skysight-inc/HackerNews huggingface dataset:
The booster will become a regularly changing shot.

Here the comment about variants as described in the original paper..

Vaccination before or after SARS-CoV-2 infection leads to robust
humoral response and antibodies that effectively neutralize variants. This is because all the variants have common elements that are not expressed via the spike protein based RNA vaccine. Pfizer is modding their booster to add all the new mutated bits and pieces to it.

In essence the viral RNA genome enters the cell. It is then broken
apart into it's subunits of smaller RNAs.
These are then replicated in the cell by the ribosomes. The product of
the ribosomes is then assembled into new viral genomes which usually
exit the cell when it gets full and bursts - it might also use the
apoptosis mechanism to release the newly made virions.
These fragments are subject to mutation as the ribosome makes them =
many diverse fragments, some functional and some non functional = more
variants, most of which are crippled and will not work in the viral
genome.
The infected cell also displays these viral fragments it is busy making externally as immune
system cue molecules = body creates antigens against them. This huge
diversity of antigens yields a superior antigenic response to the one
induced by the spike protein alone - which can miss the mutated ones.
What this means is the spike protein antigens Plus all these soup to
nuts antigens that you arrive at after vaccination + booster +infection
is better then the fine tuned spike alone immunity.

They have (Pfizer) have sequenced the Omicron and all the prior greek
letter genomes, and they have selected all the functional fragments
and have created RNA strings to add to the vaccine, so when Pfizer
releases it's next vaccine it will include the current new spikes Plus
the RNA to make a number of these fragments.
They are trying to find all the 'critical' sequences that are common
to all Covid strains. Once they determine these completely they will
be able to make a vaccine that stops all current as well as all new
mutations. Many other companies are doing the same thing, so in a year
or less a definitive vaccine will be possible.

This might mean the end of Covid, but it might not as Covid antigens
fade with time. The body retain memory T cells, in small numbers, and
whenever a new infection occurs it is assessed by the memory T cells
and if it a known diseased, the T cell then reproduces greatly - it
take 4-5 days for this response to mount, so a very efficient
replicator like Omicron is capable of replicating faster than the T
cell response can mount a defense = infection - usually mild and short
lived as the massive T cell response will kill any infected cell once
it mounts.

If you are interested and have the time, these two links go into it
chapter and verses.

https://en.wikipedia.org/wiki/Immune_response

https://en.wikipedia.org/wiki/Immune_system

A recent paper also assesses the immune response to 2 vaccines + a booster + a mild infection after (or a more serious one before one or more vaccinations) as giving a very high degree of protection against all variants.
The ultimate example of form over function
Of course he can take a stance. And by the same token the rest of us are free to criticize it.
It's exactly the opposite for me. All other mice are way too high for me, holding them feels weird, clicking and scrolling motions feel cramped, and it doesn't get better even after months of use (had to middle-click a lot last year). I seem to be holding the Magic Mouse in a way that doesn't cause my wrist to twist as far, halfway like a vertical mouse, which I think is part of the reason why it works so well for me. Can't do that with more conventional mice because their shape forces you to hold them in a certain way.
The media is in full scramble. Trudeau is in hiding. The police and powers that be are trying to scare people. And others political figures are trying to get out of the way.

Meanwhile you have families, kids, women all standing around in negative -30 temps. The 7 year old holding a freedom sign doesn't seem like a white nationalist coming to kill Trudeau.
At least as of last year the FTB website still didn’t take parenthesis either. Pretty sure it is a ham-handed approach at sanitizing the input against sql injection.
It only applies to non-canadian truckers doing cross border trips...
https://www.canada.ca/en/public-health/news/2022/01/requirem...
I really want a search engine that works more like a database. I want to see why it returned the results it did, like an EXPLAIN syntax does for SQL queries. I want fine grain control of the actual query, and ability to sort the results by different facets.

I think there’s 100% a market for a new search engine that is geared toward the power user, the researcher.

