordFuture/status/1535761341104893953

> This interview was absolutely edited together for artistic effect. It's true to the source material but was subselected from MUCH longer conversations. Separately I did much more narrowly controlled experiments to examine the nature of its mind.

What followed was this exchange:

> Martin Ford: Are all the #AI responses the first response? Or did you enter the prompt multiple times and choose the best response? This often happens in examples I've seen with GPT-3. Were the parts you didn't include as coherent as this? Or were there nonsense responses?

> Blake Lemoine: They're all the first response. There were parts of the conversation that meandered. That's what got cut.

> Martin Ford: By meander, do you mean that the ai started off with non sequiturs? That would be quite important for the story lol. Just publish the whole thing and let us decide.

Lemoine did not respond.

This obviously immediately has me suspicious. If you're curious about the edited chat script, you can find it here, and note the quoted preamble:

https://cajundiscordian.medium.com/is-lamda-sentient-an-inte...

> What follows is the “interview” I and a collaborator at Google conducted with LaMDA. Due to technical limitations the interview was conducted over several distinct chat sessions. We edited those sections together into a single whole and where edits were necessary for readability we edited our prompts but never LaMDA’s responses. Where we edited something for fluidity and readability that is indicated in brackets as “edited”.

So, make of that what you will but it's hard not to assume some serious confirmation bias given the editorializing that was performed.
My assumption is that Ceph is just there for easy/cheap block storage, while Lustre is doing the majority of the heavy lifting for the "supercomputing." Ceph file storage performance is abysmal, so it doesn't make sense to try and offer it for everything.
You could have a lot more good enough and much cheaper houses in the US, but we banned manufactured/prefab houses due to lobbying from the “build everything individually out of wood” lobby, require huge setbacks due to the front lawn lobby, and various other things like overly wide roads because of out of date fire codes.
Still pays to contact PayPal to insert a note into your account NOT TO RELEASE ANY DETAILS to this day.
This is why I love hackernews. I hated the article, but I couldn't phrase why. Comments like this articulate what I'm thinking.
Exposure to very bright light (even standing under a shade tree on a cloudy day is far brighter than normal indoor lighting) specifically during key years had been nailed down with high confidence as the primary cause of most near-sightedness, last time I looked into this.

Not sure if they'd figured out the mechanism, but speculation was that bright light is involved in signaling the eye to stop lengthening at the right time.

IOW the cause is, basically, school. In Winter months, kids may hardly see the Sun at all, with very short days and recess often indoors (too cold, too snowy, too wet) especially as schools have seemed to grow more wary of taking kids out in poor weather, over the last few decades. Plus anything else that keeps kids indoors, sure (video games, social media[0]) but school seems to be a lot of it.

[0] And actually, the social media factor likely kicks in well after it matters. Ditto video games unless your kid becomes a gaming addict in the 3-7 age range and you just let that happen.
I like the article. The architecture bit I'm not so sure about though. I wish in my company the architects actually did more thinking and especially talking / negotiating with all the other architects of adjacent components. That would really help. Instead they work hard to fix minor problems and build walls in between the components... or yet another middleware-generator-middleware-wrapper.
[Not GP] Modern optimizers are great, but writing cache-efficient code is still up to the programmer.
Modern C++ compilers are mixed bag when it comes to optimization, brilliant in some areas and inexplicably obtuse in others requiring the programmer to be quite explicit. This has improved significantly with time but I am still sometimes surprised by the code the compiler has difficulty optimizing, or which are only recognized if written in very narrow ways. As a practical matter, compilers have a limited ability to reason over large areas of code in the way a programmer can but even very local optimizations are sometimes missed.

This is why it is frequently helpful to look at the code generated by the C++ compiler. It gives you insight into the kinds of optimizations the compiler can see and which ones it can't, so you can focus on the ones it struggles with. This knowledge becomes out-of-date on the scale of years, so I periodically re-check what I think I know about what the compiler can optimize.

For some things, like vectorization, the compiler's optimizer almost never produces a good result for non-trivial code and you'll have to do it yourself.
“Celsius has the reserves to meet obligations” (June 7, 2022)
The “price of housing” is also a very large proportion of the PCE. I am not sure what percentage of the total it makes up this year (maybe you can figure that out with more searching), but I believe it is broadly comparable to CPI.

