skysight-inc/HackerNews huggingface dataset:
> It certainly made me think there was an earlier 'sterilizing' vaccine, which is why I asked for clarification of what was meant.

The issue is not whether any previous vaccines for covid or any other infectious disease have been "leaky" or not. It is that vaccination of the entire human population of the planet against such a disease using a "leaky" vaccine has never been tried before and we don't know what effect this will have on the virus. We have already seen different strains bypassing protections conferred by the vaccine resulting in the introduction of booster doses and even mixing-and-matching of multiple vaccines.

Most vaccines often hit the "good enough" threshold and are pressed into service. In the case of covid, while the vaccines currently in service are "leaky," the intranasal varieties being trialed seem to have superior outcomes and, in animal studies at least, "almost entirely prevented SARS-CoV-2 infection in both the upper and lower respiratory tracts."[1]

> In a recent animal study involving human ACE transgenic mice, an intramuscular dose of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S) induced robust systemic humoral and cell-mediated immune responses and protected against lung infection and pathology but failed to confer sterilizing immunity. In contrast, a single intranasal dose of the same vaccine-induced high levels of NAbs, promotes systemic and mucosal immunoglobulin A (IgA) and T cell responses, and almost entirely prevented SARS-CoV-2 infection in both the upper and lower respiratory tracts. Considering this and the fact that even natural SARS-CoV-2 infection induces mucosal IgA response, it would have been prudent had more vaccine manufacturers explored this route. This is especially crucial when a vaccine is being considered as an important strategy to halt the pandemic. Thus, the authors believe that it is unfortunate that none of the candidates that are currently under clinical trials is exploring the nasal route of vaccination, although it is recognized that many types of vaccines are intrinsically nonimmunogenic by the intranasal route.

Maybe they should have tried this first.

> it is not a common term in the research literature.

No one reads research literature because no one, other than those with training in the relevant fields, understands that literature. People argue and make assumptions based on conceptual similarity or parity. And it is perfectly fine to do that.

> "non-sterilizing" of medical instruments might mean

I have lived through times when you had to boil needles and glass syringes before reusing them to prevent pathogens and other biological material from entering the body through unclean or reused needles and syringes. This process is "sterilization." The idea is to eliminate life from the instruments, not add it.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754925/
Here's my worry with Intel - even if they get their fab to be competitive, they're still working against a market that's changing against them. The big players are all working on their own chips now and are pursuing SoC designs, rather than independent processors, and ARM seems to be the future trend.

Amazon has their own chips for their servers, Microsoft announced they're working on their own chips, Google just released their first consumer chip this week, and the M1 is crushing the competition.

I just don't see Intel succeeding with all of these things stacked against them. I hope they prove me wrong as more competition in the space is always good, but as it stands I'm not optimistic for their future.
I mean it’s an implicit negotiation of sorts. If you can routinely leave work early and not get penalized for it, you’ve basically “negotiated” that arrangement.

This all comes back to the fact that everyone should be protective of their time. I’m single but regularly run errands, exercise, go grocery shopping etc in the “middle of the workday”. I get my work done. Nobody complains.

It’s just a matter of knowing and recognizing your own value.
I have tried the Stafford gambit against real people and i have found that unless people fall for the trap it is a very weak play for black. I keep having to make dumb moves hoping for the other player to fall into the trap.
It works for me with GNOME and Firefox 93, your colleague may have to update. Not Google Meet but I did it successfully with Jitsi.

But I am referring specifically to the developer experience I had with the API, not the progress of any given application in implementing this API.
With increasing hostility towards education, we may also regress.
I just say Reddit.
> Didn't Intel sell their farm? To Samsung wasn't it?

no

>The only way to extract any of the value still extant inside Intel

Intel is still a massive company with fabs in a world with chip shortages. If your car chips that aren't available such that they're shutting down car factories, are then made on 14nm+++ no one should be concerned.

