skysight-inc/HackerNews huggingface dataset:
> I'm worried that it will take many years until that happens.

For good reason. If we detect cancers early, surgery and radiation are often very good nowadays--often allowing you to skip chemotherapy. And these are far less likely to kill the patient than a checkpoint inhibitor (which can overload your kidneys if it works or give you autoimmune diseases even if it doesn't).

The problem is that there are a lot of cancers we don't detect early-lobular breast cancer, pancreatic cancer, etc. And for things like intestinal cancers radiation is particularly bad.

These kinds of immune treatments are likely to get promoted first line treatments quickly if they really are this good--especially since they are likely to work on stage 4 metastatic cancers for which we don't have anything decent.
see also http://mazur-archives.s3.amazonaws.com/aol-files/index.html
> I am assuming it's not really "pick any subject you like"

It appears your apparent confusion is due to this assumption. It's the opposite of the process I described above.

I meant exactly what I said. The candidate can pick any topic they like. I trust the candidate to pick a topic to showcase their own skills -- and if they don't, that's another useful datapoint for the hiring process.

There's a huge difference between using a predefined process vs letting the candidate drive. It guarantees we won't waste time talking about subjects the candidate isn't familiar with, and that we will focus on their strengths. Figuring out a candidate's strengths is the entire point of interviewing!

It's also relevant to the "fairness" issue mentioned above, for the same reason.
They haven't been $0.12 in PG&E territory since ~2010. Seems like the data source must be very misleading.
An article from late 2015 indicates that IRC is nothing more than an API interface and not their underlying system.

https://blog.twitch.tv/en/2015/12/18/twitch-engineering-an-i...
I made the mistake of buying Eufy camera and the app is basically an sales channel spamming you with ads on every occasion. If you contact support and complain about it they will disable popus for you but the app is still full of spam and animated icons inviting you to buy something.
They clearly have zero respect for customers.
> Because biology. Mothers have to take time off work (to give birth), fathers don’t.

This is not true. Just google "woman gives birth at work" for many examples. https://www.newsweek.com/colorado-woman-gives-birth-car-deal...

Also, in general, American workers tend to get fewer days off work than European workers, but it doesn't have to be that way.

Let's say a woman works 45 years during her life. That's well over 10,000 working days. And let's say she has 2 kids. How many days off do you think she needs, medically speaking, for childbirth? The percentage is very very low.
And the GNU project. Let’s not forget their contribution to this story!
I imagine that locomotives have redundancy of some sort so a single mechanical failure should not cause paralysis.

Other than that, having some padding and a schedule should get you two nines.

I imagine you have to strech the schedule or skip maintenance to get that sort of cascading failures.
Me seconds before clicking the link, “I swear to fucking god if this doesn’t involve leeks fighting each other… I’m gonna be so pissed.”

Me immediately after clicking the link, “yes. Hahaha YES!”
A few DBMS innovations:

- The "No[t just ]SQL" movement brought us schema-free DBs (among other things; note that I personally prefer schema enforcement and strong typing);

- CouchDB and others started to integrate MapReduce-style support for distributed processing;

- Increased support for polygon/centroid indexing: PostgreSQL -> PostGIS, SQLite -> SpatiaLite

- Graph databases: RedisGraph, SparkSee, Neo4j, AllegroGraph and others - as well as Cypher as a de-facto query language standard (supported by Neo4J, RedisGraph and others)

