skysight-inc/HackerNews huggingface dataset:
Of these the PD-L1 and MABs are the most advanced, a number with FDA approvals and used as standard of care for a few cancers. Side effects can be nasty but often controlled by backing off the treatment or steroids (most problems are the immune system attacking the wrong thing like thyroid, colon, pancreas, etc). They’ve been game changing with nearing 50% success rates for some cancers - hence the Nobel prizes. But that still leaves 50% or more.

mRNA as a platform is really exciting, but most current trials are personalised and very labour intensive, so intake/trial sites are minimal.
I read here on HN that Google has come up with new way to buypass all trackers and adblockers and I think things are going to get really bad for web.

I think it's time we build a directory of applications or a search engine which indexes only the websites that do not use any trackers. The damage of tracking industry to whole web is irreparable but I think we have an opportunity to build a new web that can have mechanisms to prevent any sort of tracking.
Programming is mostly r&d and i dont hear people trying to automate researchers, rather enhance what they can do.

I'd argue if a programming position can be automated, that position wasn't needed in the first place and someone can make better infrastructure that doesnt require it in the first place. But to build that infrastructure you do need competent programmers, and if you dont a competitor will, and eventually replace you.
I agree that this will be a next level of getting owned same way Facebook was next level of getting owned (in comparison to web pages and disjointed services). I vividly remember trying to send some message to a friend over Messenger and getting blocked because of something Facebook didn't like in the message. Don't quite remember what it was. Maybe a computer program, maybe a link to copyrighted content.

> ... virtual sewing machine doesn't allow you to make that design because it violates community standards, maybe by cultural appropriation...

In this world you can still make all the stuff you physically can if you let anyone see it you might get all sorts of backlash from "the community".
Agree on the first 2, the 3rd is questionable, but the best wine ??

I'm sorry, but when it comes to fine wine, it's France, then Italy, then everything else. And it's not even close.
Sounds quite similar to my accountants-example, doesn't it?
>Actively applying and interviewing, still receiving absurd requests to resolve various quizzes, teasers, and assignments. Potential salaries top at miserable 70-80k EUR in countries where monthly salary deductions reach 40%.

Let me guess, France/Austria/Belgium?
Even if you don't bring in C, you need a cross linker and some libraries to link against. Rust doesn't come with those, except maybe for the mingw target.
Oh come on folks. If they do nothing "look at them lazies". If they give fines "look at them incompetents". What exactly should they do to stop those practices and look good in the eyes of HN?
There is a British company called SafetyNet producing products to make fishing more sustainable (I have a friend who works for them). One product is a light intended to work exactly in the way described here:

https://sntech.co.uk/products/pisces/
That’s correct. The filling is free for everyone. The tax preparation is not.
No one can win against kipple, except temporarily and maybe in one spot.
Using Markdown with pandoc and pandoc-crossref is basically perfect as a substitute of LaTeX. It allows in-line and standalone LaTeX, and citations with crossref.
> Their audio captcha (no longer available?) involved listening to 3 MIDI tunes and picking "the sad one".

Given that a large part of the world doesn't use the major/minor dichotomy, or even equal temperament, this seems like a terrible way to verify someone is a human...

My favourite recaptchas, if one can have such a thing, are the shape sequence selection ones as they don't make significant assumptions about culture or education.
> We're still attending stand-ups every day with non programmers telling us when we can and cannot refactor. It's nuts to me that a skilled profession - that not many can do - lets themselves get micro-managed like this.

This is actually quite interesting as I was just talking to a few other professionals about this in a social setting. I was the only one in software development.

I mentioned how stand-ups work briefly, and that it might not be a bad idea to adopt for (for example) an accounting department to keep things on task.

The response was both extreme and universal: How the hell do you all accept being micromanaged to such a degree? Don't any of you have any dignity?

Every single one of them (all professionals, like I said) were adamant that they would leave any position that managed them no better than a burger-flipper.

