skysight-inc/HackerNews huggingface dataset:
Look to FFTF for a completely successful fast reactor run in the U.S. that was unfortunately shut down for political reasons that, retrospectively, look like a terrible mistake.

One of the most interesting features of the FFTF was a sodium-to-air heat exchanger which is a key to fast reactors having superior economics.

That is, no nuclear reactor which uses a steam turbine is going to be economically competitive with fossil fuel fired gas turbine generators. Between the absolutely huge and massive steam turbine and absolutely huge and massive heat exchangers (look at how big the steam generators are in the PWR or the huge tube-in-shell heat exchanger used at Dounreay)

A closed cycle gas turbine will fit in the employee break room of the turbine house of a conventional LWR. It requires some kind of reactor that runs at a higher temperature than the LWR. I like fast reactors and molten salts but have a hard time being enthusiastic about HTGR and friends.

So much of the literature still looks like a stopped clock. People still compare nuclear to coal although coal has been economic for a long time for the same reason as the LWR... The cost of that huge steam turbine.

Problems with fast reactors I worry about are the fear of proliferation (not proliferation) constricting what you can use for fuel and (more so) the plutonium nanoparticle problem w/ MOX fabrication. Of course you don't need to use MOX or you'd think in 2022 you could use 100% remote handling and not have the problems that Karen Silkwood was worried about at the place where she worked.
"The goal," says Sarandos, "is to become HBO faster than HBO can become us."

https://www.theverge.com/2013/1/29/3930560/netflix-wants-at-...

(Jan 29, 2013)

I'd say they probably did accomplish that, but now HBO is still HBO and HBO has become Netflix in addition to being HBO.
https://tulanehullabaloo.com/57213/intersections/opinion-lat...
There are foundations or specific non-profits for that sort of thing, that coordinate funds so they support the project but are not there to enrich or buy-out the contributors. I would give money to then. For example, off the top of my head, Numpy has a foundation you can donate to that already has some big sponsors

Edit:

NumPy is a Sponsored Project of NumFOCUS, a 501(c)(3) nonprofit charity in the United States. NumFOCUS provides NumPy with fiscal, legal, and administrative support to help ensure the health and sustainability of the project. Visit numfocus.org for more information.

https://numpy.org/about/
Interview with a farmer using John Deere's new autonomous tractor (3 min video)
Great that I can vote multiple times. I left jobs because of life balance and flexibility but I consider both subsets of company culture.
Sliwa is a throwback to the 80s, just like Trump.
Lead does slow down sufficiently fast neutrons, by inelastic nuclear scattering. But this has a threshold (0.57 MeV); below that energy it hardly affects neutron energy at all.
Four candidates: hygiene, better diagnostics, different exposures, longer safer lives.
I calculated it on my blog a few months ago: Every year, it causes the loss of 4.6 million disability-adjusted life years due to cancers alone, and another ~2 million to autoimmune diseases like multiple sclerosis.

https://denovo.substack.com/p/epstein-barr-virus-more-maladi...
I definitely agree with the notion that property/physical business owners would want good surveillance. I don't see any good coming from LEOs having unregulated access to a facial recognition network that is funded by taxpayers and run by a private nonprofit with special interests.

Maybe I'm tripping and quasi-government surveillance entities funded by crypto-millionaires is okay as long as we can stop the looting.
Are you suggesting "political correctness" is the only reason someone might be discouraged from installing a program named after toilet humor and juvenile references to specific parts of the anatomy? I've let my kids watch plenty of children's movies with fart jokes in them, but I still don't want to hear more of that when I'm trying to use a tool to access a banking service. It seems there's even still a banking module with a crude poop icon: https://woob.tech/applications/bank.html

Doesn't really inspire confidence in their professionalism or trustworthiness with handling financial transactions, if you ask me.
Thanks! And not all primitives right now -- everything is a polyline for simplicity, but multiple shape support is definitely on the to-do list
I came to the same conclusion as well. Moreover, I was somewhat successful in healing post-viral CFS/ME using the therapy targeted at mitochondria with large doses of B1 and B3 vitamins [1].

