skysight-inc/HackerNews huggingface dataset:
Ch = Chimpanzee
Ad = Adenovirus
Ox = Oxford

This is a speed-up that pre-dates the mRNA trick Moderna had been working on, a virus from chimps (so humans aren't immune to it because it wouldn't infect humans normally, yet chimps are similar enough that the virus can get into a human cell) but hollowed out to make whatever you want instead of more copies of itself. You put any payload inside it and it'll re-program the patient's cells to make that for a brief period until the immune system cleans up the mess. This vaccine uses the spike protein as payload to train your immune system.
When this was posted last time, I read it as "This WOD (Workout of the Day) Does Not Exist". It inspired me to make a workout generator trained on workouts from crossfit.com using a character-level RNN.

A year removed from it an I still laugh at some of the ridiculous workouts.

https://thiswoddoesnotexist.com/
In my very honest opinion, pg's essays, with some brilliant exceptions, are at the level of analysis that would be considered exceptional for a middle school student, average for a high school student, and "why are you wasting my time with platitudes" for a grad student.

But when I published my essays, I have 5 readers including my mother, so take my opinion with a grain of salt.
That's basically what Sucrase.js is:

https://github.com/alangpierce/sucrase
Same question, especially that if someone is infected with delta he can only infect someone with delta. So delta can be outperformed at the person level only if the person is infected by both variant at the same time.

For me the only way a variant can be outperformed is that all people who get infected get also infected with the other variant OR the first variant for whatever reason stop being transmissible
Some decades with very old population, and many countries are headed in that direction.
On an LAX to JFK trip, magnetic variation changes from 12E to 13W, or about 1º per 100 miles. In a case of falling back to magnetic navigation from a GPS/INS failure, this would represent an insignificant increase in workload (on that trip; around the magnetic poles, it's higher workload, but it's already higher workload to do magnetic navigation very near the poles).
For a moment I thought Postgres had a mechanism to simplify doing this.

I see this same "shadow table"+trigger pattern with other databases too.
Ed Sheeran tests positive for Covid 19
Venezuela also nationalized every sector of the economy and handed the reins to Chavez/Maduro's corrupt buddies. Not sure why you think hyperinflation is a problem as opposed to a symptom of their failed institutions.
Symphony itself brought quite a few concepts from Rails to the PHP community. You can call the flow of ideas across communities "reinvention" but I think it's super healthy.

The web platform has had been an oddity in asking you to entirely switch languages when moving between backend development and frontend development. I think one of the most appealing pieces of these Javascript frameworks is that you can build everything in one common language. (You can—but don't have to.)

Fine-grained developer control of when data is fetched, when components are rendered, how they are rendered, and where they are rendered (server vs client) becomes a really welcome advancement.
Universal: Custom-floating point numbers for C++
On Free Software, Education in China and the Covid-19 Pandemic
"The radiation portals that were deployed in the aftermath
of 9/11 are essentially fine, except for three problems:
They won't find a nuclear bomb, they won't find highly
enriched uranium, and they won't find a shielded dirty
bomb," says Stephen Flynn, a terrorism expert and
president of the Center for National Policy. "Other than
that, they're great pieces of equipment."

In other words, we only have a "security theater" ability to prevent radiological weapons from entering the border. Like the TSA, this theatrical security creates jobs, consumes tax wealth, and enables politicians to say they took action to address the problem while simultaneously giving them someone to blame when an attack occurs.
Question from a non-molecular-biologist:

IIUC, when COVID first gained notoriety, there was a large public effort to solve its molecular structure [0].

Articles like this seem to imply that they've solved the structure of numerous variants, making me think we (collectively) can do it much more quickly now.

If that's really true, what's changed? Does knowing the structure of other COVID variants give us a massive head start? Or has there been a massive investment in computing power for solving COVID-variant stuctures?

