skysight-inc/HackerNews huggingface dataset:
A New Biomarker to Personalize Breast Cancer Therapy
That's roughly my understanding of this as well, pulling from whatever I remember from old immunology classes.

The human adaptive immune response is massively parallel, and you can liken it to multiple progressive selection rounds for antibody candidates. As such, it is intuitive that this process would create a set of antibodies that targets not just a single antigen in multiple ways, but multiple antigens in multiple ways, resulting in more robust response (see polyclonal b-cell response)

As for the latter, the issue, as already stated, is in understanding the side effects and efficacy profiles of said vaccine. Clinical trials are long and expensive processes.
Looks very cool. Know anyone who’s using it?
How many houses were built for those BILLION dollars to house homeless? My guess is zero.
Carbon capture is necessary, but it's orders of magnitude more expensive than just not releasing the carbon in the first place.

Preventing carbon release is a political problem, and OP could work to support pro-environment politicians.
The Metaverse Doesn't Need Physical Coordinates
I hope you’re not speaking to my up-thread mention of ADHD. A pill has not made me less, or more, lazy. Or +- prone to procrastinating. To the extent it’s helped with executive function it’s just made me less at odds with the world’s assumptions about how I exist.
No one has suggested one possibility: that this was the art work for an idea some Assyrian Beltway Bandit was trying to sell. 1000 units of Self-Contained Underwater Breathing Apparatus for the armies of Tiglath Pileser for the low price of 100 talents of silver. As seen on Rockovision!
I enjoyed Janeway's Immunology back when I was in university. It's towards the more technical side of the spectrum (textbook), but I remember it being fairly comprehensive for the early bits.
If you admit the last sentence is hyperbole I'll be a lot more likely to take your recommendation
Donate highly effective charities https://www.vox.com/future-perfect/2020/2/13/21132013/climat...
frogs too
> The US is a low trust society.

We chose this path. (Or at least, someone did.) There were explicit tradeoffs where we burned social capital in exchange for a bit of cash, and now the costs are coming due.
Cool idea. I have written quite a few command line utilities over the years for certain tasks and this would be nice for distributing it to people, especially less technical or people unfamiliar with the ruby ecosystem.
Why does this idea keep being perpetuated? Biometric auth is not "a picture of my fingerprint is the password."

Imagine a human guard tasked with authenticating people with a database of fingerprints. Someone comes up says that they're John Jameson, the guard takes their hand and makes an impression with some ink and paper and then compares it to impression they have on file for Mr. Jameson. Could you hack this system by lifting John's prints? Nope!

Why? Because the real trick to biometric auth isn't that your fingerprint is secret, it's that it's somewhere between difficult to impossible (depending on the metric) to produce a living breathing human with the same biometric readings as you. The strength of a biometric auth system is determined by how well it can determine that the reading it's taking is coming from a human. You don't ever have to rotate your fingerprint or your face because it doesn't need to be secret for these systems to work.
Weird thing is I worked at a few places and we all used this joke on each other managers, etc and I never felt burned by it- didn't seem to bother peers either.
as soon as I found out about the founder
I haven't seen any poll results (yet!), but I bet we're in a pretty small minority. Two spaces is jist what i find most aesthetically pleasing. Four seems to be the standard among my peers, and the apparent fact that the standard is historically eight boggles my mind.
Yes! My wife and my families both crossed that boundary (on opposite sides of the country) around when we were in high school and we both remember grocery shopping as a key difference.
If you see content that is not worth your time recommended to you then you can downvote it to stop trusting those who found it useful. It is all in your control as a user.

I didn't quite get what are the centralized incentives that lead to clickbait. Is it a comment about LinkLonk or centralized systems in general?

Centralization and decentralization have trade-offs. Right now the downvotes on LinkLonk are private. The upvotes are semi-public, but not available in raw form. If you wanted to implement the LinkLonk's algorithm in a decentralized manner then you would need all hosts to make the upvote and downvote data available to all other participants. Maybe homomorphic encryption can solve this problem.

