skysight-inc/HackerNews huggingface dataset:
> There were plenty of knowledgeable people saying all along that sterilizing nutralizing immunity in the mucosa was unlikely to be achievable for a vaccine against a respiratory virus that most commonly had no viremic phase, particularly as a shot given in the arm.

You are absolutely right, this has been my experience too. Pointing out what you did about (lack of) sterilising and (importance of) mucosal immunity usually got you downvoted here up until recently. It doesn't matter what your political persuasion is (I am, or at least I was, going into the pandemic, a left liberal), the idea that the vaccines would end the pandemic if only enough people got 1, 2, 3 or more doses was gaslighting from the beginning, probably arising from flippant remarks from politicians when asked for target dates to lift lockdown restrictions - "when X% are vaccinated!". And the idea that this was never what was being said about them this time last year is also gaslighting that's happening right now.

The problem is that this is a very nuanced subject. Everyone thinks they know what's going on, because they've been told it's simple: get vaccinated/boosted, work from home and do as we say and this will all be over. Much of the data being used to justify this was one or more of badly collected, badly analysed or badly interpreted by dishonest politicians, journalists, scientists and members of the public pushing their own (or their bosses') agendas. Instead of opponents' arguments being heard and countered in public ("sunlight is the best disinfectant"), they have been deplatformed under the auspices of "public safety". Scientists have lost their jobs for saying something to counter the narrative - it has become illegal to disagree with the scientists the politicians listen to, under punishment of losing your livelihood. It has been a total shitshow that has exposed how corrupt the whole system is. It has made me quite depressed at how little we've apparently learned since the last century. I thought we were living in the age of science, but what we have right now is far, far from it; maybe we should call it the age of misinformation - driven by humans' psychological maladaptation to their own incredible invention, the internet.
European oil facilities hit by cyber-attacks
>To be fair, everyone knew that Amazon's "Other" category was almost entirely advertising in previous reports.

This is true.
It's inevitable that at some point in the future the only way to achieve true privacy will be to be completely and totally uninteresting.
The internet is much better than a library. I've gone to the library a handful of times and the information there typically pales in component to the information that can be found on the internet. The internet also has videos too which can help explain concepts. Books in a library are typically old too. Good luck finding a book about some new piece of software that came out.
Are they better for pedestrians, cyclists, bikers and other drivers, though? I imagine it's much easier to see things in front of you with the cabover design.

Personally I'd optimize a bit more for everyone else's safety, since you know, there's more of them. Plus a semi is a multi-ton missile going 90kmph.
GoFundMe is a very left leaning organization. They have shut down numerous right leaning GoFundMe pages. This shouldn't come as a surprise.
Peerspace (https://peerspace.com) | Software Engineer, Full-stack (JavaScript, Clojurescript/Clojure) | Full-time | REMOTE (US)

Peerspace is on a mission to bring people together. Our marketplace uncovers the world's most unique spaces — such as lofts, rooftops, and photo studios — and opens them for people to book almost any activity. With Peerspace, guests have hosted weddings, photo shoots, team meetings, and more. In total, over 5 million people have attended a Peerspace booking, and we're looking for people who want to help us reach the next 50 million.

The Role:

We are looking for a software engineer with 3 or more years of experience in full stack development. This engineer will join the business engineering team and collaborate in the architecting, design and implementation of internal facing features and services.

This role requires familiarity with technologies that are common on both the front-end and back-end, including operational aspects, scalability, databases, caches, search engines, etcetera. As a member of the Business Engineering team you’ll find yourself working on many aspects of the business with a specific focus on developing for and scaling our internal teams in addition to automating existing manual processes.

