skysight-inc/HackerNews huggingface dataset:
It apparently has thousands of copies of the same DNA. That makes it sound like calling it a single cell is a technicality based on how the multiple copies of DNA aren't separated from each other, but it isn't necessarily a single cell in an interesting way.
The article is terrible and at least the 2015 study makes bigger claims than they really ought to considering the scope and sample size.

>Fructose enhances liver/body weight ratio and kidney weight; soybean oil is protective in spleen and kidney.

From the caption on fig 2.

>To our surprise, we found that at 20 weeks the F-HFD did not cause diabetes (fasting blood glucose level > 200 mg/dL) whereas the SO-HFD did (Fig 4A).

This is in the results section as well under what I hope is just the heading and not an actual conclusion they drew: "Soybean oil induces diabetes, glucose intolerance and insulin resistance (IR)"

That's enough to give me some serious pause. If anyone has an explanation for why they felt comfortable claiming such certainty from the trial, I'd love to be wrong about this. It looks like you could just as easily claim that coconut oil prevents these things from the data provided.

I also am curious where the fructose + soybean oil + high fat diet group went when they started doing genetic analysis. They just disappear. Maybe I missed it, but it doesn't seem to be addressed in materials and methods or in the conclusions.
Live Radiological Maps in Ukraine
Listen, I'm all for a new orchestral library/soundfont (it's no easy task making one), but the screenshots they're sharing do not make me hopeful for the future of the software. I think Muse Group has good intentions, but much like the GNOME foundation and Canonical, I feel like they're falling into the trap of being compared to commercial software. I think Tantacrul's critiques of the modern composition stack are fair and warranted; I'm definitely glad that people with strong opinions are stepping forward to fix things. But these menus just evoke a feeling of being trapped in Adobe Purgatory. Their logistics choices are starting to lean on the harmful side, too: peer-to-peer downloads by default, intrusive telemetry packaged in from the start, ridiculing forks, not licensing the download hub as open source... it doesn't make me excited for what's coming next. This new development/design philosophy only encourages me to stick with older versions of software.

The silver lining to this cloud is that it's still OSS, which gives us a fair bit of leeway for changing the things we dislike. I'm just frustrated that this trend of kneecapping software experiences to make them comparable to commercial solutions has started to infect open-source.
Call me what you wish, but it's not true. If you're done then log off and stop spamming your replies to every single comment in this thread, and leave some space for any other opinion. You're just ranting
Point taken on how for_each works for linked lists. I'm (obviously) not a C++ expert and it shows in that context.

I suppose the thrust of my opinion is that a lot of code depends on the fact that it iterates over a linked list, which is safe in many contexts. The idea that callers could substitute container types which break its assumptions seems unwelcome to me. Nobody provides the wrong fields to list_for_each_entry because they get very nasty compiler errors if they try. But anybody can plug a new container type into a for each statement and get new behavior that silently breaks the assumptions of the original code.

I suppose that could be protected by a better type system though. There's a lot to improve on C even for kernel dev, and "C is greatest" isn't a hill I'm willing to die on :)
>Russia needs them there, so they took Crimea proactively
This is a weak argument. Why can't they build their own port on their own land?
There are a lot of people here suggesting that Google's SSO should be avoided.

Those people are wrong.

If your email address ends in @gmail.com, then you don't control it, and have committed to tying your identity to Google's whims. And that's okay!

There are certainly some issues with Google unilaterally blocking access to accounts, but (1) this is extremely rare and (2) honestly, you're screwed even if you're using a password manager in that case.

Why? Because "password reset" is effectively SSO tied to your email address. It's just less secure and harder to use.

Seriously – under the covers, OAuth and other SSO flows are virtually the same as the process of opening an email and clicking on the link, except that they've been vetted by security researchers where "reset password" emails are almost never actually secure.

Password managers, for the vast majority of people, are confusing, unreliable, and even dangerous. Backups are hard to manage, and people often get it wrong. Forget your GMail password? Google will accept government ID and get you back in. Forget your password manager's password? Too bad, you're out of luck. The latter is vastly more common than Google blocking people and refusing to let them back in.

