skysight-inc/HackerNews huggingface dataset:
Then why hasn't the same thing happened to ketamine for the treatment of depression?

Ketamine is widely available and cheap, but the FDA approved esketamine (the S enantiomer of ketamine) and gave the pharma companies a patent for the formulation so they would fund the clinical trials that are needed for it to be used as a treatment of depression.

Esketamine is much, much more expensive than ketamine, and essentially the same molecule, yet it hasn't been 'outcompeted' by ketamine (in the context of treating depression).

Because the new ivermectin (newermectin) would be specifically authorised and used to treat covid, it would have a niche advantage over ivermectin. Ivermectin would still dominate treating parasites, but there would still be good money in developing newermectin.
Incomes have been rising steadily since the Industrial Revolution started 250 years ago.

It's not easy to compare, but we're paid 30-50 times more now.
Coronavirus: Vaccine may affect menstrual cycle, study finds
I know where you're coming from. I've experienced the shock of switching from a nimble startup to a large tech co with teams for UX research, web, mobile, backend, platform, infrastructure, observability. Took a good while to get used to it. Each project has had it's prototype phase where core stuff gets figured out and a proof-of-concept validated. The productionization and stream of shipping PRs to deliver that over the next N months can be a lot. Then a new project starts and things are new and interesting in new/unknown ways. Pair programming helps, it's like watching a movie you like where you know what happens with someone who hasn't seen it before.

One thing that would help here is if new initiatives are new delivered artifacts rather than being tied to the CI/CD process of the established product. I haven't worked at a place that does this, but have worked at a place that didn't to its great detriment--instability of core product from changes made by new and slow new product development hindered by being in same monolith. Whenever I see a posting about a bank or other saying that we're big but have a small startup-mentality team, I don't buy it. Would love to find out I'm wrong on that.

I can't say for sure if any of those many startups where I did really cool stuff still runs those products. Possibly only in a sort of maintenance mode. What I'm working on now has more chance of being the foundation for something that lasts a lot longer, so taking a very long-term view makes it worthwhile.

I still do look fondly on the scrappy startup style of working in a small tight platform/API team where you can have a super technical discussion using so few words because you already know where the thoughts are headed.
I assume because they wanted to outsource it and relieve HR. I'm not entirely sure but I'm sure offloading any compliance with that data is a benefit too.
Bliss: The story of Windows XPS Famous Default Wallpaper
Thanks to the nature of S curves, it never was.
Rare to hear such a direct, strong argument for a union on HN.
> This is the reason behind the "keep your data confidential" idea.

It's also illegal under the NLRA of 1935. Employees talking about working conditions, like compensation, is a legally protected act whether it's on employer time or not.
I agree with everything you are saying. I'd like to share my perspective.

I quit my job for about 2 years, thinking I would never go back to full time. It was extremely liberating but also a somewhat scary experience. The reason for this is I think delusional thinking unfortunately plays a big part in what happens to people who stop working for long periods of time.

There are many, many people in my experience who stop working at some point, have nonwork become a big part of who they are, and never go back. They realize their current mode of work and life are making them miserable, so they throw out work complety instead of finding something more balanced.

I've met probably a dozen people like this and most if not all of them are in a deep state of laziness that is probably also a certain category of depressipn. Its quite sad when they realize they are 50, have no money, no way of making money, and no family because they couldn't afford one.

The author to me seems like a very delusional person. I hope I'm wrong but it just comes off as very naive. Is this magazine going to somehow change the world? How is he going to make money? How long has he not been working? How much savings has he lost in opportunity cost?

There is nothing more liberating than not working and convincing yourself that you don't need to work. For every 1000 people who think they are going to do this about 1 succeeds, and 100 manage to support themselves by living cheaply, contributing nothing to society, and mooching off of their relative, friends, and social safety nets.

I should also say I think taking time off, even long periods of time, is one of the best things that people who can afford to can do. It changed my life. I just wanted to point out there is a dark side to this, that a lot of people fall prey to. I could be reading too much into the article but I thought I'd give my perspective as I've thought a lot about this.
Hayden's Calculator Museum
I don't disagree with this. My experience though is that a more common reason it is a headache for some managers if their reports are sharing salary information is that they don't know how to have a conversation with someone about their performance. In particular their less than great performance.

So employee B comes in and says, "Hey employee A makes 15% more than I do and we have the same job! I even have more experience!" And the manager rates employee A's performance above employee B's so the salary is "appropriate" considering their relative productivity.

The problem comes in when the manager can't have an honest conversation with B to tell them this, and instead in their review gives them lots of happy talk and makes some sorry excuse for the small raise (or no raise!) saying something like "It has been a tough year and even I didn't get the raise I had hoped for! I really went to bat for you but nothing I could do could move them on available compensation." When, in fact, that is a lie and the employee is just being gaslighted because the employee would be mad and upset if they told them the "truth."

