skysight-inc/HackerNews huggingface dataset:
Both the Oxford-AstraZeneca vaccine and Sputnik are using a pretty similar trick that gives them the speed-up. They still get to pick an arbitrary sequence, but they're smuggling it inside a virus instead of as mRNA.

That's why the codename for the AstraZeneca vaccine is ChAdOx1, it's a Chimp Adenovirus as host for the sequence. Take this mild uninteresting chimpanzee virus, but tweak it to tell human cells to produce your arbitrary sequence instead of itself. The humans become immune to whatever your sequence was (and maybe to Chimp Adenoviruses?).

I'm sure there are reasons this might be better in some cases, and it involved less bleeding edge technology which made it a safer bet in a pandemic, but the mRNA approach seems obviously more general and even perhaps more re-usable.
I do this with two notion pages. One is Idea Inbox for any ideas worth exploring later. Then a second page called Journal which is a running list of entries for each day. I pretty much work out of this page and use Idea Inbox to remember what to write about that day.

I’ve surprisingly seen health improvements as well.
JFYI, please at least mention the stated purpose of the cards before dismissing them.

> A tendency to see size over everything else may lead providers to misdiagnose patients in larger bodies and misattribute symptoms to size instead of the true underlying condition.

Their primary purpose isn't to deal with shame, its to ask doctors to not jump to the conclusion that the problem is the weight. There are examples in a linked article on the site: https://www.self.com/story/weight-stigma-kept-me-out-of-doct...

> Later, I found another doctor for an annual checkup. At the appointment, he physically recoiled at the sight of me. He quickly told me I’d need to lose weight before I saw him next, then left the exam room. My body was never touched, never examined. I learned nothing new about my health, and was left only with the searing shame of believing that even a professional couldn’t bear to touch my body.

> At another appointment, a nurse took my blood pressure four times. When I asked her if I was okay, she told me my blood pressure must be wrong. "Obese patients don’t usually have low blood pressure," she said. Even my health was impossible to believe.
Are you saying that lizard theory is fairly analogous to physicians questioning the efficacy of health protocols during an unprecedented global pandemic?
If you've worked with an engineer that "intended" to accrue technical debt, I feel sorry for you but I hope you realize how uncommon that is.

Technical debt is the answer to management requests that cannot be accomplished in the requested time with the available resources. No more, no less. The word debt refers to the fact that the shortcut needed to do so will cause problems repeatedly in the future (interest that will need to be paid).

In my experience, engineers will make this clear to management, and will point out the additional time needed to implement a solution that avoids those problems, and management will make the decision to continue as is.

For a concrete example, management requests that you implement real-time collaborative editing in an existing tool. You have enough time to replace all the backend stuff with a CRDT or OT based implementation, but the frontend architecture is not equipped to deal with collaborative editing and there is no time to do both with the people available.

So, in order to meet the management deadline, quick hacks are added to bolt on the collaborative UI on top of the existing UI. Eventually new features have to be added that simply cannot be supported in the existing UI architecture without massive workarounds. Carving out some time to slowly refactor the UI architecture is rarely done, so the problem accumulates until development speed slows to a crawl.

That is technical debt, and it's entirely a byproduct of management/development negotiations. Has nothing to do with engineers. Nobody could have predicted that the architecture would need to support an entirely different backend in the future.

EDIT: Just to be clear, technical debt happens as a result of a conscious tradeoff between one or more options, where the more problematic option is chosen to get to an "acceptable" solution in a shorter period or with less resources. Some dev writing a shitty architecture is not technical debt. Depending on a library that later gets EOLed is not technical debt.

Figuring out you have a shitty architecture or an EOL library and choosing to continue building on it despite clear evidence it is a bad idea, in service of shorter time to market, that is technical debt.
Picasso's Descendants to Sell More Than 1k NFTs of Never Seen Ceramic Works
> high-risk low-incidence diseases like this conducted

If you're asking 'how do we test the vaccine without _trying_ to give people HIV", one option is to give it to a lot of people, and record their outcomes over time.