To be fair to HN, there are a few good points in the responses here:

- @linsomniac does raise the good point that you're likely to need a password manager in any event, since some sites don't support SSO.

- @jaywalk points out that if you have an email address on a domain that you own, you're not dependent on Google in case they refuse you service. It's worth noting that in this scenario, using Google's SSO is still fine – if they lock you out, you can still access any accounts you used SSO to sign in to by using password reset. I have yet to see a site that doesn't allow switching from SSO to using a password.

One thing to add is that you should never use Twitter or Facebook SSO; if you do, and get locked out of (or want to delete) your account on either service, there's no recourse whatsoever, and there's no way to switch to a password because your account often isn't tied to an email address if you go with Sign-in with Facebook. Same goes for LinkedIn and other similar "Social Sign In" systems.
In the context of the parents comment I thought they were comparing that model to others where multi selct exists.

I don't think there is a much better model on mobile, except possibly adding a button to each item to select a longer span.
Also selling chips at a set MSRP and then offering to unlock the "full" potential of the chip for a low monthly fee.

It would be like buying a car and having to pay $20/month to have the 65mph speed limiter turned off.
Unrelated to the article, I also enjoyed the layout of the blog
Please don't use or support Flutter. Its entire existence is to replace the web and force more ads to people. Do your research.
Nope. I'm in a hardware-dependent job. I've been WFH at both this job and the previous one.
I just run into the office occasionally if there's a board re-spin.
Apologies if the post comes off sensationalist. I am not currently actively taking these steps as I don't perceive a significant threat. That's as a lay person. Having said that, it may be helpful to have something in mind if the unthinkable occurs.

In case of issues with gov infrastructure, here are two more backup links:

https://web.archive.org/web/20190101153955/https://www.ready...

https://nuclearadvice.org/
I used to find it boring. I always wanted to be objective, and not just say "you have to do it because I said so". I had to dig deep on every one of my gut feelings. I had to do a ton of unpacking of my own instincts. Sometimes I had to correct my own advice when it went from good to bad due to some contextual change that I haven't predicted. Other times I had to argue against good practices that are commonly accepted, because turns out, they aren't always good. Once I realized that all of this stuff has objective underpinnings, and can be unpacked down to some foundational reasoning, the whole thing became incredibly fun. My brain became preoccupied breaking down complex subjective ideas into simple objective ones. Like I got my own source of content in my head. It got especially exciting when I succeeded unpacking some long-term architectural advice that doesn't have any short-term benefits. Not everyone is into that kind of thing though.
It's called the Daniel K. Inouye Solar Telescope, by the way, because Daniel K. Inouye took out three Nazi machine gun nests by himself, and while throwing a grenade at one, had his right arm shot off by a Nazi rocket, obligating him to pull the still-live grenade from his now-severed hand, and toss it into the bunker. As one does.
Happy to see it in HN, if only as a canonical example of the current “rage” of reductionist n-of-1 science funded by you and others through NIH and many other research funders. This is the very opposite of robust and translatable research. It is science to “get a paper out” with a snappy press release.

Would you trust n-of-1 clinical trial? One monozygotic twin gets diet X, the other is control. A study of C57BL/6N mice, no matter how many are used is an n-of-1 study. And these mice all completely inbred. At least the human MZ twins are not inbred!

There is just no excuse for style of reductionist science. Gives mouse models a terrible, but perhaps deservedly bad reputation for translational ir-relevance.

Yet you see these n-of-1 studies in many of the top tier journals. The NIH BRAIN initiative mouse studies make the same error. Do we really want just ONE connectome? How do we compute our way to causal models with n-of-1?
Why are most US market indexes up today?
> AMD® Ryzen 9 5950x, 32 GB RAM, Linux/Fedora 35, Firefox 97.0, Chromium 96.0.4664.110

Same CPU in my Windows workstation and it's plenty smooth. Not just usable, but smooth. This is at 4K.

