skysight-inc/HackerNews huggingface dataset:
If anyone will enable the world to engineer biology, it's Gingko.

Their team has built a platform for biological engineering since day 1.

This is the summary:

* platform for engineering biology (unfair advantage is they've taken this "not a product company" approach since 2009)

* investing up the ecosystem by taking upside in products they engineer for larger companies (not sure if they have an unfair advantage here besides creative financing and momentum, IPO helps with that)

* investing downstream into startups by providing their platform in exchange for equity (YCbio partnership seems like an unfair advantage here)

* mindshare of new minds (iGEM itself is a breeding ground for future synbio employees and leaders who dream of joining Ginkgo, Ginkgo founders co-created iGEM)

Pretty perfect flywheel right there, even if it risks being a spaghetti monster from a corporate structure and cashflow standpoint.

So cool to see this finally coming to light as an IPO. While I don't understand the SPAC benefits, Ginkgo's structure to be able to invest resources into synbio startups in an equity exchange sets them up really well for future cashflow even if the present is not.

(Disclosure Ginkgo bought lab equipment from me in the early days, and I just bought their stock today) https://www.ginkgobioworks.com/2009/09/01/pearl-biotech-open...
If a pedestrian got hurt, what would be the legal liability of the driver who didn't have his hands on the steering wheel?
there are potentially ethical issues if they did a real measurement from end-user browser. Similar measurement from Academia https://conferences.sigcomm.org/sigcomm/2015/pdf/papers/p653...
Soldering isn't the hard part. People can do that no problem.

The hard part is understanding the device without schematics. See https://www.wsj.com/video/series/joanna-stern-personal-techn... for a very good explanation of the issue.
No, you're conflating "loss" (negative profit) with "cost". The first sentence acknowledges that plenty of tech companies IPO and are not profitable, so their revenue is below their costs. The second sentence is about losses (negative profit) exceeding revenue.

For a naive example, a company can have $1m in revenue and $1.1m in costs, therefore profit is negative 100,000 dollars - the company is unprofitable. However, they are not losing more money ($100,000) then they are bringing in ($1,000,000 is greater than $100,000) - though they are spending more money ($1.1m) then they are bringing in. This would not be a concerning amount of loss, many companies are deliberately outspending current revenue in order to increase future revenue/growth/market share, but could become profitable if they wanted to.

In this case, the person you replied to is remarking that the losses/negative profit
($192m, $130m) are greater than the revenue ($152m, $81m). This is a concerning sign, as the path to profitability is much further away.
My personal site does the job (https://guido.io), it lists some old and current projects and it allows me to post some snippets of knowledge every now and then as a blog. There are a hundred ways I want to improve it, but it is rarely at the top of my priority list.

I started with just some HTML and CSS, and later shoe-horned it into a Hugo template which required some awful custom theme hacks.

> But I'm also curious about what stack was used to make your site. I've looked at static site generators, but none I found felt right to me. I guess it's one of those cases where if there is no clear winner, then the problem hasn't really been solved yet.

It's fairly simple to create your own static site generator in any programming language with different tradeoffs, I think that is one of the main reasons why there are so many out there. It's about the content and your visitors won't care which framework you used anyway - so just pick one and be done with it. You can port your content over if you ever want to switch.
Can we please start the geoengineering R&D work now? Let's not have those positive feedback loops start spiralling out of control.
As nice as this looks, I've been working on something similar and immediately see tons of limitations.

Things like:

- batch editing: what if you don't want your edits to save immediately, but instead as a group?

- item creation and joins: what if some fields create items that have ids that other fields require for update or their own creation?

- discarding edits: what if you want to throw away your changes?

- front-end auth: how do you verify that a field is editable before creating a text box for it?

- front-end validation: how do you make custom field validators?

- mid-edit derivative values: if you change something without yet saving it, will the other parts of the ui using that value also show updates?