Intel has plenty of runway to come back to competitiveness.
I live in PNW and have lots of friends working at Microsoft. Despite the whole "One Microsoft" drumbeat, they're pretty much still the MS of old with little tribal infighting trumping customers' needs.

Windows in particular feels like a captain-less ship with no one overseeing the big picture and every little group pushing their own little shitty features to prove their raison d'etre and their budgets and promotions.

It's pretty sad really; they used to have a monthly "town hall" where the leadership team was answering real (sometimes tough) questions from employees, but they replaced those with fake / pre-scripted casts with softball "Q&A" meant to introduce a team or a feature instead of answering an employee's concerns; meanwhile, real employee feedback and questions are left to fester in the Yammer echo chamber.

Lots of people leaving core products, but hard to say if that's MS-specific or the industry-wide recent trend. I'm told managers recently did a "stay interview" asking ICs really weird questions about why you're staying at MS, why you'd be leaving, etc. so it's likely the attrition problem is pretty bad.
I get a certain (artistic?) satisfaction in bringing order out of natural disorder. Trimmed bushes, groomed/edged lawn, mulched beds - can't all be a throwback to a bygone era, can it?
> But my personal aesthetic compass swings back and still chafes at the "non-functional" functional part.

My problem is not really that they are not functional. It’s that they do not even try. It’s like they insult my intelligence by being ostensibly worse than useless. These 20 cm wide things are a joke, they’re not even trying. They could have least have the right shape, size, and an overall plausible appearance.

It’s also really ugly. Part of the appeal of the real thing is the harmonious shapes and proportions with the windows they are supposed to protect. Thin bands on either sides of a large window just looks absolutely terrible.
Relevant Tom Scott, How do you make something last 1000 years: https://youtu.be/uhtUYzubRHU

Spoiler: set up a trust.
It sure is, if you adjust for that at work. If you don't, you're expecting parents to work (at least) two jobs.
I literally negotiated for the flexibility of my working conditions. Had to renegotiate when the pandemic hit.

Parents needing such negotiations may be a "hidden cost" that y'all aren't considering. Also, parenting is a ton of work so when I kick off the paid job, I'm still working 'til 9 most nights.
How do you calculate "net effects" when dealing with millions of people suffering in the near term? What does it take to balance that and end up with a net positive?
That may be true in the US today, but other countries have voting systems that are easier to understand and more transparent.

Let's take a reasonable threat model. The society is heavily fractured. Not in an inconsequential way as in the US today, but more like Europe between the world wars. Communism and fascism were mainstream, and there was a credible threat of a civil war. (Not to mention a fair number of actual civil wars.)

Consider an average voter who does not trust the election authorities or the companies providing hardware and software for the elections. Maybe they are a communist who assumes that every major tech company is on the other side and actively trying to tamper with the elections. If the elections are actually run in a (mostly) fair manner, will that person trust the results?

That happened many times in the early 20th century Europe. People who had no reason to trust the elections still believed in the legitimacy of the results, which probably prevented civil wars.
Uh, what? At the very least there's linux, macOS (mach), bsd, and now windows subsystem for linux.
> It sounds like you are saying that Vikings might not have been in America before Columbus.

Please don't use the straw man fallacy with me. Is very obvious that this is not what I'm saying.
Fastmail is on the expensive side by my standards, and has occasional service interruptions like this, but I'm basically happy with them and would go with them again. A much cheaper option is mxroute.com (watch for a black friday promo) but that is more DIY and is a smaller operation. In all cases, if you want a long term email address, use your own domain (doing that costs extra in Fastmail's case) rather than one belonging to the host. That lets you switch hosts if something makes you want to do that.
Examples of what in particular?
They’re not suckers if they get raises and/or promotions. Then they are being fairly compensated for their time and commitment, and have no reason to complain, right? It’s only a problem if there’s no reward for all that extra work.
> I run into this crap all the time to the point that people who claim it isn't a problem I know have to be lying.

