skysight-inc/HackerNews huggingface dataset:
Others have said this using different words, but evolution relies on the preservation of low-cost mutations. It took many mutations to get from photoreceptors to the mammalian eyeball.

If the cost is small enough that other factors dominate your ability to procreate, it will spread to all of your descendants. If other genes in your genome make you reproductively successful, that gene edit will spread and spread.

It’s a good thing these cheap changes are preserved, or viruses and bacteria would have wiped out all multicellular life early on by practicing patience. We all have genes that make us less susceptible to some pathogens than others and if a bad enough variant comes around, suddenly we are over represented in the next generation. If the hits keep coming eventually our family reunion may be the only one being held.
Well this one is made by Rust devs now, those folks certainly have a lot of experience in "transitioning".
Twitter in Plain English (2008)
Also not leveraging purchases would be considered financial management malpractice unfortunately and likely result in a hostile takeover of the company or at the least a change in management. This is a major reason companies get into trouble with debt during times of increased interest rates; proper unwinding of debt and sale of assets near the top is key when playing with leverage.
Wow. This is eye-opening.

I'm surprised this isn't at the top.

Is paper better? Why do hospitals use electronic records then?
Scamwicks and Stop Cascades
I think objectified is more likely the feeling than shame. I can think of no more certain way to let someone know they are being hired from the neck down than to offer them a job after 5-10 minutes.
I'm a technical person and I have no idea what your post means... and I also need to figure this out and explain it to the rest of my (extended) family.

Google Accounts are the new printers, familial-y speaking.
Nice! A great idea to remain connected with your teammates when working from home!
US sanctions 4 companies selling hacking tools, including NSO Group and Candiru
low tech, but with google account?
> For small businesses to pay more, they have to raise prices,

And for them to hire employees who can afford the skyrocketing housing costs, they would have to pay more. Possibly much more.

It's puzzling that many small biz owners don't seem to grasp this bit of economics. At least they give no sign.

I know they can't fix this bit of reality, but they seem clueless about it.
fame
If you have been diagnosed with narcolepsy your organisation should probably grant you a formal accommodation to cope with your disability.
Well actual numbers will be released tomorrow when embargo ends.
There's also Skybison and Cinder, but I'm biased since I worked on both.
Smarkets | Full Time | HYBRID
(London, UK; also Downtown LA, California)

We're a modern betting exchange, going technology first to enable proper price competition in a field of fat commissions. Join a small and agile team in our beautiful office in St. Katharine Docks. If our US location tickles your fancy, you get to help a sunny satellite office too.

Smarkets develops a reliable, low-latency, highly concurrent betting exchange based on trading exchange designs. We're also building a fast, modern web interface to allow for a smoother experience. Servicing our users is top priority.

The Smarkets platform is written predominantly in Python, C++ (replacing still present Erlang) and Javascript for React & React-Native, relying heavily on asynchronous programming techniques. The tech stack sports Kafka, Postgres and Kubernetes. We use REST where we can, and gRPC where we can't.

Life at Smarkets circles around people, version control, configuration management and automation. We can - and do - deploy to production several times a day. Production environment is in AWS. In fact, Smarkets was the first gambling operator under the Maltese regulator to get permission to run everything in the cloud. We push the envelope where needed and educate auditors when necessary.

We are looking for engineering talent all across the board: frontend and mobile, infrastructure, data science, trading engine, security - and of course generalists, those yet to find their calling.

If you like the idea of flat structure and practical engineering approach, see our jobs at https://smarkets.com/careers .
For those interested, there is a web simulation that you can try as well: https://stopcascade.netlify.app/
Apparently the safeguards consist of using a non-SMS method of 2FA. Maybe just do that in the other case too.
I did this 20 years ago and ran the server for about 10 years. I down-scaled the server hardware when I transitioned to solar, but soon discovered that the low-power server just could not keep up with the demand. I upgraded to something in the middle that could handle a decent number of web users while still not using all the solar. I had 1280W of panels (16x80), a 1500W inverter, and three deep-cycle 12V 50AH batteries.

