skysight-inc/HackerNews huggingface dataset:
The same way that Delta has decimated Flu Type B/Yamagata to the point that some are whispering that Flu Type B/Yamagata has gone extinct. (The Flu is still around, but Type B/Yamagata was very, very common before COVID19 hit. It hasn't been seen for almost 1.5 years now)

Its not like "Delta-variant" gives you immunity to Flu Type B/Yamagata. But people around the world are masking up and locking down (well, in 2020 anyway). People's behaviors change when a large-scale pandemic like this occurs, and the weaker viruses die out.

Even ignoring that, COVID19 forces an immune response. Yes, this immune response includes memory-cells (which remember COVID19's signature), but it _ALSO_ increases other immune cells (Neutrophil, killer-T cells, among others) which will hunt down any virus more effectively. This effect is temporary, but still a big enough effect to see the body fight off other diseases a bit better after getting sick from anything.

So even though COVID19 / Delta doesn't give you any immunity (ie: memory cells / antibodies) to Flu B/Yamagata, you see Delta outcompeting it and driving Flu B/Yamagata to extinction.

--------

Delta transfers memory-cell responses + antibody responses (two attributes of "memory immunity") against COVID19, and Alpha, and other variants. Sure the disease is evolving, but its not like these antibodies are totally useless against the virus within the same line.

COVID19 simply doesn't evolve as quickly as the flu does.

--------

This effect, in reverse, was seen in 2020 where recipients of the standard Flu shot had something like a 5% lower chance of getting COVID19. The temporary "immune response" that your body built up for the Flu vaccine had a minor (but measurable) effect on COVID19.

Getting sick with _ANYTHING_ makes it harder for other viruses to attack you. Your body just goes into overdrive making various white blood cells.
ISO C++ is probably working on std::embiggen<T, traits, options, defaults>.
[Disclaimer: I work for TileDB, Inc]

We have developed just this[1] except using a MariaDB storage engine (MyTile) we've written. You can serverless run queries against TileDB arrays without spinning up a MariaDB instance. You can run any type of query MariaDB supports (joins, aggregates, CTE, etc). I've linked the basic documentation and an example notebook below[2]. You can run SQL queries from python/R or even JS or curl. We support a number of data return formats, i.e. arrow and JSON to facilitate use cases.

I'll also mention that we have a number of public example dataset[3] in TileDB cloud, such as the NYC taxi data used in this notebook[4], which you can explore!

[1] https://docs.tiledb.com/cloud/api-reference/serverless-sql

[2] https://cloud.tiledb.com/notebooks/details/TileDB-Inc/Quicks...

[3] https://cloud.tiledb.com/explore/arrays

[4] https://cloud.tiledb.com/notebooks/details/TileDB-Inc/tutori...
Can you provide other domains associated with this?
I’m actually thinking for side proj (I’m very familiar with running production crdb in k8s via my current job) - the usecase is to bring isolated “virtual” crdb cluster per customer to save on operational overdhead of managing many crdb clusters in kubernetes (which is doable but requires extra automation). That’s not how we handle customer mutitenancy at my current job but I’m sure this could be common usecase. Now I could use your cloud but I sure am interested in diy option as well
Do they? Where is the evidence that people who study these things acquire qualities they didn’t already have?
We're working on something like this at Deref: https://exo.deref.io/ - The version of our Exo tool that is out there now is a local process & docker container orchestrator with log viewer etc. We're working on adding support for a rich set of component types like functions, queues, workflows, cron jobs, etc. Everything would have a nice console GUI, so you don't need to be an expert at infrastructure-as-code, yet you'd get a version-controlled manifest file that you can use for reproducible deployments. We plan to support deployment to your own infrastructure or an eventual PaaS platform.

If folks are interested in working on something like this, my email address is in my profile. Don't hesitate to reach out.
Computational docking (figuring out what drug molecules bind strongly to) is still not solved. In order to find drugs that 1. work well and 2. aren't toxic we need robust docking estimators that work well over a wide variety of proteins. My understanding of the space (which comes from undergrad comp bio, so please someone feel free to correct me) is that just having a molecule that binds well to your target doesn't mean it's going to work well as a drug, because there are delivery and toxicity concerns.
> Lastly I know some people who avoiding marrying other teachers because the combined salary is less than many single professions.

