skysight-inc/HackerNews huggingface dataset:
NOT a ELI5 but this should give you a reasonable understanding.
Why are RNA virus mutation rates so damn high?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107253/
"RNA viruses have high mutation rates—up to a million times higher than their hosts—and these high rates are correlated with enhanced virulence and evolvability, traits considered beneficial for viruses. However, their mutation rates are almost disastrously high, and a small increase in mutation rate can cause RNA viruses to go locally extinct"

Some bloke who was the head of Porton Down aka Public Health England when commenting on the London Plague pits found when digging the tunnel for Cross Rail suggested RNA viruses have a single helix so are prone to high levels of mutations unlike DNA which has the double helix checksum to reduce mutations.
This is probably the episode. https://www.bbc.co.uk/programmes/b04cnps9

How Messenger RNA vaccines work.
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

mRNA is not the only solution, some dietary changes can create a chemical based attack vector as your body has evolved to cope with extremes.
This just one example of many different chemical attack vectors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413200/

There is also this
https://news.ycombinator.com/item?id=12451198

But I cant find the hacker news link on a paper from MIT which also suggested a 3 day fast reset the immune systems "memory" which was a novel way of wiping vaccine triggered immune system responses and probably isnt what you want to do if you believe in the covid vaccines, but if you are an anti-vaxxer forced into having a vaccine, then it could be a way of wiping its effect from your body if the study was accurate.

Now before you go out fasting, just bear in mind you will be depleting your body of many things like the vampire chemical glutathione (NAC, Glutamine & Glycin) which depletes as you age. Its called the vampire chemical because it whitens skin and makes you sensitive to light amongst other things so there might have been some truth to those vampire legends!

I know Vit D is mentioned alot, the Welcome Trust in Cambridge reversed engineered the human genome back a few years back and suggested there were 2776 Vit D receptors, most concentrated around the immune system genes, but the VDR has a zinc finger so you need to take zinc and both A & D will get you closer to hypercalcemia so that brings its risks, but in 1959 the scientific community did work out if you take A & D you need to take K to mitigate the risk of hypercalcemia. And if you are elderly, you should consider taking taurine as this helps the body manage the fats in your diet (bile) amongst other things, which explains why the elderly generally absorb A & D less easily or respond less to supplementation compared to young people. You'll find taurine in some wacky places in the body.
Doesn't need phase 3 trials? That's gonna be great! How soon will other people be able to get it?
Any discount only applies to the traffic that exceeds that number.

In other words, if 151 TB total is consumed:

* first 150 TB at full price

* next 1 TB discounted
I remember reading years ago (pre Uber) that there should be more taxis in the New York City to help people get around.

They quoted a professor who had, according to the article, the most accurate model of NYC traffic given a large number of variables e.g. number of commuters, taxis, buses, subway frequency etc.

A key take away was the a taxi (or Uber/Lyft etc) is much WORSE for traffic than a commuter car. Commuters drive in, park, leave their car all day then leave.

Taxis are constantly circling and looking for fares. IIRC the impact of a taxi was several multiples of the impact of a commuter on daily gridlock.

Now, I love Uber/Lyft for all of the regular reasons e.g. allows people in under-served areas get transportation, senior citizens and the disabled with more access etc.

The traffic impact, however, seems pretty substantial.
Sell the default search provider to bing for a few billion dollars. Same way Firefox makes money.
Here's another gem:

int allocate_memory(void)
{
int *matrix;

if (!(matrix = malloc(sizeof(int) * 9))) // this is short for matrix = malloc(sizeof(int) \* 9; if (matrix == NULL)
return NULL; // the malloc is now protected,

return matrix;
}
Lots of words, very little said. How do you think e.g. docker "intercepts syscalls"?
The wave of condensed cars is moving opposite of the direction of travel of the cars.

The high density region of cars is moving backwards.
Zvi has been blogging approximately weekly about covid since the beginning, and has a very good track record.