Solving all these issues has been a tough project. I started off wanting to be able to just pass a rowId, tablename, and columnname, but pretending things are that easy only works for very, very flat Databases. (no joins)
I'm grateful to GitLab for providing an alternative to GitHub, and an open source one. It's an open core product with the community edition providing a lot of value. Here are some community hosted instances: https://wiki.p2pfoundation.net/List_of_Community-Hosted_GitL...

The CI system is quite powerful, and Travis CI's struggles before and after acquisition has shown that it's hard to host a major CI platform.

I hope the company and the open source product will continue to thrive.
First sentence: 'I realise many ... profit < 0'

Second sentence: 'Seems scary ... profit < -revenue'
"That only happened after Facebook decided to editorialize everybody's main view. People were not even used to sharing news at that point, but it was the only thing that Facebook allowed to spread."

That's a great point, I hadn't considered that. Thank you!
This person is not a Tesla employee being trained and paid to test this extremely dangerous piece of software that has already killed at least 11 people. This is obviously unacceptable, and no other self-driving company has taken the insane step of letting beta testers try out their barely functional software.
Cureus – Palpation of the Respiratory System in Osteopathic Medicine
I think that would at most be soft-real time.
IMO there is so much 'machine learning' in the tesla self driving system is there any way to know a bug is 'fixed' other than just running it through a probably totally boring set of tests that doesn't even approach covering all scenarios?
If this search engine ever takes off, the listicle writers will just start optimizing for it too, right?
Especially considering the narrow interpretation the op is using for both songs. It's amazing how easily people will gaslight themselves.

> The lyrics reflect the concern felt by Strummer about world events with the reference to "a nuclear error" – the incident at Three Mile Island, which occurred earlier in 1979. Joe Strummer has said: "We felt that we were struggling about to slip down a slope or something, grasping with our fingernails. And there was no one there to help us."
> The line "London is drowning / And I live by the river" comes from concerns that if the River Thames flooded, most of central London would drown, something that led to the construction of the Thames Barrier.[1][5] Strummer's concern for police brutality is evident through the lines "We ain't got no swing / Except for the ring of that truncheon thing" as the Metropolitan Police at the time had a truncheon as standard issued equipment. Social criticism also features through references to the effects of casual drug taking: "We ain't got no high / Except for that one with the yellowy eyes".
> The lyrics also reflect desperation of the band's situation in 1979 struggling with high debt, without management and arguing with their record label over whether the London Calling album should be a single or double album. The lines referring to "Now don't look to us / Phoney Beatlemania has bitten the dust" reflects the concerns of the band over
its situation after the punk rock boom in England had ended in 1977.

Michael Stipe isn't exactly fond of explaining the meaning behind the lyrics of many of his songs but I somehow doubt the song was made to ease the concern of a real future climate catastrophe.
Due to the feedback loops, isn't 2.9 potentially significantly worse than 2.8 versus 2.8 compared to 2.7?
I think the article is talking about waste in the form of ASICs used for mining that need to be constantly replaced with upgraded versions to remain profitable, so it's already physical vs. physical.
Both of which have excellent weekly podcasts covering their articles and other science news of the week.

Oh, and speaking of Science News, that is (was?) an excellent weekly with short articles on recent results. I just haven't subscribed in a number of years.
I hate how it has now started slipping Hollywood movies into my recommendation feed. All of a sudden i'm seeing the credits on a 2 hour movie after watching a 15 minute UrbanX video. NO YOUTUBE, BAD. If I wanted to watch shitty movies I wouldn't be on YouTube.
You can achieve this without electron. My criticism had nothing to do with that use-case.

The whole concept of "discounting criticism" based on... what, exactly? is preposterous.
At this point they're massively overvalued if you ask me, that seems to be the case for every synthetic biology company but this one takes the cake.
VW may be on the path to delivering such a "Costco EV car" in the near future, but haven't hit it today. Their ID.3 is the current closest, isn't sold in America, and starts at 33.900 Euros (roughly USD$39,700 at today's exchange rate).
I do not see how the pedestrian would have benn hit. For me the car was turning very sharply, away from them.
But ideally you shouldn’t have to trust them.
People in private equity/finance are pretty out there in terms of competitiveness and aggressiveness. I would not use them as a barometer for all millionaires and billionaires and no they don't make up the majority of either of those categories.
This - the tipping point where a glacier melt is sped up, and then exposes peat and releases more co2 etc etc - there are so many little tipping points that we just don't know about. Maybe easy alone would have a minor impact, but cumulatively the impacts may be huge.

