skysight-inc/HackerNews huggingface dataset:
Yeah, perhaps I should have thought about that solution before I asked the question it's sort of obvious when you think about it. Anyway, from yours and various comments from others, the consensus is that the d-tartaric acid method is the most likely approach. (That got me thinking, I've some supermarket tartaric in my kitchen with the herb containers. Until now I've not given much thought to its stereochemistry, but this story has almost got me enthusiastic enough to check whether it's chiral or meso. Polarizing filters off my camera ought to do the trick.)

Until this article, I suppose I'd had a rather naive view about such matters which I gleaned years ago (can't remember from where), that was that with any drug (or any other chemical for that matter) that had 100% 'd' or 'l' enantiomers then it had to be manufactured in (come from) a controlled industrial process due to the complexities of separation.

The trouble is I've only had a peripheral interest in the matter so I'm not up to date. Until this story I've been stuck with the old orthodoxy, which was that if law enforcement found 50/50% racemic mixtures then they had to come from illegal sources. Clearly, that's no longer the case, and it seems that it's been so for sometime, especially so with drugs made from pharmacy-grade precursors, pseudoephedrine, etc. - the pharmaceutical industry having done the hard work.

It also hadn't really dawned on me that mega cartels were employing professional chemists but it actually makes much sense given the mega dollars involved
(I'd always assumed there were maverick and eccentric chemists around but never envisioned an illicit lab with a corporate structure run like a normal commercial chemical company).

Also, one could be forgiven for having missed the fact because for decades, news reports have painted a constant image about the dangers of street drugs due to their variable nature (not to mention their adulteration - being mixed and cut with dangerous substances in the midstream distribution chain). Coupled with the all-too-frequent TV images of makeshift labs in jungles with buckets of chemicals littered about everywhere one wonders how they produced drugs with any reasonable degree of purity at all. The last thing on my mind would have been that they'd have had the expertise or facilities to separate racemic mixtures. Clearly this preconceived notion is now outdated.

HN comments here have updated my thinking, they're very helpful and informative at times.
This reminds me of Microbadger that Liz Rice started with some of her friends. It's very similar.

I like the integration with CVEs.. So what's the longer term vision here for contains.dev?

https://github.com/microscaling/microbadger
That’s a wildly crappy investment if you get out the same or less than you put in in real dollars.
>If you take two populations of otherwise identical people and then isolate them from each other, they'll diverge over time. Maybe the land is different, or the weather, and some genes are better adapted to one place or the other so they become more common there.

By these logic every form of life it's the same since all evolved from the same unicellular organisms.

And yet my cat doesn't have leaves while my plant I keep in the pot doesn't meow.
That was a good read.

That's a thought about killing an entire planet by burning it's atmosphere. Cliche thing but "burning hole in atmosphere". Reminds me like ants on a rock.
Houses require an ungodly amount of maintenance that is rarely if ever properly accounted for.

Why do you think large rental firms only want to rent out corporate properties or large apartments?

The average homeowner should expect to spend between 1-5% of their house value in maintenance a year - and that amount begins to climb as the house gets older.
With a web app you're able to use the same app on your laptop. And it doesn't lock you in to having to buy an iPhone for your next phone.
I wrote this style of blog all the time. When doing any kind of "discovery", I always just open notepad.exe and write some keywords, short notes, and reference URLs (most important) along the way, not specifically for blogging, but just need them for my own process.

Once done, and feel like I can write a blog about it, I would redo the whole thing (and take the screenshots) for the blog article.
U.S. spy agencies say origins of Covid-19 may never be known
Yeah idk, the compounds, basic laws of physics, let time accelerate quickly in many iterations.
Counter-Strike GO skins are non-fungible. In that they have different float value of wear parameter and in some cases texture placement.