I don't think that's right.

Just because someone denies a problem exists—a problem that you know for a fact, with 100% certainty exists—doesn't mean they're lying.

It may mean you know they are wrong, but wrong != lying, and it's a good thing to keep in mind.

If you have external reasons to believe that the person you're talking to should or does know better, then it's fair to say they are lying.

But, in general, if you accuse someone who is simply wrong to be lying, you're going to immediately shut down any productive conversation that you could otherwise have.
I think divorce statistics are not related to age of pairing off, which if anything was younger farther in the past than it was even a generation or two ago. Divorce is simply not the social stigma that it used to be, and it's easier to get so it happens more now. Rather than working through their problems, people think it seems easier to just split up.
Devin Townsend does this too
> EDIT: It's important to note that mild inflation is a good thing. It spurs people to buy now rather than later. If inflation was zero for a hypothetical country, why buy a house today if you know the house would be the same price 10 years from now?

This argument in favour of inflation always baffles me .. yeah, maybe people weigh different reasons for/against buying something like a house now or rather later ... but I'm rather sceptic that regular people who'd buy a house to live in it (who could afford to buy it right now) would have a relevant tendency to wait another 10 years because there's almost no inflation.
For entities such as real estate investors the inflation aspect is obviously a lot more relevant, yes. But for regular people, most buying decisions are probably dominated by the aspect of when they need the thing, not by the speculation of whether the thing they could use right now might still cost the same in the future.

Besides that, the notion of spurring people to buy now rather than later is IMO a bit outdated. Buying less now and shifting consumption into the (hopefully less carbon footprinty) future might be one of the most important levers to push, to get humanity out of the climate catastrophe trap.
Might just be the argument in favour of deflation ... let's hear it in 10 years from now.

I'm also curious what all these modern monetary advocates will bring up when - contrary to their predictions - inflation doesn't just conveniently level off to an acceptable 2 per cent in the next 18 months.
I've seen them up north and I think they're a good fit there.

I suspect (not sure) that they aren't as strong as single piece shutters and here on the Gulf coast it might make a difference.

Noting here that I prefer typical shutters over rolldown protection. Hinged shutters are great to reduce light and the winds that rolldown are good for can lift off (gable strapped) roofs.
> If I dispute my vote record, I can challenge it using my secret information and quickly expose that my votes were tampered with.

How can a legitimate challenge be distinguished from one by malicious actors who want to nullify the election even though their votes were counted correctly?
I've been saying this for 20 years or more. Glad to find I'm not alone.
I've always been of the opinion that to allow third party content to be embedded in an HTML page was a mistake. URLS within a page that embed content should have been relative to the page itself, never to another host. Of course the current one is much more powerful but both archiving, bitrot and security would have been a lot better served if it all got served from the same host.
This is why I got into vinyl; I love the art. I have streaming available in every room via Alexa devices but I do enjoy the experience of vinyl when I’m being intentional about my music listening.

Between the art and the tactile experience vinyl requires, I like it for active vs passive listening.
I've got a ~10 year old audi with the HDD as well as Dual SD Card Readers. When i first bought it I thought that was absurd, but now that i have it loaded up with multiple 128GB SD cards its actually a pretty good feature.
Brick needs no painting. If you’re choosing a brick finish to save on exterior maintenance, then the brick is functional, even if not structural.
Scaling Elasticsearch Percolation for Government Data
How is audit implssible? Anonymous ballots are only hide who specific person voted for. All other information is possible to verify.

Electoral roll exist, counting of people voted vs total number of ballots per area is possible, etc. Exit polls also exist.

Yeah US have it's thing with vote-by-mail especially due to covid, but before that most of important data points were easy to audit.
>I'm thinking of trying to stand up my own server on my own domain and see if I can get a good deliverability established.

I've been doing that for decades.

