skysight-inc/HackerNews huggingface dataset:
As other commenters point out, this "analysis" is a joke. An E()-value of 282 says we would expect a match of this short sequence against a completely random library of the same size 282 times. Even with BLASTp's parameter correction for short sequences, NO short sequence will generate a statistically significant score.

Let's try a more sensible approach. Let's see how often the sequence occurs in other databases. The author's 1/20^6 (1/64,000,000) probability calculation omits the fact that every database search considers many millions of possible alignments (a crude calculation would be 6 * the database length, or 6 * 1.6E7/20^6 ~ 10000E6/64E6 = 156 times by chance), and we're shown that in a 5,000,000 protein/1.6E7 residue database, 100% matches are seen several dozens of times, as expected.

How about other protein sets? Search the human protein set (19,000 proteins), there are no 6 amino acid 100% identical matches. The best matches are 100% of 5 residues, or 83% identity over 6 (with an E()-value of 22).

How many proteins do we need to search to find an exact full-length match? (we have dozens of matches in a 5,000,000 viral protein database. and none in 19,000). If you search all the NCBI landmark sequences (~500,000, non-redundant), there are 3 identical matches (E()-value: ~44) in Drosophila, Corn, and Strep. pneumoniae. So this sequence is not very special -- as the E()-value statistics indicate, it happens all the time by chance. (If it happens 3 times in a 500,000 sequence non-redundant database by chance, we would expect it to happen 30-100's of times in a 5,000,000 redundant viral database by chance, which is what we see.)

Six amino acid non-significant matches are evidence that properly done statistics are accurate, and pretty much nothing else.
Not quite. 80% of the energy in D-T fusion reactions are released as neutron energy. I sure hope most of that will be used for generating electrical power rather than breeding tritium... :) The dpa rates and helium embrittlement are way higher for fusion and fast fission reactors than for thermal fission reactors. See Figure 3 and 5 of https://www.annualreviews.org/doi/abs/10.1146/annurev-matsci...
I just watch the NFL, but I get the majority of games each season for free over-the-air in HD with a $20 antenna.
There are at least two tests for it, or at least there were in the mid 1990s. One's a quick clinical test with lots of false negatives than can be done in-office but unless it's a campus healthcare clinic at a university they probably don't bother. The other is a more sensitive lab test that takes a few days. If you're having a really serious set of symptoms they may test to confirm it's not something else. If it's a minor case, two weeks of bedrest fix a lot of issues in a young adult and you do probably already have it anyway.
I went back to staff engineer after trying to make it as a teacher.

Teaching is not a dynamic career, at least not for me, the one full time CS teacher at the small school I was at. There’s a little more data to it though: based on the attitudes of a large enough minority of staff and majority of leadership, it wasn’t a career where one could take risks and reap rewards. Not with the amount of social capital I brought to the role, at least.

I had hoped that as a CS teacher with a huge amount of industry background I would be able to make an impact outside of my classes. The quality of the school’s IT meant that, with the right leadership, the IT team should have been crying for out something new. They certainly had the funding for it — external funding from a high net worth parent — but the will to do something novel and interesting just wasn’t there. In the end I was kept at arms length from any of the new hotness projects, which themselves were very staid and notable only in that they made enormous spends on high value equipment rather than doing anything valuable with people — the staff and pupils.

One or two individuals attached to those projects should hopefully still be able to make an impact, despite the lethargy of the old guard wanting their thumbs in the pie and their unending ability to extinguish any dynamism.

(Procurement of new hardware, for example, had to be signed off on by IT. They were the blockers to one very cool new piece of hardware but they weren’t incentivised to do anything other than get everyone to agree they were the gatekeepers. They weren’t incentivised to open the actual gates at any kind of speed.)

I’m much happier back in industry. The true joy of tech is that the business’s primary asset is the codebase, the diffs to the codebase, and the engineers driving them. We can gather around the machine and tangibly make it better through generating intellectual property using our keyboards.

