skysight-inc/HackerNews huggingface dataset:
> stem cell exhaustion

if you plug stem cell exhaustion and "telomere" into google, they have relationships in the literature:

As a result, the qualitative and quantitative decrease in stem cell function
during the process of aging, known as stem cell exhaustion, has been specified
as one of the promoters of aging (3,6). The role of telomere loss in the
replicative senescence of stem cells has recently been the focus of
considerable interest.

> epigenetic disregulation

if you plug epigenetic disregulation and "telomere" into google, they have relationships in the literature.

> genomic instability

if you plug genomic instability and "telomere" into google, not surprisingly they have relationship.

> altered cell signaling

I think you can guess what I'm going to say here.

I'm not a cell biologist. I certainly don't think telomeres are the smoking gnu of all of this, but there are indications the commonality of how telomeres alter DNA expression, and the centrality of DNA processing to renew cell function come to the fore: if you don't have a valid end-cap on the instruction set, it may not reproduce accurately which affects all the cellular processes which stem from it's reproduction and application. (a massively overplayed analogy to the digital domain, which is a bit bogus)

> stem cell
Geek Culture – The new internet revolutionising the creativity business
If the environment is a priority for you, is it stupid that you buy an electric vehicle and partially hope that it encourages others to do the same? And would it be stupid if you regretted that Musk was needlessly muddying that?

I don't think either situation is ridiculous.
Compiling modern C# is usually not a problem on Unix. Building the relevant tools yourself is a challenge, but the average macOS dev won't be doing that.
It’s a fruitful area of research for sure, but there is a huge gap between “it invented pig Latin” and “it invented Esperanto/Lojban”. Referring to the first as inventing a language is very misleading.
PRC Defense: Starlink Countermeasures
Olden Golden. Siracusa is a hero.
My only question — do you censor based on politics or political correctness?
Bro. The basic fundamental idea of Computer logic has always been trivial even without understanding of binary. There are tons of mechanisms outside of binary that can mimic logic, there's was never anything mysterious here. Understanding boolean logic and architecture is not a far leap from an intuitive understanding of how computers work.

Human thought and and human intelligence on the other hand was a great and epic concept on the scale of the origin of the universe. It was truly this mysterious epic thing that seemed like something we would never crack. ML brought it down and completely reduced this concept and simplified it by a massive scale. The entire field is now an extension of this curve fitting concept. And the disappointing thing is that the field is correct. That's all intelligence is in the end.

This is all I mean. Not saying ML is less interesting or easier then any other STEM field. All I'm saying is the reduction was massive. The progress is amazing but 99% of the wonder was lost. The scale at which we lacked understanding was covered in a single step and now the average person can understand the basics easier than they can understand something like quantum mechanics. There's still a lot going on in terms of things to discover and things to engineer, but the fundamentals of what's going on are clearer than ever before.

So I think what happened here is that you mistook what I wrote and took offense as if I was attacking the field, I'm not. I'm writing this to explain to you that you're mistaken.

So dial your aggressive shit back. Is everyone from Romania like you? I certainly hope not.
There's notably no solid claims about charge rate. It feels wildly impractical. Trying to send even a modest charge is going to be difficult. Doing so without losing 50%+ efficiency is going to be deeply difficult. I have a hard time imagining projects like this ever succeeding.

What I do imagine ultimately, one day working out is autonomous charge vehicles- vehicles that follow ahead or behind that run a charge cable to your car.
Second this. I played the hell out of the original SC2 back in the day...and UQM improves on the entire experience.

They even updated the Super-Melee mode to be playable over the Internet.
Would be curious if anyone comments on the (quality) of organization/chosen topics on the page.
You're implying that this message has been tampered with, but it has not. It is perfectly authentic. Whoever produced this message possesses the private signing key of youtube.com. This message has in no way been forged.

The only mystery here is why someone is mirroring google mail back to gmail with unexpected envelope recipients. It could be a weird error, or it could be they think they can game the IP reputation system by doing it.

