skysight-inc/HackerNews huggingface dataset:
> Generally the solution if found to be a poor methylater is to take forms of vitamins that are already methylated, like methylfolate

Other possible treatments are L-Methionine or S-Adenosyl-Methionine (SAMe), as was recommended in my personal case of a deficiency in "methionine adenosyltransferase" (https://en.wikipedia.org/wiki/S-Adenosylmethionine_synthetas...). If you are on a concurrent SSRI (as many with this problem tend to need), the L-Methionine is temporarily used in lieu of the SAMe in order to help wean off the SSRI without the risk of Serotonin Syndrome that comes with SAMe + SSRI combination.

I'm not a doctor, just someone who has this as a patient.
They learned from people with 8, 9, 10, 11, 12 digit salaries.
Here's the same query on Google in 2009 vs now: https://twitter.com/ageitgey/status/1483410675548495874
And you go straight to fulfill OPs prophecy: "It seems like anti-union proponents will remind you of the bad times when unions had too much power,"

BTW, the way you characterise unions are interesting. Very different from how they work here in Northern Europe. I wonder if American unions really are as corrupt and screwed up as the Internet makes them sound.
A lot of games genres could make for good open worlds other than FPSes/action games/action RPG's. Would love to see a Mario open world (Bowser's Fury being a sort of proto example).
Most people have short term incentive initiatives at work. Unless there is a regulatory, financial, or compliance incentive, I don't see why a rational actor would plan 10-20 years ahead if their goal is to maximise value for their stakeholders & themselves.
And its easy... It not a "dark souls" or even minecraft hardness.. Its way easier.

A friend of mine installed minecraft after like 5 years or even more, he was playing it like crazy back then. He died like ten times before giving up...

I feel like new players have a hard time now in Minecraft because its full of "new mechanics" and monsters and traps and god knows what..
It also depends on many factors like your screen resolution. Most site I go to on my small laptop, 80% of the screen is covered with ads.
The GPU uses fairly modest resources when not in-use - it would be more expensive to get a custom board without a GPU and the returns for that sacrifice would be the definition of marginal. Regarding e-Ink and their refresh speed, while this is true historically and for the vast majority of screens (which is fine, given their uses) there are more and more screens that deliver well above 30Hz.

This design would allow for/have two removable batteries in the current configuration. Removing one wouldn't do anything other than lighten the device.
I'm actually a bit more shocked there's not more outrage coming from mid-level public health practitioners whose jobs will now be that much harder. Through incompetence, failure to admit and clarify mistakes, and deliberate steering of the narrative away from things they didn't want to talk about, this generation of leaders has destroyed the average person's confidence in public health agencies and we will likely feel the effects of this for generations to come.
Facebook is a particularly strange example. In most cases I am absolutely not surprised that companies will actively harm society to profit short-term, I mean, they have to increase profits for their shareholders who really and I really mean it; don't give a shit what the companies does.

Save for, say, big trusts that do represent the interest of their owners or sometimes states (like Norway) that might have a political agenda, the "caring" is way too diluted between way too many parties for any sort of social responsibility to appear.

But Facebook? As far as I know, yes it is a publicly shared company... but decision making is still pretty much on Zuckerberg's hand much more than almost any other tech company out there... so why? Is it that the leadership at Facebook think they're doing something good? Maybe Zuckerberg really believes in his `meta` dream so much that he's willing to sacrifice anything to get there? Peculiar to say the least.

In any case, I'll quote Milton Friedman: "there is one and only one social responsibility of business–to use it resources and engage in activities designed to increase its profits so long as it stays within the rules of the game, which is to say, engages in open and free competition without deception or fraud.”. But I will add a little bit more: if you have money, you have power, if you have power, you get to choose the rules of the game.
back when I was a teenager, I read a few bits that referred to it as a “VoPo”
Oh no, 5 weeks of paid time off, 35 hours work week, universal retirement fund, physically hard jobs getting to retire early. And once a month some trains don't come in, and they dare warn you a week in advance. France is truly unlivable, a socialist hellscape :(
Spacewar Is 60 Today
Very nice, now awk really is a proper demo platform.
Nobody cares about social responsibility, and you'll be hard-pressed to ever get anyone to genuinely care. Our "profession" has gone out of its way to establish new avenues in which copyright can be applied solely so we could "own" bits. Anyone releasing proprietary software is ignoring social responsibility.

Guess what? Nobody cares! Money is nice! It buys things! And Facebook gives its employees fascinating tasks and enjoyable work!

Nobody who works on software for a living, or is employed by a company largely based around software, has any right to judge any Facebook employees on the basis of "ignoring social responsibility," or not factoring in that people will feel the pain of their actions in an abstract future.

This profession systematically ruined a beautiful field and destroyed the potential it could have had to drastically help the human condition. We lost all right to talk about morality in 1969.