In the end that really doesn't matter, each version for same weapon is listed under few categories. And for players it mostly doesn't matter which one they pick. So even in the case we have good example what non-fungibility is, it really does not matter much.
Updated Assessment on COVID-19 Origins: https://www.dni.gov/files/ODNI/documents/assessments/Declass...
You mean Snapchat?
Ah another RIR team member.
So, Snapchat?
I should have clarified table storage specifically, to gain intuition on what happens when data is copied between DuckDB and Arrow/Parquet. Was much faster to just look at the code bridging the two and back track from there. Thanks!
Prices are going up! Buy now before it’s out of control and you miss out!

Prices are down! Buy now to get a great deal!
It seems pretty obvious to me that if we turn the whole internet into Third Life, it will quickly devolve into groups of people standing around and shouting at each other. And that test drive? Even assuming a few people do actually want to do that, 30 seconds in, the car will be full of monkeys and the wheels will turn into cake because the sim was coded by humans on a budget and some 12-year old was bored.

As ever, the grand vision totally ignores the realities of human nature.
> There are many very smart people at these companies and Mark Zuckerberg has consistently shown himself to be a canny and innovative founder (even if you dislike him for whatever reason).

There is good reason to be skeptical given the long list of failures and Zuck hasn't shown why his take would be different yet - to my knowledge.

In the words of Morpheus from the Matrix, "Show me."
To be fair the current housing situation is significantly worse than usual due to COVID.
They and everyone else should also be grateful for the FSF.
NFT is no more and no less bullshit than modern art.
Cryptocurrencies are no more and no less bullshit than fiat currencies.
Metaverse is no more and no less bullshit than all commerce in the real world.

The difference is who controls it.

It is all about power transfer.
Ants dispose of ants that are cordyceps infected for their “social distancing”. The worst part is the political stances people make based on the logic of social insects.

Social distancing is such a fuzzy term, it is as clear as the word “thing”.
unfortunately you can still get covid or a variant of it. there is a small reduction in your chances which is better that nothing but the more we are learning about the virus and our vaccines we are still seeing a decent amount of deaths from those of us who have been vaccinated, my brother in law’s uncle died after he got his second shot, he was otherwise healthy. we don’t know if it was a coincidence but, still something to consider. especially with this report. it’s best for those of us who are comprised to still be very careful until we figure it all out or just have to accept it, which is sad but hoping for the best
Really? It’s pretty clear that a lot of people made up their mind and chose to get vaccinated. But that’s fine of course, it’s only a problem if they make up their mind and decide something else.
Very interesting - my co-worker reached out to you to see if one of our sites would work. It's a collection of analysis tools written in JS meant for the desktop web, but we can reconfigure it to work better with responsive viewports.

Would really like to get something like this as a proof of concept for our clients who just love mobile.
Whenever I read things like this, I think about Crypto AG.

Solid impenetrable encryption from a neutral and privacy obsessed country. All a careful front for the CIA.
The encryption was solid as far as I know but they the CIA had a back door.

If there was a backdoor into the system somehow, it would be perfect to have stories such as the above to recruit criminals or even foreign intelligence to adopt it.

As far as I know Signal is 100% legit and deliveres what they promise.
and I use it myself.

https://www.washingtonpost.com/graphics/2020/world/national-...

https://www.theguardian.com/us-news/2020/feb/11/crypto-ag-ci...
My 2 huge plants (ficus benjamina, 15 years old, grown from 1 tiny branch, and aglaonema, ~40 years old and survived one freezing): https://pbs.twimg.com/media/FC7tsGGWEAkInx1?format=jpg
I'd like to point out that this also means that his t-shirt has the logo pre-flipped. What an absolute madlad.
He clicked something below to trigger that. I think the pane he's using actually got moved, so potentially he has a couple lined up?
Not to mention that it’s hardly extraordinary for two doctors to have two different opinions on the same case.

