skysight-inc/HackerNews huggingface dataset:
A large part of this blog post's ridiculous assertion lies either on ignorance or on the false assumption that horizontal gene transfer [0] does not exist in Nature:

> It’s easy enough to change a single nucleotide (a single point mutation or SNP) or even insert or delete nucleotides (less common) but to insert 20 or 30 nucleotides with a code that works? Nope, that has to come from another virus or else it’s been done in a lab.

The original preprint which noted similarity of the HIV-1 sequences and those in the COVID spike protein, and on which this blog author's claims rest, was voluntarily withdrawn by its authors. [1]

Moreover, the assertions of uniqueness have been thoroughly addressed in the published article, "HIV-1 did not contribute to the 2019-nCoV genome" [2] :

> For any virus to obtain additional insert sequences from other organisms, it requires that it has direct interactions with other organisms, most likely through homologous or non-homologous recombination. [...] On the contrary, these motifs are widely present in various mammalian cells and so it will be more likely for bat CoV viruses to gain those motifs from the genomes of their infected cells if recombination indeed occurs.

That rebuttal article clearly suggests several feasible sources of the gene in Nature. That surely is more plausible than suggesting that Moderna or some other group nefariously created the COVID genome _in vitro_ before unleashing it upon humanity.

I deeply enjoy Hacker News for its ability to surface different ideas and sources of information that I would otherwise never find, but this article is simply ridiculous.

[0] https://en.wikipedia.org/wiki/Horizontal_gene_transfer

[1] https://www.biorxiv.org/content/10.1101/2020.01.30.927871v2

[2] https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7033698/
The mutation rate for proofreading ssRNA viruses is, affair, about 10^-7 per nt per replication. If we don’t see a particular variant nt it is (from the top of my head) because it didn’t “survive” the drift events or that there is strong positive selection on the sequence.

(Preemptive) Synonymous mutations are able to be selected, as they affect speed of translation and protein folding due to stalled ribosomes.
>2) Interest rates rising - he discusses this in the article. If interest rates go up from 5 to 10% then any notes I held on a 5% loan are worth less.

Maybe you meant this and just wrote it differently, but I'd argue it isn't that it is worth less so much as its liquidity has declined. You felt good enough about that 5% at the time you bought out the mortgage, but now it isn't as good a return as you would get if rates were at 10%, thus it may be difficult for you to sell that mortgage off to someone else given their opportunity cost.

On the other hand, rates (at least in the US) are unlikely to jump even a full 1%,let alone 5%, in such a timeline that you couldn't retrench if you believed you were better off to liquidate and move on to higher yielding assets.
> It hurts no one

Unless of course one of the boxes had something like epi-pens or insulin or some other medical supplies of course.
That question does not need to be asked. Nuclear power is dangerous and needs to be done with extreme care and extensive regulation. A worst case nuclear disaster can have local and not so local effects which are worse, sooner, and longer lasting than any global warming threat. If you are careful those things don’t happen.
That's how science has always been. People bet on hypothesis and try to prove the validity of the hypothesis. It's hilarious how much shit talking has gone on between scientists since the 1700s. Science "battles" aren't new
Does Not Translate
I do appreciate that Dolby digital 5.1 has become more common as a standard release and don't require a remux download.
The original claim you were attempting to rebut:

> If you are in your 20's, it is totally worth moving to the US where you can get paid 500K+ per year if you navigate your career efficiently.

I don't want to say that it's "easy" to hit numbers in this ballpark as a senior engineer in the US, but the way to do it is relatively straightforward and doesn't require any particularly unusual skills, connections, knowledge, etc.