Who can honestly blame them? Who has the right to throw a stone, here?
Classic Doom with Ray Tracing
it's legit concern for base64, which can spell worse things. i made a base 50 that fixes this
Still have my Psion 5. The keyboard was so much better than so many keyboards today. Sadly it was to slow for Internet. Also no good way to connect. With IR to the cellphone, it was slow even just to send an email.
Would be great to replace the link with this one.
I am doing research on how to measure the energy consumption and thus carbon emission of software.

The toolchain will be open-source and the data free use. Currently it is only a prototype and there are many open research questions to be solved.

If any of you is interested in this topic or would like to connect please feel free to contact me.

Currently we are a team of two and I also have backed the research through my own company and can supply compensation for the open source work.
Would love to find like minded people in this domain.

https://github.com/green-coding-berlin/green-metrics-tool / https://www.green-coding.org
I tried to apply CRDTs many times, what I learned: CRDTs sound great in theory but for most use cases they cannot be applied to the buisness logic.
Most of the time you either need to read out other information in from different collections to resolve a conflict. In other cases you have to ask the user to resolve the conflict.
The cases where CRDTs work great are also the cases where you do not really care about conflicts and a last-write-wins is ok.

https://rxdb.info/downsides-of-offline-first.html
As someone who has been trying to convince hiring managers of this very thing (dual major in electrical and mechanical engineering) it's harder than it sounds to find a job that crosses the bridges. Just my two cents.
This article is very hard to read without cringing painfully hard. I do appreciate the charts, but the article rapidly descends into incredibly poorly-considered ramblings:

"European nations have been so obsessed with their own glorious past, avoiding war, and pushing economic growth, that most of them—especially the big ones—haven’t realized they are small nations yet. Once they realize it, they will be ready to shed their baggage: their national identities. Only when they build a European identity stronger than the regional ones will Europe be ready to unite. Will they become a true nation."

Why has Tomas uncritically assumed that national identity is "baggage" and that the only path is towards greater centralisation of power? Just so "the EU" can get the highest numbers in the "GDP" game? So that a centralised military can threaten other nations to gain more economic advantage? I can't think of many Europeans I know who would prefer to emulate US or China rather than maintain their current identity.

I think Tomas Pueyo has written some superb articles, but this is absolutely not one of them. It sounds like an overzealous politics undergrad drunkenly boring someone at a college party.
It generates functions. Though not with a “$@“ at the end, so passing additional arguments at this moment is not supported. I also run a syntax check before the function is added to the file.
Thanks man :) I don’t really cache the issues, they are just stored in memory. So if you close the tool, it will refetch them next time.
> Could you point me to a reference about the 14 relational operators and what this has to do with partial orders? I've never seen anything about this in theoretical mathematics.

In a partial order:

There are four relations that a left side item and a right side item can have. Equal, less, greater, unordered with.

A relational operator could look for any combination of those relations, so 2^4=16 operators, except 'any' and 'none' don't make sense so there's 14.

==, <, >, <=, >=, <> make six.

Six more are "== or unordered with", "< or unordered with", etc. Negating one of the first six operators gives you one of these.

The last two are "unordered with" and its opposite "equal to or less than or greater than".
Even before reading this I definitely got SoC vibes - riding through a vast and empty world + that tense combo of loneliness and beauty
Money buys financial independence and time.
OP here: "Spacewar! 2B", the version shown at the MIT Open House in May 1962 is labeled "2 Apr 62" — exactly 60 years ago, today. Moreover, a first description of the game was published in the very first issue of "Decuscope – Information for Digital Equipment Computer Users" (Vol. 1 No. 1, April 1962, pp 2 and 4).

To celebrate the event, the emulation was slightly overhauled.
You're right. Fixed, thanks!
In Northern Europe we put optional and union in the same sentence, and it works well. But there is social pressure to join, and many places everyone, or almost everyone is union members. And maybe more importantly, the unions are usually big enough that they have power even if not everyone are members.
I think there's a difference here, one that I didn't see immediately either.

No one in this subthread is talking about the millions of Republican voters out there. The people being talked about is the much smaller group of people who set Republican policy. And we don't need to read their minds; we can look at their policy platform and directly witness what they support.
With the vim plugin? If not, how did you adapt?
Yeah I use gh pr open —web
I've never heard of a 30 hz e-ink screen. Do you have a link? Yeah most SOC's have gpus now, e.g. the one in the rpi compute module. Better to use modules to the extent possible, rather than custom stuff.

Today's computers bring woe to their users. A new one is only interesting if it solves some of those woes. Which particular woes is this proposed computer of yours supposed to solve? What do you plan to use your own for?