I know some teacher couples that are busy coming to terms with this problem.
Well, I'm a gameplay programmer and I seem to always be busy somehow, so idk maybe you need to play different things?
stochasticism does exist? i think ...
There's a big difference though between requiring a license, and requiring that every childcare provider has a college education (like is required of teachers). Keeping a child safe is not effortless, but it's also not that hard, it can be done easily with the same diligence you'd expect of someone working at like, a fast food restaurant.
That is not the question I asked. Furthermore the degree of which the current vaccines work against variants is dependent of the variant itself, please consult the OA. (Also dependent on time, but that's a separate conversation .)

I am asking specifically if there is any hard evidence of vaccine effectiveness to back statements made by biopharma corporations about variant-specific vaccines, for example:

"We have built a process that within 95 days from the day that we identify a variant as a variant of concern, we will be able to have a vaccine tailor-made against this variant," [Pfizer CEO] Bourla said.

https://www.insider.com/pfizer-ceo-vaccine-resistant-coronav...
Gunfight, My Battle Against the Industry That Radicalized America
In Washington state, a percent of positive tests are sent to the dept of health for variant sequencing. You can see the published results by week. Delta has outcompeted every other variant for several months. All covid is essentially delta.

See page [pdf] 5 on this:
https://www.doh.wa.gov/Portals/1/Documents/1600/coronavirus/...

It is updated every Wednesday
Updates to our issue status icons and colors
I am disturbed by the hysteria and alarmism. People have been predicting "climate disaster" for 40 years now, along with population disaster, and many other disasters. I'm not onboard with this extremism, and neither is the majority of the population, and most important for you, neither is China, which is opening 120 new coal plants just this year. Yet for some reason I'm supposed to be terrified of flying from SFO to LAX and pretend that there is some sort of existential crisis.

But don't worry, this will allow you to keep warning of collapse, just around the corner, for the next forty years as well. And the forty after that.
Great choices. I love Nest.
You're maybe not saving the game to disk, but you still have to download it. At least the assets you're going to interact with. And if you want to play again, then you keep the game/assets in a browser cache somewhere and there's not much difference with downloading and installing the game, in terms of bandwidth/diskspace
I use pg-boss (https://www.npmjs.com/package/pg-boss) which plugs really nicely into Postgres.

It allows you to define task queues or scheduled jobs, and if you're already running Postgres you don't have to host any other infrastructure!
Countries with less progressive taxation (i.e. Russia, Brazil, etc) have even worse wealth/power inequality than the U.S.

The U.S. was at its most "equal" with strong unions and high inflation (1970s). Perhaps that's what we need again. Strong labor bargaining and run inflation hot for a while. Also raise the non-primary home property tax so that the rich can't shelter their wealth in real estate.
Can see it on laptop too.
second word that appeared was 'règle' which is a very common French word
It is the news media's fault. They have complete control over what they decide to publish (or not), and how. The media chooses to post misleading information for clicks/money. "But someone will pay for it" is never an excuse to do something wrong.
Yeah, especially for a company that people spend hours using and that influences electiobs
Lotus had a whole suite of office products for DOS. Lotus Works was amazing.
Thank you. I came looking for the truth behind the click. Of course, the truth is much less interesting.
I am but I am not as well.

I have found male programmers to have a more diverse dating/marriage pool, though most are still "tech"-y office jobs e.g. designer. That's just middle/upper middle class sticking together though.