1) There is a set of companies which pay that kind of money

2) Those companies employ a non-trivial percentage of the software engineers in the country

3) Those companies are _always hiring_ more software engineers at those levels

4) The interview processes for those companies are public and quite similar

Obviously nobody is guaranteed to get a job paying that well at one of those companies. Some people simply won't be able to clear the bar (either technically or socially). But the bar is not "one in a thousand". These companies already employ something like 8-10% of the software engineers in the country, so "one in ten" is a hard _upper bound" on how strict they are (and obviously, since their selection process isn't perfect and they don't in fact have every single 10%ile engineer or better locked up, the bar is lower, probably much lower).
It sounds like Oklo didn't bother to try to figure out what the regulators wanted, since they didn't bother to answer the questions of regulators.

I've done some first mover approval work in biology, and yes it's more work, but all first movement is more work in every way because you're pioneering something new. The FDA, at least, is not unreasonable and is usually very open about the bar they think they need to set. You just need to talk to them, request a meeting, and show up. And also realize that it's going to be an iterative process, as any new product design process is also iterative.
That code is older than C++11, let alone C++17. Also, your proposal isn't as efficient, since it calls strlen on construction of string_view (not that cost of parsing command line arguments is going to be measurable).
A co-worker gave me a PyQt application to hack on, and I just started searching things like "PyQt add keyboard shortcut".
I'm just a senior IC, and not at FAANG. But my employer does recruit from FAANG. 0%-20% sounds low for dev work, but the basic description looks somewhat familiar. We don't have project managers, and not all teams have product managers, so seniority can get you more of that work, and less dev work. I don't think ICs do managerial people management if you don't include mentoring. And I do know one or two directors who still code a lot. Maybe some FAANGS have senior positions with more IC dev work.
I also wish there was more about inflation risk.

After being debt-averse my whole life, I finally got a mortgage in 2020 when the prevailing interest rate dropped below the expected inflation rate. Because that meant real rates were negative, and sure, I'd love to get paid for taking out debt. At least so far, it's been a great trade, with me paying 2.75% on my mortgage and my home's value up about 35%.

Out of morbid curiosity, I'd like to know who I'm screwing over. Somebody out there is getting a 2.75% cash flow in a 7% inflation environment. Is it my mom's pension fund? The Saudi sovereign wealth fund? Wells Fargo? The Federal Reserve, and hence everybody who pays for goods with dollars?
I actually did quit caffeine, but I didn't entirely quit coffee. The alternative I drink (Rasa) has zero caffeine. So I do drink zero caffeine now, outside of a cup of decaf coffee maybe once or twice a week which is negligible. I also don't drink soda.
Oh how I agree about the uniform initialization! And to make matter worse, I now work on a code base where it is the mandated form in the coding standard. At least your initial example now gives me ammunition against it, but too late for this coding standard.

It makes code look silly, too, as now initialization looks different from assignment.

int i { a + 2 };
i = a + 4;

int j = a + 2;
j = a + 4; // ah! consistency!
> I'm almost like a customer successs engineer, product manager, scrum master, senior developer and tech lead all rolled into one.

This is also me. Except I really like it. But I'm not sure what to do about it, it can reflect super poorly on a resume for some reason.

"Oh, your applying to be a Senior Engineer? Look at all this product management and developer manager experience on your resume, you must not really be serious about coding, you aren't strong enough technically, the developers won't trust you"

"Oh, your applying to be a Product Manager / Product Director. Look at all this programming and tech experience on your resume, you are really just a developer, you should just be pulling tickets from JIRA/Asana/Linear, you probably wouldn't be able to speak in non-technical terms in front of customers/clients/etc"

(loop on repeat)

I've not heard of a job name/title/role that accurately represents this sort of work, even though companies generally seem to like it, if I can somehow get through their application process.
My approach is to employ folks with enthusiasm. If they're teachable, they'll figure out whatever pile of tools they get thrown into on the first task. Then they'll have some skills and the next task will seem less daunting.

Of course some mentoring is useful. But just the stuff that's pertinent to the task at hand; concrete help that gets them moving forward. Because, somebody is paying for results. And because producing results has a very positive effect on confidence.

