skysight-inc/HackerNews huggingface dataset:
You don’t know other aspects about his job. If the work is easy and the pay is good there’s no point in quitting unless you aren’t working from home or there’s a substantially better offer.
The virus also produces the spike protein
The Office of the Future: Studio Metaphor
I watched the first few minutes, I think I understand the angle. Do you think there is a causal relationship? I have no doubt that homeless people use drugs in a bad way, and I think homeless problems as described are disgusting and wouldn't want to live somewhere like that. But I think the homelessness and drug use are symptoms of the same problem, untreated mental illness, western society generally... people who think that more criminalization of drugs will make this better are living in a dream world. Do they have these problems in Norway and Portugal? I don't believe it's anywhere near like this, and I don't thinks it's because they are tougher on drugs (I'm open to bein told differently though). Drugs are not some evil waiting to corrupt weak people, they are recreation for most people, and a dangerous escape for a few. Pretending they are a cause instead of a symptom doesnt help anyone
The spike protein from the vaccine is injected into your muscle and does not circulate through your system.
I'm on a very similar one, which also has a GoodRx coupon.

In case you're not familiar with the details of psychopharmacology, or are lucky enough to have a more "normal" brain, it's quite common for one to spend a long time with their doctor, doing trial and error with different compounds that are variants on the same structure, even different isomers can have a noticeable effect for the patient.

At one stop on my journey, I was prescribed dexedrine, which I previously had only heard of in the context of the great Paul Erdos.

Sadly, despite my hopes and dreams, there was no noticeable increase in the proliferation of my math output.
Stray into the south and Far East. They have incredible stories.
>>What is this treachery you are talking about ?

https://en.wikipedia.org/wiki/Purnaiah

The British simply bribed this guy onto their side.

He really was more like Charles Maurice de Talleyrand-Périgord - https://en.wikipedia.org/wiki/Charles_Maurice_de_Talleyrand-...

I wouldn't really call this treachery, In fact I wouldn't even call Jaichand a traitor or anything. The are often over simplistic narratives of deeply complicated situations.
It doesn't cause damage it seems, it impairs repair, so it would have prevented DNA repair during the few days the mRNA would have created spike protein.

I have no idea how often the body needs to repair DNA and what the effects of not doing it for a few days are though.
Clay Shirky talked about time spent online versus time spent watching Giligan's Island tv. i still think of it a lot. but this article did a great job calling attention to how crypto-broadcast modern online experiences often are. thanks.
The pixels in that screenshot are absolutely enormous. Modern screens have far higher resolutions. If you can’t even see that then I don’t what what else to say.
The key finding:

> Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows that the spike protein intensely impeded V(D)J recombination. Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28].

> This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine. This work will improve the understanding of COVID–19 pathogenesis and provide new strategies for designing more efficient and safer vaccines.

In vitro findings are obviously not as compelling as in vivo findings, but it sounds like this issue is worthy of further investigation. It's a bit disconcerting to learn that the spike protein expressed by vaccines administered to over a billion people might be implicated in the impairment of adaptive immunity.

All mRNA vaccines (Pfizer and Moderna) and the adenovirus vector vaccines (AstraZeneca, J&J, etc.) express the full-length spike protein.
An array of tactile antennae/feelers?
Sadly, being completely detached from the difficulty of "motherhoood" is a pretty common form of idiocy.
Ocra: One-Click Ruby Application Builder
One workaround can be picking up a cheap domain and CNAMEing _acme-challenge.unsupported-provider.com to _acme-challenge.supported-provider-cheap-domain.com. The rest of the records can be left alone.

This is listed on LetsEncrypt as a "delegate" subdomain [1] and on an EFF article as a "throwaway" domain [2]. Some clients just call it "CNAME support" [3].

All the different names muddle search results. I've used a Reddit guide [4] for Cloudflare + goacme/lego.

[1] https://letsencrypt.org/docs/challenge-types/#dns-01-challen...

[2] https://www.eff.org/deeplinks/2018/02/technical-deep-dive-se...

