skysight-inc/HackerNews huggingface dataset:
One single employee at Pfizer created 10 vaccine candidates in one day.

> Now, the thing is that you can’t just sequence a virus, do bioinformatics, synthesize mRNA and package it into a nano particle.

You can, and that's exactly what was done. However, out of the 10 or so candidates, they selected a few of the more promising ones to continue research.

They are fast to develop. However, there are other steps in the pipeline that aren't so fast.

> The mRNA that gets packaged needs to be modified (I believe with alternative bases) to achieve desired effect.

That's the easy part. The full mRNA sequence is not that large (https://berthub.eu/articles/posts/reverse-engineering-source...) and many of such substitutions can be done by algorithms. Now, maybe the modified protein won't fold right. That's not as easy (although, we can compute how it will fold now).

> If mRNA vaccine was as magical as it was marketed, we wouldn’t be getting 3-4(and soon 5?) doses of the same vaccine with the emergence of new variants.

If we were reckless and just wanted to inject someone with the latest update, this could be done in a matter of days. Human trials took months and people still complained that it was 'developed too quickly'. Then there's logistics.
Seems like PC gamers are the real winners here though, as both Sony and Microsoft have been releasing very nice ports of AAA games such as Halo and God of War. Definitely a fan of this change, although I'm wary of these companies abusing their monopoly powers in the future.
I had a similar thought. Like when Spain imported so much silver from the Americas and prices went up.

If supply of goods and services stays stable while money supply increases, the result is price increases. I don't know why this seems so hard for some people to understand.
A good chunk of Spain (based on my Twitter following) has been playing this one: https://wordle.danielfrg.com/
Oh hello!
I recently tried brave and was relatively impressed.
BAT is also an interesting idea, and I want to see it succeed!

However, I also had negative opinions of it like many people here before I really dug into it. I think your marketing really needs some work. I don't exactly know what it is - it might not even be your fault. The negative view of crypto many have has been associated with it. I would remove all mentions of crypto from your website. If people really want to know how the tokens work, they can go into the documentation. Having the word crypto on your landing page does you no good.
Cool insight, but that doesn’t explain the US, where most new money is created by private bank loans, not printing physical currency.
The same guy believes in homeopathy and that DNA can teleport via radio waves into a sample of pure water. https://en.wikipedia.org/wiki/DNA_teleportation

It's a whole thing. https://en.wikipedia.org/wiki/Nobel_disease
I've always felt like 1:1s, even when not "productive", are good breaks between work and great at building culture and connections.

Not every aspect of productivity in a company is about completing a specific task.
That part of GQL drives me nuts. How the heck do people do error handling on the frontend with API requests through GQL? Instead of `try catch`, do you do `if (response.error) {}`?
Termo – Portuguese Wordle
I miss the Bungie that pumped out Marathon, Myth, and Oni.

(I will look forward to people who were screaming that console makers mustn't be allowed to buy game authors and studios seamlessly turn a 180 if it favours their tribe.)
Typical retrograde article with a narrative I wish everything be like in good old days with no connection to reality.

The main message is super pathetic.

It claim simplicity but yet targets ICE car. The amount of parts in ICE vs any complicated EV is at least 3 times less. Sometimes more. So you just shift the complexity of running and driving super complex combustion engine towards your safety and comfort in EV and still car is 3 times simpler.

1. So one of points was no GPS. Who want to rely on your phone to know if you able to make to the charging station? What if you forget your phone and you're in the middle of highway deep in the forest?

2. Music. That's not even fun. Aux oh, yeah, how about ~1 billion people with iphone that doesn't have Aux. What if I want to play my music from my apple watch? And good luck managing several bluetooth devices with no screen. And what if some people doesn't want to rely on their device for such a basic thing as music? Really wiring your car with cords to charge your phone, connect aux, mount the phone is the way to make your car simple???? Are you serious?

