skysight-inc/HackerNews huggingface dataset:
You may want to add an email address to your HN profile. Or have some method of contact listed.

I do something very similar in a research lab, and while it’s possible to make decent headway in this without much training, there are dragons all over the place.

For example, you didn’t mention which reference genome was used for the alignment/variant calling. Unless you use the right version for annotation, you’ll just get junk annotations that won’t make sense. I’ve only seen a couple of comments mention this.

If you don’t have the background, you might also need a crash course in human genetics, inheritance, molecular biology and variant functional prediction. You don’t need to become an expert, but you will need a working knowledge so that you know which variants to ignore. There really should be a small handful that would potentially make sense as a causal variant.

If the condition is sufficiently rare, you may not find clinical annotations, so be prepared to look a little deeper.

Best of luck.
Everyone is at work.

In germany if you take a walk during the daytime your looked upon as a "slacker".

Friends require to be condemned to boredom together.

Relationship require something called perspectives in life.
Why produce spawn for a dieing world?

This is what you wanted in the 70s when you demonstrated for a "humanity" capable to hold back from environmental destruction.

Its a species of monks, waiting in their cells to dwindle to zero.
that has been a common problem with tech utopians, and not one I'm personally interested in. Tech doesn't change society for the better automatically, but it can create incentives in the right direction. Are we really saying a world prior to the printing press was better? What about before freely available information online a la wikipedia? No way.
I came here to post my thoughts, but I agree with everything mentioned.

Here in baltimore it's about fear of being a victim of violence.
Good luck sending emails with IPv6.
CuddlyNest
CuddlyNest is the fastest-growing accommodation booking platform built by travellers. Offering millions of properties of all types across 200+ countries, it focuses on a traveler-first approach. The platform offers the lowest aggregate commission fee on the global OTA (online travel agency) market, setting out to revolutionise the booking system by cutting unnecessary travel fees with its innovative booking fee-sharing model.
Yes. IPv4 is actually a cost for Hetzner. You can see it already on some servers as an additional price tag.
We are victims of our own comfort. It's easier to stay home in our filter bubbles unchallenged. People don't know how to socialize these days, it's easier to flick idly through facebook. Awkward conversations with strangers don't happen anymore, because the second a familiar conversation with the bartender ends, everyone reaches into their pockets and retreats back into their digital security blankets. Try having a conversation with someone, and count how many seconds it takes for them to pull out their phone, and instead of correcting them on it, just talk babble and watch as they scroll. There is no intent in the scroll, it is just idle time and a slow drip of stimulus to the frontal lobes.

It also doesn't help that every news broadcast and TV show is somehow furthering agendas that divide us, or polarize topics into idealogical tribal warfare.
> [Rain] made our diminutive solar-power system effectively useless and leaves us paying for diesel to run a noisy, exhaust-spewing generator for daily power.

... you're not very far "off grid" then, are you? As to the "composting toilet"; how about an outhouse? Or bury a 55gal barrel and make your own septic system?

Buying firewood because you don't have enough time? The whole point is to do things yourself instead of buying from others, isn't it? It was a big point for the hippies founding communes in the 70s.

I suspect this person meant "off grid" as some amorphous notion that would confer Moral Cachet, and never intended or considered the actual "live with less" part of such a lifestyle. "Let's go camping the Northlands in Winter" is likely to be literally, deadly stupid. At least try it somewhere with better weather.
> you could be bankrupted by it

It's tough to be an expert, to be well informed on how US medical care gets paid for. I'm no expert, but I know a little more than nothing:

So, for "bankrupted", yes, sort of ....

But the US has Hill-Burton hospitals, likely named after two guys in Congress who got the bill passed. With the Hill-Burton act, if are starting a hospital, then can get funding via the act. BUT: Have to accept all patients independent of ability to pay. Soooo, a large fraction of city hospitals are Hill-Burton. Then there are the medical school teaching-research hospitals -- again commonly or always, patients are accepted independent of ability to pay.

