skysight-inc/HackerNews huggingface dataset:
My question/comment was not intended to spark discussion about the efficacy of ivermectin for covid-19, just confused at the classification of ivermectin as a protease inhibitor. I don't think most doctors, pharmacists, or epidemiologists would think of ivermectin as a protease inhibitor, even with a few in silica studies suggesting protease activity in certain circumstances.

There have been at least 14 RCTs, including double blinded studies. In meta-analysis, "ivermectin was not efficacious at managing COVID-19"[1]. I won't engage further in that discussion.

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500108/
I find it interesting that people who advocate we make major policy changes to avert a climate disaster refuse to entertain making minor policy changes to reduce the cost and timeline of nuclear power plant construction.

China builds literally dozens of 1GW plants simultaneously for a fraction of the price, and in a fraction of the time, using western nuclear companies.

The time and cost limitation are entirely avoidable if we make sensible policy changes.

1. We need to issue an executive order opening the Yucca Mountain nuclear waste repository. This one facility can hold ALL the nuclear waste we will make even if we move to 100% nuclear power.

2. We need to immunize nuclear plants from environmental lobby lawsuits which constantly delay projects and multiply costs.

These two changes ALONE will make nuclear plant construction attractive again in the US. Remember that large capital cost finance for profitable projects is not a problem. It's literally what Wall Street was built for. We wouldn't even need to fund the plants with gov't money.
Cash is wonderful too for tax evasion. Hence cash only businesses.
Be a Force of Nature
Green Hive provides eco-friendly customers with a resource for finding goods that they can feel good about using.
It has always lead to all kinds of problems, like computers becoming inaccessible, and corrupted data because of segfaults between disk accesses.

And also nobody ever checked the malloc result anyway. Competent programmers just ensured that the segfault wasn't a huge problem. So at the best of the days, all it did was reducing the capacity of the computer.
Could you please let me know the details of the immunotherapy your mom had? Based on my reading, i thought immunotherapy is not administered for breast cancer. Your response would help me save my mom.
Cheaper than sending troops, is all. We spend 5 billion a year on NSF in the US. Not much! Improving the scientific base of an ally could, in the end, be more effective than other aid.
Firefox reader view FTW...
Merchants may get charged a lot for credit card fees but cash handling come with significant costs too such as banks charging for deposits, having to travel to the bank, counterfeiting, security, and leakage.

This article says the cost to handle cash is 5 to 15%, more than credit cards.

https://www.palmerretailsolutions.com/blog/cash-handling
Green Hive - Be a force of nature

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You can find us at: https://www.greenhive.io
Mining for coal and uranium are two very different things
Yes, avoiding banks for international wire transfer and avoiding a banks for storing money are use cases that some people use crypto for. But these are not world changing to my original point, you could have done that with physical moving money or putting it under your bed.
It is those battery costs that make solar lose the price advantage, so yeah, it's a problem.
Unless you're building many thousands of units for a price-sensitive market, it's almost always a better use of your time to run a nice GUI on a separate PC like a Raspberry pi and do your real-time stuff on a $4 arduino or $1.50 MCU.
It's a vague question though. What kind of OS? What kind of runtime? Does "allocate" mean call malloc() and get non-null return value?
Sequence introduction: non-agent and multiagent models of mind
Oh man this brings back memories. I had a good laugh with this in the past, tried recently to find it and I couldn’t. Thanks for rescuing a classic. Another from circa the same time was “action item man”
Coal emits more radioactive particulates into the air over a wider area than a nuclear reactor generates for the same amount of power.

https://www.scientificamerican.com/article/coal-ash-is-more-...
What does that even mean? Credit card companies exist (and make money) in both common law and civil law countries.

Or you could even look within the US and examine the singular state that is a civil law jurisdiction and there is no real impact vs the other 49 states. In fact I’d wager a guess very few people even know 1 of the states is a civil law jurisdiction because it has very little impact in practice.
Imports and exports help to smooth out the load curve, but I don't down where you get that broadly France relies on German coal in the summer and winter. French net CO2 emissions remain stable and low the entire year, that's it. As far as I'm aware, heat waves have very little impact on nuclear energy production. Their impact on river temperatures is a few tenth of a degree and they can function on fairly high water temperatures (bellow 28c). I've read that over the last decade, which had several heat-waves, they accounted for an average production loss of 0.3%.

>It works so "well" that the French taxpayer will have to pay the UK so they can deliver their guaranteed energy prices the over-due and over budget reactor they desperately try to finish will generate.

