skysight-inc/HackerNews huggingface dataset:
Is is often the case... [in mice]

The team anesthetized mice, perfused sucrose or sucralose directly into their guts, and then analyzed the response of neurons that make up the vagus nerve using calcium imaging. On average, 40.7 percent responded to sucrose only, 22.2 percent to sucralose only, and the remainder to neither stimulus, explaining how the vagus nerve is able to react differently to the two substances.
I wonder if this is where the "red clay clods" from Stuart Smith's Rivers of Light came from, since pretty much anything in that game seems to be based on ancient history and/or mythology.
Show HN: Insta – an enjoyable snapshot testing tool for Rust
A topic begins to become interesting when there is an "it's not possible" answer and a "oh yea, here is an example of your question" style answer, especially when they are both quite convincing answers!

I think it depends on where you studied it. I know nothing about Industrial Engineering, but when I typed "Industrial Engineering" bachelor into google, the University of Eindhoven popped up and I wouldn't call it math-heavy [1]. So I wonder which Industrial Engineering program you're talking about. The program does look interesting, but I don't think I could commit to this particular one (I am searching for a program allows for self-studying, either formally or informally by being able to skip a lot of stuff).

[1] It is by no means low on math though: https://assets.studiegids.tue.nl/fileadmin/content/Faculteit...
Remarkable research by Benjamin Hardy on the impact our environment has on the body/mind/spirit.

Rotate your environments-getting out of your rut by literally changing your physical surroundings throughout the day or week.

> https://www.goodreads.com/en/book/show/35604684-willpower-do...
Reminiscent of Galettes in Haiti, which is still common practice.

https://en.m.wikipedia.org/wiki/Mud_cookie
Yes they dump.. and then some hype brings people back and it swings another 80% one way or another. It almost seems pointless to track.
I’m also curious how modern languages compare to older variants. Even modern English to Shakespeare stuff.

I think to measure efficiency of a written language, you’d have to time how long it takes people to read it (and correctly answer some questions to prove they understood it).
Good point. Because the set of possible guesses is constrained, the totally general solution needs to take future guesses into account. There doesn't seem to be a way to find the optimal guess other than searching the whole game tree (which it looks like someone in another comment did).
Thanks for this, super detailed. Which wallet would you recommend? I want to just securely store my Bitcoin, not on an exchange, but I'm happy to buy it there to start with.
1. I use both WhatsApp and telegram with different people, a lot of people I know do this.

2. I meant I don't use Facebook Messenger or website chat. I know tech speaking WhatsApp now use same backend, I started using WhatsApp well before Facebook acquisition.

Sorry but you are really just being pedantic.
Sorry, I realized after posting that I should have said "share-nothing by default". There are ways to share memory with a worker, but it's explicit and opt-in via a dedicated API. It's not like in Python where you can arbitrarily change global state from any thread.
Show HN: I built a Hacker News for newsletters
I think of how the Space Shuttle had 4 computers running the same software and a backup computer running a simpler implementation of the control program.

The flight control systems of civil aircraft like the A320 has failback modes to handle hardware failures such as a failed angle-of-attack sensor

https://a320podcast.libsyn.com/flight-control-laws

The 737 MAX crashed because it didn't have fallback modes.

Engine Control Units in automobiles also have fallback modes. You shouldn't get stuck just because an oxygen sensor failed, even though that means the car will have trouble balancing clean emissions, performance and fuel efficiency.
I have a celeron pc with xp nearby!
Do you know what language the libraries are written for?
> Men and women can't be friends. Eventually the sex gets in the way.

I have MANY female friends who have been in my life for decades and I have zero sexual attraction to them (and likewise they have zero sexual attraction to me). I have no idea why people perpetuate this stereotype that women and men cannot be friends. It's entirely possible to separate the people who you want to be friends with and the people you are sexually attracted to. Obviously, the women who I am sexually attracted to I don't attempt to be good friends with for fear of risking my long term relationship.
>1) To apply for Watson access you needed to show C-level approval, so our CEO put his name and phone number on the application (trying Watson was somewhat his idea). A few months later, an IBM marketing team called HIS CELL and asked for ME. Imagine how it felt to have the CEO walk up to me, deadpan hand me his personal iphone and say "It's for you."..

This sounds like the biggest power move you could ever pull.
Which wallet do you use?
Pretty sure that’s what I said.
This sounds great on the first glance, I wonder: how is it taken in practice? I guess it is slightly better than clear refusal...
I built this a while back already but I figured I might show this to hackernews and solicit some feedback. It's basically a Rust implementation of an approval / snapshot testing framework.

It makes it possible to make assertions where the comparison value is managed by insta automatically. When the reference value changes it gives you a diff of the changes and you can approve of it.

This is particularly useful if you have a lot of generated test cases. For instance we're using it for asserting how the sentry symbolication system symbolizes results.

