skysight-inc/HackerNews huggingface dataset:
What a meaningless way to phrase it. "Only $20"? Ha! How about this phrasing...

Pfizer Expects $33.5 Billion In Vaccine Revenue In 2021
https://www.forbes.com/sites/aayushipratap/2021/07/28/pfizer...

https://www.cnn.com/2021/11/02/business/pfizer-earnings/inde...
The vaccine business alone was responsible for more than 60% of the company's sales, as vaccine revenue rose to $14.6 billion from only $1.7 billion a year earlier. The company said its Covid vaccine sales accounted for $13 billion of that revenue. Revenue outside of its Covid vaccine business was up a far more modest 7%.

In secret vaccine contracts with governments, Pfizer took hard line in push for profit, report says
https://www.washingtonpost.com/world/2021/10/19/secret-vacci...

Pfizer, BioNTech, and Moderna making $1,000 profit every second while world’s poorest countries remain largely unvaccinated
https://www.oxfamamerica.org/press/press-releases/pfizer-bio...
> I'm actually doing a VRP using genetic algorithms for a final project right now

Don't forget to compare it with simulated annealing to find out if Skiena was right about GA in The Algorithm Design Manual when he said that he "[has] never seen any computational results reported using genetic algorithms that have favorably impressed [him]".
This wasn't a particularly interesting or novel prediction in 2009. TiVo had existed for years.

That's all people really do differently with their TV/computers today: they watch on-demand.

Even in 2009, some people had set up Linux machines as entertainment boxes to create early Roku-like devices that could stream pirated or ripped content.
You seem to think a persons worldview is under their control

The important discovery people make is lucid awareness a chemical did this to them

Unlike booze where you black out

Whether the brain gives rise to us it’s a medium that exists and it can’t be discounted it has a lot to do with our awareness

That we can be just chemistry is the shift in metaphysical belief I came away with

The oceanic connectedness being we’re all just a few micrograms of this or that from being the same. That perception of uniqueness is not uniqueness
> Aren't antibody titers just one measure of immunity?

Yes. But Omicron just came out 3 weeks ago.

--------

We start with the quickest measures of immunity. As better data comes in, we change our opinion. The gold-standard is a large-scale, multi-month A/B test. There simply hasn't been enough time for that to be created.

If these smaller tests prove adequate, we probably will skip the large-scale test... much like Alpha and Delta, it seems like these variants don't last very long in practice. We just barely finished studying Delta's effects across a variety of treatments, and all of that data is about to become obsolete with a new variant.
I'm riding on this comment here (sorry) just to say that whoever flagged the parent comment should be ashamed. I have no idea what the commentator said and the idea that anyone can just flag a comment and have it hidden is so wrong imo I don't even understand how it's a feature on HN.

Very disappointed.
> a poor kid in USA still has everything they need to get to top 10%

As a poor kid who did this, this is an incredibly ignorant and out-of-touch statement. This is like the socioeconomic equivalent of that Verge PC build.
So how about all those accounts spreading misinformation about the Rittenhouse trial? Where is the trail of suspended accounts artificially amplifying misinformation?

The problem is Twitter is biased against and for some things and doesn’t attempt to stamp out misinformation evenly.
If you ignore the context and the multifaceted consequences of lockdowns etc., then yes, you are correct and we should be obsessed with the transmission rates. However, we don't have the same level of obsessions about other viruses present in humans (say, HSV-1 which unlike SARS-CoV-2 will live inside you until you die), and even other coronaviruses. Why? Because what matters most is how dangerous the virus is.

Fortunately, as of today, Omicron deaths are still at zero, and this fills me with moderate optimism. [0]

[0] https://www.cityam.com/anxiously-optimistic-south-africa-hol...
> sneaking into someones else house and stealing the message you send

I remember watching at least one movie where a character did this.
I think it's because it's not possible to know if that would have happened without the internet and therefore causality hasn't been established.