A lot will also depend on the state of society in general when the things get tough, will extreme heat or extreme rain come during a war, or economic downturn, or in a pandemic?
Amazon Surpasses 10% of U.S. Digital Ad Market Share
Does anybody actually embrace Gitlab fully?

Anybody I've seen uses it for git, and at most CI/CD on top. But who else (other than gitlab themselves) uses all of their stuff.

They're pushing really hard for that with their "the devops platform" thing, etc.
Visit in incognito mode and don't sign in. Brand new, fresh youtube, ready to be corrupted again.
True, but sometimes you have a big lump of early employees become liquid at the same time. That’s a not a recurring event, which is important when deciding how viable the business is.
I think we are beyond semantics. Calling it smothering, greenhouse, warming, climate change, etc. doesn't make a difference. The only people who still want to believe that it isn't happening won't be convinced by names.

They'll be convinced only when it (drought, desertification, flooding, hunger, etc.) affects their own neighborhood.
Google’s 3,900-Mile Grace Hopper Undersea Cable Lands in the UK
> the Chevy Spark to date has never been an EV.

Yes it has: https://en.wikipedia.org/wiki/Chevrolet_Spark_EV

> Chevy's Bolt, their current closest to an entry model EV, still starts at $36,500.

It starts at $31,000.
Hey folks, just find this post, I’m go-app’s creator. Looks like a bunch of the discussion is about the wasm size. When its gzip it is not that big. People are talking about 15MB, none of my projects reached that size, and they are usually pretty liked by my users.

For the syntax, it is a matter of tastes but things that people like about it is that its full Go and everything is discoverable from your editor with auto completion.

At the end what’s matter is that it’s good enough to build beautiful UI only by using Go and it’s ecosystem.
Wind and solar can get you very far and are significantly cheaper and easier than nuclear, so it only makes sense that we ramp that up to 50%+ of the energy mix immediately, with power lines and natural gas peaker plants in place to smooth out temporal availability.

I'm not discounting nuclear and see its value for base load power, and I think anti-nuclear energy people are puritanical idiots and definitely do not want to vote for anyone who is against nuclear, but I get the sneaking suspicion that nuclear power is often mentioned as a way to misdirect away from wind and solar for political reasons which is a shame since these technologies are such easy wins that can be implemented right now.
I don't think urbanism has been affected that much.

In my neck of the woods (SE Florida) urbanism didn't lose a beat. Rental apartments in my neighborhood are leasing at above asking. There were a few months where the city felt abandoned, property values were down, and leases were offering signing bonuses.

It's done a 180, or 360 now, city property values are climbing. New construction is way up, even with the high cost of labor and material, and shops and bars are working with the new normal. My city has taken advantage of decreased traffic to institute popular pedestrian projects that were unpopular to commuters.
Turning the other cheek is something different altogether.
Apple may boot Facebook from the App Store over human trafficking concerns
The whole personal computer market was growing explosively back then, in the UK as well as the US. The first British computer magazine was Personal Computer World which made it's debut in 1978 with the British NASCOM-1 (Z80-based kit) on the cover. Sinclair's SC/MP-based MK-14 had come out the year before. The UK was only slightly behind the US, with the Apple I and KIM-1 having come out in 1976, then Apple II and Commodore PET 1977.

Acorn's first venture was a microprocessor-based fruit machine controller, but back then it was a no-brainer for anyone in the electronics business to get into computing, so pre-BBC we have the Acorn Atom and Sinclair ZX-80 both introduced in 1980.

We can really think the BBC for the foresight in coming up with a national computer education program, and doing it the way they did - by asking for proposals from British companies to build something to their specs (including a color display).