But first you need to prove the vaccine isnt like, super toxic in humans. So you do animal analog tests, then a limited test on humans, aka "Phase 1 trials". A previous article summarizes:

> Moderna’s vaccines passed Phase I testing earlier this year, which involves testing for safety using only a handful of human volunteers. Phase II tests for a vaccine’s overall effectiveness, and with the move into Phase III, Moderna will be looking at its efficacy versus other prevention treatments currently on the market, such as pre-exposure prophylaxis, also known as PreP.

- https://www.them.us/story/moderna-begins-hiv-vaccine-trials-...
Hoping the prices drop
Why do you feel you deserve free kindling?
I only knew about popcorn with salt and popcorn with sugar. Is popcorn topped with ground beef really a thing?
Still not a protected class, which means the bar for proving discrimination is going to be pretty high. Especially if it happens after you've been hired.
Yes, but what I meant was those would be already approved.
I'll be in touch you can be sure. Code is in GIT but I will not make it public until I have UDP working --- hopefully +/- 3 days.

I do and will continue mention your paper (which I also found on HN) and your repo because it has a lot of really good ideas ... ideas which I'm forced to engage to mastery.

I haven't yet had time to focus on how you deal with packet loss via and with congestion management. Anything you can do --- I'll have to reread your paper (well written BTW) to pull my own weight here --- is a real benefit to the community.
This is true sometimes, but a few things happen as you keep writing software:

1. By writing the needed code the "debt incurring" way, you learn how to do it the "right" way. So you may start with inexperience, but you gain the experience and are now better able to fix the issues you introduced.

2. Similar to this, even if you have all of the necessary experience and skill, you still may not be fully able to picture how the feature will need to evolve in the future to support additional use cases. Once you see that happening, you can design a better implementation, but not before then. Sometimes you have to do it wrong to get the feedback you need to do it right.

3. There are often real tradeoffs that get made that aren't about skill, but about time. I don't think you can discount this situation, in my experience it happens very, very often.

A great way to avoid nearly all of this is to just set "EOL criteria" for your software. "This project will not work beyond 100 users." or, "This feature will need a rewrite once we have to account for the edge case we ignored in this implementation." Know the limits of what you've built, and make it clear that you need to rebuild once you've reached those limits, and it's at least marginally more likely you'll get the support you need from the people with the purse strings.
They're not investing unusual amounts in new fabs, nor are they investing in anything but the cutting edge.
2 out of 7 macaques didn't get infected after 13 weekly (anally administered) exposures to SHIV. The other 5 averaged 8 exposures before infection took place vs 3 exposures in the control group.

That's actually pretty good at preventing infection - 28.5% avoided infection completely, with the remainder clearly having a much more robust immunity than control.
> For most of the world, bidets are a thing an it is a curious thing as to why the toliet paper industry is so powerful in the west.

At least in America, my Grandmother's generation (great depression) grew up with outhouses. When homes were renovated to add an indoor bathroom, they were done on the cheap.

Heck pre-pandemic the idea of a bidet was crazy, I had to work hard to find one that was reliable and at a good price. Now they are super available and advertised all over the place, but when I went to get one installed 10 years ago it was not easy just finding a reliable, cold water, model! Warm water models were obscenely priced in the US.

It was likely a chicken/egg thing. Consumers didn't know about them, so no one made them for the US market, which meant the few that did exist cost an arm and a leg, so no one bothered to buy them so no one bothered to mass produce them.

On top of that, when I inquired about getting an outlet installed behind my toilet for an electric bidet, my plumber and electrician thought I was crazy!

Same question in 2021, "sure we do that all the time".
The one that really surprises me that people take like candy is Tylenol/Panadol/Paracetamol/Acetaminophen. It's the leading cause of acute liver failure in the US. Among common OTCs, its active dose is I believe the closest to its lethal dose. Just 2-3X the recommended daily upper limit can cause liver damage, and when taken around alcohol, the toxicity is dramatically higher.

