skysight-inc/HackerNews huggingface dataset:
Your utter terror of these drugs is not warranted. Yes, some of them have intolerable side effects. Some of them will just be ineffective. But there are lots and lots of different antidepressants and there is probably one that will work for you without intolerable side effects. If there isn't, then there are other options (ketamine or TMS for example - but you can't start with these, you have to try antidepressants first). It will take time to figure out, and it will be a lot of work, but you owe it to yourself to at least try, especially if therapy alone hasn't worked.

My advice is to get an actual psychiatrist. Your PCP will prescribe antidepressants, but in my experience you'll be way better off relying on the expertise of a specialist, especially if you need to sort through which medication is best for you personally.

If you should be in utter terror of anything, it's depression. It is a potentially fatal illness.

Also, seriously, don't get medical advice on the internet. Would you ask a random sample of strangers on the street to direct your medical care? I'm guessing no, but that's exactly what you've done here.
It probably would do the opposite - MLMs teach you to turn every single interaction with another human being a sales pitch. People tend to be really put off by that.
If people just wanted stats or references, there are other places for that. They (we) come to a forum to discuss stuff, so anecdotes have value. Plus in general they are easier and more entertaining to process.

I'll also point out that your question has an anecdote in it about a current front page post. This is not a bad thing, you use it to illustrate your point, same as happens in comments.

(And, your headline implies without any evidence that your anecdotes make HN readers "anti-science". This is not good)
I think you’re on to something with that. With so few round trip conversions compared to something that is charged/discharged frequently, the conversion efficiency doesn’t matter as much compared to the cost of storage.

For a given kwh of storage that is round-tripped daily, a 1% loss of efficiency loses 3.65kwh per year. For a kWh of storage that is round-tripped once per year, you only lose 0.01kwh. At 70% conversion efficiency the yearly storage still loses only 1/10 the energy as a daily system at 99%.
The stated reason was doxxing.
shout out to the travesty that was calacanis' mahalo.com[1]

[1] https://en.wikipedia.org/wiki/Mahalo.com
We have a saying in reputation management "Never let a good crisis go to waste", fear and uncertainty can be powerful drivers for drastic actions.

For example, you'll get drastically different responses if you ask someone whether they'd be willing to pay X for a panic room, or how much they're willing to spend to keep their family safe.
What are you searching for?
Let's take an imaginary country, picking a name out of thin air, lets call it Greeessss.

Let's take an imaginary broker of imaginary internet points, let's call it Gold Ball Sax.

The imaginary internet points matter to Greeesss and of course TheLittlePeople(TM), but not at all to GBS and state actors and Sluttygroup and so on.

GBS finds Greeesss particles who can sign LegallyBinding things that then disappear from the interaction at the speed of light.

It all collapses into a singularity from which only debt can escape.

The condensed matter BelieversinInternetPoints all spiral into the GBS hole, adding to its mass.

GBS never loses mass ever, because the laws of physics were written for it to happen this way.

Various blobs of condensed matter blame everyone and each other while spiralling . Nothing ever changes because the blame sent to GBS just disappears.
I think the problem is distinguishing which experiences cost what ahead of living them, and finding alternatives (which, among other things, religion is or poses as). For example, mundane day-to-day hopelessness is very costly as well, which often leads people to equally costly alcoholism…
While none of the wars was limited to killing uniformed enemy soldiers, for the vast majority of soldiers fighting those wars (even if illegal wars of aggression) their personal actions were limited to killing uniformed soldiers and they are not responsible or liable for any war crimes, as they did not perform them.
What exactly is Google supposed to do here? They're returning what's available. Beyond that it goes from search engine to active curation and recommendation - and they are actively moving in that direction by replacing results with "answers", which I find to be much worse.
Literally doesnt matter unless you have been holding since 2006. I invested in twtr in Feb 2020. Its been a ride
totally agree. trump not being on twitter is increasing any chance he has in 2024
Ability to use booleans and quotes in a standard search.
not us yahoo / Altavista / or whatever else was around at the time users. Google was so clearly better right out of the gate that I distinctly remember having conversations conveying the shock and awe at the quality of the results. Before Google everything was mediocre at best.

I’d say the for the bulk of Google’s visitors the results aren’t merely good enough, they’re insanely great.

Now, that said, the G monopoly is horrible and needs to die.
It's hard to imagine a company sabotaging their primary purpose as actively. This is such a tough situation. Every user wants to be able to update their stuff, rewrite their words. But the public function, the utility of twitter is as a system of record, a forum for interaction. Edit threatens to blow up the primary value of the network, it's attestability. What happened when.
Mastodon has this right: it's "Delete & Redraft". Start over. You don't get to keep your timestamp. When you say something is as important as what you say. Letting this blur together, destroying Twitter as a part of the record would be an incalculable loss to the platform. Yet it's something that countless users all want and demand. Technically fairly uninteresting: but this is a very hard product trade off to make.
So what? Everyone has had stories about misdiagnoses or not being taken seriously by doctors, etc. I had a condition that took a long time to get a fix until I changed my doctor and got a proper evaluation done. And that wasn't even for mental health, which the US is not particularly well known for. My doc would come in, listen for maybe 1-2 mins, prescribe some shit and leave. I had to take stuff into my own hands and drive 2 hours to another hospital to finally get something done.

