skysight-inc/HackerNews huggingface dataset:
In my experience your body "learns" when you normally eat and makes you hungry/cranky at that time. You can re-train it, and the hunger/crankiness disappears.

For example when I started doing IM (no eating from 7 pm - 11 am) I'd get cranky around breakfast time for the first few days, and then it went, and my most productive time is now 8 am - 10:30 am.

Same thing with OMAD or regular fasting, you can retrain your body into what is normal, and you do gain better focus. You do crash fairly hard around your new eating window though.
> A blog post full of wild speculation

Asking valid questions, though. Is that better to bury one's head in the sand?
Low band 5G has more spectrum allocated, too (well ok, the spectrum was reallocated for phones and could be used for whatever, but it will be used for 5G, because you need new antennas/etc on the handsets to access the new spectrum and who wants to use new spectrum with old modulation).

Some of the new spectrum is lower frequency, in the US former TV channels 52-69 (700Mhz) were reallocated around 2008 and mostly used for LTE, former TV channels 38-51 (600Mhz) were reallocated around 2020 and will be mostly used for 5G. This new UHF spectrum may propigate further and help close some gaps in coverage.
I read it, came back happy to upvote, and saw that it was flagged.

And I wasn't surprised.

That's a wild state of affairs.

.. And it looks like I wasn't the only one.
I could see this case for the likes of Apple or Google, because it's a market where the top two phone platforms together have >99% of the market and there is a strong network effect.

Amazon is the biggest retailer, but they have a hundred competitors of all sizes. If you make it easier to compete with them, they would have more competitors. If they had more competitors, they would get smaller. What else do you need?
You're right, I had multiple tabs open reading different studies and confounded a bit of them, but I'll leave my original comment as is.
I'm confused. Is Dr. Ferguson and Dr. Vonagen's observations about s/sn ratio not decent evidence towards this?
It seems quite good statistically to me.
No, they did not. What they meant was that already Delta is so contagious that only very limited amount of people can avoid it - r0 ~ 6-8 will make sure of it that ~85-90% of people must be immune to stop its spread.

Seasonal flu has r0 = 1.3. This means that it does not affect 75% of the population. The formula is p = 1 - (1/r0) to find out at what level of immunity the disease will die out.

Original Sars2 had r0 = 3, this meant that about 60% immunity level is needed. This is from where to original need of 70% of vaccinated comes from - vaccines do not give 100% immunity so you have to account for that.

Delta messed everything up. With p=85% and vaccine efficiency of 70% (because nobody, except Israelis dared to think about boosters first), you need more than 100% vaccinated - everyone gets is either vaccinated and lucky or vaccinated/unvaccinated and will get infected.
Could this be because they were secretly doing the testing using traditional lab testing machines (as described in Bad Blood)? Maybe that made it hard to prove any specific test was tainted.
> Hence why many sites are banning or censoring comments that are “mean”

Sites have always had terms of service. If you're seeing them enforced more often, it's because we've reached the end of the laissez-faire enforcement experiment for several key large sites; they attempted to maximize what was allowed, and found they had facilitated an attempted coup in their headquarters country, which would not be in their best interests.
I often upvote articles I find interesting enough I want to see a discussion of them on HN. To me it doesn't mean every word of an article is perfect and above criticism, it just means it's IMO interesting and of substance enough to warrant discussion.

In this case I took my time fully reading it before posting it, but not being a biotech person I posted this here also because I was interested in criticism of flaws I would have no chance of not overlooking. But just flagging it isn't that. It doesn't tell me this article is bad, it tells me too many people aren't acting in good faith, so that raises the question why that is.

Trying to turn it around on others by speculating on what they might have done (i.e. why they upvoted it, if they read it), doesn't change what was definitely done (i.e. flagging it without any substantial criticism).
Can you guys share your collection? I'm not a part of this hobby yet, but I'm immediately on board.

Would you be interested in an unreleased "Cosby Show" lego set that was supposed to come out right before he got cancelled?
Fraud means that you lied for personal gain. There is more evidence of her lying directly to investors than to patients.
Sugar: The Bitter Truth (2009)

https://youtu.be/dBnniua6-oM?t=66s
That's not what a "not guilty" verdict means.

