skysight-inc/HackerNews huggingface dataset:
It is routine for basically all papers in medicine research to be hosted on PMC. Often they host the entire article, not just the index and abstract. The reasons for this open access are complicated but boil down to certain rules from funding bodies.

I have no idea if the particular Elsevier journal (in the banner at top of the page) is reputable, but the science here seems at least robust.

If I wanted to discredit this paper, I would point out the authors developed an analysis technique they want to apply to other diseases/models. COVID is a nail and they have a specific hammer, no matter if it’s the right kind of hammer.
Not from the US and the idea of the US getting into a civil war seems a bit out of place to be honest.
>> That implies that folks who don't qualify don't get to go
> Well, yes, of course? Why wouldn't both the uni and students want a threshold to ensure that no one's time is being wasted?

Like I said, the US doesn't tell people they can't go. Your country does.

We also don't tell them what they can study.

> Since I'm not from the US I had to google the distinction and from what I can tell a community college main PR is that one may be "transferred" to more prestigious institutions.

Not at all.

Moreover, there are less-expensive "big-time" colleges. You only hear the stories wrt certain types of schools. (In most cases, they're the kinds of schools that are extremely rare outside the US. Even the second-tier schools in the US are very good. For example, Apple employs more graduates of a school that few people outside of CA have even heard of than it does graduates of Berkeley even though Berkeley is significantly larger than said unknown school.)

So, should we tell them "no" up front?

> > I've nothing against non-STEM education, but I do object to paying a lot for it.

> Luckily any decent society consists of more than smug tech folks like this place.

You already said that you/your country won't pay much, so why is it wrong for me to express the same sentiment?
> there are many other companies that can build the same.

if facebook/meta grabs mindshare early, and fast enough, the network effect would mean that another startup cannot compete (without an extraordinary amount of luck or innovation i suppose)
Check out “rewrites”: https://nextjs.org/docs/api-reference/next.config.js/rewrite...
> The version of the updated scan engine starts with 2112330001; is this right? Should we be concerned that it seems to reference a date that does not exist?

> The newly updated scanning engine is fully supported by Microsoft. While we need to work on this sequence longer term, the scanning engine version was not rolled back, rather it was rolled forward into this new sequence. The scanning engine will continue to receive updates in this new sequence.[0]

[0] https://techcommunity.microsoft.com/t5/exchange-team-blog/em...
In ruby your lower level API should support methods with ! syntax that throw and without it that return nil instead:

def get_from_cache
get_from_cache!
rescue NoRecord
nil
end

Then you just do this to not only do it all but only do it once lazily on access:

def record
@record ||= get_from_cache || get_from_database || get_from_api || compute || default_value
end

Be slightly better if ruby supported a proper null coalescing operator like C# ?? and ??= or Perl // and //= but as long as you stay way from "false" as a valid value it works fine.
I’ve been checking the roadmap monthly for a year or two at this point regarding MacOS support. Any inkling of when it will be supported?
Antibody-dependent enhancement. Anyone raising concern was labelled an anti-vaxxer. Hubris is always punished.
Gameboy CT scan – design lessons learned
This makes me optimistic. Why? For the longest time, Google has had a monopoly on internet search. This is unhealthy for the entire internet. Google's declining quality opens a rather large door for competition, and I see really promising alternatives such as DuckDuckGo.

Perhaps this is simply an example of the business life cycle in action. Eventually all businesses crush themselves under their own weight and greed.
For example, JQuery: https://stackoverflow.com/questions/3372962/can-i-remove-the...
A broken leg is sometimes a bad metaphor.

Sure, you'd take them to the doctor for a broken leg, and help them as they get better. I'd leave someone that didn't do this.

But if the person refused to go to the doctor, what do you do then? How do you assess if they are bad enough to try to force them into hospitalisation if they aren't obviously a danger to anyone? What if the broken leg winds up causing abusive behavior (on repeated occasions) - do you stay? If their leg doesn't heal correctly and you have to care for them, can you handle the stress? What happens if you find out you aren't a good caregiver and it makes you hate your life?