If someone really is broke, then they can qualify for Medicaid -- "never receive a bill for medical care."

For people old enough to be retired, there is Medicare. Part A covers a major fraction of hospital charges and is free. Part B covers physician charges, and is not free, maybe a few $hundred a month. There is another part for drugs.

For poor people, there is the HRSA (Federal Health Resources Services Administration) or some such -- clinics with sliding scale charges based on ability of patients to pay.

It goes on this way. It's a patchwork system. Not all the important details are really clear. E.g., there is a lot of over billing, that is, charging too much, and in this case the insurance company has a talk with the physician/hospital and negotiates lower charges. For drugs, the prices can vary enormously based on whatever.

There has been at least one effort to get the medical providers to publish a price list, i.e., to clear up the lack of cost information.

I don't know all the details, but my understanding is that it is very rare for medical care charges actually to bankrupt someone.

E.g., one approach is for a patient who owes big bucks to pay, say, $10 a month for 6 years -- then by laws of debts, the rest owed is forgiven, that is, not owed.

One way and another, in summary, from 50,000 feet up, generally, the US tries really hard not to have all of medical care run by the Federal government, or any level of government. E.g., there could be a system single payer where the there is only one entity that pays for anything about medical care; of course, that entity likely is run by the Federal government and gets a lot of tax money. Single payer has been proposed 220,872,879 times and rejected by that many times.

Some of the scare is that single payer would result in some or all of (a) taxes way too high, (b) too much just wasteful, silly, and unneeded medical care, (c) low quality of care and, thus, too many people hurt or dead, (d) too little capacity where too many patients die from waiting too long for care, etc. I don't know what if anything is right/wrong with (a) -- (d), but these are concerns commonly voiced.

Maybe the US could borrow from, at least learn from, Switzerland, England, ....

But actually bankrupt from just losing a job? I suspect that is actually not very common.

Oh, by the way, if fired, then commonly get to continue medical insurance coverage for some length of time.
I feel like the reason Elon Musk cares about brain implants is not because it has potential to help people with spinal cord injuries, its because it's such a sexy sci-fi technology. Im not saying it's a bad thing that they are researching this technology, but I hope it's understood that brain implant chips are probably never going to be a good idea for normal people. The risk of getting something inserted into your brain is enormous.
You couldn't purchase digital art before NFTs in a permissionless global market. period.
This is a great read, I'll definitely follow this and come up with a plan
The article has maybe three paragraphs of actual information.
> The report is based on an online survey of approximately 950 Americans in October 2020. Because of certain data limitations, the data should be considered preliminary. More information is available in the report’s methodology section.

- what's the baseline? How many people feel lonely on a good day? How has it changed since then?

- "online survey" is there a selection bias skewed towards those that are more inclined to identify as lonely?

- how does this correlate to how many young adults have a SO / are married?
Supercharging Optical-Disk Capacity
If there’s a lull in conversation they pull out their phones.

I despise how this behavior has been completely normalized. Especially in the dating sphere. People putting their phones on the table to make sure they never miss notifications is just so fucking disrespectful to the people you're actually with.
I assume this is common knowledge, but I personally find Hetzner to be exceptionally good.

It's always been good to me when I was using their European data centers, but that was always a bit of a bummer because of latency. Now that they have a DC in the US, I just can't think of a single good reason to use other cloud providers for smaller deployments. They're pretty much the best bang for your buck you can get anywhere.
The cheapest Hetzner cloud server is also around 2-3 eur/month.
To be clear, I haven't bought it expecting a gain in performance and I didn't get any. The purchase was motivated by my desire to have a more pleasant feel while typing, and that I most certainly got.
Patching is relatively easy to solve with immutable infrastructure. Build a new fully patched AMI every night and when you release you pick (version of code, version of AMI) to deploy.
It is frightening that the world's largest arsenal is under the control of such an irrational institution.

