skysight-inc/HackerNews huggingface dataset:
Caution: While this is a cool study in Nature Neuroscience, almost all facets of this work are based on a single fully inbred strain of mouse—-C57BL/6J. This strain also happens to have a major mutation in the GABRA2 gene that reduces expression about 2X relative to almost all other strains of mice. GABRA2 is one of the most important receptors involved in inhibitory responses in CNS and benzodiazepine responses.

This same strain also has a well known splice variant mutation in a key mitochondrial gene, NNT, that modulates both mitochondrial and macrophage function. The microglial mentioned in this paper are a special class of macrophages that reside in the CNS.

Given these comments, when the authors refer to “wild type” (WT) mice, remember these are anything but true wild type mice. Fully inbred strains always carry numerous homozygous recessive and dominant mutations (several hundred each) that often affect CNS, immune systems, and mitochondrial functions.

The results may well hold up in other strains, but I would not count on it. Do benzodiazepines affect all humans uniformly?

Would studies of other strains or types have been practical? Yes. The Thy1-GFP and Thy1-YFP lines can be crossed to make F1 hybrids. This particular transgene is also available on at least one other strain of mouse (DBA/2J).

Unfortunately, most reviewers at Nature Neuroscience are not geneticists ;-) They are typically strong molecular neurobiologists who are used to reductionist methods. They are perfectly content with submission to Nature journals that are based entirely on with N=1 mouse genome—almost always the mutant C57BL/6J inbred strain.

In my own work I try to avoid this N=1 trap. (But I have also failed ;-)

Generality and robustness of results (see quote below) should ideally be established across two or more diverse genomes before making broad claims of relevance to other species, including od course to humans.

The quote:

“We have demonstrated that microglia in WT mice alter their morphology and functions upon diazepam treatment and cease to do so in Tspo−/− mice.”
And yeah, everyone used the same instrumentation library, which could be used in a lot of different contexts, sometimes surprising!
Starbase' ultimate tour guide Elon Musk
Perhaps if you were poorer or of a disfavored ethnic group, observation would show you the abuse that happens with them.
> Obviously CICO is a thing inasmuch as it's a thermodynamic process. Those people who parrot it though aren't really using their brain and are trying to simplify a complex human process down to "eat less".

Speaking for myself, the reason I often parrot the Cico advice is because it's become "common knowledge" that Cico is wrong, which is ridiculous.

Three years ago I would parrot all the usual anti Cico talking points, about how human fat gain is far more complex, there are good calories vs bad calories, hormone response matters, etc. Then when learning more about this, I eventually understood that really, if I count calories and start eating less, I'd lose weight.

I'm not f that explicitly counting calories is the correct strategy for everyone to create a caloric deficit. Your points are absolutely valid.

But after I lost weight, I've had multiple conversations with people insisting that the only thing that could work is cutting out carbs, or only eating meat, or intermittent fasting, etc. Those are great strategies to try, but it's fundamental to understand that they're only strategies to induce that caloric deficit. Otherwise you are setting up for eventual failure.
In Childhood's End, Arthur Clarke wrote:

"No utopia can ever give satisfaction to everyone, all the time. As their material conditions improve, men raise their sights and become discontented with power and possessions that once would have seemed beyond their wildest dreams. And even when the external world has granted all it can, there still remain the searchings of the mind and the longings of the heart."

A century ago "harsh truths" pushed child laborers into mines and mills. Those whose minds are searching and hearts are longing also need intangible benefits for which "What You Are Inside" very very much matters, despite the reality tunnel of the Cracked Philosopher. Great parents and teachers know this.
It really isn't ERCOT, it's the Texas government that is the problem. ERCOT has -very- limited power over things. They have very limited power over the power providers in the state.
As of 23:35ish UTC there appears to be a glider on the board.
Shaped charges are also used to create the holes (perfs) in wellbores prior to fracking. The shaped charges blast through 1/2 inch of steel pipe and then a foot or two of rock. Sand and water are then pumped through the holes to prop open the rock and allow oil, gas, and water to flow out with less resistance.
Here's some links relating to this style of code that you may find useful:

https://docs.google.com/document/d/1W83ME5JecI2hd5hAUqQ1BVF3...

https://github.com/tlack/b-decoded

https://chat.stackexchange.com/rooms/90748/conversation/ngn-...

They're not 1.5 paragraphs per line, but enough to give a taste of the implementation style.
CNN accidentally sent welcome baskets to employees who had been laid off
I saw a couple of bots fighting over the same land, immediately drawing over each others lines, which was fun.
I'd imagine the types of rocks would matter. There are also a lot of ores that should remain in the ground, and not pulverized and spread, contaminating water and soil.
> if you want to give his point a generous interpretation

No need to be generous, it's a centuries long historic fact.

https://en.m.wikipedia.org/wiki/Violence_against_LGBT_people
Depends your threat model.