However, even without the BBC no doubt Sinclair and Acorn would both have developed follow-on products to the ZX-80 and Atom. The Apple II was revolutionary in having a color-display, but it was certainly pretty basic, and screaming for someone to do better, which of course Acorn (BBC micro) and Sinclair (ZX Spectrum) both did.

I got my first job out of college at Acorn. I just wrote to them and said I'd like to work for you, and after a token interview they said yes. I guess I can thank the BBC for that since it was the sales of the BBC micro that was causing Acorn to grow so fast. At that time they had just moved out of the Cambridge marketplace location to the old water works on Cherry Hinton Road.
> e.g. I can buy a 2003 Honda Pilot 4WD for $5,600 which probably has a good 200k miles left.

I frankly would not take that bet. There are many catastrophic (costing more than the purchase price) repairs that can come up between 100k and 200k. If its survived that long it probably has more left in it, but a lot depends on how its been driven and maintained.
Introduction to PyTorch Lightning
IIRC Google storage, Youtube premium, TickTick premium, Netflix (more for the family), Prime (for the free delivery, not the video)

I prefer one-time payment when possible (as a client, of course..)
Definitely. Volkswagen is very different now, but I believe it has its origins in producing basic cars that anyone could afford: https://en.wikipedia.org/wiki/Volkswagen#1932%E2%80%931940:_...
If "ice" and "no ice" were the only two possible scenarios, sure.

Unfortunately, it's entirely possible to go too far in the other direction. https://en.wikipedia.org/wiki/Wet-bulb_temperature

> Even heat-adapted people cannot carry out normal outdoor activities past a wet-bulb temperature of 32 °C (90 °F), equivalent to a heat index of 55 °C (130 °F). The theoretical limit to human survival for more than a few hours in the shade, even with unlimited water, is 35 °C (95 °F) – theoretically equivalent to a heat index of 70 °C (160 °F), though the heat index does not go that high.

> A heat wave in August 2015 saw temperatures of 48.6 °C (119.5 °F) and a dew point of 29.5 °C (85.1 °F) at Samawah, Iraq, and 114.8 °F (46.0 °C) with a dew point of 89.6 °F (32.0 °C) in Bandar-e Mahshahr, Iran. This implied wet-bulb temperatures of about 33.5 °C (92.3 °F) and 34.7 °C (94.5 °F) respectively. The government urged residents to stay out of the sun and drink plenty of water.

Hit 35 °C wet bulb somewhere heavily populated like Bangladesh for a day and you're looking at significant casualties.
Ask HN: Best resources for non-video based math self-study
Hi, I'm doing a Master's in Music Tech and need to get my math up for DSP programming. I'm trying to find good self-paced online courses that aren't video based. I just want to read text. I need to go back to basics because it's been 30 years, but I want to be able to go through content quickly because I was an A+ math student 30 years ago! Any recommendations? The goal is to get to be able to do university level DSP, assume I've forgotten stuff right back to senior high school.
That's fair, and I appreciate the counterpoint. There is a mess of conflicting issues in something like this.
It has to be in the US due to FPTP voting. That's how you build a coalition. Getting Republicans on your side won't do any good because they don't vote in your primary.
My actual experience with reporting the "something broke" in a large, popular OSS project was 18+ months until resolution. A crafty engineer thought it was a good idea to run their in-house optimization on third-party JS libraries to squeeze a few extra bytes out of the final bundle size (going above + beyond conventional methods like minification). Turns out that the overly aggressive optimization caused runtime exceptions, and they ended up cleaning up the feature.

I've never had a good long-term experience with tools that try to be or solve everything for me, and today I avoid them.
FYI, that 99.999999 number you quoted is still bad. It means around 30 minutes of the machine actively trying to kill you or others while driving on public roads. I assumed a person driving 2 hours a day for a year.

