skysight-inc/HackerNews huggingface dataset:
Disclaimer: I’ve spent my career across oncology R&D and commercial roles, but have never worked on oncolytic viruses.

Title is misleading - this is a first in human, safety/dose-escalation study for this particular oncolytic virus. Oncolytic viruses have been in clinical development for quite some time. In response to the predictable “let us know when it works in humans” responses we see following sensationalist clinical research headlines, in 2015 we actually saw an oncolytic virus approved in the US: T-VEC for inoperable melanoma [0]

A few interesting things here from my point of view. First, they’re engineering the virus to infect cancer cells and overexpress PD-L1 to prime for enhanced immune-mediated killing. This could help a “cold” tumor turn “hot” by remodeling the tumor microenvironment. Second, the virus will also overexpress a symporter in the cancer cells which allows for targeted imaging and monitoring of tumor activity and cell death. There’s a nice graphical abstract available for reference [1]

Importantly, they’re assessing this in TNBC as it is associated with a very poor prognosis and has been validated as responsive to anti-PD-1 immunotherapies (eg, Keytruda/pembrolizumab)[2]

For the curious, there’s a preclinical Nature paper from June 2021 describing this in pancreatic cancer cells [3]

[0] https://en.wikipedia.org/wiki/Talimogene_laherparepvec

[1] https://pubmed.ncbi.nlm.nih.gov/35118191/

[2] https://www.nejm.org/doi/full/10.1056/NEJMoa1910549

[3] https://www.nature.com/articles/s41417-021-00350-4
My point is who knows who “pilots” a drone if it is all remote? There could even be an Ukrainian in the middle for show.
To survive a deer could be engineered for. The bigger issue I see is people wanting to one up in size against other humans in their cars.

Everything is a damn "SUV" now despite it not being for Sports or Utility. What they are is taller and heavier which gives people reassurance. But once people see other vehicles are taller and heavier, well now they want something to match to protect their family in the event of a crash.

I don't know how to stop this cycle.
1kW portable battery, connected to a 100w solar panel, should guarantee you indefinite power in most places.

Just a 1kW battery should easily be enough to power an M1 Macbook for a week's worth of work.
Details: $600 hardware, $100 tax+shipping, $135/mo, you can pause and unpause service.
In my experience a QA is to an engineer what a nurse is to a doctor. They take measurements and can have a good eye for what might be going on, but they don’t know the code. A QA automation engineer is more like a nurse practitioner.

It doesn’t mean they aren’t smart but if they could write code they would, unless you’re working somewhere that compensates QAs and engineers the same (which I’ve never seen). Had a QA coworker try to learn to code and he just couldn’t quite get it.
> If I need a for-loop, I'll write my own script to generate the JSON.

OK, so you are using some service that expects JSON to config. You have a script to generate the JSON. Now you gotta make sure to run the script on changes. You also need to check in the JSON into your VCS despite it being a generate artifact. This leads to the perpetual "somebody fixes an issue in the artifact, and it gets wiped after someone uses the script" issues.

What you're saying is theoretically very good! But it doesn't play well with the combo of assumptions made everywhere in hosted services and some PL infrastructure:

- every project is 1 git repository, and vice versa

- commit security is an all or nothing proposition (so it's hard to have permissions like "this file can only be edited by this user" or "this commit can be made directly to `main`, _if_ it only touches this file")

- configuration as configuration

- version numbers have to be written into code

And obviously this is a problem, because everyone keeps on inventing YAML-based programming idioms for each of their services! Because static configuration doesn't map to even the simplest of setups very well.

People come and them mention stuff like Dhall. But really people want to be able to write programs that read files, make HTTP requests, and then make decisions about what to do based on that. And things like "if this test suite fails, do this other orchestration". The ideal CI flow is not staticly definable at the start of execution!

There is a killer protocol out there, and it's ... something like Skylark, with a standard library that gives file reading, checking of statuses, probably HTTP and the like.... and an executable that allows for configuring permissions in certain ways. The bonus would be just re-doing Bazel but with less guardrails. If someone showed up with CI/CD that was more in this vein they would become the dominate CD host very quickly in my opinion.
Do you know of a good source of info?