Responsibilities:

● Help maintain and add features to the administrative website used to operate the Peerspace marketplace (Clojurescript/Fulcro)

● Add features to existing backend services and create new services (Clojure and Node.js)

● Collaborate with the Product and Engineering teams to complete projects and solve problems

● Implement 3rd party integrations for things like fraud prevention and risk analysis

Qualifications:

● Minimum 3 years of work experience

● Experience with JavaScript, Clojure, or Clojurescript

● Working with a modern front-end framework like Fulcro, React or Angular

● Experience with API design and micro services

● Ability to work across the stack

● Likes problem solving

● Can think in the short, mid and long terms

● Willingness to use and learn new technologies

Direct Link: https://jobs.lever.co/peerspace/50a749e9-eaef-4ac9-8209-0a78...
otoh I looked up a few games my kids play that I consider to be flagrantly evil (genshin, gardenscapes, emojiblitz) and they all score a "neutral" here
okay so this is an unlawful protest that has a detrimental impact on residents, the environment, and local business. Can someone explain to me why this is tolerated and why these people are not simply being arrested?

What it reminds me of is that 2014 standoff with the Bundy family on federal land in the US or farmers in France. Some groups can just do whatever they want apparently.
Incorrect.

Smallpox has been around for thousands of years, and it has not evolved to be less virulent.
An interesting idea for a sci fi novel.
More transmissible (specifically fitter) but not necessarily, or even usually, less virulent. That is just an urban myth sadly.

Endemic just means 'regularly found', it does not mean mostly harmless!

Vaccine escape refers to a virus evolving to avoid vaccine induced immunity - and can happen with infection induced immunity too. As it happens T cell immunity against severe disease has been holding up just fine - and has saved countless lives. If vaccine uptake was universal, and we took a few sensible precautions, a virus can be completely suppressed, like measles, so wouldn't have a chance for escape mutations.

Your per capita statement is plain wrong.

Now you've been taught a few things about viruses, you can stop spreading misinformation!
I also did. Another ridiculous thing was that the article initially claimed no fossil fuels, but the one thing they couldn't live without was wood-burning fireplaces. I mean don't they both generate large amounts of carbon dioxide?
The problem we've had where I live, is that when people do a good job reducing water/electricity consumption the utility companies have to either jack up their rates, do layoffs, or go broke because they aren't able to amortize their fixed costs as well.
I don't think this is true, if it shifts usage from spot instances to the reseller's spot instances backed by AWS reserved instances they'll be making less money.
Calling Covid a "novel" virus was a mistake

It was called a novel virus to indicate that no person already had (acquired) immunity against it. What inference you make from the word "novel" is on you, not on the rest of the world.
> Not really true. They do to be better among their peers, doesn't matter if there are PC players out there, irrelevant.

If you really wanted to be a player without autoaim / bullet magnetism / all the stuff Halo "aimbots" into your controller, you'd be playing Counterstrike.

But no, people play Halo. Because people like (subtle) aimbots making their headshots more consistent. Games like Halo (and other FPS games that came after Halo, such as Battlefront or Call of Duty) all take this auto-aim concept to varying degrees.

Its now a staple of modern FPS games.

------

But yes, I recall the "mouse practice" people would do to get better aim on Counterstrike. Those headshots don't happen by themselves: there's a lot of "move the mouse" practice in Microsoft-paint (practice moving one pixel at a time or whatever), and learning the positions of your wrist.

Most people don't care about that level of dedication or practice. I think it suffices to say that typical FPS gamers today prefer the subtle aimbot to handle that level of muscle memory.

I'm being a bit hyperbolic. Obviously the "Counterstrike" players and community cares about this stuff. That's why they still play Counterstrike. But I also am ready to admit that their community is a small minority of players in the greater FPS genre.

-------

"360 No Scope" happens to take advantage of this bullet magnetism / autoaim as well. Moving the reticle quickly IIRC engages the auto-aim bot a bit more.

> It's the reason why sweep shooting works so well. Sweep your crosshairs across the screen, pull the trigger when it crosses something, it'll hold onto them slightly as it goes by.

The game's "auto-aim" system effectively fires two bullets for each frame. If your target is "between" the two bullets, then it counts as a hit.

Sweep-shooting is moving the crosshairs really fast, so that these two "bullets" are spaced as far apart as possible. So you've grown the auto-aim area.
fun stuff... use cases?

here is a couple...