Some senior DB people like Gerhard Weikum ( http://people.mpi-inf.mpg.de/~weikum/ ) switched from databases to Web mining, because they believe that is where the action is now: acquiring/learning
structured data from unstructured sources.
Neither of those sound unique to Diablo Immortal. Several games employ the "purchase a daily bonus" mechanic. Diablo also has several free login bonuses, like the daily kills and the blue crest (which granted, is a way to push purple crests, but it's still a daily free item).
When this happens I also make a point of leaving an appropriate review, not only as a more reliable method of closing the feedback loop but to provide a warning to other potential victims.
I hope that if V2G happens we'll start seeing electricity arbitrage from Santa Clara to nearby communities. We desperately need competition in that market.
“1-5 tabs gets me a warm fuzzy body high”

no one cares
88.4% successfull checkins sounds quite low. With thousands of people in the program thats a very high failure rate. Of course some of it may be intentional, but even if half of it is intentional thats a huge amount of unintentional failures to check in. Not sure how they can sell that as a success.
Is this the same animal? If so we can take this as disproven as Chileans don't look younger than other people :)
I think the problem is that you've only been playing for a few days. Usually these kinds of games are actually fun for the first few days or weeks. It only gets back once you've already invested a lot of time and effort into the game and are hooked onto it.

Of course you may have the self control to pull out when you notice it becoming less fun but that's not easy for everyone which is why this model is quite predatory.
Sea squirt is the single thing I had on a trip to Korea that I didn't enjoy. This description is bang on.
A call to Math.random() will in fact repeat eventually. The backing PRNG has a finite period.
Belonging to the former.

Fine here's 3 years to prove it on 0.25FTE... next paper please.
> the current techbro rituals

As someone who's never interviewed at FAANG and only ever gotten either relevant (paid!) take-home programming assignments or the CS101 bullshit the author talked about, what do you mean by that?
You treat it like any other job. The people who are writing these kinds of papers are actual career scientists.

You start with a literature review and textbook search. read 5-10 different undergraduate astronomy and physics text books, then undertake a current literature review. Do searches in science journals that you might get free from your local library, or the library associated with your alma mater if you have connections there still.

That gets you the basic knowledge needed.

Next is the hard part, using current state of knowledge, finding current data sets, finding your own algorithms for "scratching your own itch"

Writing the script/programming is the last step - the least skilled step.

Imagine you are John Carmack writing Doom for the first time. He had to know the math, look for "at the time state of the art" university dissertations regarding 3d rendering and occlusion, etc and combine that with his own knowledge about coding, assembly language, and put all that together to make Doom run on the hardware he had access to at the time.

It's exactly the same for any field. Be humble, learn the basics, get caught up on current research, read deeply, read other people's disserations and ideas, then using what you have, and combine it with other people's ideas, and then you start the programming part (or you can hire people to code it for you, nothing wrong with that). and that's how it works.

We all stand on the shoulders of giants who come before us.
Same, I don’t have time to dork with notifications I don’t need.

Once I get a bad notification I have no faith in an apps willingness to do what I want.
Flippin' eck, I've just tried reading the opening sentence:

> A number of philosophers endorse, without argument, the view that there’s something it’s like consciously to think that p, which is distinct from what it’s like consciously to think that q.

I've re-read it umpteen times and by brain still refuses to parse it. This is not, IMHO, articulating anything clearly or precisely.
I said truthy, not truthful. They're often fairly accurate reports about what they did/recorded (I said "often," mind, not always -- p-hacking is a common lie of omission). That doesn't mean they're accurate predictions about future results, as studies are extremely limited in their scope, size, control, etc., which is one of two factors behind the replication crisis. The other factor being that replication studies are rare.

When I read headlines/articles like this, I think "oh neat, I wonder if somebody will identify the mechanism behind some mystery protein acting on whatever system in mice, and if that interaction has an analogue in humans." People on HN frequently seem to be enraged rather than curious about studies with overblown headlines, and it's a little sad.
I use the Logitech MX Vertical, highly recommended.
>it earned Mr. Huffman an audience with Congress. He testified that investing advice on the forum was “probably among the best” because it has to be embraced by a crowd.

Not the best logic. Crowds embrace a lot of bad ideas.

During the height of the Gamestop madness I had some exchanges in WSB questioning some of the claims. At the end of the day, a vast majority seemed to have no idea what was going on or how markets worked. They were just jumping on the bandwagon and blinding throwing money in because reddit told them to.