I strongly doubt that Acetaminophen would be approved as an OTC drug if proposed today.
>
The covid-19 vaccines were very effective at preventing disease and spread until the omicron mutation, which perhaps wouldn't have happened if not for vaccine hesitancy.

I'm happy to piss in the coffee of vaccine hesitants any day of the week (point me to the mug), but we can't blame the variants on vaccine hesitancy.

Both delta and omicron originated in unvaccinated populations in the developing world, where the problem is not vaccine hesitancy [1], but the lack of availability of vaccines [2].

[1] Delta arose before any vaccines were approved, and yes, of course, there's vaccine hesitancy in South Africa, but there's also, simply put, not enough vaccines to go around.

[2] For some mysterious reason, our economic planners thought that getting the developed world inoculated in 2021, and the developing world in 2022 was a smart plan. It wasn't, but now we're reaping the consequences of it. I eagerly await the next variant.
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Does Bungie even still own the rights to their older catalog (not counting Halo obviously)? Like Myth, Oni, and Marathon?
The Plan to Put Bitcoin in Mouse DNA with a Genetically Engineered Virus
TiVo is very much a part of the digital age, it's literally called a "Digital Video Recorder".
>Always makes me wonder how many dysfunctional companies are out there letting deadbeat remote employees collect paychecks and do as little work as possible because nobody cares enough to press the issue.

Probably the vast majority of companies! If you ever get an employee like this as a direct report and try to do something about it, the process is incredibly draining and shitty. Easily the worst I've felt about work in my career (so far!). I see why people try to ignore the issue, but it also feels pretty bad having your other team members constantly pick up the slack around a non-performing team member.
Funny thing: I'd classify Plato's dialogs as immoral debates by this definition. (Admittedly that's debatable. You could say they're not debates at all, for instance.)
I don't follow your logic. Because Fauci, Trump, Biden said things that turned out to be false, new medicines can no longer be created?

Or are you saying that new medicines can still be created, but you will not take them out of spite toward the lies told during the pandemic?
That sounds like an argument for better payment mechanisms but people still need to be paid.

Yes, people paid for content prior to the internet but there were also problems — many good things went unnoticed because not enough discovered them while plenty of garbage got tons of attention because the creator had some personal connection to publishers, reviewers, DJs, etc. One of the things I loved about the rise of the web was that it provided so many opportunities to find things which weren't going to run in my local newspaper, be stocked by the local book or music shops (if you weren't lucky enough to have good indie options), or the pile of mud a lot of the big radio stations were often playing (this got a lot worse in the 90s when Clear Channel started buying all of the radio stations so questions about what got mainstream coverage in many markets came down to what one guy in Texas wanted).

I don't want to lose that — whether it's counterpressure to the huge race-to-the-bottom advertising market for more selective sponsorship, something like Apple/Stripe Pay to make it super easy for people to get paid for their work, etc.
We once had a contractor who interviewed pretty well. After a while I noticed that it was impossible to have a technical discussion with him. He only took notes and never said much. I also noticed that he never delivered anything the same day. He took notes and then next morning it was done. I once told him to fix a simple bug NOW and had him sit next to me. He starred at the screen for several hours and did nothing. And not unsurprisingly it was done the next day. We came to the conclusion that he had a ghostwriter somewhere else who would do the actual work from the contractor’s notes.

Problem was that the ghostwriter was not a great dev either and wrote bad code. So we had to let him /them go. The contractor is now a principal developer/ team lead at another company……
> Yes, advertisers can and do try to invade subreddits posing as "real" users to promote sham products. But I haven't seen this actually working

Would you know if it did?
If you run "serverless" It's all hidden from you.
Wait wasn't Bungie a MS division at one point?
It’s quite possible the guy was running 3 or 4 jobs at once. It happens.
I would imagine speed/cost/aesthetics. The builders aren't going to think about long term repairability and few home owners would know to think about something like this or come up with a workable (and code compliant) solution.

