skysight-inc/HackerNews huggingface dataset:
I recently moved from the US to Berlin. I plan to return to the US.

Pros of Berlin:

- Good transport

- Bikeable

- Safe

- Cheaper than the big coastal cities in the US, with lower rent.

- Good clubbing (not my thing)

Cons of Berlin:

- Healthcare is inconvenient. Doctor's offices won't pick up the phone, and won't leave you on hold. You just have to go in person. Providers all work in small doctor-owned practices, and you get a referral runaround with huge wait times.

- The food in Germany is terrible. The quality of produce and other ingredients is very bad, and the restaurants are nothing special. One notable bright spot is the availability of vegetarian and vegan food. Also falafel and doner.

- The salaries are shockingly low. Really ask yourself if all the comforts of Europe are worth cutting your salary in 2 or 3, and that's before...

- Taxes. The top tax rate here is in the low-40s, comparable to the US, but unlike the US, the top tax bracket starts below $65k.

- Europe has an impending demographic crisis, and the social safety net they fund by plundering your paycheck probably won't be there for you when you retire.

- Stores in general suck. They have fewer, and worse products.

- Everyone still smokes here.
4.5% in December, which puts it on-par with 2017 and lower than 2016. U-6, which is probably a better measure of actual slack in the labor market, is lower than any time in recent history except q3/4 2019.
The FDA has decided that this a substance the needs restricting from general consumption for a reason wrong or no. Was that the right decision or wrong I don't know. But I have to assume they have some reason but it would be enough for me to take seriously the possible consequences of having a adverse reaction when dealing with the lives of OTHER PEOPLE if he had started his self experiment on his own time that would be one thing but he was treating other people and that makes this inexcusable. had he tried it in a safe controlled situation, then determined it to be safe and used it at work then I wouldn't care but he didn't. bottom line he put other people at risk.
I received a 1% raise at my current job. My coworkers who worked evenings and weekends received a "100% positive adjustment of their raise" (2%).
I just run Foobar under Wine. It works fine.
The problem is on the demand side. If consumers spend less (due to higher cost of borrowing), this makes it difficult for smaller businesses to survive or raise prices (while bigger businesses have access to cheap loans/can reduce workforce etc.).
>IMO official numbers dramatically increased

By dramatically increased you mean went from 1.8% during a pandemic when people were afraid to move around to 2.5% as things eased, well in line with historical levels.

I think the OP is much more accurate with the statement "the idea that employees are quitting in droves is exaggerated".

In fact, if you look back more than the year you picked, you'll see there was a huge drop, and the current blip is most likely those people feeling some relief from the pandemic. The rates are no where near out of line historically.

Here's historical data graphed for all 4 regions you listed.

https://fred.stlouisfed.org/series/JTS00MWQUR

https://fred.stlouisfed.org/series/JTS00SOQUR

https://fred.stlouisfed.org/series/JTS00NEQUR

https://fred.stlouisfed.org/series/JTS00WEQUR
The researchers focused on a particular type of liver cancer (HCC) because of "lack of effective treatments"

They focused on a particular protein molecule called CDK20 which appears to be important for development of HCC. You can think of it this way... "If CDK20 goes 'haywire', it can contribute to the development of HCC."

The idea is that if you can stop CDK20 from going haywire, perhaps you can slow/stop/prevent/reverse development of HCC.

Along those lines, if you can find a "small molecule" that stops CDK20 from going haywire, that small molecule could potentially serve as a medicine for treating HCC. "Small molecule" is a common pharma term for molecule that is smaller than most biological "macromolecules" like proteins. "Small molecule" is often used (roughly) interchangeably for a molecule that can be developed into an ingestible pill (or injected). "Small molecule" medicines are often relatively stable (i.e., can be stored for a long time without many restrictive storage conditions), cheap to manufacture (not always), etc.

