skysight-inc/HackerNews huggingface dataset:
Title: Protein region on COVID's viral spike senses temperature, drives seasonal mutation patterns [too long]

> Researchers identify a molecular culprit for the virus's seasonal nature ... Only recently… scientists discovered some lectins play a role in sensing temperature changes in the environment ... [Like in coral reefs,] galectin protein structures sense external conditions and, when it's not too hot or humid, trigger a conformational change in the spike protein of the virus, allowing viral RNA to enter host cells ... [ - when the "flaps" of the "spike jar"] recognize the host cell in the lung - under cool and dry conditions - the jar opens, releasing a fusion peptide that helps merge the virus and host membranes

> the galectin-like structure is a frequent target of mutations because it helps the virus evade or modulate the physiological responses of the host to further its spread and survival ... Bursts of rapid mutation ... often leading to new variants of concern ... were firing [only] in parts of the globe experiencing winter or in high elevation locations where weather remains cool year-round ... most of the seasonal bursts were occurring in the N-terminal region of the spike protein… where the galectin structure is located
The Problem with Meat
The discussion here focused on a single spam account being banned from Twitter, flagging comments and suspecting accounts promoting conspiracy theories validates that disgusting worldview (that big tech has a nefarious connection to underaged trafficking). But as the other comment said I do appreciate your civility. I would like to point out this tedious off topic spiral has the benefit of refusing the engage the dangerous ideas we were originally responding too, and instead pivoting the topic.
Context maters but that was pretty dumb thing to say regardless.
IIRC, it was the operator's (Icarus) fault.
Spot on, this must have been an enormous gamble, because it is not one but two of these 64 pin monsters. Unfortunately the other one (which I've already desoldered, it's lying right in front of me) is cast in plastic rather than with a removable lid so it will take some more magic to get that one to give up its secrets.
US leaders are pluto-kleptocratic stooges and dotards whose only allegiance is to money and power.
Also AdFly does it too. For an example, go to https://firfox.com on Android. Depending on the campaigns active at the moment, you'll probably get pages trying to get you to enable push and or download VPNs or "antivirus" apps. (Especially Norton) On Windows Firefox, you sometimes get the "Your computer has a virus!!! Call our number!!!" sites too.
We have E5 licenses, which security features are you referring to?
Humans have been altering their consciousness for thousands of years. It’s just the intoxicant that’s socially acceptable had changed.

It’s like trying to outlaw sex. You’re fighting evolution.
BuilderIO/mitosis: Write components once, run everywhere
I’d like to add here that the biggest fallacy is assuming rich pay income tax at all, which leftists across the world all seem to universally believe.

I would argue that in 21st century the definition of rich is actually „achieves most of his income through sources which are not subject to income tax”.

Progressive income tax mostly hurts well qualified proffessionals nowadays (people actually working for that income) and as such is detrimental to economy at large.
Sorry I missed this reply. I do'nt disagree, but honestly at this point anything is better than using C for libraries like this.
Do what I do:

Black text on white background (or the reverse, if you’re a philistine.)

Select a color for comments.

Select a color for strings.

Done.

Anything more, and the display looks like someone threw a bag of Skittles at the screen.
I had an interviewer use a test they printed from the internet. I had done that test before and knew all the answers. Came off as a full blown genius! Declined the position though, they didn't offer a genius salary.
Get 100 HART cryptotokens in Hartserver's airdrop
Fines are proportional to turnover, and you don't get fined if you don't have any turnover. People are very scared of GDPR in a way that doesn't reflect the actual enforcement!

You do have to avoid leaking, though; it's effectively a requirement to do information security.
It does not help to call that technology AI. If we do so, now we have to invent some new term to distinguish between that sort of "AI", and the sort of AI that could possibly replace pilots, as the former sort obviously cannot.
> "heavily prioritizing" here means Google doesn't currently plan to fix it until some date in January

Like Microsoft with Windows, Google releases their security fixes for Android monthly. And January 4 is obviously the date for the next one (it goes out at the beginning of each month, and AFAIK the December one has already gone out). So the fix (which might even be ready already) is going to be released on the first opportunity.
The relevant example here is Europe, not Germany. Germany regrets Hitler because Europe split, but the allies defeated it and then imposed their world view on the losers. The Nazis that disagreed were hung, imprisoned, killed or committed suicide. If Hitler had won this thread could have looked very different.
There's loads of books (Lewisohn has some great books), but it's simply not the same as watching and hearing things in near real time.
Not to completely defend gerrymandering but districts are also drawn "oddly" to help ensure minority representation within a system with absurd constraints. If there were more representatives districts would be more granular and localized but because representatives are capped at 435 you have this bizarre situation of needing to give opportunities for equal representation across populations that are spread across a city/county/state.
It's only hard because it's zero sum competition against others doing the same. It seems to happen quite naturally.
Sounds really interesting! Is this open source somewhere? Or perhaps you could share some gist to learn from?
Just in case people from Github are listening to feedback here, please stop blocking search for logged out users? I mean, you're not exactly as terrible as your main competitor gitlab.com which entirely blocks Tor users from cloning repos (unless you add ".git" at the end of URI), but having to login every time i'm looking for a string eg. across an org is the worst. I understand i have to login to publish code and engage in discussions, but login for read-only content is bad UX.