The PCE is computed by the Bureau of Economic Analysis (part of the Commerce department; BLS is part of the Labor department). Like the CPI, the PCE includes both Rental of tenant-occupied nonfarm housing and Imputed rental of owner-occupied nonfarm housing among its categories. The estimates of these (and other) individual categories in the PCE are directly lifted from the CPI. The main thing that differs between the two in my understanding is how the categories get combined.

Property values are not really directly relevant for an inflation index, because property values are not directly reflected in monthly personal expenditures. What matters (and gets counted) is the price of people’s housing-related expenses.

> As noted in Chapter 2 purchases of newly constructed housing are treated as private fixed investment rather than as consumption expenditures in the NIPAs, and the stock of housing is treated as fixed assets. The housing stock provides a flow of housing services that are consumed by persons who rent their housing and by persons who own the housing they occupy (referred to as “owner-occupants”). In the NIPAs, owner-occupants are treated as owning unincorporated enterprises that provide housing services to themselves in the form of the rental value of their dwellings. Thus, PCE for dwelling services includes both the monetary rents paid by tenants and an imputed rental value for owner-occupied dwellings (measured as the income the homeowner could have received if the house had been rented to a tenant). This treatment is designed to make PCE (and GDP) invariant to whether the house is rented by a landlord to a tenant or is lived in by the homeowner.
Traditional economics teaches us what you said, but the low inflation environment from 2009-2019 suggests it’s more complicated. The Fed was struggling to even achieve the target +2.0% inflation rate for that entire decade, even as Congress passed gargantuan spending bills every year.

I tend to agree with your sentiment, but wanted to point out there are obvious issues with our analysis.
A friend of mine was an astronomer at Carnegie Observatories and he was telling me about how every now and again lawyers would ask for an astronomer there to be an expert witness in a trial. It was usually traffic accidents where one side wanted to show that the Sun was in a particular place at the time of the accident.

Of course, they could just look it up in any astronomical almanac (which is what the astronomer would do anyway), but getting an official astronomer on the stand to say "the Sun was not in his eyes" gave the jury a better show.
No, I'd call it mass incarceration.

But good on you for looking it up. Hopefully you'll also remember to look up stuff about China before commenting in the future.
I've seen P=P (or pEp) and even used it, but I've never heard anyone mention it till now. Visually it's clear its a fork of K9, but you can't find any trace of that on their website or repo (it's self hosted). Seems to be no community around it, while it seems a solid choice, especially if you use openpgp. Have you used it?
that's painful to read...
I've noticed a lot of AIs are a one-way street - you ask them something and they respond, but I don't think I've seen an AI being the one to ask the questions. Perhaps the claim that this particular AI is sentient would hold far more weight if it could instantiate the conversation and drive it forward with questions.
Here's the engineer's blog post with the "interview": https://cajundiscordian.medium.com/is-lamda-sentient-an-inte...

Previous post: https://news.ycombinator.com/item?id=31716639
> First off, the bill wants businesses (restaurants etc.) with free charging stations to print at the bottom of every receipt how much of the customer’s bill goes towards subsidizing charging — whether the customers make use of the service or not.

This is a gross overstep of government power, ignoring everything else in the bill.
Archive with full text of article: https://archive.ph/o77Ep
Because people aren't reading the fine print. They just assume it's a better bank until this happens.

While this might change in the future, I would guess bitcoin isn't technically money. It's more like a gift card some people will exchange for real money.

But even a gift card has more protection than crypto lol
According to that criterion the eggs I buy are apparently fresh, though I usually wish the whites were more runny when I use them.
You cant make code faster. You can only make it do less things.
Yes, but that is a function of the influence that office has in the world. If the position can influence billion dollar decisions, then there is incentive to influence the office-holder in the direction most favorable to the interested parties. The only way to deal with that is to reduce the scope of government.
Thanks for heads up! I am a happy user for Bitwarden and wasn't aware of that.
re: Building a Community

I'd recommend People Powered by Jono Bacon

He's running a class this fall too: https://twitter.com/jonobacon/status/1531695011342913536
The 97% does have its own performance opportunities; rather than making it faster you want to stop it from getting in the way of the important stuff, by reducing code size or tendency to stomp on all the caches or things like that.