My goal is to build a proof of concept in my spare time and the centralized approach seems to be the right option in my situation.
Instructions like this need to be interruptible since they take longer than standard instructions. I assume the ARM designers have thought about this?
Is your theory here that money is the main motivator for job choices? Some people are surely like that, but for a lot of people, developers very much included, other things matter more.

I was just talking with a friend who recently left Google. He's now trying to figure out what to work on next and has spent the months since reading widely. As we were talking, he gestured at the wall of bookcases behind him and said, "I'm not really concerned with maximizing income. I can already buy all the books I can read."

And personally, I'm at a not-for-profit because I want impact. I could make a lot more money elsewhere, and I certainly have in the past. But when I look back on that stuff, a lot of it just looks like a waste of time to me. The financial traders I worked for took in money that would otherwise have been hoovered up by other traders. The excellent code base that never got any users because the business side was kinda fucked up. The enterprise system that limped along a while longer thanks to our stress and overtime. Life's too short.

And I really get hunterb123's perspective here. I'd rather be part of a small team getting shit done rather than a highly paid developer on a vast effort to shift some ad-revenue metric by 0.2% over the next quarter. Some people like that and it's fine. But in interviews I've asked enough former FAANG developers, "So why did you leave?" that I know it's not for me.
Some amount of assets listed as stolen by burglars is insurance fraud. Does that matter? Not really, because it's a small percentage that doesn't change the fact that most of it is crime.

Civil forfeiture doesn't require the government to convict anyone, or even arrest them, for that matter. The vast majority of the money that comes from this process comes from people we're supposed to assume innocent, since they haven't been proven guilty. Due to that, we have to assume that all of the money that comes from this process without convictions is stolen from innocent people.

If the government wants to seize the assets of people it convicts, that's one thing, but taking money from people and making them pay to prove it wasn't related to crime is absolutely theft.
iCloud backup alone is worth it. If you have nightly backups and lose your phone you can just buy a new one and restore.
The tough part with these arguments is that's it's not "if you didn't have kids", rather, it's "if a very large number of people didn't have kids".

If a small group of like-minded people decide to not have kids in the name of the planet, the effect would probably pale in comparison to the masses that don't hear and/or don't care about these climate change messages. I imagine the "real" solution would have to be one that doesn't require people to willingly change their way of life.
There's a good reason southerners have a historical reputation for being polite. If you weren't, someone might just challenge you to a duel.

I'm not convinced the shift away from that state of affairs was a net social benefit.
Baltimore is a tough place to run a business. You can expect to see the following every night in the downtown area:

>Offenses that will no longer be prosecuted include drug possession, prostitution, public urination, and open container laws, among others.

List comes from an article published by the same outlet earlier this year:
https://www.insider.com/baltimore-will-no-longer-prosecute-d...
Ask HN: Why are online phone number lookup systems so FN horrid?
Every single site is malware/spam - there is no way to look up a random number reliably.

Any insights on HN on this problem?
Part of it is certainly getting consumers to understand that any time it’s a free trial they are going to try and get you to just pay (hope you forget). What I’ve noticed with apple has been encouraging, lots of messages letting you know that you will be charged and on what date. I mean the better design is to just give the trial and then when it’s up ask if you want to subscribe or give an option to start the subscription right after the free trial.
AES keys are salted. Moreover, if you use public key authentication (e.g. smartcard, FIDO) it's not a requirement that any keys are provisioned on the user. I'm not sure if you can disable the generation of the NTLM key when using passwords, though (and it's true, that is unsalted).
I'm a founder at heart; I've loved creating - and have a software background. I really resonate with the paraphrased vibe of way, way more SaaS companies. I've been looking outside of SaaS to potentially harder science companies rather than SaaS for future endeavors.