[3] https://go-acme.github.io/lego/dns/#experimental-features

[4] https://old.reddit.com/r/selfhosted/comments/je2041/how_do_y...
The mRNA vaccines's mRNA has never been the problem its the adjuvant properties such as the PEG allergies and lipid nanoparticles that have been been causing all the issues. I am sure it will be improved, and they're exploring better adjuvants. When were you vaccinated? If its been a while get your booster. https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Effectiveness against infections declined from 88% (95% CI 86–89) during the first month after full vaccination to 47% (43–51) after 5 months. Among sequenced infections, vaccine effectiveness against infections of the delta variant was high during the first month after full vaccination (93% [95% CI 85–97]) but declined to 53% [39–65] after 4 months.
He said near East. The Mahabharata be ramayanan are only the best know stories out of India. There are hundreds of prominent works and millions of stories.
> "I let him know I'm here as a resource, I'm not an activist, I'm not trying to be a pain in his ass,"

> helping their local government become less terrible by working with them

Activists act, that's all it means - lots of different people doing lots of different things - they setup soup kitchens, they find housing, they run for office, they help their local government, they push it. They do exactly what Petersen is doing. Lots of different people doing different things, some effective, some not.

Petersen seems so lost in a political narrative that Peterson is poisoning a relationship with and denying all the energy and good things for our community. Petersen is, in fact, an activist.
Isn't this problem with inefficient and expensive healthcare systems another example of poorly aligned incentives? The vendors have financial incentive to build and sell systems that require long term, expensive, support contracts. Hospital administrators are incentivized to install turnkey systems (that don't require lots of their involvement), and to choose systems that provide reasonable assurance of regulatory compliance. It is simplest to accept vendors claims of improved productivity and overall long term return on investment. When the cost turns out to be higher than anticipated due to reduced productivity of staff and growing software customization services, those costs can be passed on to patients. From the perspective of the Hospital admins, and the vendors, all is well.
That doesn’t make sense.
Do you have anything to support this belief?
I've gone back to playing this. Many modern RPGs are draggy and too big. The BG games were just the right size, not too big, not too small. You can sit for an hour and have lots of fun and go back to work.
India has good material all the way into the Middle Ages and a little pat that as well.
It has nothing to do with kubernetes actually.
Another machine learning success story. Why do you need on the ground agents with knowledge of the market when you can use the Big Data?
Does Notion host their source code on github ?
The misogyny makes the stories better. It actually feels authentic.
Except the researchers raise the possibility that this could be an issue:

> This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine.
The entire country of Flanders is giving personal pods to every citizen. Its interesting to me that something as big as Solid is happening and HN is fully missing it. It's a very similar situation to Tim Berners-Lee's invention of the web, those early days where we were in awe using Mosaic browsers...
You’re talking about one owner and one house. Zillow was attempting to do it at an industrial scale.
I agree, but the mRNA vaccines factually aren't long lasting. Get your booster if you haven't yet, its important since the protection is about half in under half a year. https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
It's worth noting that WebAssembly, at least for the moment, only supports a single brk/sbrk-style growable heap -- allocators targeting the web can't use any of the mmap tricks.
> There is no shortage of money, retirement 401k and medical care for city workers.

Because this is a common anti-labor narrative which often turns out to be false, I should ask: Do you have any good sources or that?

> Property taxes are as high as any place in the USA. There is no shortage of money

Property taxes are just one form of revenue, and may not be nearly sufficient.
Love this analogy.
Like they used to be a backend engineer before? In general I consider any software engineer worth there salt can pick up a new language and framework pretty quickly. And so I tend to ignore the technologies they know, but instead look for their fundamental and ability to learn quickly.
Enlightenments main problem was using the libraries was an exercise in masochism:

https://what.thedailywtf.com/topic/15001/enlightened
You think? Who is doing do diversity and inclusion reviews? Do you think they're getting paid call center wages?
Routers/all-in-one boxes: have you looked at avm.de[1]? I have an older Fritzbox (no desire for WiFi 6 at this point). Installed by my ISP, who are all about wireless and know what they're doing. Gets frequent security updates still.

Ubiquiti was good until they had a change of management some years ago. Now, they have a reputation for Lenovo-class (or Wacom-class[2]) spyware.

For consumer wi-fi access points, Cambium cnPilot on the high end, TP-Link or maybe Grandstream on the disposable end. Mikrotik might be OK if they have fixed their security issues (#TODO: research, & update firmware on my mAPlite).

For my household (one, sometimes 2 people, about 5 devices connected to wi-fi), I'd just get TP-link. With four or more people in the house, Cambium.