I had some deliverability issues back in the early aughts, but I haven't had issues for many years.

Over the past decade or so, SPF/DKIM/DMARC and not running an open relay (not that I ever did that) has kept deliverability very good for me.

That said, none of the IP addresses I've used are on consumer ISP ranges. That may have an impact too.
Well, think of it this way: all cuts of meat have varying degrees of meat, fat, and gristle. The meat, properly cooked, adds texture and some flavour; the fat carries immense flavour but can overwhelm with grease; the gristle is mostly crap: no flavour, gets in your teeth, chewy, unpleasant, best discarded or ground into sausage.

Broadly speaking. Some meat is so lean (bison, e.g.) that is must be cooked rare lest it become as dusty as the rest of Utah (the best bison I ever had was this fantastic place in southern Utah, hence the reference) and some meat is so fatty or gristly it must be slow cooked or braised or otherwise managed.

And consider that how tough is a cut depends on its use: various fowl favour standing on one leg so the other is ceteris paribus more tender; cf also the reference above to the front legs of red deer.

So “shitty meat” basically says “this animal did not lay about on fluffy cushions but scrambled for a living, except for this little bit here”.

Some people rave over tenderloin aka filet mignon. I love it, if properly larded and cooked. Otherwise, I much prefer rib eye: juicier, more flavourful, even if a little gristlier.

When I’m hungry, I don’t much care. When I have time and/or spare cash, a good starting piece well prepared is a joy.
> If Trump was re-elected tomorrow, do you want him to have these same powers?

Uh... what powers? There's no government action at work here. We're talking about the refusal of a bunch of Mastodon services to federate with Gab. I wouldn't expect that to change at all under a different administration, precisely because the first amendment severely constrains the government's ability to regulate speech. Trump can't make Mastodon clients carry Gab any more than Biden can force them to ban it, and for exactly the same reason.

> The Hunter Biden laptop story was censored and now it's been confirmed.

This one I thought was hilarious. That story was covered full time for like six weeks on the most watched news network in the country! "Censored", pfft.
So you're saying:

1. You need more range than your current car has to deal with these unexpected situations easily instead of luckily.

2. Balkanized charging infrastructure is brain dead. You need Tesla to switch to CCS in North America (like all other EV manufacturers have already done) and you need Telsa's chargers to charge all brands of EV (like all other charging networks already do).

The good news is Tesla will supposedly open their chargers to other brands soon. They can go ahead and put two ports on the chargers like they already did in Europe:

https://www.theverge.com/2021/7/28/22596337/tesla-supercharg...

https://insideevs.com/news/343728/most-tesla-superchargers-n...

The next step is for Tesla switch to CCS on the North American cars, also like they already did in Europe.
This is a great answer -- as with many humans problems across large timespans, this is solved by an institution, not an individual.
She wrote about things everyone writes about, but she put them in contexts that other people ignored.

That's why she's still relevant. It's not just that a thing happened and what the author thinks about the prevailing opinion of why that thing happened, but what was the historical, social, cultural context that led to it? That sort of thing she had a talent for explaining, without worrying about who she offended the ideology of in the process, as the article states.
In 500 years the internet will not be here.

Democracy will die.

We will probally be indentured servants to China.

Why will the internet not be around?

Public unrest. The wealthy will take away all forms of communication. The risk of unrest will be too great.

Underground newspapers will be circulated, but reading/possessing them will be a felony. All books will be burned.

The wealthy will be living in protected pods.

We will be living like the actors in Soylent Green.
Gödel, Escher, Bach (GEB)
Your past tense usage of the word 'hate' made me think your story was going in a very different direction.
Usually I don't think it's necessary. My yes/no questions are something like "Okay, so we need to put some more info into that file since that's what exported to the billing database, is that correct?". When I don't know something, I try yes/no questions at first. If I get "yes", then it's resolved. If I get a no, I will ask open-ended questions to explore the subect. Once I think I have a correct mental model ready, I will ask yes/no questions to validate it. If I get a no, then it's the cycle again.

