skysight-inc/HackerNews huggingface dataset:
Matt Might chronicled experiences with his son's rare genetic disease. Perhaps that will give you some ideas.

Hunting down my son's killer: https://matt.might.net/articles/my-sons-killer/

You may also want to email him. Anecdotally, I believe the rare disease research community is small and willing to listen to outliers.

University department page: https://www.uab.edu/medicine/pmi/matt-might

(Edit: fixed urls, typos, grouping.)
‘Your profit fuelled genocide’: Rohingya sue Facebook for £150bn
Stepping back a bit from the specific question further, a PCP isn’t the best partner for a rare disease as you’ve noted as well. As you seeing in responses, there are many people willing to help that are well informed. There is typically researchers, associations, and niche communities that will help one keep up with the latest research. If you share more specific information, I or someone else may be able to help direct you towards resources.
RTFA, it’s entire point is that the decline was present in cities without Giuliani as well. The correlation was with reduction in lead, not dim-witted politicians on the left nor the right.
Alcubierre was the first person to connect this idea to a spacetime metric which obeys the equations of general relativity, with actual math.
For someone used to working at nanoscale, 1µm seems enormous! There are entire free-living organisms that could fit inside that warp bubble.
The Gram series has been phenomenal in my experience, especially considering the price.
Brilliant idea to convert something boring to elegant. It opens a lot of possibilites for developers to make something cool out of boring stuff people love.
In that post Vitalik actually says he thinks there's a high chance block production will end up centralized. If it happens, what's to stop the government from going to the dominant block producers and forcing them to impose limits on the kind of data a block can store? Then dragging them to court or enacting some other form of political retribution if they fail to do so.
Coming up with the concept isn't particularly important. Alcubierre actually did the math.
We found Omicron genomes in my county's wastewater. Give it like, two days and it'll hit the news.

SOURCE: I work in a leading U.S. wastewater testing lab.
I doubt if many enterprises would survive this level of catastrophe.
I’ll bite. A winery could sell ownership of wine stored or wine yet to be made. The purchaser, if sold via an NFT, could resell that ownership with no interaction with the winery until claiming the wine at a later date.

This means both parties no longer need any relationship between the initial sale and claiming the eventual goods. The winery will simply be able to wait for someone to return with proof of ownership at a later date.

If the winery gave out certificates or built some app it would need to verify and maintain that. With an NFT there is very little work on their end.

Ultimately this turns these type of products into highly liquid assets. This will greatly increase their value to a potential customer and the initial purchase price. Which will make the winery more money for the wine it sells.

This can effectively be done with anything that can be claimed at a later date after initial purchase.
This is where Apple shows itself as a leader in privacy, as their location data is encrypted from what I understand, at least after iOS 15. This protects you from rogue employees, at least this is what is claimed. At Life360 it would be very easy for many employees to creep on someones location history.

My understanding is there isn't really much auditing in the way of this functionality, and that customer support can easily go through your location history with zero to minimal auditing. They use an 'impersonate' feature to log into your profile on a web-app when supporting customers typically, which would make it easy for a bad actor to track you. Or they could just buy the data straight from the broker.
It's a self-fulfilling prophecy. If your userbase doesn't think it needs improving, people with unfulfilled requirements will go somewhere else. Which may be a good thing if you want to limit the scope and serve a specific market well. But it may also leave you behind with shrinking usage and few new users. (since they prefer to start with the overall better option)
Well you’re completely wrong. The vast majority of a CEO’s compensation is tied to the success of the company (often >90% comes in stock).

It’s the difference between life changing money (early retirement, vacation anywhere any time, etc).
In Karachi too IIRC
That’s a lot less wasteful than you think.
> i said nothing of sort.

Didn't I quote part of your message in my reply that says exactly that?

> The Kozaks - runaway serves, criminals, and just various "free will" people - were there precisely because it was wild unpopulated area.

They were common people that fled form populated places of Ukraine into unpopulated lower Dnieper areas to establish self governing communities. Obviously, these people needed to come from somewhere, unless you suggest they materialized in Zaporizya (since we are talking about Ukraine) out of thin air. It would also be reasonable to assume that such misfits constitute a significant minority of general population, so in order to have tens of thousands of kozaks you probably need hundreds of thousands of people populating nearby towns and villages.

> For the language - i stated my personal opinion.

Okay, lets go over your "opinions" one more time to address all points presented:

"I'm half Ukranian myself and watch some modern Ukranian TV including in Ukranian..." - the languages are somewhat similar in your opinion and it looks like you can understand both. Okay.