Like if someone is self-harming, is the problem the tool or the fact that they're self-harming? Such a person might have ended up isolating themselves to watch TV, or read, or other things. I've done all of the above with books and television.

In which case the issue may be information availability offering people a new option: It's a lot easier to ignore the world and read 500 books in a row if I can download them all without leaving my house and there's no check to go 'is this a good idea?' If the issue is information availability, blocking the internet/social media will do nothing. Think streaming Netflix for hours versus flipping through TV on the 90s: You'd stop flipping if nothing interested you, but on Netflix there's ALWAYS something.
Can’t have transparency. This account was posting pictures of Bill Clinton on Lolita Jet and Hollywood celebrities on Epsteins Blackbook. The made men protect other made men.
Yes, at the end you start to question just who the player of games actually was.
...it might be a smell, but they sure are bound to happen eventually; Corrupt user state or unhanded corner cases etc. Better plan for that in advance.
As I understand it, none of the existing major variants is an ancestor of Omicron - their closest common ancestor is quite a way back in the pandemic. Alpha and Delta weren't particularly closely related either.
Damn thanks. I like the German accent.
Aren't savings required to support loans -- business, home, etc? Does that imply saved money actually is doing something?
Roku settles YouTube dispute and locks down apps in ‘multi-year’ deal
Wow, I haven't seen this exact argument play out this exact way 100s of times before! Great addition to the conversation guys. Really insightful.
The Art of Brewing Historical Beers
They also said the vaccine targeted the spike protein, which was said to be very unlikely to mutate since it's such a vital part of the virus and there is little room for variation.
That's why you see the orange color instead of red. To indicate that 1. The survive is not fully functional, or 2. The service is not functional for some regions. And I've seen some companies add comments to each status to explain what's going on.
The talk given by the author https://www.youtube.com/watch?v=0lXvUMfafBY is also quite good.
I'll likely do that. For what it's worth I was not eligible for a booster where I live until very recently.
How to Annoy Your Users and Push Them Away
There is little evidence right now that immunity through a natural infection is better than immunity from a vaccine.

Given the strains circulating now I don’t think your concern is valid. Vaccines are better and less risky than having your naive immune system deal with covid. Maybe that will change with a future strain (though I’d bet against it), but it isn’t the case now.
The comment you're responding to is saying that exactly that definition doesn't work anymore, so your response amounts to "No."
Link? My initial impression is that this would be confounded by people who have severe covid also tending to be old or otherwise sickly, unless they found a way to control for that.
And yet we’re left to guess exactly what Twitter deemed us unworthy of reading.

The opaqueness of the censor is a feature not a bug.
I don't really care about having a vaccine every 6 months but the masks are very restrictive IMO. That can't be forever. There needs to be an actual solution. I know it's not there now but I mean in the long run.
Yes and no. You can order Comirnaty in Germany if you're a doctor's practice, and the deliveries will come from the central distribution facilities in each German state. Those facilities are receiving shipments from the Marburg production facility that BioNTech owns and operates. Similarly, if you were to do the same as a Belgian physician, you would receive shipments that originate in Pfizer's production facility in Belgium. It's exactly the same product though. I don't know if there's a difference in the labeling beyond specifying production site. The production lot labels you get for each dose to be added to patient vaccination records look exactly the same (other than the lot serial numbers of course).
And once again in the special editions, apparently.
A big chunk of US deaths were elderly in nursing homes when officials made uninformed decisions to put infected individuals back into the homes (when we knew a lot less about the virus) and it ripped through. Very sad, but that's where we get a big portion of that 790k.

Given that we've learned a lot, tactics and strategies have evolved, and therapeutics are getting better, death rate should continue to go down.

That's why many places in the US feel somewhat back to normal.
This is not my area but isn't the point of the mRNA vaccines that that virus' DNA is never introduced into your body? You only end up with a narrow transcribed slice of that DNA targeting a specific protein.

I've also never heard of your immune system targetting a genome; how is it generally gaining access to that genome when it is encapsulated?