Parent comment is not giving explicit medical instructions. All they're saying is "talk to a medical professional" isn't some miracle advice that always works, particularly for mental health. It's fine to give anecdotes as long as one holds them with a grain of salt.
thanks - will follow up once the dust settles!
The iPhone is a more profitable platform than iPod. Cannibalizing the iPod market was a move that maximized long-term profit.

Jobs wanted the iPad to represent a unique interface and experience that was distinct from a laptop. They failed to do that and the touchscreen is the only difference that remains. Merging these products is only likely if they doesn't reduce overall expenditure on Apple products in the long-term.
Ask HN: How is data science being used in venture capital?
Or if you aren't aware of any specific examples: how could it be used?
Unfortunately, I can't see this as anything other than a solution in search of a problem.

Everything you'd want to do in a terminal that is worth sharing would be version controlled, which is vastly superior in everyway.

You've all done some cool work here, and I can complement that, but I think this is a really weird idea with no real world evidence to justify its existence.
I agree on one hand, it's a perversion of business that seems to manifest in venture capital bubbles that growth is never satisfied. On the other hand, what are they doing with all that talent?
lol I definitely need to start season 2
Wow. Never liked Jobs but never saw that video either. I couldn't stop shaking my head yes slowly.
To any reasonable degree of precision? Difficult.
It's higher than that depending on the industry, but you are assuming that 100% of small businesses started right as the lockdowns hit. Most small businesses that make it past the first couple years last a long time.
I guess the problem with those platforms is that most privately censored speech is still the actual hate speech stuff like Nazism/racism/homophobia/etc, so those platforms have taken on all of those aspects because those people have nowhere else to go.

But Twitter is not already a cesspool of those things, and I guess the feeling is that loosening up on the reigns a little bit won't suddenly cause Twitter to turn into a neo-nazi dominated platform. You'll just have things like not banning Donald Trump or not squashing factually correct NYPost articles – which of course are things that you can still debate the merits of but are different from Twitter becoming 4chan.
I agree with everything you said. I don't agree with the "real exercise" mantra for the reasons you've stated (creating unnecessary barriers and stigma). I was probably reading into the details too much. Mainly I want people to understand that loading is safe - and encouraged - even when you're older. Load management and fatigue are essential and should not be taken for granted.
Though I agree that some of these people may have been complicit in war crimes (which will most likely never be officially recognized as such, in our lifetimes at least) -- on a more fundamental level, this post is unfortunately an instance of:

https://en.wikipedia.org/wiki/Whataboutism
Someone said it better than me, but a lot of HN users are smart engineers and are basically jealous of what he has achieved. The pile on hate of Elon Musk in here is hilarious to watch, and it happens like clockwork.
The thing that's not obvious this is that Johnson began the War On Poverty because having the lower classes in poverty wasn't politically acceptable in that time (partly because of the Cold War). In contrast, the lower classes not being able to afford rent or health care today is essentially acceptable.

This link [1] shows income inequality plateauing around 1950 and then rising sharply toward the late 1980s, reaching the levels of the 1920 at around 2010.

[1] https://www.cbpp.org/research/poverty-and-inequality/a-guide...
The Cost of Zero Covid in Shanghai
Probably a submarine story

http://www.paulgraham.com/submarine.html
Effectively, what you’re trying to do is narrow the list of causes.

It almost sounds biological only nature if it’s been this way your entire life, unless you’ve also been constantly stressed your entire life.

So what I would recommend is just trying to check off the basics. This is going to be trial and error if you’re serious about solving your problem.

A bit like making sure the computer is plugged in.

A very common cause of depression is Vitamin D insufficiency for example. I’d order some supplements and see if that helps. Followed by magnesium. Because that’s also a common cause of panic attacks (at least anecdotally).

I’m not saying this will cure you. I’m just providing it as an example of where to begin since it’s relatively common and I don’t know much about you.

Don’t give up. Make a checklist if you have to. This is going to be a long process of trial and error.
As a non native, I sometimes confuse Mar and May.
I used them with a set of Shure SE315 earbuds. I mentioned the Apple ones because that's what many people have today and are similar in price.