The remnants of the system can still be seen here: http://jsl.com/solar
There are multiple types of dementia, a woman with known heart disease might have vascular dementia (dementia related to decreased blood flow to the brain). This article is really about alzheimers (although that's not clear from the title, it should probably say "(maybe) don't get alzheimers").
you should try virtual happy hours with the team. once every couple weeks, generally just an hour or just long enough to finish a beer. If the group is kept small it can be a pretty good team builder as long as an effort is made to include everyone in the conversation. Felt forced in the beginning but generally most teams have at least one person that can get and keep the chat going. Still keep it going now with people I used to work with even though we all went our separate ways.
Sorry, haven’t read these yet, but any antibodies? Like any immune response makes you duller and at greater risk? Eek.
Pyrite then?
Thanks! I think it spent around $1100 in total, but then I paid for fast shipment and ordered quite a lot of parts that I ended up not using. You can probably build it for $600-$1500, depending on where you source the parts, what quality you buy, speed of delivery etc.
That’s right, it is tongue-in-cheek, and a stereotypical way of doing so.
It would be interesting to set up a server/PC that throttled The CPUs/GPUs by power use rather than thermal readings. It’s analogous to the burst credit system used on some EC2 instances, but it would be a cool kernel or hardware feature for devices that are completely solar powered.
Is this the standard answer now every time someone complains of beating treated like shit? "I was walking down the street in broad daylight and someone beat me and threw me in the gutter!"

"Nobody is obligated to teach you self-defense."

"I tried to stop while driving but my breaks failed and I crashed into a house!"

"Nobody is obligated to teach you proper car maintenance."

"My wife's surgeon lied about his qualifications and now she's dead!"

"Nobody is obligated to teach you how to spot a quack."

IT'S NOT OUR OBLIGATION EITHER. It's Google's, to make products that don't abuse and exploit their users. Stop this bizarre gaslighting tactic. 2FA is a shitty scam system that increases complexity and failure rates, radically decreases privacy, and DOESN'T increase security because the vast majority of users will just use SMS, which is easily hacked.
They believe that the "causality" of weight gain is reversed as opposed to EBM - it's not that eating more calories causes weight gain, it's that your body choosing to store more fat (because of higher carb intake) causes you to eat more calories.

I disagree with their ideas, but they do offer very specific differences from the EBM model, both as a tool for understanding obesity and as a tool for transforming public health.

E.g. even in their abstract:

> According to a commonly held view, the obesity pandemic is caused
by overconsumption of modern, highly palatable, energy-dense
processed foods, exacerbated by a sedentary lifestyle. However, obesity rates remain at historic highs, despite a persistent focus on eating less and moving more, as guided by the energy balance model
(EBM).

They're directly challenging the "orthodox" view that we need to get people to eat less and move more.

But that view works! It's not the end of the discussion, because people overeat for many reasons, and in my view high palatability of food and having more wealth are the main culprits. But they clearly disagree, since they devote sections of their article to addressing exactly these ideas and why they're wrong.

Btw, for the record, all these researchers are way more knowledgeable than I am about all of this - I have no education in nutrition at all. But I have pretty solid evidence that they're wrong - lots of other smart people say they're wrong, there's lots of direct evidence that they're wrong (studies in humans), I personally lost a bunch of weight by counting calories and restricting the amounts that I ate, etc.
Would you be bothered if folks built their own solar farm to power crypto mining on their own independent grid?
Luckily, tracking your physical keyboard in VR has already been a thing for a while, and it has both quite solid third-party[0] and first-party implementations[1] by now.

To clarify, when I say "tracking", I don't mean just being able to use your keyboard in VR. I mean being able to actually see your keyboard in VR, along with being able to see keycaps on the virtual representation of your keyboard.