With teaching, the main way of making any kind of progress like that was in the classroom. By its very nature, that is lonely work. You teach solo. You mark solo. There’s no collaboration at all with peers and 80% of the job ends up being behaviour management rather than content creation and delivery.

Interestingly, the most peer collaboration I did as a teacher — which as I said, wasn’t very much — was very much about behaviour management of the kids. That part was cool, but it’s nothing compared to churning out diffs and, moreover, collaborating with other devs to encourage and develop them to churn out their own impactful diffs.

When I put it like that, I guess I’m still a teacher but now I get paid 10x for doing it with young adults instead of old kids. (By which I mean both the high school pupils and the handful of childishly petty staff who sullied my experience.)
That too, which is why we need to get crypto-mining off-planet, stat!
there's also ns.reddit.com that appears to be the same as old.reddit.com
Glad to see someone with a positive outlook.
> How's the price of house even mattered all their life?

Depends on the way the financial sector works where they live; in the US, if they ever applied for credit for anything while owning the house, it, and their debt:asset ratio, probably would have played a role in the terms they were offered, and that may have been largely transparent to them, because a lot of the information flow supporting that decision doesn't go through the people applying.
I was answering the question. What other ways can you achieve innovation without limiting regulation? If the NRC is unwilling to budge, and they hold the keys to the castle, there’s no solution.
> and was paid significantly less than my team mates who were more junior than I was

This is the kind of thing that any company doing this should be named, shamed and blocklisted.

There is no reason other than greed that a higher ranking employee shouldn't make at least as much as a lower ranking employee in total compensation. "Person was hired earlier and is okay with the lower wage" is, frankly, a reflection of a company hating their employees. It's a shame and an embarrassment.
I know I've got it good, and I don't take it for granted. One significant downside of being at a small company is that we don't have FAANG salaries. I'll absolutely settle for a really good salary plus an amazing work environment over ludicrous salary with the downsides of working for a giant corporation.
> just family pics, announcements, etc

Easy to do with email. Why do you need Facebook at all if those are your objectives?
2 or 3 years fixed interest terms are common and 1-5 years fixed terms are available. FI loans cannot be closed early without incurring some penalties (economic costs). But the most popular loans are what are called Variable Rate Loan over 25-30 years. The interest rate can vary through the term of the loan based on the interest rate movement by Reserve Bank of Australia. These loans can be fully paid anytime. Split loans are common too where a portion is fixed and the other portion is variable. Another unique feature in Australia for Variable rate loans is a so called offset account. This is a normal bank account attached to the loan and any money here offsets the loan balance. So people can save any extra money over the minimum repayment in an offset account to reduce interest payment (as it is calculated on the difference of loan - offset). The money from offset account though can be withdrawn anytime providing tremendous flexibility.
It goes back a long ways and it stems from very minimalist only free software linux communities. Many of these communities I've been privy to for 15+ years take pride in running in the smallest memory footprint, are anti-Java, anti-javascript, anti-Poettering (systemd as a backdoor), etc. and this is the premise of it. This community will get very mad at you for suggesting to add in those things that they deeply hate, i.e., javascript or non-free software blobs.
Show HN: Automated analysis of open source ecosystems based on Lists
Would you please stop posting flamewar comments to HN? You've been doing it repeatedly, and we've already asked you more than once to stop.

https://news.ycombinator.com/newsguidelines.html
I think a version of this is what the internet needs but using headless browsers from the client and with a somewhat-centrally curated set of scraper "recipes" if you will. Basically a community curated/updated set of scraper logic per site (yes some trust is required) that essentially provides JSON data and/or APIs based on the site. Even just a neutered HTML equivalent of sites (e.g. amp w/out the Google and ads stuff) would be good.

Since it is all client side, it can be dubbed a "browser" not a "scraper" and one might hope popularity is high enough that active blocking of it is blatantly user hostile. Granted one hopes that, like EasyList and uBO and others have shown, the community can outpace site owners. Not appearing headless (tunneling captchas, literal mousemove events in pseudo-random human-like ways, etc) should be doable.