1. https://en.avm.de/

2. https://news.ycombinator.com/item?id=22247292
> If they outbid everyone who actually wanted to live there, who were they planning to sell to? :P

I mean, exactly - they lost $550 million. Didn't stop them from burning massive capital reserves to outbid tons of people and fuck up the market a bit for them on a bad bet.
According to the CDC, the mRNA vaccines do NOT induce creation of the full spike: https://www.cdc.gov/vaccines/covid-19/hcp/mrna.html

> mRNA vaccines tell our cells to make a piece of the “spike protein” that is found on the surface of the SARS-CoV-2 virus. Since only part of the protein is made, it does not harm the vaccine recipient, but it is antigenic and thus stimulates the immune system to make antibodies.
> people out themselves as having never worked on anything significant
I really don't understand how you jumped to this condescending conclusion.

> the other side turns out to be fraudulent
Crypto is not here to protect you from falling victim to fraud. It is here to replace a faulty and completely outdated financial infrastructure. The same laws against criminals apply whether they use crypto or not.
This is me. I've been a Backblaze user for a long time, but I'm not sure how long, because I never think about it. I've never had to do a full recovery, but every few years I download a file.
lol ... this infact is the sample problem which Andrew Ng explains in his famous Machine Learning course on Coursera!
Mohamad.rostami2910
It’s a fair point
holy crap that was terrifying. Basically, an economist and a law professor very authoritatively talking as though the last ten years didn't happen. I guess it figures-- in America you have the Chicago school and the Originalist camp: the two shit slices of shit bread in the shit sandwich we're eating.. and everybody defines themselves relative to that, more or less. So I guess these people lack even the language to talk about community investment, generational trauma, social services, infrastructure, city budgets, civic corruption, oh yeah POLICE UNIONS, yadda yadda. Jesus christ we all live in fear of the police in the US and these guys have no idea. What a red blooded wank.. I don't even have to quote just pick any random paragraph.. jesus. Oh, props to never mentioning gun laws once! Wonderful.

What really boils my clams is the ignorance-so-profound-it-must-be-wilful of the MASSIVE roles the two classes of people represented here (lawyers and economists) have played in the fucking up and routing out of the poor in America, and of the perpetuation of our primordial slave state. it's just so damn arrogant. Kinda reminds me of Russ Roberts: perfectly smart people for whom reality just does not exist.

Maybe the unifying thread of all this is just not understanding human frailty at all, and so missing the mark on everything that depends on it.

I wonder if it's especially bad because it's a transcript of a podcast.. people might be used to hearing spew like this in audio form because of talk radio, but you don't often see it written down quite so baldly.
> I gave up because transfering 20 TB over the internet is insane: it would take days to restore a backup.

They now have a service that ships your data to you on a hard disk, and the cost is refunded when you return the disk.
Push, pull doesnt matter at this stage. Netflix and YouTube and HN etc are neither, and look at the attention they capture.

People think they can regain control. The majority wont.

Their brains have been trained for decades now to chase clicks/upvotes/views/likes and followers as if these rules are Newtons Laws or something. Different parts of the brain now are totally fubar, as in once you have been writing with your right hand for 15 years, the brain cant just, over night, rewire large chunks of the network to use your left hand. Its takes lot of discipline and most people dont have it.

Probably have to write off a generation or two before things change. Look at netflix, now that they are hitting the upper bounds of attention capture using video, they predictably move to games and shorter vid formats like tiktok to keep capturing more attention.

They have fucked up a whole generation with an endless supply of rewards and to keep people glued. And given the billions being raked in every hour they have won.
Makes sense in the medical domain where people are way more likely to be injured or die.

But most software isn't that critical.
F__a__t431
Oh boy.
So, to start, we have done scientific studies about the costs and benefits of readability (as codified circa 2018, since that was when the last study was).

It was studied for multiple programming languages Google uses.

It was done, at my request, by the engineering productivity research team, who are experts in this kind of research - you can find public papers they publish[1].

For background: I was the person responsible for production programming languages, and I did this precisely because i did not feel at the time there were recent good studies as to whether readability was really worth the cost.

The answer is "yes, it is".

There is an upfront cost, but readability has a meaningful and net positive effect on engineering velocity.

It is large enough to make the cost back quite quickly.

One could go down the rabbit hole of seeing whether you improve (or make worse) the numbers by changing various parts of the style guides, but like I said, what is there now, has in fact been studied scientifically.

Honestly, i'm not sure why you think it wouldn't be. You come off as a little immature when you sort of just assume people have no idea what they are doing and don't think these things through. You are talking about a company with 60k+ engineers. Every hour of all-engineer time you waste is equivalent to having ~30 SWE do nothing for a year.

Maybe there are companies happy to do that. I worked at IBM for a few years when i was much younger ;). All I can say is that as long as i'm involved in developer tools at Google, i'm gonna try not to waste my customers time.

