skysight-inc/HackerNews huggingface dataset:
>DNA is not like C source but more like byte-compiled code for a virtual machine called ‘the nucleus’.

I think a comparison to source code would also have merit.

The DNA gets transcribed into mRNA in the nucleus, these are transported into the cytoplasm, where the Ribosomes then translate that information into Polypeptide chains, which are then folded by Chaperones and the Machinery of the Endoplasmic Reticulum. The end result are Proteins, the biochemical "actors" and building blocks. These steps are comparable to compiling source code into opcode.

Also, the DNA itself is just half the story.

Which parts of the DNA can be transcribed, and how often, is encoded in the histone modifications (the histones are "packaging molecules" in the nucleus around which the DNA is partially "wound up") and the Methylation modifications to it. This is known as the epigenetic code, and its just as vital for the biochemical machinery to function as the DNA itself;

eg. It would be very very bad if, say, muscle cells suddenly started behaving like liver cells. Since both have the same DNA (in one organism), it's the epigenetic code that controls which parts of the DNA they "express", and thus what functional identity the cells have.
I just noticed hat GitHub offers a security tab and CVE handling, showing which releases are affected and when it was patched (plus a security policy):

https://github.com/wireapp/wire-desktop/security/advisories/...

Design wise I’d much prefer the vulnerabilities listed upon clicking security, instead of a page that basically has 2 links.
isn't that what the AGE function do?
I've done something similar once, trying to remove backup files left by emacs:

rm -f * ~

instead of

rm -f *~

Is it weird to feel nostalgic about this kind of thing?
I recall hearing that as well but I can't quite remember what the rest of the picture is - something about the other parts of the immune system being able to do the needed work? Or that it was shown that someone with zero antibodies could still be immune?
In Java, I just say "null".
It print the same error even for voices that I have downloaded. Is there anything I can do to make it work?
Paxlovid is expected to work well against Omicron – the problem is production
Pretty much every web provider supports PHP, so it would be as simple as changing the extension from .html to .php
For fast speaking some Northern Ireland Accents can get hard to understand even for native speakers.
This is completely incorrect. As the sibling comment notes, antibody titer against a pseudovirus (synthetic virus containing spike protein; what this figure shows) is a proxy for immunity, and nobody has ever shown that it bears any practical significance at all. Antibody levels go down over time. If they didn't, your blood would be peanut butter.

Antibody levels for absolute neutralization of a synthetic virus in a dish? I have no idea what that means. It's something people look at because it's easy to look at in a dish.

In contrast, a recent paper from JHU and the NIH shows that people who were previously infected have T-Cell responses to spike protein that are almost completely unaffected by mutations in Omicron:

https://www.biorxiv.org/content/10.1101/2021.12.06.471446v1

In short, there's excellent data showing that long-term immunity to Omicron is robust after exposure to prior strains.
I suppose its impossible to make a 5 year plan when the game is changing month after month. With countries having 50% vaccination rate, there's always place to brew new variants that might or not be resistant to vaccines and medicine.
Education alone would not help if SWE in many (most?) large companies have no incentives to make software more secure. Even worse - caring about security can make their performance look bad. Companies try to improve security by inflating dedicated security teams which in many cases don't care about an actual product, its code (and infrastructure) but can annoy engineers by arbitrary rules/checklists/policies e. t. c. which IMHO rarely improve product security.

How to create this incentive is an open question but more laws and regulation doesn't look like a good answer to me.
The norm? I'm highly skeptical. Why isn't there more focus on preventative measures? Even with the Measles vaccine we know to give vitamin A for treating measles.
These are valid concerns.

It appears that COVID is a blood disease, as opposed to a pulmonary disease.

I know a 19-year-old girl that had a stroke, as a result of COVID.