3. Manual seat control. It seems like every argument in article is a denial of " i hate opinion and need of other people, I want my particular car". If 2 people or more own the same car, they want to adjust it automatically, including mirrors. I bet most of them will be happy to seat in a car, it read their profile from phone in the pocket, adjust seats temp etc including while driving out from drive way. That's already done in tesla including doors. No clicks at all. Screen is used when you need to change predefine settings. Even that can be altered via voice. Btw using voice is also more safe.

4. Climate control zoning. Same thing. How about people want it blow differently with different temp not for a different average temp in the cabin but for different feeling.
This is ahistorical. It wasn't the far right, it was everybody from the far right to the center left, and they didn't just censor porn and naughty words, they censored socialism, realistic depictions of slavery, descriptions of history that weren't hagiographies of slaveholders, all details of the red scare, accurate depictions of our wars, among a billion other things.

The ACLU has gone to shit, but that's because all institutions go to shit.

> Journalists now regularly host intelligence community propagandists

I hate to sound like a broken record, but "now"? I just don't know what media you watched that didn't do this. Maybe pick up a used copy of any Bagdikian from the 80s/90s? Or Project Censored?

I feel like young people who grew up on the internet, saying whatever the fuck they wanted because the tendrils of capital and the state hadn't figured out how to stop them yet, have no awareness of the very recent past. And it somehow turned them all into John Birchers.

The reason corporations are woke now is because right-wingers, centrists and apolitical pseudo-libertarians are going to vote in their interests no matter what happens. The only people who potentially oppose them are also woke, so the effective thing is to focus on getting as many of them as possible to ignore everything but racism/sexism/homophobia, which profits couldn't give half a shit about, instead of focusing on our kleptocracy, which is a necessity for profits.

I understand that the situation is oppressive, and violates your sense of justice and your basic ideals of an open society. Society has never been a spherical cow, it's been a production system sitting on the backs of women, minorities, and wage laborers. If you only notice the suppression of speech when it's largely aimed at scientific racism, men's rights activists, and people fighting for the right to spread disease, that says something about you: maybe not that you're a bad person, but that you're a young person, or a sheltered person, or that you've been inattentive to the world until it encroached on your ability to complain about affirmative action or accuse China of being an ancient evil enemy trying to kill us all.

Other people are trying to pay their rent and eat. You might have trouble trying to pay your rent and eat. But if so, name a single thing that woke fascism is keeping you from saying that's materially important to your life?

All I can say is: First they came for the Palestinians... then they continued to come for the Palestinians while white dudes were protesting for the right to say that women naturally hate math.
Can you elaborate on "what Google has been doing to C++"? Google has a couple of members on C++ working groups including WG21 but I'm not even remotely under the impression that C++ governance is controlled by Google.
It's working for me, here's the picture of the tweet in case it is locally blocked: https://i.imgur.com/dh1kU1q.png

Anyways it looks like censorship is thriving like never before. I wonder what' up.
The irony of this is that Rogue's popularity is due in no small part to their close partnership with Westside Barbell, a quirky club obsessed with both high-end equipment and steroid usage in equal measure. There's a lot of bad equipment out there, but the majority of people, training at home or in a gym, do not need Rogue equipment, and I'm willing to bet that Rogue has higher margins than some of the other good equipment manufacturers.
The vaccine wouldn't mess with sexual pleasure, something that hampers adoption of condoms. While condoms transmit pressure sensation just fine, the shearing sensation is diminished. Older men with mild ED may lose erection in the interval necessary to apply a condom. I believe there is space to disruptive innovation in the condom market.
The money supply is set by the Fed, which creates whatever is needed for Congress' spending bills.
If you live near a Micro Center, they always seem to have them in stock. They sell them in-store only.
I failed hard on an edit to pamd, which resulted in any password being accepted for any user. Anything but no password.