A good manager tells their reports what is expected of them and how it is measured so that when review time comes they are both on the same page when it comes to their pay. It also helps with making actionable plans to improve.

Sadly, there are a LOT of crappy managers out there.
So far the companies I've worked at don't have "vacation" or "sick" days, they have "paid time off" (which is really great if you're healthy and really shitty if you're not).
Many people have an ethical sense that if something is understood to not be done to them they will not do it to others.

It takes a while for people to learn that, with exceptions, companies have never heard of this rule. But it's understandable that people would still feel bad about doing stuff we've been taught all our lives isn't really a good way to be.

Sure, a company isn't your friend, but that doesn't make "betraying trust" in response a nice feeling.
Same here. Great. I wonder what other lies they believe about me.

On the one hand, I'm probably glad the data is shit? But on the other hand, folks consuming the data might not understand that.
There is no mainstream economic left.
The Lindy Effect is real.
Thanks for teaching me C and networking. You have a talent for teaching and I hope you're doing incredible things
Its certainly a reasonable comparison. But the important thing to remember is: There are plenty of highly marketable, valuable assets that have disproportionately little productive or utilitarian use-case. Fine metals, gems, art, high fashion, etc. People would certainly buy tulips as a fashion or aesthetic item; they have/had roughly as much utilitarian value as a diamond ring.

It was a mania in retrospect, because it blew out of proportion, but there's nothing intrinsic about the asset which would have made it deterministically, conclusively obvious to a knowledgeable investigator that a crash was in-bound (beside, maybe, its biological nature; biological investments are irregular). Rather, it was unsustainable because of the price; but what price is sustainable for tulips? What price is sustainable for bitcoin?

Markets are very, very weird; probably because human behavior is weird. An undeniable axiom: Markets can remain crazy longer than you can remain solvent. And at some point, a "crazy" market isn't crazy; its just the market. Many would say that a $10,000 engagement ring is a crazy asset to purchase; yet thousands upon thousands are sold & resold every year.
I like how they needed a dog to find the truffle. If that isn't the case with matsutake mushrooms, I'm going with the truffles.
More accurately where you were born and when your SSN was issued (my brothers who are four years older than me got their SSNs at the same time I did). Some of us older folks were born in an era in which you didn't automatically get an SSN along with the birth certificate. And then there are people who weren't born in the US so will have had their SSN not matching birth year.

I also think it's less than 5 of the 9 digits that are reflected in this manner. That would not leave room for a lot of distinction in SSNs.
Ask HN: What research questions do you want answered?
Feel free to be as impractical, inane, and/or idealistic as you wish. What have you been curious about and thought, "I wonder what would happen if you ran a study on this..."

Here's a couple examples:

- What numbers are people least/most likely to notice missing in an ordered list of numbers? E.g. If you ask people to quickly scan the list [60,61,62,63,64,65,66,67,68,69], which element when taken out would have the highest/lowest % of people who respond that there are no missing elements? Is it numbers that end in 7? Maybe people always notice when numbers with repeated digits are missed (66).

-
In 1983, on Apple ][+ machines, I can confirm that I definitely saw R-rated pictures of women on monochrome screens via unapproved software running on our computers at the high school I was attending.

But we were more likely to get kicked out of the computer lab for playing unauthorized computer games than for porn. We were a weird bunch of kids.
I’m not assuming that.

I’m just suggesting some companies may want SREs who understand fundamental computer science and are able to apply it to novel problems, perhaps as a proxy for finding candidates who could create their own terraform or quickly learn whatever tool may supplant terraform in the future.

As an analogy, it’s valuable to hire an electrician who knows the whole electric code really well, even though your project may seemingly only require a subset of that knowledge. For example it’s not obvious adding an outlet could require rewiring the whole circuit and upgrading the panel to meet code.

Symmetrically, as you point out, one may find value in hiring a less expensive handyman to do their basic wiring, if you’re confident you just need a dimmer switch installed.
I can't access my own data.

Someone already signed up using my SSN.
> Someone with the "wrong" degree but talent and relevant experience would easily beat someone with a fancy "Masters of Information Security" degree that then muddled around in less relevant areas.

Sure, totally agreed.

> Focusing on people's degrees is almost always the wrong measure in IT.

Maybe 20 years ago. (I was there.)

Today, asking for exceptional technical depth and a proven track-record of leadership is not a big ask.
I was surprised for about half a minute. Then I remembered, if it's not explicitly illegal and there's money to be made, of course they're doing it.
Slack is good too, generally chat rooms where devs hang out

The main two sided market problem is that most devs typically already have a project and are looking for help or users
It's not an absolute but it is a strong tendency which seems evident with omicron.

https://en.m.wikipedia.org/wiki/Muller's_ratchet

Noteworthy exception in virology is Marek's Disease:
https://en.m.wikipedia.org/wiki/Marek's_disease
But is your salary data on this equifax site?
I feel this is already what we get with IDE auto-completion and snippets.