These people used computational methods to create several candidate small molecules that might stop CDK20 from going haywire (the 'technical term here is that the small molecule inhibits CDK20. Some of this was done in conjunction with AlphaFold's predicted 3-D structure for CDK20.

But just because the computer says that your small molecule might inhibit CDK20, that doesn't mean that your small molecule will _actually_ inhibit CDK20 in the real world.

The first _true_ test is to make the small molecule and experimentally assess whether it inhibits CDK20.

One of their candidate small molecule compounds appears to inhibit CDK20.

That's one of the punch lines of the paper.

====================================

I don't like it when people are too negative about this stuff, but I'm going to be a little negative here.

Other than employing AlphaFold, this seems like pretty standard work for pharmaceutical development. I worked for a company doing structure-based drug design and the general concepts employed in this paper are not different from what wewe (and others) have been doing for a while.

They have a particular platform for finding these types of molecules and they would like to argue that their platform is unique and distinguishes itself from everybody else's platform.

I'm not saying that the candidate small molecule is "bad" or anything like that. It's definitely a promising lead and it needs to be pursued. But it's just a lead.

A lot of biotech / pharma involves hyping/selling your particular drug discovery platform and trying to convince people that your platform is the better/more efficient way of finding valuable drugs.

Just my 2 cents.
If anyone tells you they understand the brain - they are lying.

The only certainty we know is it’s located in your head and weighs a few pounds. That’s pretty much it.

The absolute best neuroscience program at the absolute best university would essentially read from an outdated curriculum (which means it’s from the last semester, in neuroscience that’s ancient history), supplemented with current studies, and you will be told that you will not be penalised for using answers from six months ago that have been invalidated now, and are absolutely wrong, but were the textbook dogma last semester.

Top program in America.
> the US Navy even let him on a multi-day tour of a nuclear submarine and tape classified information (later redacted)

They _paid_ him to tour it. It was a marketing event for the US Navy to drive recruitment.
I admit is possible, but the evidence so far makes it very unlikely. I think right now the efforts should be centered on controlling the pandemic, placing blames with inconclusive evidence only serves to politicize the issue, and politics can ruin everything they touch.

By all means the investigation should go on until there's concrete evidence, so any wrongdoing can be sanctioned. And I mean ALL wrongdoing, both from hypothetical leaks to domestic mishandling of public health.
This is old news. We’ve seen these exact SKUs compared before with better benchmarks. I was expecting a comparison to mobile Alder Lake at least.
In my darker moments I tend to agree with you here, but what I then realize is that it's monumentally difficult to get a land of 330m people to agree, and when you've got a group of people that large, the worst groups will just be bigger and meaner.

My worry for you is that this reaction is a visceral one, fundamentally rooted in a dislike for America's diversity.

It's a messy process, getting everyone to work together, and we're fucking it up pretty monumentally, but to call the effort a "shithole" seems like you'd prefer the US be less diverse? Fewer disagreements would arise, but at what cost?

Germany and Austria have... less than stellar records when it comes to human rights, and aren't exactly known for their exploding levels of diversity on a national level, so perhaps the "unity" you're experiencing came at a cost? Perhaps that very cost was something that disgusted you in the US?

I wonder how a Muslim would describe living in Vienna vs. living in, say, Chicago or DC.
I think it would be nice if English evolved to only ungendered pronouns. Eliminates accidental offense while also reducing everyone's cognitive load.

Also, you reminded me of a quote from yesterday: "The problem with defending the purity of the English language is that English is about as pure as a cribhouse whore."
Will World War III begin in cyberspace?
No, it's really not even arguable. Lots and lots of software is written in business contexts where the cost of developing reliable code is a lot more important than its performance. Not everything is a commercial product aimed at a wide audience.

What you're "sick of" is mostly irrelevant unless you represent a market that is willing to pay more for a more efficient product. I use commercial apps every day that clearly could work a lot better than they do. But... would I pay a lot for that? No. They are too small a factor in my workday.