For the "Is it raining outside", I honestly don't know anyone that would just tell me "no" when there's hail outside. For the "Do you like Vi or Emacs or something else?", it would be "What text editor/IDE do you use? Why?". "Do you like Vi or Emacs" by itself is not a yes/no question, it's a "what box are you in" question. For "Do you want to hang out for a coffee or something else?", that would be something like "Do you want to hang out at <TIME>?".

An important part for me is that in yes/no questions, no are supposed to be the exception. In my mind, when I ask them, it's not a 50/50 chance. It's more of a 80/20. If it was a 50/50 chance, that means my mental model is not precise enough.
The problem is that if someone asks "man, we really need to get X finished today; Jake needs to pick up his kids, would you mind?" it's pretty darn hard to say "no" unless you actually have a good reason not to.

You can call them "suckers" if you will, or you can call them "nice people forced in a situations where all options suck in some way".

Some employers are better in managing this than others. I've been at one small company where I was just a bit too often the "go to guy" because I don't want to be the asshole causing my coworkers to miss out on family time; or that's how it felt anyway if I had said "no".

Some employers will consciously emotionally blackmail employees like this (although it wasn't conscious in my case).
This is the best HN comment I've seen in a while, ha!
I just got my email invite to the Github Copilot tech preview. So I'm definitely thinking of "Code as ML" ;)

I think we begin to see software construction design oriented towards "agents". Analogous to previous abstractions like "daemons" or "running programs". They have permission to "self-assemble" intelligently.
It's also a way to hedge risks. If you've got a single programmer working on something, they're a single point of failure and they also have huge leverage (which can be good or bad depending on the person and circumstances).

Not that middle management bloat isn't a thing...it definitely is. But I don't think it's as black-and-white as it's made out here.
I think decentralized identity has a lot of potential. Using a web3 app was kind of an eye-opening experience to me - I didn't make an account, and the developer of the app isn't managing the data involved. There's tradeoffs here from a usability and security standpoint(now I'm responsible for everything and nobody can help me if I lose my keys). But I think this stands some existing preconceptions about the way the web _has_ to work(just because it always has worked that way) on their head.
20.04 is literally the latest LTS version of Ubuntu. Windows 7 is TWELVE YEARS OLD. You're analogy is garbage.

On top of that, I've run the auto updater that comes with the GUI (does more than sudo apt update).

If that isn't sufficient to use 4 year-old bluetooth headphones that are older than the OS, and FireFox to watch Netflix, it is far, far worse than Windows. Look, I really want this to succeed, but be honest, it's far behind Windows and Mac.
Yeah this is a press X to doubt story if ever I've seen one.
They give a shit if you expect full pay for 7/8th of the work. And they give a shit if you only do 7/8ths as much as before you had a kid.
A lot of websites reject that despite it being part of the standard.
Host your own or tutanota if else.
Yeah, I also have one, and I'm not really excited for new products from that company, even if it's the only real device in it's field at the moment. The whole configuration app and strange ecosystem they tried to push rubs me the wrong way, and I probably won't be getting the wrist device if I have to deal with that.
Just wanted to say— in case any Fastmail employees read this thread— that I love Fastmail. Keep up the good work. That is all.
Or maybe they like what they do and don't have much else going on, and are happy to fill their time with more work.
I don't believe this one. I guess it's possible it was originally true, but I don't think it's relevant now. I've lived in a house where we let the lawn go. It got very brushy and wasn't usable by us anymore. It was difficult to even walk though. AND, by that point it was too high to cut back into shape with a regular lawnmower. So I keep my lawn trimmed for the practical reason of wanting to use it.
A big problem with verification is that with it one needs to prove that the vote had come from a legitimate voter and that he had not voted at most once. If the proof for legitimacy is not part of the vote it may have been just inserted by the system.