skysight-inc/HackerNews huggingface dataset:
Valdenafil (Levitra) has shown some effect on ALS [1]. Coincidentally, the related sildenafil (Viagra) was identified through computer-aided research as a drug of interest in Alzheimer's prevention. [2]

1. https://www.sciencedirect.com/science/article/pii/S096999611...
2. https://www.everydayhealth.com/alzheimers-disease/viagra-may...
Merry Christmas! Frohe Weihnachten from Austria!
So... entry no. 8717638186 of "Chinese person tries their hand at An Western Business"?
> the difference between the approach from Google and Apple is that in one case (Google), we have a tech level blockage

There is nothing stopping Google from inserting code to scan everything on your device. They can stick it into the binary blob of closed source Play Store code, and you would have no way of knowing it is there.

Google still does scan everything in your online account and has been doing so for the last decade.

Apple has backed down from even doing that for iCloud Photos.
Trisquel GNU/Linux
Yeah, my Apple machine until June this year was a 2015 MBP and people were willing to pay almost full price for it until the M1s came out.
Ask HN: Do you validate your ideas before start coding?
I could not validate any of my startup ideas, most people do not respond, from those who respond I get inconclusive results. Should I still try to validate the idea before coding or just create an MVP and see how it goes? What are your thoughts?
I get a portion of the server fee on either AWS or GCP.
This is flawed. Early retirement and balance are not mutually exclusive.

Early retirement requires doing things a little differently than the average. Luck is always a factor, but you want to stack the cards in your favor.
Crăciun fericit!

Happy holidays to all HN-ers and to their close ones.
Did you read what you wrote? You assumed and implied that I was _scared of JS_ without asking whether this was the case, then called my response unusually defensive. Let's not sweep it under the table.

Your original reply was really uncalled for. Now you're back to some combination of hand-waves and missing the details (which self and others have shared up and down the thread already).

Really, a more respectful, thoughtful approach is merited.
Related past discussions:

* "Ask HN: What's your latest failed side project and why?" https://news.ycombinator.com/item?id=22397720 (222 comments)

* "Ask HN: What's a side project you built to make money that hasn't?" https://news.ycombinator.com/item?id=25580637 (582 comments)

* "Ask HN: Failed project you spent 15 hours/week for 5 years on?" https://news.ycombinator.com/item?id=27838479 (74 comments)
FWIW: given the extraordinarily complicated mechanical design, merely reaching orbit is the "easy part". The real imagined disasters won't happen until the mirrors assemble.
Sure, the fab size is part of the story, but we have also seen a general tendency for efficiency from Arm chips and the reason that they are used in mobile devices. Apple has also been willing to spend money on larger caches and wider buses in their SOCs to remove bottlenecks. Finally, Apple tunes the processor performance to optimize for processes that Mac OS uses a lot. That is possible because of their tight vertical integration and I have not seen on the more heterogenous Windows/Linux + Intel environment.
It is an interesting point. Yes, Facebook is a private firm and can do whatever it wants. But municipality is not. We must either ban public agencies from using such platforms or make them accountable to the sane standard as government
This is a decent comparison. Metaverse is going to have most of the same issues with eyestrain, even more motion sickness and bulkier headgear. It might be a fun curiosity for some but it won't gain the mainstream appeal that Facebook has (or at least once had).
Looks like that's only on Nightly? I'm glad there's a workaround, but I'm not missing Redirector quite that much.
I have no idea how you can spend a few hundred thousand dollars a month while still working hard enough to maintain a high growth rate, which I assume is at least full time. I also cannot fathom making that much (or really any solid amount of money) and spending it all. Why no t put a solid chunk away in case your business goes belly up and you want to retire to a beach?
> I have written licenses to make GitHub hesitate before using my code as input to Copilot

I thought the solution was to treat FOSS as CC0 (public domain) [1], not create yet another license nobody's going to care or use.

CC0 is probably a better license for most FOSS & probably close to what happens in reality (sans a few exceptions) as TikTok and Copilot examples show.

