skysight-inc/HackerNews huggingface dataset:
I think I get what you mean but I don't agree on all fronts.

1. that compounds derive from some difficult to handle gas is only a problem for the process chemists. In this case because the TFA-based precursor is available this is not a problem. Though technically, the production of that commercially available TFA will probably have involved F2.

2. Though indeed there are quite a few toxic compounds that incorporate fluorine, such as 5-fluoro-uracil, fluoroacetate etc this is not quite a general rule, as there are also plenty of non toxic medicines and materials that incorporate fluorine. It seems decently compatible with life compared, certainly compared to some other elements or classes of compounds generally.

3. specifically concerning nucleoside/-tide/-base analogs I wouldn't quite pin their cytotoxicity on fluorine, as a class these will tend to be toxic because they are similar enough to nucleosides to get where they need to be but dissimilar enough to cause problems and make systems that deal with nucleobase derivatives malfunction. Instead of 5-fluoro you can also put 5-iodo, 5-TFM, sulfur, alkynyl, etc there and get antiviral like, cytotoxic compounds

In any case, when it comes to this specific pfizer drug, I would say the presence of some fluorines is not a production problem and certainly not a toxicity red flag. For example, Derek Lowe, whose amusing post on some of the more dangerous fluorine chemistry you cite, also has the following to say about fluorine and medicinal chemistry:

"We med-chemists just love our fluorines - as long as we don't have to use, like, fluorine itself to make them - because they armor-plate parts of our molecules against being metabolized and can change the binding profiles of the parent structures like nothing else can."[0]

[0]https://www.science.org/content/blog-post/new-ways-fluorinat...
I think golang makes for an interesting example:

Your program won't compile if you have unused imports, or even unused variables.

Which is low-friction for maintenance. You're not going to have to worry if deleting something is unsafe.

But this strong-arm implementation of a lint means that iterating on code meets high friction. It slows down developer iterations as you have to comment/uncomment in order to compile. -- "But if you use some tool it's not so bad" is advice I've been given, which strikes me as the same as "automatic loading isn't so bad if you're using an IDE".
I'm really not suggesting active suppression, but rather simple, Occam-compliant inaction. COVID19, for example, is not really the first of its kind - just the first that was clearly going to produce profits if addressed. And lo, magically, it was.

Mine was not a conspiracy-innuendo, but rather a simple critique of profit-driven research in health-related sciences. Humans can do wonderful things when they work together, so it's rather sad that we seem to do that only when there are riches on the line.
Some things are obviously useful for yourself. Indeed, sharing them can often be effort with no expectation of return.

Writing a book for yourself may have some sort of forcing function to understand a topic. But mostly I wouldn’t write a whole book to do that.
Git’s internal model is trivially simple: everything is stored as objects addressed by content. These objects can point to each other. Additionally names can be associated with objects and which object a name points to can be updated.
Probably one you don't want, an Oster long slot toaster, so I could toast those big sliced sourdough/sheep herders loaf bread slices (does a great job too). It died once so far (a few bits of crumbs on the electromagnet prevented the circuit from closing), had top open it and clean it out, works great again. Most toaster suffer from that over time.
Chewing Gum More Fatal Than RUM, Says Tesla (1932)
> It actually makes sense if you learn the full command but makes zero sense when you google individual common operations

I call this "hacker tunnel vision". It is a state afflicting a lot of programmers at the top of their game when it comes to writing end-user API and documentation. It can be summarized by "it is so obvious that people will think I'm mocking them for explaining this"
Kuhn's post seems to be based solely on ideological arguments and seems to be mostly critisizing the company's actions rather than the license. I will personally disagree regarding the unsatisfiable obligations part. As for restrict how the program can be used for completely legitimate, legal, and ethical purpose I have also heard it about AGPL :p
It's automation software for macOS https://www.keyboardmaestro.com/main/
Hmm, GitHub Network is much more than log. I think "GitHub Commits" page mirrors git log.
How is this useful?
If you have finite budget and finite researchers, you allocate them where are the most ROI is. Researchers aren't settling sitting idly by.
Too bad Windows 7 has "only" lasted for 11 years. The reason I switched to Windows 10 was just to play a resource-hungry game (FS2020). The level of privacy is such on Windows 10 that even with the browser, webcam or microphone off I have the impression that MS knows what I'm humming or even thinking.