I was talking to an acquaintance that is a mortician, a few months ago, and he said they could always tell the people that died of COVID, because their blood had a different consistency.
If you think that the words "white supremacy" in that commit message allude to Strunk and White (maybe in a tongue-in-cheek way), then how does "people of color" fit into this?
Well-preserved dinosaur embryo found in fossilized egg in China
Would m1 max work?
That is indeed one word. However it's a compound of two words, one of which is itself a contraction of two other words.
This one is beautifully sarcastic.
They want regulatory capture to stabilize their investments. If they would want Facebook to behave, they have all the means because they are investors...

For public safety... who is expected to believe this aside from arstechnica?
This is a plausible scenario, definitely worth considering especially given Microsoft's track record.
At least in Germany the most common reason not to use Zoom has been privacy and data protection, not so much security. Haven't heard the security reason yet.
Oh, I've heard it - a lot :) But it's probably not used as much anymore, it's been a long time since I last heard it.
With VSCode, they had to prove themselves in order to bring people in. No one would have used it if it were as horrible as Teams.

With Teams, on the other hand, they've got nothing to "prove", they just need to show up. Enterprises eat it up automatically because they already use Office, so "it's free".

I also don't think they have any hope of attracting people from outside the MS ecosystem, so they don't even try. I'm actually quite surprised they've put out a Linux version which isn't any worse than the Windows one.
A classic counterexample is

"Scientists took 166 bone samples from 151 mummies, dating from approximately 1400 B.C. to A.D. 400, extracting DNA from 90 individuals and mapping the full genome in three cases." as reported (for instance) on https://edition.cnn.com/2017/06/22/health/ancient-egypt-mumm...
> I'm about to show you a complete finite representation of an irrational transcendental number: π.

You just provided a great argument that π, and many other real numbers, should be part of the 'alternative number system', because they can constructed, or because they represent a finite amount of information. I agree!

> That is literally the point of the reals, that they are an infinitely dense field.

You are arguing that an alternative number system should be 'infinitely dense', and I agree. But take e.g. the finite/constructive reals [1, 2], they are still 'infinitely dense'.

> They were literally created to model reality.

That's exactly my point. Maybe approaching it from the point of view of 'what are the limitations of this model?' is helpful. Also see the discussion in [2].

This is not an argument whether real numbers are useful, a good model, or interesting (there is not doubt they are all three).

[1] https://en.wikipedia.org/wiki/Constructivism_(philosophy_of_...

[2] https://news.ycombinator.com/item?id=14080024
Check out this paper https://www.medrxiv.org/content/10.1101/2021.12.04.21267114v...

Last page specifically. I think the problem with comparing immunity from infection and vaccination is mostly due to how quickly both fade out with time.
I agree so much! It is baffling to me that so many companies/schools/individuals are actively using it. It is _so_ _bad_. Messages are lost, it reboots spontaneously, it crashes, one cannot turn off emoticons (I think (the UI doesn't help)), etc. It does not even take security seriously. What is good about that software?

And then when I talk about this with colleagues, they seem to be just fine with it...

Anyway, sorry about the rant. But it is just so nice to see that there are other people also dissatisfied with it, and that is not just me.
The real problem with (NVMe) SSD is that they have a limited number of write cycles (a max TB written).

If you don't update your database and indices they are great. But that's something really tempting to do when you do some machine learning, (specially if you know that people with deeper pockets will do so).

Typically you will have a neural network, you run it on your dataset, it produces a new dataset of embeddings, you index them, and you use this index to train a new neural network, and you repeat the loop, hopefully improving results along the way.

NVMe SSD can write at 6GB/s but can only write ~800TB that's about 37 hours of lifetime at max speed.
I found the German Pfand system too complicated. Lidl and Aldi won't accept most of your bottles, and there's no unified symbol for Pfand bottles.

In general, recycling in Germany is really confusing.
Something I find useful is to explicitly separate thoughts into small sentences.

"Bonjour. Parlez-vous anglais?"

"Yes, a little bit."

"Hello. I need a passport photo. The photo is for a USA passport. The USA passport photo is a different size from the European size. The size for the USA passport photo is 2 inches by 2 inches."