I'm frankly mostly happy with the 10+ yo Thinkpad X220 that I'm typing on right now, for what it's worth. A good replacement should first and foremost have solid Linux support that is preferably blob-free.
Facial reconstruction of skeleton found in Skyrim
You do have a point. Replaced Jupiter's day length with a good night's sleep. Thanks!
Sorry I have no idea about that. But a quick and dirty fix for your problem could be to split your pdf file into multiple files each with less than 200 pages.
NYUs online deep learning course does a good job explaining the first two paragraphs.
I'm a big fan of Rectangle Pro. I just got a new MacBook and it only felt like it was really "my machine" after installing karabiner + rectangle. Thanks for making it!
Jordan Peterson, israel, palestine, USA, israel
I believen OpenMW is considering this as a goal, but the modding/level editing tools aren't there yet (they're still focused on getting morrowind support better for now)
Words can only hurt you if you let them
Theater superstition is an entirely new area for me. I don't know why you would assume otherwise for a forum full of computer nerds.
From almost the start of the article:
“The Nobel Peace Center advertised the event precisely on social media, but ads on Facebook were removed, without further explanation, as "political advertising". The center has received ads for other events on Facebook without any problems.”

Summary: Facebook is removing Nobel Peace Center ads about anti-Facebook event.

Or am I missing something?
Check out the “Extra Styling” section.

Classes:

* .sticky

* .row

* .col

* .col-[1-12]

* .card

* .card .info

* .card .warn

It’s minimal, but not 100% classless, unless you stick to the basic styling, which isn’t as comprehensive.
TIME is now owned by Marc Benioff of Salesforce.com fame, so that creates all sort of interesting conflicts of interest, but the CEO class doesn’t generally turn on its own.
An equivalence relation can also be either total or partial, like an order relation. So the reflexivity may be true only for a subset of the complete set on which the equivalence relation is defined.

I have mentioned this also in another reply, but the following are the differences between total relations and partial relations.

On a set where total equivalence and order relations are defined, when 2 elements are compared, the result is 1 of 3 possible values: "equal", "less", "greater".

To the 3 values correspond 2^3 - 2 = 8 - 2 = 6 relational operators. In C notation: == != < >= > <=.

On a set where partial equivalence and order relations are defined, when 2 elements are compared, the result is 1 of 4 possible values: "equal", "less", "greater", "undefined" (a.k.a. "unordered").

To the 4 values correspond 2^4 - 2 = 16 - 2 = 14 relational operators.

In both cases, the 2 operators that do not exist, so they are subtracted from 8 and 16, correspond to the always true and always false operators.

For total order relational operators, "!= >= <=" are the negations of "== < >".

For partial order relational operators, that is no longer true, because e.g. the negation of "<" is no longer ">=", but "greater, equal or unordered".

So none of the 6 operators "== != < >= > <=" is the negation of another of these 6. Their 6 negations are distinct relational operators, which results in 6 + 6 = 12 relational operators.

The extra 2 operators until 14 operators are "is unordered" (i.e. isNaN for the case of numbers) and its negation.

I am sorry but I do not remember now references. However everything about partial relations are just trivial consequences of the fact that the 3 possible values of a comparison become 4 possible values.
Yeah I did my best to compress it but it's so noisy that there's very little compression that can be done without turning it into a blur. I can give you the original lossless PNG frames if you want them, but honestly I don't know that they'd be that useful.

Here's one lossless frame from near the end of the video, it's kinda nice because it gives you a little bit of context for the final Waldo without being overwhelming. https://i.imgur.com/wNZICnP.png

Here's also the full image as a 21.2 MiB PNG: https://ipfs.io/ipfs/QmUJaeon4KjE2RGVirXTG5xQuA6pCWV5T9GW2KS...

The full image contains the first 99969546 digits of pi, including the opening 3.
Haha thanks man, appreciate it :)
I know this is a space for entrepreneurs, bit it is a little bit annoying to constantly see folks jumping out of the woodwork with "you should try my product!!!!" whenever there is something semi relevant posted
I recently moved from a conservative state to a liberal one. The government at the former was far more controlling then my new home. I’ve never understood this argument. Conservatives are just as invested in intervening in our lives. See recent legislation limiting medical access, voting rights, environmental protections in the Southeastern US.

In my new home. I have better access to medical care, the outdoors are better funded, voting is simple and easy.

Both parties want control over the populace. The idea one party is advocating for more “liberty” is a reductive way of viewing politics
I am super into macro keys and I have been thinking about buying a foot pedal for ages. Aside from my 5 dedicated macro buttons, I have remapped the numpad buttons, the function buttons and several other buttons to macro functions. I also use a mmo mouse which has its own set off macro keys. It doesn't stop there as I am using HIDmacro to remap several keys own my laptop's keyboard. I also use AHK.