[1] https://news.ycombinator.com/item?id=29138006
DeepNull: Improving the discovery power of genetic association studies
Everyone always feels like the other person started it and did worse. That's a universal cognitive bias. Also, when people get moderated, they often instincitvely feel like the mods must be against them or their views. So I understand the temptation to react in these ways, but it doesn't help make the site better.

You (by which I mean not you personally, but everyone here) need to follow the rules regardless of what other people are doing. Taking the intended spirit of the site more to heart would be helpful: https://news.ycombinator.com/newsguidelines.html
> When people complain about Electron and similar cross-platform solutions, this is the alternative.

I'm pretty sure the alternative was nothing; their local download center doesn't need to exist, let alone be portable. Just have a web page with downloads.
Reading through the comments is interesting, I seem to be one of the few looking for a more intense job rather than less.

My current job, given who our customers are (the code does something a little more serious than advertising), should be a lot more intense than it is. At present we're just half-assing everything and cashing the checks. Sure it's easy, the pay is industry median, and the benefits are above average. That's not why I got an engineering degree though. What example does that set for my future kid? Bust your ass to get a STEM degree so you too can find a mediocre job with a sandbagged contract to comfortably mooch off of using a tiny fraction of your talent? I can't even really justify it from a "looking after my family" standpoint, because while the income comfortably pays the bills it certainly isn't going to pay my kids' future college tuition and buy us a good house. If I'm going to turn into a jaded clock puncher there are much more lucrative clocks I should be punching.

I'm not so naive as to expect zero bullshit and engineering purity, money is ultimately the game at any private corporation. But we could be making the same money and doing a lot more. Issue is there's no business incentive to do that, and no way for me to provide said incentive in the short or even medium term. Even if I went management there's no single position I could target that would make a difference below the Executive level, and the longer I work here the more I see how that's by design.

What with a kid on the way I'm staying put for the next 6 months at least. Don't want to be changing insurance during the wife's pregnancy and she'll obviously need some stability after the fact. But after that I'm looking for a job that's 50% bullshit instead of 90%. If I can say one thing for this job, it gives me a stable platform so I can be picky about my next position :)
PayPal and Ebay are like toxic waste. I've had both accounts frozen. Most recently my Ebay account for a reason they will not explain and will not allow me to appeal.
Yeah, but will the vaccines be effective? EBV is amazingly good at immune evasion. Prior antibodies don't protect against re-infection.
In my case I did not look for another job. I was scouted (ex boss recommendation) and took the offer. I bet there are many others like me - frequently getting offers.
I don't know enough about what a "balloon mortgage" is to comment on that, other than to say that the 2008 mortgage crisis was not as severe in Canada as it was in the United States.

So, to the extent that mortgage terms were a factor in the crisis, and I don't know whether it was, I wouldn't say that this kind of mortgage was disproportionately worse.
Goggle's and Facebook's CEOs Oversaw the Creation of Advertising Cartel
[this is not medical advice]
Some things that may modulate the immune system are: vitamin D3, intestinal worms, exercise, diet / fasting, and gradual stimulation of the immune response ("desensitisation").
That doesn't sound right. The rate is fixed till the renewable period, typically 5 or fewer years.
Utopia Shaped the World
> *As of writing this those links are still up which at 12 months is pretty good going for any article that dares challenge the drivel propagandised by our beloved “free press [sponsored by pharma]”.

Well this is a rough start. “This information is being suppressed, which you can tell by the fact that these linked articles are still available.” The utter lack of critical thinking doesn’t make me expect much from the rest of this.
The reason this is surprising is because THC is the psychoactive ingredient in weed.

