skysight-inc/HackerNews huggingface dataset:
Ask HN: Founders of medical device startups, how do you stay informed?
I wanted to include "successful" in the title, but alas, that was too long! I'm the technical cofounder of a medical device startup that's about to enter our first-in-man trials in the USA (Class II de-novo). Learning about regulated industries is difficult for startups, and while I think our team has done a fantastic job of learning the basics (including successfully submitting our Investigation Device Exemption), it has been an incredibly long slog of YouTube lectures, random blog posts, and occasional conferences to build the necessary knowledge to bring this product to market.

What groups are you part of, blogs do you read, books can you recommend etc etc that have proven helpful in your journeys?

Also feel free to plug what you're doing, always interested to hear what projects other people in this space are up to!
Here's HN's RSS:

https://news.ycombinator.com/rss

Let's hope it will not go defunct anytime soon.
Completely agree. ICUs in my city are at 98% capacity, creating life-threatening situations for both patients and providers.

IMO, the author makes a compelling case for why vaccines should be mandatory: people significantly underweight the negative societal externalities of not getting vaccinated.
AI’s 6 Worst-Case Scenarios
This happens at my work but if you click on a link you need to do a phishing awareness training module. I think this is an effective approach because it doesn't seek to punish anyone but instead train them to be more aware.
Linux supports this, but applications on Linux may not (or not gracefully). I've found Chrome on Ubuntu (GNOME with Wayland) just doesn't adjust its scale when being dragged across displays with differing UI scaling settings. I don't have this problem on Windows or Mac OS.
Thanks for sharing. Took me around 4 minutes and docked successfully on my first try. What a great interface too. Without training and without even looking at the instructions, I managed to dock it.

This may be a dumb question but I noticed something a bit odd. I had no trouble getting the orientation right and stabilizing those numbers. They didn't drift after getting to zero. But there was always a little drift on Y and a bit more on Z. A very small drift, but I was thinking I should have been able to completely stabilize it. That a single click right thrust would cancel out the previous single click of the left thrust.

But that wasn't the case. Is that a fault of the simulator? Or how a spaceship would handle in reality? That the translation movements can never be completely canceled out and have to be monitored?
I'm Hooked. Tell me more.
Whilst rarely a turn-key experience, there are plenty of games that run on release date on Linux.
Hopefully they'll let the farmers repair them when they inevitably stop working at some point.
You're missing the forest for the trees. This is what Capitalism has always been and always will be due to its incentive structure. If you accept wealth and thus power concentration, you accept market manipulation. The corps won't skip this due to some overarching ideological free-market reason. That's just naive.

I mean, just look at the jungle of regulations and the vast inefficient bureaucracy of the US healthcare system. Those 15k layers of shite can only happen with just as many corps doing everything to either save their profits or trying to get as large a piece of the cake as possible. Public good be damned.

Say if the US gov planned to add $100 per patient in some grant for whatever reason. How much do you think would actually trickle down to the patient? I'd be like nervously donating $100 to a dodgy charity in a corrupt developing nation in the 1960s.
I feel bad for Karen.
There's lots of stories of competitive rivalries within bands, and between bands (especially between rap artists in modern age), and between composers/artists. I think there may be something to this desire to one up someone in a creative field when you consider yourselves better than them producing great works.
It's worse than that. FB maintains "phantom accounts" for everybody whether you have a FB account or not.

I've never had a FB account, but some years ago I got an email from FB listing a number of my friends and family and saying, "All these people have FB accounts. Wouldn't you like to join FB?"

The email included a reply option labeled "don't contact me again," which I chose and then replied. But a few months later I got the same invitation.

Needless to say, I found that to be deeply disturbing, and it confirmed my determination to never subscribe to FB. Later I learned about the phantom accounts. I'm sure FB maintains a dossier on me to this day.
Yes, but this is snapshot at this current time, in a changing situation. The hospitalization rate for the vaccinated has gone up by a lot in the last month.
Long term we don't really know how things will go, and if there will be more vaccinated people in hospital in ICU than unvaccinated.