[1] https://creativecommons.org/share-your-work/public-domain/cc...
GraphQL is typed.
I noticed this as well. A lot of my coworkers had given up by day 4 this year.

I decided to go outside my comfort zone and do it in a language that I don't work in. (I work primarily in Ruby, did it this year in Elixir.)

I had a blast honestly! I was a great way to learn a language and get some daily practice in.
The arxiv version isn't very different from the published version, if you end up facing a paywall: https://arxiv.org/pdf/1801.09488.pdf
Db2, Where Are You?
If this headline bothers you then go help the open immersive web become the actual metaverse.
It was clearly in the dudes vibe, nor were they cool enough to hide their ego's many disappointments, like Jack does by being pseudo anonymous and pretending it's part of an enlightened calm. If any of these people were as enlightened as they pretend, they would take the money and gtfo, but truly they are ego derived demons.
At some point drift in language will change the definition of "social media" from the former definition of trying to profit off users self-generated content, to the modern "in practice" definition of a for-profit heavily politically censored propaganda channel.

So, no, under the old def HN was never about becoming trillionaires by selling our accts to google or whatever. And under the new definition HN has intense political leanings but is still primarily technical in nature and doesn't censor as much as Reddit or other fundamentalist or inquisition like as sites.
Spoken like someone toiling away at something your great-grandpa had a solution for.
I sometimes convert pages to a single HTML file with SingleFile[0] which encapsulates all external assets into a single page. I have a small collection of pages which I can browse offline, and also have them for posterity incase they suffer from link rot.

[0] https://addons.mozilla.org/en-US/firefox/addon/single-file/
Being a new parent, I've read a lot of parenting books this year. One of my favorites was No Drama Discipline.

Having grown up in an authoritarian, Asian, tiger-parenting style, this book opened my eyes on a more gentler, warmer way to handle kids. I hope I can practice the methods in the book.
I'm having great results with Kagi as well. I actually forgot I signed up for beta a few weeks back until I saw this post; and started testing it out this morning. Thus far, I'm quite impressed - similar sentiments to what you have outlined.
I'm banned from Instagram and i can't create new accounts because they banned my phone number. So if i want an instagram account i have to buy another number. No way. I can still live without instagram, but this is the way Facebook inc/Meta do business.
For me Meta/Facebook/Instagram/WhatApp have to die!
There's quite a lot of small providers left and thriving - I've recently migrated from Gmail to mailbox.org, set up inbox encryption with my own key and can't be happier about it.

It's not as feature-rich as Gmail, and webmail with your own encryption key is not usable, but desktop (Thunderbird) and mobile (K9 mail) clients fully cover my use cases. Cheaper than Google Workspace, too.
Tbf its hard to find specific things/tweets you're looking for on Twitter even if you do have an account.

At least that's how it was until I stopped logging in about a year ago. But I can still access linked content. On mobile, I just have to paste the url into the browser address bar and it works.
メリークリスマス！
Show HN: Learning language while travel dating
Similar deal with Alzheimer's.
I built OneKeynote.com - the idea is to create podcast streams of an individual you like to hear, across all the various podcasts they go on.

My original motivation was hearing Chamath speak on Kara Swisher's podcast and I loved him. I wanted to hear more of him but realized the only way to do so was to search his name. This was fraught for one big reason, many, many podcasts include his name in the description, even if he isn't a guest (ex try searching Elon Musk!). So I built a quick site and used ListenNotes.com to create custom feeds. I started with tech personalities since that is my area of interest and everyday I would conduct a search on ListenNotes and add to the custom feeds.