CBD is mostly accepted as a milder agent, and has had medications containing it approved by the FDA, like EPIDIOLEX.
Another reason his probabilities are garbage:

Nature favors sequences that work. Try a billion variants, keep the one that actually helps. We don't see the 999,999,999 failures.
Don't give money to the developer, give money to the project. For example, create bounties for new features or issues fixed. Try to estimate the development time needed for a feature/bug fix and pay a good rate depending on that.
Here's a John McDougall talk, he had some close ties to Dr Swank, known for a lot of early MS research.

https://www.youtube.com/watch?v=fmZdI8jinIw

tldw:
When your stomach layer is compromised, unprocessed food gets into your body.
Food like animal protein, similar to our proteins, get attacked by the immune system, some of your cells are also mistakenly attacked.

Anyone with the compromised stomach is at greater risk for auto immune diseases.
For example look of rates of ms among celiac or crohn's sufferers.

Same goes for type 1 diabetics, also autoimmune. Research suggests casein from dairy gets in the body, your immune system accidentally attacks your pancreas insulin making cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518798/
It came out of research at Harvard (by the authors of Getting to Yes) and is related to game theory. So it's academic (and therefore jargony) but is probably also intended to be more precise than alternatives or options.

That said, for day to day use, understand your alternatives if the parties can't come to an agreement works perfectly well.
Same here, the progress bar animation seems to be a dummy. The actual search result is eventually returned over a `text/event-stream`... which seems to be struggling currently.
For the curious: in 2019 the average house in the US was 213 square meters: https://www.rocketmortgage.com/learn/average-square-footage-...
Honestly, putting aside the philosophical debate, I own something I have access to without limitation and without the ability of a third party to take it away from me. I own a book I can read whenever, wherever and however I want. I don't own a book I have to give back to the library. I own blu rays I ripped in a similar way.
If you have Java installed, just download the zip, extract, and run ./jailerGUI.sh.
Battery powered grinders being the hot new thing.
Some questions from a layperson:

1. Why do we care so much about a furin cleavage site? The author makes a big deal out of this and I'm not sure why. It seems like he specifically looked at the gene sequence at a furin cleavage site and then said: hey look, this occurs at a furin cleavage site! It must mean something! (Thanks to etaoins for finding at least some evidence that furin cleavage sites are not, in fact, unusual in Coronaviruses, although I have not read the paper: https://www.sciencedirect.com/science/article/pii/S187350612...)

2. What does HIV-1 have to do with anything? That is, if these sequences all matched virus XYZ instead, would that also be some sort of smoking gun? The top 3 sequences all seem to be very common among lots of viruses (rotavirus, measles, coronaviruses, and HIV all show up in the top 3 lists). So he seems to have found a single sequence that lots and lots of viruses have (at least variants of), and that one sequence is the first 3 rows of his table. Am I missing something?

3. If we ignore every result entered after Feb 2020, aren't we throwing out a lot of sequences that were entered specifically because people were suddenly all very interested in Coronaviruses? If he's making claims like "these don't appear in any other Coronavirus", the "except those we found after everyone started looking at Coronaviruses much more" somewhat detracts from that, doesn't it?

It feels a little bit like finding a passage "He froze, trembling with fear" and saying: the English language has 1 million words, so the probability of finding these 5 words in order is (1 million)^5. Therefore if we find it in two novels, one must have plagiarized the other. But not really though, because "he" and "with" are extremely common words, and "froze", "trembling", and "fear" are very highly correlated to each other. I think it's pretty clear his first 3 examples are all highly correlated.

His last example (and the title of this post) seem a little harder to explain to me as a layperson, but I'd note that for a 30-nucleotide sequence, there are 3^30 other sequences that are only a single mutation away. We again see Rotavirus on his list. How far away is that Rotavirus sequence, and do we think it prohibitively unlikely this sequence came from Rotavirus?
I'm single, in my late 20s, and live alone in a big city.

When $PREV_EMPLOYER closed the office in early 2020 and everyone shifted to remote work, I learned how much I depended on coworkers for daily social interaction. My friends live far away, so the last two years has been extremely isolating and lonely.