We have had to be extremely diligent with our contractors because of the number of times/things they do where they just operate on the autopilot of what is typically done. Its human nature, but the norms in building homes to me are just wildly outdated. Wildly.
https://features.propublica.org/the-bad-bet/how-illinois-bet...

https://www.propublica.org/article/illinois-video-gambling-w...

These are interesting reads regarding slot parlors in Illinois. It gets repeated in every locale that legalizes slots. Big promises of increased tax revenues, then the actuals are 10%-30% of the forecasts, but by then the horse is already out of the barn. I've looked at a few state level gaming commission data sets and backed out the math, and even in backwoods areas, penny slot machines generate $20/hr average ($240/day) in gross income (even though they're called penny slots, you can easily lose $20 in under 60 seconds based on speed of play, number of lines and bet sizing-- all of which are heavily optimized to trigger reward centers in the brain), so even with expensive $5-10k machines, the recovery time is pretty low, so they'll just metastasize as much as legally allowed.
If you can, I strongly recommend spending $300-500 on a receiver with CarPlay/Android Auto support. The install kits are so good they often look like they're stock installations. I even was able to replace my cigarette lighter with a USB port, so there are no unsightly cables sticking out of my dash or anything.
I'm using the legacy free edition since 2010 for personal/family propose. When I signed it I don't remember any legal note that Google can close my accounts and send me to the hell. It's a really nightmare!
note: 'proscribe' means to prohibit and 'prescribe' means to require
I feel that there is a generational gap between Youtube users that correlates with whether they will pay for premium or not.

People in their late 20s and 30s who remember Youtube as a catch-all location for lo-fi homemmade videos with few ads may not feel that YT premium is worth it, particularly if they already use adblockers, and don't use it much on mobile (where adblocking isn't possible without modded APKs). This generation also remembers torrents and Limewire, before Spotify made everything super-convenient.

Those who are more familiar with 'modern Youtube' with multiple pre-roll ads, clickbait and and influencers everywhere may be more receptive to paying just to get rid of the constant ads.
Saving cash, because the obvious situation is to wait for the crash. It’s going to happen and then I won’t be wasting 2/3rd of my money on the inflated market investment value of what is one of the basic human needs. Real estate as an investment is the sand that a big part of the currently precarious global financial situation sits on. It’s going to collapse in my lifetime and I’d rather be sitting on a pile of cash the moment it happens than be leveraged hip deep in some stock brokerage unable to turn my cash into the one thing my parents and their parents generation got to take for granted, ownership of the land they lived on.
An old decent writeup on the history of VWRAP (formerly Open Grid Protocol, and MMOX before that) can be found here:

http://www.metaverseink.com/blog/standards/virtual-world-int...
> "My wife wrote all of those."

There was a place that hired a consultant for a project a friend worked on, and she was... I don't think she could write code at all. Like, had trouble manually inserting fragments into an XML file despite fragments with the same structure already being in the file.

Her productivity skyrocketed at night however, and she generally had working code in the morning, which lead to rumors that her husband or someone in her home country was doing the work (would have been daytime over there). Nobody really complained. She wore a hijab and the company had just hired it’s first “diversity officer” so maybe that’s why. Thankfully they stopped using that vendor not long after.
This is something I had to teach my dad. But he believed it thoroughly until he had a few high purchase items fail outside of warranty. My advice to him has been look for customer reviews and he suspicious of the positive ones and aware of all the negative ones. My other advise is buy from a reputable distributor like Costco who makes returning something incredibly easy.
title (and Twitter post) highly editorialized. Google said nothing about layout of ads on page, but about being "clearly marked" and "set apart" from search results. It's subjective what is "clear" but I don't see why the only way for something to be clear is delta X.
Yep, it's unrelated. In Michigan, in-person sports betting became legal the very same day the NBA paused their season due to Covid. Online was always going to come after that, and took about 10 more months before it opened up. There wasn't any particular rush.
I swear the ad industry are in bed with cellular operators. Data usage from ads taps directly into peoples data plans, why would not there exist a kickback scheme for this?
I think this is a very biased take on it. The vaccine was developed under Trump and he heavily promoted it over the summer of 2020 and into the election. He took credit for it so much that Kamala Harris said she was not interested in "a Trump vaccine"[1] during the lead up to the election. Oddly enough, I don't hear much criticism about that. Instead the focus is on what Trump said 6 months before that, when the virus was brand new.