I just offered work yesterday to a young person helping me at a big box store. I mentioned I was buying a device to test an Android build, and they got excited and started making cogent comments about the tool chain and devices available. I game them my card, and when they graduate in 3 months (from a local community college) I'll find them work on a client's contract.

The first project will cost me more than I earn from subcontracting them (because it takes me away from my high-rate work I would otherwise be billing). Maybe break even by the 2nd. But it's a sort of enlightenened-self-interest thing. If young people get into the field, everybody benefits.

And of course as an old guy with resources, I can afford to take some risks. Because it's everybody's job to look out for the other guy.
Option 1 is also attractive because it has a ready-made business model attached. Invent more doohickeys, buy and sell more doohickeys, install said doohickeys. If it actually works almost becomes a peripheral question.

Option 2 is long term, complicated, mostly requires buy in from several levels of underfunded state agencies. The private sector might pick up some crumbs.

Additionally, the people who make these decisions are probably pretty happy with the way that society is configured. Package theft is just a cost of doing business where the benefits are obviously enormous.
It's hardly easy with email. Keeping an up to date list of working addresses becomes a huge hassle once you get beyond a few people. I remember trying that in the days before Facebook and every time I sent a message it would bounce for some recipients.
It's a trade, the consumer exchanges certainty about costs for a higher fixed rate than they'd get otherwise.

If the consumer doesn't like that they can get a lower cost variable rate mortgage just as easily.
That's the opposite direction I'm trying to head. I'm at a huge company (relatively, I guess - 300+ ppl, got acquired by a several-thousand ppl company) and I'm eyeing a startup. I hate how corporate and over-policied everything has become.
If you want to test whether you already had EBV, then it would be a test for Immunoglobulin G (IgG) antibodies to the EBV viral capsid antigen (VCA). It shows whether the virus has established the latency in your body. Most laboratories would just label it as "EBV IgG", so just ask for that.

If you are in your 30 or older, then you most likely have had it already.
Wow, it's available for only $199 at https://mannkitchen.com/pages/pepper-cannon

"But, will there be too much pepper?"

"No. There will be the exact amount of pepper you want, ground more consistently, in a fraction of the time."
The code is ancient, and Google (like most) sees no value in modernizing old code, particularly for non-revenue-generating product. Furthermore, Google long ago locked themselves into an idiotically anti-RAII coding standard.

So, the example is of bad old code, at a place that enforces bad coding practice. The intent appears to be to suggest this is typical practice, which is not supported.
I'd encourage browsing their Trac for context.. the handful of regular contributors definitely don't need any extra bug reporters
Recall, if you will, that the rail lines are privately owned here. So you have privately owned trains, running on privately owned tracks that are on privately owned land ... it's not entirely clear what the legal framework for government police authority to take effect here is, at least not if you're concerned about the wierdness that would result from just saying "interstate commerce, put the FBI on it".
VMWare.

GNS3.

Docker.

Remember that large scale, complicated systems that work invariably start out as small simple systems that work, so build it virtually first, where you can break and re-build to your hearts content.
Weibo is a heavily censored and manipulated platform. The CCP uses it to track dissidents abroad.

Do not install or operate on any trusted device. Do not connect to your home network. Do not store personal details on your weibo device. Do not ever send sensitive information or talk to real contacts on Weibo.
> if the money in question actually were illicit, then by what fantasy argument would they be allowed to keep it themselves rather than having to hand it over to the goverment? The entire point is that the money is dirty and nobody may keep it.

I don't know what fantasy they operate under, but back in the 2010s I observed Google doing this numerous times with "seized" click fraud revenue -- one of my sites was a victim of a click fraud attack as an attempt to get my AdSense account banned, and my friend's site at the time was advertising on my domain via AdWords and he didn't see any kind of refund despite the $800 that was taken from me (which was the entirety of my revenue for that month). Google just keeps funds they seize I'm pretty sure, or at least they did back then.
> I’m trying to use as neutral language as possible

There's a framing problem here, on both sides. Notice how the EFF article starts off talking about how the recently enacted ordinance requires the police to get pre-approval permission to use facial recognition. But all that actually happened was the policed looked at live CCD footage from cameras not on the pre-approved list. The article is framing the debate by making the rules seem reasonable and the police seem sinister.

