skysight-inc/HackerNews huggingface dataset:
Man, I hate the way that anything about vaccine side effects gets flanderized into "ANTIVAXXERS!". However I hate the "educate yourself" movement more, so here I am. (I missed out the "can" though, that's on me)

First a WHO link.:

https://www.who.int/news-room/questions-and-answers/item/den...

>There is an increased risk of hospitalized and severe dengue in seronegative individuals starting about 30 months after the first dose.

TL;DR vaxx good if you've been infected before, but if you're dengue naive, it might raise the risk of severe side effects

Now, on the topic of an actual immunological phenomenon with a name out of /pol/'s fever dreams: An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014204/

TL;DR: Original antigenic sin describes a situation where the body's first exposure to an antigen shapes it's future response. This ends tragically in the case of dengue, where the response trained on a serotype is unfortunately overfit. Upon exposure to a different dengue serotype, the immune system defaults the response fit to the original infection, resulting in a response dominated by an inferior antibody. The outcomes are thus worse.

From what I'm seeing in more recent publications this model of dengue infection still seems to be the general consensus.

As to why I dug into this area in the first place, I live somewhere where dengue was quite the bugbear, and the "second time kills you" story was mentioned quite a bit. Turns out it's a pretty interesting area, since it clashes with the layman concept of immunity. I'm no expert in this domain though, so if I've missed out some progression on the science here, I'd really like to know.

Edit:

As others have also pointed out, there's also the case where the antibodies even enhance the infection process.
Our credit onion mobile deposit is obviously checked by a human and they’ve actually bounced a check back as needing both signatures.
Pi Day Challenge: Can You Solve These NASA Math Problems?
They're comparable, but not equivalent.
The answer is surely what all of those auto-playing video ads are using. Anybody know?
"Hawking hawking. Stephen Hawking peddling aggressively."

That's rather rude considering the man was wheelchair bound, don't you think?
I feel bad for China. China has done everything in its power to stop COVID only the rest of the world to drop the ball. China has been blamed for origin of COVID even though WHO investigations found that COVID didn't originate in China. It's like China is in no-win situation, despite doing the right thing, because of propaganda spread by racist right wing politicians.
The heuristic can be reworded as adult parents are more knowledgeable and capable than children.

Put the average child in the position of the average parent and you will see the difference.

Think of how abusive the average parent is, then imagine them trying to parent with 10-20 years less development.
It's unlikely a single devops person or team can scale cheaply. The big CDNs have HUGE economies of scale (read: peering agreements) that make them much, much cheaper than trying to run your own edge network.

Hell, even if put your video on an established peer to peer network (similar to bittorrent streaming), the support nightmares would probably cost more than just putting it on an already established CDN.

There is really no reason to self-host videos these days. They are write-once (or very rarely), invalidated very rarely, and can be trivially cached everywhere, sort of a best-case scenario for big CDNs. Even if you didn't have to touch a single line of code, trying to reestablish just the business deals yourself across many countries and data interconnects would be ridiculously expensive.
So my little project was essentially a research survey on neural program synthesis - do you have any good sources on building program synthesis projects? I noted a lot of the literature talks about outcomes but rarely how I can go about building something small that takes some Input, Output tuples and returns some code.

Ended up dropping the MSc because of Covid and moving to the Bay Area but I'd love to eventually do a research-focused masters in the future. Which may be difficult, because I don't have a Bachelors to begin with and took a lot of effort to get onto a Masters in the first place lol!
"Although heavy metals are naturally occurring elements that are found throughout the earth’s crust, most environmental contamination and human exposure result from anthropogenic activities such as mining and smelting operations, industrial production and use, and domestic and agricultural use of metals and metal-containing compounds"

why? because previous to life as we know it today, the Earth's geologic evolution included phases that were literally toxic heavy metals-filled oceans, air and land surface. It was only after millennia of "encasement" that basic modern life forms could start to evolve. Modern humans have famously reversed that encasement process, first and foremost with fossil fuel activity.

Ever-more powerful sources of energy are readily found in ever-more powerfully toxic compounds occurring within that encasement, with enriched Uranium as a crown-royalty member of that club. Why do few care? because few have experienced real poisoning, or prolonged poisoning through the reproduction cycle that they know of.
Every time I hear this I try a different credit union around me. Sometimes they have arcane rules like "oh you don't actually have dollars in this account. You have 500 shares. At this time you may sell shares back to the credit union at a rate of $1/share". Or recently a credit union in my area emailed me my password after I signed up, and then they kept sending me it in the mail as a reminder that I hadn't activated my account yet. There's a credit union at my local health foods store run by a professor who self-hosts their website out of there and customer service is just his office hours, so I think that'll be fun to try next.
> that for some very brief window in time we actually had a media with integrity and ethics, even if completely serendipitously

I would like to request you to entertain the possibility that the media became so powerful and influencial for a brief period that they convinced everyone of that idea... the information revolution just helped break the facade by democratising access to information... because of which their model of story-telling which was based on large uninformed masses (or masses homogenously disinformed with biased story-telling) no longer worked.
Why would a contractor require special care? On the contrary. They supply you the work, you pay for their services, like you would a software company. The benefits they choose for themselves and factor those in in the rate they ask you. There are differences of course, an employee may be more loyal, but that's a different discussion.
its really amazing for me to see the amount of kurzsichtigkeit
"China's biggest problem is.... food availability due to lower exports of wheat from russia and ukraine could cause an issue too."