In any case, the fine moderators ought to correct the title, because it is wrong and misleading.
Looks good, that type of game is right up my alley!

I'm adding another vote for GOG and macOs support though :)
I would be interested in seeing actual numbers of people that are positvely benefitting from Starlink in the manner you are describing. Remote locations in Africa numbers just don't seem like a very high number of actual users. I will be most pleasantly surprised if that's where large numbers of users are found. However, I'm guessing users are mainly all techno nerds looking to escape evilCoMonopolyISP. A segment will probably be US based far reaches remote type users. After that, it's a whole lot of stuff in space to benefit a very small number just so other people can point at potential uses
This is a good point. The fact that DALL-E will try to render something, no matter how meaningless the input, is a trait it has in common with many neural networks. If you want to use them for actual work, they should be able to fail rather than freestyle.
Going simpler as possible:

Redis has a simple (but extremely powerful) Pub/Sub implementation[1] that should get you going for a long time.

Postgres also have a simple notify API[2] you can mix it with your own tables and just "notify" that some changes were made (when people say you can do anything with postgres nowadays they are not joking).

You probably can also roll your own implementation in any ACID database. Just keep adding records to an event table and consume them in scheduled batches. Should be more than enough for non real-time applications.

[1]: https://redis.io/docs/manual/pubsub/
[2]: https://www.postgresql.org/docs/current/sql-notify.html
Had a lot of fun playing the online multiplayer shooter AssaultCube many years ago. I remember it had a builtin map editor and people would make insane maps, like one for sniping between several-hundred-meter tall skyscrapers
The amount you can buy for I-bonds is too small for a retirement portfolio (which, i think needs to have a total asset of around $1million to make retirement self-sufficient).
This might be a better gRPC for Go. When I read the title I expected a new protocol based on gRPC, maybe something like Cap'n Proto.
Hi schrep! Unrelated to the article, but I wanted to say thanks for taking the time to talk to me at the 'Silicon Valley comes to Cambridge' event in Nov 2010, back when I was just a 2nd year cs student! You not only motivated me to aim high and to apply to FB, but also actually submitted an internship referral!
I didn't end up doing an internship that year (was my first ever coding interview and I did not do well!!), but partly because of this very positive interaction, I later on did end up joining Facebook right out of university! I spent seven years there from 2014 to 2021 working on messaging infra and had a great time (and i miss our infra stack)! Thanks again for talking to a clueless 2nd year student back then!
I’d imagine they work nicely for software engineering, but even then a lot of jobs out there are requiring degrees and might attribute too much ti the brand of college. Some sort of objective skill evaluation that is also officially recognized must be implemented in addition to actual knowledge acquisition. As I understand it if you are a doctor and capable in every way if you don’t have the degrees you can’t even be tested?
Something I can add since I started blocking remote fonts completely in uBlock Origin a couple of days ago: I’ve been noticing lots of broken icon fonts now where I hadn’t before; my working hypothesis is that under the flag we’ve been talking about, Firefox excepts Private Use Area code points and happily loads web fonts for those specific cases. Thus, the cases we’ve been observing of broken icon fonts are where the fonts didn’t use the PUA, whether they tried to choose decent fallbacks (like DuckDuckGo), or used the ligation technique (Material Icons), or just did something weird for no obvious reason.
The fact that they called out Vantablack didn't strike you as being tongue-firmly-planted-in-cheek? You really sound like someone is grabbing a raw nerve with you and unable to see we're on your side poking fun.
Cities for Work-Life Balance in 2022
Warsow - quake3 cpma clone. So good.
Yea or do virtual classes or even video classes with distributed TAs that answer questions.
On a related note, how did you fund the development over such a long timeframe?
I would still highly recommend digging up the proprietary assets though, in particular the music [1] is far superior.

[1]: https://www.youtube.com/watch?v=tI3-Wwl5Xtg
Yes?