Pretty much the entirety of the problems we've had with the EPR program has to do stopping building nuclear power plants for decades and losing the associated skill-set and industrial base.
I asked my teenage daughter to read this. She laughed and rolled her eyes.
Could you elaborate? What should it be used for? Graphics or other non obvious uses? Why do you think people are not using it?
It's not even that. I'm one of those people who never has their phone nearby so it would be a chore to have to get my phone out of the bedroom every time I wanted to use an appliance.
I like SQL query builders for the same reason.
The citation is infant mortality rates, and talking to all of my grandparents and their brothers and sisters and how women used to regularly have babies die or have polio or smallpox. And now it is very rare to have any of that happen.
May you remain blissfully unaware of your hypoxia
Years ago I wanted to use video game worlds to make TV shows… where you could script the characters and focus on the dialog instead of animating each frame.
(For issuer) also via overseas usage, FX fee and spread.
From TFA: "Jacopo Buongiorno, a nuclear-engineering professor at the Massachusetts Institute of Technology, has calculated that over the life cycle of power plants, which includes construction, mining, transport, operation, decommissioning and disposal of waste the greenhouse-gas emissions for nuclear power are 1/700th those of coal, 1/400th of gas, and one-fourth of solar. Nuclear also requires 1/2,000th as much land as wind and around 1/400th as much as solar. For any given power output the amount of raw material used to build a nuclear plant is a small fraction of an equivalent solar or wind farm. Although nuclear waste is obviously more difficult to dispose of, its volume is 1/10,000th that of solar and 1/500th of wind. This includes abandoned infrastructure and all the toxic substances that end up in landfills. One person’s lifetime use of nuclear power would produce about a half-ounce of waste human mortality from coal is 2,000 to 3,000 times that of nuclear, while oil claims 400 times as many lives."
Or we could just use breeder reactors.
Policy makers already have to battle deeply entrenched cultural attitudes towards nuclear technology. They can't be seen as lowering the safety measures for it too.
Global Food Prices Surge as Inflation Spreads
I didn't see the judge's response, so no. Though another commenter here mentioned it was the plaintiff that called for these people as expert witnesses (another fact I missed), which is also relevant. And I agree with the judge's take on the university's actions.

My intention with this thread wasn't to take a side or defend the university. My intention was to point out how having these specific people as expert witnesses could be seen as a conflict of interest (as compared to, say, expert witnesses that have no relation whatsoever to either party in the suit). This was in response to the people interpreting the situation strictly as "don't oppose the government". The university's actions were abhorrent, but the seed of their concern isn't necessarily invalid.
I can imagine a notebook like environment where the results of each step are put into a temp table to use in subsequent steps. Why do you think people are not using it enough? Because they don’t know SQL? Or because of tooling?
Right, it's not technically difficult to match a scaffold -- you can probably parallelize a big RDKit job, but it's nontrivial to scale to a gigascale set. And, like you mentioned, there's rule-based substructure matching (sometimes easier for those willing to venture a bit outside SMILES). Anyways, it was more a curiosity question -- thank you for the details on Lufotrelvir!
Fn+Backspace operates as forward delete and can be combined with shift, command, and option for text editing.

I’m pretty sure Option + Clicking on a dock icon will minimize it.

If you are confused with how the keyboard shortcuts work, here’s a quick guide.

The command key is the main operator for system wide shortcuts and major application shortcuts.

Command + shift is for secondary app shortcuts

Command + option is for rarely used app shortcuts

Option is for hidden options in applications and across the system. Try opening the application menu in the top bar and holding down option to see how many new shortcuts are available up there. Try option clicking or dragging things in the system to see how they react.

The control key is never used in applications and is rarely used in the system. It’s main function is in terminal applications.

Hope this helped!
I grew up in a nuclear community (Richland WA, the town where it seems like half of everyone works at Hanford). My first job (after lawn mowing) was working at Exxon Nuclear (which got bought by Siemens then sold to Framatome and then morphed into Areva). I learned to code there. My first tools were tools that helped engineers optimize nuclear fuel assembly design for efficiency.

I see these articles. I barely read them. I’m a supporter already. I get all the various details and arguments.

I left that industry though. For two reasons.

1. Regulation makes it so that what seems cool and high tech is mostly 60’s tech.

2. I got discouraged working in an industry that I knew could help the world but was so reviled and feared at large.

These days I work in ag automation. Feed the world. Robots and the cloud. That sort of thing. And yet… yesterday, some of the assembly techs were spooked by the supposed ability to have a small magnet stick to the injection site of a Moderna vaccine. I watched grown men spend multiple hours coming to the conclusion that “the magnets didn’t stick after all but something weird was going on.”

I’ve concluded that Darwin was wrong. Humanity has the ability to out wit natural selection any more.

