skysight-inc/HackerNews huggingface dataset:
The point of a vaccine is to not get the actual virus, or at least to minimize its effects if infected.

When you are infected with anything, you do not always develop anti-bodies. If you do develop anti-bodies, they might not be effective at actually stopping you from being re-infected.

Everything about the virus can mutate, but the virus will always target the ACE2 binding site. The spike protein can mutate to bind to it differently, but it will always require a spike protein.
(Biology is Analog, not digital)

Thus targeting the spike protein is more efficient as it will be highly conserved.

There is a video series that does a nice job of breaking down how your immune response works:
https://youtu.be/lXfEK8G8CUI

The vaccine is more effective at developing anti-bodies for the spike protein as it is the only protein exposed during the process.

An analogy that has helped some of my family:
The virus is like a missile, and your immune system is a anti-missile system. Regardless of what the missile looks like, it has to have a warhead, and that warhead is what really defines what the entire thing does. So, if your defense systems targets the fuel of the missile, the enemy can change what fuel it runs on and evade your defense system. They can change the material it is made of, the shape of the overall device, change the propulsion and navigation systems…but the warhead can only have minor changes as it has because it it makes too many, it becomes ineffective and is no longer a threat.

Thus, if your defense system targets the warhead none of the other changes matter.
What did you even think that assembly language was, if not a machine-specific language? What you wanted to learn does not currently exist; the closest modern analog might be (at the moment) WebAssembly.
> Fair enough, but what are you going to do? Round them up in camps and forcibly inject them at this point?

Given that up until very recently there was quite little in way of actual restrictions on unvaccinated in Germany, this is really just a false dichotomy.
For me, getting better at managing my personal finances made a huge difference. It is way more feasible to do things you like while sacrificing (some) salary if you have managed to build up a nest egg. It doesn't even have to be a lot of financial skills, even just the concept of "wealth is cumulative money in minus cumulative money out, so if you spend as much as you earn you'll never get richer" is very useful to internalize.
To be clear, Kubernetes does not know anything about draining traffic from pods or nodes. See my comment elsewhere.
Linking to your own blog isn’t disallowed, and in fact “write a blog post about the thing and then link to that” is the right way to handle this.

I think the rule that may be tripping you up is “Please don't use HN primarily for promotion. It's ok to post your own stuff occasionally, but the primary use of the site should be for curiosity.”

That rule is focused on avoiding self-promotion. For example, if you’re working on a cool new idea, don’t just post a new link to your site once a week. But writing a blog post to dig into an element of something Typora has changed is pretty clearly fine.
Came here to say this.

You have the skills to consult. Pick an area that:

* you feel is likely to grow
* you like
* you are good at
* you feel is underserved

and start writing and speaking about that (even at a local meetup). After a month or two, reach out to former colleagues who might have the problem you want to solve and ask if they know anyone who does.

Hiring junior devs will give you the opportunity to mentor but may force you to wear your sales and/or PM hat more than you'd like. You can start down this path by subcontracting and see how it feels.
The back pain-industrial complex is an incredible web of interlocking interests where no part has an incentive to really cure anything long term. The canonical expose of this system is the recent book "Crooked: Outwitting the Back Pain Industry and Getting on the Road to Recovery"[0], where a seasoned investigative reporter surveys the entire industry in detail. She gave a nice summary on this podcast[1]. And she has a detailed section on the breakthrough ideas of Dr. Sarno, and how he was ignored for decades.

The book is in three sections. The first section is a very depressing history of back surgeries and devices attached to the back, that almost uniformly fail after a few years, leaving the patients worse than they started. The second section covers various exercise and bootcamp approaches, including the MedX lumbar extention machine invented by Arthur Jones, who also invented Nautilus machines with adjustable strength curves via cams. The MedX lumbar machine was the only device that could isolate and recruit the inter-vertebral muscles, which have been shown to be weak in patients with lower back pain. The machines came in a medical version[2] and an exercise version[3]. The back pain industry saw that the medical machine was working much too well and cutting into their income, so they had insurance companies stop paying for "exercise" modalities, and that approach died. The third section of the book is on the wide range of body manipulation techniques, like pilates, etc.

[0] https://www.amazon.com/Crooked-Outwitting-Industry-Getting-R...

[1] https://informfitness.com/podcast/50-outwitting-back-pain-ca...

[2] https://youtu.be/Ao1CkBbe2nw

[3] https://youtu.be/1Z-FyeG7pqY
It reads like a horoscope and it is worth as much.
> if/when the lira rises 15%

(Sure it is just an expression, but: here is a reminder that is something falls 15%, it recovers previous state through gaining ~17.5%; if it falls 20%, it needs to increase 25%; if it falls 50%, it then has to double...)
What is the disease?
Swish works for person to person transactions, physical store payments, and I've also seen some companies starting to use it for monthly bill payments (ie, send out a paper with qr code, user scan it with app and signs it, and bill is paid).
Yes, because all of these expensive industries are paragons of free market economy.

