skysight-inc/HackerNews huggingface dataset:
There appears to be a general MO of drug companies.

Make the bulk of your profits in the US market, and subsistence elsewhere.

I am not saying there are not other associated "Medical Industry" problems (lack of pricing transparency, 3rd party billing, EMTALA, EMR/NonClinical time for Doctors, Certificates of Need, disincentives for Cash payment) but this is a big one.

Also, many countries appear to have weaponized their IP in order to force drug company massive discounts.

As much as US Taxpayer $ goes towards much of the industry I am now in favor of outright nationalization for the established bigPharma. Let cutting edge biotech / lab space stay private, and BigPharma go nationalized.

At least maybe then we'll not be paying the world's bills.
I don't think its a question of scale, I think like the author of the article that it is a question of architecture.

It could very well be, for whatever reason, that the only way to arrive at this architecture is 3 billion years and a chaotic process.
I don't disagree with you, but I'm not sure I worry about it.

The article is presented as a letter to a car thief, a preposterous proposition right up front. It is not presented as a repair guide or an "evaluate whether a 914 is worth buying" guide, so it's really only of interest for entertainment and nostalgia purposes.

There's literally zero chance I'll ever be in a conversation with someone and say aloud "Oh, Porsche owners call this Neverland," and have to worry about someone interrupting me with, "BS, I belong to a Porsche club and have never heard this nickname."
Yes slave is derived from the word slav as they were the victims of the brutal ottoman slave trade for hundreds of years. We should be nicer to our slavic bretheren.
I loved nb! Until I ran it from a top-level directory and it committed an update to every git repo within that top-level. :D. Definitely operator error, but I learned my lesson and am back to separating notes from todos.
Yes, clearly I2C, properly employed, adds far more to observability than it might, in principle, very rarely take away. And of course: a) Oxide is not the first to use the same components; b) Oxide is past the point of bring-up problems with a previously untried component; c) Oxide will have done all sorts of power cycling and confidence-building; so d) common-mode failures can likely be ruled out; and e) (I presume) any rare bus hang or error can itself be detected and reported.
> It always entertaining when Americans speaking about manual transmissions as something mysterious.

It is always entertaining to see European exceptionalism schooling up people in car forums. Please tell us about diesel engines too!
Another fun one is the multiple index problem:

http://pepijndevos.nl/2012/08/12/the-multiple-index-problem....
Got it. I'm familiar with persistent data structures but I was more curious as to the "Haskell approach" of doing the same problem (which, I assume, doesn't use persistent data structures per se).

Follow-up question: if you wanted to implement the interpreter (as in the author's article) in idiomatic Haskell, would using the State monad be one solution? (I assume that's what you meant by "compose functions that manipulate that state"). Then, if you translated that Haskell directly into Racket (something like: use the exact same functions, just delete the type annotations), what would be the run-time of the solution?

(Not a trick question, I really don't know the answers. I've "understood" how the State, Reader, Writer work in the sense of reading the code, checking the types, and confirming that they do what they claim, but didn't think about how a compiler would compile them before)
Please open source your project. It sounds like a lot of (designing, as well as coding) effort went into making it, and you don’t want to see all that work go to a waste.

Do not worry about it being buggy, or even it being bad (design, or code). Let others do that work for you :-)
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If you're interested and would like to find out more about the roles, send me a note at jacob.heric@bluerabbit.vet with HN in the subject line!
EU Parliament Passes Privacy-Busting Crypto Rules Despite Industry Criticism
This is true. If the study had shown an effect, it’d be big news because it would up-end what we know about chemistry.
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I'm a soon to be graduate in Computer Sciences and Financial Mathematics from Université de Montréal, with a solid experience in financial systems. I have also worked in DevOps and as a back end developer. I'm comfortable with Kubernetes, GCP (and AWS), Docker (and containerization in general) Python, JS, Node, PyTorch, and more.

I'm looking for an internship or full time work, and I'm very interested in exploring new tech stacks.

Résumé:https://drive.google.com/file/d/1d4-kimKTPF8bMhi_16JH_cjbOPg...

anasselimrani @ gmail . com
I think that having a formal spec would help since a lot of the minutiae that is done to format and the like can be in the form of snippets in (nearly all) text editors used today.