There is also a Visual Studio Code extension that makes it possible to manage snapshots from VSCode: https://marketplace.visualstudio.com/items?itemName=mitsuhik...
I once forgot my gmail password. There was no way for me to recover it. Eventually I found it after 6 months, but it was a very difficult 6 months. bank emails, work emails, etc were in the google 7th circle of hell, and there was nothing I could do. I don't have any good advice for you really except is there a way you could vpn to a location closer to where you typically access gmail?
I can't see the use of this in almost any code. All of the "bad" examples they gave just seemed perfectly fine, and if they make sense to the user of the library, there's no reason to disallow them.

There are rare cases that actually call for keyword-only and (even more rarely) positional-only arguments, but unless they are required for your usecase, please do not enforce arbitrary argument types on your users.
Immutability doesn't really solve everything. It provides a cleaner path for retries for writes, but still doesn't handle situations where reads fail.

I think the conclusion in the article ("don't do fallback") is misguided. Fallback code is sketchy, but sometimes it is worth it to take the time to write well-audited, well-tested fallback code to ensure a system which has high availability requirements can survive dependencies which are less reliable.
Hoping to see a BLAKE3 implementation in whatever library is necessary for distros like Arch to verify package checksums soon.
I hope not for lack of other options.
Brain of a White-Collar Worker (2007)
> In the last roughly 10 years, Google, Instagram, Dropbox, Facebook, and reddit all invested a lot of time into trying to make Python fast and was pushed away with harsh no's. There are dozens of forks and branches with basic optimizations that were rejected.

Is that true?

The talk you link was about a very secretive fork of Python that Instagram was very adamant about not open sourcing until very recently (in fact it's not clear that what's open sourced is their full project).

Other than that until recently all I've ever seen is either breaking the C-API or no clear commitment from the maintainers that this was a sustained effort to support and not just a drive-by complicated patch.

In more recent times we have cinder, pyjion, pyston, and others. And CPython Devs are up-streaming either their work or their general approach.
Considerably better
Thats weird, because off-road busses have been operating in NZ for at least 30 years.

eg the farewell spit tourist operation

https://www.google.com/search?q=farewell+spit+bus&tbm=isch

I recall these used to be built on unimog bodies, so incredibly capable, but underused/expensive.

And various truck-based busses used for skiing in winter, and adventure tourism in summer

eg https://queenstownweddings.org/listing/nz-ski-bus-charters-2...
Ugh yeah, I hope this eventually happens.

If some fork of python that has no GIL becomes popular, another python 3 situation could emerge with the community splitting.

This "reference implementation should be simple and easy to read" is the dumbest part of python, unnecessarily holding it back imo.
Read, take a class at community college, and/or invest in a nice pair of large binoculars and tripod. They are more convenient than a telescope, cheaper when starting out. Join a local astro club, where you'll get to try out the "big guns" from other enthusiasts who can also give advice.
I'm not the parent commenter, but I studied biochemistry and find abiogenesis to be a particularly fascinating topic, so I'll take a crack at answering your questions:

> How far down does this apply? E.g., do amino acids come basically for free in the same way?

Broadly, I think it is fair to say that many molecules that we associate with biological processes (e.g. amino acids, nucleotides, simple alcohols, etc.) do come "for free" in the sense that there are known pathways for these molecules to be produced in the absence of living organisms. The Miller-Urey experiment is probably the most well-known proof of concept of this idea, though it's debated how well the experimental conditions correspond with "the real world."

> ... [W]hat's the bootstrapping process like, and how random is it?

If I understand you correctly, here you're asking "what does it take to get from prebiotic organic molecules to living organisms?" And that is a fascinating question that has, to my mind, several possible answers, though ultimately I think the answer is "we don't know."

One very suggestive paper I read describes the bootstrapping process as a "surface metabolism" [1] that succeeds through several epochs before eventually producing free-floating lipid-membrane-enclosed micelles containing complex organic molecules and a rudimentary metabolism - i.e. protocells.

However, the IIRC paper falls short of explaining how these protocells can then start to independently reproduce. One hypothesis I recall from David Deamer is that hydration/dehydration cycles in shallow pools promote complex organization of simpler protomolecules into structures we typically associate with living organisms [2]; in other words, given the protobiomolecules mentioned above, certain environmental conditions encourage [proto]cell formation.

So, to answer your question (I think), there are many good candidates for the "bootstrapping process" and while there is randomness involved, it turns out that certain environmental conditions that were present on the early Earth (as well as currently!) tended to promote complex molecular formation.

> How many steps do you have to take from self replication to functional cells?

Not many; I would say that if you have something that looks like a cell and reproduces itself, it's a "functional cell." Personally, I think from that point we are at an, if not the, "origin of life," and understand in broad strokes "what happens next" - ever-more-refined single-celled organisms, multi-cell aggregates becoming "true" multi-celled organisms, and so on.

