"Not to criticize too strongly, but given the above, combined with it's reproducabilty crisis, and existential problem of being in the back-pocket of big-pharma, I seriously doubt the professional integrity of a lot of people in the field."

Lack of professional integrity is a very real problem.

Over the past two years I wrote fairly frequently about some of the nonsensical / pseudo-scientific COVID papers that got published, especially the quality problems in epidemiology. Epidemiology isn't bioscience (actually that's one of the problems with it - total lack of biology), but it's adjacent. After that I got contacted by a former research software engineer who worked with top epidemiology teams in the UK. I also got contacted by a member of the SAGE committee.

Both of them told me some absolutely mind-blowing stories of ethical malpractice. I wasn't totally surprised because it was obvious that those sorts of things must have been going on behind the scenes just from reading their model source code, reports, watching their behavior etc. The RSE had become so disgusted at what he'd seen that he actually left the country and switched from working at Oxford to some US university I'd never heard of, switching fields along the way too. Quite the downgrade in prestige but after years of trying to help epidemiologists he concluded the entire field was utterly morally corrupt and he wanted nothing to do with it.

Here are some of the more memorable things I was told by those two scientists:

- The RSE at one point found a bug in a FORTRAN model being used to model malaria outbreaks. It had been used as the basis for hundreds of papers but at critical points was using pointer values as variables instead of dereferencing them. Obviously, a typical pointer has a very different value to most organic things (some FFI bug). He reported this bug to the authors and got a reply back within 30 minutes saying they'd checked the papers (all of them) and it didn't affect the results. This claim was very obviously a lie: not only could they not possibly have checked even one paper in 30 minutes but he already knew fixing the bug did indeed change results! They didn't care and he was shocked that his "colleagues" would bullshit him so directly, especially as they must have known that he would know.

- Same guy flagged code quality issues to some of the scientists and proposed introducing some rules designed to improve quality. He was dismissed with the words: "oh <name>, we're scientists, we don't write bugs".

- The SAGE member told me about some of the internal discussions they had. Criticisms of the methodological validity and accuracies of their models were dismissed with reasoning like this: "that person reads the Spectator so it doesn't matter what they think". Relatedly, he made clear that the supposedly scientific SAGE predictions were sometimes being altered to reduce criticism of the group by left wing media and journalists. The changes were presented as "the science changed" but that wasn't what was going on behind the scenes.

- Malaria research is (supposedly) being badly distorted by the Gates Foundation. Gates only cares about eradication which leads to lots of problems. There are some smaller ones, like many researchers don't genuinely believe that's possible but lie on their grant applications to make mitigation efforts sound like eradication efforts. And then there were unethical experiments on entire populations where e.g. whole areas are blanketed in anti-malarial drugs. If it works, great, you eradicated malaria in that area. If it doesn't you just selected for drug-resistant mosquitos and now the drugs that were being used only to treat the serious cases don't work for anyone. He told me this has actually happened more than once.

- The RSE told me they'd at one point tried to recruit an RSE working with climatologists to help them with their modelling (a belief that climatologists are more rigorous than they are seems to be common in epidemiology). The RSE they interviewed refused to take the job. His reason was he was quitting academia entirely, as he was so disturbed by the practices he'd seen.

A few years ago if you'd told me that a whole research field could be unethical I'd have thought you were crazy because, well, that's a whole lot of people being painted by a very broad brush. Now I've seen it for myself and heard from other former insiders, it's easy to see what happens - the honest ones discover what's happening and leave. Because academia hardly ever penalizes intellectual dishonesty, the pool of people who remain are the ones who are OK with it and have learned that it works / has no consequences. Things steadily become more and more toxic.