Not something I would usually test for, but lesson learned. Thank his noodliness we don't have ssh exposed anywhere outside our network.
I'm years out of date on this stuff, but I note the staging URL has found its way into Google as well, you might be able to fix that up by adjusting the <link rel="canonical" href="https://blog.staging.begin.com/..." /> to point to the authoritative URL even when the page is on the staging server.
"For both, high school was an afterthought, and they dropped out after four years to work fast-food jobs."

I mean, how many years is high school supposed to be?
My guess is it is more of a probabilistic thing than a strict threshold.
I have Pathways Into Darkness on my vintage Quadra 650 here. :-)

Also, we should play Destiny. Not to turn HN into LFG or anything.
I only remember video replies as a feature that allowed spammer camgirls to show their face on the related video feed
That’s a good observation. long reply chains do tend to turn to garbage rapidly. Either it’s an “in joke” meme chain (like used to consume nearly all Reddit threads) or it’s an argument. Which kind of makes sense because YouTube comments are a poor venue for valuable back and forth discussions so it’s just going to be garbage driving back and forth.
If they earn the equivalent of 30-50k (25% of a US senior IC), I imagine they can afford a decent standard of living, eg in Mumbai.
Such a great tool, has helped my organization embrace GitOps in concert with jsonnet and sealed-secrets.
Likewise, it would seem that after one vaccine using a given vector, completely unrelated vaccines using the same vector would be ineffective? So presumably they would eventually run out of all the accessible vectors.
> - So a we made a charging break every 300km, so approx every 2-3 hours

> - Recharging those 80% at a supercharger takes about 30-50min depending on the Supercharger-version.

How is this so totally different to the above commenter? I also need brakes during my rides and after a three hour ride a break sounds totally reasonable. But nowhere between 30 to 50 minutes?
Good on your dad! I also got my grandma to use a smartphone and she's even on Signal. But that's about the limit. My other grandma can't use anything that didn't exist in her life less recently than twenty years ago (DECT phones are the most hi-tech things she can use, even a dumbphone is too complicated). My parents as well as most parents I know struggle somewhere between the level of me and the former grandma.

Between age and tech-savviness there is most definitely a correlation, strong enough that I wonder about causation (with exceptions of course, though those usually have an interest and extensive exposure or practice). One exception doesn't make every >50yo a tech wizard who'll know how to explore new design patterns with confidence. I would assume that's why someone downvoted your comment (though it'd be nice if the people that do can give feedback by themselves...)
Perhaps. I only see it as a "subset" in the sense of: many things have to go right for good communication to happen -- ethos being one of them.

But its still "upstream" from communication. Philosophy informs action.

Your original point is that our leaders need to get better at communicating nuanced issues. That's a non-starter if the people in charge see nuance as an obstacle and straight up adopt an anti-nuance attitude.

My point is, they're bad at communicating nuance in the way that a bulldozer is bad at building a house. It just wasn't their mission. And that didn't become obvious until after these emails were leaked.
Its' not some impossible ask here. My 16k yaris beeps then brakes the car when going forwards into an obstacle. Why cant a 56k volvo do the same in reverse? It definitely has this technology, I think its mandated now, but seems to me OP is saying volvo didn't bother putting it on the reverse side of the car. Which is a little bewildering that a car manufacturer might consider a reverse collision impossible, and makes you wonder what other common sense safety things they've screwed up as well, or opted to knowingly not include to improve their bottom line.
I have the same experience. Most of the stuff I watch [1] is a lot less "meme-y" than I imagine the typical YouTube video, but I almost always check the comments and find either useful and/or funny comments.

It's a loooong way away from the comment section of just a few years ago, which was almost always full of rage, poorly-written comments, politics, and inside jokes.

[1] Sample of my homepage: https://i.imgur.com/IrmWii4.png
My Bosch gets everything sparkling every time on the eco mode (50 degrees, but takes nearly 4 hours).

The only time it ever fails is when something blocks a rotor and half a tray doesn't get any water on the underside.