I live in a Francophone region and speak like this to the locals all the time. Taking short pauses between sentences also helps.
That's only mac thing. Windows never (maybe in early 90s?) had any consistency and nobody cares. Just look at control panel.
I suspect they know more about it than you. This worked. For the first time in history.
Great Tech Rivalry: China vs. U.S. – Harvard Kennedy School Belfer Center Report [pdf]
I believe that, at one point, it was possible for people to get into password-protected zoom rooms.
A response of "WONTFIX" is still a response, sure, but not the one most would want for a security-related issue.
Ultorg: A General-Purpose User Interface for Relational Databases (2020) [video]
Or, more succinctly, "I see."
Many vaccines require three shots. A key difference is that the timespan between second and third (booster) shot is much longer than that between first and second shot.
They're saying that it had low effect on immediate neutralization of the virus (sterilizing immunity). You're still well-protected against severe disease.

Far too much fear-mongering has happened based on confusion about what different studies are measuring. Measures of "neutralization titer" are pretty much pointless, outside of a lab -- they're a model for immunity with no demonstrated relevance to real-world outcomes.

Studies involving "symptomatic disease" are trying to measure the chance you might get any symptoms at all -- a very low bar. Even the sniffles count here. This is where most of the pro-booster studies have focused, and it's a pretty lame endpoint, unless you continue to harbor the delusion that "zero covid" is a thing that is possible (it is not).

Basically, if you get infected after two doses, you might get cold-like symptoms, unless you're either severely immunocompromised (e.g. on immune suppressants, AIDS, in the middle of a bone marrow transplant, etc.) or so old that your immune system is failing anyway.
Yes, but I'll be the first to admit it's a lot of fun to be able to work like that... from time to time.

Context is important also, a lot of young companies are still trying to figure out their optimal business model, so agility really is more important; adapt or die (kind of).

Lastly, you have to consider why anyone would ever work for a startup; they often pay less, more stress, less security, unpredictable environment, etc... but you get to do ridiculous experiments in production and try to build something cool. It's part of the incentive structure.
I'm vaccinated myself and think that is smart but friends with some people who'd probably consider death before covid vaccines.

According to them there is a good deal of things one can do to reduce risk of severe infections.

Personally I have started taking extra vitamin D in addition to the one I get from cod liver oil. It sounds smart and it seems science supports it and I don't have to buy into the rest of what I think is kind of crazy.

(to be perfectly clear, I'm vaccinated and I recommend it. Vaccines have small and uncertain side effects. Viruses have large and much more certain effects.)
> and had the resources to build as much as the Romans did would less of their buildings have survived or would they have been of worse quality everything else staying equal?

Thanks for the question.

It would be a very long discussion to have in details, starting from the fact that even in ancient Rome there was some culture of preservation, like the restoration of 82 temples in the programs of Augustus (see “Preservation Practices in Ancient and Medieval Rome”), but it wasn't until 15th century that a real program of preservation and protection of old buildings was created by the papacy.

Rome was, more than any other city of its times, subject to invasions and destruction of its ancient monuments, used as construction material for new buildings and churches.
The need for churches was actually more a detriment than a a blessing.

The capital was moved to Constantinople more than a century before the sack of Rome and the fall of the western Roman empire, its monuments, its marbles, its travertine, its bricks, have been for more than a millennium up for grabs, by many conquerors.

In Greek cities, for example, there were no monuments to steal from, because they had been ruins for centuries already, Rome almost disappeared during the middle ages and, but the need for materials and the sacks never stopped, making new buildings, every time larger and richer, was the new normal, it was probably the most prolific period in history.

The fact that so many Roman buildings survived despite most of the original material was removed and used somewhere else, it's kinda miraculous.

Take for example two great historical figures: Alexander the great and Genghis Khan, their empires were immense, some of the largest in history, but buildings of their era are virtually non existent.

It wasn't their strongest trait, they were not builders.