It's something I have thought about and once dubbed "recapitate" (https://github.com/cretz/software-ideas/issues/82) and plan to revisit. I have seen many versions of this attempted. We need to encourage shared data extraction tools.
Early on one news site I followed kept a long list of all the vaccine candidates that were under development, and there were impressively many. Even the Kazakh Biosafety Research Institute had one.

That kind of worried me. Because even if you think sars-cov-2 is completely natural (and I have no problem accepting that position), have you thought about how many groups around would still have the capacity to make such a virus, if they wanted to?

Even just the fact that "some people believe the virus was made in a lab" can be dangerous. Because what if, say, Kazakhstan's dictator-emeritus Nursultan Nazarbayev believed it? How far-fetched is it that he, or someone like him even in the more nominally democratic parts of the world, would decide, "they fired the first shot, we can't allow there to be a bioweapon gap!" and commandeer the institute to do "dual use" research?

It would be easy to excuse too. They could say, "we're just designing these powerful virus variants to have a vaccine ready in case someone else comes up with the same powerful virus variant", and it would be a reasonable argument, at least as arms race escalation arguments go.
what you conveniently left out was that its only less by $100B (also one time vs recurring). Secondly it happened at the hand of a republican president and the democrat had to clean up the mess made by republican as always. one more thing the bank bailout was absolutely necessary if you did not want economy to collapse into a depression but none of the conservatives ever talk about all the banking deregulation (like graham beach leahy & glass stegal) that actually led to the conditions where financial system became so fragile that it had to be bailed out. Also, Govt actually made money on the TARP bailout after the funds were mostly returned.
Microsoft Launches Inclusive Spelling Tool
I meant in regards to how long an employee works for an employer. That seems like it needs no government intervention.
Someone has been charged. You dont waste hacking talent like that.
So same as 2 shots...
"Netflix's subscriber growth slowed from a boom early in the COVID-19 pandemic but rebounded with help from global phenomenon "Squid Game," a dystopian thriller from South Korea released in September."

It is amazing that one big show can bring a significant number of subscribers in. Seems like most, if not all, services have at least one big hit, but it's never enough to get me to try. I want to see Ted Lasso, but it just doesn't seem worth signing up for yet another thing to just watch one show.
Oh, I agree. I don't like the printf/scanf-like approach to BER encoding. In fact, it's awful.

The point I was making is that code generation is not the only option for ASN.1 or any encoding.

Also, ASN.1 types map very well onto C (surprise):

- OCTET STRING -> struct with pointer and length in bytes

- BIT STRING -> struct with pointer and length in bits

- INTEGER (constrained) -> some stdint.h integer type

- INTEGER (unconstrained) -> struct with pointer to array of uint64_t, array element count, and boolean to indicate if signed or unsigned

- REAL -> double or some arbitrary precision real library's type

- most string types -> pointer to array of char, or counted byte string type

- SEQUENCE OF and SET OF -> struct with pointer to array and count of elements

- SEQUENCE and SET -> struct

- CHOICE -> struct with discriminant enum and union of alternatives

- tags -> ignore

- OPTIONAL -> pointer

- DEFAULT -> nothing special

- NULL -> int (whatever)

- BOOLEAN -> unsigned int, bool, maybe a bitfield of unsigned integer type so that all booleans can be compressed, etc.

- OBJECT IDENTIFIER and RELATIVE OBJECT IDENTIFIER -> struct with pointer to DER encoding, and length in bytes

- extensibility markers -> [hard to make this pithy, but it can be handled just fine]

That covers like 99% of it. Suffice it to say that there's a very natural mapping of most of ASN.1 onto C.

Things like classes and object sets aren't types but can guide the tooling to provide automatic encoding and decoding through open types (typed holes).