But I don't think spraying more, hotter water at the clean half will help that.
from: https://sanaacenter.org/publications/analysis/8674

"The Sana’a-based branch continued to operate under Houthi control, having kept the vast majority of the central bank’s staff, informational archives and purview over Houthi-held areas, which include the country’s largest population centers, commercial markets, and business and financial hubs."

So, you split the country in two, one with "the largest population centers, commercial markets and business and financial hubs" but the loss of value of the currency is because the poorer side print more notes.

I suppose that when you have a hammer everything looks like a nail, and when you have a website about "sound money" everything supports your theories.
This John Ruskin quote came to mind!

"When you pay too much, you lose a little money - that is all. When you pay too little, you sometimes lose everything, because the thing you bought is incapable of doing the thing it was bought to do."
Shit I'm old. To me Rare were definitely one of the best game studios for NES and SNES: R.C. Pro-Am, NARC, Battletoads, Killer Instinct, Donkey Kong Country. I got into University when the N64 came out, so I did not play it .
> But if I told someone that I don't need to know the effects of v7.1.3 before patching it because I can't think of a mechanism for it going wrong, and besides, we already released all those other versions and they were fine, I'd hopefully be fired.

You are missing the point. If someone told you they are worried that your code is going to turn the CPU into strawberry jelly, you would be correct if you said 'there's no known mechanism that will cause that'.
One thing that may be nice is a pager mode. If you feed into more or less with a pipe you loose the syntax highlight.
Hong Kong dollar. Since 1983 $1 USD = HK$7.80±0.05.
Cuba is only one example. Most of Latin America and East Asia is in the 65-80%. It's first in Africa you find very low numbers, down to 0.2% in the Congo.
I think the point was that many on-site employees get their work done just fine, but spend half of their in-office hours goofing off on Facebook or reading HN or whatever. So in principle that "wasted" time (assuming it is indeed a waste) could be put to use for a different company, with double the compensation. Obviously there are severe logistical issues if you're on-site!
The only people who win in a lawsuit are the lawyers.
The issue is that some people believe in intuitionistic logic, so to them, there's a difference between assuming something is true and deriving absurdity in order to prove its negation (which they think is perfectly fine, and which is what Euclid was doing), and assuming that its negation is false and deriving absurdity in order to prove that it's true (which they think is a logical error). They reserve the term "proof by contradiction" only for the latter type of proof, i.e. the one they think is not a valid type of proof. Whereas for believers in classical logic, to say that something is true is just to say that its negation is false, so they don't generally care about the distinction between these two types of proof---as far as they're concerned it's a valid proof, and a "proof by contradiction", either way.
Wait, what is it about exporting only one variable at a time that makes it possible to determine dependencies statically? Why not two variables? Or three? If you're determining dependencies based on variable names it seems like that would be possible.
They make enough money precisely because not everyone ad blocks. This seems like a fallacious argument.
I've seen it too. Youtube comments for popular videos, alongside Twitter replies, is one of those places where the comments rarely seem made by an actual human
It feels the opposite way to me. Microsoft bought a company with an extensive suite of IP that publishes a lot of games. Sony panicked and bought a company that has one franchise (Destiny).

When looking at Disney, I see a company that has bought a lot of deep IP catalogues. They've used that to really propel their future and get high-value talent that wants to work in those universes with a Disney-sized budget to tell their stories.

Activision Blizzard may have cost 20x more, but Activision is really profitable with a P/E ratio of 26 (at the $69B deal price). Microsoft's P/E is 33, Google's is 26, Apple's is 29, Amazon's is 58, and Netflix is 38 (even with the tumble in price). So Microsoft bought Activision relatively cheap compared to its earnings. Bungie is private so we don't really know what their finances are like. Activision's cheap price means that there isn't a lot of risk for Microsoft. Maybe you believe that Activision is about to crater and no one will want their games in the future. It's possible. It's also possible that everyone is going to get tired of the extensive IP catalogues that Disney has assembled. However, when the price is that reasonable, you don't need the same explosive growth to justify the investment.