One plausible explanation I heard is that the immune system does not recognize the virus, but rather the cells infected by the virus. The immune system uses T-cells to destroy those infected cells. The drop in effectiveness of each successive vaccine, suggests a diminishing ability for the immune system to recognize the infected cells. And its not really clear if repeated boosting will solve this problem. I think of it as a ai that's been over optimized to recognize only the training data.

Don't really have a background to evaluate if this is a valid explanation of why we are seeing this inversion.
Final, final realization/thoughts. It's pretty obvious I let the curation of my Feedly go stale and that I should clean out the old cruft, and give it a try again. I forgot about the nice keyboard short-cuts for navigating article titles. And it's also nice way to view heavy news sources, like The Verge.

However, as a user I'd need to decide: do I want to open the funnel of content like this where I feel obligated to read all the stuff in my feed? I kind of feel like I don't need to be so diligent with these things. And if that's the case, my use case looks more and more like only using RSS for super specific, niche websites that I don't want to remember to visit on a regular basis. Which could be OK, but then I have to remember to visit my RSS reader.
> the city pays them for lost revenue every time they shut a street down for repairs.

Right. And that money comes from taxes, right? It’s plausible under the scenario you’re describing that fake QR codes could end up costing the city as well; contractor may argue the city is responsible for enforcing & cleaning QR graffiti. (I have no idea whether that’s the case in reality, just imagining ways it’s possible that you are paying for scammers even though you don’t think so.)

The regulatory capture sucks, especially if a meter contractor is preventing bikes lanes. The city needs to resist such stipulations, but I realize this kind of shit happens all the time. I wonder why the contractor would have such leverage; I would think the city’s in the stronger position. I agree with you, I wish the money were going directly to the city rather than for-profit businesses, especially when those businesses are draining city revenue on a larger scale than some QR hackers.
I'm trying to build GitHub for flashcards: https://github.com/dharmaturtle/cardoverflow

Emailing you!
Do We Prefer Praise from Acquaintances or Strangers? [pdf]
You would be surprised but that is exactly what you do when you access VMs on clouds.

To be short: if you can make your app less greedy - do it.

In some cultures we have a concept of "engineering conscience" (ru: "инженерная совесть"). Are we loosing all that?
Plots is still a problem for me. Rust and Julia have a lot in common in this respect, but I will gladly take the advantages of their package management systems if it means a longer compilation time.
> Advanced protocols may be able to use SRV records to distribute further traffic, but web browsers can't

Not for lack of trying from the DNS community, more like web browsers won't. However if you haven't already you should take note of the HTTPS and SVCB DNS record types: https://datatracker.ietf.org/doc/draft-ietf-dnsop-svcb-https...
The bulk of the traffic is serving static files. We figured out how to do this with "old and weak" hardware in the 90s.

Here is a 3.3 GHz Xeon, 24 GB of RAM, with the required disk and bandwidth for $33: https://oneprovider.com/order/item/dediconf/59
Draw something to a friend and leave it on the garden
[name redacted]'s [1]twitter feed is quite interesting when it comes to [name redacted]

[1]: [link redacted]
Someone needs to explain it to me because I'm still lost...
Oh, and LOGPIXELSX/Y showed up much earlier than Win2K. If you're getting that from MSDN, keep in mind that 2K is basically as early as the docs go, even if the actual API is much older. For example, it says the same for CreateWindow, even though that one goes all the way back to Windows 1.0.
Call it a feng shui thing.
I'm always torn between the Kerry and the Uni Kurutoga. I have both, and they are both a pleasure to use.
Yup that should do it
>I see a lot of these comments have taken to a kind of Amazon-bashing and venting their own experiences, where the author actually... didn't?

