skysight-inc/HackerNews huggingface dataset:
I have also worked with bioreactors. Sounds like you have made some great progress. Just a couple thoughts:

1) there are plenty of other niches for microbe production that could possibly use the same technology. I am not suggesting you switch now, but something to keep in mind for the future. In my opinion, the current standard processes for working with bioreactors are slow and manual. I think there is a lot of room for efficiency improvements but it is rarely worth it for individual companies to make those investments.

2) Is all of the growth happening in a single bioreactor or do you have multiple sized bioreactors for different stages? I don't have a scientific background and I'm trying to understand the standard practices better.

edit: fixed typos.
Sounds like they didnt try hard enough. Just feed the AI wrong information in the first place and it wont have a choice but generate false info. If they are trying to get the machine to outright 'lie' then they are going to need to build a new program. Most machine learning is aimed at fidelity in the first place.
It's still a compilation target that needs to be managed by a build system. It doesn't address the complexity of the ecosystem, and just adds to it.
Gasoline costs a lot more than that in Europe and still everyone has a car. I think the current price is still a lot less than the market would pay.

I'm pretty sure people are going to switch to EVs rather than give up driving.
Lilypond also has a guile API, and if you are not interested in the actual notation generation or at least how it looks, it can make some pretty weird and cool midi files. You can turn it into a kind of makeshift lisp Supercollider pattern generator.
Yes definitely! A large impact can kick enough debris into the atmosphere to cool the earth. And people have floated the possibility of injecting basically a bunch of “debris” to combat global warming.

The problem is that the system is chaotic and injecting and then maintaining the exactly correct level of debris that cools us off a bit without triggering a global crop failure or runaway ice age is effectively impossible, not to mention the air quality issues intrinsic to basically all versions of this scenario.
> Another thing that I think would be cool is a tab filter. Press a hotkey, get a list of all tabs. Then press "hacker" and it highlights all tabs with hacker(news), and ⌘-w to close them. Or you could move all tabs with "office" to a new window. Or maybe you find a clever UI to select and close all old, not recently used tabs. This would be great to clean up all the old tabs that accumulate.

This sounds like a great idea, please suggest it to https://orionfeedback.org
Watch the video, especially the part covering the biochemistry. Fructose interferes with satiety signaling (leptin, ghrelin), which forces eating beyond caloric needs.

An unprocessed strawberry is healthy because the fiber limits the rate at which fructose leaks out of the chunks in your gut. Blend or freeze that same strawberry and it becomes junk candy.
Congrats on the launch!
How does that compare to using Stripe for charging customers?
The main downside of Wegovy/semaglutide is that it is incredibly pricey ($800-$1100 USD per month), and most US health insurance providers will not cover it as a front line treatment, and many won't approve it as a second line treatment without a good deal of aggressive lobbying by the prescriber. More than one physician has told me that it's often easier to get bariatric surgery approved than it is to get Wegovy approved!

This insurance issue isn't particularly unique among weight loss treatments with solid evidence-based proof of efficacy - US insurers rarely cover other typical frontline obesity treatments like phentermine + metformin, or bupropion + low dose naltrexone. These latter options are available very inexpensively as generics; semaglutide is only available in pricey branded formulations.
Work less
I don’t think it means anything, since the JS parser will just ignore the type annotations.
Do you really think that child slavery for sourcing cobalt is "obvious" to most iPhone users? I doubt that.

https://www.youtube.com/watch?v=JcJ8me22NVs&list=PLnUeRIXMDq...
I will also point out that even if they are only observing ciphertext, they can still glean a lot:

http://web.cs.wpi.edu/~claypool/papers/yt-crawler/final.pdf
"who can easily eat 4000 calories of real food in a single meal"