It is too easy to: splash page, Wordpress, "rails new saas" for a product and then try to sell via SEO / outbound, etc that the field is quite saturated - and un-discovered niches are a lot harder than say 2013.
I don't think my skills are super applicable to working on climate change directly, so instead I work for big tech and donate to charities from this list. https://www.vox.com/future-perfect/2019/12/2/20976180/climat...

If you're not totally set on doing direct work for climate change, you could consider a similar strategy. In my case, I think it's probably more impactful than I could be if I tried to pivot into a climate-related career.
> I had a conversation with a traditional retailer who was afraid of using Heap for analytics because we used AWS for hosting, which is owned by Amazon, their biggest competitor.

It sounds foreign now, but when AWS was new this happened all of the time: Companies who saw Amazon as a competitor in some way usually had someone, somewhere in management who was afraid of using anything hosted on AWS.

It sounds silly now, but I remember having a lot of these conversations back when AWS was new. Typically, the older the company's management, the more likely they were to be afraid of using AWS for anything related to their business.
In a way, people are already "paid" not to have kids, since kids consume enormous amounts of time and money.
Program comprehension of domain-specific and general-purpose languages
The data shows children don't necessarily make life more fulfilling.

https://ifstudies.org/blog/does-having-children-make-people-...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222535/

https://www.pnas.org/content/111/4/1328
If things get to that point, the government might as well just buy all the housing.
You can't be serious? There have been congressional hearing on big tech monopolies and stopping "disinformation". The CEOs of the FAANGS were intimately involved in the presidential election last year.

If anything, tech weight far more power than any of the other industries you mentioned.
Compare that article:

> Shannon (1956) looked at the concept provided by Turing to make a mechanical or other electric machine and made an error in the description. Unfortunately, Shannon described Turing's machine as a system that requires "a control element, a reading and writing head, and an infinite tape". It was not Turing that stated that a Turing machine must be infinite but rather Shannon. Whilst Shannon produced some excellent engineering; he was not a mathematician. -- Craig (Fraudtoshi) Wright

to

> Some years ago I was researching on what might now be described as an investigation of the theoretical possibilities and limitations of digital computing machines. I considered a type of machine which had a central mechanism, and an infinite memory which was contained on an infinite tape. This type of machine appeared to be sufficiently general. One of my conclusions was that the idea of a 'rule of thumb' process and a 'machine process' were synonymous. The expression 'machine process' of course means one which could be carried out by the type of machine I was considering. lt was essential in these theoretical arguments that the memory should be infinite. It can easily be shown that otherwise the machine can only execute periodic operations. -- Lecture to the London Mathematical Society, Alan Turing, 1947

Turing himself directly refutes Wright's nonsense and did so over 70 years ago.

Wright also claims that Shannon wasn't a mathematician... but Shannon's PHD was in Mathematics! ... and isn't it usually engineers who dispense with the infinities? ... Wright better let the NYT know than Shannon wasn't a mathematician ( https://www.nytimes.com/2001/02/27/nyregion/claude-shannon-m... ).
True but nobody wants to hear it.

Hell of a lot more effective than punishing yourself to reduce global meat consumption by .00000001% .

Or just come to terms with the fact that for good or bad you just don't matter and try to live your life without doing unnecessary excessive harm.
> money can create "businesses" that shouldn't exist. Then people get too tangled up in the fake business that it's impossible to live without, all the while never actually earning profits you'd expect from a "good, large business".

like Uber, Lyft, Snapchat, DoorDash and many recent IPOs of terrible businesses that went public to make investors rich, while being terrible, money losing operations
It's definitely not the standard. It's a standard for one project that started decades ago.
It's about gist, not a general git repo, so no .editorconfig there.
There is a company in Russia called Postgres Pro https://postgrespro.ru/ and they are those people who added json functionality to postgres. As far as I know they work on full text search for postgres now.
Sudoku on a Mobius Strip
If you write a series of blog posts about these books, and talk about whether we should read them or not, that would be totally cool to see on HN and also very meta.
what about heavily promoting contraception?
Canadians have re-elected a Liberal government
Exactly, they are the primitives of security systems. If passwords are broken, then every other security system is suspect. If users can't be trusted with passwords because most people are really bad at it, and people are bad at it because they are human, why should I trust MS's human developers to do any better? Why should I trust anyone to do better? Exploitable software has resulted in far more economic damage than bad passwords.