Nobody is dumb enough to write a blog post trashing Amazon under their own name. He wants to be able to get another job.
I feel the same way. One of the limiting factors in the growth of these programs is not just the funding for hardware and software, it's the lack of qualified teachers that can effectively develop and run the programs.

Fortunately, there are some State of Florida programs that will help fund teacher training for STEM subjects, especially computer science. (https://www.fldoe.org/academics/standards/subject-areas/comp...)

Finally, one of the reasons we started the podcast (and our school has been VERY supportive) is to share as much as we can about our experiences to help support and inspire other teachers. We're lucky that we could learn and work together. Many computer science teachers don't have any peers in their subject area. We wanted to make a podcast that allowed them to be the third person in the room as we talked through the challenges, successes, and lessons learned from our teaching experience.

It's been an extremely rewarding journey so far.
Plenty of good movies get made. It’s the compromises they need to make when aiming for blockbuster billion dollar revenue movies appealing to everyone globally which results in movies that suck.

A little pandering to the Chinese censors and nothing really offensive to anyone else etc.
I think at this point the metaphor of "function coloring" has been overused, and we should use the real name: monadic async. The problem is obvious when you look at what a monad is: you have lots of ways in, but no way out. So every monad has to offer their specific way out, if they can. With a Option<T>, you can extract the value inside your function with unwrap. Your function will still be a regular function. With async, you can do the same with await. However, await can only be used inside async functions. That's the trap right there. The way to get out of the async monad is only usable inside the async monad.
From looking at job postings, there's no shortage of jobs for people already in the industry, and a proportionally much lower number of positions for entry-level. Every company has open positions for seniors, but no one wants to train them up.
Why wouldn't PCR test and isolation be enough? Besides with Omicron spread risk is not really reduced. Seems irrational decisionmaking to me and more of a power move.
It's the right choice! When an open version comes, it will most likely be a community effort. I would do the same thing in your shoes.
"Does not meet expectations" is always a cop out, but a great catch-all if aren't an 80%er.
Ironically, it's struggling to load the images for me.
aaron was trying to warn us about something more sinister lurking beneath the surface
> remove basically all names from your own generation because they remind you of people you went to school with, remove the names of your parents' generation because they remind you of... well, parents

I wonder if this is what happened to "Karen" since it had such a sharp drop-off decades before it became a slur. I can't think of a more "baby-boomer white woman" name, so it's a neat way for people to wrap their sexism, racism, and ageism up into a single easily-deniable word: https://www.behindthename.com/name/karen/top/united-states
Not when one of the assumptions is that the shell will be seriously compromised at some point. Stainless steel is just another durability vs cost tradeoff, but it could be what makes the difference between repair vs rebuilding and it’s not that expensive.

Wood for example could hypothetically last that long, but both fire and leaks are a real concern.
I love the Pilot vanishing point fountain pen that has been my daily driver for the last three years. It writes beautifully and is 'clickable' like most ball point pens. I don't have to worry about buying refills and seems like the ink pot will last me a decade.

https://www.jetpens.com/Pilot-Vanishing-Point-Fountain-Pens/...
If you’re grabbing the wheels, you’re doing it wrong. Also, if you get urine on the zipper, you’re doing it wrong.
I don't think they're a store, everything is free and Patreon supporters get early access. I do occasional 3D rendering and the HDRIs are great. The downloads are fast enough to make you ask "whoa, how is this free".
They seem to really like the Uni-Ball pens, which I've used a lot and are OK, but I've switched very happily to the Inc R2 Rollerball [1]. Really dark and even line, very light pressure, and low friction. Just a very comfortable pen, cheap enough to have around the house by the dozen but feels like a high-quality pen.

[1] https://www.amazon.com/ROLLERBALL-Comfort-Flowing-Writing-Pr...
Lobby politicians to foster competition. The customer service is only allowed to get super shitty if there is not enough competition.

One large supermarket, that is part of a chain, for a town might be more efficient, but I bet two smaller, independent, supermarket would lead to a nicer experience.

Hell even just cracking down on vertical integration and having the one, independent, store would be much better.