Look through some of his posts and see how they've held up? https://thezvi.wordpress.com/?s=covid

(On credentials, it looks to me like you ended up with his credentials specifically in the context of game design? He's also worked as a trader, which is some practice at turning unclear information coming out in real time into good concrete predictions.)
> The only thing wrong with dynamic typing is it’s slower and is harder to debug, but people are able to be way more productive in these languages you call bad.

Not even close to "only thing". Dynamic language is a net loss of productivity once you reach a certain level of scale. Refactoring a codebase with millions of lines of code in a dynamic language is an absolute nightmare.

Opinions vary at what level of scale this happens. My personal experience is that once you hit just a few thousand lines of code that dynamic typing is a drag on productivity.

There's a reason things like TypeScript are increasingly popular.

I don't care what language first year CS students use. I care what languages I'm forced to deal with on a day-to-day basis!
> These are not mutually exclusive.

Didn't say they were.

> I just want to find high-quality projects

Of course everyone does, but one won't be able to tell the difference at first, and so its best to jump in on any project related to a particular field of interest, start discussing/asking questions with people in those communities (without trying to allocate any of your financial capital), start analyzing the contracts code, and you'll slowly find out about more projects/ideas/concepts.

> It’s hard to navigate the spaces sometimes because it’s hard to know the status quo.

Well, what the status quo is isn't really important in the exploratory stages, because no matter where you land, people may have different opinions on what that even is and it will be up to you to determine what's the best course of action for yourself.
It isn't a political issue to not do studies that require doing things that actively and intentionally put people at things we know are highly likely to put them at risk of physical harm. The world decided this was unethical long before the current political climate.
There are also offerings that are already regulated and licensed by the FCA, so as long as you stay within their consumer credit guidelines it's not a "risky play".
All these discussion about APR and napkin math and installment is missing the point a bit, in my opinion.

My problem is not even that Edge collects unnecessary and allows what could be called a most intrusive third party add into its browser per se, I am mostly amazed by how incredibly tacky this looks and feels from Microsoft's side.

Like, imagine buying a Lexus and discovering they are advertisements for a cheap off-brand energy drink plastered on the interior.

I find it straight up incredible that Microsoft somewhat achieved to overcome the meme status of its browser after what, fifteen years, and now this? Passing on the the crown of being the lowest common denominator tech joke to someone else, gaining a little bit of market share and even one or two positive reviews in respected outlets...only to risk it all in this weird move of behaving like a shady car salesman for what must a be a double digit million deal at most, right?
Correct. This Chevy Bolt https://www.cnbc.com/2021/09/20/gm-to-begin-fixing-recalled-...
Is there anyone who believes this on HN? If so, I'd love to have a discussion about why you feel this is the case. I'm young (24) and am performing very well in the workplace. I'm actually much more productive when remote than when I go to an office and waste a bunch of time on commuting.

A lot of this "people need to socialize" stuff feels very patronizing to me. I think socializing with coworkers used to be seen as a risky thing to do, now it's encouraged. I don't like the idea of building my entire friend group, or a majority of it, around who I work with.
“Everything in moderation” ;)
A friendly reminder that, if you don’t like Amazon’s ethics in how they run their retail business, vote with your infrastructure dollars — that’s what’s paying for the show (well, that and their advertising business everyone ignores).

Amazon’s AWS margin is everyone else’s opportunity.
Your case is covered by the "rarely" word in my comment.
Wombo Dream – AI Powered Artwork Tool
The traffic isnt moving backwards but the traffic jam is.
Bob Metcalfe repeatedly predicted a "gigalapse" which he defined as a loss of one billion hours of Internet connectivity. Bob would say look at how fragile this all is, and his point wasn't (although at the time it would too often be portrayed this way) "the Internet will fail" because Bob isn't actually an idiot, but it also shows a substantial lack of foresight anyway. Of course ~everybody will have the Network, the Internet is the Network, and so then normal sleep is an order of magnitude worse than a "gigalapse" yet happens every day and we don't even care.