> recent data has shown an uptick of lifetime drug use and an increasing trend of drug deaths

Depends on the numbers, of course. But I think that is what folks realistically should have expected. Most societies tolerate the same with alcohol.
And the supply crunch is getting better (you can buy an RTZ 3080 at MSRP now!) and technological progress doesn't seem to be slowing down. If the rumors are to be believed, a 4090 will be close to twice as fast as a 3090.
Looks interesting.

I’ve been using MAMP Pro.

Docker works fine, but I’m not really a backend developer. I work on the server, maybe once every three months (or less often). I usually just end up using BBEdit and Forklift, as it’s a short job, and I want to get back to Swift.

I usually need to set up Docker all over again, since I didn’t keep it up, and MAMP is an overcomplex mess. The latest release did something to PHP 8, which I haven’t been able to pin down, but it’s made it worthless as a testbed, until I get that fixed.
> Yes actually, subconscious bias due to historical prejudice does have a large effect on society.

The evidence for implicit bias is pretty weak and IIRC is better explained by people having explicit bias but lying about it when asked.

(Note: this is even worse.)
I think in some part you had it right that it differs a bit by specialty, but I think the bigger part of it is that the syntax doesn't mean much without the concepts behind it. Notation is a way to compress concepts that are already understood in elaboration.

Being able to recognize notation without the conceptual underpinning might be useful in directing you towards what you need to learn for a particular task, but it's going to be difficult to learn without anything to hang it on. That said, maybe what you actually want is a math notation OCR that can direct you to documentation for possible interpretations.
Oh! I see how that's ambiguous. My "relief" was ironic in that I didn't feel obligated to note that Bridgewater has done this for years, and that it appears to be one of Ray Dalio's proudest accomplishments. In a world of terrifying billionaires, Dalio seems like a quirky one who's mostly harmless, and I appreciate that.

I think it is an interesting concept, but a dystopian application.
If something may or may not be there, that should be a clear part of its type that the compiler checks you handled (even if it's just you deciding to panic, because sometimes that's the right thing to do). Then there can be a type for just the thing, no hidden possibility of it not being there that you have to check for, and almost all code can be written for the type that is guaranteed to be there, with only a little code dealing with only possibly-there values.
Maybe. Or the language will fall into obscurity and everyone will just use the C compiler.

I'm ignorant to the history here, but GCC includes Fortran, Ada, and D compilers, right? I don't see widespread adoption of those…
Here is the original article with similar title: https://news.yahoo.com/first-human-patient-injected-revoluti...

It obscured the link to the actual clinical trial.

Also front page of Reddit: https://www.reddit.com/r/worldnews/comments/uvplpj/first_hum...

AMA with creator of vaccinia oncolytic viruses here: https://www.reddit.com/r/worldnews/comments/uvplpj/comment/i...

Thank you for the work you do.
Such comments aren't obligatory. Comments that are purely memes or jokes don't belong as top level comments (if at all).
Currency’s is not wealth , most wealth is not stored as a currency or cash [1] it is stored in assets.

If you see how actual physical cash [2] i.e. dollar bills ownership then it won’t be distributed in a typical Pareto curve.

If I don’t have access to notes and coins. I won’t use them so government makes sure I have access . They still will mint it even a at loss like the penny.

Also all power distributions are not Pareto distributions, bitcoin is lot steeper than the standard ones used in economics , that is what this article implies /shows in its analysis .

——

[1] including other cash equivalents like bank accounts not just literal printed money. Accounting standards has well understood definition of cash equivalents

[2] comparing against only physical cash (M0) because there is finite fixed amount of bitcoins available at any given point It is not possible to increase bitcoin M1/M2 supply like with fractional reserve banking so you cannot compare against narrow money let alone broad money(M3/M4)
> ...it turns up in Philippians 3:16, where the writer says that:

> "You don't race to get to the goal; the process of racing itself, of keeping the pace, is the real goal.
When I go on vacation, I like to enjoy the drive."