Saving money is part of engineering too.
Apparently this isn't the only time he's done something that would concern your average bystander https://www.postcrescent.com/story/news/2018/12/20/reviewer-...
Have you not encountered classism in Germany? I am a fluent German speaker who lived in Erfurt, Berlin, Frankfurt and Munich and encountered similar amounts of racism and classism that I have seen in the USA, France and England. The attitudes of some people from the former West to those from the East are shocking. While in Erfurt, I saw the most horrific treatment of immigrants and refugees. I want to make sure that people understand that Germany is not some sort of magical place devoid of serious issues. The country is still suffering from the post-war division and unification, is battling a resurgent fascist political movement and the people are deeply divided over recent waves of refugees in addition to long-standing resentment against much earlier waves of immigration.
I agree, try Pax Syrah if you get a chance, it is the best one I have tasted:

https://www.paxwine.com/
There is a well researched documentary presented by Ray Mears entitled "The Real Heroes of Telemark" where he recreates parts of their journey which puts the feat of the resistence members into perspective.
Would anyone here want a cloud-hosted hosted version of node-red? Like a PaaS for node-red?
It would be really cool to see the service worker api supported in deno.
Pffft... that's nothing. Every time I check my spam folder, I find I've won the lottery, or been left millions of $$$ by a Nigerian prince.
Delomore: Discover Independent Online Shops
Portraits of (Debt) Relief
I do love living in New Orleans, either this or Brooklyn are the only real cities for me here. I need to be able to walk to a grocery store. I'm privileged to have lived here for 6 years, and the only reason I recently got an old truck, was to evacuate in case of a hurricane, and we didn't even evacuate during ida. The sidewalks are torn to shit, the streets are full of holes. I'm quite certain that the streets are never fixed because they wouldn't have enough cops to keep people from driving drunk. The city hall sign has been broken for 4 years, the lights don't work in some of the letters and it just reads "ity all" at night. It's illegal to be fully nude in SF these days, but NOLA still has a fully naked bike ride. This place can feel like burning man or joshua tree, but with toilets and electricity. Except for during hurricanes, then its exactly like burning man. I went to the bar next door during ida to find a couple fucking at the bar and open bottles of lube softly lit up with a dark orange glow from the 3 candles that dimly lit my favorite bartenders face as he asked about whether my house got badly damaged or not. The architecture is very old and very unique, actually its very european and feels quite distinct from the architecture in boston/nyc. I don't know a single person in tech here, everyone has some sort of creative endeavor and makes money through a hodge podge of sources. I live next to a 24 hour gay bar, and across the street from a supermarket, next to a vet, and caddy corner from a pharmacy. I never have a reason to leave my block, and this neighborhood boasts the most dense concentration of trans/queer people I've ever encountered.

The city boasts a strong spiritual history, which I sense, causes people to come here to either flourish, or get spit out. There's not much in the way of hiking/mountains around here, and the most beautiful natural environments are in the swamp amongst the gators and pelicans dancing through the soft and grassy patches of muddy land dotting the waters edge. There are no other cities I really like visiting within an hour. It's a bright blue dot in a fire-red state. Car-jackings are up 550% over last year, and the particular circumstances by which someone killed someone with a machete at the gas-station down the street from my house, I'm sorry to say, were unsurprising.

Having said that, I can't live the rest of my life not having *lived* outside of the US. I'll be moving to Berlin at some point, because that's the closest city that felt like it feels here. The food is cheaper, you can find Indian food, and there are more languages spoken. The government there doesn't feel like some morally corrupted festering cesspool of civil indifference and political myopia. Despite everything I love about this place, and that I'm quite certain I'll retire here, I'm eager to GTFO while I still feel young, to experience what its like to feel young in a place more free than the farce I've been raised to believe. I have friends in Berlin, and though German is pretty hard to speak well, I'm up for the challenge.
Please understand me. It's not a premature stoppage. If you are forcing me to be a slave, then fuck you for doing it, and any damage/death/loss suffered by others because of my non-compliance is on your hands, not mine.

