skysight-inc/HackerNews huggingface dataset:
I have been reading a book recently: The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug, and one of the most fascinating parts was the way they discovered this molecule. Long story short, Taxol is a molecule they isolated from the bark of the Pacific Yew. The interesting part for me was learning about the Cancer Chemotherapy National Service Center [1]. They went around collecting samples of random plants, then tested them for anti-cancer properties very systematically. So in the U.S., at one point, we had a publicly funded drug discovery program targeted at a specific disease, and this is what jump started Pharma research in anti-cancer drugs. I would say we need to restart a program like this, and of course we should also focus on rare diseases--we stand to learn a tremendous amount, and it's difficult to convince industry to do it.

Personally, I'm a computational/mathematical biologist and I work on single cell data targeting multiple myeloma, I'd really like to see serious non-profit Pharma. Drug repurposing seems like the most feasible avenue. What I know of right now is open Pharma [2].

[1] https://dtp.cancer.gov/timeline/flash/milestones/M3_CCNSC.ht...
[2] https://www.ospfound.org
It does run, not even sure if you need to slim down the kernel (I managed to find 128MB of RAM for my P166, 3 years ago it was enough for the regular installer).

It was nice to run modern software on it, it was an ok-ish terminal, the CPU struggled (a lot) with default SSH cryptography and the graphical mode was not of much use, but it supported the serial mouse, which is nice
Yes I'm vaccinated and boosted. It didn't really help. Got my second shot March 2021 (teacher), and symptoms didn't really go away until September, and I still have some as I said.
Did you figure it out? Something's clearly wrong with your hosting or database.
I don't think Spotify owes him anything and I don't doubt for a moment they would kick him to the curb if they were not in bed with him to the tune of a 100 million bucks. I'm sure if they did he would be fine though as I saw some tweet from some podcasting company offering him 100 million to come to them.
Maybe people who have everything at the top are afflicted with chronic boredom and playing the "game" is the only way to assuage it.
No Google, you do not own the web and are not entitled to hold it for ransom to promote your stupid gadgets.
Is he stepping down to spend more time with our families?
People buy it from Lenovo, Google is the gods they pray to so that their devices wouldn't be broken by the updates.
This is a surprisingly illustrative anecdote.

America is incredible at "doing the right thing" when push comes to shove - regardless of policy, procedure, or legalese. In so many ways, going through life in the US means people figure out how to help you, unblock you, or ignore hurdles.

Allowing Arnold to become president if he was interested is clearly such thing - no sensible person would think it should be prevented - so it won't.

But unfortunately the whole procedure is not documented, relies heavily on systemic and entrenched privilege, and as the Trump administration revealed, and how the culture has evolved since then, can absolutely be mercilessly abused and taken advantage of by bad actors. The fact that the President could violate dozens of straight up laws, and not be charged with any crime is a mockery of the justice system. It really is "rules for thee, not for me".

As a white male, I find America (and to some degree Canada, which straddles the middleground) very convenient. As opposed to when I lived in Western Europe, and found myself facing an emotionless bureaucrat telling me "I'm sorry, there's nothing I can do."

But I also know a system with unwritten rules is never going to be equal, never mind equitable.
I get very little spam in my Fastmail inbox.
> Perhaps living under a censorious regime creates such gullibility, & obliviousness to metaphor & sarcasm?

Such is life here in America...
Oh come on, he only drank a little blood, just a tiny amount.

https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to...
Talk to a lawyer, but, strategically, this is usually when you sue both parties. That forces them to deal with each other, and eventually their blaming each other ends up being argued in front of a judge.
This and Grid Garden have been around for a while and seem to come up at least once a year. Great resources no doubt, always fun! The best past threads from both ->

Froggy

https://news.ycombinator.com/item?id=10652909

Garden

https://news.ycombinator.com/item?id=18753358

https://news.ycombinator.com/item?id=14041367
Ah man I hate to hear that. It's quite annoying and I honestly don't want anyone to deal with it. Just makes waking up such a pain.