The jury didn't find that the results given to the patients were accurate. They found that Holmes was not personally, criminally culpable for wire fraud in those cases. Wire fraud is a crime that has very specific elements, well beyond the question of how accurate the test results were.
Why not build a tricycle instead? Much more stable, not much more complicated, and the parts shouldn't be an issue since you'll have four wheels and two axles lying around already.
Do you have the epic ENRON intern Tshirt in your collection ?
Former Enron employee here - I have some swag I was given when I first started (lunch kit, values booklet, etc. Also have some golf shirts and baseball caps.

Worth anything?
Still seems like fraud to me, they advertised a single drop of blood and they ended up taking blood samples the normal method.
The business model - i.e. how they make money
Once again, just because some dude wrote it down in a book doesn't mean it's a fact. The jury just acquitted her of those charges. Maybe they didn't the read dude's book?
OpenDomain is a non-profit.

Some people contribute years of their time to help open source projects. OpenDomain does it by contributing domains.
Yes, but I’ve only been here for about 2 months. I absolutely hated my previous position. By the time I finally accepted it wasn’t going to get better, I was so depressed and downtrodden that it was extremely difficult to add interviews and studying to my daily workload.

I was pretty quick to accept my current position and I have since recovered from the depression. I don’t see myself staying here more then a couple years. Hopefully inflation will have leveled out by then and I’ll have the energy to put into getting a ‘dream job’. In the mean time I’m enjoying life and learning new things for the joy of it.
What intrigued me about your comment is the reference to a "CD opener". I had no idea!
I remember my dad telling me one day we could see each other over the phone and finding this insanely cool. We imagined it as a sort of mini tv on top of the landline phone.

No one predicted me writing to you from an elevator in Hong Kong and having the speed of interaction under a few milliseconds. And now that I Skype my dad across the ocean, it seems like a very secondary and minor feature of the internet.

Whatsapp alone changed how we interact with far away family as if we never left.
Well well… I imagine we’ve crossed paths on eBay before - too funny.
What always amazed me is they had nothing… nothing that could do the thing they claimed. To the point they used competitors machines to produce results.

Pretty amazing.
Did you get the MSCHF fucked company toys? The tiny Theranos machine is adorable.

Like you, I collect fucked/defunct company merch, tho my collection isn’t just fraud related, I’ve got Quibi merch — most of it is. I’ve got MoviePass, Fyre Festival legit merch with tags, Ozy Media was a recent one, Enron business cards, Arthur Andersen tote bags, Worldcom mugs, etc. I’ve even got some old Internet Explorer merch, because it’s kitsch!

What is your favorite piece?
Why not a stock certificate :-)

https://www.apmex.com/product/50847/enron-corp-stock-certifi...
Ivermectin is not only used for deworming. Low information comment.
Oh yes, they had cholesterol (and they still do)... it's just that they CAN be a part of a healthy diet, while breakfast cereal arguably can't no matter how many vitamins you add to it. You'll still find plenty of egg white only things out there in the dairy aisle or at your local diner... since it was the dreaded yolk with all the fat (and vitamins and cholesterol) that was supposed to be bad.
Hi Bill,

You mention "Product Designer (Senior, Lead, Principal or Director)" above, and I've got a friend (ex-Bing) interested in a Senior/Lead role. However https://duckduckgo.com/hiring doesn't mention any design positions. How can I get y'all connected?

Thanks!
Well depends on where in the world you are. Preferably something in person of course.
Only known video of the Chirodectes jellyfish
https://archive.is/nbUkO
https://en.wikipedia.org/wiki/Chirodectes
Just out of curiosity, how does one prove provenance?