Then some people push it further with personalized dictionaries and TextExpander like extensions at the OS level. I am not sure how much a dedicated hardware device would be an improvement, at least it wouldn't warrant the learning curve and portability issues to me personally.
And you'd need to know a past employer, right? I couldn't seem to find a way to get access to the info without inputting an employer first.
The top result is Wikipedia, "Web3, also known as Web 3.0,[1][2][3] is an idea for a new iteration of the World Wide Web that incorporates decentralization based on blockchains.[4]"

And even then, with federated services you still usually aren't hosting your content, that's really closer to what web 1.0 was, imo.

I guess the term is still nascent enough for it's meaning to be in flux. Hopefully good people are pushing it to align with the best tendencies
If climate change is really so bad, then people who use fossil fuel power having to subsidize people using solar power is a good thing.
There are drugs that are taken by millions with NNT in ~100s e.g., statin.
Is it not always like this?
Yes, most of Airbnb's backend is JVM:
https://medium.com/airbnb-engineering/building-services-at-a...
Anybody above 160 cm consumes too much energy so we only hire below that for a greener planet.
Is your info listed?
I'm not going to touch this website because I don't want to learn in 6 months that I was actually agreeing to sell off my soul and house but...

The previous addresses thing makes me feel like this will get taken down very soon. Everyone knows that abusers and stalkers can make very dangerous use out of addresses. It's only going to take one terrible incident before this gets investigated by the government.
Bath posse, represent.
Web2 was never about privacy, it was the opposite. It was about monetizing what data/content people would give up for free.

Decentralization has existed before web2 in BitTorrent but we don’t talk about that, do we?

Like communism, it’s adherents will say real decentralization has never been tried, but, just like communism it has, and when it’s ideals face reality you get something very different than imagined.
Android's Green Bubble Is Real
This has been posted numerous times over the last week
Why not just give them the next title up?

If you're looking to hire someone for an Engineer position, and they're demanding Senior Engineer pay, and their skills are worth the money, then why not just call them a Senior Engineer and be done with it?

And worst comes to worst, if they end up not actually being worth the money, you can always fire and replace them once you no longer have a project deadline breathing down your neck.
Mistakes are for learning. Admitting mistakes is the first step to solving. Your boss's style may be bad, but you can be sure that you cannot change his bad style.
Google asks for SSN for background checks and whatnot.
I don’t get the obsession with building an “empire”. Why is that even something people find noble or the actions of a “responsible elite”? Imperialism quite literally has destroyed the lives of millions of people in the service of a privileged few.

If you really wanted to be a responsible elite build public goods, not an empire.
I imagine that like everything in nature both extremes and everything in between existed in prehistoric human life. There were probably tribes that had so much bounty for generations life was easy, and others on the constant brink of starvation. Places that were peaceful, places with bloody conflicts..
Salary data should be public anyway. Let’s all share ours. I’m currently contracting for $95/hr. My most recent salary was $140k, my most recent contracts besides my current one were a flat rate $24k contract for up to 80 hours and a short term contract for $100/hr. (I obviously like my current contract quite a lot)
COVID vaccines may briefly change menstruation, but you should still get one
> there are legitimate reasons why this system exists.

Not really.

> If you're applying for a mortgage, how do you expect them to verify your salary? You can submit paystubs, but those can be faked. Same with bank statements.

Faking paystubs and bank statements is called "fraud" and most people are pretty reluctant to commit it.

> And if a bank calls your employer to verify your salary, and they have your DoB, SSN, and home address, it's pretty likely your employer is going to tell them anyways.

I find that hard to believe. The person who answers the phones for payroll would be worried about disclosing too much and getting fired, and legal constantly tells managers to keep their mouths shut to avoid saying something that could get them sued
Bitcoin is like the steam engine. It will go away for things which are more efficient.
That doesn't answer my question at all - the statement was that it's "easier", not "cheaper" to go to that city at later time. Price is just one single factor that may influence how easy it will be later compared to now.

Maybe a significant chunk of your motivation to visit city A was to see it covered in snow and do some winter sports, so if you cancel it now you'll likely have to wait a whole year to do it again?

Or maybe you booked these trips to see some bands playing life? What if the band playing in the cheaper city is less likely to play again within your reachable area in foreseeable future?

There's a huge amount of reasons why canceling the cheaper trip may not be the best option, and I believe noticing that is what the article was actually talking about.
> How should I proceed?

