skysight-inc/HackerNews huggingface dataset:
Those are good questions and I'll try to answer them all together:

Creating a stably transformed plant is very difficult. A plant is made of b(tr?)illions of cells, and if you insert a "gene of interest" into one of them, it will exist transiently as each cell in the plant has its own cell line. So the standard way is to insert your gene into a cell and then induce/reprogramme it to go through the process of embryogenesis. This is critical because that single cell is the "parent" of every single other cell that will eventually compose the adult plant. Therefore, we can ensure the entire plant is stably transformed. Anything else is essentially chimeric.

The reason it is limited to big corporations is because of: market strategy, regulations, and IP. When the technology reached the point of commercialization, the early adopters decided on producer-centric traits because of: market value, ease of implementation, and ability to upsell.

When you are trying to sell a farmer something, you have to solve one of their problems. What does a farmer hate most? Weeds and other pests. So it's no surprise that the companies selling GM seeds are the same companies selling pesticides. In order to use their seed's technology, you also have to buy their pesticides. Now you've changed your whole farm operation to suit their technology and there's no going back. Gotcha!

It also turns out that getting these cultivars into the market is a big pain in the ass. The regulatory process to get a GM crop into the field and then onto the shelves is time-consuming and expensive... so again the big companies with money can make the investment. Finally, there is a lot of IP protection for these companies; from the seeds, to the chemicals, to the process of plant transformation.

Remember the part about plant transformation and embryogenesis? Very few species can undergo the process reliably - at least we only have methods for a handful. And within each species, there are only a few genotypes that work. Currently, the only GM crops are corn, soybean, cotton, potato, papaya, squash, canola, alfalfa, and sugar beet. Companies can own a patent on certain cultivars of these crops. They also probably own the patent for whatever herbicide the plant is resistant to.

You might ask yourself: Why don't they find out what's different about the genotypes that work and the ones that don't? Well, we did! It turns out there are a few native genes called "developmental regulators" which we can overexpress to force a plant into embryogenesis. That technology is also patented.

However, there are novel methods coming out, and there are startups and small companies doing this: check out Calyxt and Inari.

More will come in the future, but it's an expensive endeavor with a huge upfront cost, overhead, many highly educated employees, and a long time to market. Ag and Food tech VC funding has grown from ~5B (2015) to ~55B (2021) so it's coming.

It will be interesting to see what value-added traits come out next.
At our school, pong was given as a freebie template for building your final project in the digital design course! A great time, ended up enjoy it so much I TAed it till graduation.
I wonder how the Chinese govt would react to ByteDance signing up to grow the economy of China's primary geo-strategic competitor...

https://www.business-standard.com/article/international/tim-...
Interesting, a length of wiggle room for Musk to play with...
If only there was a way parents could exert some sort of influence or authority over these children to prevent what they believe is harmful.

We could call it “parenting”.
A game that makes obvious the games, lies and manipulation of modern politics.

A game that requires people to utilise the dirty politics strategies in order to win, thus making it obvious to the layer how politics actually works.

Things going badly for you? Start a war.

Some bad news in the media cycle? "Throw a dead cat on the table" (look that one up if you don't know what it means).

Have to agree to something? Agree but don't do it.

Need to win an election? Make empty promises.
How does this "wife's boyfriend" thing work?
Well said. Never thought about it from this perspective.
You think all those folks who make billions by being ruthless in business and then create a charitable trust in their name are donating money just out of the goodness of their heart?

Reputation can matter a great deal to a billionaire and many have gone through impressive efforts to burnish theirs.
"The left" is not a monolith. There are plenty of leftist gun owners. It's a practical thing rather than a weird obsession, so it doesn't get as much press.
As someone who used to do academic archaeology, there are plenty of people with both the time, energy, and ideas out there. The main thing that's missing is money.