No lawyer, accountant, doctor, engineer, scientist or other professional stands up each day to report *to their peers* on their progress.
Somebody tries to break into your house 10% of the time you leave?
Seems like an apt analogy - adding in friction for the small minority of instances where someone would undertake an action you don't want them to. Not literally "if I don't make someone choose 5 firetrucks out of 9 pictures they're going to steal my stuff".
> but everyone cycles

This is probably the key. A cyclist behind the wheel will usually show some consideration for other cyclists. Same for motorcyclists.

Besides, there are just more cyclists in Europe in general. Drivers are used to seeing them, and driver training accounts for them. It's easy to hate the single cyclist on your commute, but when there are hundreds of them, you must accept their existence.
Did not know this, just enabled all of them. Thank you!
You can subscribe here for whenever it happens: https://github.com/dessant/buster/issues/320
As much as dark mode is becoming a thing, I can't read light on dark text without it messing with my eyes. It has to be the worst way to render text.
In practice, research and experimentation is done to work out the right combinations of light colour for the particular sort of fish you are trying to catch, and then fixed light sources are built for that. In some cases the roll-off from colours you want to colours you don't is quite sharp and that's easier with fixed illuminators rather than RGB.

Edit: I have a clearer way of explaining the challenge. We are used to 'any colour' being possible from RGB style LEDs. That is one resolved colour that we perceived. But for this we aren't trying to achieve one colour, we are trying to configure a particular spectral output. You could maybe get close to that with lots of LEDs across the spectrum, but it's not the same as well designed cluster.
If you want to support the fight for privacy in EU, consider supporting https://edri.org.
Oh, this question is decades old and I believe 15 years ago it was still solved by an *asterisk:

"Answering yes in this question does not disqualify you from receiving a visa".

People entering US from other countries are treated like shit regardless if they have visas or their countries apply for visa-less process. Both of those suck, you are treated like a criminal from the very first meeting in consulate, they take your fingerprints and you still have a decent chance of being put back after arrival. Business visas are more pleasant but it was for so long just "pay for more predictable process" and still has a lot of flaws.
In what city do you live and what languages are you seeking?
> can bite you back quite bad

Curious to hear what you mean by that?
Yep. Stray dogs hate my motorcycle.
article definitely made me think about what else I could be 95th percentile in. I agree that dedicated practice is very important compared with people that just play casually
Source: https://www.reuters.com/world/us/exclusive-trumps-truth-soci...
That's the ironic part, machines are able to solve these just fine so they defeat the purpose entirely.

I wonder, does recaptcha work with your google account? Because at some point a lot of people will end up doing some kind of identity verification on there. But I think Google and co can make a reasonable assertion about being human by looking at activity across said Google account - location, emails, documents, etc.
Nydus – Acceleration Framework for Cloud-Native Distribution
Nydus is an acceleration framework provided by the Dragonfly (CNCF incubating project), it implemented a user-space filesystem to build a high efficient read-only data distribution system for Cloud Native workloads, such as container images, software packages, etc.
> the laws are teethless if they are not enforced

https://www.enforcementtracker.com/
Thank goodness for firefox reader mode.

I don't like seeing white lines as an after image on my retinas.
So this is the new social platform that fact checks every post then /s

…well I typed that as a joke but I’m reading their ToS now and find this:

> If you provide any information that is untrue, inaccurate, not current, or incomplete, we have the right to suspend or terminate your account and refuse any and all current or future use of the Service (or any portion thereof).

https://help.truthsocial.com/legal/terms-of-service/

(Note to truth staff, links to Privacy Policy and ToS under the signup form both 404, had to google to find them)
Go along the canal tow path between Hackney and Islington if you want
to see humanity at its lowest :) You'll find;

Walking Pedestrians

Runners

Cyclists

Mums with buggies

Latte drinking hipsters

You could devise a Rock-Paper or Top Trumps type game where each has
their own agility, velocity, hit-power, hated outgroups, allies,
special powers and so on. The most aggressive by far are runners. They
literally hate all other groups and will deliberately elbow you in the
ribs or push aside anything that gets between them and the new
high-score target time.