0. https://uploadvr.com/immersed-real-keyboard-support/

1. https://www.cnet.com/tech/gaming/typing-in-vr-how-to-connect...
In economics, the Jevons paradox (/ˈdʒɛvənz/; sometimes Jevons' effect) occurs when technological progress or government policy increases the efficiency with which a resource is used (reducing the amount necessary for any one use), but the rate of consumption of that resource rises due to increasing demand.[1] The Jevons paradox is perhaps the most widely known paradox in environmental economics.[2] However, governments and environmentalists generally assume that efficiency gains will lower resource consumption, ignoring the possibility of the paradox arising.[3]

https://en.wikipedia.org/wiki/Jevons_paradox
Getting offended at every low-ball offer seems like a difficult way to live life. It's not like showing anger is going to get you a better offer or better working conditions. That's the point at which you smile, politely decline the offer, and later on reflect on which red flags you missed when you did your research on the company before and during the interview.
They are not conspiring. It just makes a lot of sense to keep operating under-staffed (your labor costs are now a fraction of what they were) as long as the revenue keeps rolling in, using "labor shortage" as an excuse to customers for why quality has gone down, and to employees for why they need to work overtime. A lot of it is also PPP loan fraud - PPP loan forgiveness terms let you weasel out of actually re-hiring staff as long as you make and document some effort at trying to hire (https://quickbooks.intuit.com/r/coronavirus/rules-for-rehiri... I assume the rules are similar for second draw). Also, why would you hire someone at what you believe is an "unreasonably" high wage right now, given that you believe that wages will go back down in the near future? If I was running a small business in the US with employees right now, I would be doing the same, no conspiracy necessary.
If deficiency to tensors and differential forms is a reason not to be taught, then why do we learn about vector notation?

Oh right, because it's a natural language for talking about geometry and mechanics, by far the most common and important type of reasoning that the average student will need to do. And geometric algebra is demonstrably superior for that domain. So your comment is pointless.
Please avoid making bad faith interpretations. I'm reading that comment as this: surely you can acknowledge that sysvinit is not a good solution for many people? And just for the purpose of adding some structure around sysvinit, systemd does an adequate job? And if you have an advanced use case that requires a very specialized init system, I hope you can understand how that is uncommon?
You might also want to look at the mostly printed CNC, which uses standard conduit/pipe for the frame.

https://docs.v1engineering.com/mpcnc/intro/
As acquisitions go, this has probably been one of the best executed ones in recent history. MS deserves a lot of credit for having managed that very well. And I'm sure a lot of that is also due to Nat's management.
I don't have a problem allowing an unlimited number of H1-B/O-2. What I have a problem with is their salary is FAR too low.

To bring someone in from a foreign market they should be earning the top 10% of income for their field. The fact that they are synonymous with "cheap" is a major issue with the way the system works.

The current H1-B minimum salary is $60k That's FAR too low. They should be earning at least double that number so as not to artificially depress wages in the US.

It creates perverse incentives for companies to "look" but not find employees (unless they are willing to take a sub H1-B wage).

But further, H1-B employees are often in a terrible power dynamic. Being fired from their job often means being deported.
I'm sorry but the thought of ships using docker is really funny to me
LibrePCB 0.1.6 Released
That was not was I was trying to say: Overall, we _should_ try to shift workload towards times where the average carbon intensity is low. Statements like "energy is usually cleaner at 1pm than at 7pm because of solar power" absolutely hold true. It's just that from the perspective of shifting a single compute job, marginal carbon intensity could be a better metric.

However, imho that's super speculative: The question which power plant will produce the "next" kWh of energy is very complex. It depends on a variety of factors like energy prices, weather (forecasts), expected future demand, contracts between energy providers and grid operators, etc. Additionally, one also needs information for all neighboring regions, as fluctuations in supply and demand are often regulated via cross-regional flows. That means, also in the future we will most likely not have a perfect methodology for estimating marginal carbon intensity.