My understanding of the spike targeting is that COVID is only so infectious because of the specific configuration of that spike protein. Change it too much, and it stops being nearly as infectious (and thus stops being COVID as we know it).
Access to modeling isn't even the issue, given RKI, Charité, ... Asking those resources the right questions and turning their results into policy and communicating it is the problem, which is even more fundamental "that's what a government is for" skills...
The difference between NYC and the rest of NY is pretty dramatic.
It may alter beliefs in general. Just like anything else. Nothing to see here, really.

I started looking into Alan Watts and Terence McKenna because of psychedelics, and I did not even consume psychedelics. They may alter metaphysical beliefs without consumption, too! :)
That's one of the reasons that we need a blockchain-based microblog platform to take off and become popular.
The article's main point was 3 doses of the original vaccine is more effective than 2 for omicron. They expect to have an omicron vaccine available by March if 3 doses of the original vaccine isn't enough.
If an American ever starts bragging to you about how free he is, ask him how he squares that with the fact that he is forced under the threat of incarceration and violence, to subsidize the CIA and the NSA which are the antithesis of freedom.

I do this, frequently, they always shut up, stammer a bit, then walk away.
Ask HN: What is your preferred tool to read source code before lsp?
LSP is of great help, but it is not always working on some project.
> * today: the Amazon shopping experience is so filled with bullshit that it’s actually easier to buy from the producer’s website and pay shipping

I hear this all the time but it’s rarely true for me.

I’ve always searched for alternate stores, promo codes, and other discounts before ordering from Amazon. Many manufacturers have their own web stores, but it’s really rare to find a total price (including shipping) that is actually cheaper than Amazon in my experience.

Many hot products have Minimum Advertised Pricing contracts that mean the sale price is identical across every website anyway, at which point it becomes a game of finding some place with a coupon code that is enough to offset the extra shipping costs of not using Amazon. Most of the time, it just doesn’t work out as cheaper than Amazon.

I think people underestimate just how expensive warehousing, handling orders, and shipping can be. Amazon has optimized logistics to the point that they can charge people a lot for it and still be cheaper than doing it yourself (up to a certain scale which few companies reach)
Something to consider would be local adaptations the emerged over very long periods of time. Most US residents come from a lineage that is (relatively) very recent to those lands.

Also important to note that the US climate is significantly less homogenous, meaning that a somewhat universally high obesity rate is not going to be explained to a large degree by local climate. IIRC, relative obesity rates drop by roughly 40% for individuals with a college degree and in general correlates highly with socioeconomic factors in the US.
Cloudinary is an end-to-end solution for managing images and videos, for developers. The CDN and optimization parts are tightly coupled with the digital asset management: e.g. if you change an image, the system knows to invalidate the relevance cached images, and is CDN-agnostic. So no, CDNs are not competition, but rather good partners to Cloudinary.

Regarding the DAM: CMS and Ecom systems are indeed getting better, but media assets you upload to them become siloed in the CMS. Cloudinary acts as a headless DAM that you can embed in any CMS and use as a single source of truth, relieving a lot of the pains of handling media files and their versions.

FD: I'm a Cloudinary employee
The World Digital Conclave (WDC) has recently launched an invite-only pllatform for Digital Marketing and Technology Professionals to

- learn from each other
- share knowledge
- network
- find or share jobs
- find vendors
- create or join events

and grow together as a community.

If you are a mid or senior level Digital Marketer or Tech Professional, you should definitely check it out. Visit the Play Store link shared above right away.

WDC is an initiative by The Clicks Technologies (TCT), a digital marketing agency working with clients from across the globe.

Check out the android app and drop your suggestions to the makers for sure.
We do have a Delta-specific jab though that has gone through trials. Why not release it for sale? Just to save the government money on all the older jobs they already bought and haven't used?
Google services are deeply invasive, but also tremendously useful. It's a tradeoff.