That leads me to believe that nuclear technology (sufficiently advanced to be indiscernible from magic) has as much likelihood of mankind applying it to their benefit as they do of burning witches to save the planet.
9-foot video game joystick on record as largest
Clone an interactive AI chatbot version of yourself online – will exist forever
Currently in beta as we are completing the AI functions, you can create an interactive chatbot clone of yourself or of someone you care about. Clone a version of yourself that your great great great grandkids will be able to chat with when you're long gone. Create an account now as we are limiting signups to 1000 clones right now. Qualy is based out of Ann Arbor Michigan.
How on earth anyone would consider 'Woke' or even trying to be such to be a positive attribute in 2021 is shocking to me. Wokism and Trumpism are both ridiculous cults, where members refuse to concede basic realities in favour of some giant utopian delusion of an ideal.

They're giant diversions I think that distort our ability to just see things for what they are.

It's pretty interesting how people can be many things at the same time, so these kinds of triggering labels - and the narratives that support them in the press don't help one bit.

The recent articles by various media outlets outlining the results of the Virginia election were about 80% playing into narratives of 'each side' further ignoring the 20% of simple truths that I think were the real underlying issues. Those 'truths' just don't line up nicely with the narratives.

This problem has metastasized in the US (and rolled over into Canada) in the last 5 years, which is why 0 'aspirational locations' from the US are on my list, at least for another 5 years as things hopefully calm down.
Cheapest Black & Decker toaster oven I could find at Walmart. I think it was $29.95? Or was it $19.95? The previous one lasted about 12 years before an element went out. Probably just a broken wire, but I didn't feel like bothering with it.
Everyone involved has talked extensively over the years about what they think about the desktop UI experience there is no need to add complexity.
You can't do stats like this. Even if it seems like a small error or being overly pedantic, it doesn't work for a pretty large number of obvious and less obvious reasons.

Vaccine side effect tracking is done pretty thoroughly, so if what you see would be a real and generic phenomenon, it would have been noticed by now.
1931 “ the Electric Ship ” Ocean Liner SS Virginia GE Educational Film
The Lancet you say?

“Individuals who have had two vaccine doses can be just as infectious as those who have not been jabbed.”

https://www.bbc.com/news/health-59077036

Study: https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
“Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs.”

So, it’s not a question of which is prescribed more, it’s a question of why branded opioids are ever prescribed. We aren’t talking about a ~100 Billion dollars of accidental waste, it took a lot of work to extract that from the general public.
The afterglow as you put it was quite amazing. I don’t suffer from anxiety myself but my mood and feeling for some time after was incredible. I strongly believe that there is something there worth studying.
the UK has enough civil plutonium (extracted from waste) for several hundred years, without digging anything up
How many times was this repeated? How many trials did they have to do before they got this result? How many other objects did they try to see if its something related to the glass?
This isn't really true for Node. Node knows what package coffee is running under and relies on that for several core pieces of functionality.

Packages really shouldn't bundle their dependencies anyway.
> Also is the tap water drinkable?

I said India, didn't I? :)

Anyway, no. I don't think drinkable tap water is a developing or underdeveloped world phenomena. But I may be wrong.

> What about the air quality?

Again, it depends on which country you are comparing it with. Among Indian cities - pretty good. And I don't mean comparing with Delhi - that'd be an unfair comparison.
Anybody who is a fan of nuclear power should be against operating them in earthquake zones. Just look at how much Fukushima set back nuclear power.
Nuclear can compete purely on cost with coal. Which is fundamentally the problem. A decade ago nuclear was still legitimately the cheapest source of power but the economics have totally changed and now coal is not profitable and nuclear is likely on the way out.
Anyone have a link to the actual leaked footage?
Indian names too?
Foot is also known for her major part in the definition of the "trolley problem".

Similar dilemmas were known far earlier, but the most popular description derives from hers as does the modern study of the dilemma.
EU to adopt new cybersecurity rules for smartphones, wireless, IoT devices
I'm sorry that this is happening to you and your family. My mother was diagnosed with breast cancer in my final year of university. She had surgery and chemo and had an 80% chance of permanent remission. In my third year working as a SWE, her cancer returned. She lived another year.

A minister visited us the morning after she passed. They said some things that I needed to hear: Death is common. Grief is part of life. The pain lessens with time.

Here's my advice to you:

1. You will have inconsistent productivity and lower overall productivity. Talk openly with your manager about it. Every two weeks, have a 5-minute one-on-one meeting with them and ask for their opinion on your recent performance and their expectations. If your manager is unwilling to do this, then switch teams or jobs ASAP.

2. Talk with a trained therapist once every 1-2 weeks. They can teach you critical skills. Attend the free 10-day Goenka Vipassana meditation course. I did both of these things years later. I wish I had done them earlier. Also help your family members to get therapy and learn the skills, especially your father.