Funding is tight to a degree that I don't think people from the traditional STEM disciplines realize. The average grant size is far lower than the average NSF grant despite much greater fieldwork costs [1]. The financial restrictions mean you're constantly weighing how important it really is to do basic checks like carbon dating, or whether you can afford imagery (vs just using a printout of google maps). I remember being heartbroken at losing a drone because the money spent buying it, and having to camp in fields and eat fish for long periods because I couldn't afford lodging/other food.

[1] https://dougsarchaeology.wordpress.com/2014/03/12/does-the-s...
What did it say? Way back machine doesn’t have it either.
use a custom domain, it works most of the time.

however its nothing out of the ordinary to expect from the UAE.
Authy used to just be TOTP IIRC - did that change?
Pong is one of the sample chapters for the "Retrocomputing with Clash" book (https://gergo.erdi.hu/retroclash/). Clash is a hardware description DSL using Haskell, and the book is all about using it to implement progressively more complex 1970s chips.
My stock assumption is that most people will have perfectly adequate network bandwidth for good quality audio streaming. Most of connected world already does. My mobile to mobile tests have been as good I as could want.
It's not just that not everyone has a mobile phone, people who move between different countries change numbers and lose access to their old one. I've been screwed over by this many times. You can't assume someone has the same phone number for their entire life.
Probably a decade or two premature but can't hurt to hedge the bets (there's definitely opportunity to make software that makes fpga and asic compilation from higher level languages easier though - only reason it's not happening is the high talent required and low amount of people at that intersection, there's no way verilog/vhdl is the global minima).
CT Scans of iPods
This is a particularly weak set of arguments: Canada and the Southern US have many _other_ core differences that could explain their different outcome, and so do African Americans and Africans (neither of which are homogeneous by the way, and especially not the latter).

On top of that, it doesn't matter for reparations-purposes whether slavery was, overall, efficient. What matters is whether an institution harmed someone and therefore owes them compensation.
Ah sorry - I read it as 'offer the full free-form weight [that it is/I assumed it is with payment] for free'.
The $5B the FTC fined FB for privacy issues was in part bc of using two factor phone numbers for ads.
Bolt pitched us a ton (we do eight figures of revenue online using a WP-style checkout), we heard them out, did a small demo-type, and I spoke to a bunch of their customers... and we came to similar conclusions. It's overhyped "technology" that has very questionable marketing claims.
which plus ?
the email plus still exists.
and that 7$ vpn+email offer is still there, however its for 2years
If your hot loop is doing configuration setup then your code has bigger problems than this particular pattern.
I came across this idea recently on the author's twitter account and was quite intrigued. Since then i too have been naming each day. Something about flattening each day into a few words seems silly at first but it has a few advantages for me:

- I don't have to think much. I usually already know the name of the day as soon as it's time to write it down.

- I can note them down anywhere at any time.

- seemingly extreme limitations improve my output when working on creative things / self reflective writing, and so on. paralysis by analysis does not obtain here.

it feels like a journaling habit i can actually keep up with, and one that over time would yield some interesting results. I imagine looking back and seeing "huh, most of my day-names were about food i was eating in March and i gained 10lbs" or seeing a shift of emotional tone either side of some "Critically important day". Anyway, if you are like me and you often feel many of your days don't live long or distinctly in the memory; i would certainly recommend trying this method for a fortnight. You may be surprised by how rich a biographical / self-theorizing tool it can be.
Thanks for sharing that, sorry to hear the situation but really interesting thoughts.

In your opinion what lead to the crumbling of the institution of family, that did not happen in other countries?
Enjoy:

https://ui.adsabs.harvard.edu/abs/2022arXiv220510267P/abstra...
Its not helpful to say "the left" or "the right".

The important bit is that each item here is a legal issue.

* Bump-stocks, yes or no?

* Trigger-mods, yes or no? (Especially the ones with burst and/or automatic fire modes).

* Magazines, what size should we ban? Is 10 bullets enough? 30 bullets? 100 bullets?

* Should bullets be regulated in general? We regulate larger-capacity bullets (ex: 155mm artillery shells aren't exactly sold in the streets, nor are 30mm autocannons). So where do we draw the line there?