Let me know if you're curious about any other aspect of this topic and I'll try to provide more info!

[1] https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC373159/

[2] https://www.liebertpub.com/doi/10.1089/ast.2019.2045
Taleb basically always sounds like that. He's angry and he thinks everyone else is stupid. I find it a bit of a turn off but it seems to have worked out for him.
Similar "problem" here.

I got raised by my mother alone. My father left when I was 5 and even before, he was at work all day anyway. Then I got a step dad when I was 13, but most of my formative years I was raised by my mother alone. I imagine that's one reason for this problem.

I only have interest in female friends and basically went all polyamory because of that. This way the feelings problem isn't a problem anymore.

I had the experience that many people would somehow value me as a good friend of them, but I only see them only as an acquaintance.
First, don't feel like you traded serious relationships for academia. A lot of younger relationships don't work because the people aren't grown up enough. (For me, I had to become less of an arrogant jerk. That took a bit of time.) So don't kick yourself, looking back and saying "I could have dated..." You could have, and you might have enjoyed it, but put your mental energy into chasing the relationship you're in now.

In fact, don't look back much. You want to learn from past mistakes, sure. But if you've had a car accident, and as you drive off you're staring in the rear-view mirror at the accident, you're going to have another one, because your attention is on the accident, not on your driving. Learn from the past, but put most of your attention on what you're doing now.

You sound unfulfilled in academia. It often is unfulfilling. But so is working in industry. Fulfillment isn't going to come from either of those places; both are ultimately empty. But fulfillment might come from your relationship. Don't sacrifice that for either a degree or a job. (Personally, I'd say that even a relationship isn't ultimately enough; real fulfillment comes from knowing God.)

But you didn't actually say that you were unfulfilled, you said that you'd never be appreciated. Do you need to be? You are unlikely to be, either in academia or in industry. (Again, though, you might be in your relationship.)

Oh, and in your title you said "depression". You're in grad school. It's amazing how high a percentage of grad students suffer from depression - like, 60+%. The depression isn't necessarily telling you that there's something wrong with you, or that you don't belong in academia. It's telling you that there's something fundamentally wrong with grad school. (Which, if you can't change it, may be telling you that academia isn't where you should be.)

No real conclusions, just some thoughts that you may or may not find useful...
Stallman and FSF predicted this decades ago, but they failed to foresee not many people really care about being able to control their computers as much as big expensive hardware purchases like vehicles. DRM and general lack of free-software rights is the root-cause.
Issues:

Study 1 is across college-aged kids who are willing to participate in a psych study (in exchange for partial course credit or a lottery
entry for a $40 gift card, IE they're psych students). Unclear why you'd generalize a study run across a single college, within a group of students who self-selected into your course, and draw conclusions about all men and women. In addition, you're asking people what they prefer in their friends; not measuring it.

Study 2 isn't controlling for variance in the underlying traits between the genders. All it shows is that if your best friend is male, they're likely to have different traits than if they're female. It does not show that you picked male/female friends because of those traits. So for example, when they find "men's same-sex best friends were more likely to possess qualities of physical strength", what they've discovered is not that men look for physically strong friends, but that men are usually stronger than women.

Study 3 is across people working on Mechanical Turk. That already skews your sample. It asks participants to weight the relative aspects of what they look for in a friend. But this relies on the participant being aware of what they look for. If someone thinks that they don't need emotional comfort from friends, they'll say so, but it doesn't mean that it's true.

tl;dr: This study is methodologically flawed, and the conclusions it draws are mostly to be splashy and show up in random articles. It'll be shared because people resonate with its conclusion and not because it contains robust evidence of its conclusion.
I think you're right according to levels.fyi: https://www.levels.fyi/?compare=Goldman%20Sachs,Google,Faceb...

I got an interview request from GS for a "Managing Director" position and I was really confused at first because I'm clearly in the IC track. From what I could find it seems equivalent to a Staff role.
I agree with you say verisimi. Pretty sad.
As much as I hate trial lawyers, as of today we would not be better off without them. Bad corporations will squeeze money out of you as much as they can.
The solver is playing in "hard" mode, where any yellow/green letters must be used in further guesses
Ah yes, reality is inconvenient when you are trying to solve an issue from your armchair with the mental hardware of a midwit.
Ans: When it comes to manufacturing billions of doses, Ward adds, companies need fast-track regulatory commitments from the Food and Drug Administration and a guarantee from governments prepared to buy them.

Basically the FDA is being risk adverse. And the government won't commit to funding. Bonus the FDA being risk adverse is why pediatric vaccines aren't available.
The data clearly show a significant overhead for integer bounds checks. https://danluu.com/integer-overflow/

At scale this adds up to millions of dollars. It would be a deal breaker for switching to Rust for many organizations. That's why bounds checks in release mode are not the default.
If you say anything, it's possible that you would be ending your career. If you do, it is likely that you will be hunting for a new job (and your reputation as a bigot may follow you unless you move to a new industry, and even then depending on how profile your departure is).