These problems usually boil down to the idea that corporate power is some how right and proper, but government should be avoided at all costs.

Governments are how the little people tell the faceless corporate bureaucracies that they are doing a shitty job.
See also the PICO-8[1] or TIC-80[2] fantasy consoles: fake virtual consoles with built in editors and limited on purpose to add more fun and cleverness to development.

[1]https://www.lexaloffle.com/pico-8.php

[2]https://tic80.com/

Games are distributed using custom small PNG files.
It all sounded nice and good until I read the part about the microlab using spare bicycle tubing, and wanting drug dealers to cut heroin with PrEP meds...what can possibly go wrong with cutting everh dose of heroin with an HIV drug made through bicycle plastic tubing?
While I agree that patents are net harmful, especially in software, if you cut their term by a factor of 4 to 5 years, many of them would expire before being granted, which would be a hard policy to defend.
The topic here is COVID-19. Juxtaposing healthy eating with a vaccine is downright evil considering how many people such a suggestion has killed.
I agree, although the change was prior to 4-byte utf (2002 vs 2003) the same issue would have manifested with 6 byte sequences. Very curious.

It would be really interesting to see a postmortem by mysql if ever possible, because the more I think about, 3 is such an odd choice (pun), and people usually do most things for a reason haha, its either lost to time, or a brainfart off-by-one.
Ironically, I think the blog post would have been improved with some explicit self-promotion.
Exactly how does one get into a situation where your sound card isn't supported on macOS, other than by putting together a Hackintosh? :) You're going to have to look for some pretty edgy edge cases where you will be left rending your shirt and wailing "if only I could compile an open source driver for [insert thing] but the cursed closed nature of Apple products prevents me from doing so!" (I mean, I'm pretty sure people can write open source drivers on Macs if they want.)

Granted, as someone who's been using Linux sporadically in various ways for the same two decades I've been a Mac-on-the-desktop user, I can't remember the last time I was left rending my shirt and wailing "if only I didn't have to compile an open source driver for [insert thing] to get basic functionality working." (Although I can remember more than one time I ran desktop Linux in a VM on a Mac, and spent several hours doing web searches for how to get [insert thing] working to find little more than other posts saying "I'm running desktop linux on a VM on a Mac and I can't get [thing] working".)
I think this is the sort of thing you want to ask their sales team.

I thought about doing this a while ago, after I left my job with an ISP. I would just have bought transit from them (and maybe made them regret their 10Gbps for $1000/month plan ;)
Counterpoint, I didn't think there were too many options. It took me <1m to scroll through the whole list and select what I wanted, ignoring the ones I wasn't interested in. I thought it was perfect. If it was 5m, on the other hand, or had page after page of options with no end in sight, that would become tedious I think. But this was very brief and straightforward.
My go-to has been the Pilot Precise for many years.

Something about the stick rollerball means that whatever weird angle I attack the page, it writes. Ink dries instantly as well, difficult to smear it even on the cheapest paper.
Did you forget to read the last part, describing the major things that need to change?
option + command +f

Pop-up box comes up, here you can have as many credentials as you need, it saves them, just double click one and it will enter it in your terminal window. This an absolute life changing feature for me. I manage a ton of servers, and yeah we use SSO to ssh into them, but that is just ssh access. Once you are on a server they maybe several passwords and or accounts you need to login to or accesses (like postgres, mongodb, redis, etc.). Of course we have seperate passwords for each environment, so having this feature is pretty much a must for me now. Any terminal software that doesn't have a feature like this is a no-go for me (and so far iTerm2 is the only one I have found that has this feature, I have looked high and low for something similar native in Linux but have only come up with bupkis).

The other features I like about iTerm2 are pretty standard in at least a dozen or so other terminal emulators (tabs, split windows, etc.). Password management is THE feature that is painfully missing from Terminator, Tilix, etc.
What's your angle? How many social media followers do you have? I don't mean to sound rude, but this reads like you're falling for the same grift as everyone else.