Every 3 days, as mentioned elsewhere, it will harass you into linking your computer account to an online account and then push OneDrive sync upon you...
>Obviously, some merchants do benefit from dissuading credit card use

Or they just prefer to deal in cash so they don't have to pay as much in taxes.
Never? Everything changes.

Do you honestly expect China will become more humble and less bold over time?
Why is it too late?
Yep, let's do that. Then on the other end we can write opinion pieces like this:

https://carnegieendowment.org/2012/03/06/why-fukushima-was-p...

The great thing about opinion pieces is everyone's always right in their own opinion piece.
It seems this thread is just a bunch of people using this news as an excuse to criticise people who don't take the vaccine rather than any rational discussion of the topic.
User of the software vs developer of the software

As the user of an IDE, I should be able to develop my own modifications for it. Any users of my modifications should also have that same right.
good for Sqlite to simplify on their tools. But:

Git has a lot of weird stuff and fluff, but that doesn't mean you have to use all of them.

For instance, I try to almost never branch and use deployment flags instead - then you can always rebase and maintain an extremely simple commit history.

Simple >> Complex.
Wasn't there a suspension of the rule related to the pandemic?
> I can be pretty sure you'll get less drug R&D.

You'd get more R&D. There were way more new drugs released before Bayh-Dole.
> why would you want to be in VR all day?

I think the benefit of VR is not just about social stuff, but our ability to augment/improve certain experiences.

For example, fb's worksrooms is a virtual office. There is no digital watercooler, but it offers a virtual desk and a virtual conference room. You have a private space that is distraction free to work in, and a great space for remote workers to simulate an IRL meeting. I've used it only for social calls, but we did plan a trip (so kinda like a business meeting) and the whiteboard/monitor is super useful especially when combined with the ability to point and see who is talking.

> he internet does not require you to isolate yourself physically the same way VR does.

VR today is terrible when you have to walk around because it breaks the "illusion", but for tasks that take place in one spot and are immersive/require focus (offices, etc) they can be great. If you live alone, and/or in a small house, why buy a big and expensive TV and not just a vr headset?

I agree its a bad comparison. VR is like a desktop computer IMO. Its not comparable to a phone, in use or convenience or power or whatever. If you want to sit and focus on a single thing as a "destination" activity, VR may be better. (example of destination activity: "go to my desk/office to work" "go to tv room to watch tv" "go to arcade to game", etc.

People want the metaverse to be like the internet. I think its circular and silly to discuss. Its like wanting the web to be the internet. The web is kinda the internet, but also kinda a subset. Most of the internet for most people was APIs or crud apps with a HTML gui. We did get smartphone app guis but they're not as well interlinked, and now we may get a VR/AR gui. Ideally, you'll be able to inter-link between experiences, but as mobile dev showed us, its unlikely to be as natural and rich in linking abilities as HTML based "www" is.
I suspect this is highly subjective. I learned git when I barely understood programming. Figured out the basics and went from there. It’s never gotten in my way. I don’t deny it’s been confusing at times, but I’ve used svn and hg and had a similar experience. People seem to have highly variable experiences of it - maybe due to how they think, or perhaps an element of chance and first impressions?
Renewables got cheaper to the point where it's not competitive

Counter-argument: Wind and sun are unreliable

Counter-counter-argument: Why not build 10x the amount of wind and solar if it's so cheap, and automatically break the circuit when not needed?
The dirty little secret is that renewables are consumable. They wear out and have to be replaced. Like discount shoes: they're cheap, they don't look good, and you throw them away after a while.
Are you claiming that Pharma companies don't want to make money and are therefore not investing more in R&D?
Once I understood that git was basically a DAG of filesystem snapshots enforced by hashes then everything started to make sense very quickly.