For the average macro lover getting a foot pedal has very little utility to offer but it does sound cool. The productivity bump of footbpedal is non-existent. But like homeopathy if you feel good about using something you will find it to be effective somehow.
Indeed. Editorializing the title to represent that as an "anti-Facebook-ad" is ragebait, especially as it isn't referred to as such in TFA.

EDIT response: You are free to call it an "anti-Facebook" ad in comments (though I'd disagree; the event was not against FB per se). Either way the title is misrepresenting the article as the ad-removal is just mentioned briefly and then talks about other things. I think you can still edit it to correct the mistake.
HN guidelines:

> please use the original title, unless it is misleading or linkbait; don't editorialize.
> Nobody cares about social responsibility

I'm not gonna argue whether people must care about it or not. But saying that nobody does is simply not true and sounds like an attempt to excuse yourself. I know quite a lot of people who made career decisions which did not maximise their profit in favour of not doing things your conscience will torment you about.
Fully-remote startup communication across ~8 time zones
That's exactly where my mind went when I read this post too.

The link for anyone interested: https://github.com/DisplayLink/evdi

It's unfortunate it wasn't accepted in-tree because while it was initially developed for a specific commercial product, I do think it has the potential to be generically useful.

The ability to conjure up a display "in software" & then just have the rest of the system automatically treat it as any other physical display is pretty powerful.

There's a couple of projects on my long "projects to do" that would make use of it...
I needed a way to document my shell scripts (or code snippets) and to quickly replace “parameters”. For example, if you want to download a YT video as mp3, you have to remember this command “youtube-dl --extract-audio --audio-format mp3 <video URL>” . You can use the autocomplete & history in the terminal but you still have to remember parts of the command and replace the old URL with the new one. You can also save it in a text file, and replace <video URL> … too many select/replace/copy/paste ops…

A few months ago I made a good enough solution for my problem https://github.com/alexadam/reactive-doc - it saves ~ 10 minutes/day when I have to run complex devops scripts. And I can quickly share the ‘docs’ because they are just plain html files / or markdown.

Now I just finished the next iteration - better ‘syntax’ for input widgets, runnable @shell commands and a web based terminal https://github.com/alexadam/shell-driver with custom filters and selection actions (useful for me)

Next steps: add more features to the web based terminal -> convert history to scripts, autocomplete with parameters, command palette & context aware menus, multiple terminals (with tabs or panels). I also want to add support for React components in the MD editor.
Having looked at e-ink in the market, I would strongly suggest an alternative display technology like RLCD or transflective LCD.

But I would absolutely pay for something ultra portable but with a good typing experience, without those silly dogmas of clam shell designs and 'make it as thin as possible' obsession.
SingleStore (formerly MemSQL) (https://singlestore.com) | Lisbon (Portugal), San Francisco (US), London (UK), Raleigh (NC), and Seattle (US) | Full Time | Remote

SingleStore is a database startup focused on high performance and hybrid workloads (HTAP). Our customers include half of the top 10 US banks, 2 of the top 3 US telcos, and 12% of the Fortune 100.

Our product is a distributed, relational database that handles both transactions and real-time analytics at scale. Querying is done through standard SQL drivers and syntax, leveraging a broad ecosystem of drivers and applications.

We have been building SingleStore since 2011, and building a database-as-a-service product involves a bunch of interesting technical challenges such as:
Compilers and code generation
Distributed computing and fault tolerance
UI and User Experience
Integrations with connectors and third-party tools (e.g., Business Intelligence tools like Tableau)
Infrastructure that scales to dozens of thousands of database clusters across GCP, Azure and AWS

We have several positions open:

* Site Reliability Engineer (US Remote, Portugal Remote)

* Senior Software Engineer, Frontend (Portugal Remote, US Remote)

* Senior Software Engineer, Backend (Portugal Remote, US Remote) — Go, Kubernetes, Systems Engineering

* Engineering Manager, Managed Service (US Remote)

* A lot more positions… (see below)

Careers page with individual links for each open position: https://www.singlestore.com/careers/jobs/

If you want to learn more about the engineering work we do, check out https://www.singlestore.com/blog/category/engineering/.

Feel free to email me directly via david at singlestore dot com.
So most federal conservatives. Who are career politicians. Want to get rid of career politicians? After doing nothing to get rid of career politicians their whole career?

This doesn’t track. No politician from either side wants to limit themselves out of a job.
It doesn't matter how many houses remain empty in the US as a whole. Presumably locations with high vacancy rates are places with low demand (ignoring, for the moment, places with large amounts of foreign real estate investors who parasitically decide to leave their properties empty).

Raising wages in places where housing is in high demand, but short supply, will just serve to increase home prices further. That doesn't mean we shouldn't raise wages, it just means the real problem housing-wise is the lack of supply.