The same logical structured can be applied to not China:

"X country's biggest problem is ... food availability due to lower exports of wheat from russia and ukraine could cause an issue too."
> The heuristic can be reworded as adult parents are more knowledgeable and capable than children.

I think that's true in general, but when it comes to making decisions about the child I think that has to be weighted against another heuristic that's often but not always true: that people know what's best for themselves better than other people do. I think people often wrongly neglect that principle when it comes to children assuming that they don't know what they're talking about without taking the time to listen and understand their point.
>Becoming multi planetary isn’t some economic frontier - it isn’t a new world to colonize - it’s a required backup for the survival of life itself.

That doesn't make it feasible - as said survical is not by any means signed in any contract with the universe, and has very slim chances (and even in the wildest scenario, it ends with the heat death of the universe anyway).

Being "necessary for survival" just makes it stronger as a wishful dream.

>Thank god humanity takes thousands of different courses simultaneously. I hope one of those courses doesn’t go extinct.

Well, if huge resources are spend to send a few moguls, select personel, and other people in some shitty (compared to Earth) Mars colonies, while still continuing profitable (and destructive) business as usual on Earth, to the ultimate demise of billions and the half-arsed space-colony survival of said few, I wouldn't call it a win.

Neither if dreams of "we'll just make it to space if needed" and other pipe dreams help downplay pressing actions needed on Earth.
We don't really use that term (making someone redundant) in the U.S. I've heard it on British shows so I assume that's where you are. It means laying someone off, right? Meaning a workforce reduction?
The first 2 papers indicated by you refer indeed to the same thing as the article that started this thread, but they explain the possible method.

The principle is very similar with the sources of deep ultraviolet light used for photolithography. The laser pulses are used to produce hot plasma and to accelerate the electrons from plasma, which hit then a target, like in the traditional X-ray tubes. The interaction of the accelerated electrons with the target produces gamma rays. Finally, the gamma rays can be used to transmute the nuclear waste.

There are 2 problems with this approach. As everybody knows, improving the deep UV sources to have an intensity great enough to be usable in the production of integrated circuits took several decades and many billions of dollars.

The gamma ray sources that would be needed for waste treatment are significantly more complex and the output intensity must be much higher, so it is impossible to guess how much time and money would be needed, but certainly much more than for photolithography.

The second much more serious problem is that already mentioned in another post. If these gamma-ray sources would have a global efficiency of 1%, starting from the electrical input power, passing through pump diodes for lasers, then solid-state lasers for pulse generation, then heating plasma, accelerating electrons, radiation from the electron target and finally absorption in the nuclear waste, that would be an amazing achievement.

Actually a global efficiency of less than 1 per ten thousand would be more likely today.

The energy required to transmute all the waste from a nuclear reactor might be of 10% or more of the output energy of the reactor. Multiplied with a factor between 100 and 10000, the result is that a nuclear reactor would not be a net producer of energy, but a huge consumer of energy, making it useless.

A little more realistic would be to not treat all the nuclear waste, but only 1 or a few especially dangerous isotopes, e.g. only the radioactive iodine.

While this would reduce a lot the energy required for transmutation, a lot of additional energy would be needed for the separation of the desired isotopes from the radioactive waste.

Maybe transmuting only the iodine could be done in a distant future with a little less energy than the nuclear reactor produces.

However that would not solve the problem with the storage of the nuclear waste. Consuming a huge amount of energy with the elimination of the iodine would only lessen the danger of what would happen if the storage of the waste would be compromised and the waste would be dispersed into the environment (because the vertebrates extract the iodine from the environment and concentrate it into the thyroid, so radioactive iodine is dangerous even at smaller concentrations than the rest of the waste).
I know this is going to be a violation of the rules, but this is truly one of the most divorced-from-reality, stunningly dumb things I've ever read.
probably steer clear of the student who claims they failed because the teacher didn't like them
> That if someone really wants to understand where we are with all those Libya, Syria, Iraq, ... Ukraine.

I appreciate Mearsheimer's perspective, but for a self professed "realist", I find it strange that he talks a lot about "ideology" and very little about "oil".