I'd even argue that hiding this fact is what makes all of the other CVS a pain in the ass to use because they are trying so hard to hide the truth from their users.
Isn’t weather too gloomy? It’s very difficult for people who can’t thrive in non-sunny often weather.
It’s all about communication. I think of a POC as way to communicate what it is that needs to be created. I think a document is another way of communicating what needs to be done. Mandating one or the other seems like a fools errand to me since each one has strengths and weaknesses.
Eventually a power source can power anything, but choosing good first customers is important. Usually, v1 of the product is expensive and flaky. So you need first customers who are willing to pay extra for the privilege of being early adopters, or for PR value. Data centers seem like a good bet here.

As you get better at mass producing the machines, the cost will come down and you can make money selling power to the grid at much lower prices.
Senior developer is the the equivalent of an O-3 maybe.
"We will bury you!" -- Khrushchev, November 18, 1956.

Those who get in the way of China’s ascent will have their “heads bashed bloody against a Great Wall of steel.” - Xi Jinping, July 1, 2021

nice
I think that's fine for solo development but as soon as you have a real collaborative project -- which, supposedly, is why you need a peer-to-peer vcs, then there comes a time when dev A is working on some feature for the future, and dev B is debugging on an existing release, and now you really need branches because B's fix is going to need to be pushed out ASAP but dev A's feature is still being worked on.
What would someone have to gain out of this? And who? The biggest barrier to nuclear power is the initial cost and time required to turn a profit.
The International Monetary Fond, not known to be populated by treehugging hippies with naturalistic fallacies as a major character trait, published this beautiful graph: https://blogs.imf.org/wp-content/uploads/2019/04/eng-april-4...

Nuclear now costs three times as much as solar & wind! And that data ist from 2017. Both technologies are also not showing any slowdown in improvements, while nuclear tends to get more expensive.

The trend for batteries happens to be extremely similar.

Nuclear is dead. Maybe people arguing against it in the 1980 were wrong. Maybe it’s safe. None of that matters, because it’s simply too expensive. And, increasingly, it’s also just too late: a nuclear power project takes 15 years, which is twice as much as we have.

The only energy that still keeps it in the news is this weird tie-in with the culture wars, where, apparently, a certain segment likes nuclear power because it’s big, ugly, dangerous and sciency. They are living the future of the past.
Right, we saw many things with the accuracy of whoop, but hopefully their new one is better than before.

We will speak to their team for a partnership
Directed Acyclic Graphs and SHA hashes are not hard concepts to understand. From that every commands make sense very quickly.
More expensive?Yeah, probably, because the alarmist message about nuclear has been the rhetoric for decades.I would argue nuclear is greener, yes, than some renewable sources like wind/solar (of whom the effects to our atmosphere and fauna are still vastly ignored or not documented enough).

Many people focus on carbon or some other element that in vast amounts is damaging to our climate, but forget the fact that animals,birds,and life in general can sustain and even undo the effects of pollution in some cases.
A 0-carbon atmosphere is rendered useless if there are no birds, plants(which by the way USE it) or life (besides humans, presumably).
People should look at the individuals/entities that push for climate _alarmist_ (not awareness, a distinction to be understood) messages and think beyond the political and economic gain that those entities benefit if such messages are to be followed.
>Use maintenance mode software:
>Angular over React

author lost me at this point
... and in the same time they build even more hydro and other renewables, with even more money. china is just using everything to stop being that dependant on coal. it's just that their governement just does not care and builds everything, because china needs more energy every year. they quadrupled their energy needs in the last years.

just because they build nuclear does not mean that they don't build other stuff.
Society doesn't look out for me.

Government doesn't look out for me.

The company doesn't look out for me.

My boss doesn't look out for me.

Even my "friends" and "family" don't look out for me.

