skysight-inc/HackerNews huggingface dataset:
Dr. Friedman and team at UPenn are working on exactly this. An mRNA based prophylactic (and also potentially therapeutic) vaccine for HSV. I think they were originally using some other form of vaccine (a protein vaccine?), but then realized that mRNA was a lot better. He has posted a few video updates on the progress, and it looks good, but of course it hasn't entered phase 1 yet (supposed to start this year).
Yes. Bungie was an independent studio back in the 90's, then MS acquired them for Halo. Bungie split from MS in 2007; the Halo IP remained behind under 343.

They were under Activision during the Destiny era until 2019. So if they stayed, they would've ended up back at MS. The M&A merry-go-round continues.
I believe this is a naive comment, and I have a reason to point it out. That is, what is "illegal" and not is not as bright a line as many people are taught. A deep examination of gambling systems, all of the parts, will show that this legal-vs-illegal belief on the part of the gambler, is core to maintaining order over time. Yet, game operators and their allies, know very well, and in real life can, manipulate the odds of the outcomes of the process. (edit clarify) Once a neutral observer, say people here, actually learn that part, further inquiry can show that the predation of others for profit, the physical control of common spaces, and control of life-and-death level inputs, such as weapons and their use, are also known to, and are used, by the operators. There are dozens of corollaries to this game analysis. I hope that the reader of these words, will understand them.
One of Tesla biggest mistakes was not to make that charger an open standard. It might have been an industry standard if they had.
Create a site in Rails that can perform some basic functionality, or a simple API in Grape if you want something lower level.

Personally, I would make use of something simple and interesting like the Discogs API for my project to interact with and create something like a music genre browser or application to connect artists who have worked together:

https://www.discogs.com/developers/
Where it can get that cold, are outlets near parking spots common for block heaters?
are there good system-wide adblockers for ios?
I hate the whole mobile experience, tbh so I didn't invest much time into it and just don't use it.
I can only see this as some weird way to respond to Microsoft's purchase of Activision although they must have been in discussion in advance of that.

This is the meme:

"Mom can we get an Activision"

"You have an Activision at home!"

Activision at home is destiny
You can add remote start to a basic vehicle as an aftermarket upgrade.
You realized that most of the vitamins we get from a meat-based diet are in the food because we feed the multivitamins to the animals? It is just an unnecessary layer of indirection added.

It turns out that people who earn a living with producing meat are just a lot better to making sure their livestock gets everything they need (nutrition wise) than people who just eat stuff when they are hungry. If some professionals would create proper vegan diets and force feed it to us you can be sure there would be no deficits.
Wasn't Bungie Microsoft's first real gaming acquisition?

https://www.ign.com/articles/2000/06/20/microsoft-acquires-b...

Almost 22 years ago.
I think the WWI experience soured the British political class on the gold standard: wild inflation during the war, followed by serious deflation when it was time to rebuild. The swing is impressive in that buying power chart.

Also, I'm sure the average British voter likes what has been achieved in the past hundred years and prefers inflation to having no money in a rigid class society.
> Can you give an example?

It's in Romanian, because this is the league I follow, but something like this [1], maybe Google Translate can help, basically a player (incidentally, playing for the team I follow) letting in a goal just because (the goal on YT in here [2]). Maybe that was still because of a genuine mistake, but searching for "pariuri site:https://liga2.prosport.ro/" returns many other articles related to suspected betting in the Romanian second league.

Also, at a (much) higher level club owners like Napoli's De Laurentiis might be crazy enough (I do personally see him capable of that) to be directly involved in this sort of stuff.

There was a very suspect thing happening at the end of last season in Italy, basically Napoli needed a (relatively easy) home win in the last stage against a smaller opponent which had nothing to gain anymore, but they didn't, the match ended 1-1 [3], so Juventus (one of Napoli's biggest rivals) got their CL place instead. As a Juventus fan I saw that as very, very suspicious, especially as I could have sort of guessed beforehand that that sort of thing would happen.