I’d think the only way is to be the original owner (ie proof of employment at the company), but even then, given such a hot marketplace it would be super easy to just purchase and resell knockoffs.
They’re a relatively high source of dietary cholesterol. When we first figured out that serum cholesterol is correlated with cardio problems, we basically assumed that dietary cholesterol must be bad. We’ve since figured out that dietary cholesterol is a much less significant driver of serum cholesterol than one would naively assume.
My layman's interpretation is that she willingly defrauded investors but did in fact deliver test results to the patients, albeit at a lower quality level than you would expect in the industry.

I think in the HBO documentary they say the unravelling started because of FDA complaints on the bloodwork being sub par. But I think you can't jail someone for 120 years because they did a shoddy product. Maybe the prosecutors simply went for the biggest bang for their buck?
Then let me offer two informal "substantial" arguments. It's too long to question every point.

The author argued in section "weirdness 1" that the phylogentic tree implies the omicron strain is directly related to an ancestor genome from Spring 2020. I have the following concerns:

the tree is based on https://nextstrain.org/ , a database initially introduced in 2018 [1]. This is a great data source. However, for COVID, nextstrain naturally bias towards the more viable biosamples. In other words, COVID strains in wild animals such are going to be underrepresented, if represented at all. And if so, the large sequence divergence is surprising but not a direct indication of lab leak. The author can supply with a rough overview of sequencing sources of nextstrain to counter this. Or better, it would be good if the author can compare with, or cite existing literatures, phylogenetic trees of other epidemics and demonstrate that the sequence divergence is much larger than what we would expect from wild animal reservoir.

"weirdness 2" has a stand, but it should be accompanied by silent/functional mutation ratios in other COVID strains since synonomous mutation could be not entirely silent if translation efficiency is affected (correct me if I'm wrong).

Briefly on one other point, "weirdly it's exactly mice, not other animals": we use mice as lab animals for a reason. They are somewhat similar to human in terms of physiology. Therefore we can expect that they could be more prone to COVID infection, aren't we?

editted to add one more sentence: from a peer review aspect, this blog is beyond terrible and I'd probably have 10 major conerns listed if it comes in as a PR.

[1] https://academic.oup.com/bioinformatics/article/34/23/4121/5...
I've got two beer glasses from WeWork that say "glass half full" on them. They make me laugh every single time I see them.
Shirley Exception: People falsely think there are reasonable exceptions to laws
I have no idea if it is true in this specific case, just from what I know of Indian acquaintances who also go by Sunny. Very well could be he picked his own Englishized nickname to be Sunny because he was born on a Sunday, or any other reason.
Amazing to meet another fucked company collector! I thought this was something only I did, genuinely.
My colleagues and I have developed a technique that addresses a lot of the issues Mike discusses in that link. In this blog article explaining the technique, I included an example that nearly matches Mike's hand-coded assembly from your link: https://blog.reverberate.org/2021/04/21/musttail-efficient-i...

In my experience, the weakest point of modern optimizing compilers is the register allocator. As Mike mentioned in his link, in functions with loops that contain complex control flow, the register allocation just falls apart. Too often you see the register allocator forcing a spill on the fast path that was caused by code in a fallback path. You can sprinkle __builtin_expect(cond, 0) on all your guards until the cows come home but the register allocator still sees a big complicated connected graph and optimizes the whole thing together.

The technique described in my link above works around this by basically forcing a specific register allocation at each "operation" boundary, putting fallback paths in separate functions entirely (as much as possible), so that they will be considered totally distinct to the optimizer. This isn't a perfect solution, but it helps a lot.

My overall view is that you can rarely beat the compiler in straight-line code. It's mainly in loops with complex control flow where the compiler's code quality suffers.
Location: Barcelona, Spain

Remote: Yes

Willing to relocate: No

Technologies: React, TypeScript, NodeJS, NextJS, GraphQL

Résumé/CV: https://github.com/agustif/me/blob/master/cv.pdf

Email: me@agusti.me

Hi, I'm Agusti Fernandez, Fullstack software engineer, most familiar with frontend as I've a past as a UX/UI Designer. Would love to find a nice place to work. Please send an email if you think I could be a good fit.
Isn't Meta still trading under FB, leaving you with FAANG?
They had a fully functional lab though, it just wasn't using Theranos' devices.