My suggestion is that you didn't know what you didn't know. Your Boss's boss should not have ambushed you like that either. Consider talking with your boss to have them expressly describe what their expectations are and how they are measuring them. Then, using the same way they are measuring, measure yourself and check with your boss to see if it matches up. It will help you understand what is expected and it will help them see how you hear what they are asking.

Also, have your boss put their expectations and their measurement criteria in an email to you, also email them with what you think the measurement should be and get them to confirm, in email that you are correct. With that information in hand, you cannot be ambushed like you were because you have "the receipts" as they say. What's more, if they fire your boss, and the next boss doesn't know what to put in your review, go over your email with them and that will set them straight.
That is not even true, they are affiliated with NGI, the jokers that funds stuff like this:

TENACIOUS: Trustworthy sEmaNtic Aware marketplaCe for Interoperable clOUd Services

https://ontochain.ngi.eu/content/tenacious
Is this just for United States?
Nope. Didn't in my case.
It’s doubtful it comes from your employer, it more likely comes from credit applications.
This can derail the convo a bit, but one of the major criticism of React as a view layer library is that it shepherds you into doing a whole lot, much like a framework.
For employers it offloads employment and salary verification. Instead of having to pay someone to answer verification calls all day they just upload the data to The Work Number and let them handle it.
We call it "lobbying" here and it's only available to people far richer than most of us.
Yes you do it's called taxes and you spend it on something I already have
I guess. I always thought b/g checks are done via third party but I don't recall being asked for SSN during that step. It's been a while so I guess I am not remembering right. Thanks.
How did you request the report?
top 5 facts for successful life
I use github for 0$ a month
The new hotness seems to be html over web sockets, which Rails does.
If you have nothing to offer, you build and empire to create importance for yourself. At least the illusion of it. The most wretched shit people I’ve ever worked with are empire builders.
Better a freedom to consume things than a freedom to buy and sell things.
Check if an ad blocker might be interfering? I finished my CCPA request in ~2 minutes and it only required that I do SMS verification. Presumably because the name, phone, address, and email all matched records they had on file for me...
It is very strange that chatbots cannot improve in understanding. but I guess they need more than data to do that.
That's just not how business works - if you're in any kind of b2b business and the CEO of a $3Tn company calls you, you take the call and you bend over backwards to win the business if you can. If Tim Cook called Intel and said Apple was thinking about going back to Intel, Intel would surge like crazy to make it happen. The same exact thing would be the case for AMD or anyone else for that matter.
Green Bubbles: How Apple Quietly Gets iPhone Users to Hate Android Users
Actually for me Google and Facebook is there, but Amazon is not.
And the linked article and the common references to it highlight almost exclusively "wrong degree/education" instead of "no relevant experience/track-record" (if that's the case, no clue what her experience looked like on paper. but the article also brushes it away with a sentence just to focus back on education). That's my problem with it.
Exactly - the overwhelming nature of these signals (e.g. the searing brightness of eye contact) pushes people away from them. This then produces difficulties as a result of not seeing these signals (and not learning about them). The result is a lack of Cognitive Empathy - inability to read signals - which is often confused with a lack of Affective Empathy as seen in sociopaths.
Allowing me to bikeshed for a second, was the progress bar a stylistic choice on this blog or part of some default styling? I keep seeing it pop up on random sites and I can't help but think people are developing on browsers that elide the scrollbar. Adding it back in seems like a signal that it was actually useful information for the user. I know safari removes it, not sure about chrome. Firefox does not remove it on desktop but does on mobile.
I was a little mystified when I read the following sentence, since the start menu (and taskbar) has in my experience always been part of explorer.exe, and not a separate process (unless he was referring to explorer.exe itself, which I've killed and restarted a few times without issue, so that couldn't be it either):

And one of the programs that this utility decide was not worthy of keeping around was the Start menu, so it terminated it when your game started. And then when the game was over, it relaunched it.

...and then all became clear shortly after:

But the Start menu is a UWP program, so it is supposed to be launched a special way, with specific command line arguments, and it is supposed to be run in a low integrity app container.

Raymond is obviously going to be pro-MS, but I can't decide whether the ultimate blame here is the third-party utility, or MS for the design decision that somehow the start menu needs to be its own process, require commandline arguments and whatever starts it to do something special (unlike explorer.exe, which establishes its own environment appropriately) or indeed the whole shitshow that is UWP.

Related: https://news.ycombinator.com/item?id=28449607

It seems people have tried replacing the shell with one from an older version of Windows, but it's not a direct drop-in (e.g. https://www.youtube.com/watch?v=RUsbU73Idx4 , warning: audio is useless); with some additional work, I suppose it might be possible.
Toshiba T1100 – the laptop that was named a milestone of electronic engineering
Good catch, I'll add that.