> In Christian churches I am least impressed by a sermon that talks about how marvelous heaven is going to be at the end. To me that's not the message of Christianity. The message is about how to live now, not that we should live in some particular way because there's going to be pie in the sky some day. The end means almost nothing to me. I am glad it's there, but I don't see it as much of a motivating force, if any. I mean, it's the journey that's important.

---

This is Philippians 3:16: "Only let us live up to what we have already attained."

It's hard for me to connect that to the paraphrase given above. Furthermore, the previous few verses (12-14) of that same chapter seem to be more goal-oriented, than process-oriented:

"Not that I have already obtained all this, or have already arrived at my goal, but I press on to take hold of that for which Christ Jesus took hold of me. Brothers and sisters, I do not consider myself yet to have taken hold of it. But one thing I do: Forgetting what is behind and straining toward what is ahead, I press on toward the goal to win the prize for which God has called me heavenward in Christ Jesus."

Also see 1 Corinthians 15:19:

"If only for this life we have hope in Christ, we are of all people most to be pitied."
It could have been wrong, but main argument was whether SQL was a good language for retrieval or not, and for me that's a no. It's probably subjective though :)
Apple in talks to buy EA gaming, Disney and Amazon also potential suitors
It doesnt matter. by weaponizing the dollar repeatedly, biden has made the world turn the world against any US technology. 135 out of 165 countries in the world rejected US call for sanctioning Russia.

George Bush: Sorry I killed 500,000 people for absurd reason in Iraq. "hahahaha".

Russia: we dont want missiles on our door step and we will invade.

"russia hur durr, putin eats babies, has cancer , rabid shriekings"
If you say so. Fortunately I'm not in charge of community relations. Looks like the person who is just took to twitter to complain, generalizing this discussion to American culture.

https://twitter.com/croloris/status/1528807119402713088

> Peak american culture when HN commenters only read the title of a submission and act surprised when you refuse to spoonfeed them information present in the second paragraph of the linked article."

For the record if the complaint is about me, I did read the blog post before commenting, and I happened to already have the context that Zig has a nice C toolchain. But I'm stunned that someone with that title is responding in this way to people who are surprised about that and saying Zig's website points it out, when it really doesn't very well. And then generalize to complaining about American culture. That escalated quickly...talk about alienating.
Too cartoonish?
I am using a low code/no code tool for some back office services and we're investing into the enterprise version. The enterprise version is on-prem only. To migrate from cloud to on-prem, we have to export the cloud data to the on-prem service. Each "section" has a download to json button but there is no download all button. So we have to go to all 50+ sections, click download, upload to our on-prem server, and click in a few places to "reset" things.

The fact that these guys cannot build a migration button smells like major technical debt. These guys aren't stupid since they have built an incredible tool. Somewhere along the line, their product became fragmented enough, where it would be too costly to build a feature that would lower the barrier to entry for their enterprise service. We're talking about high 5 figure to a low 6 figure yearly contract. They're telling us we need to go click for an hour to do the migration.

So if you don't think this is technical debt, I'm curious as to your interpretation of the situation.
I unfortunately cancelled my Starlink preorder because they raised the monthly price (because of inflation???) and the equipment cost (because of inflation, this one is more understandable) suddenly and despite my first day preorder I had still not received my unit over a year later.
This made my morning, thank you.

Personally I cannot wait for these “engineers” to be treated like normal technicians.

The odd sense of superiority that people like OP seem to have is nauseating.
I remember reading through books teaching wordpress and all of them had a variation of the line to not to go trying to change or tinker too much with the inner files that make up wordpress. It kind of reminded me of how the obelisk aliens from the 2001: A space odyssey’s sequel 2010 tells humans that they can have everything in the solar system except Jupiter.
I doubt that addicts would just chuck their drug if they found it was contaminated.
Garden myths is a great site. Here is another similar article on how to determine when gypsum will work: https://www.ccmaknowledgebase.vic.gov.au/brown_book/07_Gypsu...
Made me curious to research the Intellivision CPU, since I also had one way back when:

https://en.wikipedia.org/wiki/General_Instrument_CP1600
>> Sane languages have pointers which either can't be null or require you to check explicitly. Rather than leaving it to explode at runtime.