But yeah mine is mostly my arms and when I wake up. Hopefully it goes away quickly for you!
On page 7, it seems that IVANOV is the one that tells ANTHONY to short WeDeliver, but on page 31 it seems that IVANOV is mad at ANTHONY that he (IVANOV) lost money. I understand how a perceived egotistic person that IVANOV seems to be would feel this type of anger, but why would ANTHONY accept this?
History repeats itself...

https://teddit.net/pics/w:null_YecnXFugkOVw2R4-BUYbjhHM4oF7_...
After his political underdog bets 6-8 years ago got him into the white house briefly, I bet he feels emboldened to double down on this strategy.

He took those bets with asymmetric returns at the risk of complete social ostracizing in the Bay Area tech community, only to come out on top and retaining his access and control everywhere including at Facebook, all the way till now!

Thats pretty impressive, regardless of the topic or regime being discussed!

These are our role models, so don't be surprised to see more of this as others accumulate power and access.

I’ve personally found it fascinating how low the bar for access becomes when entrenched special interests leave the center all the way to far edges of the parties for causes that will never reach consensus. Its an amazing opportunity for new entrants. That’s personally how I look at the game and this has been largely successful over the last couple Congressional sessions.
Encyclopedia of Note Taking Apps
I read his book "Zero to One" and I felt like it did learn good things from it, for example that "competition is for losers". Before I thought capitalism was all about competition, but maybe I was a rube in not knowing that.
your comment reads like propaganda when you don't even mention the many problems ....

i think we shouldn't support countries with horrible human rights ? its basically legitimizing their genocide,force labour, organ harvesting from prisoners of conscience, threatening to invade Taiwan etc...

this is going to kill the Olympics, no one i know is watching it because of the issues.
yeah, the 'flex: 1' or 'align-self:stretch' types of things really are what gets the typical website column and rows type layout to work.
Be sure to do Google Checkout before you file your claim, in case they decide to deactivate your account
He’s not stupid enough to run for president, but he will certainly support any authoritarian candidate he thinks he can manipulate.
Medium is dead simple. Create an account and click the icon to write an article. Publish and share.
"When you've helped 100 little old ladies cross the road, why bother with number 101?"

"When you've done so much useful work, why would you ever want to do any more?"

"If you have so many friends, why would you ever be nice to somebody new?"

"You love your family so much, why not stop now?"

"Michael Phelps already has a gold medal, why does he keep swimming?"
Exactly. Their free speech/protest was reclassified as something illegal.
If google is trying to monopolize the hot mess by its power, then it's working, right?
That was interesting to read about.

1) Its fairly flat.
2) It is unique in that it stays consistently below 0 for extended periods.
Avoiding problems with ice, rain and so on.
3. The median age is young. (but growing consistently older)

During the summer in Oulu bikes account for 19% of travel.
During the winter it is about 9%.
During the winter in Helsinki its 7%

So they do use their bikes a lot.
And a lot more than Oslo.
But over 90% travel by car or bus in the wintertime.

Based on:

Sykkelplanlegging i tre nordiske byer
https://www.toi.no/getfile.php?mmfileid=52136
What's your favorite FM synth? :P
You also took time off training, it will take time to get back to your original form after that, could that account for any of it?

I think there is a psychological / confidence factor to running and if you're not meeting your target, it's easy to panic.

This happens to me when I run with other people, if they're faster than me, I often run slower because I panic that I can't keep up, which negatively effects my performance.
Like I just emphasized, they may not show up as statistically significant because

A) they are not pandemic, so the effect is of course much smaller

B) their impact is not necessarily primarily cardiovascular

Here's a non-exhaustive list of viruses with potentially overlooked sequelae.