ListenNotes does allow you to track who subscribes but it's inaccurate. I did see people start to subscribe to various feeds. However it was very hard to receive feedback. The other problem is it was really time intensive. I would spend about 30 minutes each morning going through all these personalities trying to find new episodes. Eventually I cut the time down as there are some people that don't go on podcasts very much (ex. Andrew Mason) and some people that are on podcasts a lot (Harley Finkelstein) so I adjusted how often I would search. 20-30 minutes might not seem like a lot, but I have a full time job, a family, other projects. My end goal was to insert ads into these feeds but never got the traction to get there. I eventually stopped updating the feeds and I should update the site to reflect that (although the site doesn't appear to be working right now anyways).

I still think this is a good idea but there is probably a better way for it to be done.
It's technically a recurring donation too if you want the current versions, for €20 you get 1 year of updates.
Psychological Warfare Subversion and Control of Western Society [video]
did you read the article? unless the author is outright lying about his private correspondence with people who work on TV shows as a result of his tweet, he is certainly not the only one who is bothered by this stuff
If their goal is independent governance and not needing outside funding, tying themselves to Apple makes plenty of sense.

Android users don't pay money.

That's a slight overgeneralization of course, but when you look at stats showing Android having a massively larger share of users than iOS, you need to realize the vast majority of the user base will not spend money on a service like this or any others for that matter.

If you narrow it down to people who regularly spend money on apps, iOS is clearly the platform to go with.

And using iCloud means one of the biggest dangers to their financial independence is gone: Having to pay for exponentially more storage to go with exponential growth.
I'd like to see something to make it easy to address the case where you are doing #1, but your provider does unilaterally kick you off with short notice for some reason. The email equivalent of a bug out bag [1].

This would be something that provides in a single package an SMTP server, an IMAP and POP server, pre-trained spam filtering, and maybe a web server with a web-based email client, and a simple setup program that asks a few basic questions such as your domain name and configures everything on your end and provides help for configuring things elsewhere (such as with DNS, such as telling you what to put in your SPF and DKIM and DMARC records).

This is meant as something to handle your mail during the time it takes you to find another provider. It is meant to be something you can quickly install on a VM somewhere, point your MX record at it, get a Let's Encrypt or similar certificate for it, and not be losing mail while you are between providers.

It should have a quick start guide that includes details on signing up and getting a Linux VM up at major inexpensive VM hosting places. Amazon Lightsail, Hetzner, and such.

It should make minimal assumptions about your Linux environment. Probably it should not use the SMTP, POP, and IMAP servers that are packaged by your Linux distributor. It should use minimal servers that are written specifically for the emergency mail kit.

[1] https://en.wikipedia.org/wiki/Survival_kit
> Sending your mail yourself is the real hard part

No, having quality spam and fraud filtering, and quality security, that you host yourself, is by far the much harder problem. I would argue that outsourcing your email to Proton or Tutanota is not running your own "artisanal" email server. By the way, even with those email providers, I still have terrible spam and fraud emails getting through filters that I never would have seen with my GMail.
Both my wife and I are really careful about covid, as she had asthma. I'm double vaxed and she is triple. Came down with COVID 11 days ago with symptoms similar to what everyone is reporting here.

What's really annoying is that my anti-vax relative and his family, who we have been in close contact with, have had no symptoms yet. Not wishing they get the virus, but I imagine it will only entrench their anti-vax views.

In fact it's made me question the effectiveness of the vaccines. I'll still get boosted.
But it’s one of those things where you might change your behaviour or priorities if something becomes possible. In this case, having all day battery life on a laptop while also having maximum performance.

Same way we started using laptops for all our work. Desktops are always more powerful in absolute terms and cheaper to boot. But most people don’t even buy desktops for home use.
Cash is the result of cash flow. Free, because tgat is "surplus" created by a business that can be used freely for whatever.
“The First Salute” by Barbara Tuchman, her last book. It’s a deep dive into the politics, personalities and execution of the American revolution. The author is adept at finding the crucial stupid choices that lead to strategic collapse, often driven by pettiness and blindly following orthodoxy. https://en.m.wikipedia.org/wiki/Special:BookSources/03945533...
I launched ByteVitae (https://bytevitae.com/) a couple of years ago, got a decent launch here and in Product Hunt, a bunch of users the first days ~3500 and a steady influx of users over the following months. I didn't know how to convert most of those users to clients, didn't talk to them, lost all interest after the initial launch and moved on after an amazing -26€ in benefits :P

I learned so many things and was such a fruitful ride that for me it is far from a failure. But on the business side, definetly a complete failure!