It seems like a massive XY problem where somehow many people have come to the Y "let's get rid of passwords" as the solution, when the X is a mixture of solved problems:

- "people are bad at entropy" (password gens, sensible entropy rules)

- "people are bad at memorizing orthogonal unique strings" (password management schemes and systems)

- "passwords leak" (detect wild passwords and facilitate rotation)

The humble "secure string" allows the implementation gamut from "hunter2" to kilobits of noise, stored in a browser, chip, or post-it. Just prevent the worst incarnations. Passwords are not broken.
Do you think that is the case with the overwhelming majority of people?
Fine, but a cultural shift away from eating meat for 3 meals a day would have a big impact and how does that happen except at an individual level?
The comments here seem to think that children raised by what appears to be an intelligent, service-minded individual will not be a net asset in addressing the problems the future holds. I disagree.
Show HN: sirubo – ASN prefix (big tech) outbound traffic blocker
The only practical benefit I can imagine is that it puts a deadline on the damage from a root compromise. Not sure how much that's actually worth though.

If you're designing a device that cannot be updated (or won't be), you probably shouldn't use Web PKI. Even if the roots didn't expire, I'm sure the BRs would eventually evolve to preclude issuing leaf certs compatible with the devices.
The company is the product. The exit is the profit.
I don't think typing is the main obstacle to Python performance, otherwise it wouldn't be that much slower than JavaScript. In fact, there are several alternative interpreters that are much faster, but they entail incompatibilities with popular packages. Static typing cannot fix this.

Now, my dream would be for Python to actually enforce type annotations at runtime when they exist. Maybe add some kind of syntax to avoid doing it when it's expensive, e.g. `list[nocheck int]`, but for the love of god, enforce it, otherwise I feel like I'm just peppering my code with limp suggestions that only stand if some third party package can find all paths that lead to them, at which point I'd rather use a true statically typed language where the whole system doesn't look and smell like a janky afterthought.
The main issue now is how little time we have left. We're already past the tipping point, and there's about a 30-50 year horizon before it's too late to do anything at all.

This means that the following are going to take too long:

- "Doing your part", i.e. the regular "don't eat meat", "consume environmentally friendly things", and all those things that will only work over a horizon of 100+ years.

- Accumulating a ton of wealth and then using it to lobby. This would have worked 50 years ago but we need people to use this kind of big money NOW.

- Helping activists set up their websites and other tech things. We're past the point where activism alone will save us.

Our world has just started runaway heating, and Arctic methane is now being released, which is 100x worse than carbon. The ONLY thing that can save us at this point is a hail Mary shot of sequestration of greenhouse gases and at the same time, active cooling of the planet. Build this kind of tech, or join others building it. There are a few companies coming out that do this kind of thing. We need breathing room above all else, because even with tech 50 years is very little time.

Edit: Aaaand now the downvotes. I don't know why I even bother contributing here.
I think it used to be a good thing and people actually like the update. But now they got update fatigue, mostly because updating aren't exactly a smooth process and doesn't actually add any value to their usage.