Its not like mortars and grenade launchers are commonly available at gun stores. We have drawn the line and cutoff many kinds of weapons from normal use within this country. If we draw the line a bit more towards background-checks and removing the "automatic-weapons" (bump-stocks and trigger mods) from legality, that probably will help our country out.
Not a tin foil hat person, there is an uptick in what reads like psychological warfare against Russia, editors really looking for eyeballs by throwing anything on the wall or a wave of investigative reporting
Science Direct would think that given that all their reviewers and authors are paid zero dollars but Science Direct turns a profit.
It is my understanding that bump stocks are currently treated as machine guns, which is to say almost impossible to legally own in the US.

https://www.federalregister.gov/documents/2018/12/26/2018-27...
A lot of the shootings involved someone driving to different states.
Agree with filtering out the content farms, strong disagree on mirror sites --- they often have content that has been deleted for whatever reason from the original source, and it's often useful content too.
its available in the account settings
But why is it necessary? It's not. We can have more if we work together, instead of against each other. The only thing locking phones down does is make everything worse _just_ for Apples sole profit.

And cheers bud, see yah round.
In the US a credit report has things like you haven’t paid on this bill for 30 days, for 60 days, for 90 days. Or your account was sent to collections. And monthly balances on your debts. And how much revolving credit you have.

Not sure exactly what you mean by small credit, but your daily purchases or spending is not on your credit report.

It’s largely similar to what you describe but the information, good and bad is kept for 7 years.
Its a good thing that books like 1491 are increasingly validated with archeology.

The previous prevailing wisdom held that outside of the Aztecs and the Inca sophisticated urban settlement didn't prevail in the Amazon due to the "Green Desert" hypothesis and primitive tools.

This research confirms early Spanish chronicles, previously derided as fanciful, that vast urban settlements existed along rivers for many miles and would stretch continuously for hours as they travelled down river.
this is a talking point that has no proof.
The past 100 years of vaccination were not MRNA vaccines, and while their safety profile may be similar or the same, that cannot yet be known.
It reverts back.
Motorcycles are much more dangerous than every other mode of transportation
Is there a limit as to how many mistrials there can be? Or can trial after trial have 11 jurors vote to acquit, mistrial, wait in jail until new trial, indefinitely?
Last public payphone removed from Manhattan streets
Different genres of games for people who aren't seasoned gamers. I will never be "good" at most FPS and adventure type games, and don't really care enough to spend the time to get good at them, either.

Games beyond click-throughs, simplified turn-based games, Angry Birds, Candy Crush, the 900th iterations of crosswords/hangman/sudoku/etc, would be nice.

Intellectually, emotionally and/or aesthetically satisfying low-skill games are what I want, I guess.
I read the book and found it delivered as advertised. If you were looking for a step-by-step guide then yes that is not what you got but I found it explaine, even excessively so at times, "how to take smart notes."
> Current revenue is 40M

Last valuation of this company was $10+ billion. Absurd. [0]

I'm personally happy to see the correction coming where profits - or lack thereof, more likely around these parts - actually means something these days.

[0]: https://techcrunch.com/2022/01/14/online-checkout-bolt-decac...
A VR game where the objective from the perspective of the player is to balance a large ball on his head. The ball has a tendency to tip and so the player must position his body and head to keep it balanced.

All this happens while music is playing.

From the perspective of those watching, it looks like the player is dancing extremely well to the music.
The amount of space given over to connectors is incredible. Seeing the scans helps me understand Apple's crusade against the headphone jack.
> "my top priority has been to do what’s best for Bolt’s business, customers, and employees"

He listed his priorities right there, first priority is the business, then comes the customers, and the last of his priorities are his employees.
How about this independent analysis:

https://ui.adsabs.harvard.edu/abs/2022arXiv220510267P/abstra...
With firefox and NoScript, you can whitelist the specific JS you need to make those sites work. You do it one time for a site you know you'll come back to often, and then you're done. In my case for example I whitelisted the scripts at old.reddit.com and redditstatic.com, and leave everything else blocked by default and it works fine for my needs (reading comments).