[0] https://foldingathome.org/diseases/infectious-diseases/covid...
In theory, no. There is no reason to think this neural net will output every possible string given enough time. That'd be quite unexpected.
Can't blame him, the tactile and auditory feedback is awesome. Mine is 1 year older than me and still works great.
Perhaps you could provide some insight into why? I don't see how multiple personality disorder is a very useful characterization when you're describing a community made up of multiple personalities.
my hometown in Texas has done this regularly since i was a child, when mosquito-borne viruses hit there. they aired notices about spraying nights on local TV news, on the radio, and published schedules in the papers.

i remember my parents discussing it with me and reading editorial debates in the paper.

not providing notice seems like a serious failure and i'd encourage you to give them legal/financial incentives to do so in the future.

edit: some other commenters are dismissing this as fake, so here, the CDC has an informational page on truck spraying https://www.cdc.gov/mosquitoes/mosquito-control/community/tr...
OpenSSH also supports "bookmarks" (ssh_config) and sftp.
I don't think the comment was about "too much bad stuff on facebook" at all, rather it was about how an actual facebook employee, who now works for the dnc, is forming a group that will advocate for policy that will affect facebook. When this happens in the banking industry, we call it regulatory capture. When it happens in the insurance/healthcare industry, we call it regulatory capture. When a board member of an oil company is appointed head of the epa, we call it regulatory capture. Why is this case any different?

(here's another way of looking at it: if the guy was hired as a "data scientist" by the republicans, wouldn't you question his motives?)
Well, there is also the fact that there are fewer really good tech jobs in Europe that would hire those maintainers. (I am European).
Maybe. I probably don't relate well because I talk to maybe 10ish people regularly.

Everyone else, if they don't migrate to a secure and preferred method, I just use email (with pgp if possible) and call it good.
adjective.
unprestigious
un·pres·ti·gious
(of a person) strong, imposing, or impressive
"an unprestigious figure during his lifetime"```

(https://l.thisworddoesnotexist.com/u749)

Hmm. I think it might need some more work. I mean, there's a strong argument that unprestigious is not a word, but if it was, that certainly would not be the meaning.
I agree that Pixelmator Pro is fantastic. However, I'm not an advanced photoshop(-like) user or photographer in the slightest, so there may be some advanced features in modern versions of Photoshop that Pixelmator, being a product from a much smaller company, just can't ship as fast or as well. I'm not outright saying there absolutely are, just saying that's possible.

As for other alternatives, I've had good experiences with Affinity Design for vector work. Sketch is a favorite with many designers as well (although I personally am not fond of its workflow/concepts but that's just me, clearly it works for most folks). GIMP, while venerable, is aptly named because it's so butt-ugly nobody with any actual artistic talent cares to use it. Seriously, never have I seen anything created with GIMP that looks, aesthetically, competitive with designs created with commercial tools (this isn't the fault of the functionality within GIMP, just an unfortunate side effect of having engineers do art; we suck at that). I've heard good things about Krita but haven't used it seriously because the other tools here do a great job so I've never had to bother.

It's a damn shame Photoshop and other Adobe tools are essntially malware these days. They used to be fantastic back in the day.

I swear I still have left-hand muscle memory for Photoshop editing baked into my hand even now, 20 years since I last used it routinely. ESC, hold space, click + drag, V, hover, click to select layer...
Madrid has 9 months of winter and 3 months of hell (nueve meses de invierno y 3 de infierno).
I've not seen much reported in the way of clinical trials / peer-reviewed publications for modified vaccines that target (the spike protein of) these variants of concern that are actively circulating.

Is there ongoing work here I'm missing? What progress has been made? I'm somewhat surprised that almost a year on from the initial vaccination roll-out in the UK we're now dishing out boosters which are .. identical to the vaccinations given out initially.
Give a reason when using suppression statements
Correct. `-Ofast` claim to fame is it enables `-ffast-math` which is why it has huge warning signs around it in the documentation. `-ffast-math` turns on associativity which is problematic for Kahan summation. Rather than sprinkling in volatiles which pessimizes the compiler to no end, I would recommend annotating the problematic function to turn off associativity [1][2].