Even wrote a little post mortem at the time: https://vilva.io/blog/1-year-of-building-reflections.

Lesson learned: Talk to your users. Don't neglect the business/marketing side, specially if you are a techie who loves to code. Talk to your users. It is a marathon run, forget about the overnight millionare launchs, the launch is the "easy" part, growing steady from there is the real challenge. Talk to your users!!
I wonder at what point I’ll be a digital outcast. What will that look like? Will my wife just sit on the couch and only message me through Facebook? Will my 3 friends I’ve known since high school not send me a text message to get together to play tennis and organize virtual tennis on Meta and not invite me?

I think more likely is that this concept is overhyped and fragile. Maybe you can think of something I’m missing here that not having Meta is causing ruin in my life for?
He also gutted the car before blowing it up so I'm sure he made some cash selling those parts.
I'm sorry, but suggesting that I move to a no-name chromium fork maintained by one person because I miss a Firefox extension is absurd. Perhaps I should also leave my country because my local grocery store doesn't carry the cereal I like.

> why do you just take it?

Must be my insatiable masochism.
I was a regular at the options trading subreddit. Lots of questions about how to modify strategies kept coming up (I also have been thinking about it for a while) so I built https://putcalltheta.com.

Got some buzz when i first announced it but things went cold after that. I still get a few user signups occasionally. Need to do some work on it but my mind is wandering off to other projects.

Edit: lessons learned
1. I probably should have had a mobile version of the webapp at launch.
2. Marketing is hard
It's fun to see someone else describe the tokens for votes model. I've been working on my first 3D game trying to think of how I would support it if it's OSS while giving players direct input about the direction and what's implemented. Definitely a pipe dream for me right now but I'm really hoping I can manage to get to a state where that's a problem I have and people to collaborate with on solving
Agreed! Super spare in the best way
I'm thinking of busy British A roads going from 2 to 1 lane, usually the last merge point is at a standstill. I've witnessed insanely aggressive behaviour by drivers trying to block others' merges.

My driving instructor always told me to behave selfishly, because "courteous" driving (flashing lights, slowing down, waiting for someone to emerge etc) is unpredictable by comparison! Courteous driving becomes its own form of aggression when another driver misunderstands.
I think a lot of americans enter adulthood only exposed to "classics" as older english-language works. The prose and especially dialog in those doesn't flow naturally to contemporary english speakers so feels a little difficult or stilted. Familiarity with it needs to be earned before making confident aesthetic judgements.

For the russian classics the translation trend for decades has been a little more terse and less ornate sentence-by-sentence. Which I think flows naturally and makes it feel more modern to contemporary english speakers. This often surprises people! But the russian classics can be a more fun, modern-feeling read than the english ones.

It's one of the advantages of translated works. They can be continually retranslated into the target language as its vernacular and cadence changes. Same-language works are stuck forever with the dialect of the time, and "paraphrases" into modern vernacular are met with much more skepticism than new translations are.
Why isn't SpaceX doing this?
Feliz Natal HN!
Spying by tapping into unencrypted traffic on undersea cables was done briefly during the Cold War. Now governments encrypt all their traffic so you won't get anything useful.

https://en.wikipedia.org/wiki/Operation_Ivy_Bells?wprov=sfla...
And that's why you probably should have had a separate account for running your business. I don't use Facebook for anything except some of the groups that remain there and which are relevant to my hobbies. Strong opinions get you suspended because there will always be someone offended by what you say.
>This is not directly about the big providers making it harder and harder to send them email, although that doesn't help. It's because a quality modern email environment is big, complex, and takes a lot of work to create and keep running.

Gosh...when people forget how to be a admin...