Do you have a modern GPU, or something quite old? Or do you have browser hardware acceleration disabled?

If not for your GPU, it's also possible that Linux simply performs significantly worse than Windows for whatever reason.
This mostly seems to funnel people to various Google things. Hover over it and you might get…

- I'm Feeling Doodley: Google search for "google doodles"

- I'm Feeling Puzzled: redirect to http://www.agoogleaday.com/#date=2012-02-29

- I'm Feeling Trendy: redirect to https://trends.google.com/trends/trendingsearches/daily?geo=...

- I'm Feeling Artistic: redirect to https://artsandculture.google.com/asset/xwE7rgYgnWm68w

- I'm Feeling Adventurous: Google search for "roll a die" (with die rolling widget embedded above search results)

- I'm Feeling Playful: Google search for "tic tac toe" (with tic tac toe game embedded above search results)

- I'm Feeling Generous: redirect to https://play.google.com/store/apps/editorial_collection/prom...

The only one I've encountered that does't send people a Google site or widget is "I'm Feeling Stellar", which is just an image search for "reflection nebula".
Dang commented on this[0]. It's intentional.

[0]: https://news.ycombinator.com/item?id=30041122
I believe the commenter is referring to system where you take a giant “git sed” and automate a rather complicated process: 1. break up one huge diff into a set of many (hundreds or thousands) patches, where each individual patch only touches files in a particular subsystem. 2. send all those patches to the appropriate system owners and run the appropriate tests. 3. manage the actual merging of successful patches, as well as communicating to the original author any individual patches that might need more attention e.g. based on patch review feedback.

as you might imagine, it’s probably a pretty involved process to touch thousands of lines of code in a complicated system.
It needs a boot labeled "Putin."
You are wrong here. Even if you think that "everyone" is talking about it, you may be actually in the same filter bubble as on all the other networks.
That's not a sustainable approach as these old APIs will be obsoleted by a future version of Android. The correct approach is to follow modern practices that will guarantee security & privacy. In the case of Termux, they're well aware of the issue:
https://github.com/termux/termux-app/issues/2155

This is a similar situation to iOS which has a saner app ecosystem for this reason (in my opinion). That doesn't prevent apps with the same purpose to exist. iSH and a-Shell are examples of that on iOS. UserLAnd on Android takes the proot approach: https://userland.tech/
yeaaahhh... not sure about that, chief
It's more that it's possibly ending up in the hands of the Chinese government. Not that it's good when it ends up in the hands of Google, but that's less of a national security concern.
European countries have not neglected anything. The current state of things is by design.

Europe used to be full of empires waging destructive wars all over the world. After two world wars, people had had enough. The predecessors of the EU were created to tame the former empires. To make them mutually dependent and act like ordinary countries. It worked, and Western Europe has enjoyed a lifetime of peace, which is unprecedented.

We Europeans are shitty people. If you tell us that it's ok to start acting like empires again and to send troops to fight wars far away from home, the world will have more than one Putin to worry about.
Just published exempt from the quarantine obligation:
https://twitter.com/a_niedzielski/status/1496963713676595201
I think there's a huge difference between a 14 year old and an 8 year old.

Also there's a bit of cultural assumption going on here. Based on the amount of comments, the poster's child is probably a native English speaker. My nephew is not, and has only begun learning English in school.