The industries where the government stimulates demand (everything from mortgage rate deductions to section 8 and from creating and backing loans non-dischargable in bankruptcy to well, pretty much everything in healthcare) and restricts supply (everything from zoning and environmental regulation to excessive regulation, like in healthcare, to directly running things), are expensive, as summarized crudely in this famous chart [1].

In fact, we are now experiencing what happens when government restricts supply and stimulates demand on most things - lockdowns + stimulus (in some cases, also things like tariffs, canceling pipelines, etc.). It evidently "works" exactly the same way as e.g. healthcare "worked" for a long time; on a smaller scale due to relative size of the interference vs the interfered-with segment of the economy.

Oh and of course, price to income ratio in the USA still remains in line with OECD averages, and considerably lower than some far less "neoliberal" countries [2]

In general, size of the middle class in the free market hellscape is far larger, and the incomes are higher [3]
Moreover, the "hollowing out" of the middle class is due to the migration primarily to higher income brackets in constant dollars [4]

What really is happening in the segments where things are not going as well as they could, is not neoliberalism.

The 1st part was described by Ortega Y Gasset almost a century ago; he describes one aspect of "mass men" as being similar to spoiled children (or aristocratic heirs), who are born into the world of prosperity built by someone else, and so take it for granted and assume they are entitled to it. It's hard for me to believe that about 1920ies, but I guess I haven't lived then and he has; it's easy for me to believe that about the West in the 2020ies.

The second part was described e.g. by Thomas Sowell a decade ago - politicians force corporations to give people things. Whatever benefit the people get from that is ascribed to politicians. The negative outcomes (at the very least, someone has to pay for the benefits) is blamed on the corporation. There's historically been a name for this model of governance [5], and it flourished in 1920ies, which might not be a coincidence.

[1] https://www.aei.org/wp-content/uploads/2019/01/cpichart2019....

[2] https://data.oecd.org/chart/6xsL

[3] https://www.pewresearch.org/fact-tank/2017/06/05/through-an-...

[4] https://www.pewresearch.org/social-trends/2015/12/09/the-ame...

[5] https://www.ocregister.com/2012/06/12/thomas-sowell-obamas-n...
We have communist parties in Germany such as the Marxist–Leninist Party of Germany or the German Communist Party. However they have no almost support. Communism is about the ownership of the means of production as in people are not allowed to own factories. You will find almost no German who supports that. Not even the Linke supports that and instead hides behind a nebulous "overcoming capitalism".
The most polite RTFA ;)
I'd like to know this too. My brain constantly registers it as (incorrectly) being as a result of having been downvoted.
How long did it take them? Could you have gone in bought a ton of stock at old prices and gotten at least some of your 15% back? Apple stuff resells pretty well
It's very odd to write CCCP in an otherwise english paragraph in latin alphabet. YOu would be better understood to write USSR or better just write Soviet Union.

(For those unfamiliar, CCCP is SSSR in cyrillic alphabet).
The recipient token can also be a phone number capable of receiving a text message.
the 2nd generation Shuffle moved to a more miniature clip-on design and required a dock to charge and sync, I gather that’s what OP is referring to
Pica – Cravings for non-food items
I like that this seems to trend towards newer movies, a lot of other recommendation platforms seem to ignore year of release.
Are all stablecoins looking dodgy? Sure, centralized ones, particularly tether you could argue so.

But what about decentralized stablecoins such as Dai?
Vaccines don't make you immune to the virus. The reduce transmission and symptoms, and practically eliminate death risk. But you can still get the virus, and can still get sick.

Source: currently qpositive, mildly sick, doubly vaccinated.
Bitcoin lacks reversibility, which turns out to be a necessary property for a payments network to cover all use cases.

This (as well as expensive fees, until lightning, and wild price fluctuations) is why it never really caught on as a SWIFT/Western Union replacement.
The winners curse also creates the curious corollary that one should probably bid less, the more people are in the auction.
Is Twitch "free"?
How to finish your side projects and make money doing so: 5 Actionable Tips
It's an easy target that neutralizes point of entry, but that also adds a great deal of selective pressure for mutations of the spike proteins, which we already know have an effective/successful mutation rate much higher than the rest of the virus. (Likely for the same reasons.)

But the ACE2 receptor is relatively lenient in what it will pair with compared to the immune system.

So a spike with multiple mutations is more likely to be able to continue infecting cells via ACE2, than the mrna-vaccine-induced-immuno-response (targeting only the spike region) is able to block it.

And because of this "fuzzy" matching, less than perfect mutations can perpetuate until other helpful mutations occur.