And before anyones says: "no Serie A club owner would do such a highly illegal thing!" a couple of months ago Sampdoria's (now former) club owner got arrested because of some other illegal shenanigans (afaik not betting-related)

[1] https://liga2.prosport.ro/cupa-romaniei/se-va-sesiza-comisia...

[2] https://youtu.be/Gl4gkgL25wE?t=237

[3] https://www.espn.com/soccer/report/_/gameId/582783
I’d like to see these kind of second brain tools mergable with a global anonymized database. Where my notes merge with the collective, and I can traverse ideas that spawn from my database into the collective whole.
> This is because there generally isn't a known mechanism for vaccines to have long term effects.

I know a lot of people believe this, but as a developer who regularly deploys code to production, this mindset blows me away.

I'm not saying that being a developer means I know anything about this. I'm well aware of my (our? I don't know what you do) peoples habit of thinking being good at our craft means we're also somehow suddenly good at others.

But if I told someone that I don't need to know the effects of v7.1.3 before patching it because I can't think of a mechanism for it going wrong, and besides, we already released all those other versions and they were fine, I'd hopefully be fired.

I get it, software and medicine are different things, and some things just aren't practical in meat space, but the mindset around testing is something that I think will always be difficult for me to understand after being in this occupation for so long.
Also, isn't Vanced closed-source?

I find the people behind it slightly sketchy.
If Linden launched now instead of 20 years ago, they'd have tons of funding and almost certainly be a unicorn.

Compare

https://www.crunchbase.com/organization/secondlife

https://www.crunchbase.com/organization/vrchat

They were well ahead of their time. Or even if they weren't, the market simply wasn't ready for them.

As an aside, I have a few anecdotes about Second Life:

- I remember IBM paying money for virtual real estate in second life. They set up a marketing presence, too. It seemed like such an IBM thing to do.

- My university was giving class credit to a grad student for building a virtual mock up of our campus in Second Life. It was a thesis project, I think. I remember thinking he was rather late to the game, as Second Life had already dropped in popularity versus MMOs such as WoW.

I wonder what those events would have been like today, with VRChat and the emergence of the "metaverse". Everything old is new again.
Hey, post author and Nolific creator here. Nolific is very, very new, so I don’t think there will be a lot of other users, yet. For me there are a couple advantages. The main one is that it’s in the browser, where I spend a lot of my day, which makes it friction free. I mention a couple more in the post. I’m also super excited to add “actions” to Nolific. When I do, it will pass any text you’re working on to any API end-point. I’ll use it for things like, “Post to my blog”.
I mean, would you say the "we've lost the drug war" falls into that rhetorical technique? Is that just saying "everyone has to adapt so the pot industry can make money?"

Or "pandemics are inevitable, we can't contain them, so everyone has to adapt so the pharma industry can make money?"

Seems like calling out that form as a "rhetorical technique" is not useful in determining the quality of the argument.
You are right. A heap/priority queue would be good. However the resources needs to be iterated and ticked every frame - to update the rendering data (transform) and perform culling (because the viewport might change - a player might move or zoom the camera).
> The traditional vaccines don't work any better.

Didn’t say they were. Rather that mRNA don’t seem to be approved faster for the new variants.

> This is evidence MRNA is better than traditional vaccines.

Haven’t been following the field that closely. I only seen one pre-print(probably Hungary?) where Sputnik was on par. Would love to see data if you’re willing to share.

Edit: I admit I’m a bit confused since I mixed “traditional vaccines” and Sputnik/AZ together. The latter aren’t traditional since adenovirus-based vaccines haven’t been previously deployed, same as mRNA vaccines.
It's a lot easier to get folks to agree to one or two shots one time than to convince them to change their sexual practices, one would imagine.
I just use wikilinks and markdown, edit it in VSC; it is helpful if you schedule yourself like a hour of study time for some topic which forces you to revisit the stuff you wrote previously, regularly. I'm going over some math / stat / probability at evenings for 1-3 hours and the wikilinking is definitely helping to learn the stuff.