Just because they were able to generate movement by captivating a large enough crowd, doesn't mean it's a great source for investing advice. The whole subreddit seems to be founded on celebrating massives losses and treating stocks like slot machines. Meme stocks just seem like crowd funded pump and dumps.

If anyone runs into the WSJ paywall, but happens to have Apple News+, here is the link to the article. https://apple.news/AIYqY8ABYTw6r9Dc8x4xrMA
Making blockchain stop wasting energy by getting it to manage energy
Assign and Save Assembly Obfuscation Settings Within Skater Obfuscator GUI?
I'm sad that phone notifications aren't in the same category of governance as email. The promotional vs transactional requirement could be used to good effect here with opt out and CAN-SPAM legislation.
Read CV
I agree that GBs for 100Ks of go routines is not in some sense "a lot", in that you might still be using memory pretty effectively. But I don't see that a "6GB vs 1 core" tradeoff makes any sense to talk about.

We have HTTP ingress that needs ~100 cores but could theoretically all fit in 1GB. We have k/v stores that need only 16 cores but would like 500GB. And we have data points at most places in-between. We can't give the ingress 600GB instead, and we can't give the k/v stores 100 cores. So the fact they're financially interchangeable is meaningless for capacity planning.

Arguably, for most code and especially in a GCd language, using less memory and less CPU go hand-in-hand.
oh wow HN is parroting this bullshit again.

Moxie and Signal didn't do anything other than asking LibreSignal politely to stop using their servers. They didn't "shut down" anything, and they have shown no interest in shutting down signal-cli/signald.

MobileCoin, the cryptocurrency that Signal incorporates and essentially sanctions, uses signald for their bot[0].

the Signal Matrix bridge has hundreds if not thousands of open source users, plus Element One and Beeper users, all using signald and not having any repercussions for years. The only 3rd party Signal client that's caught any flak from Signal that I'm aware of is LibreSignal.

also see: last time this came up[1]

[0] https://github.com/mobilecoinofficial/mobot/blob/dev/RUN.md

[1] https://news.ycombinator.com/item?id=27682490#27683374
I think you still don’t really understand what is meant by placebo effect and are putting way too much stock in the power of low dose psychedelics.

FYI I have microdosed and it felt great but I wasn’t trying to tease out an effect. I think there’s a decent chance that the lift I got was because I felt mischevious, like, i just took some fing acid this morning and here I am at work. Solid lift.

If there is some effect, then a blinded study should show a response. It doesn’t come down to ‘magic’ that works only if you know you’re taking the actual thing and have the right set and setting. By your own example, a blinded study that was run without the important steps you mention should correspondingly show people with both positive and negative effects which would appear in results. If you don’t have these results, then you have a bunk field that is just pseudoscience. Now this study may or may not be of that good a quality, but it goes in the evidence pile.

> Sorry, I'm not an expert in this field, I'm a software engineer. Just wanted to share my subjective experiences.

It’s clear that you’re sharing your subjective experiences, but that is not at all how you presented it, you presented it as though the study is wrong because of your experience. The study could be wrong, but the study is (at least ostensibly) attempting to follow the scientific method. Your dogmatic defence of a technique you clearly believe in (and to be clear, I don’t want to invalidate the benefit you say you have received from it) does not in any way contribute positively to what the objective of science is - to get to the truth.

The broader picture here is that if there are high quality studies that demonstrate that micro dosing has some minor, or even significant effects on subjective experience when appropriately blinded, then it is a field for further study and potential adoption into therapy or other areas in controlled situations.
If it shows nothing, then it is like the whole field of pseudoscience where the labours and efforts of people and mis allocation of resources to something that provides no benefit (and, on a re-run of history may never be developed, as opposed to science, which would come out the same way)
Great so why is exploritory stuff being published without being completed? This isn't a known to work vaccine or equivalent.
The best example of a complex system is the human body. It's useful to juxtapose such a complex system to a "complicated machine" such as a car as far as you they breakdown (i.e. collapse).