Something like:

[[gnu::optimize("no-associative-math")]]
double kahanSummation() {
...
}

That way the compiler applies all the optimizations it can but only turns off associative math. This should work on Clang & GCC & be net faster in all cases.

This is what I mean by "If you're sprinkling volatile around, you probably aren't doing what you want" and are just cargo culting bad advice.

[1] https://stackoverflow.com/questions/26266820/in-clang-how-do...
[2] https://gcc.gnu.org/onlinedocs/gcc-4.7.0/gcc/Function-Attrib...
It has an X server built in, which has come in extremely handy. Yes, there are other X servers for Windows, but with mobaxterm I don't need to faff about configuring it, and it's a nice terminal otherwise, so when I realize I do need to pop open a graphical program on a server, I can just do it with the terminal I'm already using.

The drag-and-drop file transfers are also great.

Yes, you can get a lot of this stuff with WSL, but my work laptop doesn't play nicely with WSL at all (some interaction with the antivirus reliably BSODs).
You may be confusing Pax Technology (paxtechnology.com) with Pax (pax.com), a brand of cannabis vaporizers.
The few I tried didn’t make much sense. Like:

electrochromium
elec·trochromium
an extremely thin blue or red spot or color
"the scene had a vivid green electrochromium"
> even copyrighting them

copyrighting isn't (at least, in US law) a distinct action people take. If it is subject to copyright, the it is copyrighted on creation by operation of law.

> when X already exists in the real world

To the extent that a thing is copyrightable by nature , coincidental existence of an identical thing doesn't make it any less so. It might make it difficult to prove it as a creation rather than a copy if challenged (or to prove that an alleged infringement was a copy of it rather than the identical doppelganger), though.
This is pretty good. There's a logic to language that allows this (along with all sorts of other domains).

I remember trying this with a friend of mine back in high school, making up realistic sounding words in order to chun each other, making the other believe it was a real word. The natural path is to go Latin (chromozymatic), but sometimes you find a simple sound that ought to be a word.
Super weak, I wondered if that was the case. Lame troll then.
Yep they're strong contenders. Canada's regulators have been pretty friendly.

This presentation by Seaborg is pretty interesting though: https://www.youtube.com/watch?v=x-Dz9sfBKEg
I think the political writing on the wall is that the legal barriers are going to be lowered for entering the public market. So Sequoia and others are going to need to market themselves to founders as an alternative to going public.
Might want to add a filter. The seventh or eighth word I got was a racial slur: n-word bar (compound word I don't care to type).

That's the problem you get when you feed the whole Internet into your training data.
The only problem I see about this post is that asking big companies to fight against trolls otherwise it hurts small companies.

While no one would legally admit that and putting aside morals, isn't it what big companies want anyway?
I, for one, do not like this. Software that doesn't exist on your computer, but instead gets ephemerally downloaded from a server somewhere when you wish to use it, is about as anti-user-freedom as I can possibly imagine. I can ony hope this doesn't become the standard.
How many rigorous studies have been performed testing your hypothesis?
>Cost increases to whom?

I provided a link to the article so that interested people could read it. It's all laid out quite nicely: health care costs.
eletronic
(of a word, expression, or development) affected by chance but more likely to cause sorrow or disappointment
"a vivid eletronic expression of grief"

Too real.
I was just talking about Windows in general, not WSL.
We need new data books, so we published one
"Shop smart... shop s mart!"
"...PAX is now claiming that the investigation is racially and politically motivated.”

yikes
College wouldn’t need to provide a good roi if it were much mess expensive. Just like, strictly speaking, going to a movie doesn’t provide a good roi.

It’s one thing to take four years of your life deepening your thinking ability and stretching your mind without a good roi if you come out the other end without crushing debt and prospects for employment that can sustain you, even if those prospects have nothing to do with your college experience. This is what college was like until the last four decades or so.

It’s entirely another to come out the other side in crippling debt and no prospects for any kind of sustaining job.
> How do you determine true north with a GPS system?

def true_bearing(magnetic_bearing, location)
magnetic_bearing + gma(location)
end

And that's the point - your true bearing is a function of your location.
Yes, ground source/loop is considered geothermal.