But on topics where I am not doing revisits regularly even if to just to light a bulb in my head ("Oh that topic, yeah I remember it"), I don't see much benefit accumulating.
Rare did go down after acquisition, but what others are you talking about? Their biggest (Zenimax) one will start releasing new Xbox and PC exclusive games from this year onwards, so it's still early to call that one a failure.

Mojang, is doing Mojang thing i.e. Minecraft and while they haven't had a great success after that, they're still doing fine.

Playground games is doing Forza which is actually pretty popular among racing players (perhaps the most popular).

Obsidian haven't started to make Xbox and PC exclusives yet, but they'll also start with that presumably next year.

I don't know where you're getting "Most of Microsoft's acquisitions in recent years have been failures." this.

On the other hand, Sony's way of buying studios is way different. Most of the times, they have already worked with those studios in past to make a PS exclusive and then they buy them. I agree that Insomniac is doing great (better than any of Microsoft's purchases), but other than that, there isn't much just like MS.

I think we will get a better picture of whose acquisitions work best after 5-6 more years.
I love ACC in my 2020 accord (which is the same generation as your 2019). I've never had it hit the brakes hard enough to be jolting, even when a car changes into my lane.

The LKAS is hit and miss, like you said, unless the lines are very clearly visible, it can't stay in the lane. I wish it looked at the car ahead to help with lanekeeping. But it's never surprising when it loses sight of the lane markers (though it does tend to drift to the right at exits, but it doesn't make a sharp move). But even in its current state, LKAS is great for long freeway drives.
If your martial status is documented as being considered in the thought process leading to firing (I know now, they quit in this case), then it can show that the hiring process was discriminating. It's a possible court case, although the outcome would be anyone's guess (if they they don't settle).
What We Can Learn from How the 1918 Pandemic Ended
So much of this sounds like a dystopian nightmare.

> Meta’s employees have been asked to contribute to the change in other ways. In November, they were asked to sign up for Project Aria, an effort to test some new augmented reality glasses ... Employees could “earn points and win swag” by wearing the glasses and gathering data through the device’s cameras and sensors, the memo said. To reduce people’s privacy concerns about being filmed with the glasses, employees were asked to wear a T-shirt identifying themselves as a “research participant” and were told not to view or listen to the raw data captured by the glasses, according to the memo.

> Adam Draper, a managing director of Boost VC, a venture capital firm that invests in companies focused on “sci-fi technology,” said Meta’s new bet was well-timed. “There will be entire economies and countries built digitally through VR/Web3, and we are just scratching the surface,” he said, using terms to describe next-generation technologies for building the metaverse. He noted that Meta was in the lead with virtual reality because of products like its Oculus headsets, adding, “This is the sci-fi future, and Meta made the bold move to make it a reality.”
just hire new people every year so you always have exactly who you want
I still remember when Bungie was one of the only companies that made games for Macs. The Marathon trilogy was a memorable part of my childhood.

Then Microsoft bought them for Halo, and spun them back out (sans Halo). Halo was first demoed by Steve Jobs - it was going to be a Mac game.
For text-heavy websites (blogs, news), I use archive.is as a "wget" [0], as it were. It is unreasonably affective at rendering most javascript-driven pages too (like twitter.com).

[0] https://news.ycombinator.com/item?id=3083536
I have an interest in this too, with most of the worlds population infected with some type HSV and being linked to Alzheimer's disease, MS and many horrible disease.

It's about time we defeat HSV too!
I’m getting re-asked cookie preferences every time I go to sites like SO. Is it OK for sites to ask for cookie preferences on return visits to their sites after preferences have been set and “saved”? Or maybe I’ve turned off the Cookie that would have saved preferences…
Nebula seems to split profit 50/50[0] while YouTube splits it 55/45 to the channel[1], and Youtube Premium views are regarded as being sometimes 10-20x the payout of an ad-supported view[2].