I would put mastodon as a competitor of Facebook, don't you?
We have tried that for decades with no success at all.
Incredible. Rather than quit they relaxed for a few months, then convinced Netflix to fire them early with a severance package.

https://youtu.be/Uka17JlB81E
Yes, last mile is so easily solved, the best solution is launching the largest ever artificial satellite constellation the species has ever created. Just so people can update their status.
I got a personalized postcard with my name and a picture of my home, from my local XXXXXXX insurance agent, telling me I could pay as little as $XXX for homeowner's insurance.

Since I already had a policy with him, and just like the postcard said, I was paying hundreds more, I called him and asked if he would lower it.

He said "oh, it's a technical glitch, it's only for new customers, and it doesn't take into account your unique situation and home..."

So I started getting quotes from other places and in about a day I had a new policy at essentially the same low price he had flaunted. I thanked him for bringing it to my attention and cancelled.
This is so true. This false spam tagging has caused me so much pain with paying customers, I ended up white listing all email to a particular to address using a filter.

It's unbelievable that email is so fragile and broken.
This is really interesting, having built your own rpc layer, which parts of the code did you visit to compare implementations? For example: for logging frameworks, I immediately check if they do buffering and support reentrancy.
"The NRA spent $250M on the 2020 presidential election."

These people are flat liars. NRA doesn't have that kind of budget.
Per opensecrets.org, NRA spent $786,052 in campaign donations for the 2020 cycle total (Congress and Presidency). They spent an additional $2.2M in total lobbying costs in 2020 and $3.2M in 2019.

Nothing remotely approaching the claimed "$250 million".
Why airlines have a 91% churn
Impossible colors: our vision’s incomplete palette
Honestly I think email needs to be rethought from the ground up, just a whole new protocol with a killer app to get it going.

Some of the most salient uses/qualities of email:
- Asynchronous communication
- Decentralized / Federated
- Identity

Issues:
- Spam
- Lack of room for the format to expand
- Identification verification is hard

My ideal replacement for email would look something like a decentralized/federated identity protocol with default whitelist for contact upon which you build out data formats for sharing.

One key spam reduction technique in a federated system is to realize that most legitimate interactions are with people and services you are already in contact with so it’s better to make initial connections harder to improve the quality of daily use.
Another tool that works decently in a decentralized system is introductions/vouching. Eg. you can ask mutual contacts to connect you or at larger scale you can entrust third party services to “vouch” for a user, similar to how certs work. If a vouching service does a poor job of vetting who it lets through than users will stop trusting it.
> We need more MITs and Caltechs, not more Harvards and Yales.

While this is a very crass over-generalization, I've found you really see this in the graduates. I've found Ivy league school graduates to be sort of... disconnected from reality? Like experts in education who clearly don't understand any of the on-the-ground realities of teaching (your lesson plan is beautifully structured, but we can't use it because it will make the students cry because they're 7). For the crowd here, imagine reading an academic paper about making improvements to production systems from someone who's clearly never been anywhere near one and is glossing over all the important fiddly details. It's like they've been told that they're smart and going to revolutionize their field and they can do so without ever having to get their hands dirty with more messy details.

To repeat my crass over-generalization, MIT and Caltech style schools seem to do a better job of instilling in students the understanding that if you want to change something you need to understand it, and to really understand it you need to spend time in trenches. I've been consistently more impressed with the results graduates from those schools get.
I'd imagine some mix of legal liability, pr issues, and the fact that Teslas only traverse a minority of the planet would mean it would just be another map & not disruptive to google or apple maps.
cocaine diesel. code originally based on qfusion but most of it removed and rewritten including a new renderer from scratch. its a FPS that highly stylized and it has a bomb defusal game mode and loose concept of classes and loadouts

https://cocainediesel.fun/
You can still donate your BATs to institutions and websites (or should I say "pay for not having ads", at least this is what is being marketed for). I mostly contribute to wikipedia, as it is always in need of new donations and I like the idea of not having trackers/ads on it.