The problem is that you need to a dig up a large area of possible natural vegetation to do it.
I’m sorry if my tone is not coming across as I intended.

I think there’s plenty of arguments to be made against Facebook’s integrity effort, and plenty of that work happened on Guy Rosen’s shift.

But your feedback is not nuanced and seems to be avoiding a lot of the context on purpose. It seems to be about getting people enraged through an implied accusation in your first comment.

In reality there’s some things you should consider:

- Onavo started as a “compress your data to save you money app” (I used it back then for a while)

- Seems like they found making money from selling market research data from aggregated users is a more visible business than getting customers to pay (way before FB purchased them)

- customers willingly installed the app, they got value from it, and not one customer actually got hurt (correct me if I’m wrong)

- Onavo was popular in countries with censored internet as a free workaround

- selling or using aggregated market research data is not illegal. It’s practiced by all of FB’s competition at the time (Apple and Google have control of their platforms and I’ll guess use this data). Other equivalents include Uber’s credit card as a way to see where people spend money on what transportation and restaurants.

I’m sorry if you find any of this condescending, this is not my intention. I just wanted to clarify what’s your issue with Guy is. That is all.
Am I sure of what? I never said I thought it would be cheaper or faster.
I got "reconnaisance", which is how I spelled reconnaissance once in a spelling bee.
"[...] the variant A.30 [...] was detected in several patients in Angola and Sweden in spring 2021 and likely originated in Tanzania".

As Western liberal democracies can't outcast "the unvaccinated" fast and hard enough, nobody cares to explain what exactly is the plan to timely vaccinate billions of people living in poor countries.
The final results:

- Blazor is here to stay: 42.3%

- An active community fork: 12.4%

- A "life support" scenario: 13.8%

- Use another framework now: 31.5%

https://twitter.com/noseratio/status/1452598283063357443?s=2...
uBlock Origin does too as far as I can tell.
Has it? I thought there was promising result with catching COVID and then being vaccinated (though you've already caught COVID, so you've failed the whole "don't catch COVID" objective), I wasn't aware there was good research for the opposite.
> Since matrix is focused on privacy etc I assumed this is available as a container/VM I can run at home or on a VPS.

All bridges, and the matrix homeserver itself have been open source and self-hostable for years. I host a homeserver + some bridges myself.

This is just the sugar-coated SaaS for people who dont want to do it themselves.
Agree, it gives you pretty low-level access if you need it, but you can still draw a triangle in under 100 lines, e.g. https://github.com/morzel85/webgpu-wgsl-hello-triangle
I would not associate myself with people who are concerned with the make and model of a rental vehicle. Or any vehicle for that matter. It is snobbish nonsense that should be shunned.
Rumble Acquires Locals to Help Build a Bigger Creator Economy
There are multi tests today which can differentiate between variants without sequencing.

There is also a way to differentiate on some RT-PCR tests (but not all), depending on how they are made.
Could you expand on the "privacy issues", please? Not sealioning or whatever, I am genuinely interested.
"The game comprised two teams of three (a captain and two guests) who would compete to earn points by determining the correct definitions to obscure words. The teams took turns to give three definitions, one true and two bluffs, while the other team attempted to determine which was correct. If the correct choice was made the team earned one point, if not, the bluffing team earned one point. Both teams took turns turns bluffing and determining definitions.

Examples of words used in the show, taken from a 1972 book published in connection with the it, include "queach", "strongle", "ablewhacket", "hickboo", "jargoon", "zurf", "morepork", and "jirble". "Queach", for instance, was defined as "a malicious caricature", "a cross between a quince and a peach" and "a mini-jungle of mixed vegetation". The first and second of those were bluffs. "

https://en.m.wikipedia.org/wiki/Call_My_Bluff
I just got "dispouse" which would be the perfect name for a divorce startup.
> The problem with US politicians is that they are sold out to the private sector. This is a problem that would obviously not exist if there was no private sector

You are diagnosing the symptom and not the cause. Politicians selling their power to the highest bidder is a symptom of politicians being corrupt and using their power to enrich themselves. Removing the private sector would give these corrupt cronies a lot more power to enrich themselves, that woudln't solve anything at all. Instead of having people with money and people with military power, you now have the same people having both power over industry and power over military, do you really think these people would now start caring about the environment over how much those factories are producing? No, these politicians still enrich themselves, they run these factories to make themselves as wealthy as possible and now there isn't even a government to stop them since they are the government.