So Microsoft bought a business that even if it just keeps performing as-usual will be a fine addition to Microsoft. It also has the potential to be huge for Microsoft with a deep IP catalogue, the potential for Xbox exclusives to help launch the next-gen Xbox when the time comes, the potential for cost savings with Azure infrastructure, and probably more that I'm not thinking of.

If Sony buys Bungie and just lets them do their thing, they might get some good games. But it seems like Microsoft wants to buy and pour some money in which seems like a recipe for bigger successes. We've seen it with some of Microsoft's recent purchases. They've poured money into GitHub and made it an even bigger platform. They've poured money into .NET Core and Xamarin/Mono to recapture developer mindshare. It seems like Microsoft is likely to take similar steps with their Activision purchase - and similar steps that Disney has taken with their IP catalogue.

It's possible that the small places Sony has bought have better potential, but Activision Blizard is a profitable company at a relatively cheap price which means that the purchase carries relatively low risk while still offering a lot of upside for Microsoft.
effort / gain ratio is crap tho. Especially assuming IPv4 and reasonable firewalling.
AIDS and COVID are extremely different.

If you are exposed to COVID but got the vax a year ago, you’re likely to have symptoms. You probably don’t actively have antibodies. But that’s okay! You might have some symptoms, in fact they might be severe, but given enough time your immunity will ramp back up, and you still will clear the virus.

If you clear HIV after a week or two, that is a HUGE win for you.
To actually finish all the content in each D2 expansion you have to invest full time job kind of time in it.

Destiny doesn't just feel like a job, in some sense it IS a job.

I thought they did a good job rehabilitating the first game from the sorry shape it shipped in (see: the economics of the loot cave). It is a mountain which can be climbed, and it is fun to do so. (There is also a literal mountain to climb)
Because the Constitution and the Bill of Rights are a governmental founding document and only apply to the government. Alphabet is not part of the government, and therefore, it does not apply.

Discrimination by companies toward the public is covered mainly by Civil Rights Act (or the Americans with Disabilities Act in the case of discrimination based on disability).
> There’s a common factor to all of your 1:1s, so that may be worth looking into.

This was rude and uncalled for.
Myself, and it's has ñ
Transmissibility of SARS-CoV-2 among fully vaccinated individuals
Just wait what happens when people start to deep fake virtual interviews.
Maybe before saying furries are "jokes" and "weirdos" you should talk to a furry.

Calling people names says a lot more about you than it does about furries and "weirdos." I am happy you are in no way responsible for defining what the metaverse is or isn't.
Sony were making exlusive deals with Bungie for quite some time now with Destiny so its not that surprising.
... or the journalist misunderstood and misquoted the expert.
I really wonder how a heat pump can achieve so much efficiency gain. Heat of electric resistance is about 99% energy efficient: almost all energy is converted into heat, nothing else.
A tax on capitalization is fundamentally different than one on profit or income. A chip fab is a 20 billion investment over 3 or more years. They'd pay out upwards of a billion dollars before they begin to sell anything. Any domestic industry that is capital intensive with low margins or high risk would die.

A wealth tax is a terrible incentive for investment and growth of local businesses.
As a manager, you never have an immediate need for regularly scheduled 1-1 meetings. You can always just ask your directs for their time and expect to get it -- rare is the employee who says no to a request from their manager to talk.

Regularly scheduled 1-1s are for the direct, to have a dedicated, planned 30 minutes a week to talk, with a person who controls your access to food, water shelter and all material needs, but whose calendar is often booked solid. Even when there's no immediate need for clarification, approval or discussion, theres still discussion about promotions and career development that need to happen more frequently than once a year or quarter.
Doesn't redirect for me, also in Canada /shrug
People don't understand because they don't want to understand. Biden is just the latest President in a long line since Wilson who doesn't want to admit what causes inflation, because that would mean their spending policies are to blame.

It's better to blame everything else.
The answer is: everyone who's not toxic.