"4000 calories" ? With "real food" ? In one meal -- how ? I eat 3 full meals and a weight gain smoothie and barely pass 2700 calories for the day. Is there something you would recommend adding to my diet so I can increase my calories a bit as I would like to gain some weight. But seriously unless your meal is 100% deep fried, I can't even picture a 4000 calorie meal.
My experience is Redshift works better on Linux whereas f.lux works better (or "is more elegantly integrated") on OSX
hidden at https://kable.stoplight.io/docs/kable/
Anyone interested in a visual exploration should checkout Geometrical Vectors by Gabriel Weinreich.

https://www.maa.org/press/maa-reviews/geometrical-vectors
Imagine a cooking pan that can't be heated.
Here you go: https://cloud.google.com/load-balancing/docs/ssl-certificate...
Configure EC2 the Cloud-Native Way Using AWS Parameter Store (2020)
See my other comment, but exercise can be a critical way that people both lose weight and maintain weight loss. Losing weight is relatively easy, but maintaining it is hard, and exercise can be critical to the latter.

You need to stop thinking about exercise as burning calories. Exercise can be critical in getting hormones, particularly leptin, back to a normal function. Exercise, particularly weightlifting, can help build muscle and prevent muscle loss from losing weight.

Eating less is not the secret. That's to reductionist.

The secret is altering your energy balance.

You can alter your energy balance from a combination of diet and exercise, and the way you handle both will further impact your energy balance. Your hormones will also play a critical role in your ability to maintain this as well.

Getting good sleep will also be critical for altering this energy balance and setting yourself up for weight loss. People who don't get 7-9 hours of sleep a night aren't going to be producing enough human growth hormone at night, and they won't be able to recover from exercise or build lean tissue.

I would never, ever recommend someone try to lose any significant amount of weight without weightlifting. It's a fool's errand.

Yes, you'll lose the weight by eating less, and in the process you may end up having half of that weight loss be muscle mass. Now your metabolic rate is in the gutter, and you have set yourself up perfectly for a rebound in weight.

If you want longterm weight loss, exercise and eat well. Try to get at least 10,000 steps a day and then aim for 4-6 days a week of strenuous exercise.
Compared with "No Framework".

Spring, ASP.net, Rails, Symfony, Django all follow very much the same patterns and architecture.
https://en.wikipedia.org/wiki/Solar_geoengineering
It's a tunnel into your internal network.

If nation states and/or cyber criminals do control most of tor, then you are opening your internal network to those groups.
Interesting stuff!

I've read that contamination is a huge issue, essentially, bacteria grows much better and faster at the substrate than mammalian cells. So, how do you avoid inadvertently cultivating smelly plaques instead of delicious meat?

Or is that not really an issue and I'm misinformed?

Best of luck. We really need it.
Substack launches an iOS app for reading newsletters
Yes!

I've lately been doing the form of intermittent fasting known as early time-restricted feeding. Basically, I start eating at breakfast and stop eating after lunch. I worked up to it over a few months, starting out just tracking when I already didn't eat and then slowly expanding the window.

A big surprise for me was that both my feelings of hunger and my relationship to those feelings changed. As that process happened, I used my "reverse engineering" brain to think about why hunger exists and what mechanisms genes would build to maximize success of nomadic omnivores for whom food is erratically but non-randomly available.

It's all just unverified hypothesizing, of course. But it was really helpful to me to think, "Ah, this feeling isn't really hunger in the sense of 'body needs food now', but more 'genes asking if food happens to be available to stock up'." After all, it's bad body design to have it wander around at all hours looking for food when it isn't available.

Having that mental distance from the sensations made it much easier to just ignore them for a while to see if they subside. And they have! To my surprise I experience less discomfort from hunger when eating 6 hours a day than I did eating whenever.
With inflation the way it is, I wouldn't doubt that prices close to $4 would be more where it stabilizes for a few years.
What are the steps to take a screenshot in Firefox?

I could not find it in the menus.

Thanks in advance!

EDIT: Ah context-menu (typically right-click) gets you to "Take Screenshot"
Or Twitter pronouns.
Argh! this was my mistake. I saw it and then forgot to tell Adam we needed to fix that before the launch. Sorry everyone! We'll get it fixed.

