skysight-inc/HackerNews huggingface dataset:
> Can you explain how it increases the breadth of antibody protection if the booster is exactly the same as the original shot?

It's complicated! The short answer I gave elsewhere: B cells aggressively replicate and mutate in response to pathogens, and those that match are selected for. Repeating this process gets more B cells, but also broader varieties of resultant antibodies matching not just the original pathogen but things that are close to it.

> Is there any way to know whether that increased breadth of antibody protection isn't coming from a post vaccination exposure that wasn't tested for not tested?

Yes. We collect plasma from people, and then test it against a variety of variants in assays. We have plenty of old plasma to do this with.

Indeed, there's some evidence that many people who were both infected with SARS-CoV-1 and subsequently vaccinated against SARS-CoV-2 may have exceptionally broad immunity to coronaviruses, not isolated to just SARS-CoV variants but also to wild-type coronaviruses circulating in animals and human coronaviruses causing the common cold.
Well, yes, the spike protein induces an immune response. That's the entire purpose of using it as an antigen in a vaccine. If you don't see the daylight between that and your original claim that 'saturating the body with spike protein' which gets uptaken in tissue in the heart as metabolic substrate which then results in myocarditis, I don't know what to say.
I feel like this too, but only when other people are at the counter.

When I’m at the counter the whole thing never seems to take more than a few minutes. It’s always quick, and smooth, and I’m out of there, seemingly, in no time at all.

I desperately want to know what other people are saying or doing at the rental car counter.
> When have we vaccinated to prevent infectious disease induced side effects excluding morbidity.

Whenever we vaccinate to prevent mortality; generally we vaccinate to mitigate both morbidity and mortality from a disease.
If you're asking how th jvm might do it, I can assure you I do not know. If the question is "can this be a language feature" then I say, surely it can be.

A language that supports static analysis and can disallow dynamic dispatch would do the trick, no?
Here are answers to some earlier questions, so my situation may become a bit more clear:

“Tell us more about what you want to do.”

It didn’t seem on-topic to mention goals and such in my original query, so here is a short list of software goals and answers to a question above:

creating a “killer app” : Since the 80’s. many many tries.
was lucky enough to work on CineLook for several years,

synesthesia: the merging and mixing of different types of media : this has been a fixation of mine for decades

making UI’s that look good AND are easy to use

data visualization: good data visualization can really help

game development: my first app that sold was a math game

. . .

“Do you have anything you want focus on or do you pride yourself on being a generalist?”

It seems to me that AR will become the de facto standard for UI/UX, and most software will need to adapt to that new metaphor. That includes multimedia and musical software.
It would be great to help out in that area somehow.
In the 90s I wrote lots of in-house tools, which required me to think like a generalist. This sort of work is fine for me but I would place it as a second priority desire in a perfect world.

. . .
“Architect, team lead, or pure development of a system from day to day?”
Have led a team on a few occasions and was able to handle it but it would depend on the team. Have done pure development for decades but it doesn’t have to be the only thing I do.

. . .

“And business domains that you’re especially familiar with or interested in?”

Anything involving new uses of media and trans-media. Some things being done in aerospace are very appealing, such as the concept of a 3D-printed rocket. Financials are interesting also, as would be supporting research in astronomy, physics (especially superconductivity) or perhaps infrastructure. Education is also a great field to do work in.

thanks once again for all the info and support!
As a tech director, you get to evaluate that holistically because the recruiter called them back at all, when they otherwise would have been bounced before your discretion came into play
I don't think Argentina is usually considered a "developing" country, even with the incredibly wide range of meaning the phrase is five these days.
Kind of like the puzzles in a newspaper.
As far as I've read, they undertest a lot in Japan.

It also probably helps that like other asian countries they wear masks all the time, everywhere and without complaint.

Japan also currently doesn't let anyone in to the country.
PGSpider cluster engine for PostgreSQL developed by Toshiba
This is a good point. I talked about capabilities at the language level, but they're just as important if not more-so at the operating system level.

If you have capabilities in the programming language, then you can make guarantees about what resources (like the network) your program's transitive dependencies can use (in process).

If you have capabilities in the OS, then you can make guarantees about what resources a process can use. EDIT: this is how you would use capabilities in the OS to obtain "application jails". But capabilities would be more flexible here, for example by allowing processes to share them.

As monocasa points out in a separate thread, log4j is actually a messy example---messier than I realized when I wrote this post---because the way it (is? might be?) set up is that your application runs in one process, and JNDI in another. Which brings up a lot of design questions around capabilities in the OS and in the language and in how they interact that I don't know much about.

But the primary point of capabilities is to limit how access control can flow from place to place, using standard data-flow mechanisms. In a programming language, this means tying access to whether you have a pointer to an object. In an OS, I think this looks more like OS-level permissions granted to a process, that processes can share with each other.

