skysight-inc/HackerNews huggingface dataset:
Is regulatory capture not a thing anymore? Why do you trust this company?

https://corporatewatch.org/pfizer-six-scandals-to-remember/

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.
It’s not really like a vaccine. A vaccine is almost more abstract. You’re not sick, and to continue not being sick, take these shots.

With this treatment, you ARE sick. To become well, take these pills.
A very handy tool indeed!
Maybe its just correlation/coincidence but I wonder why companies associated with Jeff Bezos have such a toxic culture ?!

I know Rivian is only funded by Amazon, not run by them.
Are there any authorized or approved drugs that are taken over a short-term (say less than a month) that have been shown to cause long-term death?
Cisco patches critical bug trio in Policy Suite and ONT networking devices
It would be a trade-off I'd consider if alternatives didn't exist, but they do. Someone down-thread mentioned Cloudflare Workers, which have a sensible pricing model. These days I use Google Cloud Run, which gives me everything I wanted from Lambda but has model where you pay by CPU time rather than invocation time, and allows a CPU to handle multiple requests.
True, OTOH unless the side effects are worse than covid, this is absolutely game changing
Leipzig has a nice zoo, and it’s one of the rare zoos that has Bonobos. They are amazing to watch: mothers happily walking upright holding their baby, lots of playing, just generally enjoying themselves. To me they seem much more human than chimpanzees do (they are equally distant in evolutionary terms).
Yeah, though in this case, whitelisting opcodes probably would have at least avoided qx and ``(both exec()). Avoiding the eval() altogether would be the right path, of course.
They announce (known) breaking changes that may require manual intervention. Meanwhile, when my ubuntu upgrade breaks something there is never any release notes or documentation to help me fix it. After my previous ubuntu upgrade at work, the screen locker is segfaulting instead of locking my screen, and clicking links inside the Slack crashes slack...
> for cost of increased power consumption

Read the "Per Watt Results" chart on page 12: https://www.phoronix.com/scan.php?page=article&item=intel-12...

The i5-12600K leads performance-per-watt results in most tests.

They include power results for some tests, where you can even see the i5-12600K consuming less power while outperforming most of the AMD parts: https://www.phoronix.com/scan.php?page=article&item=intel-12... This doesn't hold for every test, but the power consumption issue has been greatly exaggerated.

If power consumption is a concern, do not buy the i9-12900K. It's a no-compromise chip that disregards power efficiency for the sake of peak performance. Buy the i5-12600K, which is actually decently efficient.
You've already copypasta'ed me this elsewhere.
What an amazing tool! Thanks for posting!
It’s not. The article simply assumes that actions that the ad networks don’t like are somehow “illicit”, without providing a rationale.
From my experience with cancer in my family, I think the number one thing I would recommend is that you should remember to keep treating your mother as the normal person she is, and not as a cancer patient.

A lot of her life is going to be cancer this, cancer that, these drugs and those drugs, doctors A, B, C, and D, and always an another upcoming appointment on the calendar.

It's tiring for her and it's hard to maintain ones dignity when everyone around you is being constantly sympathetic over a protracted period of time. It's a difficult idea to convey; you don't want to ignore her struggle and illness. Just don't let the cancer subconsciously become your definition of her.

As far as coping, it's going to get worse before it gets better. Hearing the news of cancer is like grief, except worse because you have the legitimate hope that things might get better.
I see a lot of python and js/node as basis of comparison against Haskell which seems really odd.

I would be comparing Haskell more to Scala/Elixir/etc if you're trying to make an argument for Haskell.
FamilyMart trials AI robot for restocking convenience store drinks
haha it wouldn't be an uncommon expression in informal English (depending on the region of the USA) but to see it in print like that is unusual.
Your intuitions about airborne transmission are based on the idea of viruses being carried in relatively huge droplets of water, which due to their size and weight would rapidly fall to the ground. Hence constantly wiping surfaces clean, sneezing into the nook of your arm, mask mandates and lockdowns reducing transmission, etc.

This theory is inconsistent with the evidence: mask mandates have no effect on case numbers and nor did lockdowns. Whether you like this or not is irrelevant - the data is final. Therefore the droplet theory is wrong, and by extension theories based on it are also wrong.

There is an alternative theory of how SARS-CoV-2 spreads through the air: that the viruses can exist in fine aerosols that can be suspended in the air for relatively long periods. This theory is consistent with the evidence actually available:

1. It's consistent with islands that closed their borders early being able to keep the virus out, but nowhere else.

2. It's consistent with mask wearing having no effect, because masks aren't airtight. You still need to breathe in the surrounding air and the holes in masks are much too large to stop a very fine suspended aerosol. Additionally it wouldn't matter even if they are airtight and very good filters because there's evidence the virus can enter via the eyeballs too.