In the meantime, go to https://kable.stoplight.io/docs/kable/ (thanks mtmail!)
I'm with you and OP!

But as I mention in a comment elsewhere here, if I indulge in a breakfast I will get hunger pangs the next morning (or two). Which leads me onto "needing breakfast". If I push through and just do my coffee and cream, I can get back to not feeling hungry in the morning (no hunger pangs) and back to [my] "normal".

My philosophy is: I eat if/when I'm hungry, not because "someone" tells me I should. "Someone" might be society. Also "Breakfast is the most important meal of the day" is marketing BS started by Kelloggs(?I think?) to sell cereal.
Test Infrastructure Code with Terratest
> Its an example of a possible scenario so not really possible to be suspect.

This doesn't follow. I would expect any financial planner worth their salt to consider many different scenarios and make decisions based on which scenarios they think are likely... not based on which scenarios they think are possible.

The fact that it's possible for a decision to put you in a disadvantageous position does not mean that you made the wrong decision. It may just mean that you made a reasonable decision but failed to predict future market behavior.

The idea of using a 40-year high for inflation to do your long-term planning sounds like some pretty outrageous incompetence to me.
Muslims debate whether Bitcoin, dogecoin are allowed
The Resilience of the Internet in Ukraine
How could it not be? With type checking, you wouldn't be able to set a variable to a number when it's supposed to be an object.
Currently on the run from prison, he escaped about 6 months after this article

Here's the bit of PVC pipe he got 5 years for, I doubt it could work -

https://www.standard.co.uk/news/crime/man-jailed-for-five-ye...

It's sad every time you hear these stories about people living in underground car parks they have dry walled off or unused store rooms, for some reason society hammers them.

All the kids books I ever read, kids would run away from home and do this. It was seen as independence and exploring. Different times I guess. "My Side of the Mountain", "The Prince of Central Park", "From the Mixed-Up Files of Mrs. Basil E. Frankweiler" also the "Three Investigators" and their hidden hideout.
I know some of the supply side difficulties come down to electronics supply issues: We had a bunch of new, built cars just sitting in parking lots here (MI) that were complete except for some of their electronic components. It was bizarre to drive past dozens of unused shiny cars while people in town can't buy a car at a decent price.

I'd expect this aspect of the problem to stabilize in a few years at most, because if the components continue to be a problem, the car companies will either start making cars without them again (I wish but unlikely) or secure their own components' supply.
This isn’t entirely accurate. A hunter-gatherer society is not a civilization, and life-expectancy was low. We can also assume that due to injury, disease, and periodic starvation that the hunter-gatherer society didn’t have a surplus of adults, much less high-functioning ones. This is precisely why, over time, the hunter-gatherers of the Earth voluntarily chose to settle, to farm, and to organize into civilizations. The car or the horse is, generally speaking, not a tax on the individual as these allow higher rates of productivity than an individual would otherwise have. The smart phone, however, does not offer sizable gains in productivity, and conversely actually steals attention from the individual and therefore is a net tax on the individual.
Services like Netlify and Cloudflare already give you the option to minify your code when serving it. Removing the types as well is a pretty small step from there.
I've never encountered a situation where the lack of typing bit me in the ass. Not even once!

You absolutely have. At some point in your career, you've accidentally got the arguments to a function in the wrong order and had to debug what was happening. Or ended up with a `null` where you didn't expect it. Or used an invalid value for a string enumeration, made an inobvious typo in a field name of an options object, accidentally added brackets and called a function when you meant to pass a reference to it, failed to deal with the return type of a promise, or any number of other examples of mistakes that everybody makes all of the time.

These are all examples of common errors that can be caught by a type checker. It's totally valid to debate whether the cost of a type system is worth paying in the context of different environments, but if you're starting from the not-really-credible position of "I have never made a type error, ever", then it suggests that you're working with a set of faulty assumptions about what they offer.