BTW, `SET` is silly. `SET OF` is only of interest if you have arrays where order doesn't matter and you want a canonical encoding, but since one should not depend on canonical encodings, `SET OF` is also silly. IMO both should be deprecated (they can't be removed, but hey).
Ask HN: Does anyone else time their checklists?
Does anyone time their checklists or have checklists that would benefit from a timer? I'm thinking of information like how long does a checklist step take, how long does the entire checklist typically take to complete, or when's the last time I did a checklist. I have two small examples in mind where this has been useful:

1. reviewing my finances—and making sure I don't miss any transactions

2. GTD weekly reviews—to make sure I make enough time for a review, especially if I'm not as consistent as I'd like to be

Very curious if anyone else finds it helpful to time their checklists. Or does it suffice to just do a checklist regardless of how long it takes?
NOx are formed from the atmospheric air during the combustion.
In my cursory encounters with numerology, I have learned that if you try enough hypotheses, something will always pop out. Could this be the case here too, or is the gun-smoke so thick that no cherry picking can explain it?

(eg https://i1.wp.com/www.ghgossip.com/wp-content/uploads/2020/0...)
Adding one more thing to my comment -- I think an important skill is the ability to put details in boxes and then kind of forget about them. Eg when thinking about a software system, being able to look at it with the appropriate "zoom level." The shape of the boxes, and how they relate to each other, are what you need to look at. Crucially, though, this doesn't mean details aren't important, it means they're not important _right now_. That's why I picked the analogy of the boxes; you will at some point need to open up the boxes again.

Or another way to try and explain it -- you can't keep everything in your mind's "RAM" -- when trying to think systematically, you need to offload the details onto disk for later retrieval. Don't throw them away! People who are "vision people" and brag about not sweating the details become really annoying to work with as a software engineer -- but you won't be able to grasp the system if your mental RAM is cluttered up with those details all the time.
For more on EBV, I've discussed it on my blog here: https://denovo.substack.com/p/epstein-barr-virus-more-maladi...

(It doesn't just cause MS!)
So, we have half a meter of lithium just sitting there, not contained in any structure?
Here's some footage of Monju - pretty scary: https://www.youtube.com/watch?v=DRJGHWbIxC0
Back in 1980s, there were proposals for a "chronic mononucleosis" or "chronic mononucleosis syndrome" as a diagnosis / standard disease. There were very comprehensive studies trying to investigate the patients who had chronic fatigue and other long lasting debilitating symptoms. After a good decade of studies, the research community found that this group of patients is very consistent (their complaints, symptoms, etiology), but failed to prove EBV as a cause (although the studies did not disprove it either) or at least come up with a clear serological diagnostic criteria. So, in 1990s they decided to define a generic Chronic Fatigue Syndrome (CFS) as a standardized disease. Other viruses and pathogens can cause CFS/ME and a broader definition would sometimes include even psychosomatic patients, so as a result CFS/ME has been quite discredited.

Diagnostic techniques evolved and research progressed. In the recent decade, new studies are very close to proving that EBV is indeed a likely cause of CFS/ME (well, one segment, as there are other causes too). Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912523/
> So, what do they need that extra money for?

FIRE. Money buys a lot beyond your monthly food and rent.

> I fall into the group where I could probably make more

If you don't know for sure it's also hard to judge if you're making the right decision. I also wouldn't risk a nice and stable situation for a +5%, but recent threads on HN have been mentioning way higher bumps lately, hence compensation #1 (again on HN, SV-centered etc.).

> there is risk with leaving (bad boss, toxic culture, too much work, etc)

The chance goes both ways though, there's also a chance you might end up at a better place on top of a better compensation. If you're risk-averse that might not be for you, but there's probably a compensation bump at which it makes sense even if you're risk-averse.
That's true, but I don't think most people would put, "the state sold the house my mom has lived in since 1972 and kept the proceeds" in the "downstream inconveniences" bucket. It's a pretty big deal! The whole point of getting approved for Medicaid is that you won't have to go broke paying for your healthcare (at which point you'd qualify for Medicaid, anyway).
That's the point of securitization, which is the point of the article. The banks aren't holding the mortgage. They immediately sell it off to some other financial institution who wants to buy what basically amounts to a homeowner bond that pays the prevailing interest rate. (There are some differences mentioned elsewhere in this thread, notably that the homeowner has an option to pre-pay, there's collateral that the mortgage holder can foreclose on, risk profiles are different for homeowners than corporations, etc.)