Firefox ads are just pure spam.
It was talked about, but this was either the first or one of the first academic articles to mention it, if I recall correctly (I may not). Similar to how discussions about how to save things online bubbled up before IA was established or there were a lot of talks about what made a webpage valuable before Google and Page Rank came on to the scene. Lots of collective consciousness going on.
I am not so sure that GBM support was motivated primarily by the Linux desktop community. It's rather a symptom of industry-wide trends.

I work in the automotive industry, where we buy high-end, high-margin SoC SKUs - not a lot of them (compared to phones, primarily), but enough to have some sway. Within the industry, most OEMs are moving toward inhouse platform-shaped development and have a desire to make their code increasingly reusable and hardware-agnostic, as well as lower integration costs for third-party app content. This drives the adoption of open source commodity stack technologies and standards like Wayland, and means hardware vendors now have to demonstrate or offer support for them - with a single code path. It then replaces vendor-proprietary stuff like nVidia's EGLStreams previously used for similar cross-process compositing use cases as Wayland is now. In the past, vendors were asked to solve the problem for the OEM as they saw fit on their hardware.

I've personally requested vendors to provide GBM support on the Orin SoCs by writing it into requirements. I know nVidia previously started incorporating limited GBM support in their GPGPU product line, probably due to similar customer asks in that industry, but I don't know it well.

For the Linux desktop community the takeway is that it has a massive impact beyond just the Linux desktop - by being a leader in the commodification of technologies everyone just ends up adopting, especially as embedded development trends toward a similar complexity level as desktops and phones with similar feature requirements. Accordingly it deserves support from those who have these technologies in their supply chain.
Every new virus evolution = More money for Big Pharma

It's hell of a business.
@dang can we update the link to this one please?

At the moment people are just reacting to the headline and there doesn’t seem to be much substance to the debate due to this.

https://patriotone.substack.com/p/twitter-suspension
I agree, searching for products on Amazon and actually finding what you're looking for is a pain, then you still have to try and figure out if it's a quality product or if it's from a reliable seller.

I shop on NewEgg these days when I can because their power search is much better for the things it is actually implemented well for. For the things it isn't implemented well for you're not really any better off though.

P.S.: If anyone can direct me to a reliable brand for 3-6ft USB 3 A-to-A M-to-M and M-to-F cables that can actually handle SuperSpeed without dropping half the packets, I'd be obliged.
I got vaccinated because I didn't want to die from COVID. I'm okay with getting an annual booster, as I am with getting an annual flu vaccine. The risks of not getting vaccinated were too high for me to accept.

I'm still interested in how resistance to the disease emerges in the unvaccinated population. It will help to inform our response to the next pandemic.
If you dig a bit around the company register you can see that they have been working on getting this working since at least the 80s. So it is probably not something someone can reproduce at home easily
Seems like a net positive: more people can read 1984. If your concern is that someone might publish a modified version of the text, why, public-domain status makes that easy to detect and analyze, because anyone can share the original version, which copyright makes illegal.
Anything that challenges the dominant white, anglo christian narrative must be stamped out post haste! I mean, how the hell else do we justify spending $500bn per year on war and spies?
They shouldn't be in the hospital in the first place.
That's just nuts. Sell me at what price you will but after I buy it, you should not control a single bit on my hardware.

It's like we are going backward in progress.
Dozens of camels barred from Saudi beauty contest over Botox
It's quite an interesting question. There are lots of privately owned 'public' spaces in meatspace, and the function of a space (a place where people get together in public) and its ownership (municipal, commons, private) don't always overlap.

Which doesn't necessarily mean that Twitter should be treated as a town square, because it's clearly something different to that. Similar sorts of concerns about the centrality of private spaces to public use led to PruneYard Shopping Center v. Robins, a California case allowing political activity at shopping centres against the wishes of the operator. That case hasn't been widely followed in other states and countries, though, probably for good reasons.
Ask HN: Gmail users: How did you beat/filter/block spoofed sendgrid.net spam?
There is a very successful spammer that is getting thru gmail's spam filter.

The domain and email content always changes (and the domain itself is something random and unfilterable).