Here's a favorite HN comment of mine, about the US Navy - "zero capability to accurately assess risk or fix problems beyond punishing people when things inevitably go wrong".

https://news.ycombinator.com/item?id=15120369
Or, perhaps a more charitable reading may be "if you’re not staring at a screen perhaps you’ll meet people while out and form social bonds"?

If you’re very online and you’re lonely being very online then proposing that you change what you’re doing to perhaps get different results is not the same thing as "have you tried not being sad????"
As apt as those suggestions may be for this crowd, they are neither practical or even polite for a huge proportion of the country.
> ... Compiling simple programs into silicon should be like using llvm or gcc: fast, automated, and accessible.

Some benchmarks would have been helpful. What kind of performance gain are there to make?
- USD is not a commodity or an asset.

And yet the point stands. The value of the USD depends on a large number of people collectively agreeing that x dollars are worth y loafs of bread.

- "security by hashpower" assumes that PoW is the only way to go, when the important feature of blockchain is that it works to BFT consensus.

Yes, security by hashpower assumes that PoW is the only way to go because so far that is the only thing proven to be resistant to a wide range of attacks that made previous attempts to solve the Byzantine General's problem fail. Do you really believe that Satoshi Nakamoto didn't consider PoS as an option?

> A security system that is expensive to maintain and consumes so much resources in a non-renewable fashion (and I am not talking about energy production, I am talking about energy itself) is a bad system, period.

Bitcoin mining is one of the most concentrated sources of renewable energy demand in the world today. The game theory economics unlocked by the availability of a high demand for low-cost electricity without regard to it's location or proximity to a population center is a game changer. It will reshape nations and society over time.

> We should not be looking at how much hashpower it is using and thinking "that's a good thing", we should be thinking "how can we have a consensus system that is more efficient and less wasteful".

I agree. Until we find those solutions we have Bitcoin and PoW.
> legitimate use

It is "legitimate" to use a cryptocurrency to buy pot. It may not be legal, depending on your jurisdiction; but "illegitimate" is a fuzzy word, expressing some kind of subjective disapproval.

I personally think it's illegitimate to criminalise drug use. But that's just a subjective, personal opinion.
1) The rules about the 21Million which is the only thing that matters here can't be changed.

2) Again there is a reason why Bitcoin Cash is a fraction of BTCs value it's not the same.

3) Everything can be manipulated. You go and see how Soros did that in the 90es. But again that's not the measurement here. It can't be changed.

It's been a house waiting to collapse for 12 years now. Maybe you should ask yourself what it would take for you to admit to yourself that you were wrong. How long does this have to be a thing?
My wife and i had kids at your age and 15 years on we're all doing very well. We know older parents, also doing well. We were told there were some risks increased for an older mother, but with hindsight these were small percentage chance of something to a slightly larger but still very small percentage. True, no one wants to be the rare bad case. If you're planning pregnancy, i think i recall it's good if the mother has Folic Acid, but I'm no scientist. https://www.cdc.gov/ncbddd/folicacid/about.html Good luck, I hope it works out.
The loneliness crisis is tough because it can make someone feel like there's something wrong with just them. Walking the streets on a weekend night, all you see is groups of friends at sold out restaurants, people on dates, events, etc.
Open Source Cloud Asset Inventory with TimescaleDB and Grafana
> That requires an investment of time and of your emotions - something many people seem unable or unwilling to do.

Unwilling or stolen by tech companies who engineer addiction?
That was an excellent read.
All the information in the integers is in the primes
I know you are being funny. However, it does make me think hmmm... Is there any advantage/disadvantage to not handing out something like a /120? Or is there something else at play like in the way auto discovery is working? I am not familiar enough with it to say.
I'm sympathetic to the later part, but first part not what they want.

They want the dynamism of being able to change jobs and careers, they all want the opportunity for career progression which for the most part isn't there (it's always been competitive).

That means more risk and all the things that come along with it.