1. profile location switching. pin 1 on/off = work/away - switch system configs appropriately.
2. desktop workspaces, flipping pin 2 on enables workspace switching. pin 3 and 4 control workspace number.

What else?
Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater
Metaplanetary was published in 2001? "Computational dust motes" features in "A Deepness in the sky" by Vernor Vinge which was published in 1999 so Tony Daniel didn't invent the concept. I wouldn't be surprised if the concept is even older tbh.
> Cab-overs have no other advantages, and everything else the article talks about is a side-effect of the length limit.

There are definitely other advantages, such as that cabovers can generally navigate into tighter spots because of it's tighter turning radius. Yard space is usually very limited and roads more narrow and windy than America, so this is definitely a benefit.

I've seen some crazy tight turns on some unreasonably tiny country roads here in the UK that I can't imagine could be done with a vehicle 2 meters longer.
The change in cash flow especially cash flow less leases leads me to believe they are massively expanding either data centers, warehouses, or both. New aws regions? New amazon country launches? Or more if each in their existing locales? Either way, those are some hefty new investments they put cash down for.
Thanks for sharing. Interested to learn more regarding your thoughts on "scarcity mindset around money". If you have written anything on the topic, please share.
> I think we have to divide roles that requires deep work from roles that don't.

Very similar is the background mind vs not roles. Some people are great at completely separating their professional knowledge work time from the rest of their life. I am not. If a company pays for me to write software, they’re also getting my time in the bath tub thinking about software. This is different from when I was parking cars as a valet.

I would never, ever take a “reduced hours” software job for this reason. A job that had 25 hours on the books would occupy a similar amount of my headspace to a normal full time job but probably expect to pay less.

For how many employees seem to want it and what a deal it is under the right circumstances, I’m a little surprised more companies don’t offer reduced hours schedules for software. Maybe some adverse selection component.
HLS to Safari/iOS and Dash to everything else.
No that's simply wrong. Antibodies are relatively unimportant and levels decline quickly. What actually matters far more is cellular immunity. Fortunately the vaccines and recovery from infection have both been shown to produce a significant level of durable cellular immunity in the vast majority of patients.

Who do you personally know in the linked podcast? What are your medical qualifications?

https://peterattiamd.com/covid-part2/
Creating Error Chart in JavaScript: Covid-19 Threat Perceptions in U.S. by Party
A couple possible reasons:

1. To profit they'd have to slow down investments in improvements to logistics, and they didn't. It doesn't seem like the year to do it?
2. Increased labor costs.

You can't figure this stuff out from first principles; you have to look at what they're doing.
Would like to hear if anyone finds it useful or general feedback. Thanks!
I had thought about this as well, but even prebaking an image, lets say deploying desktop machines... you still have the issue of needing to validate configuration changes once a machine is deployed.
Similar experience here. I also found that Wal-Mart has a similar selection (lower prices for some items) to Amazon. It shares the same price threshold for free shipping, and also arrives sooner (reliably two to three days from Wal-Mart in my area, versus five to seven from Amazon without Prime).
Netflix disables HDMI out on it's Android and iOS apps with downloaded content, this won't work.
In my experience, all new accounts that try to post in main subreddits will be shadowbanned until a certain level of karma is accrued.
Turning inefficient corporate spending into rockets is a really interesting phenomenon in our system :)
Won't insulating the pipes reduce the heating effectiveness?
I like the tennis streams on prime video, but they didn't show any of the Australian open. That made me consider cancelling prime...

The faster delivery is a nice bonus, but I have prime for the live tennis content mainly.
Since people are downvoting the parent, check out https://advisorsmith.com/data/most-dangerous-jobs/

Near as I can tell, there are good statistics available from the BLS about fatal on-job accidents, but not so good for definitions of "dangerous" that also include non-fatal injuries.

If we're talking pure fatalities, policing is dangerous (it's on that list), but it's much less dangerous than a bunch of other professions... such that you're about 2.3x more likely to die on-job as a delivery driver than as a police officer.
> This in turn decreases the relative purchasing power of a dollar.

you're again conflating price and monetary inflation. and again mixing in somebody else's prejoratives to flavor your discussion of their topics.

here's a link [1]

[1] https://mises.org/library/inflation
Great article. thank you.