Female programmers I've met almost exclusively date or are married to other programmers.
- Pricing

- storage and db access is still mostly through hoops

- long running processes

- pain to develop, test and debug
I'm not in the ruling class, so I would not say "monetary theory (modern or otherwise) is doing just fine". Perhaps nicoffeine is in the ruling class?
Googler:

https://www.thisworddoesnotexist.com/w/googler/eyJ3IjogImdvb...
The generated "using it in a sentence" examples are often the funniest (and most absurd) part:

chokebone
choke·bone
the muscle holding a prisoner down, used in controlling an animal or person such as a cat, dog, snake, snakebite, or spider
"he managed to regain the chokebone and win the auction for his 12-year-old daughter"
Computer programmers and software developers are in separate groups. Developers marry eachother more often than programmers do, whatever that means.
Unfortunately, the statistician or data scientist that put this visualization together neglected to include statisticians and data scientists in the list of searchable jobs.
Not surprised by lawyer. Only other lawyers can understand the long hours and stress.
As much as I hate Oracle, it is damn fast.
So it overflows the chart on desktop Firefox for me, but, the buttom axis caps out on the right at 22%. It looks like they hardcoded the graph axis, and so since other agricultural workers are at 23%, it overflows.
Well it topped out at ~14%. At least it suggest women in programming quite heavily preferred their counterpart coders.
`objdump -T node_modules/@next/swc-linux-x64-gnu/next-swc.linux-x64-gnu.node | grep GLIBC_`

Looks like the highest version of `GLIBC` is 2.18, so I think you'll be fine!
> start a trust

I'm assuming this plan kicks off at death, so your trust wouldn't need to spend much to maintain itself.
You're talking about consumer price inflation, I'm talking about monetary supply inflation.

A basket of consumer goods and services is a nonsensical way to hedge monetary inflation under anything but the most extreme conditions, since those things should be getting cheaper as production processes/technology/understanding of the world improve.
I usually don't believe in this stuff and think it's coincidence, but it does happen very often.

One thing that happened in my case, I think I was discussing with someone at a table-tennis club about someone playing squash and he showed me a livestream of that guy playing squash. When I got home I started seeing ads for places to play squash even though I never searched for it on my phone, but this is what I think happened: my phone and his were on the same network, so someone the ad-network associated my device with the "squash" keyword because another device on the same network searched for it.

I think this is usually what happens when you "discuss" with someone, that person or someone else in your proximity might search online for that thing and your device will be indirectly associated with that search.
Paging Doctor Ampersand. Please come to the courtesy desk.
I don't worry about a lot of the NIMBY with self-charging. It'll be like bike lanes, once people discover they increase property values, or at least keep them from sinking, it will be a done deal.
Wouldn’t you be able to have a heat floor heated by your wood? If wood is cheap where you live heating water with it is a nice upgrade from a basic wood stove.
> This doesn’t exist except in the imagination. It has no causal bearing on any economic process except through the influence it has on the person imagining it.

No, it exists in math, with addition and subtraction. Like I said, a publicly traded bank account like a SPAC has an intrinsic value equal to its cash on hand. This is the economic definition of intrinsic value, and you're trying to once again substitute your epistemological definition. Same word, different meanings in different contexts, and it's disingenuous to try and substitute your definition as though it's the commonly accepted one in this context.

> So does EUR with respect to USD

This does not follow. Money isn't an asset, it's a currency, and a foreign exchange trade is a pair trade on the relative domestic purchasing power of the two. Currencies do not float with respect to other currencies because they are not priced in terms of each other.

> Scarcity, fungibility, liquidity, durability, portability - gold’s 5/5 and real estate is 4.5/5. What properties are you thinking about?

Ok let's talk about real estate. It's not fungible, each house is different. It's not liquid, in fact, sales take a substantial period of time. It's not necessarily durable, it decays without constant upkeep. It's totally not portable. And it's not broadly accepted as money. That's 0. Try bringing your deed to the Apple store to buy a MacBook. How is that 4.5 out of 5?

Gold of course isn't broadly accepted either, so that's a critical one. Try bringing a gold brick to the Apple store and see if you can buy an iPhone. Yes it could be money, it was at some point, but we replaced it because it was bad at being money, and these days it definitely is not.
That's not the position that Haugen took testifying before Parliament in the UK -- where she expressed strong support for e2e encryption. She said her views had been misreported earlier -- that she'd questioned whether Facebook could be trusted to implement e2e properly, and that the reporters had garbled it.