The fact that there are a handful of very frequently used websites that use JS doesn't make it impossible or overly burdensome to take sensible steps to limit which scripts you allow.

I use amazon in firefox with NoScript without issue, and while amazon gets to run some scripts, none of the JS at amazon-adsystem.com ever runs in my browser.

Youtube wants to load JS from over a dozen different places, but you only need to allow a couple to get videos to play (I personally prefer to just download yt videos to disk and watch them in VLC avoiding that issue entirely)
Definately. It seems like I've only been able to get friends with engineering degrees to operate something like JackTrip. But SonoBus I can get regular musicians to use.
You could also be configuring many things.
This is part of why Intel acquired Altera. On the other end of the spectrum, some of the latest AVR families have configurable glue logic akin to a tiny PLD.
As someone who has learned k8s through Minikube examples, k3s was much better experience looking back.
That's right! Americans have freedom, and personal responsibility, so we have big SUVs. Real Americans also 4-wheel in beautiful wilderness, which weak europeans do not have.
The only way is for leadership to model the desired behavior. Do not email people on weekends or odd hours. Do not appear online. Do not check in any code. Talk about your nice relaxing weekend spent gardening. When you see people working say, "I'm not working weekends, so why should you?" Make sure the other leaders are doing the same.

This is going to get most people on board, but a few will still have deeply ingrained bad habits. When you see it, just tell them, "there's no reward at this company for burning out. If you want to work that hard, it's your business, but please do not bother your teammates or set the expectation they should be trying to keep up with your hours."

I firmly believe this is the most healthy and productive for most people. A few people live to work so you might as well let them while trying to insulate your normal folks.
https://news.bloomberglaw.com/white-collar-and-criminal-law/...

https://firearmslaw.duke.edu/2021/12/bump-stock-ban-heading-...

Bump-stocks remain a public political issue, likely heading to the Supreme Court.
All I can say is "wow". I immediately posted to /r/itrunsdoom.
When you can have Authenticator Chrome extensions [1] what is the point of 2FA? Who decided making it harder to login for an average user is worth the added security? I'm not arguing security is not improved. The question is who weighed the pros/cons of 2FA and decided the entire industry should adopt it? Can we shine some light on the orgs/individuals responsible for this.

> This article is written like a personal reflection, personal essay, or argumentative essay that states a Wikipedia editor's personal feelings or presents an original argument about a topic.

Wikipedia describes 2FA very matter of factly without any background on its history and its advocates [2].

[1] https://chrome.google.com/webstore/detail/authenticator/bhgh...

[2] https://en.wikipedia.org/wiki/Multi-factor_authentication
I'm going to sound like one of those fanboys but Rust really is a breath of fresh air. Lots of people now are starting to make actually fast and performant applications due to the ergonomics of the language being more high level than something like C or C++. It's actually my favorite ML type language, I've use OCaml to a large extent before but with Rust, the DX is still pretty nice, even if you have to contend with the borrow checker.
Glad they brought up oxidative stress. It could be a simple fix for some people. We know many of the pathways and nutrients needed to reduce oxidative stress. Manganese, zinc/copper, B6, Riboflavin, Selenium, Vitamin C are just some of the deficiencies they could start investigating.
Sometimes you have much more, just in a different account.
FPGA's and Haskell are two topics I'm very fond of, but I would never have expected to see them used at the same level of the stack.

That's gonna be interesting.
Conviction rates are much lower with a jury than a judge.
The best thing you can do is to make friends with as many people as you can and make sure you don't lose contact. As you grow your career you'll be happy you know them.
Life is weird, I was just using this site yesterday to do some electrical diagrams for a wiring harness I am building for my ancient mobile.