It seems following up with CD22 is a useful practice:

"Another Single-Targeted CAR T-Cell
Loss of CD19 is a common mechanism of relapse after treatment with CD19-targeted CAR T-cells. Similar to CD19, CD22 is also diffusely expressed in B cells in patients with B-ALL (92–96), and CD22 expression can be detected in a number of patients with CD19-negative relapses (14). Single-targeted CD22 CAR T-cell therapy is also a common therapeutic tactic for CD19-negative relapse. A phase I dose-escalation trial of a novel CD22-CAR with a 4-1BB domain was conducted (97), which enrolled 21 children and adults with R/R B-ALL, involving 17 children who did not receive CD19-directed immunotherapy. A CR rate of 73% was observed in patients receiving CD22-CAR T-cells, involving 5 patients with dim or without expression of CD19 in leukemia cells."

Although I am confused because the next section, while touting the benefits of CD19/CD22 cocktail doesn't present much better statistics:

"Sequential Infusion of Two Groups of Single-Targeted CAR T-Cells
Clinical studies (98) have shown that sequential infusion of third-generation CD19 and CD22 CAR T-cells, which is called cocktail therapy, is feasible and safe for patients with R/R B-ALL (Figure 4A). In a clinical trial, cocktail therapy was used to treat 27 patients with R/R B-ALL. As a consequence, the trial yielded a 6-month OS rate of 79% and an event-free survival rate of 72% with sustained remission, in which 24/27 (88.9%) patients received CR or CRi, and 13/27 (48.1%) patients attained MRD-negative CR. The center subsequently enrolled more candidates (99), among whom 81 patients received CAR22 T-cells following the infusion of CD19 CARs, while 8 patients received CD19 CARs following the infusion of CD22 CARs. The median follow-up time was 7.6 months. Among 50 evaluable patients, 48 (96.0%) achieved CR/CRi by day 30, 94% of whom were MRD-negative. The PFS of B-ALL patients was 12.0 months, and the median OS was not reached. In total, 23 patients experienced a relapse, with no CD19 or CD22 antigen loss observed. Drawing on the finding that a high MRD-negative rate in R/R ALL patients was achieved by sequential infusion of third-generation CD22 and CD19 CAR T-cells, demonstrating this method has great feasibility for the treatment of CD19-negative relapse ALL."
It was just common sense. Flu vaccines have never been much more than 50% effective. The idea that you can just vaccinate against such a hugely virulent virus like COVID, and expect it to stop spreading with such ineffectual vaccines just made no mathematical sense what so ever.

If people didn't understand that it is because they didn't want to.
You're pulling that out of thin air. You have no idea if that is true. Your logic also says a seven day work week is ideal. But obviously we need to rest. Does 2 or 3 days of rest make us more productive? I honestly don't know. And neither do you.
But not nearly as good as being able to buy it (assuming the single-family, multi-year home that the author is describing). Communities need both options, but the current climate leans far too heavily toward renting in situations when buying would be better for everyone.
> I do miss the amazon of 10 years ago though.

Why? What about it do you miss?
Prime memberships are not included in their AWS figures. So any revenue generated there within is only helping offset some of the retail losses.
You used to be able to for HD, you've never been able to for UHD.
In addition to other listed benefits, some Amazon shows are pretty decent too. LOTR will be pretty massive.
For a second I thought they might provide a product for all the people recently kicked off the formerly "Google Apps" Gmail.

Sad to see this is the exact opposite.
3blue1brown has a great series of videos about how you should reason about these types of ratings.

https://www.youtube.com/watch?v=8idr1WZ1A7Q
The problem is that '10 years old' in computing is fairly ancient, whereas in hi-fi, quality hardware will keep going for many decades with minimal maintenance.

Not sure why they felt the need to split the app into two rather than support the control of all devices through a single app, even if the S1 devices have a bit less functionality, or if S1 and S2 devices can't be grouped into a single zone.