3. Dedicate some time every week to researching your mother's disease and treatment. Frankly, humanity's knowledge of cancer is still rudimentary. You can learn it. Clinicians just do what they learned in med school. You can find the researchers who specialize in your mother's particular kind of cancer, read their papers, contact them, and get her into a trial. If I had done this, my mother could have participated in one of the early trials of the TIL cancer treatment [0] and could possibly have been cured.

4. Call and visit your family members more frequently. Take short selfie videos with your mom. Also take short videos of her with people you care for. Take trips together. Send your Mom & Dad on a nice vacation. I recommend Waikiki.

[0] https://en.wikipedia.org/wiki/Tumor-infiltrating_lymphocytes
And you pay 3% on every transaction to get 1.5% back. Seems like a pretty bad deal. Or do you really think businesses just gives you 3% for free on every purchase rather than raising prices on everything to make up for that 3% loss? A raw 3% of revenue is huge, there is no way businesses can take that without raising prices as consumer sales is pretty efficient and has small margins already. So they raise prices for everyone or they raise prices for people paying for cards, but either way you are paying more than you get back for that 1.5%.
Maybe doesn't hit all of your points dead on, but Chattanooga Tennessee might be close to what you're looking for. It has the some of the fastest internet in the US, can be more politically moderate for a southern city, is not too far from Atlanta, and is really affordable for the U.S.

Not perfect but worth knowing about.
> In much the same way that a blindfolded person on a trampoline can sense if other people are on it, TRP channels help the slime mold detect faraway objects.

This is as detailed a description as the article gives in how they detect objects? This explanation does not seem very helpful since I assume the glass disks were not jumping up and down. Is there any more information available on how they sense?
Look at global prices: https://amp.dw.com/en/nuclear-climate-mycle-schneider-renewa...
From what I've read, most cost and time overruns from nuclear are due to lots of design revisions during construction to make site-specific adaptations that need to be intensively reviewed, approved, revised, over and over again. Small modular reactors are designed to address this since they're preassembled at the factory and small enough that you can easily just move the reactor to adjust for any site adaptations. Unfortunately still years away from approval.
how are you getting that coal is not profitable? Demand for coal is at an all time high. Check out coal prices.

https://tradingeconomics.com/commodity/coal

We are also producing more coal than ever before (modulo the dip during covid lockdowns), and coal use is projected to increase:

"Global coal production is expected to grow at a compound annual growth rate (CAGR) of 2.3% between 2021 and 2025 to reach 8.8 billion t in 2025. While thermal coal production is expected to have a relatively marginal 2% CAGR to reach 7549.6 million t, metallurgical coal is forecast to register stronger growth of 4.2% per year, to reach 1216.9 million t in 2025."[1]

[1]https://www.world-energy.org/article/17139.html
You are creating an account now so when we launch our beta in the next few weeks your account will be ready to go. Limited to 1000 clones only.
how can you do it for free? and last forever?
> Electricity is only 28% of global emissions.

Then how do you intend to decarbonize other energy uses without electricity? Want to replace gas furnaces with heat pumps? electricity. Produce hydrogen for shipping or CO2 free steel? Electricity. Charge everyones car battery? Electricity. So on, right?

> This isn't hard math.

Or 4 billion years:

https://whatisnuclear.com/blog/2020-10-28-nuclear-energy-is-...
Nuclear is socially and therefore politically non-viable because

(1) When nuclear accidents happen, they suddenly overturn the lives of a LOT of commoners all at once as opposed to slow and creeping and often "statistically determined" impact of other energy tech

(2) technocrats have consistently failed to demonstrate the ability to create organisations that over the long term prioritize safety and the ability to prevent accidents over all else (maybe with the exception of US Naval Reactors org - but who knows given the secracy)

People instinctively get this now. Fukushima was especially a bad shakeup because "if even the Japanese can't do safety right, why would we trust the dumb nerds we went to school with to be able to do so".

We should move on and focus on other clean energy tech, scaling up storage tech and stop wasting time and energy debating fission. And Maybe figure out a rebranding for "nuclear fusion" whenever it works (hopefully within my lifetime) assuming it's safety profile is better.
Oh, they've not declared it as a lease violation, they've just asked me to do it this way and I've compiled, despite being annoyed by it. I haven't checked local laws (MA), but I've tried to be a good tenant.

Also, no, my bank will not do this for me. My landlord actually is overseas (permanently), so mailing a check is not feasible.
Maybe a system call that checks whether writing to a page would result in a fault? What if we had memory file descriptors for pages? We'd be able to use them with epoll and io_uring to asynchronously check whether it's safe to write to the pages they represent.