Shingles (herpes zoster)

Rubella

Rotavirus

RSV

Norovirus

HPV

Hepatitis

Influenza

This is totally orthogonal to any possible defects in this study, which again I am not taking any stance on. It's merely a question of whether this study is anomalous for having been conducted in the first place. If we assume that the study is flawless, that means that COVID has long term health impacts -- fine -- but do we actually know if that's unusual for a virus?
Sacks telling (a version of?) this story: https://twitter.com/davidsacks/status/1248028580245692417
Two reasons.

First, TFA states as much: "repo program that provided nearly $20 TRILLION in cumulative loans to Wall Street".

Second, the Sep 2019 repo crisis is well-known, it lasted multiple weeks, and it was big enough that the Fed wrote a postmortem about it: https://www.federalreserve.gov/econres/notes/feds-notes/what... You can read the details, but the Fed offered very short-term loans in the range of tens of billions, rolled over for an unusually long time.
Your tool seems to understand the gist of differential cryptography better though.

You can track a 1-bit change or 3-bit change to "M" and see how it propagates through the SHA256 rounds in your tool.

----------

So your tool is probably better at understanding the underlying design of SHA2. We know that SHA2 was created well into the era of differential-analysis for example, so the designers would have inevitably done analysis similar to how your tool works.
> you're going to be immensely disappointed by every other scientific field, as well.

Not every other field. We do have scientific theories that are reliable. But the reason they are reliable is that they are nailed down by extensive testing in controlled experiments that have confirmed their predictions to many decimal places. (I am speaking, of course, of General Relativity and the Standard Model of particle physics.) So we do know what actual reliable science looks like.

The problem, of course, is that there is not a lot of other science that actually looks like that, but it still gets called "science" anyway, and treated as though it is reliable even though it's not.
So, Android ↔ iOS transfer when?
Don't their EULAs say something like "you lose the license to the product if you sue us"? I remember that such a clause used to exist in the React's licence, and I vaguely remember seeing it on some EULA I accepted recently. (I don't have the money to sue a megacorp anyway.)
First come first serve right now. Identity is based on keys generated on device and the usernames are based on a network service which I expect we will decentralize (i.e., set up your own like e-mail).
The answer is yes, every modern, developed, economy experiences the business cycle, the US is not unique in this regard.
Ask HN: Best resources to learn about engineering challenge of a marketplace
As title, I plan to build a marketplace startup 6 months down the road as an engineer lead. I would like to get a head start on learning about different engineering systems and U.S. regulations in this space. Do you recommend any books or resources on this topic?

A few unknown stuff comes to mind: merchant of record, payment system, modeling your product catalogs, reconciliation etc.
I'll take the bait.

There's certainly no industry standard for JS frameworks. It might be in your circle, but that's certainly not the case in the industry.

In my experience, I've found Vue to be a lot easier to learn and to teach to others. I can task a junior developer with a new feature in Vue, and generally speaking, the biggest changes are to simply break large components up into smaller ones. Meanwhile, I've inherited several React apps developed by shops that focus on React, and they all have weird race conditions due to 'hooks', and all sorts of code that breaks web standard.

I know a lot of people out there are very productive with React, but in my experience, the whole process is much more enjoyable when working with Vue. Neither Vue nor React are the only solutions out there, and it's important to not be too dogmatic about which tools people choose to work in.
> Which is why some are concerned about the rushed implementation of Covid vaccine mandates.

Totally understandable. Accountability is very important. Concern is .. meh. If people have concern ask the FDA & CDC & Pfizer/Moderna. Get informed. If the answer from the FDA et al. is not satisfying, ask again, reach for the usual tools, FOIA, etc. Get the data for the clinical trials, check them. Get the data from VAERS, and so on. (Just with Ivermectin there's plenty of things to look at, get to the bottom, maybe even form an explanation of the data: https://astralcodexten.substack.com/p/ivermectin-much-more-t... ... and in the end it's possible to be still not 100% convinced.)

