skysight-inc/HackerNews huggingface dataset:
> This is completely consistent with the patient never telling the doctor that, to their surprise, after waiting months the SSRI side effects never go away.

That's true, that could certainly happen. I'm more skeptical about the rate at which it happens -- but also, if it is happening, presumably a patient will eventually go back to someone in the medical system and mention it. Whether they connect the dots is a question, but one which can be studied.

> I made a pretty small claim, that your psychiatrist may (not did have, may have) had patients with a condition they didn't discuss with her, that only became known to the patient after treatment had concluded. If you think a minor claim like that requires "surveys" or data, believe what you want, I don't know what to tell you.

The claim that my psychiatrist might have done something or not isn't the claim I want data for. The claim I want data for is "I'm also correct that many patients who have gone off the drug to see if the sexual dysfunction stops will probably no longer be making appointments with the psychiatrist. What would be the point? If they want to talk to someone that's what therapists are for."

That's not an anecdote, that's a pretty bold claim.

> The article this thread links to indicates there is no cure, so any patient who has done research would know discussing it with a psychiatrist would be useless.

I don't think people think about things that way necessarily. I wouldn't read an article and conclude I shouldn't talk to my doctor because the article suggests the doctor can't help, because I don't necessarily put that much faith in a single article. And doctors will frequently ask these sorts of questions, so even if I had read the article, I don't think I'd lie about it to them.

In general, I think you are making a number of assumptions about how people - doctors, insurers, pharma companies, and patients - behave that aren't necessarily borne out in reality. If your assumptions are all correct, your conclusions are reasonable, but I am not sure they're correct.
Still better than throwing away a significant percentage of the world total power output just to compute some useless hashes if you ask me..
I doubt it. The earth is like a bag of jello and if you tried to thrust it = problems even at 1/1000G, and your reaction mass could not travel through the atmosphere or it would entrain a huge volume of air, and, remember, this jet would have to exceed the escape velocity by some margin as 7 miles/second would be taken from it on it's upwards path. Lets say you make a tower above the atmosphere - say 100Km high - what you gonna build it from? The toughest known materials would slump into a puddle far below 100 Km. Even a step pyramid would not work as it would cover a huge area and cost the planetary GNP 100 or more times over.
It is OK as gedanken ware...
Tell that to your (non-existent) kids
This is a tangent, but has there been any ideas around making a stroke-based encoding of Japanese/Chinese writing systems?
“Use it or lose it” applies in evolution, because of energy usage, but also because of complexity. More features means more things to go wrong, more options for cancers, etc.
One of the direct consequences of UBI is inflation IMO. Of course things are going to be more expensive if we give everyone money. That doesn't mean poor people won't be better off. If your food costs 20% more but you have 200% the money, that's a good thing. UBI is like printing money, yes you have inflation, but the money is still useful.

Inflation won't eat the whole UBI (probably), because there's still supply and demande that other revenue generate. E.g. if I pay 20% of my income for food and UBI doesn't affect my income much, I won't be inclined to increase my spending on food by a big %.
All of this assumes that other games will "play by the rules", in the sense that they won't let you use an item that you don't own. If I can see the resource (and in all current models, the content of the signed media/document an NFT authorizes is public) then I can use myself if my client is so configured. Most games give value to loot by forced scarcity, NFTs don't implicitly enable this at all.
I'm not sure that's a hard and fast correlation. We have indicators that suggest that housing prices are increasing because of equity funds literally engaging in rent seeking behavior by buying of housing stock and turning into rental property.
Probably shouldn't be made an official thing, but it'd be funny to do this on all the various minor manually-adminned sites out there.
I'd imagine it's not that hard to tie a "Meta" user back to a "Facebook" user. Seems like it's all just for PR.
FDA pressured loperamide manufacturers to stop selling large quantity bottles because people thought eating a whole bottle was a good idea.

Problem: taking massive amounts of loperamide to get an opiate effect is a myth

Of course, the manufacturers were all happy to fall in line anyway and dramatically raise per-tablet prices (and packaging!)

Except one manufacturer.

Several years ago, I bought a 200-ct bottle for US$9 shipped to Canada. Now it's US$36.
As the article says, it depends.
> Vyvanse is metabolized to d-amphetamine in your blood cells

Do you have any more information about this? Can't find it on google - would be very interesting if its true but I'm a bit skeptical - I've never heard about blood cells being a primary site of drug metabolism.

A search turned up:

> "Lisdexamfetamine dimesylate is converted to dextoamphetamine and L- lysine, which is believed to occur by first-pass intestinal and/or hepatic metabolism."

(https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/02...)