You don't have some big table somewhere saying who is allowed to do what. Instead, access is granted by a thing, that you can pass around. When you get used to the idea, it just feels very natural and powerful.
Yes !

Thank you
I don't know much about TV broadcasting, so sorry if this is dumb, but what's a segment length? I assume it is either: lengths of a particular shot, or (probably more likely) it is some extra information that is broadcast with the TV signal about how long a chunk of broadcast is?

I like the idea of looking at pixels, just because that's the sort of info that gets sent down the HDMI cable and will always be available.
The "I know it when I see it" rule works right up to the point that you start enforcing it and Goodhart's Law crushes it into dust.

Then all the terrorists you encounter are carrying ornithology equipment because their organization's lawyers told them to and/or actual ornithologists go to prison because they also bought some fireworks for independence day or have a cousin who lives in Iran.
I wonder how Moderna compares --- besides the higher does, the mRNA is a slightly different sequence.
I'm curious whether remote work will have a tangible effect on global poverty and if so, how it could be measured.
The president's salary is sort of a joke though, everyone knows that every single president will have a lengthy tour and series of book deals after their term. They'll be paid advisors to companies and non-profits.

Back to tech though, there are probably 100 100k roles for every 400k role. So if you start out making 100k in tech, you have to be 1 in 100 to move up to a 400k role.
Yes, and you can even have a single process with threads in multiple namespaces. But it still doesn’t solve the problem unless you magik passing all log messages to a dedicated pool of threads just for logging.

The process is simply the wrong layer for this boundary, it’s too coarse and trying to hack your way into telling the OS about the parts of your program. OS security treats processes are black boxes, just like hypervisor security treats vms like black boxes. Trying to force it will be extremely clunky.
Cost is not a consideration until after they have decided that pain management would be valuable, so it can't be relevant in a scenario where it wasn't considered in the first place.
Passat is a far far larger sedan than golf is a hatchback. Any magazine indicating golf has more capacity is doing deceitful apples and oranges - I assume golf with rear seats down (a two seater) vs Passat as full five seater.

Jetta is the sedan version of golf (roughly) and as a five seater it is full 50cm longer than golf. Passat is another 25 cm. It's just more car than golf.

(mind you, I'd always get a golf over Passat but that's precisely because I want a small car and don't need a cargo carrying boat :)
It’s pretty evident at this point it doesn’t prevent symptomatic infection.

Death rate on both is close to 0. My point is if the vaccine doesn’t prevent infection (protecting other people) the vaccine risk vs reward is negligible for this age group. It should be purely up to the person to make their own decision. Not anyone else’s. Treat it like the flu shot.

I was vaccinated when I saw 90% at preventing infections, but now that’s been disproven I’ll call it how I see it. I’m moving on.
As I understand it, the boosters do a much better job "training" (for lack of a better term) B cells.

That being said, I'm going off the preliminary study that shows that vaccine >= infection for older variants whereas vaccine + infection >> vaccine for omicron.

As an aside, I've got three shots of Moderna in me and I caught omicron during the covidtastrophe a few weeks ago. It was extremely mild but I'm now resigned to the idea that vaccines are an assurance against getting actually sick more than a silver bullet.
You might be able to be more specific and only allow network connections to whitelisted addresses or similar.
Saving on payroll tax is a benefit, but it’s also a significant risk for early retirement. Up to 50k/ year for a single person is a real cushion if you start to run out of money. Retire at say 35 and you can probably still get something from SS, but you need to be significantly more cautious.

Similarly saving 15% for retirement is critical, but saving enough to cover inflation is just as important with an early retirement.
I guess the 1% maybe weren't around for it have forgotten the shareware distribution method.
A game inspired by this one but not limited to one play a day showed up on HN recently (to some apparent controversy):

https://news.ycombinator.com/item?id=29534860
What happened to SM100?
The dasterdly Japanese?

Haha. Correction made
> It's more useful to leave the possibility open that it won't go that way as a cudgel.

In other words, it's plausibly unconstitutional.

It's also kind of hilarious that the specific thing you're not allowed to disclose is how cryptosystems work, which is the thing all cryptographers agree doesn't have to be a secret in order to be secure or else your cryptosystem is completely broken and shouldn't be used.
Fun fact, you can't use a credit card to tank gas in the US. When you try, they'll ask for a zipcode, which you don't have since your card is not in the US. Luckily they do take debit cards so you can just use your debit card. But good luck finding that out during your research.

I suspect that if you claim your credit card is a debit card it might work as well, but I haven't tried it yet.
Instagram forbids NSFW content platform-wide.
Linq is definitely my favorite feature of C#
A Jr. Developer job is just fine for me, however the last time FB talked to me they said they were looking for a particular job role (it was lead Developer) and would'nt bump me down... how do you look for a lesser role if you cant be hired for a bigger one?
>two shots of an mRNA still might give decent protection against severe disease; don't know if there is a change with this.