This has become a common practice in the tech industry, and unquestioned support is expected at a minimum. If you have non-standard hardware on your body, then you can push back a little, but if not then you best stay quiet. If you continue to push back, depending on how hard you push what you can expect is many awkward conversations, decreasing performance reviews, and career stagnation. Getting to the "next step in the ladder" typically requires you to demonstrate your willingness to implement these policies, let alone simply allowing them.

You also need to be careful what you say, as anything you put in writing could come back (potentially out of context) to bite you. You may be recorded a few times in private IRL meetings, so remember that just because it's in a closed-door meeting doesn't mean it is private. I know this sounds paranoid, but I've watched a friend of mine in SV go through this very thing. This is a man who spends his free time volunteering to help underprivileged students learn to code and build robots with raspberry pis in his spare time. I've known him for years and he is not a chauvinist, he just doesn't think it's right to discriminate based on immutable characteristics.

I wouldn't worry about any legal liability on your part. IANAL but I'm certain many good lawyers have reviewed the policy as it's fairly common now. I also can't imagine anyone being sued/prosecuted for giving females preference in the tech industry.
Add this one to the list: https://en.wikipedia.org/wiki/Phoenix_pay_system
I’m a straight man, one of my best friends is a straight woman, and we’ve known each other for 20 years. By best friend, I mean we talk almost daily, go to each other for advice and emotional support, and are comfortable discussing very intimate details about our personal lives.

The idea of a sexual relationship with her is just gross, though, in the “I’m screwing my sister” sort of way.
Hey, I feel vaguely similar, although on a much milder basis. I go from starry eyed to quite a bit of regret and contempt. I am not happy with that, and I am working on it, at the same time it is what it is. I used to be simply starry eyed.

While I am no therapist, I know a thing or two about sacrifice, perhaps less than you, but enough to perhaps have a fun (or interesting/stimulating) chat about it.

If you're up for a Google Meet, feel free to email me (see my profile).
I'm not aware of any instances of this but the solution is pretty simple. It's not dis similar at all to the current web. At the end of the day, any node that faces the public is a web server that is serving content, whether it's backed by a Blockchain or not. If it transmits a mentioned "illegal content" then it must cease to do so just like any other web server.

What is the practical solution? Clean nodes. If such web server is in a jurisdiction of said illegal content, it must run a clean node that specifically filters such content to the web. This technology exists today, it's called "moderation", it's just that the backend is a MySQL database, not a blockchain.
Strange, the Expo line usually runs quite late, unless you are drinking until last call. Generally, I think across all LA Metro train lines, they stop running 1am-4am.
> kids-only "school routes" for a lot of public busses when public transit doesn't align

The same vehicles and probably the same drivers (or a subset) are used, which should cost less.

I think it's only the USA and Canada that have a separate design of vehicle for school buses.

(Why are American school buses such an old design? E.g. this [1], which is the first modern one listed on the Wikipedia School Bus article, has a high enough cab that it needs loads of mirrors for the driver to see around, and has a high floor (so several steps to get in).

A typical bus used in European cities is this Mercedes [2]. The driver has a better view, there is only the one step to get in, and it can be lowered [3].)

[1] https://en.wikipedia.org/wiki/Thomas_Saf-T-Liner_C2

[2] https://en.wikipedia.org/wiki/Mercedes-Benz_Citaro

[3] https://www.youtube.com/watch?v=dr5BSIFB_GY
If you live in the USA you probably never will be. Without a social safety net you are never free to explore and fail because it’s a long way down and the fall will maim you if it doesn’t kill.
We have no evidence that we are randomly distributed over some population of universes, but that doesn't stop misguided philosophers from assuming that. I didn't assert infinite universes; rather the opposite. It's reasoning like this that is asserting other universes. One thing is certain; ours is super weird and has definitely produced self-aware apes in a long series of evolutionary accidents on a single planet.

What's more interesting is whether our universe can be described by finite information (closed formulae or not, even a stupidly huge but finite trace of all quantum events would suffice). If it's finite information then its description is encoded in every transcendental number in mathematics--which is an infinite number, including the number pi.

Don't trifle with infinity. I wasn't.
Any idiot who tinkers with cars can flash custom firmware on their car's ECU without a problem, and cars can very easily maim or kill users and the people around them. I don't buy this argument.
From an academic perspective, it's no problem as the primary audience are other researchers where the limitations are a given.

However, I posted the details from the study's design for the readers of Hacker News, who might assume that the study is generalizable to the broader U.S. population, especially since only the abstract is available for most users who see the link.