At the end of the day all of those conflicts are conflicts over the control of fossil fuels. I have a hard time taking any analysis seriously that doesn't focus on this primary issue.
Honestly I’m surprised they admitted this. Historically companies and organizations would always blame whatever the current hacking buzzword is. I recall APT being an especially annoying example of this, until that buzzword disappeared and then suddenly everyone’s hackers stopped being APT.
How is what you are describing different than what Uber is doing?

Personally, under the circumstances when I take Uber, I don’t care about how much they charge and I tip the maximum amount allowed by our guidelines - 20%.

90% of the time when I take Uber, it’s for business travel and I’m getting reimbursed (consulting). The other 10% of the time I’m on vacation where I expect to spend stupidly or going into town from the burbs for “date night” and we don’t want to worry about parking or DUIs.

I live in a very car dependent metro area so I don’t have a clear picture of when most people use Uber for day to day use.

Well, I guess there was the couple of years we were spending $350/month on Uber for our son to get back and forth to work and go friends because it was cheaper than car+insurance.
Trace-based compilation in execution environments without interpreters
Isn't Fox New's official slogan "Fair and Balanced"?
> "Zero Trust" is an IT security model that assumes threats are present both inside and outside a network.

Particularly in the management suite.

Or, if you're in the management suite, all the people who work for you.

Better hire some consultants to avoid that problem.
I fully expect to make many mistakes as a parent, and there's a lot of things I could have done better.

As a child though, many decisions my parents made were with the view of demonizing outside groups and "protecting" their kids from any contrarian viewpoints. Catching up socially took years, and there are some extreme harms that I still deal with to this day. My goal is to make sure my kids have a well-rounded social life, a consideration for others, and an understanding of a gamut of ideas.
Having an understanding of mathematical foundations and proofs can be very beneficial to software developers; but I agree there are much better books than the ones suggested here. "Elements" is an historically important book (arguably the most important in math), but like you said is fairly outdated. Real Analysis is critical for higher level maths and theoretical computer science and does have some value even in software development. But with books like Spivak's Calculus you spend more time memorizing definitions and theorems than abstract thinking or problem solving.

Some better math books that I would recommend off the top-of-my-head:

* "How to Solve it" by George Polya - A great book on breaking down complex problems.

* "Mathematical Logic" by Stephen Kleene - A much more contemporary math book on building axiomatic theories from scratch.

* "Godel, Escher, Bach" by Douglas Hofstadter - Also about mathematical foundations but for a much broader audience.
I use Sketch to export SVGs, and animate them with anime.js. Here's an example of some illustrations where I did this [1]. It's not without issues though; using external (i.e., not inlined) SVGs is surprisingly tricky, and you quickly run into edge cases with groups and transforms---some notes here [2].

I like this approach because it decouples drawing and animating, and with SVG it is resolution and bandwidth-friendly. I was already used to making figures for research papers with Sketch, so I just suck with that, and added anime.js on top. However, for more complex motion like you might be hinting with your post, I could imagine a GUI tool with a proper timeline and tweening to be more ergonomic.

[1] https://maxwellforbes.com/posts/every-phd-is-different/
[2] https://maxwellforbes.com/garage/animating-svgs-from-sketch-...
I have:

- Your order of X (confirmation)

- Your order of X has been dispatched

- Arriving today: X

- Delivered: Order number N

Only the last does not contain the product name X.
Sure. Does every sentence in a discussion of X really require a disclaimer that the thing mentioned is not necessarily unique to X and can also be the case for not-X?
Careful now, you might not get paid if you use the w-word.
How to Benchmark Performance of Citus and Postgres with HammerDB on Azure
what kinds of services do you get from a bank/CU that cost money? I've been using schwab for a few years, and the only thing I've ever had to pay them for was the privilege of throwing away my money on a couple stock options. I've only ever had to contact their support for help with problems caused by a different financial institution, and I was speaking with a human within one or two minutes.
Ah... So they're differentiating MOOP levels they'll honor based on the provider in question.

I'm guessing they probably have some funneling arrangement that recoups the extra spend they'd incur from the potentially more frequent MOOP attainment in network.

Cute, but it really kinda sidesteps the concept of "Max out of pocket". I sense an MBA at work.
> 20 years of experience?

Staff, Principal, Fellow, or Manager.

Seniors also exist in college and high school.
Based on what ranking ?

Calories/per resident? There's many ways in which that is flawed.
Spinning a Lego Wheel Fast by Hand [video]
Oh god, University catering was the worst. They would happily charge fine dining prices for the most basic of meals, and would take forever to get back to you. I couldn't tell if we were getting the Fuck-Off rate or this was seriously what they charged everyone.
More age, and requisite life-experience, changes you as a parent. In some ways it's better, in some ways it's worse. I've been a better parent and a worse parent for my younger children - IMO 30-32 is/was the right age to get balance in these things.