I know these examples seem extreme, but it is closer to what folks sometimes deal with when their loved one has a mental illness.
Sounds like headers in general are not necessarily a good idea.

They provide flexibility but at a cost.

I enjoyed Borland Pascal compilation speeds and clean dependencies before switching to Linux. I miss it, together with Delphi.
That's true. At least YT is still better than generic WWW search when you are looking for some specific model or some DIY technique. It's still harder to make a SEO-optimized video than a webpage.
You didn't address half the concerns I brought up. I'll even give you your points on "not being designed to provide long term sterilizing immunity".

You still haven't addressed the anti-pattern of cranking out "vaccines of the month", the environmental impact of utilizing a protein from a natural source in a QC process intended to track pharma batches for multiple doses for every human on earth, the incentive problem that emerges from vaccinations not designed for long lasting, sterilizing immunity in that it's already been acknowledged by Goldman Sachs analysts that cures are not a good business model and that this approach to vaccine making seems eerily in that vein of taking this advice to heart.

Condescend on the DYOR folks all you want. If someone didn't, none would ever get done. I, for one, will continue to learn as much as I can, and will encourage people to do as much thinking for themselves as I can. Funny thing I noticed is half the people who say "leave it to the experts" tend to own stock in said experts.
How is this an example the ‘caste system’?
Yep. Interesting article with interesting science. I don’t really buy it, but I love the idea and what they have done to explore it here. Anything about the origins of COVID is off-topic and a waste of time especially since this article is about the origins of Omicron!
> “What use would a carpenter have for biology?” asked Krill

Well, he might be able to understand why vaccination may be useful for him.

Shouldn't we at least aspire to provide everyone with the basic knowledge needed to make informed life decisions?

> When I poked around, I wasn’t shocked to learn that McKean County — where a school superintendent concedes that math and science education is struggling — also has one of the lowest COVID-19 vaccination rates in Pennsylvania, just 38.1%, compared with 52.7% statewide.
Didn't we do this back in the day for IE?
I am trying to find the 747 polar engine failure. As I recall, it was a cargo flight, the which attract less attention from aviation archivers.
What's the point of TLS proxy?
The location adjacent to a celebrity is always scarce (assuming the dimension is 3D). This give it value, because even though you (an entity) can visit the location for free easily, the owner of adjacent locations are "associated" with the celebrity and this "association" is what is worth money (of course, this value is in addition to the Agglomeration value imho).
Interviewing has become a theater of the absurd.

You get examined on things that won't be useful in 99% of your work.

People put in hours to prepare and game it.

Overall countless hours go to waste to just play the role.

Most times it doesn't even show whether someone can think (what you might see as thinking might be well rehearsed "act as dumbfounded for a while").
Technocratic Keynesianism: a paradigm shift without legislative change
Not all errors or accidents are created equal. As someone else mentioned in this thread the nature of human error is qualitatively different than the nature of seemingly random errors we see with self-driving. Code bugs can produce any scale of error. Humans do no in any given situation have open-ended likelihood of making any errors.

Search youtube videos of Teslas if you haven't seen them yet. The cars will randomly swerve into parked cars, inexplicably steer out of turns, aim directly at medians on the highway. Human errors on average do not equate to this if we want to compare human error "rates" to machine. What is the rate of a random catastrophic error? Machines are way way too high for the foreseeable future, and because of the nature of software bugs they arguably always be higher than humans. The scope of what AI has to be to achieve "general" driving on open-map roads with near infinite variables nearly equates to "general" AI itself.

You can't allow "halfway" monitoring the car. It's all or nothing. It's always monitored or it's not monitored because errors can happen at any time. But anyways, humans aren't robots. Their attention basically not focused if it's not focused completely... multi-tasking is false, and humans already fall asleep fairly easily driving manually. If they have to sit there "focused" but not driving this will lead to even more instances of sleeping or just not monitoring generally.