I absolutely would rock up with a chair and sit watching. Hell, I'd bring popcorn.
But hoocoodanode that these immune escape variants would arise so quickly?
>this probably is no longer true

>most of the bigger companies have been moving to unlimited vacation

>concluded that employees granted unlimited vacation actually end up taking fewer days than if they are metered

It sounds to me like you just argued against yourself.
Wouldn't you want to not give the client any information about the correct answer? I would think you would want to have a `POST` command that gives you the encoding guesses if you truly want to keep it out of the browser.
My current Indie Hacking toolkit
Okay, good for you, that doesn't at all change my statement. A sitting president talking about "shit hole" countries doesn't equate to constant, enduring criticism from the rest of the world. Glad you can get one over on "other side" though. It's honestly people like you who drive the division that perpetuates the bipartisanship and make it even more difficult to pass legislature that could benefit the country. Before you criticize everyone and everything else, take a look at your own behavior and see if there's anything you can do to mitigate harm at your scale.
It feels like there’s enough interest in these comments to make it happen with some organization.
Using entropy for user-friendly strong passwords
All of those companies except Amazon have shipped ARM CPU cores fully designed in-house, yes. But all except Apple and NVIDIA have since completely dropped their custom core design, and NVIDIA goes back and forth.

Qualcomm did buy Nuvia though, so they might yet come back with something new.
> shortages as artificial

from a objective POV many but not all are mostly artificial, but not because of someone planing it or anything like that, but because of emergent behavior of our economical system and the complexity of supply chains.

Sadly all of this is very hard to change.

Especially with our world currently heading into a not so grate direction in nearly every sector and most countries...
The capital owning class are gunning to eliminate these salaries. "You will own nothing and be happy" is not something they just reserve for the lower classes. The future is hard to predict but don't rule out these outrageous salaries being gone in a decade or two and the market being much more middle/lower middle class type jobs.
YouTube CEO hints at potential NFT features
200% go: Vugu framework for go is 100% go on backend, 100% go on frontend
But you can't get faster hardware cheaper anymore. Not naively faster hardware anyways. You are getting more and more optimization opportunities nowadays though. Vectorize your code, offload some work to the GPU or one of the countless other accelerators that are present on modern SOC, change your I/O stack so you can utilize SSDs efficiently, etc. I think it's a matter of time until someone puts FPGA onto mainstream SOC, and the gap between efficient and mainstream software will only widen from that point.
If you're not lucky enough to be among the privileged, moving to Europe is impossible unless you have inherited citizenship (which is itself another kind of privilege).
> Forget pizza or Mexican food exists

Italian Pizza in London is better than in all of the US maybe bar Manhattan (unless you want deep-dish "pizza"). Same for all Asian food from Indian/Chinese/Thai/Vietnamese. You are right for Mexican food though.
Perhaps it is the trauma of non-consensual changes in software and especially user interfaces that we are forced to deal with regularly?
Or stay in it when it became clearly asymmetric.

I think the hopes were that China would benefit from trade and developed its own industries in a largely decentralized fashion (which happened). What didn’t follow was the assumption that this would cause them to become less authoritarian and more democratic.

Quite the gamble in the end; I don’t think those responsible over many decades realized what the consequences would be for getting this wrong. They all were championed by equally blind stock-market driven CEOs who wanted cheap labor, low/no environmental laws, no unions, a helpful and competent government, and new large markets who didn’t already have lots of stuff.

The US has gotten terrible at long term vision, while China has nothing but long term vision and long term memory.
Researchers Build AI That Builds AI
Can an iPhone detect other people's AirTags? What about an iPad? How do I do that?
> The Opportunity rover had a "90-day" expected lifetime and lived until 15 years old. It's great that Ariane performed superbly but this "doubling" calculation is pretty silly.