0: https://nebula.app/faq#:~:text=How%20do%20the%20creators%20g...

1: https://variety.com/2021/digital/news/youtube-partner-progra....

2: https://twitter.com/LinusTech/status/1486935690315112455?s=2... and https://www.dailydot.com/upstream/totalbiscuit-youtube-red-p...
Not sure what the issue is. Tens of thousands of people get HIV each year; all you need to do is give some of them the vaccine and see if those people get HIV as much as the people you didn't give the vaccine to.

People are already getting infected, we don't need to do anything for that to continue to happen.
They've explicitly stated that none of their games are going to be exclusive. FAQ here: https://www.bungie.net/en/Explore/Detail/News/50989

(I play a lot of Destiny)
I'd suggest you prioritise defining a format earlier rather than later. The format / standard can evolve over time to accommodate the evolution of your product (that backwards-compatible evolution can be defined as part of the first version) but to go from no standard to any standard is much more difficult once people are already using the platform: you'll either break established workflows, or burden yourself with a lifetime of supporting unbounded backwards compatibility (because every client will, by virtue of writing integration code, unintentionally define their own standard).
Love the author, hate the wait. More than 6 months till I can read the book feels like this is more teaser than I want. Not enough to sour me on pre-purchase, but definitely enough to grumble a little about it here on HN…
If we get down to brass tacks, this is a situation where sex takes precedence over gender. The HIV epidemic in the West was borne by XY people, and the history of HIV in America is by and large an XY history. What are we obfuscating by painting this history with a broadly "queer" brush?
I use Obsidian to take notes. I like it. I keep a daily journal there and connect it out to notes I open on different projects I work on or books I read.

When I started using it I thought about it like a "Second brain" in the sense of it would somehow make me effectively smarter. I imagined referring back to stuff I'd written, building connections, and the notes letting me discover or recall insights I may have missed. Instead, like the author of this piece, I find that most of the benefits seem to come from inspiration and overcoming inertia and I almost never refer back to things I've written in the past.

The inspiration is usually simple stuff, like if someone told you a problem you might immediately react with a solution or question. Same kind of thing happens when you write out problems. For example, recently my wife was annoyed at me because I haven't done a chore I said I would. As I'm just jotting this down into my daily journal I have the obvious "Why don't you take out the boxes now?" question. I answer that now I don't want to do it because she scolded me and I don't want to reinforce her scolding me. As soon as I see those words, I realize that's childish and I go take out the boxes.

It's a realization I might not have confronted had I just existed in a non-reflective state. By typing out what's going I gave myself the chance to make conscious questions and observations which I can then react to. Sometimes they are useful.

Journaling also helps overcome inertia. Left to my own devices I might spend all day on hackernews, Twitter, YouTube, and taking care of kids. When I journal though I document my frustrations with living that way and that helps push me to work on my side projects more.

Further, just the act of writing things out helps me get started. If I have this nebulous idea that I want to work on "an idea" it's hard to actually start doing it. Decomposing a big idea into discrete chunks is inherently productive - it's drafting a plan and thinking through the system end to end. When I've written out a plan I have something specific and actionable to work on and my mind is already in the "Work on X" state.

Note taking has also helped with ideation. Last night I wrote that I wondered whether Spotify would ban Joe Rogan and challenged myself to predict whether or not they would. While I was writing a brief argumentative essay to myself making my case (low confidence they do ban this year) I came to hold an opinion on Spotify the company (long straddle). I was then able to queue up a buy order - which I wouldn't have done had I not been note taking. (Although, whether or not this idea was good for me remains to be seen)
Who's left (as large distinct publishers/studios)?

- Sony

- Microsoft

- Electronic Arts

- Capcom

- Ubisoft

- Nintendo

- Konami

- Square Enix

- Tencent

- Take Two

- Warner Brother Games

- Embracer Group

IP license biz model (Disney, Sega, etc...)