According to this, sounds like its mostly intestines and liver, which is much more typical for drug metabolisms.
It sounds like there's a suggestion that cultures where alcohol has no notable effect on overall violence. I'm curious what culture that is.
All of this talk about supply chain issues are totally missing the point in my opinion. So many articles (and tweet chains I guess) have been written about supply chain issues, yet every one of them seems to ignore the elephant in the room which is demand for goods vs services. Over the course of the pandemic there was a staggering re-balancing of consumer spending [0] from services to goods, to which supply chains have not caught up.

If the spending doesn't re-balance again as restrictions are lifted this is not a temporary supply chain issue caused by just-in-time methodology, it's just the new normal.

[0] https://apps.bea.gov/iTable/iTable.cfm?ReqID=19&step=2#reqid...

EDIT: That link is broken, should have been this https://apps.bea.gov/iTable/iTable.cfm?reqid=19&step=3&isuri...
To me it's almost as impressive that pv does not become the bottleneck.
You'll get docked points from the typography nerd for displaying "fizz" instead of "ﬁzz"
It's UB for positive integers, so the compiler can assume it never happens. It's correct for negative integers, so the compiler just optimizes it for negative integers and ignores the positive ones - in this case with the end result that it works for positive integers as well.

If the argument is changed to unsigned int then it seems to be correct and portable because the C standard[1] requires UINT_MAX to be of the form 2^n - 1 (which makes it wrap from odd to even when overflowing).

So the one with signed argument is UB for positive integers but happens to work by accident (but the nasal demons may still lurk just around the corner, e.g. the compiler may also assume that it's never called with a positive argument which may affect the compilation of callers). The one with unsigned argument is correct because unsigned overflow is well-defined to wrap around to zero, combined with the restrictions on max unsigned int.

[1]: From C17 6.2.6.2:

For unsigned integer types other than unsigned char, the bits of the object representation shall be divided into two groups: value bits and padding bits (there need not be any of the latter). If there are N value bits, each bit shall represent a different power of 2 between 1 and 2*(N-1), so that objects of that type shall be capable of representing values from 0 to 2*(N-1) using a pure binary representation; this shall be known as the value representation.
Nintendo offsets lackluster hardware with exceptional games. The end result is Nintendo rarely becomes the outright leader in any hardware segment. I agree they are successful, but I can't recall when they last "blew away the market"
Whats the benefit of this over paredit? I already use such a seemingly small subset of it, is this just a new set of bindings?
It's beneficial to lower the brain's calorie intake it if it results in higher reproductive fitness. But like GP said, we have plenty of calories, more than we've had compared to the entire history of humanity. So it doesn't naturally follow that lower calorie brains are higher fitness in 2021.
We keep our canals reasonably clean; especially if you're close to one of the inlets of clean water the risks are low from what I understand. In the summer you have to watch out for algae etc. But we also keep track of those in official swim water around the canals. And finally I think the risks of swimming in a crowded small official swimming lake can be pretty high as well. But yeah, I'd still think twice before going swimming in a canal and I'd try to keep the water out of my mouth etc.
You're off on the first one. There was a lot of discussion:

https://news.ycombinator.com/item?id=27319457 - May 2021 (238 comments)

https://news.ycombinator.com/item?id=26898266 - April 2021 (195 comments)

Not only did we not censor that, I recall holding back on moderating it. We moderate HN less, not more, when YC or a YC-funded startup is involved (https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...).

You're right about the second case - we moderated that as not on-topic for HN.
> border adjustments.

Don't we already have tariffs on China? I am a little hazy as to whether Trump's were repealed or not. IIRC, the political opposition was from all those companies manufacturing there -- e.g. Apple, Tesla, etc.

It's certainly something I would support more of, but the problem here is that targeting tariffs to specific countries has shown to be ineffective, as there are global supply chains, so goods are shipped from China to Vietnam to Taiwan to some other place and finally to the U.S. So it's not simple as to say impose a tariff just on Chinese goods coming into America.

IIRC, after Trump's China tariffs were announced, Vietnam suddenly became a huge exporter of the most targeted items, and it was pretty clear they were just relabelling items from China as "made in Vietnam".

This is covered in this WSJ story:
https://www.wsj.com/articles/american-tariffs-on-china-are-b...

Global trade and capital flows are not really bilateral. It is very much a US vs Rest-Of-World, or at best US versus Regions.

So one option to reduce cheating might be to segmenting the world into zones:

US - Canada
US - Latin America (add everything south of the border)
US - Europe
US - Asia (throw Africa here, due to China/Africa ties)
US - Russia/Middle East/North Africa

Then apply tariffs just based on the zones, rather than specific countries. Of course I am speculating, but I do know that country-specific tariffs are very, very leaky, and even in this system, there is a lot of incentive for China to pay some nation in North Africa or Latin America to import stuff and put its label on it, then export to the U.S. For a big tariff, it would certainly be worth it. That's why I prefer interventions in the capital account rather than in the current account. The US has much better control over the global dollar system than over the global trade system.