> Tell me more about these unexplodable languages.

I don't think anyone else mentioned an entire language being unexplodable, just a pointer type.

Later on the thread you talk about `Option` in Rust, which is not what I think most people would consider a pointer type, but even if it is, it's certainly not the only one. I think GP was talking about the basic reference type (i.e. `&T`), which will not ever be null in safe code, so dereferencing it will not explode.
You really are not helping that cause.

As a foreigner[], your point confused me anyway, and doing a Google for cultural stuff usually gets variable results. But I did laugh at many of the comments here https://www.reddit.com/r/TooAfraidToAsk/comments/ufy2k4/why_...

[] probably, New Zealand, although foreigner is relative
There is already an aviation and Maritime mobile antenna unit in beta test. I've seen photos of it. You can also see the prototypes of the flush/conformal mount aviation terminal stuck to the side of some of the starship prototypes.

The units that exist right now are meant to be relatively low cost and compete with consumer geostationary vsat terminals.
Except their network is extremely limited in capacity. 4G/5G is a much better solution for 99.9% of use-cases. Starlink is better for the extremely rural locations where installing a tower just isn't feasible.

I have a pretty rural property and there are areas nearby that get 5G UW with speeds in excess of 1Gbps. Most of the area is covered by 4G with download speeds of over 40Mbps.

5G is already replacing wired home internet for many people. Give it a few more years to expand coverage and I bet 5G will make Starlink obsolete for most of its US users.
IIRC, it only became unbearable once HOme Shopping Network and extended infomercials became a thing. Before that, there was more scripted content even if it was just reruns.
I hope future iterations can dodge these painful cliches.
This kind of comment usually comes from someone very young, or maybe unfamiliar with the state of many family's lives in the US.

Parents aren't often educated well themselves. They don't know how to teach anything to anyone.

Some of the working poor don't even have time to cook their kids reasonable meals.

Locally we're experiencing a bus driver shortage (more like a pay shortage), and the school district knows that on days without buses... some kids don't show up because there's no one home that can take the time off of work to bring them to school.

Parents with the education, time, and money can educate their own children. Outside of the upper-middle class... it's rare to encounter parents who have all of those.

If we were to rely on parents for education, we'd be setting half the country back by a good 50 years. Literacy rates would absolutely plummet.
>Well, here in San Francisco you can access both relatively easily.

It's no surprise that San Francisco is attractive to a certain kind of lifestylist. But when you look at the country you have 2 million addicts and only 400k on methadone. I find it very hard to believe that the average methadone clinic is running at 20% capacity.

https://www.healthaffairs.org/do/10.1377/forefront.20190920....
Whats "EA gaming"? Is there a non-gaming division of EA?

And Apple does not do "mergers".
A carrier can travel ~700 nautical miles in a day, which would be around the width of Texas. That is not a small area to search, ~1,539,380 SNM. Obviously you could narrow it down based on where you think the group is travelling to, etc, but if they are trying to not be found, day old data puts you in a tough position.
It's like finding a needle in a haystack. Find an extremely tiny object (relatively speaking) in millions of square miles of ocean.

A carrier is fast. 30+ knot speed, likely more (top speed is classified.) Going with 30 knots gives you 720 nautical mile radius of action, or 2,156,746 square miles.

This is to say nothing of the satellite's capabilities, or the back-end systems needed to find objects in the photographs.

There's better ways to go about it though, and the open source satellites taking photos are probably the worst for this job, to be brutally honest. But some examples:

The Soviets use to fly radar satellites to search for US carrier groups. https://en.wikipedia.org/wiki/US-A

The Chinese are suspected to have their own satellites for this purpose, though they are passive in nature, searching for electromagnetic emissions from the ships: https://en.wikipedia.org/wiki/Yaogan (Look up EMCON on how this is countered.)