PS: How do you feel about being bought by Microsoft? Maybe some of you feel it's a good time to implement s2s inter-forge federation to plant a nail in the coffin? Sounds like Gitea is on a good way to support it based on ActivityPub/forgefed and it would be sad if Github was relegated to a for-profit walled garden.
It's more likely an elite capitalist thing. Some boss somewhere plays golf at an exclusive club with a regular foursome. He has some work to be done, and each of his three buddies get a slice. They have some friends that could also get a cut. The end result is the golden shower that trickles down. The shops might be unionized, but the contracts are signed at the clubhouse while a boy brings the single malt and cubans.
Work is not the only reason reason someone may use Microsoft Teams. People in school or university use it too, and they sure as hell won't provide you a "school phone".
> In all those cases consumers in Italy would profit, either from fair market or from more tax money.

> 2. Move out of Italian market

this would be a net negative all around. especially for consumers.
Can someone here enlighten me how a default can be "contagious"?

I could imagine that Evergrande bonds become worthless so that many investors will realize losses. But surely no one, or very few, will have invested mostly into Evergrande bonds, right? So presumably, everyone will realize a relatively small loss, no?
>Installing Windows on actual hardware and not just running a VM with virGL.
Hackintosh time with a Lenovo.
I would be happy to get that somewhere in Google someone is either signing off on such a review requirement right now or has done so in the last couple of days.
Apparently employees were told to invest in the company or they would be denied payment/bonuses. Feel sorry for everyone involved in this dumpster fire.
In my experience, the feds don't have the resources to investigate many of the things that the law says they can/will. Usually they look at the most egregious ones, it takes a long time to get around to it.
It would be nice if you could elaborate how are they terribly wrong?
Thankfully the title bar says “unvote” or “undown” so I can know which one I actually hit.
This is rather bad news as an implication for Tinder.
> Or what does 'free' mean?

it depends to whom you ask.

in the US, for a long time, anti-trust was kinda cozy with monopolies - they were accepted as the natural outcome of a free market: the most efficient solution.

In the EU there is more emphasis on market competition, and big monopolists are seen as problematic.
They admit some failures that are not core to the group's existence.

A better example for Linux would be a failure to admit that GPLd / non-stable driver API killed any chances for Linux to succeed on the desktop. Even though theoretically everyone in that community wants desktop Linux to succeed they won't give up their core beliefs to allow it, with the result that the desktop remains dominated by Microsoft and Apple. Meanwhile the Linux world has its own driver schism in the form of Android, which has changed how drivers work totally in project Treble to be user-space and more microkernel oriented.
If you have a design where you cannot test 911 functionality,

or where you can test it, but that testing is not sufficient to ensure the functionality works

then your design is not fit for purpose.
If voting changed things, it wouldn't be allowed.
Quick feedback: that name is not very inviting...
ToS won't save them from a lawsuit in case of 911.
The Nexus 5 was probably the best (in an exciting, non-practical way) phone I ever owned.

However, I found myself in a similar situation as yourself with my Nexus 6P. Newlywed on a beautiful island all by ourselves ready to record some memories. 6P took phenomenal pictures and we were all ready with tripod and remote clicker. 6P just died. Luckily still had the wife's old iphone which managed to capture the moments, but not in all its glory.

Went through one more iteration of Android with a Motorola, that they stopped supporting about 3 months after buying.

As I've said in other posts, the amount of ewaste I generated while in the Android/Google ecosystem is criminal.

Switched to an iphone and haven't looked back. I'm still on the same iphone years later, still getting updates, still chugging along.

In all honesty, I preferred the Android OS, but it's too expensive to tolerate in so many ways; money, time (learning the new UX every time there's an update), environment/ewaste, privacy (google and affiliates vacuuming up all my personal information), convenience (it doesn't breakdown when i need it the most).
> moderate members

Since the Koran is called "the perfect word of god", there is no possible moderation. Reform in Islam means returning to the literal Koran (7th century fundamentalism), ad infinitum.

Calling any Muslim a "moderate Muslim" is an insult, and will get you killed in many countries.