"...and i fail to see it as a separate language." - this is where it gets weird and I mentioned several other similar languages and asked for your clarification if you also don't consider them a "real distinct language" (which would also be a very weird opinion, from linguistic standpoint). But I guess this part of you message can still reasonably be considered an opinion.

""funny not-a-true-language" which is very close to the language of Russian peasants" - here you are apparently presenting some historic fact, which is in reality Russian nationalistic fringe talking point and is not supported by scientists from either Russian Empire, Soviet Union or modern Ukraine (I provided links and quotes). In fact, highly educated early 18th century Russian Lomonosov who studied in both Russia and Ukraine and should be able to immediately recognize the "language of Russian peasants" doesn't consider it such. Here it seems you also feel entitled to your own facts, not just opinions.

> It is the first time i see somebody excludes Novgorod from Russian history.

I don't think stating that Tzardom, Russian Empire and, consecutively, modern Russia is a continuation of Duchy of Moscow, which was and unimportant outpost during Mongol invasion, constitutes "exclusion" of Novgorod from Russian history. I just think that you position "Ukrainian making shit up about Rus since Russia is the obvious uninterrupted continuation of Rus because Mongols turned back hundred kilometers before reaching Novgorod or something" is rather strange. Let's just consider it another opinion and leave it at that.

> Sounds to me like you'd be ok if that dynasty was called "Vladimirovichi" (or "Svyatoslavichi" or "Igorevichi" for the Rurik's grandson or son) instead of "Rurikovichi". I don't see what is the difference though.

No, I'm totally okay with calling the dynasty whatever. I'm just saying that any person in 2021 who claims to _trace_ his bloodline from Rurik is full of shit.
> Output: Digital services, site subscriptions, digital assets, in-game items, NFT's representing real world assets held by trusted companies (wine, event tickets, tokenized securities).

> None of this requires oracles and exists today.

While I only mentioned oracles specifically, I should have clarified: I'm referring both to oracles (making queries to external data sources and providing the results to the blockchain), and to external code that interprets data stored on the blockchain and acts on it. I'm not sure if there's a name for it in common use (I'd call it something like a "performer"). Either way, the issue is the same as that with oracles; whatever decentralization or smart contract guarantees you had on the blockchain disappear as soon as you have external code interpreting blockchain data to then make decisions in external systems (digital services, site subscriptions, digital assets, in-game items, NFT's, etc). If oracles provide inputs to the blockchain, these non-blockchain pieces of code provide the real-world outputs.

Example: even if somewhere in the blockchain I can prove that I should own something in the real world, it's still up to your site/service/app/whatever to honor that through external code. If it doesn't honor it, I'm stuck relying on traditional legal means to intervene, just as with any other standard contract. That legal system – as flawed as it is – tends to work for contracts written on the back of a napkin, stored in a SQL database, or coded in a smart contract (though that's probably the most questionable at the moment).

If I'm wrong, please correct me, but I've been interested in this stuff for a while, and I haven't found anything that actually solves the fundamental problem of oracles and the interpretation of blockchain data. That problem is important because it undermines many of the primary selling points of smart contracts.

> Your mistake is thinking that just because the base layer is decentralised that we're somehow not allowed to connect to companies we choose to trust

So, honest question: why care about the base layer being decentralized if in the end, you choose to trust those companies? What did the decentralization do for you in that interaction?
No matter how we do it, we end up violating causality. Even if we can only create micron-sized warp drives, there are still some huge implications. We could probably build a machine that executes nondeterministic algorithms, for example — doesn't matter that P≠NP if we nevertheless have a way to solve such problems in P time.
Lots that's wrong with this, but taking it at face value: isn't this sort of like saying smokers die younger on average because of misinformation? Fundamentally it's not true. The reason is different priorities. People like to tell themselves that ignorance must be the reason people disagree with them, and if only they were educated they'd see the world as I do. This is silly. People have different priorities, which could include valuing activities more than the increase in mortality risk that they incur. It's not ignorance, it's a difference of opinion, and its destructive to pretend that there is some universal version of "right" that we simply need to educate and inform people enough and they accept.
Tying Emmett Till to #MeToo is nonsensical at best and astonishingly repulsive at worst.

Till was literally slaughtered because of the false accusation. The woman faced no consequences.

The #MeToo movement was about the opposite: men who were credibly accused of a crime and not investigated at all. The woman then has her character assassinated and, often, her career destroyed.