3. It's consistent with lockdowns having no effect. Even in "lockdown" lots of people still need to be in areas recently vacated by other people, like shops, factories, anything to do with the supply chain.

4. It's consistent with the apparent lack of infections outside. Where the wind blows, aerosols emitted by an infected person are rapidly dispersed in the air.

5. It's consistent with the failure of measures like handwashing to keep the virus out of care homes.

It's also consistent with SARS-CoV-1, in which an outbreak was investigated and the conclusion was it circulated through an apartment block via air in drainpipes:

https://www.washingtonpost.com/archive/politics/2003/04/18/i...

That isn't possible with the droplet theory, but is perfectly possible with aerosol theory.

The fact that "actual scientists" doing "real research" show that masks work is actually evidence that their research is garbage and they aren't "actual scientists", at least not if we define scientists as people who successfully apply the scientific method to understand reality. If they worked then you'd be able to consistently see the impact in case numbers, but that's simply impossible.

If you read any of their studies you'll soon be struck by how universally poor the quality of COVID research actually is. The scientific method as normally meant has more or less gone AWOL and what's left behind is a bunch of people who very much have an agenda desperately trying to justify why their previous advice wasn't wrong. I really couldn't care less what "actual scientists" think at this point. If they want to be taken seriously they need to provide evidence that's strongly convincing on its own merits, because their institutional credibility has long since turned to dust.
It's silly to normalize the notion that people should have upgraded their devices after just 20 months, especially when that span of time is linked to a supply chain shortage. Consuming new computers all the time wasn't sustainable even before all of this started. Maybe Microsoft should upgrade it's common sense.
Please don't misrepresent VAERS.

"Due to the program's open and accessible design and its allowance of unverified reports, incomplete VAERS data is often used in false claims regarding vaccine safety."

https://en.wikipedia.org/wiki/Vaccine_Adverse_Event_Reportin...

VAERS is an unvetted database of adverse events that occur some time after a vaccine has been given. It does not mean that there is a causal link.

"CDC cautions that it is generally not possible to find out from VAERS data if a vaccine caused the adverse event, or how common the event might be.[5]"

Particularly, in the current pandemic, we vaccinated a LOT of sick and elderly patients, and we vaccinated them first, in almost unprecedented numbers. So VAERS will have a LOT of "adverse events", simply because the sick and elderly have a lot of these adverse events, vaccine or not.
Async await at the language level isn't a scam. Its an attempt to build an alternative to statemachines( large switch statements) and nested callbacks.

It just so happened that we were trying to break 100k connections on a single machine at the same time, which requires you to avoid thread switching. Something which an async executor is also doing.

Those two goals got combined into to "the great next thing that's better in every way" when in reality, 99% will never hit that bottleneck, and the people who write good async code could write it in either of the two other forms as well.
https://web.archive.org/web/20211105044719/https://www.nytim...
More Than 100M Not in Labor Force for 14th Straight Month
Every developer that does not know about it will eventually come to discover Amdahl's Law on their own.
Your counter-points to (1) don't seem any different to the monolith vs. microservice debate. Much of your critiques are not so much problems as they are trade-offs. And they've been talked about ad nauseam.
> Ventavia executive identified three site staff members with whom to “Go over e-diary issue/falsifying data, etc.” One of them was “verbally counseled for changing data and not noting late entry,” a note indicates.

> At several points during the late September meeting Jackson and the Ventavia executives discussed the possibility of the FDA showing up for an inspection (box 1). “We’re going to get some kind of letter of information at least, when the FDA gets here... know it,” an executive stated.
Never use random module for generating passwords
I wonder if this isn't to document the requirement for H-1B visas that they tried to find a local candidate but were unable.

https://nearshoreamericas.com/us-makes-h1b-visa-harder-obtai...

Wouldn't it be hysterical if the hiring process all these companies are cargo-culting was actually designed to not hire people so H-1Bs could be used.
Thanks! And even more interesting, there is Varia Vision:
https://www.garmin.com/de-DE/p/530536

How I could missed that. It not a glass but an clip to add.
> May be entirely mythical, and certainly doesn't leave us with any useful evidence to evaluate from a psychotherapy standpoint.

I know quite a bit about psychotherapy (Schema Therapy, CBT, DBT, Transactional Analysis) and I see very little use of such evolutionary explanations, even if correct to any form of therapy.