So just having the autocompletion for people editing in text does wonders.

As for standardization, applications don't have to target it as their on-disk format for it to be useful. Instead of bespoke JSON/XML schemas or proprietary formats, having a plain text export format is a big win. Specially if it's human readable and human writeable.
Location: Toronto, ON (Canadian PR, EU citizen)
Remote: I prefer onsite but happy to talk
Willing to relocate: No
Technologies: Python (pytorch/sklearn/pandas/numpy/django/...), Fortran, SQL, Linux, Git. Basic HTML/CSS/JS and cloud technologies. Used C/C++/C# in a more distant past.
Résumé/CV: https://www.motloch.net/Motloch.pdf
Email: motloch {at symbol} posteo.de

Currently a postdoc at the U. Toronto interested in data science positions. Physics PhD from U. Chicago from 2018. I have spent the majority of my postdoc by analyzing various astrophysical datasets. To add to my well developed analytical and research skills, for the past two years I have been preparing for the transition into industry by taking Coursera courses, reading up on the various data science topics and playing around with various real world datasets.

Looking for a full time position.
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Our tech stack includes React.js, React Native, Node, Graphql, Typescript, and GCP. Front-end, back-end, and full-stack engineers are all welcome to apply!

Full job description: https://angel.co/company/lovd-2/jobs/2088482-senior-software...

Feel free to email me directly at lauren@lovd.com
I did not mention Amethyst despite liking what it does because it is what I'd call "begrudgingly configurable." It will let you configure it, but it would rather you didn't.

The trade-off is that yabai is instead annoyingly configurable, and its set of sane defaults is just okay. The only way I've found to mitigate this is by browsing yabairc/skhdrc files on github. I steal whatever looks good, and I keep it if it works well for me.
oof, didn't know that
Contrasting that to California, I had an old well-maintained Volvo station wagon. California tightened the emissions standards on that model until it failed smog (at 110% of NOX limit), and made me upgrade the catalytic to an after market one. It then passed at 85% the NOX limit.

The state strongly encouraged me to send it to a Golden Shield mechanic. As part of the work, they "checked" the air intake filter and MAF sensor on the engine, which was, of course, filthy. It sits in a big plastic box on that car. Instead of reinstalling the filter, they jammed it in sideways and closed the box. I figured it out later, and spent about an hour picking bits of leaves out of the downstream air intake.

Of course, this cost 95% of the limit past which California gives you a free pass till the next smog inspection. (And almost 2x the market value of the car.)

I'm convinced the whole thing is a make-work program that's holding our air quality hostage. (And I'm strongly for tightening emissions standards!)
This is a useful model. It's not perfect obviously, but I and a lot of my gay friends do the same thing. I'm not going to put myself in danger just because you feel that I need to test the waters with self-proclaimed "patriots" and their associates.

Sometimes you'll be ok temporarily in those spaces until one of their friends/family shows up who's not and it becomes a problem. Generally, you don't have to wait that long.
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Job Posting: https://www.ycombinator.com/companies/loops/jobs/yUbFitU-ful...

Contact: adam[at]loops.so

Adam, CTO Loops
Always look at the amendments...

The amendment attached to this bill is probably a "poison pill amendment". The bill itself plays well PR-wise. But the amendment probably contains language politically damaging to the opposition party.
Gorgeous! My mom had one of these that I would play Crystal Caves on for hours. Any room left in the case for a battery pack?
If you select the timestamp of a comment (also when you reply to it) you can favorite it. This is much cleaner than leaving scattered "to find them later" comments around this site (in fact, I'm pretty sure it was added precisely to avoid those kinds of comments). You can also favorite submissions themselves. Favorites can be found in your profile.
I'm not responding defensively in support of the US, I'm only engaging in a genuine discussion of your criticisms.
Location: Buenos Aires, Argentina
Remote: Yes (preferred)
Willing to relocate: No
Technologies:
Proficient: Python, Django, HTML/CSS/JS, Git;
Familiar: Rust, Julia, Docker, Phaser3
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Résumé/CV: https://arielroffe.quest/CV.pdf
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PhD Philosophy researcher from Argentina, with a strong background in mathematical logic. Looking to transition from academia into a software dev role, in search of new challenges. Proficient in the Python/Django stack, but also open to roles outside web development.