They should go back to the old style where major OS update happens every two years. Although I am not sure the current Apple understand this.
How to pass a closure as an argument in Swift
If I was Apple, I would spin off FaceID as a separate business. It is proven at scale, can be packed into tiny device and no worse than passwords. It is beyond me that I still have to carry rectangular cards to buy something or have little book to get through Airport or type password to login anywhere.
In case of web apps/sites you can easily find truly dead code by inserting instrumentation/reporting in all the old workarounds and collecting it over some reasonable period of time.
I wish they’d come out and say that Windows Server is just going to be tracking kernel/plumbing changes from the mainstream release and no new features are planned. The biggest “feature” in Server 2022 is that you can now address more cores and RAM (2048 cores and 48TB) because apparently SQL Server needed that.

I see every day someone coming onto r/sysadmin saying “oh I have this SBS 2011 server that really needs an update” and all these graybeard Windows admins come out of the woodwork screaming about how they need to set up a old school AD domain controller and print server and all this crap. It’s dead guys. New apps should not be adopting Windows Server.
it always has been.

one thing i noticed more recently is the language used; before, you'd search "867-5309" and get the usual wording like "Looking for 867-5309?", now it's "WHAT THE HELL DID 867-5309 DO?!?!??!" or worse :D
Just promote education and economic opportunity for women. They will consequently have less kids and later in life.
I enjoyed this episode of "Ologies" talking to an artist, Andy Hall [0] working on what he calls the "The Drawdown Design Project" - creating inspirational posters and raising money to go towards the rainforest coalition.

Basically he had the same question, talks about the themes in the posters, empower - engage - cultivate - electrify. When asked what the average person can do, his answer was basically 'donate money to elect democrats' and honestly I agree. You can spend thousands of dollars or thousands of hours of volunteering, but its the politicians that are deciding how to spend trillions. Outside of that, I can recommend the book "Climate - a new story" by Charles Eisenstein, it argues against focusing on a single metric of CO2 ppm (and includes an aside on the war-analogy we default to when we decide to fight something ;). Basically it suggests we focus more on creating a healthy biosphere, explains the connections between weather, chemistry, and life. It's got me convinced that planting trees is the right approach, but not just to sequester carbon, but to increase the amount and variety of life on earth.

[0] https://www.alieward.com/ologies/drawdowndesignproject
The Things Network on PineDio Stack BL604 RISC-V Board
Then maybe only 30 years ;-)
Biggest problem about climate change is political correctness. We're too afraid to talk about the real problems and solutions because of "votes". Instead, we focus on small wins without any real impacts because it's "safe" and make people happy, like recycling.

Real problem and solutions:

- energy -> Need hydro or nuclear. Everything else is just marketing bullshit. Windmills aren't reliable, you still need a way to store the energy and have a backup. If you factor in the cost of that backup and other solutions, you soon realize that hydro (or nuclear if hydro isn't possible) is way more cost efficient.

- transportation -> Living in a suburb should have a penalty cost. Just compare the environmental impact between an apartment in a city and a mansion in a suburb with 5 cars. One is killing the planet much faster, there should be a penalty for it. I'm not saying forbid living in a suburb, I'm saying there should be an additional cost to living in a suburb because of the environmental impact.

- greenhouse gases -> penalty cost in proportion to the damage caused (for instance, buying meat from livestock should be WAY more expensive.)

I'm not a climate change expert, but I do know that people react to incentive. And right now, there's no penalty to killing the planet so we can't blame people for making the decisions they're making. And policy makers can't set real policies because of fear (rightfully so) of not being elected.

It seems like we'll need to wait until the Earth is almost doomed before implementing these policies, but then it might be too late. Maybe another way is to have a "bad guy climate change" that all political party would need to take into account as part of their mandate, so the votes would be about who can best solve these issues rather than whether they should be tackled.
If satellites fly high, and close enough together, there is no problem to send data in between them, as beams will not cross the atmosphere.
SF prank artist turns 'ghost town' Google office into a Spirit Halloween store
You cluelessness is jaw dropping. It takes 10 years of professional work for somebody to get reasonably good at writing software. And most software developers are still not that good after 10 years. There is a reason why companies in a fee market economy are willing to pay high salaries for software developers.