There's not. Severe disease is caused by your body attacking your own lungs because the virus did so much damage between initial infection and your body recognizing the problem. Vaccines, any vaccine, dramatically shortens the time between initial infection and immune response. Shorter duration == less damage to your body in that time.
I still feel as if a guideline with no teeth is better than no guideline at all.
Next time, get the American Express Premium Car Rental Protection add-on as your primary? [1]

[1] https://feeservices.americanexpress.com/premium/car-rental-i...
Here is an example from a sandwich shop: https://www.reuters.com/article/us-jimmyjohns-settlement-idU...
The parent post to yours is actually true, being born in US indeed does wonders to ones access to opportunities, infrastructure, culture, soceity etc.

The USA really makes it easy for people to win. It can be hard to notice it if you've been there all life(or at least most of it), but people like me who have spent our whole lives outside USA(Indian Citizen) and then stayed in the USA for a couple of years(for work) and returned to our home countries can absolutely relate to this.

The difference is like night and day, and it's not even like remotely comparable, being born in the USA even in under privileged conditions gives you lots of edge compared to your peer group.
> given the rate of deaths are 10-20x worse than the worst flu years.

I have a hard time accepting this premise. Mostly because the flu was somehow eradicated at the outset of mass covid testing, many of the covid tests did not distinguish between the flu and covid. Furthermore, I believe that we actually responded to covid in a way that caused excess covid deaths by over counting deaths and actively suppressing unpatentable treatments for covid. I think we hospitalized people that didn't need to be hospitalized, and we told people not to do anything until they needed to be hospitalized. We then started putting too many people on vents, giving them Remdesiver(toxic with highly questionable efficacy), and putting covid patients in nursing homes with the most vulnerable population. Not to mention lockdowns that pushed a huge portion of the world into poverty, nutritional deficiency, and much more susceptible to adverse effects from disease as a result.

But those are just my thoughts- I don't think we have good enough data, nor will we ever- to actually make strong conclusions either way.
If log4j is such a fundamentally bad idea, surely we should expect our tools to stop such ideas from ever being implemented.

In the same way that modern languages are memory-safe (disallowing pointer arithmetic, because it's proven to be a terrible idea), a real modern language would disallow log4j by being capability-safe.
Ask HN: Not getting into tech even if I have a tech-related degree?
I’m about to get my computer engineering degree but I’m having a hard time finishing because I’ve lost my passion and interest. Most of the time, I keep worrying about how difficult staying competitive in this field especially as I grow older. Should I still pursue this career path?
Still seems to fail on a trivial one, so I'm guessing that's a "no".

Edit: Got a quick fix from the author and got a result which is not compiling correctly out of the box, but I'd be happy to finish manually. Definitely saves a lot of typing.
Since neural networks are universal, we can often solve problems we don't know exactly how to solve with neural networks. NeRF is a great example. But once solved, we should try to reverse engineer the solution and optimize.

https://arxiv.org/abs/2112.05131 did such work and found you can get NeRF quality without any neural network at all and as a result 100x faster.
Perhaps! I think some of us are nonetheless born with a lot more wealth than others, and that compounds a heck of a lot.
I'm not sure what their rules are for a software project, but it kind of seems like this is what Kickstarter is far. If you meet your funding goal then you've validated the idea with people already putting $ on the table.
Unsealed lead batteries that go through proper solution maintenance can definitely last decades - I have a forklift that keeps almost 1/2 its original charge and it was made in 1982. but I have flushed and cleaned the cells a few times and keep track of the pH when I top them off.
I conduct interviews for Facebook and we do not discriminate on age. I assume the recruiter just got the impression you really didn’t want to interview with us.
I only do the coding interviews but every piece of interview feedback I write is focused on the same criteria and that definitely does not consider age. We don’t even refer to the gender of an applicant in the feedback, and comments on an applicants age would be a quick way for me to get dropped from the interviewer pool.
I Hate TensorFlow
It's inflammation of the heart muscle.

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/my...

There is a wealth of info about this known condition on the web including symptoms and treatment. If you have concerns, ask your GP, they're there to help you.
My SO experience lately has been the accepted answer is 12 years old and the correct, modern solution is down at the bottom with 1 point and I can't upvote it because they want me to jump through some hoops to get "reputation" before I can vote
It’s out the bag now - you can be identified via relatives DNA.

https://www.latimes.com/california/story/2020-12-08/man-in-t...
Impossible to work with; the start up making it stopped making it. I’ve seen amazing knives made from it, but the knife makers I know that did said “never more”
Java's SecurityManager is very different from capability-safety. It's much more like setuid: SecurityManager allows or disallows network accesses depending on what code is running. (Literally by inspecting the stack)
In Italy, Debit Cards are also the norm and still verified with Avis if they were accepting them and they confirmed they do. And yet, when I tried to pick up a car in Milan with a debit card, I was told that they don't allow debit cards and therefore I could not pick up the card and they would be keeping the money I paid for the whole week.