That lack of socialization meant work rapidly deteriorated into "just a paycheck" territory, and once that happens, there's no going back.
Some vaccines (like VZV vaccine) persist in the body.
From the articles I've seen, about a year, maybe two. Similar chemistry to olivine I think, but the idea is to use more concentrated CO2 from DAC or fossil exhaust, and pump to basalt formations deep underground. The olivine schemes I've seen use it as beach sand, absorbing CO2 from air in a weathering process.
The stakes remain unchanged, because the stakes are the packages.

Since there can't be that much profit in this activity, I think it's reasonable to assume that a lot of the people responsible are doing it just because it's easy.
Government technically isn't holding the mortgages - Fannie/Freddie/etc. buy the mortgage, repackage them into securities, and then sell the securities. The flow analogy in the article is really good - mortgages flow through a lot of intermediaries and get traded on markets. (The exception is the Fed's purchase of RMBS, which actually is a quasi-government agency holding mortgage assets. It's more like 25%, though; the Fed holds about $2.6T in RMBS, while the total RMBS market is about $10.3T.)

The socialization-of-losses aspect comes through interest rates. When wealth isn't held but is traded on markets, there's an incentive to hold interest rates artificially low, because that makes asset prices artificially high. High asset prices benefits all asset holders, so you can make people happier than they otherwise would be simply by keeping rates low.
You won't get everyone in your family to move from social media to a family mailing list.

But a third party app that forwarded fb updates to a mailing list ... That's something I'd pay for.
Retirement. I invest excess into sp500 and bonds and plan to retire early. Comp is a big factor here.
FFmpeg 5.0 Released for This Popular, Open-Source Multimedia Library
So you stated something that wasn't true (Jim conceding), I pointed out that that wasn't the case, and then you flagged my post. So intellectually honest! A true gentlemen!

In any case, let's argue in good faith about this one specific moment you pointed out. The question in hand is if Gradient Descent in ML should be considered a "Search" problem. Lex argues that it is a "Search" problem and Jim is arguing that "Search" has a specific meaning in CS, and ML Training is NOT that.

Jim's understanding of the word "Search" matches my own. Search is a process of looking for a particular data or __specific__ outcome. What happens in ML during training could be described as optimization, filtering, and, obviously, training, but in no way does it fit the definition of "search".

For reference, my definition of "Search" corresponds to the formal definition described hear: https://en.wikipedia.org/wiki/Search_problem, Lex's does NOT, and this is what Jim was pointing out. He eventually gave up when he figured out that Lex was using a colloquial definition of search, not the technical CS definition of the same word, and "conceded" by saying "sure, if that's what you mean by search" or something to that effect.

I would appreciate if you wouldn't flag this comment, but rather engaged with it, like an adult. Thank you.
A wooden house can be very affordable, but also tricky. The wood should be well dried. There was a wave of interest in wooden houses in 2015-6 AFAIK, which resulted in vendors shipping not-yet-very-dry wooden constructions to their customers.
These guys are planning to fly a prototype in 2023.
https://orbitalassembly.com/
I left my previous job of nearly eight years last month. Leadership decided to force vaccine mandates (the you-get-the-vaccine-or-we-terminate-you kind) in August with a deadline of mid-October. I was sort of on the fence about getting the jab but ultimately decided to leave because mandates cross a line. I ultimately got vaccinated, just long enough to keep that role until I found something new. My current employer has no plans to force people to engage in behaviors that should be a personal/medical decision.
Might be worth saying "it is not rational to leave a 15% pay increase on the table" than 20k. At 200k / year, I would absolutely ignore a 20k pay increase if company culture sucked.
My wife and I will have our first child this year and my employer offers 4 months of paid parental leave, so I guess that is sort of a golden handcuff at this point.
The network effect in 2005 was 5 people including a link on their site.
FWIW when renewing our home insurance they asked whether we had any EVs that charge or are parked in our garage. I’m not sure how it would have affected our premium as I don’t own an EV, but the fact that they’re even asking makes me think they must see it as an elevated risk.
> Why is it so hard for many HN readers to consider that cannabis might cause schizophrenia? There are tons of studies demonstrating a correlation, so it's not impossible that there is a causation too.