This is what they did to Wallgreens, they sold them on the idea that they would have theranos machines in-store, but instead what they did was do IV blood draws (calling it a comparison check) .. and then would just process the samples the same way as everyone else using standard equipment.

People were getting good results because Theranos was using machines from Siemens in their hidden lab.
They’re mostly older folks. Not tech savvy. I doubt it’s the twitterotti.

Not sure where there fear is from. Part of it is simply not wanting to be racist, but not knowing what racism means (as a consensus definition).

The author mentioned going from most left wing to right wing without changing opinions. That’s what’s going on here … the definition of “racist” is vague so it’s better to move as far to the left as possible.

I think it’s the uncertainty over what is acceptable that’s causing fear.
Eh, not really, but it’s unlikely I could find a job where I would be. It really was a mistake to become a professional programmer.
What this guy said.

Don’t you remember the egg whites only phase?!
There's a podcast called bad blood that goes into detail how little it worked.
> who fact-checks the fact-checkers?

Fact checkers are just a name like antifa, to make it sound like if you are against them, you are anti-fact and therefore a crazy person. Smart play with naming.

Fact checkers are just "narrative control".
The Epic Rise and Fall of Elizabeth Holmes
>The US government calls him a Russian asset.

Exactly like Putin. He likes to call all of the journalists he locks up foreign agents and the US always condemns him.

His less intellectually inclined supporters are generally of the view that their government can be trusted to make these kinds of judgements and that the journalists really are foreign agents.
Flutter is cool, it has desktop support although it's still under development.

https://flutter.dev/multi-platform/desktop
"Scaling too fast" has definitely a better vibe to it than "found guilty" :)
That means you are pushing your limits. Don't start with a full day fasting. Start slow by doing some form of intermittent fasting or time restricted feeding. I would say go for having early dinner and a late breakfast to begin with. Once you are adapted to log hours of not eating, skip one of the meals in the day, depends on your situation but the easiest one to start with is skipping breakfast. Then you can slowly work your way to full day fasting.
New Year, new release of UbuntuDDE 21.10
You just reminded me to set up MFA on my root account so thanks!
Traffic and parking concerns are legitimate gripes that I’ve heard (and I’m inclined to feel myself).

I don’t care who lives next to me, because my interactions with them are limited to kindly waves as we pass on the sidewalk.

If I couldn’t park my car anywhere near my house because the alternative timeline neighborhood had twice as many cars because it had twice as many kitchens and exterior doors, I’d be less satisfied with my neighborhood as compared to now where the parking is generally adequate except on street cleaning days. That’s got nothing whatsoever to do with who the other car owners are, how expensive the other cars are, or how rich they are.

This is also some of where “each new residential lot needs X feet of frontage and Y parking spaces per unit” zoning laws come from. It’s not just “keep the poors out” (although that may be a secondary motivation for some).
Same, I'm one of them. I now donate to the developers of the *aar web apps instead.

I had Netflix and Prime till recently in an effort to promote the defragmentation of streaming services as a show of unity but, its getting worse. And these guys do not need my money while the service they provide gets worse and worse.
copies of the podcast not published by Rogan, on Youtube, were removed.
I deleted my AWS account yesterday. It is obviously catered towards large organisations - very complicated tools and pricing that I couldn't really fit into my use case. I tried to just shut down the services that were using money but wasn't even sure I had found them all so I just closed the whole account.

I don't even like the idea of any of this stuff. I want to run my own little raspberry pi server or whatever, it seems much more fun and startupish than aws, which appears to be all of the corporate stuff I left (AIMs etc). This is funny because I remember AWS being thought of as great for "just experimenting with stuff".
I might be wrong but my understanding is that the patients' blood was tested on legit equipment so they did get valid results. It just wasn't using the Theranos technology. So investors (and Wallgreens) were defrauded because they were mislead but the patient experience was valid (since the results were correct and from proper equipment).
I could imagine having a little ‘altar’ of failed company swag on a shelf in your office could be fun and motivating in a way.
Fauci himself shared these concerns during International Consultative Workshop on H5N1 Gain of Function Research (2013):

https://youtu.be/4fsVN34LRb8?t=7229
Yeah the lying isn't cool at all. Totally agree.
Maybe. I haven’t read the article yet. I’m one of those comments-first kind of people.