The simplest solution is to have a centralized clock that everyone trusts to digitally sign the document that it was created at x time. This can be verified offline with the clock's public key. If you need to be offline at the time of creation, then blockchains won't help you. Best you can do is have every participant sign the document that it was created at x time.
There’s not really any reason to grow crops on the moon though. A lunar base could be useful but never a self sufficient settlement of any sort. The moon cannot support a real atmosphere.
If the chance of winning at trial is, say, 75%, It’s extremely likely the suit will be backed by investors, since if you back hundreds of suits, the impact of being unlucky goes away.

There are many hedge funds, public equity firms etc. with easily as many resources as an average mega-corp.
Why does every website need a distinguishing feel? Does every published book try to come up with a new typeface?
It’s extremely rare for this to happen.
Linux keeps computers up to date just fine without subverting user's interests constantly.
Forced redistribution of wealth is dysgenic, and there is no single greater indicator for success in life than IQ.
> Putin coup is underway and 'impossible to stop,' says Ukraine's military intelligence chief

You left out a very important piece of the title, unless the article updated it after you posted.
Texas grid is big enough to do fine on it's own. The problem is that power providers (and gas companies) are given the upper hand and never had to winterize more than a token amount, hence the house of cards came down last February and around 500 people died as a result. The Texas lege passed an "oops" bill that put on a couple bandaids, but the same thing is bound to happen again with the next big Freeze comes along.
First steps can be to use git diff and select what’s changed. Bulk of the heavy lifting will still be responsibility of ORM (sqlc). Later on this experience can be streamlined.
Probably a sort of crunchy effect, but hey it's high in minerals
Yeah in theory people could do their own custom bucketing functions. Would be worth researching log-linear for that certainly.
Currencies rise and fall, and US dollar may as well get replaced by the Chinese yen as the world reserve currency by 2050. But that does not in any way merit cryptocurrencies, whose uselessness is independent of the failures of the US monetary policy.

Your argument reminds me of the Politician's fallacy, which goes like: "we should invest in an alternative asset in case the US dollar fails, cryptocurrency is something, thus we should invest in cryptocurrencies." Go read this thread to understand the numerous criticisms of cryptocurrencies and then think why any of the existing cryptocurrencies should be worth beyond $0 (or slightly more, I admit they are novel and thus could be a collectible).

[1] https://en.wikipedia.org/wiki/Politician%27s_syllogism
While on vacation recently, I gave my iPhone to the tour guide while he talked about the towns history. I had my AirPods in with Live Listen so I can chase around my 3 y/o while still listening to the guide. They work exceptionally well for that
100 in Texas is hot no matter what time of year it is, despite the claims, especially in the more humid parts of the state :)
You should probably read about the pharmaceutical industrial complex to balance out your wildly biased and one-sided, unbalanced perspective.

Are you honestly going to claim that the many multi-billion dollar pharmaceutical industry doesn't have a financial incentive to lead people toward 1) daily use medications that gives the industry a monthly recurring revenue stream, 2) where many people on them long-term because many of them have severe withdrawal symptoms so they are very hard to get off of?

And then something like 80% of ad revenue of mainstream media in the US comes from the pharma industry - so how do you suppose that influences what news and narratives are shared or allowed to be shared to the majority of a population on the mainstream-mass media channels?

You conveniently also forgot to mention that SSRIs, for example, actually increase the rate of suicide (along with suicidal ideation) - so you're more likely to kill yourself if you take them then if you didn't take them; that is from their clinical trials. It's the elephant in the room that's been mostly suppressed from conversation for some reason, somehow - probably in large part look at my previous paragraph for one mechanism used.

Are you also claiming then you know "more than just enough about pharmacology" in order to give a more credible response? Or are you perhaps arrogant thinking you're more competent to respond - but perhaps instead you're just indoctrinated into a biased perspective? Do you work in the medical profession, perhaps even one that prescribe medications? Consumers are bombarded by propaganda, and professionals even more so.

In reality you probably don't actually have any idea what level of knowledge nor experience the person you're responding to, saying that their response is dangerous.

Reality is more complex than you're currently aware of.
the messages app
FIDO is strictly better: with “password” you share your email + password with the server. If you use the same password on another site, the server knows your password. You may trust the server, but in case of a leak you’re doomed.

With FIDO you share email + a signature that doesn’t reveal anything at all.