If the goal is "Let's make something for my child" that's cool and needs no change. If the goal is "Let's make something to help children learn programming", a more difficult and noble goal, then removing barriers such as English fluency, is a way to do that.
Likely because it's considered "Googley" within the company.
given that Russia has serious aspirations to take itself off the internet, it's questionable what effect cutting Westerners from Russian sites is supposed to have

https://www.bbc.com/news/technology-50902496
Have economic sanctions ever succeeded in altering the behavior of authoritarians? It pretty much always just ends up impoverishing the normal people of a country, which authoritarians do not care about.
> withdraw forces which would look like huge humiliation

This is much less relevant for a constitutional democracy than for a dictatorship.
AMD, as far as I know is a GPU/CPU maker so how is mining crypto with ASICs even relevant? Ethereum is mined with GPUs but I think that market doesn’t have a lot of slack with or without crypto.
Absolutely amazing documentary with the same title.
youtube.com/watch?v=NlpZRBi5xQg&list=PL5rPE79bMQWey_LaeDcJo4F4eslYLTKbg
Looks like it skips the ads entirely. Quite lucky.
It's not an hypothetical, WWII historical content has been systematically epurated last five years.
DuckDuckGo still has this, but it's not in the form of a button. Instead, if you prepend a backwards slash (\) to your query, it'll take you to the first webpage in the list of results. This is done server-side, so it also works in your browser's search bar.
What body temperature are all these torpid people maintaining then?
Ah, but the thing is. They haven't violated the letter of the agreement. What they have violated is the spirit.

This could of course be blamed in Ukraine for not rejecting it at the time.
There is literally a link in the article that takes you to the Debian website: https://wiki.debian.org/Teams/Apt/Spec/AptSign

I might rephrase that since they didn't technically moved away from OpenGPG (yet). It was a proposal at the time.
There appears to be satellite imagery of Russian columns passing through the Chernobyl Exclusion Zone, which would support this thesis.

https://twitter.com/CSBiggers/status/1497000126719606790
I waited for the Real Life blocks to turn white. Such a nice touch.
Well? What do you have to say today Herr Schueller?
This is what's keeping me from using a wework membership. At home I have a second monitor, my external mouse and keyboard, my aeron chair; and if I need a change, i can go work from the kitchen.

Even if my company opened the office again, I've now got all of the ergonomics they can offer with no sneezing colleague next to me. And it's on me if there are dishes in the sink or the coffee needs a rebrew. Plus, at least one member of each team is geo-remote, so every meeting will be a better experience without being "hybrid"
> and secretly think they're nuts, but: different strokes for different folks

I don't know. I'm switching next week to a fully remote position, partly because of the fully remote work aspect. I am looking forward to work in a team that can handle asynchronous and well written communication and use that by default because I think that's way more efficient for me and such a team. I'm also looking for saving the commute time so I can spend more time on my own things and friends, the possibility to take breaks at random times in the day, the possibility to cook for lunch if I haven't had the chance to cook the days before, and many other things.

However, I have been enjoying my last days in the office at my current position, in particular the in person discussions, lunch and peer programming. I appreciate that people are seeking this. I also know people who just can't focus very well at home, and that's not always because of the children. My flatmate is one of them. I don't think they are nut for preferring office work as a consequence.
And I should add — I do these kinds of studies, and have since 1996. I love using mouse genetic models. They can be great.

I always try to study many genomes of mice and whenever possible both sexes.

Does it make it harder and more expensive? You bet. But the data are much more robust and translationally relevant.

See almost any paper by RW Williams at UTHSC.
It's a good question when that happens. And if we knew for sure that that was what was happening here the moral calculus would be clear. But we don't know for sure. I think because we live in the shadow of WWII and because states so disproportionately educate their children about WWII that we often overestimate how often that kind of moral imperative rears its head. For every time in history that a country invaded another with the intent of total domination there are a hundered times when countries invaded other countries in a limited way, to shore up their frontiers, to affect a balance of power, to acquire a spcific resource, or to satisfy some portion of their population.

Limiting Russia's ambitions doesn't make this kind of thing less of a crime. Our commitment to self-determination and anti-colonialism that we inherited from those who fought WWII shouldn't waiver. However, we should be cautious to discuss everything in the existentialist terms of WWII. America's last 70 years of war making should teach us that if anything. There is no shortcut to moral clarity in foreign affairs. Unfortunately you can't achieve justification of violence without letting the belligerents show themselves prove its necessity.
I was able to save up enough money living in CA to pay off a house in a cheaper state. Now I just pay property tax, which is a little less than $500 per month.
Why would China shut off Russia when it also faces the same adversaries from across the ocean? This is their moment prove CIPS.
Somehow the discussion shifted away from the original topic...
Moving away from Windows – It begins
Official NATO stance, as President Biden has repeatedly said, its to defend EVERY INCH of NATO territory - so if Russia parked one tank inside of the Polish border, all of NATO is at war with Russia.