What does that mean? That there are two conflicting absolute truths?
I'll take the chemical weapons, thanks.
How exactly is readability made up?
While part of Santa Barbara due to some weird zoning quirks, the majority of off-campus housing is actually in Isla Vista/Goleta. Santa Catalina already has 11 stories.
Copyright is a functionally eternal state-granted monopoly on data that's hard to produce. It's a monopoly on bits, numbers. Not only is it an utterly helpful notion, enforcing copyright in the 21st century helps us to protect our computing freedom.
These discussions remind me if 1995 when Microsoft tried to create it's own version of the Internet - luckily that failed, we still got Windiws and IE though. Lol

I'd imagine it will be similar with Facebooks strategy
That's not a likely scenario. They aren't trying to create a Camry that handles like a Porsche. They're trying to sell Camrys. The effects will be subtle and plausible. To the extent that it's discovered, there will be excuses. And even after it's discovered, it will continue, just like everyone today knows TV car ads aren't real, but they're still effective, because they tap into the right parts of our brains.
> Publishing kernel patches is one thing; publishing an entire operating system distribution where everything runs properly out-of-the-box with those patches enabled by default is quite another.

That's exactly my point. That's why I find it so annoying that these articles say the wrong thing.

> Neither grsecurity nor OpenBSD "invented" PaX/W^X. They were using pre-existing hardware features designed precisely for this type of capability,

The first version of PaX predate the page table no-execute bit in x86 hardware, and I believe (eventually) W^X didn't require it either. So no it was not a matter of merely starting to use existing hardware capability.

That's why it even was an invention in the first place.

Everything got vastly easier once the page-level execute bit was launched in hardware.

At the time, when OpenBSD was asked "why aren't you looking at what PaX did?", and they answered that "we don't care what others in the industry are doing". Which is a strange way to think you can create the best security.

So Linux patches: 2000.
OpenBSD: 2003.
Windows: 2004.

(not saying OpenBSD didn't do it better, because they don't care about binary compatability, making it easier)

If OpenBSD had "invented" it, then how could microsoft possibly have launched it only one year later?

Again, I do credit OpenBSD for being the first OS to do these things by default on an OS. But that is, as you said, is "quite another [thing]" from inventing it.
Uncertain. Likely nothing noticeable.

Only thing in the vein has been a better ability to plan, reason about in my head, and make use of visualization to reason about problems (and their solutions).
The smallest float you can do that still shows all the patterns is 5-bit (2-bit exponent). If you had only 1 bit for the exponent, you'd go straight from denormal to infinity.
If the updates were mandated at the time of sale:

You'll find a lot of people trapped in homes they cannot sell. The cost to update very old homes would far exceed what most people can spend out of pocket, and by the time they paid off the debt to do so, the codes may have changed again.

Also, older couples who have lived in one place many years and are now retired generally cannot take out lots of money. Instead of being able to sell and move to a senior community or nursing home, they would be stuck with a property they cannot maintain, compounding the problem.

Essentially, you would be hurting vulnerable people at the advantage of the young and wealthy.

If the updates were mandated as the code changed:

See all of the above, but now you're forcing people out of their homes even faster.
It doesn't matter, honestly. You still own it. Owning apartments is normal in more crowded areas - like tokyo. I'm pretty sure apartments greatly outnumber houses in most of Tokyo.

And sure, there is a difference, but it is only minor as we are still speaking of living spaces that you own instead of rent.
Capital improvements also had a bump up (but it maybe recede) - my fire insurance rider for “replacement cost + code updates” is now almost twice what it was a few years ago - reflecting the increase in building costs.
Not illegal everywhere, and not uncommon, either. I was a little late booking a trip to Stockholm the other day, and of the few remaining quality hotels, most rooms were sadly listed as "No windows".
Extra borrowing power means that more people can be slaves to the banks for a longer time. They realized how lucky they are and they exercised their freedom to be enslaved while also helping the prices to raise.

But prices, borrowing power are just relative. What matters, if you want to do a comparison, is how many houses or how large of a house could an average person buy in his productive adult life in 1965 compared with what can he afford now. So if the average person can buy in 40 years a larger home than in 1965, we are better. If not, not.
> I predict right now that by 2030, there will be successful metaverse companies, one of which might very well be Facebook. Another is Epic Games. Amazon and Microsoft are others who have the technical might to capitalize on this paradigm shift in how we work, play, and socialize.