>takes a lot of work to create

True

>and keep running.

Not true
Sorry for your banishment. Now you're a lifetime member of the lost and banned.
> I don't blame the author for using the even-handed examples

This dude had to cherry pick harder than an industrial farm machine so that he could all but ignore the elephants in the room.
Awesome. I had this idea for search result pages. I'm going to implement that into my personal dashboard this week.
The xkcd hover-over text sounds almost like it's describing containers:

> The Python environmental protection agency wants to seal it in a cement chamber [...]
Merry Christmas and Happy New Year!!
"There's a big difference between making it up and having a hunch from reading a bit" - this is the laughable part, because they state a number in the article, so clearly a BIT of reading was the most that was done. Ha. If you're going to just throw out a random but plausible number for your argument's sake, you grab it from the article, if you've read far enough to see it.
The comparison with the imaginary numbers is not the best, because the imaginary numbers are as real as the real numbers.

While the real number 2.0 can represent the scaling of a vector by 2, the imaginary unit is the rotation of the same vector by a right angle.

Any oscillation is equivalent with the projection of a rotation on an axis. Because it is easier to make computations with rotations, all the calculations for electric circuits use rotations to model the oscillations, therefore they use imaginary numbers.

This name of "imaginary" numbers should better be abandoned, or at least their meaning should be much better explained in school, because they are not some mathematical abstraction used only in seldom cases, but it is almost impossible to design a device that does not use rotations either in the actual space or in an abstract space, thus needing imaginary numbers for mathematical modelling.

On the other hand, string theory and a few other theories that are explored by some physicists are completely artificial mathematical models about which nobody has proven yet that they have any relationship with the real world.
Merry Christmas to you all. Incredible!!

P.S Wish the next iteration allows for multi touch!
If you're banned from the public library its not a big deal.

If your voting site is moved to the library, then it becomes a big deal.

This became an issue in my state (or maybe larger area) WRT convicted pedos and similar convictions being able to vote, being legally barred from being within X feet of schools which are open, and voting sites being at schools.

Solution was the kids get voting day off, which hopefully will increase voter participation if someday everyone gets voting day off.
Generating 3.998 Tredecillion unique Hallmark Christmas movie bingo cards with R
Merry Christmas from India
Generating 3.9986e+42 unique Hallmark Christmas movie bingo cards with R
Haha I have the same experience... I have given up trying to send emails to t-online, but every other email-provider accept emails from the server I manage. It sends a few thousand emails per day.

A few years ago we had problems, but then I realized some of the emails sent from our servers had non-ascii characters in headers (subject, from, to) which caused email-providers to distrust our server. Using encoded-words syntax ("=?UTF-8?B?" + BASE64(text) + "?=") fixed that problem:

https://en.wikipedia.org/wiki/MIME#Encoded-Word
Been running my own mail server out of my house for about a decade. It has been glorious. I have always paid for 3rd party spam filtering, both inbound and outbound. Inbound and outbound through a 3rd party helps reduce the attack surface at my house.

My users do not need webmail and I do not offer it. Calendars are done in local clients and shared through invites.

I went with DC powered equipment, with battery backup on the input. My internet and email can stand at least a 24 hour power outage. Its also all solid state and no fans, no moving parts. Its been very reliable, though I do replace the batteries every couple of years. I'm probably over due for hardware updates at this point.
Funny how a joke gets it‘s own Wikpedia article but so many things worthy of one are deleted by the editors due to a percieved „lack of notability“
I would also recommend The Color of Law. Its about how federal, state, and local governments gave rise to and reinforced neighborhood segregation. The content can be a little dry at time, but lots of interesting data and history.
I’d be very careful how much you read into this because it’s begging for confirmation bias.

There’s also a difference between working remotely and being thrown into working remotely at the last minute during a pandemic with no prior experience. I’ve been remote for the last 10 years and the vast majority of problems you mentioned get better over time if you work at it.
For software engineering, four hours of actual work per day is probably average even on-site.