See, e.g., https://twitter.com/sleepdefic1t/status/1452724217393434636
This here folks is why hiring out of FB is dangerous.

They've accepted the Zen of Zuck as being the way and are unable to see any moral or ethical ambiguity.
My old company used S3 to sync config files in json. S3 is strongly consistent now
I never said it supports AST transformations directly. I just said they were trivial to do with esbuild.

Our build times remain at 0.5s with pretty extensive source transformers in JavaScript plugins in esbuild. This is down from 5-8 minutes using rollup.
Over-engineering is not exclusive to the JS world. It's just in the spotlight nowadays. Rails also just hides its magic well because of Ruby and most experienced devs are already used to the Rails magic so its simpler compared to the new stuff like Next.js.
Over half of the first bunch I got came up in Wiktionary.
The amounts could just be tied to the steps. So maybe step 2 is to add 3 tbsp of ingredientX, and step 5 is to add 1 tbsp of ingredientX. So programmatically, the ingredients list would be the cumulative amounts of all ingredients described in each step, which would be 4 tbsp ingredientX.
This has a real Silicon Valley (show) tethics vide to it.
As an alcoholic, if you depend on that one drink every day and CAN'T go without it, you are an alcoholic.
Even completely leaving aside the language/software diversity, the point is that the vast majority of web "frontends" are really just one thing (rendering the UI and responding to inputs) whereas web "backends" are frequently not really one thing (1 or more types of storage, 1 or more types of computation, responding to requests, perhaps event processing and scheduling, etc.)

I did not mean to imply that all, or even most backends are more complex than frontends -- only that the problem space of backends is larger and more varied (for typical web use these days, at least.)
Many anecdotal guesses are validated by this data. Doctors and agricultural workers are the obvious standouts, but I see a few more too.

Us programmers stick together. Quite a high rate of marrying within the community. Lawyers show a similarly high number.

A criticism of the study, is that it does not normalize by how many of these professions are in the general population. So, it appears as though software analysts don't like intermarrying. However, the truth is that there simply aren't enough of them around, they are simply more likely to run into software engineers, so that's whom they marry most.

IE. This study captures P(running into a profession) x P(preference for that profession). I would love to them model P(running into a profession), so that we could get the much juicer preferences of each group for various professions.
I'm having trouble finding the paper, but I'm pretty I've seen a pre-print for mRNA-1273.351. This press release is the closest I could find on short notice: https://investors.modernatx.com/news-releases/news-release-d...

Novavax has also been working on a Beta variant booster (and I believe has moved on to a Delta booster that hasn't started NHP trials yet) -- here's some info from a presentation: https://www.novavax.com/sites/default/files/2021-05/NVAX-WVC... (It's slides 17 and 18)

Pfizer/BioNTech definitely has a Delta booster getting ready for NHP trials, but my Google Fu is lacking today, apparently.
And you end up with tons a network calls and services to monitore, logs, manage and pay.

I'd do the exact opposite by default, trying to have the most cohesive service, and occasionnaly use some external APIs when I can't do the stuff by myself (eg. Stripe)
Ooh! Now all I need is a replacement for Better Touch Tool.* Anyone know of anything?

* which I use almost exclusively as open/close new tabs in Safari and Finder with the top right and left corners of the trackpad respectively; plus three-finger-swipe left/right gestures to move between tabs
>Crown corporation in Canada isn't running any industries though, it is just an organization for providing government services and isn't any different than a typical department of education or post or government rails etc.

An oil extraction and distribution company isn't an industry? I also suggest you read the second link in the grandparent: Nova Chemicals, Yara Belle Plaine, PotashCorp, all the resource extraction corps in Saskatchewan...