I think even 'remote work' will have a serious of consequences we're not ready to accept, which is that it will make workers even more fungible.

If someone literally can't show up for work ... then they're generally going to be seen as more easily replaced or changed around.

We need to fixing housing costs badly though.
That's a really clever idea! Although I would have much preferred they didn't use it at all... :-/
Show HN: WealthPIC – a tool to automatically generate stock/ETF portfolios
Hey folks,

Just wanted to quickly introduce a small side project I've been working on for the last while.
I’ve been exploring the idea of a passive income for some time now, specifically in the context of dividend-paying stocks/ETFs. Very quickly, I realized that it’s pretty challenging to be able to come up with a portfolio that would generate you a required X dollars per on average.

The task overall seemed like an optimization/search problem so I decided to try using my favorite genetic algorithms to tackle it.

So, after a bunch of months of spare-time hacking the first version of the project has been released - WealthPIC, a free Passive Income Calculator - https://wealthpic.info!

The basic idea is simple - given an objective ("I want to receive X dollars per month"), the app will generate a totally random portfolio that satisfies it. Then one can start playing with it by adding additional constraints, filters, pinning and removing entries, and so on until, hopefully, the dream portfolio is found.

The app is in a very early stage and most definitely contains bugs but I think it might already be useful enough, plus I'm hoping to continue working on it and add new features.

Would gladly accept any constructive comments and feedback.
If an IPv6 spam filter is working on a per-address basis, it's never going to work. The smallest allocation you can get from a RIR is a /48. Even residential ISPs give at least a /64. You could use a different address for every email and never run out.
I agree, don't pollute.

False equivalence.

We can talk about carbon taxes and renewable energy if you'd like, but if we're going to go down the path of "any energy use is sin unless I approve of it", then I ask again; do you not bore of telling others what to do?
I've used Django for a long, long time (since 0.96). Django is great for backend stuff, but nowadays for full stack applications (if you're not doing an SPA) I find Laravel and Rails a lot better. In particular Laravel's templates (blade) and asset handling is awesome.
Yes, my question is if there's any indication why Czech Republic is special case as you can clearly see its borders.
Do the positions your staff work promote having enough time and emotion left after a days work to go out and pursue those things? Does your staff have enough financial stability to make impulsive but fun decisions? How do you quantify your answers to these questions? By asking your staff directly? During staff meetings or Zoom calls? Or by actually watching the decisions they make and the problems they face?

Many jobs out there use up workers like a resource. And the well is running dry.
Huawei's Latest Laptop Pairs DDR5 RAM with New 5nm SoC
Headed for a 6th mass extinction? MIT geophysicist warns oceans are on the brink
This. Just hit some random shit on Meetup.com that looks interesting which bridges the gap to the real world.

Online social is a complete shit show. You’re spending time with peoples outward persona not real people.
I could be wrong, but do you think it's possible that your staff actually fall in the 39% bucket? That is, they either don't feel loneliness or feel too little of it to do anything about it.

Otherwise I agree with you on dealing with loneliness.
One of the things I blame is the decline of youth culture. When I was in high school and college (late 90s - early 2000s) we had all these youth "scenes" like goths, ravers, gen-X style hippies, garage band scenes, hip hop, underground punk, and so on.

The standard formula was music plus style plus some kind of group bonding activity like dancing, playing music, going outside, etc. Drugs were pretty often involved too, but not always and even in drug-heavy scenes like raves there was a sizable "straight edge" faction.

This was basically how all the young people who were not "jocks" or into other official activities (of which there is a limited selection) would meet one another and socialize.

Maybe I just don't know, but this stuff really seems dead. I've spent some time digging out of curiosity and I've never found a hint of anything similar today. It seems like it all moved online into social media and now instead of dancing all night in warehouses or going camping to hear a band people just stare at phones and have their brains sucked out by "engagement" (addiction) maximizing algorithms.