You will not see any debates of the Koran online with Muslims because any non-literal interpretation is blasphemy, punishable by death. (Immediately debates turn into ad hominem attacks to deflect from flying horses, child brides, sex slaves, etc.)

All of the reported crimes in the recent caliphates were approved by the Koran, but the Western media and left has gagged itself.
> Almost always asking for "meaningful" jobs. What even is that? I'll challenge the notion and call it "An inability to find meaning in the available work."

Having an impact. Right now, I'm stuck in a glue code + terraform + maintaining third party code job. 2 years ago I did platform engineering with high impact features for ~100 people across ~20 teams.

> Sense of entitlement, _YOU_ liking the hiring manager? It's your job to get the hiring manager to like you, not the other way around.

Particularly in tech, if you forego extreme salaries, you should pick who you want to work with. You spend more than half of your time awake with these people after all.

> Not knowing your place: You were supposedly not hired into some leadership position to change the world from day 1, you have opinions, they are based on previous experiences, made elsewhere. Shut up, listen, learn, observe and do your best to do what they ask of you, at least the first half year or more, and then start gently providing input and resistance, show that you can do it their way before trying to get them to do it yours.

This is the kicker. You can make things better, but you have to pick your fights, and even with those you need to be careful and have some diplomacy skills to seem helpful rather than a rude know-it-all. Remember, if you call something crap, you're probably doing it close to the person who is responsible for it being crap. They might even know it's not good but were restricted by time. Choose your words carefully.
You are certainly correct, thanks. I hastily typed this out, my bad.
You can retain the aesthetic while also making it less frustrating to use.
That's not it.

Between

[ -f file.txt ] && rm file.txt

and

rm -f file.txt

the latter form is preferrable because it is easier and not as prone to concurrency problems.

Although it should be said that concurrency and idempotency is seldom acquired just by using force-flags in isolated spots, the whole operation needs to take it into account. There are probably more steps involved than just removing one file. The linked article leaves out the bigger picture so it's probably not very helpful. Often it is sufficient to construct the new state under a temporary name and then move it in place in one operation.
Exactly. It is actually a very good comparison I think. When you buy a bunch of domains and squat them without doing anything with them you are paying the "tax" but have no income. It is actually in your best interest to develop a business on your domain to compensate for the costs.

Just like land tax would do. Squatting a bunch of land would cost you a lot. It is would be in your best interest to maximise income from the land to pay for the tax.
All of the fines you list there (I think) are for breaking various law like dumping oil in to the sea, cheating emissions tests, and money laundering. It's good and right that they're fined for those things (though the fines could be higher..) None of them are big enough to abuse their respective markets. The fines are not symmetrical to the fine Amazon has been given for abusing the Italian courier market, and there is no equivalent EU company that could be fined for abusing any US market either. EU companies tend not to be dominant in the US.
Normally these things are tested on a GSM network emulator as emergency calls are specified separately in the standards.

Someone really messed up the compliance testing - probably because it was never tested with fake location enabled.
Copying my comment from the previous thread where it was maybe-defaulting: https://news.ycombinator.com/user?id=Kye

--

Some good explanatory threads I saved when the Evergrande news first broke a couple of months ago:

https://twitter.com/SahilBloom/status/1439920043404546050

https://twitter.com/FabiusMercurius/status/14392189567791513...

https://twitter.com/INArteCarloDoss/status/14389444317349191...
>just look at Amazon total market share in the different European countries and compare to the US.

Since when is Amazon a European company?
The clean meat industry is racing to ditch its reliance on foetal blood (2018)
It's simple. Force it to go through the regular cellular network first, and if it doesn't exist (e.g. because you're on a WiFi-only tablet) or is unreachable then try to fall back to another app.
The HoTT Game
... no, none of these things apply.

1) 'Pointing out to China it's confusing politics with business' implies a total misunderstanding of their posture, their view of governance, and would probably be antagonistically insulting. It also assumes they are operating in 'good faith', which they are not.

'Politics is Business' to them, they know exactly what they are doing and they have most of the leverage so you risk only ire with that tact.

2) 'Thrown this to a shareholder vote' - so this is definitely not the type of things shareholders vote on, nor do they want to, moreover, the 'transparency' and news cycle this would create would be damaging. This is a 'secret agreement' for a good reason. Shareholders do not care about censorship, they generally just want to see performance.

3) What customers outside of China think is completely irrelevant to China.

4) Threatened to pull all manufacturing out. You definitely do not want to threaten your largest market with anything, but yes, you could hint that it might be best elsewhere. That said, it's a magnanimous threat for something relatively small.