(For my own part, as a Javascript user of some 20+ years now, picking up TypeScript has been the best boost to productivity and code quality I've had in my career. It's got to the point that I'd just point-blank refuse to work with a Javascript codebase now, because it's not worth it.)
I came to LaTeX the other way around: Lilypond for text? Sign me up!
“As a user, I only want to search for users whom I can pair with. All incompatible users should be excluded by default”.

Now go and build it.
Back to normal, as in, new oil just magically appeared? Regardless of international situations, and I feel strange needing to say this, we will run out of cheap oil. We will also run out long before the creation of a good petrol alternative for ICE vehicles. Alternatives are how the less than wealthy are going to make it thru. For example, I have arranged my life to not need a car. Wasnt easy and I need to spend my car money on a house but it is what it is.
> A better test suite can have exponential more value on maintainability than types.

A lot of ink has been spilled over this question. The conclusion is: no, tests do not and cannot replace types. Types, in themselves, provide a layer of tests that nobody, typically, would think of writing (what if a function is called with fewer arguments? what if it receives a different type of argument from what it was expecting?) and eliminate a whole class of superfluous tests that are checking for things that are better checked with types.

The self-documenting property of types is remarkable. Jsdocs do not hold a candle to a typed codebase.

Plus, refactoring. Even with tests I would be scared of large refactorings if I didn't have a type checker to also hold my hand. Of course, maybe I just don't know how to write code properly.
I am so used to articles with a meaningless header image that I totally skipped that the map they're talking about is right at the top of the page. My brain filtered it out. After going back and looking at it, I think the map is pretty cool and would be great if it were dynamic and navigable in a leaflet container or something of the sort.

But I agree I got tired of the prose about a third of the way in. I appreciate it, and can tell what they are getting at but I think regular hacker news readers are in a demographic that is already keenly aware of the interconnected nature of raw material extraction, supply chains, applied and theoretical sciences etc. I mean it's in our nature to process these thoughts because we're always looking for some missing connection, a forgotten or undiscovered niche, (edit to add, not to forget the human and environmental impacts of all of this as another user mentioned) etc etc.

I do think there's plenty of folk who might see this as eye opening, especially the average consumer for whom devices just materialise out of money. I imagine the philosophical angle would be more thought provoking for someone who hasn't sat down and thought about it a whole heap.

(second and final edit to add - on more thought I think if they made the map dynamic, and put the prose on little markers, that would be way more impactful to me at least as I think the spatial context would add a ton of value).
how about permanent damage over time from blue wavelengths possibly leading to macular degeneration?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734149/
Deploying Anycast DNS Using OpenBSD and BGP (2018)
Are All Your APIs Insecure?
Great question! So the basic medium composition itself is fairly simple, but the growth factors can be difficult to make. There are many places along the supply chain that are strained due to recent events. Because of this, procuring the food is somewhat difficult, but should become easier in the future. Many companies within cultivated meat (such as Heuros, Multus, Future Fields) are also working on animal-free growth factors by using precision fermentation. Precision fermentation is essentially beer brewing, but the yeast is genetically modified to produce a certain growth factor. As for being green, the industry is trending towards trying to find ways to utilize plants as much as possible across production phases. Eventually, besides the initial cells, most cultivated meat production could rely on common plants for the nutrients and growth factors for the cells. This could drastically decrease overall emissions, and even make the products carbon-negative.
> If anything from reading this article it feels like the running and marathon communities are hugely self-righteous and have a colossally overblown sense of self-importance

In general that is far from the truth. Running communities tend to be very helpful and welcoming groups in my experience. Yes, there are a few alpha-cock types out there and one or two online forums where they manage to dominate (mainly because they leave other groups where being an arse is actively unappreciated), but that sort of prick appears in all walks of life and running seems to have fewer than its fair share.