Definitely intrigued, now!
It also cites Science, The Taiwan Times, and Forbes (shrug).

But more importantly, it's well reasoned. It's not "wild speculation". It's learned speculation based on history, opinions of experts, and independent sources, synthesized with deduction.

I understand the reflex to push back on claims of conspiracy. I find the mainstream meme conspiracy theories (flat earth, 9/11 was an inside job, etc) to be somewhere between laughable and terrifying. But this is a unicorn among conspiracy theories: both the initial conditions are plausible (that this was an accident, of a kind that has happened before, not a nefarious pre-planned event with dubious benefit), and the conditions of the conspiracy are plausible (the set of people with positive knowledge of a given leak would be quite small, and their incentives to keep it secret would be strongly aligned).
Only 3 left in stock!

Also I love that website. As a recent casual collector of paper currency. I never thought to buy some old stocks/bonds.

Edit: it’d be hilarious I’d the Enron stock was fake
Didn't do anything in particular, dunno. Maybe all the canned sardines in water I was eating/drinking the broth from delivered enough sodium? I didn't feel ill or anything like that.
After she recovered from polio did she then get the polio vaccine?
> I am a collector of swag from large companies that have collapsed due to anything from mismanagement to outright fraud

That's a really cool collection! I always find it interesting to learn what obscure things folks collect.

> any authentic Theranos gear

How do you tell if it's authentic? If I was a collector in this area, my big concern would be that especially given that the market is hot, someone could just look on ebay for images of branded products, and then make replicas of them by passing the same logo onto promotional printers.
The First Be Shareholders Meeting (2000)
> it is impossible to avoid a diet in western society that relies on high quantities of sugar as a lynchpin for mass produced food.

I live in the western society you describe and enjoy a diet with no added sugar.

How?

I prepare my own food from fresh ingredients.
What's an example of a fakery that doesn't harm innocent parties? If you pretend a product (or a feature) that doesn't exist exists, then at the very least a competitor is unfairly harmed.
I know it's easy to get lazy about checking your AWS billing dashboard but I do it once a week - you can set up alerts and whatnot but I find it easier just to go look at the current usage to make sure nothing has gone awry.
"Where did SARS-CoV-2 come from?" is a scientific question. It certainly could have ethical implications, granted, but that does not make it not a question suitable for scientific inquiry.
One word: frictionless. Zoom is by far the easiest thing to onboard for a random person. My mom struggled to understand Skype account creation wall.

I work in a megacorp that forbade Zoom to the profit of our already well established Skype and MS Team.

Fast forward to last week, a team of "digital innovation onboarding" claimed huge victory against our rotting process by finally getting Zoom approved... finally lol.

And the worst is I want Zoom too: easier to interview candidates, meet client and trainers, contact universities etc.
I’m trying to give up sugar now and it’s worse than giving up smoking so far and almost exactly the same feeling for me, inability to sleep, joint pains, headache, disorientation, mood swings and so on (obviously hunger too). I had a small amount of mass produced bread with stew for dinner and the bread was insanely sweet in a way that can only be described as like a fix for a drug addict - pure pleasure - but it was so extreme that I think any bread is out too until I’m able to break my addiction.
Primarily it's ranchers and farmers globally who want to get paid to add carbon to their soils by adopting more soil-friendly practices. This is a rapidly growing market as more companies are looking to offset their emissions. There's also a good deal of growers simply interested in learning about the climate impact of their practices, or soil researchers studying the carbon impact of various practices.

Current soil carbon measurement methods are very cost- and labor intensive, so our in-situ spectral probe will make these measurements much more accessible.
Small Web: <html>Party like it’s 1999</html>
I feel the exact opposite. The investors that actually did their due diligence ran away from Theranos. I feel no sympathy for the investors that bought into it. I do however feel tremendous sympathy for the patients that received erroneous test results.