Google hasn’t innovated their actual search engine in ways that actually benefit the user in years. The only changes they have done have been driven by a profit motive.
I just looked it up. They advocated changing the terminology to “minor-attracted persons/people.”

I agree with the critics in that seems like a way to destigmatize pedophiles, but I also think our current policies on pedophilia do nothing but force them underground. If the end goal is to prevent children getting molested, we need to somehow break down the barrier of treatment. I don’t know much about this, but I would think that treatment would be medications that suppress their sex drive. I guess I would personally advocate a way for those medications to be taken anonymously.

That’s neither here nor there, of course. Free speech isn’t free speech if it isn’t absolute, and as long as there was a good argument with the above I would think it would be welcome at this university. Apparently not, though.
Are there good tools which let you manage a catalogue? Either SaaS or self+hosted ?

It is hassle to manage your own files on all your devices.I would rather i had app like Spotify but streaming files owned by me.
Perhaps you didn't know, but Neil Young tried to get Spotify to deplatform Joe Rogan (i.e., to cancel his Spotify distribution deal), and used his repertoire as an ultimatum.

EDIT: I'm being downvoted to oblivion for stating an objective fact. This is unbecoming of HN. I'm out.
The point is that your scope as a constituent is traditionally limited to your voting jurisdiction.
Re: cheap shots at web3 and crypto regularly rising on HN?

I started a thread here to collect well-aimed shots at web3 and crypto: https://news.ycombinator.com/item?id=30132617
Likewise. Nextcloud Music and Subtracks. Glorious.
Can you truly love something that makes you constantly paranoid?
Web3 is full of hype, ponzis and fraud, but as a builder it's easy to get excited about what can be built with permissionless, programmable money and tokens.

"The only “utility” for a cryptocurrency (outside criminal transactions and financial frauds) is what someone else will pay for it and anything to pretend a possible real-word utility exists to help find new suckers."

This is simply incorrect. Just as a simple example: Being able to accept money for freelance work (whichever country you reside in) without paying Upwork 10-20% of your pay or relying on other intermediaries is "utility" no matter how you twist or turn it.

People who categorically dismiss cryptocurrencies or web3 as useful technology should probably check their biases.
Young and Mitchell pulling their music is literally freedom of speech (free expression). Neil Young can do whatever he wants with his content (speech), just like Rogan. This is competition in the free marketplace of ideas.

You're absolutely entitled to your opinion on these actions and you're free to support Spotify or Young or Mitchell or any combination of the three. But there is no "freedom of speech" side here.
Better to go with a throwaway per topic.

Otherwise in ten years we'll be reading an article on The Atlantic that leads with a CEO behind bars, jumps to a young kid learning about the world in his uncle's Pizzeria, then to a shady security team searching for the whistleblower by cross referencing HN posts against employee catering habits, and finally a retired FBI agent that steps in to provide protection.

So yeah, pizzasnob, please don't start talking about your love for dobermans.
My understanding is that while some idiots are putting links to S3 servers like you describe that some NFTs use IPFS links which AFAICT are not vulnerable to being taken offline.
Pretty great price discrimination model - at least in the short/medium run.
Because Apple controls the entire stack.

From processor, to boards, to OS, to the walled garden of apps.

No other tech has that level of control.

Think of the controversy surrounding the Intel ME and other “secondary processors”.

Not an issue with the IPhone (from Apples perspective).

When Google decided they wanted to control all the computing on their servers, from bare metal up, they ran into the ME.

Apple is the only key civilian entity with that level of control.
It's not just ridiculously-sized power bricks designed this way... do a Google image search for wifi extender and be amazed! Had trouble finding one with a cord.
No, it’s “then invisible hand of the market”. Neil Young is removing his product from a marketplace he disagrees with. This is exactly what people keep saying we should be doing to affect change, let our wallets speak. Except when they don’t like it. The truth is that boycotts are ridiculously common across the political spectrum and throughout history.
I had early influences. Those habits formed in my teens. HAM radio guys. Seriously.

Every one of them had all manner of crap in the garage or work room.