A lot of the noise that you do hear comes from outside the running groups sometimes. For instance most people making jokes belittling joggers compared to runners neither run nor jog, they just like taking the mick out of a recognisable target. It is like the people who hardly ever leave their couch unless they need to go get another beer going on about how Cantona should have taken a particular shot differently (yeah, my football knowledge is that up-to-date!).

> if you run a marathon, it should be about your own sense of achievement

I would agree there. Though if there are awards for best-in-class or otherwise they should go to the people who genuinely earn them.

> why care so much about what some other person has done?

People don't generally like a cheat in any area, If someone else missed out on a best-in-class or other result because of a cheater they are perfectly justified in being irritated and many will be irritating on their behalf.

The man didn't deserve bullying by an online mob, he needed mental help not harassment and the ban from other events should be sufficient counter action, but that doesn't mean we should dismiss cheating as a victimless action that we shouldn't care about because it doesn't directly affect us.
I’m sure people more educated than I can debate about this all day, I’m just saying that in the system we have as it exists today, the expectation is that the federal reserve will increase interest rates to combat inflation, and in turn this makes debt more expensive and increases the risk free yield rate

Edit: and just to be clear where I’m going with this, the market adjusts along these expectations. Why has the housing market been so insanely hot for a year now? In part because money is easy, and everyone believes inflation is coming/here, so getting a 30 year loan on 3% interest is a killer deal. Consequently home values are through the roof. But this counterbalances: you end up with a higher principle and lower interest for the same monthly home payment, and take on the risk that you will be underwater on your mortgage if asset values crash when rates rise.
I won't put too much stock in unglazed clay cooking ware.
I've got (too many) years of JS experience too, and I started a project in TS last November to see what the fuss is all about.

I have to say I'm a convert. Not so much because it's catching a ton of errors for me, more that it brings such a massive improvement in IDE autocomplete behaviour. TypeScript in VS Code starts to feel almost like C# in 'real' visual studio. (The errors it does catch in my code are usually potential null references which would probably have been fine, but I'm sure it's avoided a few bugs.)

The most interesting thing for me is that it allows me to feel safe doing things I would avoid in plain JS, like using literal union types (which would be magic numbers/strings without the typing).

I still write JS for small stuff, but when you're next starting a new project that'll go over a few thousand lines of code I definitely recommend giving it a try.
Study unveils new changes in the brain of patients with Alzheimer's disease
I've always wondered about the patina, or carbonized oil, on my cast iron and carbon steel pans. That stuff leeches over time too, and it's probably carcinogenic? Have there ever been any studies on the seasonings on those pans and any potential health effects?

That being said, I love my pans and probably wouldn't stop using them.
Those commanders will be prosecuted whether or not Russia "wins" the war. (I'm using scare quotes because there is no realistic scenario that could make this war a "win", so I guess what people mean by "win" as opposed to "loss" is in this case "permanently occupying Ukraine" at an insanely high cost.)
Exercise also changes a person's mindset with food. This is what a lot of the "just eat less" people don't get.

Exercise, particularly when you adapt a training mindset, shifts your relationship with food to one when you eat to fuel and recover from your training.

Powerlifting, strenuous cycling, etc. all require one to eat purposely to really seen gains.

Getting overweight people to start viewing their relationship with food as one to fuel their life's activities is a power mindset shift that can help lead to lasting weight loss.

Don't think of exercise as a way to burn calories. Think of food as a way to power your exercise.

Now get out there every day and get after it.
Could Uber and Lyft ask customers to classify themselves as

1. mask-wearers
2. non-mask-wearers
3. willing to wear a mask if driver prefers

and as people who
1. insist driver wears mask
2. insist driver does not wear mask
3. don't care if driver wears mask

and similarly ask drivers to specify the mask behavior and preferences for customers and then match drivers and customers appropriately?
> Polish pilots could land them (unarmed) at a Swedish civilian airport

Sweden doesn't even want to consider joining NATO at the moment, do you think they would be up for such a diplomatic sleight of hand?