> probably 70+% of the global economy

US + EU GDP is 36 Trillion, Global Economy is 76 Trillion, so about 40% of Global GDP.

But probably US + EU is one party to a good 70% of Global Trade. Not sure for how much longer.

https://data.worldbank.org/indicator/NY.GDP.MKTP.CD?location...

https://www.worldometers.info/gdp/
Higher price on lower end housing, but that incentivises building more lower end housing (since higher end housing is more elastic and won't have as big of a markup).

EDIT: actually, thinking more about this I don't think lower end housing will see such an increase, since most people already have a home. You'll certainly see a rise in price of lower end housing, but it won't offset UBI, since I doubt people will just take ubi to put it into their housing
Definitely, no argument here. I meant Intel 7 is the previous Intel's 10nm. It is confusing in my parent thread where the commenter uses Intel 7nm, which is not a thing in any case.

Of course, this is probably all intentional from Intel's point of view (letting people say "Intel 7nm" rather than "Intel 7").
R&D in 20 small companies is less effective than in 3 big ones due to less diverse teams and more inefficient double spending, e.g. twenty $5M microscopes utilized at 15% versus three at 90%.
We should be so fortunate. Unfortunately, the scum infesting Kiwi Farms will always find others to bully and other platforms on which to do so unless they in turn are doxxed and subjected to the abuse they heap on others.
Now I'm kinda curious to see how much faster you could go on an M1 Max with the GPU generating the data. Once his solution gets to the point of being a bytecode interpreter, it's trivially paralellizable and the M1 has _fantastic_ memory bandwidth. Does anyone know if the implementation of pv or /dev/null actually requires loading the data into CPU cache?
Yeah my brain thought “cancer causing” drugs. I was thinking the dyes and such they use must have been linked to cancer. Glad to see I misunderstood.
I think back to this essay every year and have done so for years. Worth re-reading. I learned the King James Ecclesiastes verse because of it.
> neither pfSense nor OPNsense support NPTv6 to a dynamic prefix.

If you wish to keep track, I believe this is where pfSense is working on this:

* https://redmine.pfsense.org/issues/4881
> When you take the normal dose (10-30mg) it can cause some euphoria but for the most part it helps you focus, gives energy (makes you more happy, talkative.) But when it is abused (60+mg) it can cause serious psychosis with all kinds of mental side effects.

Background: I'm prescribed 20mg/day of extended release Adderall, via a legitimate ADHD diagnosis. If we take the article's "meth is 2x as potent as Adderall" statement at face value, that would mean I'm taking 10mg equivalent of meth per day.

Now, since part of the reason I take this medication is to remember to take my medication (a joke, yes, but not without its kernel of truth!), I've accidentally double dosed myself before. I've also done the same previously when I was prescribed instant release Adderall. In either case, I've never experienced anything like a euphoric high, but I have experienced the kind of "uselessly driven"/tweaker sort of side of it. And, let me tell you, I do not like it when that happens. Although I'm in no hurry to find out, I honestly find it hard to imagine what the high must actually be like in order for people to voluntarily subject themselves to the negative effects of this drug. And, I don't even exceed the therapeutic range when this happens!

I wish there was some way to actually understand why people abuse meth without actually smoking meth myself, which I'm unwilling to do, for obvious reasons.
> supporting hate

That is a bold, unfounded, unappreciated accusation. I do not support hate. I support gut feelings borne in truth. I will continue to not give free car rides to homeless people and to offer to help carry groceries out to the cars of little old ladies in front of me in line at the grocery store - because yes, stereotypically, the homeless are more likely to be drug addicts, mentally unstable, and have a criminal record, and little old ladies are more likely to need assistance carrying things. I don’t hate homeless people nor do I hate little old ladies or consider them inferior. But please, feel free hire someone with face tattoos to be your child’s bus driver in the interest of ignoring all prejudice at all costs. The rest of us will continue to make decisions using common sense, regardless of what Twitter has to say about the matter.

> The (general) lack of prejudice where I live works wonderfully; the bigotry - almost always from outsiders who have no experience with the people they hate - is the only problem. If they all went away, we'd have one less problem.

Could it be you’re wrongly conflating prejudice with hate? Don’t discount peoples’ life experiences either. Furthermore, your example is anecdotal. There’s a plethora of widespread non-anecdotal data to back up “prejudice” being accurate and helping people make wiser decisions.
Beneficial how? Reduction in calories? We tend to have diseases of excess calories in the developed world now. If anything, the greater brain metabolism may actually help by burning some of those excess calories off…
Yep. I suspect most people here could write a working fizzbuzz on a whiteboard in language of choice in under 5 mins during a job interview.