Buggy mums have a special power of vulnerability, second only to
wheelchair users that can, like Moses, part the sea of apologising
docile bodies (Everyone in London is constantly "sorry", simply for
existing and being in other people's way. But "sorry" is actually a
very subtle and British form of "Fuck you").

Cyclists vary between extremely polite and conscientious folks who
gently ring their bells and pass single-file in groups... to absolute
assholes. How expensive their bikes are more or less directly
correlates with abusive behaviour. The optimal bike in London costs
about 50 quid and is a fashion item that demonstrates you have nothing
to prove. Anyone on a £400 mountain bike is almost certainly a total
tosser.

Pedestrians, necks craned, heads down in their smartphones. earbuds
blocking out any warning shouts or cyclists bells, zig-zag across the
path while reading Facebook or scrolling on whatever dumb new app they
have.

And you don't need to be fast moving and dangerous to cause chaos.
Hipsters literally sit in the path, man-spreading their legs across
the lane, daring anyone to interrupt their beard-stroking and spill
their latte.

On a good day this is all a cosmopolitan good natured jossle. On bad
day things get violent and people get thrown in the canal.

The point is, that heterogeneous users in crowded transit paths don't
work well together. Amsterdam is another good example, but has a
different dynamic once you mix-in ten-ton trams. Car drivers are just one
more level of removal. With cars on the roads it's life and death, and
scores of cyclists are killed every year in London.

We recently changed the Highway Code in the UK to give pedestrians
(and cyclists) far higher priority over cars. But, like using phones
while driving, nobody pays the least attention, and laws are barely
enforced in Britain anyway, which is a good and bad thing.
> U.S. claims...

You can pretty much disregard whatever comes next. Then.
boohoo, you only earn 70-80k EUR bruto. And you get to live in Europe as well?? You realize the average bruto salary in (west) Europe is around 20-30K EUR? Even lower in east Europe? You are one of the luckiest, most privileged people alive. Yes, there's always a bigger fish/higher salary. But christ, get some perspective.
Plumbers are in high demand too, but if you are a plumber with depression, lack of experience, that doesn't want to touch waste pipes or shower units, and live in the sticks, it won't apply to you either
>When I hear "programmers are in high demand", I don't see it applying to me.

This is a very nuanced statement and depends highly on region.

When you hear "programmers are in high demand" it actually means "senior/experienced programmers in the company's stack who can quickly solve the issues piling up on their desk, are in high demand".

Juniors or devs with near zero experience in that particular stack are getting rejection letters as most companies never consider on how transferrable dev skills are and prefer to wait until the perfect dev shows up, instead of giving someone new to the stack a few weeks to ramp up.

At least that's how it is in my current country of Austria, but back in Eastern Europe, the demand for devs is so high due to US off-shoring and Western EU near-shoring, that companies will hire absolutely anyone who can write a for loop and even give them trainings to ramp them up quicker. It's literally impossible to be unemployed there even as an inexperienced slow learning coder. Sure you won't make six figure salaries, but you'll live far more comfortably than 90% of the population.

IMO, just like in dating and real-estate, the dev jobs market is very much about "location, location, location".
Millennials are now old enough that they grew out of fantasy of never getting old but haven't yet grew into the fantasy of believing that aging has some value. That aging it's something worth doing. Something that we wouldn't get rid of in blink of an eye if we could.
Gravity is not hard sci-fi. It looks amazing in 3D but it violates the laws of physics in every way possible.
I don't think it was right or wrong. That is the wrong lens. I just think we need to arrest them after a certain threshold of harm. Here's a reductio ad absurdum of the position that all economic harm should be tolerated: Should we allow a small group of 5 protestors to blockade the tarmac of an international airport and shut it down for 10 years? On what principle would you prevent that if you have declared support for protest irrespective of economic harm? Clearly this rule of yours doesn't work. The protestors need to get arrested at a certain threshold of economic damage and every thinking person should agree with that.
Thanks for mentioning. I made a comparison with it - https://github.com/fatkodima/online_migrations#cool-but-ther...
I have never seen an ad in Windows. Where exactly do they appear?
I run a community forum and have done so for over ten years. Spam accounts is a regular occurrence, but thanks to various services (akismet, stop forum spam), captchas, and simple word / behaviour filters (anyone with <10 posts that tries to post a link or image gets flagged) we've been able to avoid our users from seeing much spam. There's a few that come through, I wonder if those are real people.