[1] I say this in the hopes you don't go making assumptions about whether the studies were done properly. They were properly controlled for tenure, number of reviews, change size, etc.
For uncontested waters, yes. The problems start when one military starts trying to make charts in waters claimed by another country. That tends to become a bit of a problem.
A Prayerbook Woven by the Jacquard Loom
It seems this is the issue in question: https://github.com/Homebrew/brew/issues/9186

The maintainer did close they issue but they didn't lock the thread. If there was a very valid reason the request got shot down, it went unstated afaict. (Fair enough if they just don't allow feature requests on the issue tracker, I guess)
does the federal government not have an IRB?
edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies

>Does this finding imply that the vaccine would also inhibit DNA damage repair?

Well, yes, but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the very first paragraph -- it's been observed that a consequence of surviving a serious case of COVID is that your immune system is fucked, both during and afterward:

>"SARS–CoV–2 infection extraordinarily affects lymphocyte number and function [3,4,5,6]. Compared with mild and moderate survivors, patients with severe COVID–19 manifest a significantly lower number of total T cells, helper T cells, and suppressor T cells [3,4]. Additionally, COVID–19 delays IgG and IgM levels after symptom onset [5,6]. Collectively, these clinical observations suggest that SARS–CoV–2 affects the adaptive immune system."

Searching for a means by which the vaccine might meaningfully damage your adaptive immune system is ill-advised. Frankly, we've got terrifying amounts of information about the deleterious effects of catching and surviving serious COVID, and administration of a vaccine tends to uncontroversially downgrade the seriousness of the COVID infection that you will almost assuredly get eventually. Thus, even if the vaccine harms you in some way, COVID itself will do worse.

That said, the Discussion section does suggest that there may be improvements to full-spike vaccines in future,

>"indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]. This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike."

I'll again point out that however the spike might fuck with B and T cells, the full-blown virus will surely do more.
Please can someone who is an expert in this field explain this in simple terms for us lay people?
Yea we used old L&R ones on the ships. GPS receiver was $60k and we only got 2-3 hours of semi-ok GPS per day, but also recorded speed & heading, used some early satnav systems with fixes once in a while, and ranging navigation from custom transmitters on shore. Lots and lots of post processing of the nav to try and use it to correct the gravity data. It was pretty crude.
So they basically gave $550 million to UMC homeowners by overpaying for houses, while making it slightly harder for other UMC wanna-be homeowners to buy homes for a couple months. Not the worst outcome I can imagine
Exactly. That's just one of their poorly thought out marketing lines. Of which there are many...
> The bogeymen of "processing"

Processed foods have a well-established impact on health. Do you have some evidence tat says otherwise?

> do not make any definitive statement about the healthiness of those products

Did someone say "definitive", or maybe it's a factor. If you don't think that's a factor, what is your evaluation of the healthfulness of the fake meats?

(Is 'bogeymen' like a spell - if we say that magic word, we make something meaningless? 'The bogeyman of Covid!' 'The bogeyman of my mortgage!' This is awesome!)
That's a good clarification, but to be honest, casually from a reader point of view, saying sufficiently good does seem to imply that skill is sufficient to get the job done, thus good enough for the job.

Which I mean, if you're good enough for the job, that would be a meet expectations review, which I'd say counts as "good".

So having said that, my experience is that people who aren't at least good enough to get the job done do eventually get fired or stop moving up the latter, even if they are super nice. At least in the software engineering field, don't know about business or management tracks.
Everyone knows the org is called Apache because they Jump on it! Jump on it! and not because they're appropriating Native Americans.
> I agree, but the mRNA vaccines factually aren't long lasting. Get your booster if you haven't yet, its important since the protection is about half in under half a year.

This is misinformation. From your link:

> Vaccine effectiveness against hospital admissions for infections with the delta variant for all ages was high overall (93% [95% CI 84–96]) up to 6 months.

A post regarding a possible "issue" with the vaccines is a strange place to engage in "get your booster!" fearmongering by highlighting VE against infection as compared to the far more important endpoints of hospitalization and death.
I find I'm most likely to be right when people are responding to me with thought-terminating buzzwords rather than actual arguments
Newton was a shameless plagiarist.
> There's a whole genre of Chinese food that is based on fake beef, fake pork, etc.

Very interesting - what are they called? What are they made of? Where do they come from?
www.raypeat.com has tons of useful information, and he will respond to emails if you have specific questions.