The numbers are a thought experiment what I mean by effectiveness or mistake or error is just the driver (man or machine) doing something they shouldn't have. Messing up. Humans have very low rates of these mistakes/bad actions/errors. They have very very low rates of catastrophic mistakes. I predict Tesla's won't be 99.anything for a long time. But think of how error-free they have to be to account for the huge domain of roads, signs, weather, terrains, other cars such that when they make their mistakes it doesn't result in disaster... or just "accidents" galore.
I think the author means exactly that type of vacation feels boring.
I know it is strange, but some people feel best when working towards a goal, it is like a drug I guess.
If I go on such vacation, then yes - if it is packed with activities this makes thing better, BUT if you have a small child like me, then you cant do much to exert you energy except doing chores and things I am not good at and I get a bit restless.
If however I manage to work just for 2 hours on something I become a whole different man after that and I can enjoy my vacation better.
I realise that I might be boring to other people by doing so, but learned to accept this.
> Given the low vaccination rate in Sub-Saharan Africa at the time this variant emerged from there, it's unlikely that mass vaccination campaigns drove selection pressure in this case. Far more likely that it was a host jump or a long mutation period inside a single immuno-compromised individual.

Perhaps, but it's my understanding that Omicron was first observed in diplomats that had already received multiple vaccinations. See: https://www.nytimes.com/2021/12/03/world/botswana-diplomats-...
Hilarious. I was so confused at why anyone would name a dog after someone in the family.

I was already running through my head a scenario like on King of the Hill where Hank Hill's father, Cotton, decides to name his newborn son Hank and refers to him as "Good Hank".
Simple: Americans are assholes and Brits are arseholes. Ok?
The entire comment you've written seems hellbent on attributing this person's anger to some specific entity... did you take 5 seconds to ask yourself what the goal of that is? Is the goal to find out what they're angry at so you can invalidate their pain over (what you seem to understand is) a terrible situation?

"Oh you're angry at the doctors? Well doctors can't read the future."

"Oh you're angry at the tests? Well the tests are perfect."

I mean, I don't know why I'm asking when it's exactly what your first comment tried to do. And for obvious reasons they didn't appreciate it... after all what does it add?

-

You think this person doesn't know tests are imperfect?

You think they don't know what false positives and false negatives are?

Or you think they know and it's still a terrible situation, and any article about the inaccuracy prenatal tests would have reminded them of their traumatic experience that at least somewhat involved the inaccuracy prenatal tests, even if the inaccuracies involved are not exactly the same

-

And I mean, let's consider hypothetically they don't know for a second! Or let's say your goal was for the benefit of another reader. You're going to be the one to inform them of these things and then... ???

I mean seriously, someone reads an article that causes them to recall their child's birth which they described as a living hell. I think it's safe to say:

a) the point was not asking HN strangers to tell them why they're upset with the wrong thing

b) they likely understood their situation was not 1-1 with the article's situation

c) they commented anyways because they were venting. And not an off-topic venting anyways, they didn't say "I hate prenatal tests that are false negative" they showed hatred for inaccurate prenatal tests which doesn't prescribe a direction and is pretty fair???

-

And yes I get HN's love this place to be as sterile as an OR, but it's not every day we get an article that has this level of personal implication, so what exactly does anyone lose just letting this person vent without trying to police their emotions or "correct" their anger?

If this was a website about prenatal care it'd be one thing, but posts about prenatal care make up: 0.0024% of all posts on this website. 47 mentions out of over 1 million stories.

Honestly I'm shocked this even needs to be said though. This is all covered under basic social skills, but then again maybe I'm being inconsiderate of the fact that certain personal situations can affect the ability to pick up on non-verbal cues and implicit social expectations

To that end, in the future: Never, ever, ask someone if they wish they had aborted a child they had.

(And before you rush to say you didn't, don't even ask it implicitly.)