At the same time, presumably the reason you felt the need to qualify "disturbance" is because you recognize that on the other side of the debate are people who try to frame these protests in a negative light, with an insinuation (if not explicit assertion) that they inevitably descend into looting and violence.

Neither narrative is realistic, though in San Francisco the former group absolutely controls the narrative, and likes to play off the counter-framing about inevitable violence. In any event, there's no real debate here: just FUD on both sides.

When several weeks ago Mayor Breed said that the 2019 ordinance needed reforming, one of the drafters wrote an op-ed that said there's no need for it; that it doesn't restrict the police in any meaningfully way, and Breed's claim were groundless. That op-ed likewise tossed around the specter of facial recognition. But not once did they address the most obvious issue, which is that the police are severely limited in their ability to perform real-time surveillance of spontaneous and fluid situations, such as peaceful protests, riots, etc. The 2019 and earlier ordinances basically presume a context of continuous, 24 hour surveillance, access thereto, or after-the-fact evidence gathering. For example, requests to put up cameras on corners with high rates of crime or to deploy license plate scanners on patrol cars.

Activists on the left have lost all credibility, trailing right behind the right. Even the EFF has gone too far. The debate has become unhinged. It's become so adversarial that nobody even tries address the legitimate concerns of the other side, and facts simply take a back seat. There aren't any adults in the room. Perhaps that's because there isn't a room anymore--the entire conversation, even among the elected and professional classes (scholars, journalists, etc), has shifted over to social media, where success simply equates to spreading your memes (i.e. narratives, baseline assumptions, [poor] statistics, etc).
The majority of people who had prepared for the 2020 snap study elected to drop out after only a few weeks. Science, and humanity as a whole, are worse off as a result.
Like when Google’s smeared leap second leaked into the general NTP pool?
Seems like if the economy were a bridge then it would be held together with blue tack and bubblegum at this point.
Besides improving air quality you should use the vent hood anyway otherwise your kitchen will get a nice coating of grease on everything over the years. This applies to the oven too, not just the stovetop.

I wish residential vent hoods came with interconnects like commercial kitchens so they would come on automatically whenever cooking.
I ended up finding g that a regular old accountant that would help me run my own payroll for my one person llc was a drastically better deal then getting locked into some recurring revenue scheme.

obviously this could be different at different amounts of employees but it feels like the solve a problem and then extract every ounce of value you might have received so its not really clear what the benefit was after everything is accounted for
Wouldn't a person need to understand Chinese? or is wechat English?
Every single tor .onion URL in this article no longer works in Tor clients. Why? Because the tor project decided to throw away 15 years of communities and interlinking and search indices just to make sure people don't accidentally use tor v2 (which is still more secure than the clear web) and force them to use the far more secure tor v3 (an entirely new network). They did this in Oct/Nov 2021 after a couple years of warning of depreciation (not deletion).
People have always wanted to buy homes to live in. I'm talking about the large increase in prices in the last 2 years. [negative real] Interest rates are definitely a big reason for the asset appreciation.
In France too they had a troubled history.

https://en.m.wikipedia.org/wiki/Superphénix

https://en.m.wikipedia.org/wiki/Cadarache
Have they ever actually needed it? Did it work?
What percentage of your user base never activates tiling?

Are you sure you had to break things for them instead of only hijacking it when tiling is enabled?

And that still doesn't address hijacking the super key completely with cosmic.

Sorry but imo these things have been handled really poorly.
Mitochondrial Eve https://en.wikipedia.org/wiki/Mitochondrial_Eve and Y-chromosomal Adam https://en.wikipedia.org/wiki/Y-chromosomal_Adam

on edit: to clarify, these do not go far enough back to show the asked for source, so it seems unlikely that that would happen.
I wonder why fixed interest rates are so prevalent in some countries (like, apparently, the US) while in other countries the standard is to tie the interest rate to a reference rate (like EURIBOR in the Eurozone)?
You can run a water reactor with a much faster spectrum if you have more fuel and less water.