Edit: better wording
These are not the same article. I don't care at all about Kagi, but I care very much about Orion. Except I only know this from the other Orion article (the one now marked "dupe"), which shows that it has native tree-style tabs.
That's correct, I am dismissing all use cases for Facebook. I too personally believe that the negatives (the constant drip of distraction fragments your time and ruins your attention span, you and all of the social capital you invest in the platforms are tiny cogs in M. Zuckerburg's machine, and it displaces the richer interactions we should experience) outweigh the positives.

The underlying cases are important, in fact very important. It's literally building your social life. But I personally think FB is a horrible tool to use for that.

I'm not saying it's easy. You might not get to meet the same people, or many at all. I think it's very different over in the US, as it seems your community groups are deeply entrenched in FB. But - if we think that's bad, someone has to make a start, by doing things another way.

You can disagree, and do your life as you see fit. And just hope you don't get banned from the platform that you have built your life on, but have absolutely no control over nor ability to plead your case.

Edit: A useful analogy might be - imagine a group who have changed their diet to consist almost entirely of candy samples from grocery shops. The response to those shops no longer giving away free candy should not be "but how will these people continue to get their nutrition from free candy?".
The number is indeed millions, not thousands!

Note that it's the number of manuscripts, not the number of distinct works. Many of the manuscripts would be copies of the same popular works (people preserve whatever's most useful), but there is a long tail of works each preserved in very few manuscripts.

The 30-million estimate has been arrived at independently by several people AFAIK, but one of them is David Pingree, and look at e.g. https://www.google.com/search?q=pingree+estimate+million+man... for several sources. In particular, this paper by M. D. Srinivas [1] gives several independent estimates of the number of manuscripts, all in millions. There have been 4.2 million manuscripts actually documented already (as of 2019 when the paper was written), and this paper's estimate is that "10 million is indeed a reasonable estimate for the number of Indian manuscripts that are extant […] the number of manuscripts in Sanskrit can be expected to be of the order of 8 million."

And although this post is about literature, that paper is about Indian astronomy&mathematics, which is perhaps representative:

> We find that of the estimated 9,000 source-works of Indian Astronomy and Mathematics (which are preserved in around 30,000 manuscripts), only about 150 texts were edited, and just 30 texts translated during 1800-1947. During 1948-2019, there has been significant progress and another about 300 texts have been edited and 66 texts translated, many of them with detailed explanatory notes. Thus, only about 450 (or 5% of the estimated 9000 source-texts available) have been edited and published so far; even among the published works, only 96 texts have been seriously studied via translations and explanations with a view to bring out their technical (mathematical-astronomical) content.

[1]: https://insa.nic.in/writereaddata/UpLoadedFiles/IJHS/Vol54_3... and https://www.esamskriti.com/essays/pdf/19%20The%20Untapped%20... = ttps://archive.org/details/srinivas2019/page/n1/mode/2up
I am opposite, I used Android auto once and it was inferior to the car's own: audio distortions, choppy display, takes a while before it figures orientation of the car, does not show in the instrument display and HUD, directions timing is off etc. Distortion and choppiness seem to come from the whatever protocol it uses to communicate with the car, Google Maps on the same phone are pretty smooth.

The car's maps are not as up to date as Google's - they miss some road closures, do not have some businesses names so need to enter address (or can just send a location from Google Map to the car), sometimes believe a street is one-way even if it is not or try to make a turn that does not exist any more but I can deal with an occasional glitch every few months instead of dealing with the inferior UI all the time.
The world’s fastest supercomputer just broke the Exascale barrier
I get the feeling that the intended message is that there is a layoff and that the framing of the layoff being due to efficiency gains is largely bs.
I am equally distracted at home or office, just by different things. At home, kids, fridge, etc. At the office I lose time to the commute, to moving my car every two hours, to office conversations, etc. I burn time reading HN, watching basketball stats and researching roadtrips from either location so they even out.
That assumption is wrong. GraphQL can deliver auth, file downloads, even streams.
Your username is apt.