Personal website: https://arielroffe.quest/ (was recently featured on the cover of HN)

GitHub: https://github.com/ariroffe/
Does the network for for anyone?

I wanted to test out my website in Netscape, but it wouldn't connect...
ZF8 seems to be used by Audi only for cars sold in America?

btw.
ZF means Zahnradfabrik Friedrichshafen. Which is owned by the Zeppelin Foundation. Which was founded to support the built of Zeppelin Luftschiffe and social purposes. Weird story. And the Zeppelin Foundation was for a long time owner of Cherry. The company behind most mechanical keyboard switches. They should've kept that, growing business area - mechanical switches ;)
> Insulin costs under $5 to make.

Alright, here's what I don't understand: Why isn't the market working here? Why doesn't someone sell insulin at cheaper price, steal the ~ whole market, and make a killing? Is there some sort of cartel gentlemen's agreement? Is it impossible to get licensed to sell insulin? Something else?

Gotta be something, right?!
While I agree with the general premise that the rest of the world subsidizes the US to a degree, I don't think IP is an example of that. Countries are perfectly capable of saying no to US IP laws, but they don't because the trade that comes with saying yes is well worth it to them.

Where the US gets subsidized is our currency. The dollar, for the last 50 years, has been such a stable and useful tool for trade, that demand for it allows the US to run and import/export deficit via its printing. Foreign labor is cheap in dollar denominated terms, which allows US citizens to trade their own labor for several times what it is worth.

I think this is a lesson every US citizen should pay attention to when they advocate radical change: a big part of your lifestyle is paid for by stability.
Entirely possible, but perhaps the same is true for you as well? And if the conclusion that said someone wants me to reach happens to be true? Does that make a difference?
The application denies access to intruders by successfully ceasing to function.
Bitcoin, just like traditional money, can exist as a non-blockchain ledger entry in bank's computer system. This is how most exchanges and custodial wallets work.

The difference is, you can also self-custody your Bitcoin. Obviously what's in your custody is just a private key; but for all intents and purposes that is self-custody. You are the sole person in control of those coins.

So Bitcoin gives you the choice of how you want to store it. Traditional money does not give you that choice. At a certain point there are physical and practical limits to how much cash you can self-custody (not to mention transport or transfer from one place or person to another).
I have used Markov chains for a few fun projects, like this Markov chain headline generator (https://locserendipity.com/Markov_Headlines.html), and a Markov generator based on a certain someone's Twitter feed (https://locserendipity.com/Markov_Trump.html), but this looks like a good resources for more serious applications.
Study highlights: device usage 1 - 20 minutes per WEEK. Study population born 1935-1950, less likely as users of tech. No actual exposure data. Can't take this seriously.
Amazon workers vote to join a union in New York
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The company was founded by software engineer who is leading our development team. We try to limit meetings to twice a week.

1) Senior Software Developer (Ruby on Rails)

- Back-end development of our web app, including downstream APIs (for ex: Twilio) using Ruby on Rails + Postgres/Redis/Solr
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https://gist.github.com/dmix/e872e8898d895b8166f7f8912a7df34...

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- Familiarity with Ruby and Capistrano is a big plus

https://gist.github.com/dmix/117c9668445b5295d3df77cd081ade7...

--

Contact: dan+hn@retreaver.com
Well done. Someone should share this with the current Stack Exchange designers, since they don't know what the hell they are doing.
It seems to me the threat model of Rust is a magnitude safer than that of Bitcoin under assumption that Bitcoin was to become a global store of wealth. Toxicity acts as a shield to protect against social attacks from the big players which may try to, in some way, capture control of the network or influence its direction. And there are very good incentives to try and do that. It's also why it's important for the protocol to ossify over time and become even more conservative. Rust, as well as the vast majority of open source communities, doesn't really need that these levels of toxicity to survive in the long run because the attack vectors aren't on the same level (although still very important to deflect attacks because there are other incentives in play). At least it seems to me to be this way, I'll gladly listen to a counter-argument.
> Why do these guys not just build a lisp OS on top of some UNIX-system, so that every call to the OS goes through that layer?