The "gigalapse" seemed like a big deal because proportionally a billion user hours in 1995 is everything doesn't work for days, or most things don't work for several weeks... but today of course it could also be everybody in the world is inconvenienced for about long enough to make breakfast. Oh no.
Network Admission Control (NAC)
No, US devs really do make a very large amount of money. Both the mean and median wage in US are over $100k. That number is probably on the low side too, as the government BLS data doesn't seem to account well for stock grants, bonuses, and benefits.

https://www.bls.gov/oes/current/oes151256.htm

Ed- typos
Probably half R&D (no issues there), half sales and marketing.

One thing - is their free service offering a sales and marketing expense or is that in cost of revenue.

Last quarter they did 80M in sales costs (vs 40 in R&D and 28 in G&A). Sales costs were 50% of operating costs and close to 50% of revenue.

Amazon has everything blended, but sales runs 7% of revenue.
When people on the East coast but goods from China/Japan/other pacific nations, those goods typically move through west coast ports.

So the backups with LA and other ports are because of increased demand on the east coast, west coast, and everywhere in between.
Python’s strength isn’t being the best at anything. Its strength is being top 2/5/whatever in a ton of things. Moving to julia for this just trades some pain points for others.
The simple answer is public policy always lags the public therefor is always a bad idea to implement NPIs. Public policy should be concentrating on increasing hospital capacity, therapeutic/prophylactic distribution. Presumably never on "lockdowns" or travel bans or masks. People will lock themselves down if it's bad enough, and more importantly at finer granularity and with more equity.
Operating Systems and Algorithms at GT are top-notch. Some of the best in the world. That's one reason they are consistently ranked in the top 10 CS programs in the world.
Please do it!

Tbh, while I'd welcome it, I'd prefer rigorous Carbon pricing with dividends
You actually want to be exposed to the virus (after vaccination) during the summer and if possible as often as possible after a successful exposure. It's the only way forward. You can't lock it out forever, and you need to play catch up with it as it evolves or by the time you get it your immune system won't know what to do with it
> You can't dismiss the fact that hiring python is hard.

I deny that hiring Python is hard beyond “hiring is hard”.

> You think you're getting a good programmer, because they know all the leetcode tricks,

Unless I want someone for a role that is very much like reproducing leetcode tricks, I don't think I would think someone is good for it because they are good at those. In fact, leetcode is mercilessly mocked as being almost completely irrelevant as a positive signal for hiring, though it may be useful as a filtering tool to reduce an overwhelming volume of applicants to a manageable one where high rates of both false negatives and false positives, but some slight advantage over just randomly discarding applicants, is tolerable.
They run clinical trials on them to make sure they are safe and effective.

https://www.cdc.gov/flu/vaccines-work/effectivenessqa.htm

Manufacturers guess which flu strain will predominate and start working 9-12 months early to capture the data for approval.

There is no way a new Covid mRNA vaccine will be approved with safety and efficacy data from a clinical trial. That will be take months to complete.
I was surprised when browsing PaperSpace.com (a gpu host for ML training) that Fast.AI is now considered a "legacy" software? I've built a few small classifiers / ML projects but not really enough to really branch out of an intermediate tutorial.

With how quickly these frameworks change it's overwhelming to keep pace! Anyone have advice for solid frameworks that can reasonably leverage GPU's without too much heavy lifting?
If it's grossly inefficient compared to rail, does it mean it is grossly more expensive than rail + last mile truck? If yes, why does anyone still use it? If no, in what sense is it inefficient?
Sr News Programming
This is not just a "remote work" thing. It's simply how people are today -- even in person. It's a cold, transactional world.
If contacts are a problem, DeOxit is your friend. I have no affiliation to the company. I'm simply a long-time user.

https://caig.com/deoxit-d-series/
My comment hit -3 and no one wrote a critical counterpoint yet.

I took a guess at why it was downvotes. Nothing more.
Because bandwidth isn't the only AWS product, but you can't buy bandwidth for cheap from XYZ Inc. and connect that to your AWS account. That's not technically possible, you have to buy it from AWS.

So instead of using the cheapest vendor, companies use AWS for a ton of reasons (broad support, everyone knows how to work with it so it makes recruiting easier, hundreds of features, etc...) and their high bandwidth bill is worth it.
In the US, you can hardly get them. Amazon was restricting them to medical professionals until recently, and all the local stores have been out of stock since spring 2020. Now, if you currently look at Amazon for 3M N95, you'll see that a lot of the purchasers are doubtful that the products offered are genuine.