5) There is absolutely no way the CCP is going to 'concede' on any of their red line issues. They are dictating the terms of leverage and oversight to Apple and everyone else. Apple has very little room to manoeuvre here.

The only choice cook had was to play friendly on a personal level, kiss ass, make sure that they felt Apple's interest were aligned with China, and to promise to do a bunch of things they were asking, and then hope they go away.

The issue with China's hyper nationalist economic strategy has to be dealt with at a higher level, i.e. US and European political leaders and industry leaders working together on one page.
This website is broken in my firefox.
Yup. IQ tests, personality tests, psychological profiles, not happening. It's a load of pseudoscientific hogwash which hiring managers use to justify their own biases.
My ISP has a dynamic prefix, so it changes "willy-nilly", sometimes per day.

With pfSense, the issue was primarily two-fold. First was the fact that all the firewall rules and such did not support dynamic prefixes. Major PITA right there.

Second was the DNS server, that is, when using pfSense as a DNS server I couldn't figure out how to prevent it from sending the public IPv6 address to clients. Thus when the (public) prefix changed, DNS stopped working on the clients.

Some of this might have improved since I last used it, but I switched to OpenWRT and haven't looked back for a second.
I hope you'll understand I'm not arguing against you. I can totally understand the adversity, and by all means people can easily use it as a bias, but it merely gauges how good at "if X then Y" one is, which in turn reflects on how clear the job at hand should be. It's not about being smart/er than others, it should be just one datapoint in a sea of tens of datapoints in the search for "a good fit". And all you're looking for are red-flags, not as many checked checkboxes. Then again, any tool can be misused. Point taken.
Did you speak with twitter directly? Who provided you with this excuse?
> “So what I was suggesting originally is that Buf should try to explain what they are doing that these other systems failed to do…”

I was having a discussion online yesterday about writing research papers, and this exact line of argumentation was noted.

As I recall, the marketing version is called a ‘white paper’.
You can't downvote comments if you have less than 501 karma, and the downvote button doesn't appear on replies to your own comments. Plus, there is no downvote button for stories, just for comments.

EDIT: It originally said "less than 500 karma".
thanks!
So nice to follow up on the source!!
Will the People's Bank of China be paying Evergrande's foreign debts (aka bonds)? How many derivative products were created off those in other markets? Will it be as bad as 2008/09 when Mortgage Backed Securities and their derivatives collapsed except this time it is Commercial Mortgage Backed Securities?

Just asking questions in case anyone closer to those business areas wants to chime in. I doubt there is transparency coming out of China about this.
Ahaha, you should have left saying you found a better job after staying in a Holiday Inn last night.
>Bull

No Europe would have no search-engine to replace.
It's simple

Who's next? Get out of that as fast as possible

Enough people think like that, hey presto
Projections were chosen for a variety of reasons. For example the Mercator projection distorts the size of things far from the equator, but it does preserve local bearing and shape.
This is wrong in every way.
Megacorps own the US government. It's called lobbying and super PACs. Extreme corruption so ubiquitous, most people forget about it.
Psychological Consequences of Infidelity and the Ways to Recover
Recovering from breakup pain is sometimes tough to overcome, especially if you still love that person. Thus, breakup recovery is not so easy. But, no worries. We are here to guide you well on how you can recover breakup.
One firm defaults, all their investors lose a bit of money. Now that they've lost a bit of money, they will have less money to lend to other firms. Now those firms find it harder to service their debts (eg they were planning to roll over their loans with other loans), so some of them default.

A firm in the real estate business defaults. That makes people think other firms in that business will also default. So then all real estate businesses find it a a bit harder to borrow.

Add leverage. I buy a loan from a number RE businesses, but I don't just use the money in my pocket. I borrow it from the bank at a lower rate than what I receive from Evergrande. They go bust, bank asks me for money, I need to sell my other loans in the RE firms. Those loans will go down in value, reflecting higher rates and making it harder for the firms. This credit cycle is described by Soros in his books. Works both ways actually, when things are good it's the reverse.
Admitting that old parts could still be viable would undercut the entire foundation of the consumer electronics industry!

Even the "Muh Power Consumption" argument for "new" hardware often fails in the real world: the CPU or even "the digital controls system" is a trivial part of the system's power input.

Before long, people will begin to realize that latency issues have been the biggest problem for quite some time and begin to look at all those things Intel would never attempt to address them. We might find some of these older chips had more potential than was allowed to be realized at the time.
As the article states, papers are mostly career advancement tools and scientists are incentivized to put the least amount of useful information into them they can get away with. Real scientists mostly learn from their instructors who possess all the jealously guarded institutional knowledge.

Yes, it is very broken.
There's an (ex-) Navy air base called HMS Daedalus, better than HMS Icarus