Privacy aside, the FIDO signature also protects you against phishing as the (hostname of the) url that’s displayed in the browser is part of what it’s signed, so an attacker can’t reuse the signature to log you on a different domain — unlike the password (and other 2FA like otp codes) that can be phished.
KDE connect, from my understanding, is almost more of a protocol than needing the KDE Desktop manager. I've actually never used KDE Connect on a desktop yet use GSConnect on gnome, Soduto (https://soduto.com/) on mac, etc.
It's good for engagement. Get everyone talking about the latest Netflix controversy. Release Cuties and piss off all the stupid uptight conservatives who don't understand it's just a coming-of-age story, then release a Chappelle comedy special and upset all the right-thinking leftists who don't understand it's actually pro-trans.

Then no matter whether you go to get your daily Two Minutes Hate in, all you see is NETFLIX NETFLIX NETFLIX NETFLIX NETFLIX everywhere.
How much was that? about $40k?
Whatever it takes so that nobody in America has to make any substantive changes in their way of life.
Newer studies have put doubt to olivine's effectiveness: https://www.technologyreview.com/2022/03/30/1048434/why-usin...
Not sure how "Propranolol may cause heart failure in some patients" is considered safe.
What? Planet scale? Well. You can literally issue a query that fans out to every continent on Earth, and returns the result right to your dashboard. Not exaggerating. ;^) (OK maybe not Antarctica but I'm not sure...)
ironic that Norm was the one who died, I guess we know what makes the other guy "special"
If this kind of story intrigues you, take a look at the 2018 video game "Kingdom Come: Deliverance", It is an RPG that centers around a region with silver mines in the Kingdom of Bohemia in the early 15th century.

The area these silver coins were found in was once part of Bohemia, and less than 200 km from where the video game was set.

https://en.wikipedia.org/wiki/Kingdom_Come:_Deliverance
Sometimes efficiency and just-in-time production come at the cost of decreased robustness. A maximally optimized system has no slack.
Elon Musk says Twitter legal team told him he violated an NDA
A normal soil ecosystem has fungi breaking down rocks to gather nutrients and sometimes exchange with plants. It could be a sort of fertilizer but certainly there would be a point of over applying which would have to be understood.
Everything beyond the introductory matter is available only to subscribers to Taibbi's Substack -- who presumably have already been notified of this without needing to see it on HN.
Here's a study that found that the olivine hypothesis might not work as expected: https://www.technologyreview.com/2022/03/30/1048434/why-usin...
My only defense for these situations is to stop and genuinely consider whether I was being an asshole and if so, to say so loudly and categorically and apologize for the inevitable lapse in my normally mediocre judgement.
Chinese tooling engineers are highly paid
Yep, and if you know enough to set that up, you probably don't need Dokku.
Records are very new. To be honest, I haven't seen a single project that isn't my own use modern Java features. Most projects I've seen still target Java 8, some Java 11.
I remember this article from 2012. Had a major effect on my life.
As a random aside, Day of the Condor is Kevin Mitnick’s favorite movie. Mitnick was probably the most famous hacker in the world at the time Sneakers was being cast.
Sorry, the pedestal bit was not aimed at the parent comment.

I’ve just seen a confusing amount of HN users who do speak of him in such a manner & thought I would make reference to that for context.
It's depends on habit. People are not used to being actually in empty stomach since childhood.

Eating all the time makes our brain want food all the time. I did intermittent fasting and now I'm completely okay not eating during that time. For other times it becomes easy, after not eating like before.

The food doesn't have to be calorie heavy. Replace with meat, nuts, vegetable, fruits (not juice).
This business deal is far too dramatic for me to continue caring
Tylr: A tiny tile-based editor
Clearly if you are putting it on farmland, the farmer will demand the beneficial stuff and reject the harmful stuff.

There are lots of opportunities for harm, but plenty of material that would be beneficial, particularly for crops that like higher pH.

Olivine, e g., often has excess nickel, which you then would not use on farmland. You might dump that on beaches, instead. The main thing is to move a lot of it. You would prefer to use renewable electric to crush it, but the main thing is to get started.
Rene Daumal quote with a similar message:

I am dead because I lack desire,

I lack desire because I think I possess,

I think I possess because I do not try to give,

In trying to give, you see that you have nothing,

Seeing that you have nothing, you try to give of yourself,

Trying to give of yourself, you see that you are nothing,

Seeing that you are nothing, you desire to become,

In desiring to become, you begin to live.
Are you certain that a hurricane can blow a straw through a telephone pole? I hadn't heard of this phenomenon and was interested. I was unable to find a good source.