Sure your Python/JavaScript/Haskell/Rust version builds on a bunch of abstractions, but it’ll run on just about anything, and …

“I've spent months working on this program”

That’s not what your boss wants to hear.
Contemporary social policy as a whole appears to be a cycle of reaction and hysteria. There's very little substance to this process, in the form of empiricism or evidenced-based feedback. This cycle appears to be a by-product of our modern information mediums. I think that generations prior to ours (I too am approaching 40) weren't as vulnerable to the whims of society's most easily frightened and manipulated members. I think the only solution is to vote with our feet, and leave the hysterics behind. I suspect this process is well underway, now that the more educated members of society have the ability to work from home.
The Inevitable Rivalry
I thought the conventional wisdom was to avoid the STL if you need consistent performance across platforms, because they all have different pitfalls. Things might be different with libc++, now, though, since you can use it in most cases.
One problem with relying on toothpaste, is that for many children, the parents are not good at parenting and don't provide tooth brushes/ toothpaste or enforce regular tooth brushing

(and from experience, my teens/twenty somethings are somewhat hit and miss in this area as well since they moved out)

Putting it in the water supply ensures most people will at least get some fluoride.

One big problem not covered in the article, is this leads to fluorosis - my eldest has permanently stained teeth due to me not making him spit out his tooth paste after brushing when he was a toddler combined with the fluoride he was getting from town supply water.
Don't blame the users. Blame the choices that Facebook has made. They WANT the toxicity, it keeps people's eyes on their phone.
I think the kind of optimization here is beyond that which people used to do. AVX didn't exist when it was common to write assembly.
Kick out Netflix.
MAGA

Tell your Silicon Valley friends that you work at MAGA
MAGMA (Microsoft, Apple, Google, Meta, Amazon).

I've never understood why Netflix was equated with the bigger companies. It's market cap is $300B the others (excluding Facebook) are all above $1T, and Facebook/Meta has a chance of breaking the $1T in the next year.
Its foolish to assume that the coast line is going to stay where its most convenient for housing. Its like building a tree house then complaining that the tree keeps growing despite the uselessness of further growth.
My point was that firing these people isn't going to be worth it. Delta is here to stay despite it all.

At some point you need to look past the medical data and look at the impact these divisive and discriminatory policies will have on the unvaccinated, which is roughly at ~15% of a countries population.

Are you happy to strip these people from their human rights?

Are you happy to discriminate against 15% of the population? Rejecting them from going shopping or other basic tasks?

Are you happy to push these people further into an ideological war with the mainstream?

What are the costs when governments like Australia deny their own citizens the right to move interstate or internationally, on a whim?

Are you happy to have a global vaccine passport, which will restrict your freedoms dramatically and automatically as soon as you decide against your next booster shot?

What are the costs when trust is eroded within society?

I can just tell you this right now: its simply not worth it.
The cost of some shortages is measured in lives. With such shortages, preventing the shortage is better than mitigating the shortage. Mitigating the shortage is in turn better than not mitigating the shortage.

A buffer gives us time. That time can be used to save lives.

A buffer absorbs a short term disruption in a supplier which prevents the shortage. A buffer gives time to look for another supplier in a long term disruption. A buffer delays a shortage when no other supplier is feasible.
Soviet democracy was never a good faith attempt. I mean, Bolsheviks have forcibly disbanded an elected Constituent Assembly after it deliberated for 13 whole hours (during which it became clear that they don't have majority support there). But it doesn't mean that the fundamental principles of council democracy as they advertised it don't work.

I would suggest looking at libertarian left instead. https://en.wikipedia.org/wiki/Communalism, in particular.
I think they announced that they're doing exactly that (or at least working on it).
When I saw this I did wonder how much faster I could do it in hardware, but similarly I expect the bottleneck would be outputting it in a fashion that would be considered fair to be compared to software implementations (eg outputting readable text on a screen).

Regardless, I very much enjoyed your DVD screensaver-esque output.
So I might have a less optimistic analysis of the plus/minus of the internet, but more importantly, I think it was created under very different circumstances, in it's birth-years, by actors with different interests, values, and goals -- than the "metaverse" will be. The metaverse will be much worse.
> The idea of using clean energy to produce hydrogen to then ship it off with a crude oil powered tanker is just .. beyond me.

In that case it might blow your mind the fact that natural gas is shipped in crude oil powered tankers.

https://en.wikipedia.org/wiki/LNG_carrier