But each of these mutations is also a step closer to evading detection by the immune system, so they can be helpful over multiple iterations of mutations, even if there's no selective pressure/benefit provided per mutation. That it can continue to bind to ACE2 is enough, until it reaches a point where the immune system doesn't recognize and must re-learn that target.
Big Syrup strikes again.
No tech stack should take up two years of time to learn. Two years sounds fine for a large program with internships... but it should have a much broader curriculum rather than focusing on one platform, especially one that is not a leading platform in the industry.
One of the interesting points he makes is that forwarding ports with IGDP is a small part of UPnP's functionality.

By equating the two and discarding all of UPnP's other local service discovery features, for fear of IGDP specifically, perhaps we are throwing the baby out with the bathwater.
Similar age and circumstance but not in the USA.

The saddest part for me is the companies that just throw you a take-home exercise without even bothering to phone you first. You apply to a certain position and then, say a week later -or sometimes more-, they simply send you an email with some programming task to develop.

Frequently they are not small tasks but full projects which require multiple days of work. Just a few days ago: delivering a full web application to manage "map layers", with a DB, a back-end, and a "user-friendly front-end with a nice design"; testing included and all put into Docker containers, and a working demo somewhere published automatically from the repository.

And I mean, it's not just the assumption that you will spend however long it takes you on this for free, but that you will do it without even having had a simple conversation with them before.

----

Anyway, what I really wanted to say was: Good luck in your search. Stay sane.
This is very interesting. I'm trying more to become a person like that. It's way healthier to accept emotions than try to always run away from them
1) Finish your work
2) get a job that doesn’t require tons of meetings
3) use slack on your phone

If you meet these requirements you can cut out all the bullshit from your day and just focus on the meaty part that you actually get paid for.
Why not contracting/consulting? Or starting your own startup/project? You can focus on the tech and role you want, have minimal meetings, avoid office politics, work the way you want, and define your own path. I understand salaried positions have distinct pros though.
Heh, I think my daughters generation will just replace them with emojis.
Ah thank you! I was thinking China but that's CCP. I was wondering if I was missing something from history.
There is something wrong with blockchain games
In my mind, this is the pinnacle of keyboard craftsmanship.

It hits a lot of checkboxes for high-end custom keyboards, but combined with Alps-type switches and totally custom-made keycaps, this really sets a new precedent.

Personally, I'd rather use something with ortholinear or column-staggered keys. If I was a row-staggered person however, then this would be it.
For anyone curious about treatment for latent toxoplasmosis, this was an interesting read: https://journals.asm.org/doi/10.1128/mBio.00381-19

I’m a former practicing veterinarian, had 13 outdoor cats as pets as a child and several indoor cat pets over my life, and so almost certainly am in the 1/3rd of humans who are infected/affected.
Yeah but it’s more fun to actually hold silver or gold! Not very good investment but I’d recommend most people to get $200 worth just for fun!
> There is no free market for many things in Canada. This is sad because the population is not exactly the wealthiest and these people are being fleeced.

There are people on both sides of every transaction. Canada skews protectionist, especially around dairy, but that doesn't mean people are being fleeced. Farmers who take higher wages as a result live better lives, and the marginal delta in prices isn't really felt at the checkouts. Certainly in some cases, but definitely not in all.
What does Typora have over ghostwriter, remarkable, zettlr, or apostrophe?

I mostly use Zim-Wiki but if I'm doing markdown these seem to provide everything Typora for free.
Its people arguing silly semantics. VSCode is an IDE, features are organized by extensions. Intellij's products work the same.
There's a lot of information that is only available to MLS members. Zillow used to not have access to this information, but they slowly brokered deals with MLSes around the country to get it.

One example: The MLS in Austin, TX recently banned publicly sharing a home's sold price. https://www.zillow.com/austin-tx-78701/sold/
Yeah that's straight-up false. I've spent a lot of time in the eastern provinces and in the United States over the last few years. I think rather than opinion, this would be a good opportunity to dig up some data.
Love that the top page after homepage is /moveis/horny :D Felix Dennis was so right!

Anyway, love everything about this whole open startups(1) thing. Really amazing to see what happens behind the scenes!

(1) https://baremetrics.com/open-startups
Even here in Europe this is a thing now because they seem intent on making our money worthless with negative interest rates. As a consumer I have very little financial confidence left.
I don't think it's planned, it's just how things tend to turn out. At least for the three startups I've worked with.

If you're really good at cranking out code before your fledgling company runs out of money, that doesn't necessarily mean you're good at people management or leading. At a certain size, your company is going to need those skills more, and won't want to keep someone around at a C-level salary who's just slinging code.