I expect that differs by cultural setting, nationality, etc..

Couple of examples: I'm less hot-headed as I age; I'm less physically able (much more than I expected).
> get treated by the wrong doctor at the right hospital!

In California, this shouldn't happen. If you go to an in-network hospital, all care providers you see are required to bill you at the in-network rate.
> scare off those who are underqualified.

Worse, those who are well-qualified.
Climate Opinion Factsheets
The ad networks probably host their own videos. It's different when the videos can subsidize themselves through ad clicks.

Here's one of Google's: https://support.google.com/displayvideo/answer/6086451?hl=en
Weird to me that you consider casarecce exotic, whereas I had to google gemelli, because I don't think I've heard that name before.

I've also been exposed to a lot of training data since I spent 80% of my life in Italy.
seems the author should be aware of the Big Ball Of Mud http://laputan.org/mud/
As a student for many years, I completely agree I would not prepare as well without some stakes in the homework. However, using those super precise instructions can be harmful to students. It's very difficult for me as someone with ADHD to follow these instructions and not miss something.
There's a huge difference between exactly zero and close to it. Space isn't even that close compared to what's been done in a lab, and even in lab experiments the temperatures involved don't correspond to such effects happening.
Yes!

Science/engineering influencers are becoming more popular and doing a great job getting themselves funding and also generating very impressive content.

Look into -

https://www.veritasium.com/ - crazy science education and practical experiments to “prove new science”. Check out the series of videos on a sail powered car that moves faster than the wind that pushes it!!! It sounds impossible, and then Derek shows that it’s possible! Including all the debates with other scientists about it. Also check out the “how energy flows” and all the reaction videos - this topic hasn’t yet been explored further tho so be prepared to wait (if this type of conversation isn’t science I don’t know what is).

Mark Rober’s creative engineering classes, science based philanthropy with TeamSeas are meeting his goal of being effectively inspiring. This dude is going to generate a similar magnitude of new scientists and engineers as The Beatles have and keep generating new musicians.

https://youtube.com/c/K%C3%A1rolyZsolnai - People always wonder why I’m optimistic about the future. Karoly and his channel are a small but important part of why! Watching the pace of innovation here is the only way to truly understand the catch phrase “What a time to be alive!”. He curates scientific papers and gets them visibility better than the legacy science publications. This channel is the “new Nature magazine” and it’s funded by relevant/educational ads.

https://en.wikipedia.org/wiki/Hamilton_Morris - Hamilton’s work documenting the effects of narcotics and also the scientific pathways behind them is inspiring. His team and him haven't so much created videos or video essays as they have created the first audio-visual encyclopedia.

I’m sure there are many more I’m forgetting or haven’t yet heard of. You can also look into the Stanford/Harvard professors, the research doctors, the dermatologists, etc that are getting into YouTube/podcasts because it’s a better medium to have scientific information disseminated and hopefully draw more donations for their research.

Not all science influencers are doing “real science” yet. Some of them are “science news/educators” others “science documentarians” but many of them are already directly contributing to “real innovative science”. Pushing the boundaries of human knowledge and getting ”paid” to show it off!!!

Yes it takes a bit of curation to find the content creators that are also doing “real science” but for me it’s a no-brainer: in 100 years, because of the monetary incentives, more innovation will come from donation/ad based “science content creators” (on YouTube/podcasts/similar) than from legacy academic institutions.
The island is only 1.5 acres though. The size is too small to build any significant infrastructure. The island could maybe fit 100 people on it comfortably. I cannot find any reason that someone would want to visit this place for longer than a few hours.
Ntfy.sh – Send push notifications to your phone via PUT/POST
Congrats to the team. It's proven itself beyond useful time and time again.
Why would C++ need to reimplement libraries and other features when it already has access to the ones in C? If it was supposed to be an entirely separate language then they probably would have called it D (pretty sure C++ was a thing before the actual D language).
> Thinking of this as a ten or fifty thousand year problem expresses a tremendous pessimism in the human ability to innovate.

It’s quite fatalistic. The arguments are usually about protecting some future Stone Age human society from it. Seems like the assumption is civilization will crumble and human intelligence will decline so much that they wouldn’t be able to figure out or notice that some ancient waste they dug up is killing them.
If I'm working on a computer in a state, and the location of the employer is irrelevant, it would be hard for me to argue that I'm not performing services in that state--even if my full-time residence is elsewhere. Where else would I be performing them? But IANAL.
I feel ya. As a childless person of the same age, I have several of those things you mentioned. I count them as blessings but also see that there has been a big, big trade made for them. I see that my siblings have made different choices with different blessings. I suppose this is just life.