The bank doesn't care what interest rates are going to be next year, because they sell the mortgage now and collect the cash for it. The buyer cares, but the buyer is probably a hedge, pension, or sovereign wealth fund that in theory at least should be able to estimate & offset interest rate risk.

I wish the article went into more detail about exactly who the losers are in this system. I suspect that it's essentially a policy by the U.S. government to increase social stability (in the form of homeownership, stable residence, investment in communities) at the expense of holders of U.S. dollars and dollar-denominated assets (i.e. most of the rest of the world). In other words, it's transferring wealth from non-citizens in exchange for keeping citizens happy, which is a pretty typical government play. It also looks like the system is on the verge of collapsing, in the sense that it pumps up house prices and encourages artificially low interest rates and high inflation, and hence an increasing number of American renters are being caught on the wrong side of the equation.
I live in the US and I've always found the idea of a house as something that is supposed to appreciate in value to be odd. Sure, it's great for you if it does, but I really don't think it should be an expectation. The only issue I can see when it comes to the price is if you want to move out after just a few years but the value has fallen. Hard to buy a new place when you're still on the line to pay the mortgage for your old place even after selling it.
Netflix used to be the one subscription I kept while adding and dropping others based on content.

With the limited catalog, a general disinterest in all but a few of their originals, and the raising prices I'm thinking it's time to cancel and wait until something of interest lands on their platform again.
Introducing Svelte, and Comparing Svelte with React and Vue
If you open up a container going to a Walmart warehouse, it might be filled with massive blocks of bulky items of dubious fence value and can be difficult to dig to anything good. Even if you get something "good", having 30 pairs of Beats headphones isn't so personally useful or easy to unload for cash. And it's probably in a massive box that isn't easy to move and isn't easy to determine the contents of compared to others.

If you open up a container of UPS shipments, and you grab one random bag out of there-- there will be valuable consumer goods in it.
I defintely find "large" phones to be very uncomfortable and cramping to use for more than a few minutes. Thats why I haven't upgraded from my first gen iPhone SE. Thats even a little too big--the iPhone 4 and previous iPhones were the perfect size. I'm not a heavy smart phone user, but for the two weeks I had an XS, it was the most difficult phone I ever had. I couldn't hold onto it, and was dropping it constantly. So I gave it to my brother and bought another SE used (before the XS, I had an SE that got water damaged.)
You don't have to stay subscribed, think of Apple TV as $5 for a one-month rental and that's a pretty good deal. Schedule a reminder to unsubscribe if there's nothing else you want to see.
I'd suggest leaving and taking a break until your health issues are under control. Serious stress takes some time to work through the system. Be well!
Details please, which? Or is there a whole range of options?
Skio (YC S20) is hiring founding engineers in NYC
In my case more money is #1 reason for leaving. My job is just that - a job. I give my all while I’m working, and I expect to be compensated accordingly. I have a family already, I don’t look for another one at work. I keep it professional with a few jokes here and there. My comp affects my retirement, so I act accordingly.
Vaccine is no guarantee though, just look at Covid. DW was recently covering breakthrough cases that led to Long Covid. You're speculating now.
The problem is that people need houses to live in now. I can’t suddenly not need a house to live in simply because I feel very strongly that the trend of real estate appreciation won’t continue forever.
Or they could just want the money...

>Authorities said they seized more than 426 million rubles, $600,000, and €500,000 in cash, along with cryptocurrency wallets, computers, and 20 expensive cars.
What’s New in SQLite-Utils
I was playing hard mode accidentally. I didn't realize there was a more optimal way to play.