The fit on mine from custom insert to the Shures was pretty tight (good for air sealing). I could have drilled the holes a little larger, but it was easier to just warm them up with a hairdryer.
It's not about any twists. He himself said why it's different - he wants this particular "public forum" (as he described it) to be more as he likes it, so he bought a stake in it. I don't see why it should have any relation to his behavior in other companies. He never said he wants Tesla to be a public forum that maximizes free speech - he said that about Twitter and then put his money where his mouth is.
Actually it’s not an opinion, like saying I enjoy pizza with pineapple. It’s a completely unsupportable statement of fact.
Beautifully analog too, if you get an older one
Cannabis.

Allows me to focus on tasks and really hit flow like I can't when in a "normal" state of mind. I'm not alone in this!

I've considered trying Adderall but who wants to get addicted to amphetamines?
Supposedly he was talking to the Babylon bee just before about how they got banned. I am very curious what he will do.

He is anything but conventional, he is not there to go for low hanging fruit I don't think
That makes no sense to me, if you're trying to deal with mental health problems and struggling you're going to be looking for new ideas from any source. Doctors are good at giving garden-variety medical advice that's validated by studies, but there's so many other ideas out there that they're not going to know about. Their background gives them expertise on what medicine says about mental health, not about the human experience itself.

Anecdotally I've been to therapists and doctors that were no help and I've read an article online [1] which was a tremendous help.

[1]: https://kajsotala.fi/2017/07/how-i-found-fixed-the-root-prob...
The MLM stuff is STRONG in the SAHM community, though. I don't get any of it, fortunately, but for the wife it's every other convo at the playground.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985449/
https://www.vice.com/en/article/pkeqd8/what-happens-lsd-over...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289311/

TLDR Its thought LSD sort of mimics SSRI's and locks into the serotonin receptor, but which receptor I dont know as I havent read the article and there will be a few different one's if other receptors are to go by, like histamine.

SSRI's can affect your sleep which will affect your memories and possibly your work. If you program then not being able to remember where code is could be a problem but it might not be. Escitalopram is like doing Ecstasy (MDMA) if you drink copious amounts of black tea and sugar when on them, ie you will have little E rushes throughout the day which could send your life off the rails.
Melatonin besides being the sleep hormone is an anti oxidant and helps release stem cells and SSRI's can affect this hormone.

The older MAOI's maybe better, but OD on those and you will literally lights out and have no recollection of passing out. Popular with those looking to end it which is why SSRI's came to be. Problem with some of the SSRI's is they can also affect other parts of the brain which could heighten aggression and other less than desirable effects. You will reports of some SSRI's even on here https://www.erowid.org/pharms/fluoxetine/fluoxetine.shtml

I'd also look into the metals that make up various SOD's. Super Oxide Dismutase's they reduces Free Radicals and these can contribute enormously to stress, and other less than desirable effects in the body. Start with copper.

An inorganic Carbonate would probably be the only form of a metal I'd touch not chloride & sulfate, the others I would get chelated ie a metal bound to something like Glycine, which causes vasodilation and reduces inflammation , and happens to be the one chemical that has significantly increased the life span of rats more than anything else. It powers up the mitochondria.

I'd take a serious look at your diet though, your environment and even your sleep habits. Identify what it is that gets you down and see if you can resolve them. Easier said than down when considering how stubborn or criminal people can be which may be contributing your depression, but I'd start with diet and environment, and I'm not qualified in anything except my own opinion!
Right quick.

Have you tried the drugs?
> Yes, Ask your doctor which doctor is best for you. I took them for about a year. It takes about a month to get it into your system, this is important.

Is my utter terror of these drugs warranted or should I just bite the bullet and try them?
> Try them. Talk to your doctor. The first step for me which was the hardest, is be as open as possible to my therapist. It took me a year or so to get this going. I don't go to therapy anymore, but I am more open to those around me.

Also, if a therapist doesn't work for you, try another one. There is no reason why you need to stay with one, it is like dating, you need to find the right one.
> using up millions of VC-dollars building a new version of this fundamentally important core utility

It's nice to think of this as 'taking advantage of' VC dollars, but VC dollars come with strings attached, namely the need for an 'exit'. The exit only happens if the company in question makes multiples of what it invested, meaning that VC-funded companies need significant revenue from their users. These days, the growth required for an exit leads to: 1) advertising being laced into a product, 2) user data being sold or otherwise monetized, or 3) charging you a monthly subscription fee.

Maybe this time it's different—there are theoretically other VC-friendly business models that work for software—but I struggle to see how.

Open-sourcing the application from the beginning would certainly give more confidence here.
This is awful advice, OP, please do not listen to this.

Therapist is good, exercise and sun too but the rest is so bad I really would not know where to begin.
Finding time to work on a side project
> We need new thinking to create something much better than what came before.

No we don't. Google needs to go back to what made it successful: showing web pages that have the words you search for, untainted by SEO shit.
I am mostly following this as I am convinced this news will tank equity markets sooner than later.

