skysight-inc/HackerNews huggingface dataset:
Early epidemiology is showing better immunity from natural infection.

A receptor binding domain is the place the on the virus that the virus uses to bind to cells.

However antibodies can bind to any part of the virus causing the virus particles to be attacked by the immune system. It is good to bind to the receptor binding domain, but it is good to bind to other parts of the virus too.

As the virus mutates, having antibodies that react to as much of the virus as possible is better than only having antibodies targeted towards the RBD
This already exists in some cities. Though I would love this to be available in all major cities myself. Here in Vienna for example we have the CAT (City Airport Train) [0]

Its an express train taking you from a city center railway station directly to the airport in about 15 minutes and also allows you to check in and drop off your luggage up to 24h before departure.

It's criticized by locals as too expensive compared to the S-Bahn serving the same connection (just slower/with more stops) but especially for visitors it of course gives you the huge benefit of not having to deal with any luggage on the last day when you already had to check out of your hotel.

[0] https://www.cityairporttrain.com/en/news/unique-in-europe-th...
> I love the site, but his stance on this doesn't really make sense to me

would not be surprised if he has some personal axe to grind with cf (they are no sheep either).

also i would be wary of overestimating market penetration of any 3rd-party dns provider; iirc google has total dominance of this segment and is still below 10%.
AFAIK, it’s generally accepted that this particular virus has multiple animal reservoirs.

In the US, even white-tailed deer can be carriers: https://www.aphis.usda.gov/aphis/newsroom/stakeholder-info/s...

Unless I’m missing something here, 100% vaccination of human beings with a 100% efficacy vaccine would not eliminate COVID-19.
People are just fine at evaluating risk. It's just that the prioritization of the population is different than the prioritization of HN/Reddit/whatever. "People" aren't bad at stuff. On average, they're about average at it, which is tautologically true.

People don't wanna die in a car crash or from covid but they want to die at the hands of others even less.
Is that enforcement a positive thing or not?
Same has been common in other parts of the world.
Same here! I had access to prepaid cards, but sadly cloud providers just don't accept them. (At least DigitalOcean didn't!)
Shutdowns have occurred due to no appropriation bill being passed before the previous one expires. Raising the debt ceiling is a different thing. It used to be a routine thing to raise the ceiling because the monies have been appropriated. It was only under Republicans in the Senate trying to sabotage Obama that it became an issue.
Yeah I did edit that section:

"And that source will vary depending on what kind of random number generator you want to use.

I’m sure that last sentence caused some confused looks. What do you mean by “kind of random number generator”? Aren’t they all the same?"

Sorry if I came off snippy. I definitely appreciate the feedback.
You cannot separate economics incentives from networking protocols.

You need an actual sepeculative market to price and offer these services.

Most of open source fails because they don't acknowledge this reality.
"Long bike ride" - this is the way! Something about relatively steady low-intensity exercise does wonders for the brain.
The Final Android 12 Beta Is Here
I have a professional cloth kn95 mask. It is MORE effective then the cheaper models, according to the technical u. In Berlin. The number of layers, 5 in this case, and anti viral agents contribute.
I could see a couple ways to make it work - use the NVME drives they mention as swap space to get cheaper, but lower perf RAM, and put multiple vCPUs on each core. Lower performance, but still exactly what they offered.

But that's my skepticism talking.
The build tooling of Zig is very impressive. I'm a sponsor of the project not necessarily because of the language itself, but because it surely has the potential to make waves in some way or another (edit: though the language itself is also quite interesting).

One thing I wish the blog post had brought up is testing! Zig has some great tooling around tests, and that is something sorely lacking in a lot of C projects. If nothing else, you can pretty easily use Zig to simply write some tests for a C project! Even that would be a big improvement to the ecosystem.
Right - but now there's a chickenpox vaccine, so you don't need to subject kids to the misery that is an actual case of chickenpox or to the rare outcomes where it's fatal or permanently disfiguring.