Compare them to the Mesopotamians or the Egyptians and it becomes easier to see the difference.

Greeks influenced a lot both Etruscan and Romans, but it was more of a style.

Advanced construction techniques in Etruscan region were brought directly by Greek natives, but only the most privileged classes built proper houses, the rest of the population was living in villages made by tents or wooden shelters.

That's why very few of them survived.
There are a number of commands named "trash". But I don't want to keep in mind to execute "trash-empty" occasionally, especially when rm'ing the same large file several times (say, ones made by "dd if=/dev/zero ..."). So either a cron job for emptying the trash, or I think more elegantly, have "trash" just empty the trash before trashing the next file (i.e. there is only ever one thing in the trash).
no commute: get up later, have more time, no need to stay up longer to get something private done, and if I stay up longer not hat bad because I can sleep longer.

All splendid
Optimal Virulence
High levels of preservation of just about anything 60--80 million years old is rare and unexpected.

Tyrannosaurus Rex is amongst the most iconic of all dinosaurs. All knowledge we have of them comes from 18 known specimens. Of those, only 8 are 50% or more complete. "Sue", one of the best preserved examples, discovered in 1990, is 85% complete. The "dueling dinosaur" specimen (found locked in battle with a Tricerotops) is 98% complete, the most perfect yet found, discovered in 2006.

These finds are rare, they're often very partial, they're often distorted by geological processes. For example, Sue's skill is deformed due to movement of the substrates it was entombed in, a fabricated replica correcting this distortion is used on the mounted display at the Chicago Field Museum, the original is displayed separately.

A "perfectly preserved" specimen is one that is intact, in its original arrangement, not damaged, and not distorted or scattered over the landscape (or more accurately, across the strata in which it was buried).

Some respect for the time, processes, and good fortune involved here would be appropriate.

https://en.m.wikipedia.org/wiki/Specimens_of_Tyrannosaurus
I disagree. I got a home test positive last week and plenty of my friends did as well. I am in the UK though, our home tests might be different.
Das interessiert keine Sau.

No (female) pig cares about it / No sow cares about it
No one claims there is no degradation nor any decay.

Only that the fossilization is faster than total decay.

And no one agrees with you that a news article is supposed to include the full paleontological details.

> would you believe that too?

But, they aren't, so your question seems pointless.

> Is this really a plausible argument?

Like I said, you clearly don't understand fossilization.

It's a slow process. Precisely zero of the descriptions at https://en.wikipedia.org/wiki/Permineralization match your characterization.

> even though they are impossible to believe

You have yet to used your skepticism to analyze your own arguments. If your understanding is wrong, then your conclusion about what is possible to belief is likely also wrong.

For example, you still haven't explained why you think any fossil rock should be uniform, with no way to distinguish between fossilized bone and its surrounding matrix.

> you would think we a fool or a liar

No. Again, use your skepticism on yourself.

My first thought is that you sealed the egg, heated it up to kill any bacteria (but below 60C, which is when the egg white starts to congeal) and then ... let it sit for 20 years. No bacteria can come in. No fluid can go out. Why couldn't there be liquid after 20 years?

My second thought is you had it in a jar of lime water, which is an old way to preserve eggs, yes, even for years. https://theoldwalshfarm.com/water-glassing-eggs/ claims still edible after 2 years, so I can believe still with liquid after 20.

So we know that eggs can last for years, with liquid inside.

Why are you so trusting in the correctness of your beliefs?

And the claim isn't even that the egg was hermetically sealed in order to be fossilized. Over time the content of the egg is replaced with groundwater, while in an environment that doesn't easily support organic decay.

Which we know exists, as we've found 2,000 year old bodies in bogs, and the rock formation the fossil was in indicates a fluvial environment.
> Somehow we still have medicine (they do a lot of testing before they release anything!) and doctors (they have insurance!).