Absolutely correct. I also predict this as well as the solution to the iPhone and its walled gardens [0]. Anyone who dislikes the Apple and Google 30% taxes will partner with Meta or the other metaverse-related companies.

I won't be surprised to see this challenge the iOS and Android (then soon Fuchsia) ecosystem of apps and games and to move to the metaverse-related companies accessed via some form of smart glassess.

They are first going to do this with games. Then the apps will follow and those apps will finally be built as PWAs.

It is a plan to challenge the iPhone and Apple's resistance to supporting PWAs on the App Store and Google's Play Store.

[0] https://news.ycombinator.com/item?id=29033404
Worm Joke Causes Science Twitter Flame War over Accusations of Sexism and Racism
Now let's say your name includes one of these weird 'Ä' characters...
Hmm. The movement is definitely mechanical, and it definitely sounds like he's writing on a hard surface.
farmville comes to mind. oh what fun times we live in
Well, Party balloons for one :)
I think you are taking the attempt too much seriously. The metaverse is nothing else than one of humanity’s oldest dreams: be God and create a world.

It goes all together with other humanity dreams like fly, eternal youth, read other’s minds, immortality, travel beyond the sky, trespass all frontiers/circumvent the world, telepathy, life without work or pain, etc.

They -have- to try, specially because they successfully achieved other large goals in their previous enterprises and now they feel they have to defeat new boundaries.
There’s a reason established landlord companies want nothing to do with single family homes. They’d much rather have large apartment buildings where then can more easily control and predict costs.
Maybe I've just been doing this too long but my first reaction was "Another one??"
CitriNET Demo Server with Citrine/Websocketd/PHP
Without the "concept of physical movement" how will "food" get to your "house"?
Yes, but Spark is almost unique.
I am an iOS and Android dev but I so agree that Safari needs better support for PWAs. App Store apps are dependant on the review teams approving your app (plus the additional delay in the review process of a day or so). Websites don't have this problem and anyone can access pretty much any website without any gatekeeper.
Successful with a huge asterisk, considering Fortnite was completely dead until they tacked on the Battlegrounds clone.
Only case in which codimension 2 is dimension 2. Codim 2 means “complement generates topology”. Dim2 is “can avoid points using an arc”. I guess this means a lot.
I think the brain is a skateboard. Or perhaps a cupholder.
Maybe no one wants sites wrapped in an app, but some of us do want to use the site through our web browser. So please keep on building web sites/web apps :)
Oh, are you? So the fact he is an asshole makes everything he did and thought “politics”? Is everything, any scientist does, which supports a world view you don’t like, “politics”?

Does this somehow invalidate the correction about the origins of ‘gender’’s popular meaning?

Have you read the article I linked? Do you still agree the distinction between sex and gender is all “politics”?
But proponents of censorship will argue that there is bad censorship and there is good censorship.
The meta verse should be BS, but it will be not.

Like it or not, It’s simply the next new/big thing and we better embrace it before it’s too late.

Funny thing, I’ve recently refused a job from one of the big players on the filed because they wouldn’t allow me to work from remote…
i know it’s sad, people will lash out others due to fear. i think it’s been extremely irresponsible of our leaders and honestly more so the media than anything. obviously not all media but especially some subs of reddit are laughing at people who have died. yeah most people can probably separate themselves from the information on reddit and not act on it, but there are plenty of people out there who aren’t as bright, who may take that information on reddit and use it to harm people thinking they are somehow justified in doing so. reports like this keep surfacing and it’s starting to show people that they really took the wrong approach about how they treated people. but my parents said stuff like this happened towards the gay community during the aids crisis. a lot of queer people were targeted more so during that time by people who justified their actions because of the toxic or misinformed rhetoric that was going on at the time.