Shippingport was able to breed on the Thorium-U233 cycle.

Plutonium breeding could also be accomplished with a water reactor, possibly with two separate reactors in the fuel cycle to tune up the use of odd and even numbered isotopes. See

https://en.wikipedia.org/wiki/Supercritical_water_reactor

The trouble with it is that water has limited ability to remove heat so you are going to have a large amount of fuel tied up creating a critical mass producing relatively little water. That makes it hard to build up the fuel inventory for a fleet of breeders and economics are even worse than today's water reactors.
I get that there's a lot of fear around the idea that Covid-19 was engineered, and the potential fallout that could occur if it was proven to be fact. But I expect that almost all governments are now working under the assumption that it was, because they would be extremely foolish not to. So this is all a moot point -- at the top level, the working theory must be the lab-leak theory.

And so, fast vaccine production must be a priority. The development of drugs to treat viral infections and their manufacture must also be a priority. The ability to detect carriers and quickly shut down travel must also be a priority. And how do we enforce quarantine in populations that are resistant to it? All of these concerns are, I am certain, at the forefront in the mind of any Western government to be certain, but likely any government anywhere.

Because regardless of IF Covid-19 was created in a lab, it COULD HAVE BEEN created in a lab. And we all got caught with our pants down.
Think about having a robust network like being able to fly.

You don't develop the ability to fly by placing yourself in positions that require flying...

Most companies that have lots of attrition have bad processes in place and are suffering due to attrition, although I think there are some companies that are developed enough to benefit from attrition like you described.
Re: Eth tool, it compiles it down to bytecode?

Are block explorers prepared to show non-solidity code if the dev made the info available?
E'ybody wants to be a bodybuilder, but don't nobody want to lift no heavy-ass weights.

https://youtu.be/4UlgXIL0-3g?t=10
"Toxic culture is overstated" = "I've never sat down and had any serious work discussions with women in tech, but I think I know everything."

Toxic culture in engineering is terrible. I've been in many different engineering and IT work environments for decades, and have seen a ton of women get picked on and bullied, both overtly and just subtly. Yeah it's not all women--some evolve shields, some become passive and numb, some double down on skill to get 1x the credit for 2x the effort--but it's definitely very real.

I also think quitting has been driven by remote work. What happens if person A had remote work during the worst part of the pandemic, erratic petty tyrant boss A decides its time to "come back" or "go hybrid" even though it seems nonsensical to someone with broadband and a remotely accomodatable job--and then person B, who is spouse/friend/relative of person A, has a completely different situation where non-maladjusted boss B is like "yeah man, as long as you are getting your work done, I don't care where you do it."

There is a strong desire to dump "MadMen" type boss A with prejudice. Not always, some people love getting out of the house to work, but for people who enjoyed pandemic remote work, to have to give it up for arbitrary reasoning based on the armchair organizational psychology theories of some dumb manager--those people are going to skate, and they should.

It's like one the one side you have this vague meme of "in person team building" and on the other, real costs like: car wear and tear costs, gas costs, mass transit costs, parking costs, weather related time costs like scraping, increased accident risk from commute, lost work time during commute, different/specialized clothing needs and uncomfortable work clothing standards, prep/logistics time like packing/unpacking/undocking/docking, MBWA/wanderer interruptions and ad hoc "coworker therapist sessions" in the office, less comfortable and ergonomically genericized desks and peripherals, uncontrollable environmental noises and temperatures...all to do something that can be done over a wire.

I'd sooner set an office building on fire than work out of it. I'm a genXer and I guess I get why boomers are like this but if you're my age or younger and you force people into an office, shame on your pathetic fake nerd soul.