How fortunate are we now that within two years of Covid emerging, we have a similar vaccine that can prevent nearly all the suffering?
> a storage plugin only had to implement the API methods upload, download, list and delete, so you could literally use anything as a storage backend (FTP, SFTP, S3, WebDAV, ..)

In the desktop world, this is pretty much the same idea as FUSE [1] for filesystems. It's really fun/easy to use FUSE libraries in languages like Python [2] to make mountable filesystems this way, which then allows for integrations with all of your favorite local software / shell commands / etc.

[1] https://en.wikipedia.org/wiki/Filesystem_in_Userspace

[2] https://github.com/libfuse/python-fuse
I used to use InoReader and Miniflux, but have since moved to newsboat (https://newsboat.org/) and love it.
Simula's portable Linux VR headset is also planning on including an Intel NUC 11 Compute Element: www.simulavr.com

The modularity of Intel NUCs is nice. We'll be able to offer a seamless upgrade to Alder Lake when it arrives.
Sure: Australia, stop focusing on cases and pay attention to hospitalization and death rates. Idk what your comment was meant to convey.
Here's a much more clear data set.

https://www.statista.com/statistics/1191568/reported-deaths-...

To put this into perspective... 36,000 people died of car accidents in 2019.

In the under 50 group around 20,000 people died of Covid.

The under 50 age group makes up around 80% of the population.

Interpret that however you want.
50°C difference or even higher? Damn mate, even Siberia only gets around -34°C which is less then that of you target the usual 18-21°C. Your winters sound terrifying.
A Simple Framework for Venture Capital Fund Law
Microsoft Pres Brad Smith warns that U.S. is repeating a key Sept. 11 mistake
Sorry, I should have provided more clarifying context. My point wasn't that this was a general policy, but that Australians have accepted a system of self- and AI-administered biometric constant surveillance for at least some citizens, some of the time. I could easily see this being used to enforce future lockdowns.
Immediately after reading the title, I knew Peter would be involved in its contents in some shape or form. Was not surprised when the first thing I saw was a picture of him pop up after clicking on the link. Took a philosophy class with him during my freshman year of undergrad before transferring to another university. Really cool guy that had a massive part in enabling my critical thinking skills.
https://archive.ph/w61lm
> There is merit for harsh policies if you can prevent any case, what NZ did relatively successfully. But admitting that it failed is hard to convey politically.

Note that the South Australia app under discussion is in an Australian state which, like NZ, is relatively successful at preventing “any case”. It seems like the last case necessitating a 7-day lockdown in SA was almost 2 months ago and before then they hadn’t instituted a lockdown since Nov 2020. https://en.wikipedia.org/wiki/COVID-19_pandemic_in_South_Aus...
Chiron is not a comet.
Talking a bathroom break was most effective to cure a blank mind during a long test at school. At least if they would let you go.
:/

just because rural folks don’t care the hospital is full doesn’t mean the hospital isn’t full
We Pushed Helm to the Limit, Then Built a Kubernetes Operator
The gamma function is part of the posix specification.

I suppose in an interview situation it might be advantageous to compare stirling & lanczos methods.

you're expected to know what -1 factorial is as well.
Going deeper into static constructors hole
It doesn't matter. People care more about the monthly payment than they do the debt #. You can afford a much higher debt burden if the interest rate is smaller.

For fun, assume you can afford $1000/month in housing costs. With a 30yr mortgage and 20% interest rate. How expensive of a house can you afford? What if interst rates dropped to 10%? 5? 2.5?

Very strong correlation with home prices over the last 40 years.
That's not the point that person was making. But (figuratively) its very true not many people at all can own such a car. Imagine owning one, you got well over $100k of f-off-money, but then tell your barista "life is rough with these car insurance prices on Ferraris". It's perspective.
this is a really cool idea!!
Interplanetary Network Database (2012)
> I wonder how many content creators are more comfortable with Python than with a DAW or Audacity?