If Stockholm syndrome was real and if women were evolutionary inclined to physiologically respond to their captors sexual advances and later "infatuate" (so as not to suffer violence and that the children survive), how could that be useful in any way to psychotherapy or law or any other area of human life?
You might want to use a different analogy:
https://en.wikipedia.org/wiki/Fire_sprinkler_system
The first line treatment for strep throat is penicillin or amoxicillin. Z-pack (Azithromycin) would typically only be used in case of a penicillin allergy, or maybe resistant bacteria.

https://www.goodrx.com/blog/z-packs-still-good-for-infection...
The other fun development is take-home Data Science problems, where you have to spend a weekend, you're never quite sure if your results are good enough (you can always improve a model), and then they want the regular panel of interviews on top of that as well.
Tyler Cowen: The Coming Shock That Will Transform the U.S. Economy
Assuming this is your motive you wouldn't put a token diversity hire in charge of the thing that drives your revenue. You would put them in a bullshit job that had no impact on your top or bottom lines.
When both the risks and vaccination rates are significantly different across demographic groups statistics for the whole population are often nearly useless due to Simpson's paradox.

Depending on how we define severe COVID you link is showing between 36% and 44% of the severe COVID patients at the hospital are vaccinated.

That's similar to what they have seen in Israel. As of about a month ago they were seeing about 60% of their severe cases were in vaccinated people.

Sounds pretty bad for vaccines, right? It does until you remember Simpson's paradox and take a finer look at the data [1]. It turns out that the Israel data showed in each age group efficacy against severe COVID ranging from 81.1% to 100%, with above 92% in all the 10 year age groups under 60 and still above 88% is the 10 years groups through 80.

It is very likely a similar thing is going on at the hospital whose data you linked to. That's been the case for every place I've come across in the US that published breakdowns of the stats by age group.

[1] https://www.covid-datascience.com/post/israeli-data-how-can-...
I did an internship at IBM (~15 years ago) and they said that not only does IBM have the most patents, it tries to have the most patents awarded every year. You could just send half arsed ideas to a team of lawyers and they would write it up into a proper patent.

Getting patents in your name was a big part of moving up the internal engineering ladder.
Except that this pill won't be given to people unless they're already sick with COVID. Not that this will stop the tinfoil hat brigade, but it's going to be much less controversial than universal vaccine mandates.
I think the shortest interview I ever had was:

Interviewer: Hi there. Wait. I was just called for an emergency. I am really sorry, but I have to go.
Me: Oh dear. I hope everything is okay.
Interviewer: Thanks. Again, sorry. Talk soon. Bye.

The next day by e-mail:

Interviewer: When can you start?

That lead to a great working relationship. The current age is indeed ridiculous.
I had a healthy and stable home life, but also parents who pretty much left me to my own devices when it came to school work. In elementary school, I mostly did my homework and never, ever studied for a test. In high school, I did about 50% of my homework and probably studied for a grand total of 3-4 tests over that four years. All the while, I aced tests with nearly straight As.

In school (elementary school especially), I'd finish tests and other work well before other students, would be bored as they asked questions with "easy" answers, etc.

When I got to college, I had zero healthy study habits, and got a good six months of getting my ass kicked until I sorted things out. It wasn't until then that I actually felt challenged and engaged. Until then, I expected to get As and didn't have to work for it. Once in college, where I was challenged, EARNING As was so satisfying. I still remember the feeling of accomplishment of getting As in two chemistry classes, which was a subject I didn't like and I had to work HARD for those grades.
I only use macOS for work now because they have become too expensive to keep one just for personal use. The new M1 Air is not that expensive though, but it's still 3 times the price of a decent AMD based laptop.
Agreed. The reports that VAERS provides can hint at rare adverse outcomes for vaccines, but it simply doesn't hold any significance compared to clinical trials. Comparing them is just outright false equivalence.
Wait a minute. I don’t see any political position in the comment you’re replying to. I don’t even see a hint of one. I can’t even figure out what political position on what topic would be likely.
Whilst I don't buy the malice (big pharma deliberately not curing things they could) argument, there's plenty of things they don't do 'cause they don't think they'll make a profit on them.

Novel drug research is extremely expensive and time consuming, logically speaking a for-profit pharma company will assign its resources to the research which is most likely to make a profit.