But this section which reads:

"Desperate, Luo went on to the social media site Weibo to plead for help. Local media soon called him, and medical help was quickly on the way. “Thankfully, the operation is done,” he said. “It’s not supposed to be this complicated, but as a small potato everything is so difficult for me.”"

Made me think it's right up HN's alley.

Sounds almost exactly the same as trying to get any necessary help from big tech these days.
Actually Helium is what alpha particles become after they acquire 2 electrons. And alpha particles is what Radon radiates [1]. There’s plenty of Helium being produced every moment on this planet. Some gets trapped underground in pockets of natural gas. There is such a case in Arizona, where the natural gas contains 8.3% Helium [2].

[1] https://www.epa.gov/radiation/radionuclide-basics-radon

[2] https://en.wikipedia.org/wiki/Helium_production_in_the_Unite...
I feel like I need to confirm this independently... I'm going to order some pizza :)
The fact that you're comparing homosexuality to a death in the family really drives this home, doesn't it?

If someone is okay with being out (like a married-with-children couple) then it's okay to acknowledge they are gay. Just like saying Timmy's dad is a doctor is okay. A teacher shouldn't risk legal action for saying so.
You don't send a Twitter mob after people, full stop, even if they work at schools of education.
The specific communication about “police and lawyers“ refers to that as a response to online publication of private information. For criminal law enforcement, the most likely applicable law at issue would seem to be California's cyber harassment law.
Maybe this could be solved through tree pruning. The backlinks would give up every one of the scammer's scummy websites no?
As a not user of twitter, you really made me confirm my "no way, ever" stance, as far as the platform goes. With editing, as you describe it, enabled?
"Absolutely not a fucking chance", is the most polite phrase i can think of.
Imagine replying to me, me changing my reply, then you having to extra-click to wade through various re-writes i could manufacture.
There's a difference between a bear market and having your business shut down by the government.
Who is Dynomight? I have a hard time reading the work of anonymous people, because I have no frame of reference to interpret them.

May he looks like a guy who is easily led.
SSRIs are really not as powerful as it sounds like you think they are. At least in the 'regular' doses I've taken, you can barely tell they're there. You've heard stories about extreme cases, which you probably won't be. And it's better to try and find out if medication helps you than go how every many more years without knowing if that's a way out.
I think the reason you are getting so many "I disagree" responses is because many of us have had awful experiences when it comes to medical professionals and mental health.

It's important to understand the economic pressures in psychiatry. I went to see a psychiatrist, who prescribed me antidepressants. They helped give be a baseline level of energy to get me out of my acute depression, but they addressed none of my underlying issues that caused me to get depressed in the first place, and a couple years later I was right back in the depths again. And I'm fine if my dr's economic model meant he couldn't do psychotherapy with me, but he never recommended I get therapy, and that's what I'm so bitter about regarding him.

I've heard it said that giving antidepressants to a depressed person, without any therapy, is like giving amphetamines to a tired person: yes, they may temporarily cure your "tiredness", but what you really need is to go to sleep.

So while I don't think OP should take detailed advice from random strangers, he should be aware of his options. Talk to a therapist first to see if they can uncover what some of the root cause issues are. Be open to medication - some mental issues really are largely organic in nature, but a good doctor and therapist will know they are just one tool to improve your mental health.
In the beginning of SSRI consumption, it causes initial 5HT2C upregulation and activation, which can directly cause feelings of anxiety, dread, hopelessness, and restlessness/akathisia[1]. Over time, however, the body down regulates 5HT2C in response to its activation, and those symptoms tend to dissipate.

In a way, yes, there can be feelings induced that can provide the motivation and energy to go through with suicidal thoughts, but those unpleasant emotions aren't exactly triggered by an inherent will to die. Those who experience akathisia sometimes feel like the only way to rid themselves of the feeling is to end their lives.

I point this out because it might seem, or feel to those experiencing it themselves, that those suicidal thoughts are organic and what the person really wants, but they tend to be exacerbated directly by medication and can get better with time. I also point it out because there are ways to sidestep 5HT2C activation with different medications or combinations, it doesn't necessarily have to be inevitable.

[1] https://en.wikipedia.org/wiki/Akathisia
I think a web browser is particularly suited to a large number of developers, like an OS, since it has so many components from different threads of software development (networking, parsing, JS + WASM Engine, layout & graphics, text shaping, font rendering, GUI). Further, the top level components are easy to decompose again (layout engine, composite engine, SVG renderer, CSS effect renderer - for example).

A modular browser would be nice - where custom components can be swapped in for certain functionality (layout, networking, JS engine, CSS engine, renderers for various MIME types).
Correct, though the case insensitivity hasn't ever cause me issues in Nim. Searching is easy or at most takes a simple regex. It's actually saved me from a few dumb overshadowing issues (as in "you can't redefine 'is_active' see 'isActive' here").