But "oh it's rushed, I'm concerned" or "it's experimental" is about as valid as "oh my head hurts, it's because of those damn Wifi towers / windmills / transmission lines!". Countrywide health/energy/communications policy should not be made because propaganda induced mass hysteria.

See also rock music and DnD and souls of kids.

Maybe the right question to ask is "why it takes so long otherwise?".
I agree with everything you wrote. The author expected the "senior" title but the complaints in the article don't come across as experienced senior developer.

It's a shame that FAANG companies, and those that emulate FAANG hiring practices, put so much emphasis on specific languages and algorithms, since those actually have very little to do with success as a developer, or adding value to the business. I understand the gatekeeping function of those hiring practices but I think it just reinforces a monoculture and tunnel vision focus on details.

If Shopify told the author one thing then assigned something else that's a problem. One person might see an opportunity, another might interpret that as deception or poor management. I don't know what the author did about it. I would have discussed with my manager and tried to sort out the difference between my expectations (according to the job description and hiring process) and what actually happened. Some of my luckiest career breaks came from getting hired for A and ending up doing X. I even got sent to the wrong interviews once (by a FAANG company HR rep) and got a much better job than the one I was originally picked to interview for.
React has the bigger community and therefore tends to be better supported. Otherwise, the two are almost identical.
I like Jellyfin as a plex alternative. Many others exist.
I moved from using vuetify with nuxtjs to using the quasar framework because they successfully moved to vue 3 and I haven't looked back. Quasar is hugely underrated
No it can't use SMS as a transport.

It protects metadata using a mixnet and the E2E encryption for authenticated channels uses post quantum cryptography(SIDH) to establish symmetric keys. The infrastructure is run by 3rd party node runners and there's an open source API for other applications in addition to the messenger being open source.
Mostly the deal falls apart, the company seeking investment can't get it (timely) - and may have to start all over (6mo process).

Another outcome was that the folk buying in had to buy out the non-RegD parties - and crushed them on the price so those investors got a better price, the fraudulent actors didn't see the gains they thought, the company now has more % owned by new investor group than originally thought (which changes the control balance) and the founders are grumpy and distracted and mad at folk they thought were cool (and all that has a down-pressure on productivity while everyone involved gossips for a few weeks)

Edit: of you're getting your FFF round, it's all private, that group can be unqualified and you mark the deal as a Loan, so when you raise your Angel round you'll pay them back, or start the payback - and let the Angels know that's happening. Part of the investment to service debt.
> Most of these sets are sub-$50, so relatively affordable.

Second hand buckets are around $10 if you buy from a store, and way less if you get them at a flee market or from families who don't use them anymore.

Sounds hippy and extreme, but I anecdotely know around ~20 people who went that route to start or grow their collection, and that's the advice I'd give people if asked. Lego seems to be the only toy people don't mind just getting second hand, machine wash in a net and start playing.

Bucket will stay in store as the anchoring price, and also to avoid having non Lego brand take that shell space, but I don't remember seing any marketing effort from Lego to push them in the last 10 or 20 years.
https://getsession.org/ Already does all of these.
Curious question to any googlers on here, do engineers ever refuse to push code change which disables a feature like this?, do you get to push back on changes and ask anybody asking for this to get approval from higher up or in-general create bureaucracy/resistance against user hostile changes?
Same issue here.

From my googling it just seems like a display to show the weather, calendar, what music you’re playing, etc. [1]

[1]: https://www.lenovo.com/us/en/smart-display/
Why pluralsight specifically?
Yes, it is perverse how intolerant devs tend to be toward old systems that perform valuable service and make a lot of money. There are some interesting ideas in those older systems designed to run with incredibly small resource constraints. That said, I think it's also true that incentives aren't always aligned when it comes time to port away from the entrenched environment, as these projects, if successful, constitute a real loss of income for the older devs.
The benefit of a market economy is that if people really do consider something critical, they will pay more for it.