As a result rare conditions will not attract the research necessary to create drugs to treat them. To give you a concrete example, AFAIK there was never a vaccine for MERS which is a coronovirus which preceded COVID-19.
> even for the compiler are no "safe bounds" with volatiles unless all the operations are volatile

That's exactly what I said right? But good to know that volatile won't emit fences.
My experience is that that option becomes re-enabled pretty often, even when I'm logged in and on the same device. It should be an account-wide option that's preserved and respected across all devices.
This is an early version of the project, so this is most likely not directed at end users. Why would you even address end users at this point? Nobody will use it for a long time anyway, so in my opinion is a great move to address potential contributors in the design doc.
Okay, a little further digging into their claims and successes reveals what I think Sam's point of "they built a generator that produces electricity" means.

As some one else mentions, part of Helion's novelty is that they don't use heat to produce the electricity (through steam and traditional generators). They use the Faraday effect on the (pulsed) magnets.

This is (I think) unique to their approach. Therefore, if they actually have "built a generator that produces electricity", it may prove that part of their concept.

Then all they need to do is get the fusion part working for longer than 1ms.
> Ventavia

> Ventavia

You're aware that Pfizer isn't spelled V-E-N-T-A-V-I-A, yes?
Ha ha, funny satire.

Wait, reading this again... you’re serious?

So do you have an actual time machine and can go to the future and know side effects a year from now?

The long term effects are unknowable. This mRNA technology is brand new so please don’t compare that to a traditional vaccine.
The whole idea of OOP is you have mutable data coupled with the methods that mutate it.
Haskell is really an underrated super power for building backends and web apps. The ecosystem has improved quite a lot over the recent years. With the Haskell Language Server and the Haskell Plugin for VS Code there's now really nice editor support. The language itself is also improving at a good pace, e.g. the latest release of GHC (The haskell compiler) added support for dot-notation, so you can now write `someValue.someField` as you might know from other languages.

If you're curious about giving it a try and are doing web dev, check out IHP, haskell's largest web framework: https://ihp.digitallyinduced.com/ (Disclaimer: I'm founder of the company that makes IHP)
I do not understand your comment. Could you expand on why Intel would stop developing Linux drivers for their iGPU?

My understanding is that Intel has very strong Linux drivers for all their hardware. For their entry in the discrete GPU market they will likely provide good Linux drivers to distance themselves from Nvidia.
But what do they do with them all? Seemingly not much...
The points listed cannot "as easily apply to Java", and, really, not to C# either. You really need a functional language to meet the "requirements" listed, which are -from TFA, almost at the top-:

> Why? Three reasons:
> Functions in the mathematical sense.
>
> No statements, no instructions, just expressions that don’t ever mutate. Everything returns something. You don’t mutate by default.
> Type-driven programming.
>
> Start thinking generally, in broad concepts, about what kinds of info you’re dealing with – the inputs, the outputs, the steps – and then work down to implementation. Start in the center w/ a little implementation and work your way out.
Haskell makes illegal states unrepresentable.
>
> You can't do the wrong thing with this data because this data can’t handle that, it just doesn’t accept that kind of thing.
This is one of the most persistent pieces of misinformation I've seen, especially in the face of clear data.

The reduction in transmission rate for the vaccinated is 89%. Even for someone with a breakthrough infection of the more contagious Delta variant being vaccinated means a 63% reduction.

https://www.newscientist.com/article/2294250-how-much-less-l...
For us, I think the sweet spot is a little riskier than renewable energy ETF's but a lot less risky than a fusion moonshot.

If electricity gets just a little cheaper (and it's fairly obvious that it will), then Power-to-Gas technology becomes viable, and could displace fossil fuels quite rapidly.

I'm looking into it. Email in profile if you're interested.
Diseases like COVID are probably some of the easier ones to cure. It’s a foreign body that is tangible. We deeply understand how the virus replicates and how it works. We know which proteins and nucleosides to target. We don’t have that luxury for diseases like cancer, autoimmune diseases, and the like.
I really hope GIL goes away so that async tasks can be dispatched in many threads, like done in Go or Rust. Something like one thread per core, plus work stealing to distribute tasks in threads.

Dealing with threads directly is significantly worse. It's harder to do task cancellation, harder to do timeouts, you often need to reach for locks for the simplest things.
I couldn't finish anything past the first paragraph because the background made me nauseous
> we are going to talk about what diversity, inclusion, and belonging mean to you.

Genuinely curious. Do others see this as a red flag? That would be an immediate deal breaker to me, as it suggests the company is dominated by political obsessions. I know this sort of this has become more common, but having it in the hiring pipeline seems quite extreme.
I don't know enough about the difference between how viral RNA polymerase and human RNA polymerase function, but my hunch is the nucleotide substitution might not apply to us. This could be wrong.