We've had two years to increase the output of N95s and expand the hospital facilities to handle severe COVID. Almost nothing has been accomplished.
The TV will still need to update its certificates and work on corporate wifi, so there should always be a way to feed it your own certificate and MITM DNS. I think, anyway.
Well I live near Newark and currently there are a bunch of boats there that came from Asia in a month, via Suez & Panama. Its much more efficient than trucking across the whole country.

https://www.myshiptracking.com/vessels/pelican-mmsi-63601548...
https://www.myshiptracking.com/vessels/gudrun-maersk-mmsi-22...
https://www.myshiptracking.com/vessels/ever-lovely-mmsi-5630...
This is absolutely not true. Every public figure left of center in the country commented viciously about the racist, stupid travel ban.
I will bet the next 1000 years will look a lot like the last 1000.

We like to think we live in unusual or unique times… we don’t.
I use starship and it’s been pretty great and very fast.
I'm making them up. It's speculation.

But I also said I agreed with the precautions being taken, so what's the issue?
"The CloudFront free tier is a full-service free tier, meaning customers can use all CloudFront features, such as support of website images, media workloads, and APIs, without service restrictions or data type limitations."

That's a pretty direct dig at cloudflare with their service and data type limitations :) So this does seem pretty cloudflare targeted.
I would argue that if you really understand binary search, then you understand half of CS Theory. You can apply that to DP, graphs, networks, etc. and solve most problems efficiently.
https://archive.md/iithw
Why do you feel you need to bring up Amazon retail, ethics and voting with dollars to a discussion about AWS data transfer price reduction?
> If the encoding is that corrupted, if you choose 20 bits at random to examine, there's less than 1/1000000 chance that you chose one of the corrupted ones.

Is there a typo somewhere here? I'm confused what you're saying. So if my message is 40 bits long and you randomly pick 20 bits to examine, there's a less than one-in-a-million chance that you choose a corrupted bit?

Why? Wouldn't that be an almost 100% chance (= 1 - (20/40 * 19/39 * 18/38 * ...))? Or in terms of whether you recovered the correct value, wouldn't that be a 50% chance (20/40)? Sorry this probably sounds really dumb but I feel like I'm not understanding what you intended to write.
"Since Sanger's departure from Wikipedia, he has been critical of the project, describing it in 2007 as being "broken beyond repair". He has argued that despite its merits, Wikipedia lacks credibility due to a lack of respect for expertise and authority. He has also criticized Wikipedia for what he perceives as a leftist and liberal ideological bias in its articles."

https://en.wikipedia.org/wiki/Larry_Sanger

Recent HN discussion:

https://news.ycombinator.com/item?id=29333776
Yup, turned out that inventory isn't pure capital waste after all. It's an insurance policy, an investment in stability.

Bring back inventory.
After reading this post I decided to go buy an old Android phone and install pmOS on it.

But then I looked at this list. Is there really no device that supports a camera? This seems like an incredible omission if true. Am I misreading this list?

https://wiki.postmarketos.org/wiki/Devices

Is there a good device for another distribution that at least has calls/texts, camera and network support so I can browse the web?
It's not just Python, Julia is dynamically typed too.
Yup. Pretty amazing how that went away pretty quickly despite China violating the Montreal protocol.
No idea. Time will tell but a high number of mutations is not ideal.
Deer seem to be big carriers also, 80% infected in one study

https://nypost.com/2021/11/02/deer-identified-as-widespread-...
At the California ports experiencing the worst of being unable to fulfill high demand, the robotics space is intentionally diminished by union activity. Rotterdam stores, moves, and transfers with much greater efficiency with robotic assistance.

However, I don't support injuring workers with tech efficiency advances - it's morally wrong.

But I do wish tech and labor everywhere had better discussions on how to introduce efficiency while also, and more importantly, preserving gainful employment and creating better work experiences.
People post scientific studies, and you repeatedly go back to the same person who has shown an obvious political bias against masks and vaccines to attempt to debunk them.