[1] https://www.nbcnews.com/politics/2020-election/harrris-vacci...
The thing that gets me with the success stories is the issue with risks and planning for success only.

When you’re driving in the colder parts of Europe it’s generally advisable to keep your tank at least 50% full all the time. If the shit hits the fan, like it did for me in Switzerland once, and you’re stranded for 4 hours due to a crash out of your control, your car becomes a fairly important life support system until the road is cleared. There is no recovery option when there are a few hundred cars in the same shit.

So you’re 3 miles from a supercharger with 15% battery left and your car is a frozen brick in under an hour. You can’t deliver more fuel to it and your efficient route plan is a liability and there’s a queue of bricked EVs waiting for flatbed recovery.

I’m not criticising the concept but the current execution and the perception of it.
But with ease of use and advertisements, you can dramatically grow the set of people who want to gamble.

I watch football with my kids, and now they want to try gambling, after seeing thousands of sports book ads. I find it really depressing.
What’s airflow?
Yeah it is quite a jarring experience when Adblocking breaks for whatever reason.

Actually built a small internal api end point that checks whether filtering works every 60s and that goes onto status tracker (Kuma)
If a HIV vaccine really is happening, that will really brighten the memory of the last two COVID years.

And as always there are some great insights to the inner working of the vaccine, Hacker News doesn't disappoint.
A few years ago I had to use my mom's laptop to order dinner or something, and I couldn't figure out why the page I was on looked so weird. I double checked another site I visit regularly, and that site looked weird, too: huge background images, videos everywhere, weird fonts, etc., etc. At first I thought her machine had a virus, then it dawned on me it was all ads! I installed an ad blocker, and the difference was night and day! The unfiltered pages were basically unreadable.
Meh, all these exclusives sound like they are just going to shoot each other in the foot. Gamers will end up with both consoles (sold as loss leaders) and spread their investment in games between the two. Lose/lose.
Buy the one from Harbor Freight, return it when it breaks.
I'm also an atheist. You don't need sermons or allegories to be a good person in my view.

Ethics, as a concept, and behaving in a ethical way is mostly common sense: Don't harm others, etc.

If you want to go deeper, however, you'd probably be better served reading on the Philosophy of Ethics, rather than religion in my view. Try read up on John Stuart Mill, Immanuel Kant, et al.
Funny and malicious web server banners
Very common with overseas contractors. Often the person communicating has good English skills, but they swap in a friend etc for the actual work.

In some cases fine (you'll actually get both of them to eventually show up on calls together with some random excuse). Other times less fine (basically a scam).
Pretty much my approach too. The one channel became too horrible so switch back.
Whoa, that's really impressive, I like the extra touch with GitHub.
The company I remember them criticizing was Alta Vista, which did include organic search results intermixed with ads at the time.

>Google may be big with the cyber-cognescenti, but AltaVista is still reaching a lot more users. While AltaVista reaches 17.7% of Web users, Google gets just 7%, according to the latest Media Metrix numbers.

https://www.forbes.com/2000/10/20/1020alta.html?sh=68521b3e7...

They weren't bought by Overture until 2003.
No specific example but this article gives an idea of what's going on - https://www.bbc.com/news/world-europe-11789671
We have a bunch of HDX 3D Pro VDIs at my current place and I second this.