In Mezzano's case, presumably because they wanted to build an OS in Common Lisp, not on top of the C that a Unix system would be implemented in. Looking at their Patreon (https://www.patreon.com/froggey) and FAQ (https://mezzanos.herokuapp.com/static/everyone/faq1.html), part of the purpose of the OS is to re-explore the Lisp machines from the '80s.

I know that if I built an OS, my purpose would likely be either learning, or experimentation with some concept that would be difficult to implement in any of the standard existing systems. Building on top of an existing base would defeat the point of the exercise, IMO.
Affordable insulin is a no-brainer, slam-dunk, overwhelmingly YES piece of legislation. I cannot comprehend the mental gymnastics diabetic republicans must go through on a daily basis.
Yes, because in the 15-19th centuries, Europe was busy colonising the rest of the world. This led to an overlap in their histories - something the colonised usually are thoroughly educated about relative to the colonisers.
But, in our global zeitgeist, Western culture is quite well known, while other countries' are usually seen through outdated tropes.
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I agree, ideological diversity is important for the same reason genetic diversity is important: the results of protracted inbreeding are almost always catastrophic. The price of tolerating a lot of woo-woo and other nonsense buys us a society where we don't end up forcing people to recant heliocentric astronomy.
Really nice resume. Love how short and sweet it is. It definitely showcases your knowledge in cloud dev-ops/backend work. Would add some details about your frontend experience (especially with you listing react as one of your skills) unless you're avoiding that type of work (and if so, I would remove it from your skills and double down on your backend/cloud knowledge).
> I kinda agree with what you imply about the lack of logical coherence

I didn't imply anything, I explicitly stated that the term “wokism” as currently used, doesn't refer to either an actual ideology, cultural phenomenon, or even a set of ideas or groups of people more connected than that they are things the dominant faction of the political Right disagrees with at the moment of the use of the label.

> Don't you agree that there's a relationship between having pronouns in the bio, reading Ibram X. Kendi, being "intersectional", believing words are violence, and sporting purple hair?

No, I don't. Believing (certain uses of) words are violence seems to be common across the political spectrum, though which uses of which words varies, purple hair is pretty orthogonal to politics (as is the more common feature used in this context, blue hair), intersectional isn't something a person can be, and while the first two things do correlate with political positions the Right opposes they (and the political positions they each correlate strongly with) don't correlate very strongly with each other. (In fact, that's a perennial complaint of the group that represents the intersection of those two communities.)
This is the best summary I have read on the topic: https://tailscale.com/blog/how-nat-traversal-works/
From a video I saw recently I think some of the old lancias (group b stuff) were similar, the pattern was not shown but the driver referred to being careful with first so as not to launch the car in reverse.

So I’m guessing this was one of the standard gear patterns in the late 70s / early 80s euros, back when car affordances were often nebulous concepts.
When people say something is a "Bloomberg Killer" they're usually only referring to a proper subset of what the terminal offers:

Data -- It's not just exchange data but breaking news, earnings calls, shipping data, and any quantitative or qualitative information that might impact the price of a stock, bond, commodity, or currency. I'd imagine competitors could carve out domain-specific niches but it would be hard to match the breadth of information on the terminal.

Functions -- Any one function or type of analysis may be replicatable but matching the sheer breadth would be challenging. Again, I'd imagine a competitor could carve out a domain-specific niche.

Network -- Many financial professionals communicate and/or trade via the terminal. Network effects would make it hard to make inroads here, though a couple big institutions were (are?) trying with Symphony.

Familiarity -- New functions and features get added but breaking existing workflows is rare. A professional who invests their time in learning the interface shouldn't have to re-learn a new interface every few years just to do the same thing. (There are unfortunately more exceptions to the rule than there used to be, but the UI churn is less than most enterprise software.)
so basically, building in public?
The “customized wording” you’re seeing is “The LGPL”. It’s a different license from the GPL.

The history on the repo shows that the original license was GPL (June 2020), the author changed the license to LGPL (December 2022), and now they’re changing it to GPL again. https://github.com/ssh-mitm/ssh-mitm/commits/master/LICENSE
I really hoped he had put an LTE version of a Raspberry PI, to really let the Compaq live up to it's name.

This is awesome. I'm hopeful I can do a project like this someday with a Palm Vx!
Have not got the time to read this but. Let me guess. Another programmer in a functional programming language realizing that the state is all over the place and gets copied around but still is so importantly immutable.