Regarding the hardware: No, we did not look into this in this paper. The goal should not be to buy more hardware and data centers are barely ever used at full capacity. Also flexible workloads are not only important for carbon footprint (think of Spot VMs/Instances). However, real life resource and business constrains will definitely lessen the potential of savings.
Am I understanding this correctly: you can't sign up with Authy for Google Accounts if you don't have a mobile device to authenticate with first..?
My mind goes to the healthcare staff who still have to report to their facility for 7:30 in the morning no matter the weather.

There has been a lot of social change since the 1930s. Back then, nurses were seen as subservient and likely lived in residence attached to a hospital. Reporting for duty was not an issue on bad weather days.

No one will live apart from their family in this day and age without appropriate compensation, like the way nurses do working for FHNIB nursing stations up north.
It’s that way because Congress makes it that way. That’s how they decided to run it and they are the only people able to change it.
Function follows constraints.
Yeah it can! Ivan Miranda, the guy who has created the blueprints actually updated his machine with aluminium parts, milled on the CNC-machine. That might be something I'll do in the future!
I still have music CDs from 1985 and CD-R from 1995 in perfect condition. None of them have gone bad.
Not so. Behind the two ROM cartridge slots there were three slots for RAM expansion, each being 16KB.
So that's an x64 toolchain linking to various libc's, roughly an x64-executable linker benchmark then, meh.
GrapheneOS runs all open source software (no closed source Google code), doesn't phone home to Google, doesn't allow for targeted updates based on IMEI, has strong app memory isolation, and isn't vulnerable to run of the mill NSO zero days. Buy a Mint Mobile SIM card with cash and boom, anonymous phone not tied to your name.
A close friend of mine left her company after a such a toxic manager was given only a warning after repeatedly verbally abusing her and her colleagues. The HR department called that warning an "appropriate action" and closed the investigation. It highly depends how willing are your boss's managers to take action, but it is likely that they know and that they do not care. I don't have an advice besides that you should check if you have your six months of salaries fund to get out if you report him and nothing follows.
Which isn’t that hard for a switch mode converter. Those are usually 85% or more IIRC.
Fully Managed RStudio on Amazon SageMaker
I would shrink them out of existence - I hate the damn things :)
Can you name something that is not "unlimited"?

I don't have a limit, I never hit the cap. By that logic nothing is unlimited (texts, calls, data, etc), but realistically it doesn't matter because I don't use it much. I don't care to test it, I use it sparingly and never had a issue with limits.
You also need a device for logging into a Google Account at all. These can be the same device.
How did you regain access in the end? That's the only worry I have with relying on Google services so much...
you can register domain on your own name.
Multi-level clicking… is that what they used to call force touch? If so, it’s interesting you say that, because I think it should be consigned to the fires of hell. My failure rate (at clicking with the correct force) is around 20-40%. My less tech-savvy relatives always seem to find their Apple trackpads confusing and unintuitive, they never understand why they have to click several times to get it to do what they want, and they are usually very pleased to discover this complication can be disabled. I also hate tap-to-click, but relatives mostly seem to like it and mostly understand it.
The resilience is because (1) those titles ran on systems with no MMUs; (2) there was no heap and no malloc implementation, therefore no way to get use-after-free. None of these points apply to modern systems, including consoles.
People talk about inflammation vs metabolism. They are linked. Inflammatory signals can turn cellular metabolism up or down.

African sleeping sickness is an infection that results in a person going into a kind of coma. The parasite constantly changes its molecular interface with the host which is supposed to confuse the hosts immune system. This places a huge burden on the immune system and results in the host becoming hungry all the time, despite already being full. These patients will stuff themselves while growing progressively more tired. And eventually they fall asleep permanently. Inflammatory signals slow metabolism or something to that effect and this change in metabolism causes the body to feel as though it’s starved of energy and so the patients feel hunger. Inflammation and metabolism are linked.