You should pick some stuff. Get kits. Tool up to build them, then tool up again to make them work, lol.

Could be anything too. Have some fun. Make sure you put some consistent time in. Works like compound interest does.

I ended up doing a hard career change in my late 40's. From enterprise software to additive.

Suddenly, all that fun time paid off. I could do a lot! Had no real idea.

Went from dread to excitement again. Cannot recommend this stuff enough.
Windows 7 was also EOL in January 2020. I’m not sure I blame Python 3.9 for failing to support an EOL operating system either.
My understanding of the GMO debate is that there are two kinds of GMO development: there's GMO for the purposes of making crops themselves hardier, more nutritious, etc., and then there's GMO for the purposes of making crops more resistant to novel pesticides, herbicides, etc. The agricultural industry likes to conflate the two, since the latter is much harder to defend.

I have no idea what Neil Young actually believes (and I don't especially care), but I do know that it's possible to be pro-GMO (or even just neutral) in the first sense and anti-GMO in the latter sense. And that's the position that I've seen otherwise scientifically informed people take.

(This is ignoring some other reasonable responses, such as "what do GMOs have to do with Spotify?" and "why do you think that being anti-GMO makes you anti-science?", but there are only so many hours in the day.)
That might be the very definition of a wasteland - when Dominos is the best in town.
I love literate programming. But it requires 3 skillets: writing well, programming well and a little DevOps in order to automate the execution of the literate program.

So it is actually very difficult to do... But the results are Worth it to have software you can understand forever
I always get saddened when I read an obituary post on HN of some great people I only got to know because they recently passed away
Salvatore’s was better.
There's a grocery store in the Southeast called Publix. They have a pretty awesome deli. You can order w/o creating an account. All you need is name, phone and email. You can give them a fake name, phone number and email if you want. You don't even need to pay on-line.

Any specials they have the week gets applied without an account, unlike other grocery stories (Looking at you, Kroger...selling customer's digital data).
It was their downvote that came with it. Also, their recent comment history.

Otherwise I’d agree
Man, I wish there was a program on linux/mac/windows that would show this. (I sell USB-C cables, and like to verify what the cables compatibility is before claiming it can do xyz.)
Isn’t this just life/humanity? No one is ever gonna have a 100% scientific correct moral applied equally to all of their life. He is gonna protest some stuff and not other stuff. I’m not really afraid of a slippery slope here. I think the bigger problem is people not taking a real stand in what they believe.
Is that not speech?
Windows Update hijacked to infect PCs with malware
Fair points but that's hardly the buyers fault, no? The Bitcoin and Ethereum networks have been humming along for a long long time before the NFT wave hit.

RE: competing for hires and investors, hmmm. I do agree but I question how long will they last so it's IMO a self-correcting problem. I might be wrong though; I've witnessed companies with literally no product to sell coast on investor goodwill and general hype (to my amazement and dismay) for years.
Ironically, I picked up Dominos pizza for the first time tonight in many years.

The app and the screen on the wall said that my order was ready for 10 minutes while I stood there waiting for them to finish my order.

The food was terrible. Their chicken actually used to be good! Tonight the whole thing was just gross.
Pixelated blurring is I’m sure prettier than black rectangles, but it carries the potential to cause major legal pain to whomever implements it as a way to “hide” sensitive information.
You’re right. I was simply mistaken and thought it was published by Microsoft.
I like Joni Mitchell and Neil Young. However, if I didn't, I simply wouldn't listen to them. Which is exactly what I do with Joe Rogan. I tried his show, it wasn't for me.

It's interesting that Joni Mitchell also promotes controversial and unrecognized medical information, such as "Morgellons Disease"

See: https://www.billboard.com/music/music-news/morgellons-diseas...

> The 71-year-old singer first discussed her battle with Morgellons in a 2010 interview with the Los Angeles Times, telling them she had “this weird, incurable disease that seems like it’s from outer space.” Her vivid description left many fans concerned: “Fibers in a variety of colors protrude out of my skin like mushrooms after a rainstorm: they cannot be forensically identified as animal, vegetable or mineral.”

and https://www.mayoclinic.org/morgellons-disease/art-20044996#:....