There's a reason there's a whole lot of money sloshing around in the space. It's because regular people keep thinking they can get in on the action.
D has a BetterC mode without garbage collection

https://dlang.org/spec/betterc.html
Start a physical gathering.

There are lots of us that want to meet and aren't obsessed with corona. I hold regular weekly meetups and have done so throughout the last few years, it has been a welcome respite and I have formed some long standing and close relationships.

I have found the people I've met to be more community minded and more prone to take the initiative and branch out to new people.
I'm not that interested in using lower common denominator software on any platform - for my purposes I am only interested (and willing to pay for) software written to integrate with macOS in a first party manner. That means I want all of the accessibility controls to work, all of the system integration to work and so forth. I'd expect anyone serious about software to want the same on whatever platform they use. Lowest common denominator crap is the thing that needs to die.
Great idea. I was honestly pretty disappointed by how hard it was to put a blog post I wrote in Pluto onto my static website. I still really think Pluto needs a way to generate static markdown similar to jupyter and maybe create a button to "edit or run this notebook" as an image with a link to some javascript magic with the actual notebook embedded. I ended up having to use iframes which felt far from ideal[1] since the html output is a jumbled mess[2].

[1] https://projects.ansonbiggs.com/posts/2021-08-24-julia-for-m...
[2] https://gitlab.com/MisterBiggs/julia-for-matlabbers/-/blob/m...
> If you want to run apps like Microsoft Office, Wine is probably a far better bet. I'd be surprised if Darling runs complex Cocoa apps anytime soon.

The advantage of Wine is that it's more mature. The disadvantage is that Windows is possibly the least Unix-like operating system in popular use and the number of ugly hacks they have to use to make Linux do what Windows does will never cease to be a source of friction and heisenbugs.

Whereas macOS is a Unix, so Darling doesn't have to imitate all the eccentric behavior of the Windows kernel, it can just implement the API.
Surprising to see that this article has snubbed Chinese FP manufacturers. I own over 20 FPs and some of my favorites are ones made by Jinhao and WingSung. One might even say that the WingSung 300x [1] is better made than the pens that it is a copy of, i.e., TWSBI's Eco and Diamond. The Eco's body is made out of cheap plastic that decomposes when it comes to contact with many household chemicals (e.g., isopropyl alcohol). The Diamond's body is ostensibly better made, but IMHO it's still not worth the price. In comparison, I've used a <$5 WingSung 300x for over 3 years now and it's one of the best pens I've used hands down.

[1]: https://www.ebay.com/sch/i.html?_nkw=wingsung+piston
What @mellow said plus you (a) may need a bit of practice and (b) get a pen with a better grip.

I usually write 2-3 A5 pages a day, so writing 5+ would make my hand a bit stiff. If you write less than a page a day, you may want to take it easy at the beginning. For example, try a 5 minute journaling practice.

Grip is very important (saying as a leftie who uses fountain pens). You may want to look at a pen like Lamy Safari that has a grip that forces you to hold the pen correctly. Don’t use thin pens like Parker Jotter unless you have really petite hands.

As @mellow suggested, using a pen that flows well is necessary but not sufficient to ease the pressure on the page. If you are a heavy writer, it will take some effort to break the habit.
The map shows heavy concentration of ethnic Russians in the north of the country. Russian ethnonationalists often refer to north Kazakhstan as "South Siberia" for this reason, and there's a long-standing desire in those circles to annex it to Russia.

This is quite similar to Ukraine, where Crimea is overwhelmingly ethnically Russian.
JetPens have a number of sampler packs: https://www.jetpens.com/search?q=sample&v=2
I would take password-protected keyfiles - I would love it in fact. But AFAIK there's no way for the server to know if the keyfile was password protected or not. Is there? It seems like it wouldn't be reliable - you kinda have to trust the client to tell you the truth about whether or not it decrypted the keyfile before using it.