If you went to school in the United States in the 1980's or 90's, you were lectured consistently and repeatedly by teachers, parents, medical professionals and police offices about the horrendous dangers of marijuana. The basic storyline was something like: if you took a puff of marijuana you would quickly degenerate into a slobbering drug addict and end up fellating some crack dealer for a $5 rock, after which you'd contract AIDS and die an agonizing death. So over the years, the folks doing the anti-cannabis messaging lost a lot of credibility, which is why folks are rightly skeptical of new anti-cannabis claims.

Note: There's a little hyperbole in here, but only a little. U.S. drug education was pretty bonkers in the 80's and 90's.
Yes, I know BWT has nothing specific to do with bioinformatics, but BWT-based compressed indices for bioinformatics is its main practical application today (bzip2 isn't competitive any longer, no one is more sorry about that than me!)

But it's a good example of the thing I say: Even for pure math papers related to BWT, odds are good they use DNA as an example. I wouldn't be "thrown for a loop" at all from your clever bio-themed interview questions, and there are a lot of people like me. Maybe not who love BWT as much, but who in exchange have actually studied bioinformatics.

I'm not sure we're better candidates for it, so you're bringing in some questionable bias.
> I'm pretty much near the peak of my salary band in my region

I assume you're not interested in working remotely?
I really like it though.
What happens when you open in AI/Inkscape? Do they get mangled?
Wow, this is exactly the kind of tool I need. This has been in the back of my mind for years, happy to see someone already did the work to build it. Excited to try this out.
> All banks I've using have strong 3D secure.

I've yet to see any bank in the US implement such a thing.

Citi, Discover, American Express, Chase, and my local credit union all lack such a two-factor setup for charges.
My first thought was that I might swap in HBO for Netflix given this change, especially since the more expensive HBO plan is on sale for $11.99 right now.
> the spike protein from a new virus and splicing it to the backbone of a known one like SARS

The spike protein was already a defining feature of SARS-CoV when it emerged and became "known" [1]. That's why it was classified as a coronavirus! [2]

Edit: Appears I have misread, see reply

[1] https://www.science.org/doi/abs/10.1126/science.1086418

[2] https://en.wikipedia.org/wiki/Coronavirus#Structure
woob woob woob!
Battletech pulse lasers anyone?
New theory proposes ‘forgetting’ is a form of learning
> That doesn't sound right.

It is.

> The rate is fixed till the renewable period, typically 5 or fewer years.

Lenders and mortgage brokers will often heavily push loans like that, ARMs with a short initial fixed period, using the (usually slightly) lower initial rate and the prospect of refi before the float as a hook, but full-term fixed-rate mortgages are still more popular.
It’s no wonder the US health care system is twice (or more) the cost of every other county
Given the limited resource at the disposal of an open source project team, they need to pick their battles carefully to produce the most value with the least resources.

For a mature project such as FFmpeg, migrating to a new bug tracking system may produce some value to a small set of people who are reporting bugs, but for the vast majority of FFmpeg users, it produces no value.

So in this particular case it seems like they are willing to sacrifice the convenience of a small subset of users in the interest of the whole user community.

This applies to many mature and long running projects.
> We've gotten a lot better at recruiting CS students from underrepresented groups (women and BIPOC chiefly), but numbers drop off quickly

Are you really better at it if you can’t retain them in the long run?
The stats you shared are interesting, but to me it seems to highlight that students are getting “weeded out” at the beginning of the course. I would be curious to attempt a correlation with High school GPA and SAT scores. Because, if lower performing students leave, regardless of gender or race, that’s to be expected. But if overachieving students of color leave and their (white or asian) peers with lower grades don’t, now that’s an interesting issue.

> Students arrive in intro CS courses, are sat next to students who have been coding since they were 10, and are rightfully intimidated even though they could succeed in the course.

I would argue the solution here is to have different “levels” of intro courses. Because the converse is also true; students that are coming in with a decade of coding and who already had an introduction to programming might assume they will be able to “coast out” courses and then suddenly realize they are falling behind their peers. And then drop out.
Bintris – Golang Mobile Game