If they feel the need to share an opinion on that they will. It's certainly not for you to ask, and even less so for you to ask an internet stranger.
I've previously been diagnosed with BP, ADHD and depression. Tried all sorts of meds. I was never debilitated by these conditions but felt it was holding me back. Several trips to South America, a lot of work on cleansing my body and diet, and I found love for life and a fire inside. I released all my past grievances, reformed new perspectives, let go of strong opinions and learned not to connect feelings with identity, observing them coming and going instead.

Through this I have developed such a love and thirst for life. Each day I wake up and write what I am grateful for. Every day is a gift.... the simpler the thing that I can genuinely feel grateful for (example a glass of water) the great freedom and distance I feel from those conditions.

I feel for those going through this and I wish you the very best.
Could it be as simple as those who have made the effort to get vaccinated are more keenly aware of monitoring for symptoms and are more likely to take the step of being tested to help prevent transmission where as those who remain unvaccinated are more likely to remain untested when symptomatic?

Another poster here suggested that we are seeing the mRNA vaccines causing an immune response on a particular axis and that has caused selective pressure on mutations resulting in mutations such as Omicron, which in turn manifests more symptomatically in the vaccinated.

We have some correlation, but no exploration of causation. Id suggest that twitter thread is jumping to conclusions without considering the why.
I also keep my phone in another room. Helps me with waking up because I need to get up to turn the alarm off. For going to bed on time, with which I still struggle, I tried to set reminders on the phone.

- 10 PM - Stop chores.

- 11 PM, settle down. Means no "active" things anymore, like gaming, HN. I lie down. Reading a book would be best then, watching TV is a bit worse but still more passive. Audiobooks or podcasts get me sleeping then right away.

- 11 PM: Go to bed. Getting up from the couch, brush teeth, go to bed. I think a routine like this is very helpful.
Genuine racists, sexists, and their sort have no greater allies than the ever-present purity inquisition among people purporting to oppose bigotry. What may have begun as efforts to reform thinking in a progressive and egalitarian manner has become the mirror image of the hate-mongering of their opponents. The difference is that the racists attack people who were never inclined to be their allies, and that's why they win elections.
I agree but if he votes with the rest of the conservative wing on Roe, he can and likely will assign himself the writing of the majority opinion. Then, hopefully, and as you say, he will keep the opinion narrow. If he votes with the liberal wing, Roe still goes down but then Thomas or Alito will get to write it.
Rock, meet hard place. SCOTUS will lose what if any integrity it has left. McConnell and the senate did this, first with preventing Garland then jamming ACB through.
I enjoyed reading this very much! Thank you!
"The good news is that the invasive test proved the screener was incorrect. The bad news is that it looks like you've now lost your baby. It was fine though!".

The risks associated with this extended testing are just not worth it, perhaps aside from Down's (from a numbers point of view). Even then, there are many completely gorgeous children and people with Down's .. chances are you'll have a curveball in life one way or another at any rate.

I have two children, one diagnosed with ADHD/ASD, the other likely not too different but too early to tell. Apple doesn't fall too far from the tree. Wouldn't change a thing, other than to avoid the ABA services companies like plague - they prey on your insecurities and you might face financial ruin for possibly no real benefit to the child if you go along with their spiels.

So, to see medical companies exploiting vulnerable new parents who will do anything for their children? I am shocked. (/S...)
Dr. Richard Leakey has died
Here is an extensive step-by-step tutorial which describes in detail how to create and deploy a React-based web app frontend using TypeScript and Redux Toolkit on top of a Node.js based AWS Lambda backend with a DynamoDB database, connect and integrate them through API Gateway and CloudFront, and explains how to codify and automate the required cloud infrastructure and deployment process using Terraform.

The resulting architecture does not require any CORS requests, too:

https://manuel.kiessling.net/2021/05/02/tutorial-react-singl...
I don't think different behaviours between the two groups can be discounted.