This opens it up potential for a simple GUI. For a basic user, drag and drop an audio file and flip virtual switches. Or, easier integration into a mobile "podcast creator" app.
> “The biggest mistake was to miss Kubernetes. We were in that collective thought bubble where internally we thought Kubernetes was way too complicated and Swarm would be much more successful,” Jérôme Petazzoni, one of Docker’s first and longest serving employees, said. “It was our collective failure to not realize that.”

They were not wrong on saying that Kubernetes was very complicated, at least in some sense. In the beginning no one wanted to use it because they could easily setup Docker Swarm with minimal effort. This argument still pops up frequently on HN when there's a new post about Kubernetes.

I guess the problem was they didn't realize why Kubernetes needs to be that complicated. And if a system is complicated for good reasons, that's actually good business opportunity and tons of people and companies will be willing to make the effort to fill that gap.
I mean, I agree in general but it is also likely that they're performing at least some kind of background check on you when you participate in Pre. They definitely do with Nexus. It does make a certain degree of sense as a program if you believe in the premise of the entire security theatre apparatus to begin with. Especially within the US where domestic air travel has traditionally required very weak identification (driver's license).

That is, you're paying them for the privilege of reducing their attack surface a little bit.
It’s easy to find the answer to your question. One does not have to deliberately wallow in ignorance.
I mean, the mainframe-vs-commodity comparison on "planetmainframe.com" does not have the highest prior expectation of impartiality to begin with.
They could do this with ICE couldn't they? What does that have to do with EV specifically? It seems it just adds to the lore of Tesla - The Tech Car

Actually, ICE is quite significant in the degree of computerization Tesla can achieve. Since engine compartments can get very hot, ICE manufacturers have to use slower, specially hardened chips in such spaces. The Tesla cars, being EVs, don't need to do this. This results in more computing resources and less expensive components.

Granted, the other manufacturers could do this as well. But this should cause us to ask, why haven't they? Even GM and Ford haven't been able to achieve the kind of integration Tesla has. That warren of diverse microcontrollers and systems is associated with a warren of supplier relationships.

So, maybe it does have more to do with being "The Tech Car" -- but isn't that even more powerful and tied to the principle of disruption than just being electric?
A day or two ago, someone pointed to a great article on Melatonin[0]. I'm pretty sure it was a repeat, from a couple of years ago.

In any case, the thing that struck me, was the recommended dose, of 300 micrograms (0.3mg). Since the lowest OTC dosage is 3mg, and it goes up to at least 10mg, this was a shock. I have been taking 6-9 mg per night.

I immediately lowered the dosage to about 1mg (I have 300 microgram pills on order).

Slept like a baby.

[0] https://news.ycombinator.com/item?id=28416035
I have, since the beginning of my career, refuses to work for anyone that expects more than 40 hours per week of me. I ask it as part of my interview. I'm not against the occasional crunch, or traveling for work on occasion. Those are fine. But if an employer expects more than 40 hours per week consistently, I will simply not work for that company.

And so far, I have remained upwardly mobile, and more importantly, happy with the work that I do and satisfied with the amount of time I am afforded for friends, family, and hobbies.

Everyone searching for a job should be asking their employers hard questions. Job offers aren't worth it if you're being exploited.
Exactly, it will never go away for the same reason the unskippable ads in between turns on the hottest new mobile game will never go away. It's the torture designed to get you to pay up.
in the olden days dumb people just died and didnt reproduce. We have overcome a lot of natural selection so there are likely many more dumb people than in the past.

We all share the same reality that you have a .5% chance of dying from covid. If you choose not to take lifesaving vaccinations then you are dumb, especially if you are in a high risk category where the risk of death is 1-5%

Im not at all in favor of mandatory vaccinations.
Most people do not really work 70 hours / week. They just are present at work.
You're leaving out the most important part: cooking with gas.

"Natural gas and propane stoves can release carbon monoxide, formaldehyde and other harmful pollutants into the air, which can be toxic to people and pets."

https://ww2.arb.ca.gov/resources/documents/indoor-air-pollut...