FSD should not be allowed on the road, or if it is it should be labeled as what it really is: lane assist.
The animated rain background absolutely kills Firefox on my machine for some reason.
Once you start watching Alex Jones videos, the algorithm starts to bubble up some nasty stuff.
I'm on crowded public wifi right now and the site spent 4-5 seconds on the loading screen.
Best Digitizing Service for Embroidery
The point is those stories remain local news, but whenever a Tesla is involved, it becomes national news.
Computer science degrees are a waste of time and money unless you want to go into academia. If you ignore FAANGs you can get a very comfortable job as a developer after a bootcamp & internship.
The real money comment in this entire thread. Corporate incentive structures are messed up. Why does a corporation sacrifice principles and values over money. If they really care about the people they serve they would consider this seriously.

One of the first things I was told when I joined FB was that they were almost going to be decentralized and a non-profit. Who knows how much of that history is rewritten.

I mention it because there are echoes that these big tech companies could have been non-profits. Google making information accessible. Apple making computers that enable people to learn and create. Facebook connecting people and creating community. Amazon to empower small businesses.

They probably wouldn’t have succeeded as much as they did now. But they certainly deviated away from their original mission, or rather they have a history of compromising them for profit. We should be trying to create a world where they would have succeeded as a non-profit.

Our incentive structures for corporations are so screwed up. But this is so complex. Probably the first step is improving the bottom line for everyone in the country, and then we can start tearing apart the incentive structures for businesses.
GH was far from the only one around at the time, but it was by far the most market-friendly for what it was. Timing was a big deal too, I think.

But yes, agreed.
For this on steroids (in a good way), see https://mynoise.net/
You can actually see their salary calculator here https://about.gitlab.com/handbook/total-rewards/compensation...
Or maybe it's just what HAPPENS in real life when you have a son and a daughter, and it's effects can be seem on a societal level through, for instance, the number of male vs female hard science college applicants for instance. Different genders have different interests on AVERAGE. The fact that nature doesn't conform to a idealized view of an equal world does not make it "wrong".
I am not a big shop - I work on a team on the order of 10

We use GitLab as our "one place to do the entire software development lifecycle". It's a really good CI/CD runner in my opinion, the .gitlab-ci.yml files are expressive and enable reuse thru a pretty nice inheritance model, and integrating new service (container) builds is literally 4 lines of code to have every push build a new container and put it in GitLab container registry.

It also makes developing NPM packages a breeze, thru the same reuse of CICD files we can drop 4 lines into an JS/TS repo and have it publish to the built-in package registry on tags.

On top of this, its ticketing system is worlds better than GitHub's. Less clicks, more available relationships & tags, more views, inheritance/rollup via the group structures you can put in place let you view tickets at a repo / group level, and since you can create trees from the groups you can have reasonably expressive places to view groups of issues.

Finally - it's all free! We're using free tier self-hosted, and it's far superior to my experience with GitHub paid. I admit, we have decent (read: overscaled) hardware to self-host on, but GitLab really does offer a ton of useful tools to building software.
It really says a lot that the figure people give is instantly the number of refugees.
News about climate change always reminds me of that "Truck almost hits a pole" meme [1]. We're always "on the catastrophic path" and "nearing irreversible damage" and "almost permanently fucked". I'm personally not a climate denier, but I can understand the skepticism. For the last 20 or so years, we've always been really really close to utter disaster. To get a little more provocative, it feels like Christians declaring Jesus will be returning Any Day Now, for the last 2000 years.

1: https://imgur.com/r/gifs/kuplW0m
My issue is that the problem is more about "energy" than heat. While the average over time will be a gradual warming, the impacts locally will be much different on the time scales normal people care about. We should be talking about weather extremes, not "heat." When we say the earth is going to get warmer, people think "fine, Canada is kind of nice anyways." In reality, we'll also see extreme blizzards, floods/rain, tornados, insect swarms, mass deaths of flora/fauna, and more. Pretty much all natural phenomena will be amplified both in terms of frequency as well as severity. And we may have many years before that 2.whatever C warming trend is realized, extreme weather events are increasing now. My home was almost leveled this year by an F4/5 tornado this year in an area where tornados are typical but never much more than an F2.