i know it sounds cheesy but our words really do have power, we say things and they don’t always just get heard, they can be understood and acted upon or misunderstood and acted upon, good and bad. we’ve witnessed it before, sure the atmosphere was ripe during certain times, where a voice came forward and got people to march with them. good and bad. there’s a reason why oral traditions were and ancient text have talked about words having power. because it’s true. words have power.
I could see AR working if we get glasses that compare to your average or bit cumbersome safety glasses. That is you wear them, maybe not entirely love having them, but they do something useful for you. Overlay video, recipe, map. Provide information about surroundings. That is you are either working or maybe walking around and need to navigate, but don't want to keep your phone out all the time.

VR I just don't see getting there. It blocks your vision causing multiple problems, and technology is nowhere near where you would want to wear one for extended period of time.
Ask HN: Approaches to load balancing web sockets?
Might be simple, just trying to think of sane ways to do it. These are plain web sockets in Web JS to Node not using something like socket.io. It's user A to server to user B and vice versa.

There would be some kind of db involved in the event of it going down/can reconnect people by some ids.

My concern is do you keep say multiple domain options on the app (by env variables) or do you have a single url you hit (no?) and that branches off to different instances.

Scale is small now as in 10/100s of users, performance is not like a video game but still real time/more than text chat. The data rate is still low, mostly transferring meta data.
Show HN: Interprether – Real time feed of human-readable Ethereum transactions
Real world is like that, you can “code” manipulate the world. However there is a limit on some extent and in such worlds there will be other limits like a consensual physics rule on servers entry, like “local laws”. Rather than LUA think on declarative contracts that limit your crafting based on agreed parameters.
I have a much younger cousin who's in their teens. Teens of today prefer text messaging because they don't have to show their face. Even when my cousins video chat they don't like to show their face and will aim the camera in other directions despite being in video chat.
Imagine what has to be going on in your mind that you believe turning non-housing into housing will gentrify something.
> It would have been a better strategy if, at some point in the last decade, the powers that be had stopped printing money and let some bankers go broke.

If you are talking about 2008's TARP, the US gov actually turned a profit from that as the bailout was mostly in the form of loans (with interest) and investment (the US gov now own shares in your company).

https://projects.propublica.org/bailout/
Has anyone ever done any studies on the effects of long, daily exposure of the eyes to a vr headset’s optics and screen to the human eye?
Some people say it doesn't work for them in Firefox or Chrome. Surprisingly it works for me even in Tor browser (even in safest mode). Although it seems that its method to distinguish between Tor browser and Firefox fails and still assumes I'm using Firefox.
I hate fancy designed sites that take forever to load, or need to be refreshed to work. If you’re really calling everyone an idiot who doesn’t like your bloated site design, re-examine why is it genius to have bloated sites like yours?
Prague's Brutalist Buildings
Or Philips
Quick QR Code Generator – Generate QR Codes in Less Than 1
The lane closure (or rather: repurposing) now provides fast access for emergency vehicles. Given that most of the roads they’ve made these changes on are the direct route to the university hospital it’s a good outcome.
I'm sorry, but this is sheer silliness. A "country" doesn't "decide" to make an asset class appreciate or depreciate. It's always been driven by supply and demand.

If the population of this country stopped growing and started shrinking, a lot of real estate would be freed up. Demand for housing in the densest cities would drop, and it would be cheaper to live.

Real estate prices have gone up for the last hundred years because there are more people. This is why it has been an effective and predictable model for businesses like car dealerships to always locate on the outskirts of cities and wait for the city to come to them, sell the land and move further out.

There isn't anything nefarious or even strange about it. It's a natural result of population growth and increasing demand that consistently (so far) outpaces supply. Nor is it inevitable; look at China. Tons of empty apartments, cheap bordering on free to live in. That's what happens when supply outstrips demand.
Decimal floats are also available in gcc

https://gcc.gnu.org/onlinedocs/gcc/Decimal-Float.html