The fact that doctors are relatively frequently sued in the US is one of the reasons why US has very expensive healthcare. If you are rich that's fine, but almost everybody else would prefer more available (cheaper) healthcare with doctors who don't need to spend money on liability insurance.
I have a fairly generic, south east English accent, much like you'd hear on Radio 4, and weirdly the country where I have the most trouble with people not understanding what I'm saying is the United States.
http://www.ultorg.com/

https://twitter.com/ultorg
I've never heard "als druff" but I'd like to add "das ist mir Latte" as a variant as well as "das ist Jacke wie Hose" ("jacket like trousers", which is more like "potayto, potuhto") and as others have pointed out "das geht mir am Arsch vorbei".

But none of them is an exact match as there's no perfect overlap for all situations to which "zero fucks given" can be applied. Which isn't too surprising as most idioms and even most words don't map 1-to-1 between languages even when they share a common root.
Seriem/Kašlem na to zvysoka — i shit/cough on it from up above
> (nothing specific about English here, most of us speak like that in our native languages)

I think it actually is something specific about English. English is stress-timed, which means that sounds are given variable amounts of time, and what gets a regular timing and rythm is stress phrases. Many other languages are syllable timed, which means that the syllables each get roughly the same amount of time. This is probably what creates the impression of the english mumbling, speaking fast, or "eating" sounds.

Edit: agree on the rest, it's probably not the vocabulary or the grammar
South Africa had it first.

https://www.worldometers.info/coronavirus/country/south-afri...

And, as expected, it appears to be far less harmful than Delta, which was less harmful than the original novel cov2. This is how a virus evolves, it gets weaker, which allows it to spread faster. Dead people don't spread viruses. It looks from the data that we are finally at the end of this pandemic.
Probably to auto-update? I can't think of any other even remotely valid reason.
> still getting irritated by Firefox taking forever to render a 10M email source code in plain text when it could do something smart and render/view only the viewport that's showing.

How do you know what's supposed to be in the viewport, especially if the font isn't monospaced? You have to 'render' the entire thing at least once - at least to the point of measuring the dimensions of text (not a cheap thing) and figuring out where you have to force linebreaks. And whenever the user resizes their window horizontally or does various other things, you have to do it again.

Your typical browser is already pretty good at this - not to the point some dedicated text viewers/editors are, but pretty good.
Why YOU should write a Blog – A Mini Rant
Only to macOS/iOS users.

Edit: Who can afford paying a premium for privacy (if one agrees with the parent assumption, that is).
Or, because it's nearly unusable due to 30 years of supporting legacy?
Linux Has Grown into a Viable PC Gaming Platform and the Steam Stats Prove It
It's a safe bet that Google is using transformers at scale for search and translations - the full extent isn't public but they release a fair amount of research papers, e.g. the current article, or https://ai.googleblog.com/2020/06/recent-advances-in-google-...

Github Copilot is definitely GPT-3-based and is seeing real-world use https://copilot.github.com

Transformers are state of the art for many tasks so they are likely to be used for "intelligent" processing of text or speech data, but due to practical limitations you are probably interacting with them mostly through web services.
to clarify, it was a joke
Enough to close everything in the dead of winter and during celebration season
I had to look up gerund, which very much proves you correct.
This is pure misinformation. The CDC is removing one specific test, which the CDC provided to state-run labs when no alternative was available, because now plenty others are available on the open market.
Right, I speak a sort of broken English to Asian speakers. Just dumb it down a bit. I always smile when a friend visits and tries to speak to non-native speakers the same way he talks to me and I see they can't understand him as he's rambling away. I'll then adjust based on how the conversation flows.
Mac just ruthlessly breaks compatibility. Sometimes, that's a good thing.
Instead of Stdlib.Queue you can use Eio.Stream, which is thread-safe (and will take care of waking sleeping threads when data becomes available).

The README shows an example of a pool of workers pulling jobs from an Eio.Stream:

https://github.com/ocaml-multicore/eio#example-a-worker-pool

We're still exploring what APIs to provide for this kind of thing, and in particular how to unify domainslib and eio.