There is no analogy here. They are unrelated events from vastly different times. No man has been slaughtered because of #MeToo. Very few have even stopped being wealthy.
I did say little flamewar. :)
Apple brought it on themselves with their anti-repair stance. Third party repair companies are literally begging them for parts so they can service Apple products. In other industries, there are a large number of quality technicians who can service consumer products without a problem.
Mobile, AL has some pretty big left turn channels they dug out the median for. New Orleans tends to make U turns past the intersection.
FWIW, Monobook remains my preferred Wikipedia UI, and perhaps my favorite UI design period. A true marriage of form and function.

https://en.wikipedia.org/w/index.php?title=Main_Page&useskin...
I like it, now add "forward vision screens" with cameras down either side of the car and 50cm up off the roof.

That way, when stuck in slow traffic, I can look for oncoming traffic before turning out at all.

Maybe car driving will be the "killer app" for AR.
>The conference version of the talk has a constantly animated background that makes the video hard for some people to watch.

A completely unrelated anecdote.

When I clicked the link, I was greeted with a beautiful black and white and blue page, perfectly indented.

I scrolled and looked at the ascii and thought how great it was to just see a web page again.

Then I looked at the source to see if they had designed any extra special formatting and was greeted with <style id="brave_speedreader_style"> and realized I had Brave Speedreader on. I was a little disappointed when I turned it off and the hyperlinks turned pink.
This is only if you buy through a partner, which isn’t necessary for most small businesses who aren’t getting volume discounts. In those scenarios, it probably always made more sense to buy through the admin portal.
http://www.jofamericanscience.org/journals/am-sci/jas150419/...
> You essentially dump your cache when this happens, but you can do it.

Never heard of this and it makes no sense. The cache is pretty decoupled from the CPU pipeline. I saw a similar comment from someone discussion RISC-V mentioning that ARM/Thumb interworking is costly. I have no idea where these myths come from - really bizarre.
The spread outside of Iraq to the rest of the Levant is most certainly due to neighboring countries being destabilized.
Also very common in New Orleans.
You either hear from outliers then or there is systematic oppression of this innovation in you claim to hear of. If the government was filled with innovative smart people we would see innovative results.
Related note: I spent a while trying hand soldering, hot plates, and hot air rework to solder SMT boards. I should've just gotten a cheap toaster oven like in the article. I guess I was scared off by all the people insulating them and installing PID controllers. Totally unnecessary for me. I just stick in a thermocouple and vaguely follow a reflow profile. I'm easily getting 100% successful boards down to 0402 and 0.4mm QFN.
Yeah, I think your best option is to identify the protein containing the mutation. Then contact experts studying that protein. Most researchers love to hear from outsiders
Good advice for someone experienced, terrible advice for a beginner.

If you want to kill someone's love for playing and have them hate their favorite songs, make them use their completely untrained ear to listen for chords they don't even know through layers of amp effects, pedals, and editing.
I hope Facebook does not guzzle same amount of energy as Bitcoin.

We don't need another nation level energy guzzler for a spy/disinformation network.
Then why does Amazon do so well in other countries?
Lock Free Threading
Hm, I seem to be able to copy and paste the mus produced by pdflatex or by using pandoc to convert from LaTeX to HTML. Perhaps they're using something bespoke.
But we've made tools to overcome human limitations, so that is not really the issue. Apple just doesn't want their products repaired - or at the very least it is not a priority for them. Its just not a good look when they pretend to be "green" while not contributing towards the elephant in the garbage bin - e-waste.
My experience was with the UDP tunneling service and some general CDN stuff. Once you get past the published pricing then it’s sales calls and stuff like that.
Specific plug for Will Byrd's mediKanren
and Matt Might's group in general
they are the real deal.
(source: I have worked for other deals).

For more just start learning the tools...
I have not checked in on them for years now
but "BioStars Handbook" was up & coming

[] https://github.com/webyrd/mediKanren
[] https://biostar.myshopify.com/
People scared of this should consider: Are you sure the camera in your device isn't on right now?
As long as it’s not operating at a loss or using taxpayer money, then that’s fine. Otherwise it’s using taxpayer money to destroy competing businesses.

We don’t really care about businesses operating private militaries so the army isn’t a good comparison.
I think anyone who has survived as a taxi driver in Manhattan will tell you robotaxis are patently impossible in many zones
There was an interesting article in NYT the other day - https://www.nytimes.com/interactive/2021/12/01/science/coron...

> To better understand the coronavirus’s journey from one person to another, a team of 50 scientists has for the first time created an atomic simulation of the coronavirus nestled in a tiny airborne drop of water.

> To create the model, the researchers needed one of the world’s biggest supercomputers to assemble 1.3 billion atoms and track all their movements down to less than a millionth of a second. This computational tour de force is offering an unprecedented glimpse at how the virus survives in the open air as it spreads to a new host.