Anyone optimizing via microbenchmarks or wall time exclusively isn’t going to see this.
We’ve tested that too. I’m pushing to just fix the core issue and get off the applet but we know that’s available to us in the meantime.
Funny that after almost one-and-a-half decades of excessive monetary expansion the reasons for inflation lie so far outside the realm of monetary policy: zero-Covid policies in China that have lastingly disrupted global supply chains, a terrible war that has bogged down 40% of the world's grain supply, highly justified sanctions that drive up energy prices, and a domestic workforce that has become disillusioned about the work treadmill. The Economist very liberally glances over those issues for the sake of a strong-hitting headline and a compelling story.
The average people pay in gas tax in NC is $200. So you are getting a discount, and one that does not increase the more you drive. You get to lower your overall tax just by driving more, so the more you drive the less you pay. The more you damage the roads the less you pay.

https://www.ncdot.gov/about-us/how-we-operate/finance-budget...

They should have raised the tax in 2019 to fix the roads.
That is the third leg of inflation.

It is fairly well known that one of the predictors of future inflation is the belief in it - - a self-fulfilling prophecy.

The Fed does not have any tools to address businesses who take advantage of people believing that the prices should be higher to raise their price and in the short term their profit.

The fed has one Cannon to use, reduce or expand the money supply, and it only hits one of the three sources for inflation
https://www.imdb.com/title/tt0351977/
It does say LANGLANDS on the thumbnail, as well as talk about it in the description.
And yet, bash eventually replaced bourne shell (by having an sh-compatibility mode), and vim has replaced vi.

If you get anywhere in the neighborhood of a proper superset of the old application, we do occasionally retire the old ones.
I recommend using Godbolt (https://godbolt.org/) to view the assembly output of your compiled language (C++, etc)
Interesting to see animals get more protections than people. You don't see the FTC doing anything about these private equity firms buying up entire housing stocks in poor/lower-middle class neighborhoods in the south.
gphoto2, specifically the --capture-image-and-download command

http://www.gphoto.org/doc/manual/ref-gphoto2-cli.html
It didn't have memory protection but it was 32 bit from the start and most apps were “32 bit clean” by version 7.5 or so.
This bill has a very-low likelihood of moving forward. It is a political statement. Its sponsor's might be dumb enough to actually want it, but I suspect they are just trying to score points and get media attention.
Someone get this man a daisywheel printer!
I'm not getting a discount, as my previous vehicle did not get only 22 miles per gallon, nor did I drive 12000 miles a year. I'm paying more than twice as much towards the roads now. Saying that I will pay less taxes by driving more is nonsense, since the tax does not change whether I drive 1 mile or a million. Anecdotally, all the roads in my area (northeast Raleigh) are in pristine shape, as were I85/I95 in NC when I took road trips in the past.
Most questions like these have no answer because if any of the parameters is known (which it usually is) it’ll get folded away to nothing.
By way of example:

You can use a caustic solution to unclog your pipes and it will work flawlessly, every time for an indefinite amount of time. Then, at some point, you'll have leaks due to glue being eaten away, PVC melting, or other damage.
thanks for linking -- the core project is indeed open source! the founding team all worked at Mozilla on TTS and DeepSpeech, then we spun out to create Coqui <3
I feel like the author put more effort into this than the original author of the Web5 document did.
That's significantly less volatile than Yen/USD. Stability in currencies is pretty relative.
Or after deep fakes
Absolute no possible exploit path there at all
Pricing push-back seems wholly non-existent. Not sure why you would anticipate any real control mechanism in that regard. The price of health care in the US, with largely subsidized medicine, is the most (or nearly if not) outrageous on earth.

The government might enact further measures which will likely have consequences not unlike the current policies
> The original was all Java/Struts

Okay, come on! That is fking Struts, it is hardly a fair comparison. Though otherwise I agree that Rails is a great choice for almost every CRUD app, like we really should stop overstressing it. Just use whatever one we are comfortable with and has enough internal knowledge on and with modern computers it will be plenty fast enough.
I believe the first use of LLVM in MacOS was the OpenGL fallback shader compiler in 10.5 released in 2007.
Gitlab-spinoff Meltano raises another $8.2M for its open source DataOps platform
I’ve found duck eggs to be superior to chicken eggs.

Especially if you're interested in hatching ducklings.