If unvaccinated has to be tested to participate in social activities, they'll get tested more often and isolate if they get a positive test preventing spread to others in their group (this assumes that unvaccinated group together somewhat, which I don't have any evidence for besides anecdotally)

Being vaccinated might also lead to risky behaviour disproportionate to the risk mitigation provided by the vaccine - it might be a consequence of risk homeostasis, but the risk has now increased, which skews the bias towards more infections in the vaccinated group.
Does attempting to delete generate an error page of some sort? If so, you could try triggering it over and over again, as quickly as you can, for at least 10-15 minutes. This will cause their error rate to spike, and likely get the attention of their engineering team.
I disagree with the premise that writing concisely is analogous to writing concise code. In fact, the opposite is more likely true.

Why do we still have thousands of poorly written program error messages of the meaningless 'invalid value' kind? Everyone immediately recognises this staccato style of writing common among developers.

Even modern programming languages have terrible compiler error messages. (Rust has made a commendable effort to display readable English compiler error messages.)

All this suggests to me that developers who write their English like their code are writing like a computer, not writing for other humans.

---

Here are two recommendations for writing clear English (excludes fiction) :

Plain English Campaign

This is a campaigning organisation from the UK which promotes clear, easy-to-understand written English suitable for any industry or profession.

Here is their clear, simple and short guide on How to write in plain English [PDF]:

http://www.plainenglish.co.uk/files/howto.pdf

---

GOV.UK: 10 tips for clear writing

I find the tips at the following link very helpful:

https://gds.blog.gov.uk/2019/08/27/podcast-on-writing/

You don't need to listen to the podcast at the top of the linked page (unless you want to). Scroll down the page and you'll find a short description of each of the following tips:

1. Establish ‘The Point’

2. Write it like you’d say it

3. Don’t try to sound clever

4. Show the thing

5. Know that you are not your writing

6. Share your work

7. Read (poetry in particular)

8. Never start with a blank page

9. Know when enough is enough

10. Stay human
Hot take: the current state of anti-racism is increasingly indistinguishable from regular racism.
Good point on the zorashtrians. Nobody speaks about the ‘privilege’ of zorashtrians. parsis excommunicate those who marry outside of their faith. They won’t get a Zoroastrian burial and their children won’t be recognized as Parsees. This is why their numbers are dwindling due to lack of a large diverse gene pool.
https://en.wikipedia.org/wiki/2021_United_States_Capitol_att...
Demands on efficiency are every bit as stringent today as in the '70s. Machines are faster, but we expect them to achieve even more. Clock rates have stagnated, but problem sizes have not.

The failure modes of C and C++ ints are less bad than is typical of construction materials. The common mistake is hiring CS people and expecting them to think and act like engineers.
When I read Scientific American when I was in High School in the 90’s it was a very challenging read. I don’t think any publication outside of a scientific journal is that rigorous anymore.
Did you see this thread posted a few hours before your post?

https://news.ycombinator.com/item?id=29775023
OK, I'm probably going to burn a bunch of karma on this comment, but this is very interesting. For example, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516275/ looks like a legitimate piece of research.

Isn't this exactly what we are doing with the current COVID vaccines? How does one explore this question without being labeled a crazy antivaxxer?
I know this from Usenet days. It's difficult to search early archives these days, though this 2005 verion of the net.abuse FAQ contains a reference. If you can trace that document back earlier you'll likely get closer to the source.

http://www.faqs.org/faqs/net-abuse-faq/troll-faq/
> 2. Your spouse - no trust - lack of compassion.

You can't know that without more context. Things aren't that simple in a tight relationship environment, and it's not some random person on the interwebs that can make out such a conclusion with a mere block of text from the OP.
That's a mouthful.
I have benefitted from the German health care system myself and I stand by my statement.

Governments are not immune against financial considerations any more than the private sector is. For example the transportation ministry/department has a figure at which a life is valued and won’t build a road improvement if the cost/mile exceeds that.