I will NEVER use Avis again and encourage everyone to do the same. !00% Scam company.

After the whole ordeal I called again and their sales department insists that they accept debit cards.
It largely depends on the affected area... It can kill you instantly if it takes conduction centers, kill you years later if it damages the muscle or it can leave no consequences at all. It can go unnoticed and still leave you with long term damages.
Probably, not just by politicians, but also from everyone who strongly believes is pulling themselves by bootstraps.
Pledge and SELinux are the same level of graininess but pledge’s sauce is that the app has a channel to ask the OS for process restrictions where SELinux has to be applied in advance.
They might still be right; this is only a pre-print, only focused on one specific aspect of COVID and the effect size is small.

But if they are wrong, the most likely explanation is they misunderstood something and were just wrong. Ironically, as is well known but bears repeating, the vocal "follow the science" types tend more to be believers in authority figures than people who care what science says. They aren't especially motivated by evidence.

Actual scientists will usually be circumspect until the evidence is overwhelming.
This is how I know crypto is wonderful. I'm gonna buy more.
Good read, well written, and I like the messages that too much work can destroy creativity and that we just need to be open to much of the randomness in life.
Amazon Reaches Labor Deal, Giving Workers More Power to Organize
Sweden does it. It takes about a 30-35% tax rate.[1]

Nigeria is a poor country which still has a high birth rate. Outside of Africa, almost all countries are past that. Even China and India.

[1] https://borgenproject.org/poverty-in-sweden/
My take is: do whatever it takes to keep the health care systems from being overwhelmed, and no more. Allow people to make their own personal health choices outside of that.

But even that is a hard sell to some people.
I was under the impression we were discussing the authors position (Very high salary + multimillions in the bank), not just >$1M after 12 years.

But in any case...

> I'm sure you would agree it's doable

It's literally not doable.

https://www.investor.gov/financial-tools-calculators/calcula...

Plug in:

- Initial Investment: $0

- Monthly Contribution: $4200 ($50400 annualized)

- Length of Time in Years: 12 years

- Estimated Interest Rate: 8%

- Interest rate variance range: 0

- Compound Frequency: Monthly

The output is $1,010,135.22

This is with a generous rate of return compounding monthly, very high savings rate and not taking income tax into account.

> you can reasonably assume that landing a job at big tech will lead you to a 300k total comp

Joining Big Tech is already an unreasonable assumption for the vast majority of developers: https://twitter.com/GergelyOrosz/status/1400506450124935171.

Someone's propensity to play the career game doesn't magically increase their capability to do so.
Meta aims for ‘deep compatibility’ with blockchain, according to internal post
Correct according to what standard? Is abortion okay or is abortion murder? Is it one up until X weeks and the other after that?

I have my position, but I can’t find any reasonable way to conclude that it’s ironclad “correct”.
While they are also trying to sell you their overpriced insurance I can totally see why they want to check that you have the insurance that covers >$20k of their assets if you crash into another car in an unfamiliar city.

A lot of people don't have comprehensive coverage on their own vehicle, or have a personal vehicle that is of lower value than the one they are renting. I'm not excusing the rude/hostile tactics that some rental places force people to endure (for which they should not get repeat business and be open for legal action) but I can see some reasoning for them to check insurance policy details before handing over the keys.
I like to take a look at the entire picture.

If google, facebook, instagram, youtube required a 7 dollar a month subscription you would cut access to the poor. A netflix subscription in india is a dollar but even at that price it shuts out people and most don't use it.

You are being targeted and identified because people will pay more to show ads to you compared to a poor person. You will get ads poor people won't. The fact that you are willing to allow ads means you end up paying for that poor person's usage. If all rich users decide to adblock the company will be forced to go to a pay model that will shut out the poor.

For the richer users it may be in your best interest to pay. For poor users who cannot afford to pay, don't have a credit card, etc ads are in their best interest.
You could dodge spells in BG2 as they have travel time, you can't dodge spells in a normal turn based system. Also spells have different casting times, some cast instantly others were so slow that people could walk up and hit you before the cast got done. There are many such differences, BG2 is in no way a turn based game. Its real time combat did simulate turns for spell and attack cooldowns etc, but even those weren't properly aligned to turns, a spell cast time could take a fraction of a turn, and travel time for spells were also fractions of turns etc. So wasn't turn based no matter how you view it.