My trouble was understanding how to flow something through a series of relays, and implementing "AND" and "OR" logic with a relay series.

if(AC && Temp > 160) { run both fans }
if(AC || Temp > 160 { run both fans at reduced speed }

Now, the AC is already a relay, but you can just do 'and' and 'or' together without a extra set of diodes.

Anyway, falstad, I love your CircuitJS. I wish I could drag items around though, as for me the hardest part of making sense of things is having a good clean layout.

Random question to readers: does anyone know of a tool to generate the very nice wiring diagrams you'll see in bently and other automotive manuals? I imagine they were originally by hand but later were done with a CAD tool. Just wondering if there are any good open source options.

CircuitJS fails there because I want to create objects, like a 4 pin relay, that has pinouts numbered (87, 87a, 30, etc get reused a lot!) and have colored cables (because they're colored in real life!).

Anyway love this
Excluding "Spacewar", Pong is the first "classic" arcade game that has reached the milestone of being 50 years old.

https://en.wikipedia.org/wiki/Timeline_of_arcade_video_game_...
I think all of those should be legal. Fully automatic weapons are already legal, they’re just insanely expensive (~$15K for a full auto machine gun) and require a bunch of NFA paperwork to take legal possession.
That is gun deaths, not gun homicides or mass shootings. Around 2/3rds of gun deaths are suicides. A suicidal person will choose the most effective and painless method available to them, so if they have a gun around, they'll use it. This is a totally different problem than gun violence, but many activists will conflate the two.
WasmCloud Capabilities Are Managed Algebraic Effects for WebAssembly Functions
NReal Air Releases in UK
The whole GitHub permission/scope areas has been a big issue for a lot of 3rd party developers for a very long time now: https://github.com/dear-github/dear-github/issues/113
I grew up in the UK, before I moved to the US. In the UK, I was taught that a solid punch was the solution to bullying. I fear the issue in the US is just a very disturbing take on a solid punch. You're relentlessly taught through film and media that a good guy with a gun, probably crawling through an air duct, is that solid punch. I was taught to just hit them. In the face. On the nose. Even if you lose, just hit them.

I fear this message has lost something in translation.
San Jose, Calif – November 18, 2021 – Lacework, the data-driven security platform for the cloud, today announced it has raised $1.3 billion in growth funding at a valuation of $8.3 billion. With this capital, which is the largest funding round in security industry history, Lacework will continue to invest in rapidly scaling its business globally, building on recent momentum of more than 3x year-over-year revenue growth, a 3.5x year-over-year increase in new customers, including LogicMonitor, Hypergiant, Sprinklr, and more than 3x year-over-year employee growth worldwide.

If a bit of inflation and modest interest rate hikes is enough to lead a company to lay off ~20% of its workforce after raising 1.3 $BILLION less than 6 months ago, then this company must be a total mess.
Something like StarCraft, but each unit has to be piloted by a human (using a first person shooter interface). The leader player sees the traditional high-level StarCraft interface, and directs the troops. Each individual troop sees some on-screen representation of its “orders” (“attack this unit”, “move over here”).
The Steam 2FA generation has been reverse engineered and you can use it in some password managers. Hardest part is extracting the secret

https://bitwarden.com/help/authenticator-keys/#steam-guard-t...
You can use Facebook as a flat public forum if you want to. It works fine for that (and even allows for nuance), although most users restrict most of their posts to friends.
Are they paid by the hour? Is it possible that there are multiple developers working as a single employee?
I'm assuming you're asking about ejecting the electrons and remaining positively-charge hydrogen ions separately, since keeping the hydrogen around would be a waste of mass.

I'm no expert at space propulsion, but I think this would have a few issues:

- Hydrogen has a pretty high ionization energy, even higher than Xenon

- As you said, static charge buildup

- Momentum = mass * velocity. Electrons have 1/1836 the mass of a proton, so for the same momentum you need a much higher velocity

- Imparting velocity is harder for low-mass particles because they tend to zoom off very quickly if not contained