If I want somebody to look out for me, I guess I'd better do it myself. Don't like the way I look out for myself? Maybe you shouldn't have made it necessary for me to do so in the first place through your own mercenary indifference to my needs, desires, and welfare.

I ain't your friend. I ain't your family. I'm here to do the job and get paid. Of course I'm going to put myself above the organization. If I dropped dead on the job you'd have my job posted before my obituary, and you think I give a single little fucking shit about you or your company?

Robert Glazer can eat my unwashed mercenary ass.
The lit crit community were into function, NC was all structure. Skinner was way ahead of them, and his time with his book Verbal Behavior. Language is a behavior guided by no special processes relative to other human behavior
Sirum (YC W15) is hiring a Chief of Staff to help make medicine affordable
I’ll believe that when it is not taxed like a security.
I was a student at the time, and well, didn't handle it particularly well in hindsight. Not sure I can help much with that aspect.

What I do want to say though, is if she makes it through this round, fingers crossed, ask the doctors where the cancer she got might spread to, and be very observant of changes in those areas.

I now have the sad experience of losing my dad and seeing two close friends lose one of their parents due to cancer that spread. Common for all three was that the spread wasn't detected because it happened in another area in the body, and nobody connected the dots.

In my dads case, after a year on asthma meds (he never had symptoms asthma before) the cancer was accidentally discovered in his lungs. Then the doctors say "oh yea, if the type he has spreads, it's to the lungs"...

In my dads case it would have been terminal either way, they couldn't remove it from his lungs. But it would at least have saved him over a year of needless pain and suffering before they figured out he didn't have asthma, and possibly slowed it down more.
I'm far from convinced by this article.

It's starts by saying that it's not comparing git and fossil but just keeps trying to throw generalities at your face how fossil is so much better and smarter than git.

It sometimes compares git and all of a sudden compares github or gitlab, no reason given. So what is it about, comparing git, github or gitlab?

Apparently git is to complex for developers, sorry but I have yet to see a developer not managing to work with git. Either I've always worked with geniuses or this is a non-problem.
> because those kinds of features requires the back end to execute Git implementation code which can invoke some pretty expensive cases

Github has the blame view of files, which is much more expensive.
Yes, but what happens when someone does make fraudulent charges with it?

"The major difference between a thing that might go wrong and a thing that cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair."

I'm especially leery of anything that someone powerful and/or authoritative says can't go wrong, because when it does go wrong, that's what they'll say, again.
Many merchants take a hit to their margins, many dont. It doesnt really matter to the credit card company but what you said is useful to point out, my point was only that percent is going to the credit card company
This is something I haven't encountered before in biochemistry

"reversible covalent"

A chemical covalent bond. Maybe it means something else in this article?
1.8 TB of Police Helicopter Surveillance Footage Leaks Online
I didn’t see anybody suggesting cars and cells were alike.
Hiring SRE
Looking for Site Reliability Engineer who can join one of our clients in Seattle/Los Angeles
That's the past. wsl/wslg is a watershed moment though. Developers can use practically all the Linux tools there are while the IT department only needs to support Windows. This is a massive win for everyone involved and so I suspect this will be a default for most companies -- and business laptops are the bread and butter of Lenovo/HP/Dell. When there's no business case for upkeeping the built in GPU driver , Intel will not waste any more resources on it. There wasn't an answer on where developers should go if not native Linux (unless Mac but that's not relevant to this discussion, we are discussing PCs) now there is.

Especially now when Intel is entering the dGPU arena, there will be enormous pressure to reallocate people like you from Linux to the Windows driver team I bet.
It's great that Apple is using their power for good. Doesn't change the fact they have power over you. They decide what software you're allowed to run. You have no freedom.
> The first downside to "Anyone can build anything" is that "anyone" means anyone, and the people to whom decentralized systems are the most attractive are the ones who are banned from other systems, often for good reasons.

A similar point was made by Scott Alexander:

> HL Mencken once said that “the trouble with fighting for human freedom is that one spends most of one’s time defending scoundrels. For it is against scoundrels that oppressive laws are first aimed, and oppression must be stopped at the beginning if it is to be stopped at all.”