A single part failure can easily cause a car to become completely undrivable, whereas a surprisingly amount can go wrong with human body and it works more or less the same.

Not enough fuel and a car stops. It's completely binary, either you enough gas to go, or you can't go. For a human there is an incredible range of failure modes for not having enough fuel. Humans can survive an absurdly long time when they are 'empty' of food.

However once that human body does fail, it's over. Additionally all parts of it collapse together.

A car is more or less the sum of it's parts. You can take each individual part and take it off and reuse it, like wise each failing impacts primarily it self. The engine can go find with a flat tire, you can use the headlights on car with no gas and no wheels until the batteries fall out. When an essential component for driving the car fails, all of the other components are still useful. This also means that any piece that is necessarily for the car to drive causes complete failure for the system when it fails. But it also means you can restore the system trivially by repairing a single part.

The human body is more than the sum of it's parts. You can't trivially remove or replace parts. The upside is it is wildly resistant to failure. You can lose an eye and still see, you can lose huge parts of the brain and still function, you can damage a leg running a marathon and still find a way to finish rather quickly, the entire system can be under attack by an invader and automatically defend it self.

But there are limit and when they are cross the entire system fails completely and irreversibly. And in this sense they do collapse faster because once that limit is crossed the system rapidly starts to fail and can never be restored.
Guide: How to use Skater .NET obfuscator’s Command-line Interface in 2022
To add to what other commenters have already said: the car in question was manufactured in the US, not Berlin.
It's a pretty great Diablo experience on an iPad with a controller. It is sad that you can't just pay a decent amount of money to get a classic experience. Maybe people will discover a path where you could pay a reasonable sum of money to get a fairly normal grinding experience with Diablo. I'm not opposed to in-app purchases, but I'm not a gambler, and I don't support gambling business models.

I saw some reviews and write-ups saying that it would be more fun as a $10 game, but I think that's part of the problem. This is not a $10 game. It should be fully priced.

For whatever reason, proper up-front never took hold on mobile. I know Apple really pushed 99-cent apps early on, and maybe that is part of the genesis of this. It has been even harder to convince Android users to pay for apps and games. And so here we are.

I suspect it would be really hard to convince people to pay $60 for a mobile game after all these years of cheap and free games, no matter how good and how expensive it was to make. It's kind of illogical when you think about it. The latest iPhones are at least base PS4 in terms of power. The iPad Air And Pros are well beyond that.

As others have noted, there are ways to make f2p work well. You can do season passes and cosmetic stuff. You don't have to go whale hunting.

Realistically, we probably need legislation to make this kind of whale hunting illegal. We also need Apple and Google to step up and start caring about business models that support great software.

It's not just games, we aren't getting great mobile software in general -- at least not at the rate we saw with desktop computers.
We used to until Dr Beeching
Interesting, I will give it a try.

It reminds me Gladiabots (https://store.steampowered.com/app/871930/GLADIABOTS__AI_Com...), but the target audience is not the same.
so it's like comparing a downer to an upper, right? not the best comparison in my books.
> More precisely, OS threads, because of their scarcity, introduce an artificial bound on throughput that's lower than what the hardware can support, and usermode threads remove that bound.

Why are OS threads scarce? The OS allocates thread stacks lazily. Given a kernel stack of ~8kb (two pages) and a user stack of ~4kb, one could spawn 100k threads with just over 1GB. A userspace runtime will allow you to bring that number down, but if you're at the scale of concurrency it is unlikely to matter much.
Skater .NET Obfuscator
Skater Obfuscator makes the prevention of pirate attempts to decipher your software, protection against such attempts and alteration of your software to ensure that it functionality degrades in a subtle way if the protection fails.
Lions Mane is best
Full self driving is the biggest joke... if at least they would have called it self-driving... or half-self-driving
Yeah, after it loops in several hundred years and I hear a pattern I've already heard, I'll be really annoyed!
That's like the whole point of this article....
I'm kind of confused as to the benefits of a Tesla. You get a car that has less rigorous quality control and is less maintainable. Why take the risk?
This looks really cool! Any plans to support rerouting traffic entirely, rather than just mirroring?
You might be partially right, Russian military bloggers state this version too. Like there were tons of money invested into bribing Ukrainian political forces but it was stolen on both sides.