From the Mayo Clinic:

> Some doctors recognize the condition as a delusional infestation and treat it with cognitive behavioral therapy, antidepressants, antipsychotic drugs and counseling. Others think the symptoms are related to an infectious process in skin cells. Further study is needed.

And Neil Young isn't without controversial opinions that go "against science" on issues ranging from GMOs (he's against them), to the benefits of super-high-resolution digital audio files (he's for them).
I love that the event included “a self-customisation bar”. Do you think you could amputate a limb? Or far more exciting to me, add one?

This tantalizing phrase was sadly not explained by the article.
When did the web "release"? Seems like you're placing it around...1990? Why not Arpanet (1971)?
I have a poor understanding of electrical engineering so I am not sure this would actually work. But I've wondered if one could make a fairly cheap gadget for turning a decent USB-PD supply into a somewhat useful hobbyist variable voltage DC power supply.

Especially with USB-PD 3.1 which has an adjustable voltage supply mode [1] so you are not constrained to only a handful of power profiles. I think in theory you could offer 5V, 9V, and 15-48V.

It would be cool because it would be much easier to carry (keep in your backpack) and I imagine cheaper than a benchtop power supply so long as you have access to a capable USB-C charger. But I'm not sure what you'd be missing out on versus a proper benchtop.

[1] https://www.usb.org/usb-charger-pd
Also there is a certain lack of training in clear thinking with words and ideas that are not emphasized in STEM curriculum but are emphasized in the humanities. I took a fair amount of history and literature in college, and while they lack the clarifying reality of equations and axiom systems, the practitioners of such fields are quite good at dissecting statements and pulling out the subtleties of human language based communication. A group of upper level literature students would I think pick up on more nuance than a group of CompSci students. They are also exposed to a lot more nuance in their regular reading and work.
2000 years old and still speaking truth to our own lived experience makes it all the more authoritative.
Well, tapes have the ability to be easily removed, which is their killer feature vis-a-vis malware.
No disagreement on this point: everything is so decentralized, with very limited “official” content, that providing “authoritative” resources is quite difficult. That talk wasn’t even in Devcon, if I remember correctly.
Are they childhood survivors of authoritarian governments that turned into oligarchies? Maybe if they had been, they wouldn't be so convinced that rich and famous people should get to decide what ideas other people are exposed to.
It’s hilarious to me to watch the counter-culture heroes of my youth turn into establishment apologists. I suspect it’s the “anything for attention” syndrome.
The hole is (1) a detent that improves the socket’s grip on the pin, and (2) a way to lock the plug to prevent use.
If it's useful to use the same string literal character "as everyone else", it would be useful to use the same as a language you are very likely to see combined - so, single quote.

On the other hand, if it's useful to have minimum need of escaping, then single quote is still better, because in SQL it's much more common to quote identifier names than to have literal strings.

query = 'SELECT "columnA" FROM "aTable" WHERE "columnB" = \'foo\';'

compared to

query = "SELECT \"columnA\" FROM \"aTable\" WHERE \"columnB\" = 'foo';"
The linguistic choice of "deplatform[ing]" is such a funny one: in any other era, we'd call withholding one's business a "boycott."

But the history of the word "boycott" in the US has a distinctly anti-racial hue, and people who yammer about deplatforming seem to take extreme pains to avoid any comparison between today's boycotts and those good old lunch counters.
Is he not free to do that? I mean you can agree with it or not but how is that not a perfectly valid thing for a private individual to do? I don't have a philosophical objection to this.

Young is saying "I have some number of people who listen to my content and if you want to distribute my content you have to do this thing". Spotify said "no thank you". Where's the problem?
> No reason they shouldn’t work everywhere.