So social media seems like one thing that killed it, but I also think police crackdowns motivated by standard issue drug war freakouts were a factor too. (Irony: the replacement, algorithmically curated social media, is much more addictive than a lot of the drugs I remember people doing back then.)

So now there's the people who are into the mainstream standard stuff and... what? Social media? 4chan?

I shudder to think of who I would be without rave culture in late high school and college. I'd probably be dead of suicide or one of these hate-ridden incels or pajama Nazi CHUD types. I'd put my money on suicide.

Edit: my philosophy with my kids is that screen time is okay as long as their lives are full of a lot of other things. I don't think screens are the problem per se. I was also into hacker stuff when I was a kid and spent a lot of time in front of screens. The problem is the absence of enriching social activities, not the presence of a screen. I do selectively ban certain things though, like YouTube, that are particularly toxic.
What a nasty shell. You can't even error check like a man.
Fascinating talk. The overall approach here strikes me as being extremely influenced by QNX's design. Send/Receive/Reply as a messaging primitive is too often overlooked, and provides incredibly powerful that (as Cliffe mentions) renders an enormous amount of scheduling complexity as moot.

Anyone who's done the UWaterloo trains course will recognize these patterns immediately, and (IIRC) interrupt dispatching is was done in a similar manner there as well.

Finally, the supervision patterns here strike me as being very similar to those within the BEAM, and remind me of the infamous quote from Robert Virding (http://erlang.org/pipermail/erlang-questions/2008-January/03...). Obviously a necessary reimplementation here, but humorous nonetheless.

Great project, great talk.
Connectomes require not-so-accessible equipment such as fMRI or MRI machines. Nevertheless, the best way to visualize it in my opinion is via the Brainstorm package (created by University of Southern California) in MATLAB.

Honestly, the holy grail is really here and it is open sourced. It only requires EEG: https://direct.mit.edu/neco/article-abstract/33/4/967/97477/...

You can use FreeEEG32 with the prior link, which is coming out very soon (I spend a lot of time with the discord chat people who created this system): https://www.crowdsupply.com/neuroidss/freeeeg32

To use dry active electrodes (in lieu of wet electrodes—aka gel in your hair) with FreeEEG32, you can make your own EEG cap with dry electrodes—using this page to figure it out: https://hackaday.io/project/13285-openld-lucid-dreaming-rese...
> It’s not practical for most, but I think you can, by moving to the European Region.

Or I can’t just not use WhatsApp. It’s not like it does anything more than any of the other messaging services.
I currently struggle to buy anything that would have a positive effect on my happiness. I got a motorcycle two years ago, and while I do pretty few miles, it provided quite some happiness (going on Saturday rides with a friend, general added feeling of "freedom" because of having a way to escape the city and also do short trips I usually would fret about which public transport to take or if it makes sense to use carsharing). Another thing that comes to mind is my Vacuum cleaner - I spent money on a cordless Dyson and I can clean my small flat in 15 minutes now (robot doesn't make sense due to the size).

I have the budget to buy some live improving stuff, but I don't see anything.
> If someone literally can't show up for work ... then they're generally going to be seen as more fungible.

It depends of the company culture.
The average daily low temperature from December - February is below 5°. The average daily low in January is below zero. It's a cold, barren place.
Ah yes, nothing like being forced to live with strangers and parents to solve loneliness. Seriously?

If you care to look, there is actually a lot of research pointing that the pandemic affected the poor's ability to voluntarily socialize compared to the wealthy. If you think about it, it's incredibly obvious.

And yet these authors didn't mention the idea once. That's unconscionable, if unsurprising.
At least for my team we went with FastAPI because we have other tools for everything else, and FastAPI is incredibly simple for new members to pick up. We tend to say that we made a “FastAPI application” but in reality FastAPI is only powering the REST interface for interacting with the platform.

We use SQLAlchemy for database interaction, a lot of direct usage of Pydantic, Celery with RabbitMQ/Redis for task processing. FastAPI provides a really lightweight interface to gluing pieces like this together.