According to this article, the National Oceanic and Atmospheric Association thinks it's not possible:

https://www.livescience.com/39270-tornado-straw-into-tree-wo...

(Alternative explanation in the article: the tree twists during the hurricane, cracks temporarily open, and debris gets stuck in the cracks.)
Not only that, but I am sure you could dust off those 1200s and sell them for over $400 each. Even beaten up mk2 models can fetch that much.
Because El Salvador is a country that is in danger of defaulting on its debt. Netflix is just a company.
Lack of native Linux-like containers would be a big one, in the age of container orchestration and clusters.
They are mostly already oxidized.
- propaganda put out by competing pharma companies to smear newer medications or create distrust of them

- pharma companies who spend more to get the lion's share of ad time keep their brand at the forefront of consumers, consumers then ask for those medications and then don't know about alternatives because they've been drowned out

- arguably some of most effective drugs have been illegal the past 40+ years as part of the "war on drugs" (did pharma industry help make those illegal?): marijuana, psilocybin/DMT, MDMA, and even cocaine will knock people out of a depression - where it could be taken weekly or less (arguably potentially more addictive than other medications, but SSRIs with severe withdrawal symptom is arguably equivalent to addiction, the aversion to the withdrawal symptoms) - but pharma can't patent any of those, so they can't gain exclusive rights to a brand they advertise to manipulate people to buy or trust their brand over something else (so patented drugs can captured more revenue and have more profit to pay more for ad time to drown out cheaper, more effective competitors).

- etc.
4:40 points out the serial ports. It is interesting how serial is still a valid mode of communication nowadays...(like every microcontroller and almost every desktop motherboard still has some serial port), so could still talk directly to this.
What a ridiculous title and "article".

Imagine what the hell is going on with the rest of the food, drug and completely unregulated vitamin/mineral/supplement industry if this is what happens with baby food

> The company recalled several lots of the formula brands Similac, Alimentum, and EleCare in February following complaints that infants contracted cronobacter sakazakii, an environmental bacteria. All four babies used formula produced at the company's Sturgis, Michigan facility.

> cronobacter sakazakii bacteria was found in a number of areas in the facility, and other safety protocols, such as employees wearing gloves, were not observed

So right, the government regulation is the "bad guy" just like making people wear masks in a pandemic is the "bad guy"
They've already embarked on making one of those huge grid-balancing battery facilities here and I'm sure more will follow. Likely they're waiting for the inevitable Texas grid fuckup that's even worse than 2021 to happen so they can come bail it out and make some real infrastructure money. If they have to do some idiotic libertarian song and dance to ingratiate themselves with the all-hat-no-cattle corrupt knuckle-draggers that run this state to pull it off, they'll probably do that too.
I don’t understand why I enjoy listening to norm so much. I remember him from weekend update when I would get to stay up late before I was a teenager, and his story on david letterman about throwing mustard on the football field at the panda game while on acid. Maybe he was the first adult I heard talk openly about getting fucked up and doing stupid stuff. As a 12 year old it was an eye opener, oh you can do drugs and be successful and be on TV.

During covid I watched all the norm material on YouTube. “I’m not norm”, a YouTuber out of Seattle slanging norm t shirts uploads all the clips. I can’t put my finger on it, but there is something I love about norm. I even rewatch his talk show episodes on Netflix. Maybe it’s because he never seemed to care for the trappings of success, fame, celebrity and money, he has a humbleness that is genuine.

I recall a story where he throws $70k in to the ocean and says what’s the difference I’m just going to gamble it away anyway.

What was also interesting is the respect that he got from other comics. There was a david letterman episode with Schneider, spade, Sandler, 2 other dudes, and norm, and they all would stop to let him talk. Somehow he was the alpha comic.

His trolling of the other hosts on the view was also spectacular.

Can’t wait for this special to be released!
Missing from the reactions here is the following line:

>When diazepam medication was stopped, the effects lingered for a while but were eventually reversed.

Also when making a conclusions from this mouse model to a human is how much were they actually giving the mice… a sleep inducing dose could be small or heroic.
It's actually the default in C#.

This is, in C#, all methods are called according to an object's apparent-type, not its actual-type, by default. To get the Java-behavior, a C#-method would need to be declared `virtual` (or `abstract`), and then more-derived methods would need to choose to `override` them (rather than hide them, often via `new`).

Part of the advantage might be performance. This is, methods that go with the apparent-type don't need to do a virtual-lookup-table resolution, which can save some work in method-calls.

Another advantage is that it can help provide more flexibility in class-hierarchies, since more-derived classes can "hide" less-derived classes' methods without overriding them. It's probably not something that folks really need to do too often, but it's nice to have an easy solution when such a case occurs.