Yeah, no. JWST has a limited lifetime because of the finite fuel, that's completely different from building a machine for a purpose and the machine not falling apart at the end of the initial mission.

When people say Ariane doubled the lifetime of JWST, they mean Ariane performed much better than the allowed margins, thus pushing the fuel efficiency to its limits.

Think this, a Toyota has a lifetime of 100K miles but many get 200K out of it. That's completely different from achieving 80mpg on a car rated 40mpg.

When someone tells you that they are driving so precisely that they are getting twice the milage, is it appropriate to say "So what, my car was supposed to last 100K miles but lasted 200K"?

I think, no.
> I figured the pandemic cleared out most of the small businesses that would have failed within five years anyway

PPP and SBA loans kept these companies alive. The bill hasn't come due yet. This is what people don't understand.
I think this is kinda wishful thinking, tbh.

The labor market was pretty tight before the pandemic and has just become even tighter. Americans are less supportive of permissive immigration policies, birth rates are falling precipitously which means there is no end in sight. So companies which figure out how to do remote right (rather than accept is as a temporary adjustments) will have the edge as they can access a broader labor market (entire NA plus EU, maybe others if they can figure out time zones and outsourcing).
> I wonder if the author would be open to making e.g. the car data available?

Here you go:

- The stabilized frames out of blender (with 4 blurry frames in a separate folder): https://breaking.systems/plate_frames_sorted.zip

- The original video in case you'd like to improve the stabilization as well: https://breaking.systems/plate_vid_orig.mp4

Would love to hear back in case you'll tackle it!
Not to be offensive but this article made me feel dumber just reading it. THE MARTIAN isn't enough to inspire people to pursue science? Why? Because it uses clever ideas to "work the problem"? I'm not sure about his background but that is pretty much the only way to solve problems in the real world. Servers down you "work the problem", a researcher who doesn't understand why data looks like it does - "work the problem", trapped on Mars - "work the problem". Then he talks about reality and how Sci-Fi doesn't match up with reality!?

Including political realities is absolutely important when designing technology to solve large scale problems. Acting like SciFi (Andy Weir, Star Trek, and Neil Stephenson are all good examples) doesn't address that is a shitty shallow analysis. The Martian, is mostly an adventure story but Project Hail Mary deals with the political reality heavily and TNG talked about political reality and social issues and in fact the best episodes revolved around that. As someone that is an engineer, a life long SciFi fan, and am studying to change careers as a scientist (Biology/Data Science) this article reads seems pretty terrible as analysis/criticism of Sci-Fi like someone that has never actually built anything.
What was the guy who put up the fence thinking? Maybe he was thinking of someone else who put up a fence, who also thought: "What was the guy who put up the fence thinking? Maybe he was thinking of someone else who put up a fence, who also thought: ..."
And I know lot of people still living with their parents - especially in Southern European countries.
HN hug!
I am an immigrant from Albania. American bombs ended the Kosovo genocide. I have reasons to be grateful for this military and I can be upset and disappointed in it at the same time.

I did not say America is wonderful. I don't know why you even quoted that word, when it did not appear in my post. I claimed American taxpayers protect Australia's sovereignty. Obviously your state can do better things with its budget when its defense is bankrolled by someone else. I do not care where you live, your quality of life would plummet if the prospect of being invaded by Russia or China was a real one, a prospect you are protected from through American military supremacy. See Ukraine.
The post was not written by me, I just copied the title in the linked post.
I’m porting the TypeScript type checker tsc to Go
I think it's cheekier than that. It's a deliberate attempt to watch people miss points, argue, and split hairs over the mildest of mild rules of thumb.
I was hopeful WebAssembly will speed up the web. What's missing? Native Browser APIs? Native IO Apis?

Let's say I want to interactively plot some complicated function without slowing down the rest. Can I do this in WebAssembly now?