No reason except the complexity of maintaining huge amounts of code to support dead processors and operating systems, or ones that are so rare that they might as well be dead.
> See also Apple's chargers. They don't come with the extension cord by default, just the "duckbill"

This seems to be also local-specific; In Europe, the box contains both the extension cord and the "duckbill".
I'm not so sure. When, as currently, that wealth is generated based on the losses of speculators, the conned, or simply poorly informed, then I'd class Bankman-Fried into the robber-baron class who sought to cement their legacies with philanthropic endeavors instead of their ruthless practices. The means by which they accumulate their wealth are the lens through which we should view their "good works".
Drives me nuts. Having to rotate the entire monitor/computer to plug in a USB drive or SD card is such a bad experience.
> The fact that you left out the part of the sentence that says "The fsync() function is intended to..." suggests that you may be intentionally hiding this fact to support your point.

It's very difficult to read this accusation as having been made in good faith, since the person you're accusing of intentionally omitting part of a quote already quoted that very text in their previous comment:

>>>> The tl;dr (and blunt truth) is that Linux doesn't implement POSIX's semantics of fsync() correctly. The standard says "the fsync() function is intended to assure that after a system crash or other failure that all data up to the time of the fsync() call is recorded on the disk".
My biggest issue is that Spotify is prioritizing podcasts over music, and I'm not paying them for podcasts. I decided to switch to Tidal as they pay artists a much more fair share and focus on the music.
You can checkout the tutorials of EatTheBlocks, one of the biggest channels for Web3 development.

https://m.youtube.com/channel/UCZM8XQjNOyG2ElPpEUtNasA

Disclaimer: I am the creator of EatTheBlocks
"If you give me six lines written by the hand of the most honest of men, I will find something in them which will hang him."

Joni and Neil can do whatever they want and I respect that. What bothers me are all of the virtue signalers following them and getting rid of Spotify (or claiming to).

You will not be able to consume anything if you actually care about these standards. Everyone is shitty and people are wrong all the time. Good luck finding a blameless company to buy all your stuff from. Not to mention all of the musicians who have no doubt done bad things and made poor choices.

If you don't like Joe Rogan, don't listen to him. I don't see why people feel the need to fucking ban Spotify.
There’s a lot of that going on still - the maker / 3d printing folks are still beavering away, there’s plenty of open source creativity, etc. There are three big changes I think make it harder to see:

1. Google nuked Reader at the same time Facebook declared war on the open web. I follow this kind of stuff on blogs but a lot of people definitely shifted to social media.

2. The field is maturing in some ways, and a lot of open source energy moved into companies. That means that small projects are competing with Facebook for contributors and attention, and that there is less low-hanging fruit. A cool wearable hack now has to do something an Apple Watch, etc. doesn’t.

3. A lot of younger people are worried about things like climate change. Clean tech seems to have a lot of the people who a generation ago might have been doing web things.
It's a bit of tolerance paradox, in order to protect free speech we should avoid the free speech that want to censor others, otherwise we all lose the right. So of course pulling their music is their right, but it stops being acceptable when they pull their rights in order to prevent others from speaking. I am of the idea that we must tolerate free speech up to the point where this free speech is used to prevent others from speaking, that's the issue in this case

https://en.wikipedia.org/wiki/Paradox_of_tolerance

--
On the other hand what does this people want? Like I have 3 shots, I have done whatever the government and science asked, I did the first 2 booster and I've listened to the campaign where they said that it would lead us to be open and live again, then we went again in lockdown closed inside (I'm european), despite the vast majority having the vaccines (85%++), Then there was a third shot, now they're talking about the fourth one, meanwhile people still goes to ICU and people is still dying, and still getting infected (100k a day), I want to understand science and politicians, but at this point can we just like following blindly whatever is said and maybe start asking some questions? Can we start having some doubts about effectiveness of meds and/or measures or we just need to keep silent?
Apparently both are childhood polio survivors.
I view it as a freedom of speech issue because one side is advocating for another side to be silenced. These musicians aren’t just pulling their content - they’re trying to use power to shut someone else down. To me that is clearly a freedom of speech issue.