The only common thread for all the spam is that the domain it was sent from doesn't match the domain in the "From:" address. The sender's address, the subject of the emails and the content of the message are different, with "via sendgrid.net" the only common link between them.

Wondering if any enterprising HN user was able to beat this spammer's game

https://support.google.com/mail/thread/60339121/how-do-i-block-and-send-all-emails-coming-via-sendgrid-net-to-spam?hl=en

The above is a long thread of messages on the topic, which Google support has not yet been successfully addressed.
Now we have FerretDB, CockroachDB. I wonder what animal they'll name a DB after next.
When the pandemic started, Zoom only worked on x.org. They've since added Wayland support but googling for it shows the client is still behind on screen sharing. That may just be a harder problem to solve in Wayland without zoom itself acting as a compositor?

https://support.zoom.us/hc/en-us/articles/201362153-Sharing-...

Linux sessions utilizing Wayland can only share an entire desktop or whiteboard. In order to share just a specific application, you will need to launch your Linux session with Xorg instead.
Nvidia can’t improve FP64 performance to near parity without sacrificing a lot in the process, which would make them more vulnerable on the deep learning side of things.
I wouldn't worry about storage. Anyone with root access can modify the sshd daemon (along with imap, pop3, and whatever else) to log all the passwords received.
I never touched it myself, but AMD once exposed the "HSA" interface, which is the AMD GPU execution engine.

ROCm / HIP and OpenCL are built on top of that HSA level. I don't think any docs exist for it, but you can see a ton of references to HSA stuff if you browse the ROCm source code.

--------

It sounds like the parent post discusses details about how AMD GPUs "pick" the next kernel to run. I've been told that the AMD GPU is very advanced at this, but no adequate interface has ever been exposed to the programmer.
Well, what are we to do rather than assume the worst about twitter employees' sexual proclivities ?
>> Is there a comprehensive white-paper anywhere with sample sizes and error bars? Otherwise this seems like an anecdote.

It's marketing. When the vaccine effectiveness is waning the solution seems to be more of it

If it only took 2 days to create the vaccine, why do they not have an updated one? Is there another in development that targets more than just the spike protein? Why is the entire defense that vaccine?
Wouldn't this be a great target for an IR guided missile?
Love this! Thanks for sharing, I have some amazing use cases for this type of work and I can't wait to dig into the code to learn more. The future for CRDT is indeed hot right now and everyone wants it into their app, Google paved the way and now other big names, like Figma, Invision etc are getting on this hard!
That was a low hanging fruit, @jackfr...
Mu: A Human-Scale Computer
I regularly read the meeting minutes, I think it won't even be part of 1.0.
That's actually the second mention, the first is when they introduce the games in section 4:

> Today, computer-
playing programs remain consistently super-human, and one of the strongest and most widely-used
programs is Stockfish.

They also go back to referring to it as Stockfish for the rest of the paper.

An analogous situation in my mind would be if AMD released a new CPU and benchmarked it against an Intel CPU, only mentioning once, somewhere in the middle of the paper, that it was a Pentium 4.
Has anyone seen research around mix and match? As in which is better, stay with the original or get a different booster?

Especially mRNA followed by J&J, and J&J followed by mRNA?

Additionally, is there any benefit to Pfizer followed by Moderna and vice versa.
Zaraz use Workers to make third-party tools secure and fast
In the case of the mRNA vaccines (e.g. Pfizer) it is the spike protein targeted, and that has a hard time effectively mutating because most changes to it make it less infectious. Other aspects of the virus may change but the spike so far has been relatively stable.
Shit happens. My last employer is now mostly on AWS, and mostly in that region, so things broke all over the place yesterday (oddly enough the only service that is multi region was auth). In the past when we were mostly in our own datacenters we suffered as well, so that's not better either. One time a bad DNS update killed every single service worldwide and it took most of a day to properly restart thousands of services. Build complex systems with thousands or millions of things and it's bound to blow up sometime.