And then they've prevented some new devices from running with the S1 app. My parents tried to buy an extra speaker, but it didn't work with their S1 system (whereas only a few months ago, they added a soundbar that worked fine)

It's a mess. It could have been handled a lot better. What new features do you even get with S2 that require more powerful hardware?
From slavery to socialism, new legislation restricts what teachers can discuss
Browser Shell: A Linux VM in the browser serving a website
Sure, but equally there are plenty of smarter-than-me people who think it's all a giant scam, so I'm inclined to trust my instincts. After all, just because they're smarter than me doesn't mean they aren't trying to scam me or haven't got caught up in some bullshit fantasy.

Besides, if the technology is actually valuable in some way I cannot yet perceive but that will become obvious over time, then I can just wait until it becomes ubiquitous and reap the benefits without risking anything.
Meta stock plummets after weak earnings report
What do you mean "up for renewal"? You can cancel Prime at any time, there's no contract term.

(Personally I keep Prime mostly for Prime Video, and a few other perks. I typically only buy a few things from Amazon each month, so the free fast shipping is a bonus for me, not a must-have).
>Prime's price is going up.

and it is seen as sticky enough to not lose tons of subscribers.
Yes, small purchases through Amazon (enabled by Prime due to no price minimum for 'free' shipping). I picked up a tip on Hacker News to avoid small ~$20 USD purchases because it adds up, and this habit has saved me a lot of money.
As well as the other responses, it is very common to lease your fleet in Europe, particularly for 3PL's who will lease the fleet over the duration of their contracts.

Most transport is done by 3PL's who will lease the trucks and hire the drivers.
Have cancelled mine a few years back as I realized the only thing I was using is 2-day shipping but I have been just ordering multiple items which exceed $25 to leverage FREE shipping and usually they ship fast. So no need for Prime for me!
Is there a difference with manufactured vs prefab in the resale process in the eyes of lenders?

That's what has always steered me clear of doing this. If you need to sell, I've learned that manufactured homes are not lendable by many institutions. Maybe this new class of modular will count as "Stick built" for lending purposes. They seem really nice.
agree, it’s almost better they didn’t suddenly turn a massive profit, next cycle they’d be in the mess peloton is in.
> I would also imagine it would challenge the ideas of religious people around the world.

It seems to me that simulationism and theism are mostly compatible beliefs, perhaps differing only in the nature of the creator. If anything, evidence of simulation seems like it would come as a greater shock to atheists and the irreligious.

> Let's hope its not a simulation.

Why not?
Only 22 orders placed in 2021, and a spot check of ~15 of the items would ship "free" anyways. I don't care enough to check every single item, but of the ones I checked I could not find a single one that would have an added shipping cost.

The "2 day guarantee" doesn't really exist anymore, so I have to ask - what am I paying for?
>It's at least possible we could do the same here if we didn't have such a high level of resistance to getting vaccinated.

why hasn't the flu been eradicated then?

>It was only after (in the US) vaccination rates levelled off and Delta came along that I began hearing people talk about COVID as endemic.

that's because most people have no idea what's going on. experts were saying this was the likely outcome from the begining
Forward looking guidance is made by the company for the next quarter in the current quarter. Missing guidance means that company which lot of visibility into its sales and operations had unanticipated changes to its operations and that is generally bad.

Analysts estimates are made by Wall Street predicting performance of the company without insider info (in theory), top analysts generally get access to companies they cover while company management are not supposed to disclose any material non public information in such meetings, even when following the law to letter lot of indirect information would become available, Matt Levine has written often on Regulation FD [1] . The point is estimates have some basis in fact and information as well.

[1] https://www.bloomberg.com/opinion/articles/2021-03-09/sec-go...
It's easy enough to get free shipping without Prime (just wait until there are enough items in the cart to get free shipping). But I'm still getting value out of Prime streaming so I'm keeping Prime until that changes.
You can see a correlation between healthy and unhealthy games in their icons.

Ungealthy games are mostly high quality 'renders' for lack of a better term. The healthy games have a much less attention grabbing 'lower quality' icon.