"Gas stoves can generate unsafe levels of indoor air pollution"

https://www.vox.com/energy-and-environment/2020/5/7/21247602...
For some reason, I've always preferred photos of the planet from space when they are not shot with the earth "down below." I really get a sense of the weightlessness, and the feeling of traveling through space, if the Earth is to the side or at the top of the photo.

Your rotation simply doesn't look as majestic to me. I guess it just feels like it was shot from an airplane, even though of course I know rationally it must be much higher.
Osama bin Laden did not care about our freedoms, he wanted the U.S. out of the Middle East and believed based on Somalia that dramatically attacking us would lead to that result. This is well documented.

We have to be careful to not assign whatever motivation or outcome we don’t like as “the goal of terrorism.” You can justify anything that way, and people do. “If you do the thing I don’t like, the terrorists win” can cut both ways.

Terrorists have specific goals they are trying to achieve with violence, usually ideological or political or both. Bin Laden thought his ideology would have room to grow if he could scare the U.S. into leaving. He was wrong about that. The fact that we still have to take shoes off at the airport (annoying as it is) does not mean he won.
Not at all what I said. The hospital isn't full. Show me a single hospital that is OVER or AT capacity.

All the fear mongering articles say is the ICU is at 90%~

They are always around that number. Show me the percentage of covid patients in that ICU. Show me the normal number of the ICU.

Worry about obesity if you want to stop the number one and two killers of humans and relieve our healthcare system.
Quarantines and lockdowns were used against previous pandemics such as the 1918 flu pandemic.

American Samoa, for instance, was entirely unscathed by the Spanish flu because they instituted a strict quarantine at the border, the same policy Australia/NZ did for Covid-19.

See this pre-covid article from 2018, for instance.[0] Sound familiar?

> “These communities basically shut themselves down,” explains Howard Markel, an epidemiological historian at the University of Michigan who was one of the authors of the study. “No one came in and no one came out. Schools were closed and there were no public gatherings. We came up with the term ‘protective sequestration’, where a defined and healthy group of people are shielded from the risk of infection from outsiders.”

[0] https://www.bbc.com/future/article/20181023-the-places-that-...
4x the cost is actually not bad for the massive redundancy, hotswap-everything, boatloads of IO, insane build quality and crtitical legacy software support a mainframe gives you!
California moves to be the first state to outlaw 'stealthing'
Not at all, my 9.25” telescope has a focal length of about 2.4 metres - a focal ratio of f/10.

You’ll recognise f/x from camera lenses and such.

The diameter does control how much light the telescope “swallows” though, you’ll need a larger telescope to see less bright objects (or longer exposures, although when you are using your eye, that has a limit of course!)

So in this case, the post about is saying you’ll need something about 200mm diameter to see the comet. Anything smaller, and you’re just not getting enough light to see it.
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Wages for professionals, such as law, medicine, tech, finance, consulting, etc., have really ballooned over the past decade, since 2008 especially, even after accounting for student loan debt and inflation. This makes working long hours more attractive, as the financial payoff is so great both in terms of wages but also by investing one's income in rapidly appreciating assets such as stocks and real estate (the post-2009 bull market is the biggest and longest ever). Consequently, there are many people on Reddit and Hacker News on popular subs such as /r/personalfinance , r/investing, /r/financialindependence, /r/wallstreetbets (a lot of gambling, yes, but also many rich people who have 6-figures to play with) and /r/fatfire who have amassed considerable wealth by late 20 or 30s. Putting in long hours in your 20s and 30s to have a massive nest egg that will last you the rest of your life by your 40s seems like a good trade-off.
While I tend to agree, there's obviously jobs where familiarity with stack, tools and best practices is more important than engineering ability.
They may not be interesting, but they do seem to comprise the majority of openly availible jobs.

My current job has minimum emphasis on language (C#, targeting original Framework 2.0, no new features) and zero tech stack. On the one hand it is interesting - not enterprise stuff - and puts the brain to real use often, on the other, I think it doesn't provide anything market worthy to my CV. As most of my collegaues work for over 7 years there, it really seems to be so.
>If she can, then I don't see any issue at all.