And they look at things like how mucins, water, and calcium atoms interact with the proteins of the virus particle.

> This discovery may help explain how the Delta variant became so widespread. Delta’s spike proteins have a more positive charge than those on earlier forms of the coronavirus. As a result, mucins huddle more closely around them. That attraction could potentially make the mucins a better shield.
A sort of toy solution for an arrangement of spacetime valid in general relativity allows faster than light travel but requires all sorts of things which are varying levels of probably impossible / this doesn’t exist.

Some experimentalists playing around with the Casimir effect (very real) which has to do with very close together things being pushed together while in a vacuum due to quantum effects of a vacuum found something in a simulation that looks quite like the toy solution that allows faster than light travel, involving things a few millionths of a meter across.

They figure you could actually build this contraption which is essentially just a little ball in a little tube and test its effects on electrons to confirm that they really can create tiny warp fields and study them… or they could have just made mistakes or found a way to invalidate some physics.

It doesnt seem like there’s a lot you could do with a micro scale warp field as the effect it relies on really depends on scale, but it is an interesting possibility.

Like most cases of “huh, that’s weird” it’s probably nothing, but it might be something, definitely worth the research funding to build the little device, but hold off on your vacation plans to Alpha Centauri.
are you selling these??
Community wise, yes. It seems to have gained some momentum.

From a technical point of view, I'm not so sure. C++ still interoperate easier with C than Rust, if only because you can normally just include the headers and be done with it.
(Although as the article says, there are some cleanup to do.)
America & the west has been way way in the lead with (communist-ic) giving away of chips designs, open source. It'll be interesting to see if CAS really is able & willing to contribute.

One place i think they could really make a mark: there's a lot of un-core that is still pretty hard to replicate, inaccessible. Trying to make more interfaces available, commodity, rather than bitterly guarded IP that a scant few companies own & rent out (that i believe even folks like SiFive simply go shopping for)... that could really change the game, help make chipmaking much more diverse again.

Otoh simply cranking out good solid risc-v core innovation is also needed. It'll be interesting to see whether such designs are flexible, iterable, evolvable, or fixed & monolithic in mature.
Yep, the only place I’ve ever interviewed at where i had multiple no-shows in a row for my interviews. I had to notify my recruiter multiple times of this 30 mins after my interview was supposed to start, and she wasn’t even aware that my interviewer didn’t show up. The process that was supposed to take a month at most stretched out to almost 3.

Not even mentioning the whole bait-and-switch, where I was led to believe that i was interviewing for a position at Twitch, not at at Amazon itself. Turns out, after I got suspicious of it all and asked quite a bunch of very specific questions from my interviewers, it was revealed that it was actually for a role on an AWS team that worked as a partner for Twitch. After me asking the recruiter if I just misunderstood it all from the start, I was just met with “well, it is still working with Twitch, just for AWS”. I was kinda mad after spending those miserable months interviewing, especially since i made it clear to the recruiter from the very start that I am solely interested if it is a job at Twitch and not Amazon. Lesson learned though.
Those goalposts got moved years ago
I'm really curious, if you would be so kind as to share, can you give examples of what contributes to this stress you have?

No problem if you don't feel comfortable to, I'm just curious to hear what kinds of problems people are having.
Getting performance bonuses while not having the ability to change anything is the same thing. If you can’t see why tying the incentives to the ability to affect outcomes is important, I don’t know what to tell you.
This is my semi-educated guess as to what's going on here. Beware that semi-educated guesses are sometimes worse than uneducated ones, since they are more plausible and not necessarily more correct.

The Alcubierre warp drive requires both positive and negative curvatures. Positive curvatures are "easy" to make, since mass and energy bend space positively. Negative curvatures are typically said to require negative energy to produce, but the full story is thankfully more complex.

The universe, despite being filled with mass and energy, is roughly flat. That means that the natural bending of spacetime, without any stuff inside it, has to be negative - otherwise all the mass would make it extra positive. If you believe the consequence of vacuum energy in QED, that the fields filling the universe are VERY heavy, even when no particles are around, then you must believe the natural curvature to be very negative indeed.

So, it stands to reason, if you want to bend the universe backwards, take the weights off of it - really off of it, in this case using metal plates to forbid certain vacuum fluctuations, and let it unbend itself.
as long as nothing you're including includes that in c++, it shouldn't be an issue at the linker level, and thus not be an issue at all.

at least in general - if it's something that can't handled by a c shim then you might have an issue.
Read the whole post carefully. Your question is answered in it.
Hugged to death. https://archive.md/qKJ7I