Anyway, at one point we decided to just block the IP ranges from countries like Russia and Vietnam, which seemed to have the most spam accounts.
20 people is about a school class. Being the best at something everyone does in a class is rather hard.

If you suck at skipping rope (I did) you could probably climb the implicit rank quite easily by practice, till you were up against the sporty girls with aptitude.
> No lawyer, accountant, doctor, engineer, scientist or other professional stands up each day to report *to their peers* on their progress

Doctors do something not far removed. It's really important to them to caucus on case management.

I think other professions may do the same.
The Chinese government is concerned enough about a rise in short-sightedness due to kids being made to spend long hours in cram school, and were considering various measures to make them go outside more.
One thing I loved about Palm was the reliability of the handwriting input. It forced you to get used to the shorthand alphabet, but once you did it was so easy to take notes without even looking down. For awhile I had an Android mod that let you scratch notes using Palm script, but I don't have it now (or a phone with a stylus). For me, writing in Palm script is still almost as fast as jotting notes on paper. Come to think of it, I think it actually altered my real handwriting.
I saw this one today, which asks you to pick a "cheese" illustration: https://imgur.com/a/fQSQpX4.

I'm very much of the opinion that almost all modern captchas are american-centric. Mailboxes, fire hydrants, Trams are not recognizable for billions of people.
I have almost 7000 rules for a 260kb file ;)
I'm not sure how effective an AI would really be on this. Distinguishing from a pattern on top of the dice vs a pattern on the side/front seems like it would actually produce a lot of false positives.
I have cameras built into the lights on my bike, front and rear plus a second light with radar on the back.

When I told my family this my, normally quite friendly, brother-in-law asked why.

I told him that it's not unusual to be threatened by drivers when cycling. Anything from close passes that make you jump to a passenger leaning out trying to put a plastic bag over my head.

He got quite angry and proceeded to tell me that cyclists "bring it on themselves and deserve what's coming to them" ...and we get on.

If I suggested waving a baseball bat at strangers on the street he'd rightly think I was mental but apparently if you're on a bike you're fair game.

It's not that unusual for randos I meet socially to say something like "lycra-clad MEN!, it's always men![1], need to get off the road and pay road tax![2], and stop riding through red lights[3] and wear NORMAL clothes![4]"

I could argue with all of that or call them an asshole but what's the point? It's best not to say anything.

It's not about truth or statistics it's about othering an out-group, cyclists and not feeling bad when you scare or hurt them.

1. I ride with lots of women in my bike club. They get just as much hassle but there's generally less kudos at parties in bragging that you tailgated the shit out of a lone woman because she was wearing tight clothes.

2. Road tax in the UK was abolished in 1937. No one here has to pay it and like most cyclists I also have a car.

3. As a point of pride I never ride through a red light but I do see drivers tailgate through red lights or on the wrong side of the road every single day.

4. If I'm going to get sweaty why wouldn't I wear comfortable kit? It's not like I wear a pair of jeans and a t-shirt to go swimming either.
Purely numerically comparing it, assuming slavery counts as a life spent in suffering, and there's a 1:1000 factor, given a forty year life expectancy, Google must cause the equivalent of 14 slavery-equivalent-suffering-days or more to be worse.