I'm just feeding into the problem by replying to you, but none of us can expect any discourse with you to be productive when you are working from a position that relies on believing someone acting in obvious bad faith.
Your link is broken, but if you're talking about that FT chart with the title that starts with "A new variant is spreading rapidly..." then I might be able to to put you at ease a bit, without quibbling about "too early to tell".

It is a time vs percentage share of cases chart, comparing Beta, Delta and Omicron. Omicron is growing very fast in percentage share relative to Beta and Delta. But Beta and Delta were competing with other variants when they first emerged, whereas Omicron is currently not. So its percent share is growing fast.
It's vendor lock in.

"Hey should we build our company on cloudflare? Their egress cost is cheaper"

"No, AWS has far more features and besides, we get enough bandwidth for free because we're a small startup"

Fast forward 5 years, your company has grown and is buying a 10 terabytes a month of egress, but you can't switch platforms now, you're too far dug in and integrated with AWS.
I always thought "big Ο" was uppercase omicron. That would make it consistent with Θ and Ω.
In a game of telephone, the further you get from the original source the less reliable the information becomes.

https://en.wikipedia.org/wiki/Game_of_telephone
So you've retreated to the "everyone that disagrees with me is a conspiracy theorist" argument?

Thanks for the discussion.
You'll have to pay extra for the "enterprise" TV ;)
We need this in USA, too.
As long as it makes you comfortable you should wear a mask. However it makes me uncomfortable to wear one. I've never worn one. The fact you are scared doesn't mean I should have to change how I live. You should change how you live in order to better cope with your fear. Expecting the world to change for you is setting yourself up for disappointment at best.
Sure, and generally the shorter the term the larger the APR. Makes it sound a lot scarier, huh?
This is a pretty big change for smaller players. AWS region free outbound tier is now 100GB instead of 1GB, and more importantly, the free tier is perpetual.
Kstar Nuclear Fusion Reactor Further Improved
Cloud flare is the snowball coming down the mountain at them. Why not try to take a dig?

You think they would be lowering their cost if it wasn’t for R2 or whatever they call it? Of course not!
Nice, my Georgia tech OMSA classes have finally reached real world instance of hearing something I learned about. Thx
Could pay for lifetime. Would never pay for monthly for this service.
A free list of 60 no-code tools you can use on your business/sideprojects
This list of 60 no-code tools includes some tools that you can't find in any no-code websites.

Grab it completely FREE!
This is like going to a supermarket and complaining that the plastic bags for you to store your shopping in cost 10 cents which is a 8000% markup, as if plastic bags are why you're in a supermarket
I see that you are not from California
Canadians rocked by celebrity groundhog death coverup
New York Times won’t ban fossil fuel advertisers
This was amazing to read.

Everybody will cry out loud whenever they hear anything about crypto or blockchain, yet, give them some "Zip Money" from an *app* and they're suddenly all right.

What a time to be alive...
Kinesis Advantage2 keyboard. Without it I would not be able to work as a software developer.
Anyone want to share a blurb on what they do?
Linux in late 90's was a beast. FVWM+RXVT used far less memory and CPU than the tipical SUN Station and with a fraction of the price.
I'm doing great without one. No need to worry about longterm risks from a rushed vaccine. 1 year does not equal 10. Ever.
Anarchism implies no state control.

Dictatorships, monarchies, oligarchies, and corrupt politicians worsen situations. Putting power back into the hands of the community and it’s workers shouldn’t do that.
Strike for Most People
Hence the suggestion to remedy the lack of use by using them.
> Security is best when it is uniform

So when web traffic is uniformly not encrypted that's more secure than if it is encrypted by varying degrees and implementations?

Tbh your complaint reads along the lines of "Perfect is the enemy of good enough". SSL may not be perfect, but it sure as hell is better than running pretty much the whole web in the clear.

Particularly as pretty much all of your complaints do not really have anything to do with SSL itself, but rather in how Chrome surfaces a lack of SSL a certificate and how your hoster handles installing certificates.

Both of which are things you can personally change something about.