The founding eng directors I've met all separated for different reasons. One took a buyout after the company was purchased, another had a side business that became profitable and helped find his own replacement, and the last one had his role downgraded when the company hired a CTO, and just got another job.
It's misleading at best to state that difference without specifying that it's a difference in unadjusted crude rates, and without the caveats to drawing conclusions about vaccine efficacy from them. From the footnote on page 24 of your source:

Comparing case rates among vaccinated and unvaccinated populations should not be used to estimate vaccine effectiveness against COVID-19 infection. Vaccine effectiveness has been formally estimated from a number of different sources and is summarised on pages 5 to 8 in this report.
The case rates in the vaccinated and unvaccinated populations are unadjusted crude rates that do not take into account underlying statistical biases in the data and there are likely to be systematic differences between these 2 population groups. For example:
• people who are fully vaccinated may be more health conscious and therefore more likely to get tested for COVID-19 and so more likely to be identified as a case (based on the data provided by the NHS Test and Trace)
• many of those who were at the head of the queue for vaccination are those at higher risk from COVID-19 due to their age, their occupation, their family circumstances or because of underlying health issues
• people who are fully vaccinated and people who are unvaccinated may behave differently, particularly with regard to social interactions and therefore may have differing levels of exposure to COVID-19
• people who have never been vaccinated are more likely to have caught COVID-19 in the weeks or months before the period of the cases covered in the report. This gives them some natural immunity to the virus for a few months which may have contributed to a lower case rate in the past few weeks
The NES contains 2k of RAM. Although you can extend that in the cartridge I doubt games use garbage collection.

Why would you anyway? It’s such a basic, predictable game. There’s a fixed size playing field that contains only one fixed size moving object.
Sure, there's a reasonable argument to be made at a high level that it's all advertising. However, I think the GP is getting at something important. With enough granularity you can see a qualitative difference. Some of this advertising is only self-serving and some of it is in service to the customer.

When JetBrains gives me helpful tips on how to consume PyCharm, they aren't doing it out of the goodness of their hearts. They want me to keep using PyCharm. However, it also serves me because it makes me more productive when I use PyCharm. When Netflix advertises to me that a new season of my favorite show is on Netflix, likewise: they want me to keep subscribing. But it also serves to help me get more value out of the subscription I've already purchased.

These activities contrast with the game developer using psychological tricks to get me to purchase in-game currencies at unreasonable rates that I otherwise wouldn't purchase.

There's a spectrum with fraud on one end, and, I don't know, something like genuinely helpful information on the other end. Likely different people will place any individual advertisement on a different place on the spectrum.
> while locally produced goods and services should remain more or less unchanged.

What usually happens is that since oil is denominated in USD, the price of fuel and transportation rises when a currency weakens and that increases the price of locally produced goods as well.
Toxoplasma research is pretty established and the conclusions above matches fairly well what I learned 20 years ago.
Thanks. In that case I think the rule is mostly fine. At least it would be if there was better options for micro-blogging on the spur of the moment ;-)
I always understood the usage of "to cry uncle", but never understood the origin until you described it this way. I guess, being the oldest cousin in my family, and not being the kind of person to beat up my younger cousins, it never came up.
You're forgetting Lebanon
Hmm, I had assumed that they were all getting downvoted!
If you stop to think about it yes it is pretty odd, but enough people do this that I don't have to think twice when I see it. You'd definitely wouldn't see it in formal writing, but informally it's not uncommon. A quirk of cross-cultural transmission maybe?
FDA report finds all-cause mortality higher among vaccinated
> Natural immunity targets the whole virus, so whatever immune-escape such a virus evolves, it would have to be far more comprehensive to have a significant effect.

I never thought about it that way. That would mean, if the virus evolves a more efficient ACE-2 binding domain that the mRNA vaccines fail to recognize, the vaccinated population would be more at risk than the unvaccinated population who has been previously exposed.
This is a critical concept that appears to be poorly understood in at least the web development circles I run in.

It reminds me of one of my favorite Bill Gates quotes:

"The first rule of any technology used in a business is that automation applied to an efficient operation will magnify the efficiency. The second is that automation applied to an inefficient operation will magnify the inefficiency."
So Texas funds education at the state level via property taxes? That sounds surprisingly progressive of them.

Washington state does something similar, though it’s more of a subsidy. Education is still mainly funded locally, but the state kicks in with its own funding for poorer districts, so Seattle property taxes subsidize schools across the state in Spokane.
Through this lens "supply chain problems" starts looking like a rather convenient scapegoat for preventing consumers from purchasing your wares before their currency becomes realized as worth less and your prices go up accordingly.

This is effectively what's happened with my inability to buy an IKEA table for months... it was constantly out of stock, and it's still out of stock, but its price has increased 15% from when I first attempted buying.
Probably some forced course laws that demands prices be defined in local currency.

If you ever lived in countries with irresponsible central banks like Brazil or Argentina you'll notice there are often laws to dissuade you from using the crappy local currency.