>Why not use “they” instead?

It's been 30 years since I've studied formal writing in earnest, but "they," is, or at least was, grammatically incorrect in that sentence, unless you are referring to more than one person. English doesn't have a proper gender neutral singular pronoun. People have bastardized "they" to fit that role though because they don't know the gender, or because changing social and cultural pressures.

https://style.mla.org/using-singular-they/
> Blockchains like Ethereum are part of the solution which help prevent something like that from happening.

How so? The problem is that many humans are greedy. How do "Blockchains like Ethereum" fix that? The existence of a technology that's completely orthogonal to the problem isn't "part of the solution" although marketing it as a solution certainly does help move worthless tokens.
Interesting. i’ m studying airtable case. Any ideas on how they deal with thei internal docs?
alcohol more like
Not sure how you make such a dashboard when the expensive prevention measures affect the number of deaths. I think you are looking for number of deaths if the prevention measures weren't in place, but i'm not sure how you could arrive to that number accurately.
Regretfully, "Available to US citizens, nationals and LPRs" only.
It's close to the base rate. It's not a payday loan...
Theres some great work being done on zk roll ups you might be interested in.
I've experimented with some of this advice in my dishwasher, with mixed results. Some of the pod manufacturers explicitly state that the pods are designed to compensate for the lack of a pre-wash, so this isn't a case of Out-of-touch Dumb Companies vs Smart Customer. Whether you believe the makers is another thing, but I think the video is oversimplifying for the sake of making viewers feel smart and achieving factoid popularity.
> (making fakes impossible)

The problem with this claim, and kind of NFTs in general, is that all the collectables in general are fake, and all the NFT really does is try to prop up scarcity, which is also fake in this scenario. There's nothing genuine about any of this.

Pokémon cards, back in the day, was at least some cool looking sheets of paper and a game to play. But you can buy a single $100 NFT and pay $200 in "gas fees". That's already exceeded what an average parent probably spent on Pokémon cards per year.
Are you saying "Case numbers! Case numbers! Hospital rates are NEARLY at capacity!!!!" isn't real?
This whole post reads like someone who is frustrated with a new technology they don't understand.

>We should stop building key-management plugins and start thinking about a standardizable web API. We must stop training our users to install shitty browser plugins!

"standardizable web API" is a total pipe dream. The space moves too quickly for standards. Why is installing a browser plugin bad? Is metamask shitty? The millions of MAU must not have noticed.

>We need to make light clients work as soon as possible and become independent from third-party services like thegraph and Infura.

What does this mean? You can use metmask and web3/ethers.js with your own node. When $$$ is on the line (as with Uniswap, et. al.), it makes sense to farm out your infra to someone else. Should we also be moving away from AWS and its reliability / productivity gains to appease the author?

>We need to improve our client libraries (ethers.js and web3.js) by dramatically simplifying them and making them bug-free (god damn it!)!

Yes, first good point of the article. People are working on this. Could be said about ANY technology. Web3 is still VERY early.

>We need to take advantage of some of the blockchain's fundamental properties. Most data is immutable so let's start caching things.

Not sure what this means either. What are we caching? Where? Why? Are you aware we already (kinda) do this with the strata of different ETH nodes via say syncmode in geth? Or are you talking about front ends, many of which are already distributed via IPFS?
I agree that the downvote option is problematic - it carries different meanings with subtle differences:

- A way to signal disagreement with a comment.

- A means to flag a comment as clearly misleading or incorrect.

- A way of signalling a 'low value' comment (obviously subjective).

- A way for the downvoter to simply express his or her displeasure at what has been posted regardless how reasonable the comment is. (This probably happens more often than people care to admit it. It's subtly different than just disagreement.)

One might argue all the above examples are types of 'disagreement'.

An idea: clicking downvote adds the following line to the end of a comment:

1 reader disagrees or 3 readers disagree

It doesn't capture the other examples, but maybe it will deter the other uses.

On the other hand, this might be a terrible idea. It's a difficult problem to solve!