But in short, it yes a carrier can still hide, though it's tricky. And this is without active measures being taken. And the Carrier Group Commander will have intelligence notifying them of when the overhead passes are. With that, they can start piecing together what the kill chain looks like, from getting that data down to the ground, the time it takes their analysts to find the carrier in it, get that data to command, and then down to the assets to take action against it, plan a sortie, and get the weapon out to where it is...during all that time of which the carrier is free to maneuver and take other counter measures. It becomes a game of cat and mouse.

It's rather dated now, but the classic book "Red Storm Rising" illustrates some of this and how it plays out.
> Mainly because there doesn't seem to be an optimal language in any meaningful way. Communication seems to work fairly well regardless of language, so it doesn't seem like optimising the language itself really solves any meaningful societal problem. And if there's no clear advantage for one language over another, then people are going to stick with their own.

Why is this the case? The same certainly can't be said of, for example, markup and programming languages. C and Python express ideas in very different ways, such that you could not reasonably say that ideas can be communicated equally well in both languages, or that there's no clear advantage of one over the other in a given problem domain. There are indeed some programming languages that simply make it harder to program almost anything you'd want to write, like Cobol, Assembly, or Intercal. Is it really true that natural languages don't have analogous comparability in terms of ergonomics and expressiveness?
No. CF33 appears to be a chimera of nine viruses: six strains of VACV, cowpox, rabbitpox, and raccoonpox created in monkey cells[1].

Seems to be mostly vaccinia (VACV)[2][3].

[1] https://pubmed.ncbi.nlm.nih.gov/29988502/ page 18

[2] https://www.cell.com/molecular-therapy-family/methods/fullte...

[3] https://www.nature.com/articles/s41417-019-0114-x
Fastest passenger jet goes supersonic in tests
The "just decriminalize" narrative about Portugal is a lie.

https://twitter.com/shellenbergermd/status/14153458369139220...

Portugal has humane, coercive policies to get people off drugs, public use is illegal, and people get arrested.
Starlink architecture right now is up and back to satellite as a bent pipe, satellite needs to be simultaneously in view of your terminal and a starlink earth station while it is moving. This means mid ocean won't work yet.

The satellites they are launching now do have satellite to satellite laser links, but this is not been implemented in production yet, and there are nowhere near enough polar orbit highly inclined orbit satellites in operation. 95% of what's orbiting is in about a 53.2 degree inclination.
Skydiving salamanders live in world’s tallest trees
Doubtful! Plenty of places in Los Altos without service. SIGH.
> Dunno how much you can get out of RV solar panels on a good day though.

As much as any other solar really, it just depends on how many panels you can put up there.
This is the worst sort of hn pedantry, but I have to agree. The security premium paid by cartels down through street dealers is indeed real, but QC and regulatory compliance would eat a lot of that savings. And the executive tax at cartels is probably similar to public firms.
> Include TOTP one-time-password login in the core. (I hate having to deal with plug-ins.)

What's everyone currently using for this?
averages 48 to 74 watts for the rectangular antenna
It's hard to say because even a model like GPT-3 is limited in its ability to generate a textual story that remains coherent over time. When you're talking about generating video, you need to have lots of story and visual details remaining coherent over a very long time horizon. Generally speaking, I think this is an area where deep neural networks are fairly weak and symbolic AI shines. It's much easier to program a symbolic AI that generates a story that remains coherent over time. Though you might argue that the story probably wouldn't be very interesting. There's probably something to be done with a hybrid model that uses symbolic AI to enforce coherency constraints, and a deep network model that fills in details and generates visuals.

So yeah, I think we'd need new, much more sophisticated architectures. We'd also need a lot more compute, like 10x, 100x or maybe even 1000x more, to generate high-resolution video. Actually, the problem is probably not the amount of compute you need for inference, but the amount of compute you'd need to train a model with hundreds of billions of parameters or however much is needed to make that happen.