If NATO does not respond with force, or escalate and withdraws because of MAD, then it loses all credibility.

The question is: Can belligerent nuclear armed nations really hold the rest of the world hostage? At some point, it's unacceptable, and we would all pay the consequences.
It links to this previous submission from 2019: https://news.ycombinator.com/item?id=20105567

Likewise, it was "product of the day" on Product Hunt, that day was June 6, 2019.
Did I say there were two definitions? I said there are two declarations. Try using a function with a return type other than int before it has been defined or declared in C and see what happens when you compile it.
Well that’s not how anything works. E.g. how many babies might be saved by Russian economic development from having access to the sea through Ukraine? At this scale the moral calculus isn’t easy.
A language picker with translated languages using wikidata
Source is pretty partisan, as are the sources cited in the article. I was hoping for better, more rigorous reporting.

Quick skim - https://brownstone.org/tag/public-health/
Well this is interesting: my perspective is that we are actually already living in the age of the bureau and the technocrat, with only some vestigial democratic traditions, and we have been since 20th century wars. Burnham (who is well worth reading, in my opinion) called this the "managerial system". Of course, it still calls itself "democracy" despite not really being democratic at all. In fact, whenever you hear the word "democracy" -- a word which tends to have positive valence in society -- in the official press, you can substitute "managerial system" for a more neutral term without loss of meaning.

That age might be coming to an end, but it's less about some vague general mood of the 2020s and mostly due to proliferated networked communications. This allows people to find their frens exchange ideas and coordinate actions. Oh and everyone starts to see how transparently duplicitous the official lines are.

We perceive all this as "populism." From Arab Springs to meme stocks to Donald Trump, the phenomena are clearly a form of network dynamics. Is it bad? Is it good? Well... it's certainly disruptive, and is probably both good and bad in different cases and at different times. Which are which depends on your point of view.

But disruption of any kind is certainly bad for the managers, so the natural reaction is precisely what you suggest, effectively, sinification: tighter control ("moderation") of online communications, suppression of opposition parties. Policy drafted by career mandarins. The CCP has done alright, so I suppose if (big if) they can execute it well it might buy them some more time.

But unless you are a party insider, I'm not sure why you would throw your lot in with them.
What "consequences ... such as you have never seen in your entire history" are you imagining he's referencing? Threats can be clear without using the very specific wording you're demanding.
This is completely absurd. The density of air is about 1/1000th the density of body tissue. The effect you are talking about there is negligible, and would remain so even if the atmosphere doubled in mass (hell, if it increased by a factor of 10).
Wasabi Was “Demixed” by Chainalysis
> Really? He kept threatening sanctions, kept saying the invasion was happening...

I'm confused by how this is antagonizing Russia. By saying what Russia was actually doing is the reason they kept doing it?
It's like the last little bit of personality Google has left.
Do we really need the fancy new word "metacognition" when we already have the plain old word "epistemology"?
Below I've written a response but first would like to add this preface: I am having trouble wording what I am trying to mean properly and have struggled. I did my best, abusing a large amount of scare quotes, but its not perfect. If you need clarification just let me know.

I believe you have created, in my estimation, a false dichotomy. You frame those involved in "January 6th" as "insurrectionists" while also framing the entire Floyd saga as "protesting police brutality". The Republicans, in my personal interactions at least, specify that they opposed "riots" and many have said they aren't reffering to all of the peaceful protests. They don't appose "protesters" but "rioters". Conversely, again in my personal experience, Democrats will frame the "Jan. 6th" events as an "insurrection" unilaterally.