I'd include Valve, but they just don't make games anymore

edit: Added Embracer
“Always makes me wonder how many dysfunctional companies are out there letting deadbeat remote employees collect paychecks and do as little work as possible because nobody cares enough to press the issue.”

It’s not only remote people. I have seen multiple people at my company who are basically incompetent or lazy and produce nothing of value or even negative output. Some of them get let go after years and some of them get promoted into management.

Having a pleasant demeanor can get you very far without doing any work.
>([I] think you should be able to do pretty much whatever the eff you want with your body and money). ... The decision to let the exist is as arbitrary as the decision to allow them to only play when they [win].

How do you square that with giving people autonomy? You can do what you want with your money, but you can't play if you don't feel like you are gonna win... there is an inherent contradiction there.
Used to work at Citrix for three years as a Product Manager. I empathize with most everyone's experience that they shared- at the tail end of my tenure, the company prioritized the sales teams over the engineering staff and unfortunately it showed within the product.

I think when set up properly, Virtual Apps and Desktops is killer for having good access to desktops and at the moment is a good extension of Azure Virtual Desktop. However, it did feel like we were running the product with a skeleton crew. As a result, documentation fell by the wayside along with other matters. I guess complete PE takeover of this sort of company is inevitable.
It would be nice if we had the option to ask for $1 to our visitors, but we don't because the credit card and payments racket works its magic. Just what are websites supposed to do to survive? Shutting down is not a valid answer

Of course the #1 culprits are the advertisers themselves, because they don't care about their craft, they are lazy and just push all their money to google. But the web should be like an arcade machine where people can pay to get content, and current regulation makes that impossible
Well, there are various other modern trends:

* All stock market stuff feels modern, because 15-year-olds don't talk about it but 25-year-olds do. So it feels like something that wasn't really around/popular when you were young.

* Some would say retailer investors who want to buy individual stocks should be holding them for the long term - and that a mobile app, letting you trade on the go, is an anti-feature.

* The rise of Reddit's Wall Street Bets, who glorify moves that seem really dumb.

* The rise of Cryptocurrencies, and/or their marketing to unsophisticated investors. If I put my entire life's savings into Dogecoin, does that mark me as someone so dumb you should save me from myself?
See https://news.ycombinator.com/item?id=29427068 for a discussion about that, from the top comment:

> This is a terrible description of what the law actually does. Let's shine some light on the FUD. The law, H.R. 3684 (as enrolled), defines an "advanced drunk and impaired driving prevention technology" as a system which can do /one/ of the following:
1. "passively monitor the performance of a driver... to accurately identify whether that driver may be impaired... and prevent or limit [car] operation if an impairment is detected."

2. "passively and accurately" detect whether someone's BAC exceeds the Federal limit, and prevent or limit car operation if it's detected.

3. Both.

This will apply only after the DOT finalizes a rule describing what all those things actually mean in terms of manufacture. The law requires that the Secretary publish this rule within the next three years, unless they think it can't be done, in which case they can push it out another three years. That rule must give car manufactures at least another two years to implement the requirement. It also gives the DOT an out to say that it can't be done, in which case in 2031, they need to write a report to Congress to say why it can't be done.

In software terms, this is a user story that was just submitted for development. It's Congress asking the executive branch to do some work, but not actually forcing them to do so.

(But in the far-right wing press, "request to explore tech that keeps drunk people from driving" becomes "bill will mandate kill switch!" because of the click bait sound of it)
> For Gmail, I currently use Gmail because it just happened to be the best e-mail 18 years ago, and it's hard to switch. There's very little about it today that makes it the best.

This really undercuts your message. Google is a leech on society and their products aren’t even good, but you keep using Gmail because it’s kind of a hassle to switch.

You could switch to a different email provider and use DuckDuckGo for search. But you don’t. So your principled stance against Google doesn’t even extend to them most obvious examples of not giving them your business.

But sure, it’s very believable that the days of their products being good are “long and gone”.