> There’s an unfortunate corollary to this, which is that if you try to create a libertarian paradise, you will attract three deeply virtuous people with a strong committment to the principle of universal freedom, plus millions of scoundrels. Declare that you’re going to stop holding witch hunts, and your coalition is certain to include more than its share of witches.

https://slatestarcodex.com/2015/07/22/freedom-on-the-central...
The old joke:

> git gets easier once you get the basic idea that branches are homeomorphic endofunctors mapping submanifolds of a Hilbert space.

* https://twitter.com/agnoster/status/44636629423497217
> I don't know, git doesn't have very good memory when doing rebases.

https://www.git-scm.com/book/en/v2/Git-Tools-Rerere

> Plus that it's quite hard to rewrite dates, names, or split commits into several.

Read the documentation for 'rebase' and 'cherry-pick' and 'add'.
We're not talking about government action forcing apple to sell iPads for near cost.

We're talking about whether using the governments scale to negotiate better pricing is going to put them out of business or in this arguments case whether it will reduce their spending on r&d.

The idea that it would is silly at best given how much they spend on marketing compared to r&d.

It also ignores how much the government gives them to fund new research with nothing in return, hello Moderna you Brandon loving fucks.
I find it easier to read linear history.
Same people who killed Karen Silkwood, I guess.
I think talking about "no birds" is extreme, but I do agree that covering the planet with trillions of solar panels is not environmentally friendly. The size of the footprint has to be taken into account.
What if you overdraft and then get hit with fees? Or even NSF fees?
Heck yeah. Beautiful area nestled in the Smokey mountains, first major city in the U.S. to get gigabit internet, and access to both Nashville and Atlanta with a short drive without needing to live in the awful traffic.
Nuclear is one of a number of alternatives that needs to be seriously considered but due to the long timelines and high costs of nuclear it is also one of the best stalling tactics for the fossil fuel industry seeking to extend the life of their assets. Possible increased adoption of nuclear in the future is not a reason to avoid setting sunset dates for emitting technologies now and commence transition to whatever low emission technologies are the most available and affordable right now.
on the individual level you can make mistakes. on an organizational level allowing this kind of mistakes means they discussed it and nobody found a problem with it. its a sign of disfunction.
It is more expensive mostly because the government creates economic incentives for renewables, and disencentivises nuclear. Politicians act this way because public was taught by the militant ecoactivists that nuclear energy is baaaaaaad (better use coal, right), and now vote against politicians that support it.
Because it’s file based, and that’s obviously behind a lot of the criticism coming from the author of Fossil.
It’s 2021. How I wish we had moved past pointless git bashing by now.

We get it. Many people don’t like it. They prefer to use $TOOL instead.

It’s been 16 years. Can’t we resign this to emacs vs vi category of things we’ve largely accepted and stopped arguing about yet?

I’m not mad at the article. They have preference and wrote down why they don’t use the more popular tool for when people ask. That’s fine. But I’m guessing it was posted to have the “discussion” we’re having right now (and every time got comes up). People bashing (or defending) git.

And it’s exhausting.

We’re half way to the age of vim. Can we let this one go too please?
I agree. The reason why it doesn't feel that way is because of the wealth of tutorial website on how to run git commands or the users already got used to it.

Mercurial names are much more natural but it lost the war already.

I use git every day and don't complain when using it. But when a junior is learning git, you start seeing the oddities.
That's just the thing. fork(2), like much of POSIX, was a mistake.

The proper semantics for starting a new process is something like posix_spawn or Win32 CreateProcess, i.e., you specify an executable image to start.
Create a table of inodes and link them together with some blob fields. There's your filesystem.
A fair question to ask - about any opinion piece on any topic whatosever. You think solar/wind proponents are any less likely to be corrupt/intellectually dishonest/self-serving than oil, coal, or nuclear ones? Come on