A man with schizophrenia was cured after a bone marrow transplant. The New York Times wrote about it recently. Symptoms of age including cognitive decline have been reversed in mice and humans through blood dilution/ blood transfusion probably due to reduction in the concentration of inflammatory molecules in the blood that are produced by ones own body. Inflammation/metabolism is the biggest medical revolution on the horizon. Especially since COVID has made it a grant-worthy topic now and doctors can’t deny that chronic fatigue syndrome is real anymore. It’s funny how all those people who insisted that CFS wasn’t real are now nowhere to be found to answer for their mistake.
Because you are supposed to want to use Apple Pay! :D
Right. I don't immediately see how either of those would work for uncountable infinite sets, but it may be possible.

Clearly some other limitations are required to make "dimensions" a useful metric in this context.
If the skills and abilities listed on your resume are what I'm looking for, you seem like a rational person who told the truth on your resume in the brief interview, and your references are clean, why would I waste anyone's time by stretching the process out?

I thought HN hated convoluted hiring processes for the sake of making them convoluted?
I remember a very similar research project from the 90s. A 3D Holographic cube that was supposed to have a, at the time, insane density.

https://en.wikipedia.org/wiki/Holographic_Data_Storage_Syste...
I'm not sure I understand your argument, but if large portions of the genome have no effect on phenotype, then perhaps we can both agree that those regions would not be under selection. Pressure on the phenotype cannot directly alter the genotype (no Lamarkism), but it could select for or against the fraction of the population with a particular genotype. But only if the genotype produces a phenotype.
I'm baffled by reports of misclicks and whatnot from Mac laptops. I assumed, before clicking, that the complaint was about PC hardware, because I've YET to use a Windows laptop that doesn't suffer from this.
I run my static blog on a Raspberry Pi3B+ Powered by solar [0] and it doesn’t even flinch when it is hit by hacker news.

It idles at around 3.1 watts and that power usage includes a step down converter from 12 volt to 5 volt.

A bunch of lead acid batteries of various capacities provide backup. Lead acid is a terrible choice because charge times are long, but it is sufficient for now.

Just see it as performance art.

[0]: https://louwrentius.com/this-blog-is-now-running-on-solar-po...
Post titles like these are HN's flavor of clickbait. I get that it's the title of the article, but it doesn't mean it should be the title of the post.
Cyclosporine has some very serious long-term toxicity (especially renal dysfunction and hypertension) and the availability of newer biologic agents has restricted the use of cyclosporine to patients who have not responded to conventional treatment.

*Mild tremor is common with both cyclosporine and tacrolimus use, occurring in 35 to 55 percent of patients [ 79,80 ].
*Rarely, patients develop severe headache, visual abnormalities, and seizures. This syndrome is associated with acute hypertension and resembles hypertensive encephalopathy [ 77 ].
*Posterior leukoencephalopathy is usually seen on brain imaging [ 82 ].
*Cyclosporine may contribute to bone loss after organ transplantation [ 88 ]; this effect may be due to the induction of high bone turnover.
*Cyclosporine can cause hyperkalemia and hypomagnesemia, via effects on renal tubular function. Hyperuricemia and exacerbation of gout are well-described with cyclosporine.

[77]. Schwartz RB, Bravo SM, Klufas RA, et al. Cyclosporine neurotoxicity and its relationship to hypertensive encephalopathy: CT and MR findings in 16 cases. AJR Am J Roentgenol 1995; 165:627.

[78]. Eidelman BH, Abu-Elmagd K, Wilson J, et al. Neurologic complications of FK 506. Transplant Proc 1991; 23:3175.

[79]. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. Lancet 1994; 344:423.

[80]. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. N Engl J Med 1994; 331:1110.

[81]. Wijdicks EF, Wiesner RH, Krom RA. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Neurology 1995; 45:1962.
They're also pretty cheap ($15-30), powered fully over USB—no extra power cable like in the old days—and they're tiny.