Modern capitalism is based on the separation between capital and state. We call it corruption when capital is used to buy political power, or when political power is used to buy capital power. Communism is the merging of capital power and political power and giving this to the same ruling class, it is the ultimate form of what we in the west calls corruption.
About the same amounts of pests every summer, so I'm not concerned. If the winter comes fast, like 15 C one day and -15 C the next day, many will die and there will be less of them the following spring, but at the end of the summer they have usually recovered. I think the lack of pest are due to use of pesticides and lack of habitats - rather then some doomsday coming.
Sure, there are plenty of bad attorneys.
When reading a recipe I always end up mentally translating the prose / steps into a DAG, but I don't have enough short term memory to keep the DAG in my head so I'm constantly re-compiling as I'm working.

When I write my own recipes (on index cards or whatever), I explicitly create the graph to make it easier to follow. Of all the links in this thread, the "Computerized Cooking" one most closely models my ideal setup, but I don't love the RxOL language. Maybe I'll make an s-exp version of it that exports diagrams someday.
That's what meant, mistyping or forgetting your PIN under stress is plausibel, but you can always face unlock or make a iris scan.
You don't even need to be conscious to do it.
Covid: How worried should we be about the new AY.4.2 lineage of the coronavirus?
Ah. Sorry to disappoint. The technique was just new to me, so I thought it was worth sharing. :)
Plus, if those employees get Fund shares and sell them back to Sequoia for cash, that opens up room for more investors to enter the Fund without any dilution. I can imagine some closed growth funds might have a hard time finding sellers.
https://en.wikipedia.org/wiki/File:Tritium-watch.jpg
https://en.wikipedia.org/wiki/Tritium_radioluminescence
Don't forget to also use Mobian on a smartphone: https://mobian-project.org.
Now, I miss Miranda. It was a multi protocol messenger I used for icq, aim, and jabber. Friends were more into trillian. But one always had bittlebee, I somehow envied this...
AMD tried to do this a decade ago with their APUs. It flatly flopped because they couldn't get the buy-in from software makers. That buy-in problem still exists today.
Globalized newsrooms...aka coordinated propaganda and censorship.

Trump did everyone the favor of opening their eyes to how fake the mass media is.
No, there are not solved structures for these variants (in general). They're using computer modeling.

Even if there were, changes of a single amino acid that don't induce significant conformational (shape) change are the sort of thing that you'd need a very good structure to discern, since they're mostly on the surface of the spike, and probably spin around a lot.

The most relevant thing to know is what a mutation / mutations looks like in the context of antibody binding, but that's even harder to get a good structure. It's not something that can be done quickly.
The gold standard was abandoned because it is a terrible idea for civilizations that have technologies like accounting systems and currencies that are difficult to counterfeit. Tying economic expansion to the ability to mine and store one type of element doesn't make any sense.

There are countless asteroids out there with quadrillions of dollars of precious metals. Does that mean the first private company to create a currency "backed" by a claim to one of them is worth more than the US economy? No, of course not. The US economy produces food, shelter, water, goods, services, etc etc. It's worth far more than a chunk of atoms. Even if you could magically spirit those atoms into a vault somewhere, what do you do with them at that point?

Modern monetary theory is doing just fine, and so are all of the nations issuing fiat currency, selling bonds and notes, building infrastructure, and providing fertile ground for markets to do interesting things. Nostalgia for the gold standard is just way for people to claim the superiority of economic theories that are simply not useful anymore.