However, right before retreat Russians were not in a disasterous state at the borders of Kyiv. In fact they were slowly closing the circle around it. If the focus were there, and additional forces were applied, it could have succeeded.
Russians had heavy losses during deployments, but once positions were taken it all stabilised for them, so it was not as disasterous as many say. It was not that Ukrainian forces pushed Russians back, but more like Russians regrouped.

From what I see in the last weeks, Ukrainian artillery is not capable of achieving goals. It could have been different before, but now a lot of videos from Ukrainian brigades depict that artillery support is missing and they go to battles without any support.
I don’t see what this says about notifications
I walk forward a lot more than I walk side to side, and the stuff I pay attention to when walking is more generally arranged vertically than horizontally.

All I’m saying is the appeal to nature of landscape mode doesn’t seem like the whole story.
xor will not overflow and is obviously correct.

I'm not sure modulus-addition would be correct.
mine won't compile. it complains about a core leek
In the conclusion the author states:

>"Go run-time scheduler multiplexes goroutines onto threads and when a thread blocks, the run-time moves the blocked goroutines to another runnable kernel thread to achieve the highest efficiency possible."

Why would the Go run-time move the blocked goroutines to another runnable kernel thread? If it is currently blocked it won't be schedulable regardless no?
> Should the government have not helped fund this drug because now it's expensive?

If he wants to charge "what the market will bear," then he should fund the research through the market.

If he wants government handouts to do the research then the public deserves to get the benefit that it's paying for - we're not funding it to make some guy rich.

I'm not saying it should be free, but he's already opted out of the market, so he loses out on market pricing. Manufacturing cost plus some reasonable percentage for the creator.
That's because serotonin circuits (where LSD and magic mushrooms act on) are antagonists to dopaminergic circuits [1].

[1] https://moleculeofmore.com/
Your comment is one of several on this article. Some enraged/dismissive, some overly credulous. It's the lack of curiousity I find disappointing.
Wrong, calculating n(n-1)/2 is O(1)
Proper up-front never occurred because Apple refuses to implement a simple free-trial-period mechanism. And it is impossible to filter store searches in a way that tells you which apps would behave roughly in that way (therefore anything with IAP I just assume must be a gambling/gem-bags/garbage model).
Office web apps are free with OneDrive and 5GB storage. $20/yr for 100GB. Office 365 personal is $70/yr. What would you rather see instead?

Disclosure: I work for Microsoft.
Most people seem to know that HOAs are troublesome and should be avoided, though.
LSD is not exactly a downer. The decreased activity is because serotonin circuits are antagonists to dopamine circuits.
I doubt people will say general intelligence or fusion are "all engineering" in 50 years. We'll need some sort of breakthrough. There's the "weak" self driving we already have and there's the "strong" replace a human or outperform a human in any situation which is more like general intelligence. These are very different kinds of problems. I'm not well versed in the details of the space program but I doubt there were many "impossible" steps that required some fundamental scientific advancement. But hey, +1 to the optimism that we'll still be around in 50 years ;)
If we just let the fossil fuel infrastructure rust/sink? Lots definitely destroyed.

Perhaps material-neutral "value" is not a particular good measure of anything.
More than the question of how that got past QA, I'm more curious how something like that would even crack unless subjected to extreme forces.
Everything I've reads says the opposite. Elden Ring has sold at least 13.4 million units so far[1], which is >$800 million in revenue. The only revenue figure I could find for Diablo Immortal is $800k [2]. They're not even in the same ballpark.

[1] https://www.polygon.com/23070948/elden-ring-sales-chart-npd-...

[2] https://gameworldobserver.com/2022/06/03/diablo-immortal-gen...
Its just luck. What you worked hard at is also luck.