How many days of back-breaking labor and abuse would you put in to get freedom from Google tracking for the rest of your life? For me at three days, it'd be arguable; three weeks would be a stretch. (Of course, I have no actual experience to compare.)
Applications worked offline, they made good use of available system resources in exactly the same way that modern "web apps" do not.
> Yeah that sounds like the easiest way to make your colleagues hate you

Well I'm not Whitney's colleague but I really like his code.
Thank you sir for you support.
It help me a lot to understand about email and spam relate.
Last question if you dont mind
Do you suggest any forum for me to ask these kind of question? Forum can be access using tor or something ?
I've developed a methodology of throwing it away on receipt :)
The GDPR applies to everything outside of purely personal/household activities - it's not limited to websites.
Pause Any X11 Application
Old stools broke as well, but the ones that broke don't exist any more. Only the really good ones remain.
You think installing cameras on your own property is stalking? Putting aside that this is legal nonsense, are you saying that the millions of private retail stores, offices, and houses that install security cameras are actually stalking and the majority of citizens that visit grocery stores are stalking victims?

I mean, maybe you do believe that, but it's a little ridiculous to freak out over something that most people do and are used to. At most, it's an extension of the status quo.

Edit: I suppose it's not that ridiculous if you think most of the world is evil, but I am genuinely curious if you believe that.
Depression will distort your vision of reality and make things look worse than they are. It will also make it much harder to take even small risks for greater gains.

In all likelihood, you're stuck in your position because you're limiting yourself in some ways. I'm not saying it's easy to get out of, I've been there, it's not.
Ask any digital nomads, and if they're not "bromads" they'll be usually ok to admit that they've experienced - at least at one point - a specific form of depression, mostly due to having to deal with all that comes with a self-imposed nomadic life (fleeting in-person relationships, lack of a stable community, lack of feeling "rooted", finding out how hard it becomes when you have to deal with serious health issues, and so on).
GNU makes great software that is seldom marketed or talked about. That's a real shame because Taler looks like something I'd be happy to use compared to Apple/Google pay or Crypto.
> I'd like it if the links would open to a new tab by default without me needing an extension

You don't. Just - while hovering over a link, click on the middle mouse button. Works everywhere. You're welcome.
Thanks for the clarification on that. Either way, MAI v. Peak was kind of a disastrous decision that presumably could have easily been resolved under fair use for the service contractor. Congress included Section 107 for a reason, and no doubt part of the logic is that courts use it instead of creating a make work program for Congress on the subject.

That would seem to go double for whichever court decided that ephemeral copies in RAM are "fixed" in a "tangible medium of expression", in direct contradiction of the plain meaning of the term.
That’s pedantic and not even that right. The browser is an agent, not a bot. A bot takes semi-autonomous actions after being instructed by a human, for an undetermined amount of time; A browser just does something it’s told for a few seconds (or as long as the website’s open)
I think of a reverse proxy as more of a general architectural pattern - when you have cross-cutting concerns for an application with a relatively broad protocol (HTTP) you can implement them as a networking layer in front of the service(s). Indirection and abstraction are powerful tools in computing.

Common reasons for such a split:

1. Composing several different services into a single internet domain

2. Putting stateless or CPU-heavy workloads onto different infrastructure from long-lived, IO-intensive tasks

3. Variation of the above, allow for multiple server processes in server environments which can't scale up to single multi-threaded processes well (CRuby/CPython)

4. Split security concerns off onto a box which has a much smaller attack surface, such as a box meant to be deployed in a DMZ (examples would be HTTPS termination, authentication and authorization policy enforcement)

5. Caching of responses (this is Varnish's claim to fame)

6. Variation of the above, some CDNs work by hitting an otherwise private server for data, then replicating throughout the network for locality to end-users.

7. Application-specific behavior patching, such as adding new API endpoints or changing the behavior of existing ones

In many of these cases, people use something like NGINX, Apache or a commercial solution like an F5. In other cases (such as application-specific business logic) people will write their own code, perhaps in the future using this Microsoft project as a starting point.
Yeah, where do you stop when you start adding fonts to Unicode?