This title is definitely clickbait-y. The Greeks had a very limited, socially acceptable context for homosexual acts, they had nothing (that we know of) resembling modern attitudes.

This is all with notable asterisks, however. "Sapphic" and "Lesbian" originate from a poet, Sappho, residing on the Greek island of Lesbos, whose work was very... Lesbian.
That's a strawman. You're conflating async with no communication. There's perfectly fine asynchronous communication methods. You have to communicate differently on async, not stop communicating.
I wonder if this could be used to make video HDR versions of D3 visualizations, making more colors addressable at the cost of reducing interactivity after baking the movie file?
I said:

> I mean, you probably think it's a good joke,

That means I thought it was intended to be a joke.

Can you suggest wording that I can use next time that is less confusing?

BTW when the first "they're going to try to make the satellites darker" thing came up, a million redditers seriously mentioned Vantablack. That's not the thing that makes it an obvious joke.
I just completed my 1000th game in SPD, only 70 runs ended with the amulet. I am not ashamed.
Coefficient (https://coefficient.io) | Multiple Roles | Fully Remote | Full time | VC-Backed startup

Coefficient is a fully remote, seed-stage SaaS startup based in the SF Bay Area. Started by repeat founders with successful past exits, Coefficient has raised $6.7M from Foundation Capital, S28 Capital, and prominent angel investors such as Eric Yuan, Zoom founder/CEO.

Coefficient enables users to create custom business tools and real-time dashboards—powered by our platform’s composable no-code building blocks and two-way connectivity to the user’s cloud data sources—all from the familiar canvas of a spreadsheet.

We’re a team of ~20 and growing quickly. Our stack is TypeScript/React/Python/Flask/Postgres and runs in AWS.

Contact: join@coefficient.io

Roles:

Engineering Director - https://coefficient.notion.site/Engineering-Director-25138f6...

Sr Software Engineer - https://coefficient.notion.site/Senior-Backend-Engineer-7360...
I am very sad. I was looking for any happy Prophet news today, and this is what I found.

Thank you for all your creations, Dave. And thank you for keeping them affordable, given their tremendous design complexity and musical capabilities.
Yea. This is why we made our private search completely open on you.com and track absolutely nothing in that mode, not even bugs/warnings/etc.
cpma clone is a stretch would be giving it quite a complement. the only thing that is cpma like is the movement speed and air control. dash and stun not so much - not to mention the low weapon damage. it's also been ill-fated to a single developer running it into the ground with superfluous code and antifeatures
The perception of a "need for so much dev ops nowadays" stems, in my view, from a skills mismatch in the market.

Division of labor and specialization are two natural results of any rapidly evolving industry. The tech industry is no exception. The problem is that there are currently comparatively quite a lot of ways to learn the skills necessary to become a competent web developer, backend engineer, data scientist, etc. Compared to these titles, the ways to learn the skills involved in designing, operating, and maintaining scalable cloud infrastructure have not kept up with market demand.

Kubernetes is not "the" solution, but it is one of several solutions to the problem of standardizing a trade skill for the purposes of making it transferrable. Nobody wants to go to work at a place where the skills they need to do their job well are both difficult to acquire and completely useless once they get a new job.
Even If we ignore the actual achievements of different societies claiming they implement "ism" of one kind or another, any "ism" from XIX century regarding human behavior at scale is naive. If the theory of phlogiston went bust, it doesn't mean physics shouldn't be worked on. Even today, soft sciences are laughable.
I've spent way too much time on Shattered Pixel Dungeon

http://shatteredpixel.com/
I really like the browser, and Kagi as well is giving much better results than Google.

Regarding Orion, is there any built in way to migrate user data (bookmarks/favorites/reading list) automatically from Safari/Firefox/Chrome?

Also, scrolling with a mouse on Mac is discrete/jittery rather than interpolated (this seems to be a problem with Safari as well however). Firefox's scrolling is much nicer by comparison with my Logitech mouse.

I did change some mouse settings so maybe its on my end