The increase profit margins will attract competitive companies or existing companies will be forced to pay workers more for overtime to satisfy the demand.

The negative of this is that the poor or unemployed have very few dollars with which to vote. A UBI solves this by giving them at least some small percentage of the vote.
What are the diversity requirements for a single position like this? Do we need to start a breeding program to get somebody with just the right percentages?
That sounds like something unenforceable if there ever was an unenforceable clause.
Ask HN: Where are the “docs” for mathematical notation?
I am looking for a standard that describes the precise definition for mathematical symbols and notation.

Is there a widely accepted, precise standard for this like there is standard for the C language?

Obviously, I am no mathematician :-)
Wow, I installed the tiling extension and it's much more pleasant than vanilla kwin.

I first used KDE over 20 years ago, version 2.x. KDE 4 was awful, and I moved to Gnome. Since version 5 I'm back on KDE and most notably, the battery life of my laptop is twice as much! And it's configurable. And beautiful.
>The 2 who were found to have made unethical trades were removed.

Even the two that resigned over this were exonerated because the entity that approves the trades stated that they were done according to the rules in place at the time. They stepped down in an effort improve the image of the Fed and to quell the outrage brewing at the time.
Wow. No one on the left does that?
If your personal vandetta is strong enough, you could represent yourself and only pay a few hundred in filing and court fees. It's fairly common to do that in small claims court so the judges are used to shmucks. And I would be shocked if Google/Lenovo spent money on lawyers for a case this cheap, they'd probably lead with a settlement offer for $2k or whatever.
Buffett's "good businesses have moats" is roughly equivalent.
I am not in your case, but after years of crashed cardiovascular capacity, 6 months of regular bike plus a bit of upper body workout finally brought back some sense of normalcy in my breathing. Just the sense of having some room for air inside your chest. Anyway I hope you can find a rehab plan to help you get back up. And support and patience.

ps: cardio and lung go together, so don't forget to let your heart rise up to ensure good blood flow and blood pressure, it will help your lungs too. Taichi or yoga like poses (and walking) are wonder to bootstrap blood flow in weak health.

tc
You forgot Stripe.
Interestingly enough, as of 2016ish you technically can invest - but only in companies with active Reg CF (https://www.sec.gov/smallbusiness/exemptofferings/regcrowdfu...) offerings. Think sites like StartEngine and Wefunder.

Of course, Reg CF has a host of its own challenges for founders (which I can attest to firsthand..). Also most accredited investors aren't necessarily onboard with it (they prefer private financing where they get more say in the terms). Still, it's a step in the right direction because it gives normal people the opportunity to invest, while also requiring companies to provide actual due diligence documents and comply with SEC laws before accepting money.
Small communities where you can shop for a community that aligns with your desire to speak freely, and where non-free communities have alternatives.
That's a valid approach but I am not sure soon there will be much non-smart device offerings possible to choose and purchase.
Ok, it should work more reliably now.
Police use Israel's NSO to target politicians, businessmen, journalists
If you're choosing between those two, then I find Vue still better at this than react, where you have to go full JS rendering. Vue 2 had inline-template support which allowed progressive enchantment of HTML. Vue 3 however dropped support for that (there are few workarounds).

All in all both frameworks aren't too great at sprinkling dynamic functionality on server-side rendered HTML.
I will never, ever, subscribe to an app.

If you make an app that somehow creates a time portal transporting Jennifer Love Hewitt circa Party of Five to my house with amorous intent, I will turn up my nose and refuse to subscribe.

On the other hand if you _sell_ that app for a reasonable price, I will happily purchase a license. And then you can release a new one yearly with new features, perhaps teleporting Alyson Hannigan circa Buffy the Vampire Slayer to my love casa, and I'll buy that one too.
/r/cade will quickly show you a lot of permutations and combinations from the builders themselves. Some of what these guys have done is mind-blowing.