Also, that's strictly wrong -- Crown corporations could operate in any sphere of business at all, so long as the government chose to endow them to do so. Furthermore, some Crown corporations must deal with real physical externalities arising as a consequence of their operations, like Petro-Canada, which (before it was sold off for a song to already-rich people) extracted real physical oil in Alberta, and dealt with the real physical externalities in a much MUCH *MUCH* more accountable way.
Why are chief executives and legislators grouped together as one profession?
ROI may be positive for many programs but still only worth it for a few of them.
This would be great for generating passphrases:
"correct horse battery staple" becomes

hippoglossia periceptor wharfoon northerl

Good luck guessing that one, hunter76!
As a native French speaker, I would say Comirnaty is actually easier to pronounce than Spikevax, and I suspect it might be similar in other Romance languages.
The main trouble with GIMP (and Inkscape) is lack of first-class CMYK, making it irrelevant for any print-targeting activity. Otherwise the features have advanced in the last few years and the coherence is not bad, the photoshop crowd being in the same ballpark for me.
Just curious: what's the connection between paella and Arabs? I lived in Valencia for about 15 years and never heard of this.

In Valencia, it's popularly accepted as a fact that the origin of paella is in the Albufera region next to the city.

I don't mean for this to sound snarky, I'm no historian and my knowledge about this is purely casual.
I got "underpenetration", which seems kinda like a real word.
> "Are you going to get lung cancer too, dad? Please quit!"

This would definitely have a negative impact on a child growing up- feeling like I had to worry about my parents' health when I was ~12 definitely did.
these are all the ones I collected

shibget.com

shiba2021.pro

shiba2022.com

shib-event.io

shibaceo.info

Shiba-Gives.org

shibaevent.pro

takeshiba.info

shiba2022.org

shib-pump.net

shibevent.pro

shibashib.com

shibget.com

shibashib.io

event-shib.cc

Gift-hex.net

hexgift.org

Algo-invest.org

bch-bonus.org

GIFTXRP21.COM

arkinvest.io

hex-gift.org

gifthex.net

dropeth21.com

eventshiba.net

eth-moonevent.com

xrp21.info

eventshib.io

shiba-inu.us

big-event.co

shibget.org
Idk. Is it? I don’t think there is a clear cut answer. Should the poor serve shorter jail terms since they make less money and therefore have less time post-jail to accumulate lost earnings?
DearPyGui 1.0.0: A GPU Accelerated Python GUI Framework
No yikes. This is a standard response - deflect and deny when caught. China is engaged in all sorts of cyber warfare, and it's making hardware choice difficult. You have to scrub every device, and even then you have to observe network traffic to see if there are hidden systems trying to phone Beijing.
OCK Khouribga vs. Rapide Oued Zem – Goals and Highlights
> It's just being papered over with currency debasement

It's also papered over by things like Norman Borlaug's agricultural revolution and supply chain innovation. Even with crappy broken supply chain, americans are not starving in the streets at depression-levels. But a whole lot of other stats support your hypothesis. Like mass exoduses from state to state.
The SaaS Security Posture Management (SSPM) Checklist
It's also worth noting that the most people still had antibodies effective against A.30-- just not as effective. So the existing antibody response would be expected to slow infection and then the body is primed to broaden the variety and quantity of antibodies after infection.

It's only a small portion of those receiving the AZ vaccine whose serum had no significant activity against A.30-- all of those with the mRNA vaccine did and most of those receiving AZ did.
They haven't found original antigenic sin so far. There's a couple links with some data (although I couldn't find a pre-print or published article right now) in this comment: https://news.ycombinator.com/item?id=29005187
at least for identifying variants, you don’t necessarily need to know the full (highly complex) structure of each variant, just the relevant diffs from the original variant, and computer modeling to tease out whether the diffs are significant enough to warrant a ‘variant’ label (along with epidemiological data, of course). once identified and labeled, pcr can give you enough information (via the differing prevalences of short sequences of dna/rna that act like unique fingerprints) to tell the variants apart without needing to know anything about the structure.
Amazing work Dave. I’m super happy to see the book finally being published.
Good catch. I didn’t see the bottom axis. Edited my comment accordingly.
Ah. Right. Duh. (I must be having an even worse day than I thought.)
Esbuild doesn't polyfill, it's a bundler that also transpiles.
Revolving doors
Studies examined why narcissists often rise to positions of power at wo (cont)
Yeah that's the Agile I added a caveat about at the end.