skysight-inc/HackerNews huggingface dataset:
It is inappropriate to critique a drug's studies, and to apply them to the overall drug itself.

"because the studies are flawed, the drug is useless"

A more measured response would be to look through the actual studies themselves, ferret out good from bad, and then to draw conclusions.

Additionally, to ask questions about variables for which we know there are a ton of potential reasons why we'd see differences. Foremost being food/drug synergism, prescription requirements, genetic differences in drug MOA, and variation of actual covid type.

It doesn't refute good studies on ivermectin e.g. "the golden hamster" https://www.embopress.org/doi/full/10.15252/emmm.202114122

Protocols like Zelenko/McCullough do not list any one drug as a "wonder drug" but instead have a large number of drugs and vitamins to treat all the specific indications in more classes of drugs
Years ago I was doing consulting work for a startup, and was able to negotiate a 4 day week. I worked 2 days at a time with Wednesday off.

My next job was as an FTE at another very early stage startup, where we were constantly working and in the office 6 days a week, with some all-nighters before demos etc.

I was vastly more productive during the 4 day week period.
What you could do was embedding the BO exe inside another exe disguised as a jpg picture. When executed it would extract and run BO in the background and also display a jpg. ICQ conveniently didn't display the end of long filenames, so you could send it as "xyz.jpg[20spaces].exe" and it would seem like you just shared a picture. Worked like a charm the one time I tested this technique on an unsuspecting friend during a LAN party.
Yes, not being able to move a piece of plywood (even with the bed down) would completely defeat the purpose of a small truck for me.

I'd rather give up cab space than bed space.
Isn’t “green hydrogen” a sham? I thought the production of it wasn’t actually very CO2 friendly and comes out of fossils fuels themselves?
Not at all. The woke thing is not liberal universalism, because it is actively hostile to any competing ideologies or definitions. That makes it explicitly anti-libertarian.
What are you afraid AI will do?
He made quite beautiful artistic cakes. He offered any other cake than a wedding cake, because other cakes aren't personal.

A mortgage is impersonal, this is more like requiring an LGBTQIA+ artist to paint a picture of Trump against their will.
Neither of those statements is even close to being true.
There is the `hyphens` CSS property [1]. Apparently, all big browsers implement it at least for english. It's a pity though, that this is not possible for other languages (at least for Chrome). It should be as simple as provide a basic dictionary with hyphenation data...

[1] https://developer.mozilla.org/en-US/docs/Web/CSS/hyphens
The other side of it is that it was unnecessarily lambasted and made to seem unscientific when it was being administered by our hospitals.

People would go in Twitter and shout "people promoting HCQ are idiots!" while their grandpa was in the hospital on that very drug as administered by doctors.

Neither side has been entirely rational.
This article is ridiculous. It's claiming that Ivermectin is unsafe because people are taking the horse-intended version... . Really, they're screaming "We're losing money! We wanted to get paid for you taking the unproven vaccine instead of a safe drug that's been around for decades!" The wording in this article is highly dubious "The drug can cause... even death." Oh please! Then how come doctors are prescribing it???? Individual doctors, who have been to medical school, who understand pharmacy and anatomy, are prescribing this drug, and Pfizer is FURIOUS. Pfizer and Faucci likely paid for this article to be written, because one shred of critical thinking "debunks" this fraudulent article.
“They are effective, but doctors need them more, so please don’t hoard” is different from “they are not effective”, hence is a lie.

This should be a lesson to all those corporate-like structures in public sector where they use common enterprise tactics of middle management to say things in the non-specific way so that later down the road they can cover their asses.

They had to be very specific, don’t lie, simply say about things they are not sure about “we don’t know” (hydroxychloroquine, ivermectin etc.) and do tests, never say “vaccines are safe”, but say they are 100000 times less dangerous than disease etc.

And then we could trust every word they just say as we know that they are very aware of what they are saying and they haven’t lied to us in a lot of situations before.

They should govern, but instead they play politics… wtf really.
The fact is: you can't wave a magic wand, and suddenly crap out a person with high-level experience in these very young tools, who also happens to have officer-level rank in the USAF (or at the very least: experience with satisfying the operational and compliance requirements in this industry). I have no doubt such people exist. But not in the numbers that would be needed. It will take years or decades of focused effort to build that workforce.
Thanks for the advice. I’ve actually tried option 1 my manager is in the same boat get along quite well with him and would likely follow him out of the company. Seeing him come up against the same issues is nearly as frustrating.
What’s the difference between those that take drugs based on Facebook posts and those who take drugs based on TV adverts?
Well there was that study published in the Lancet dunking on HCQ using manufactured data that even made it past peer review. This despite the data failing the most basic of smell tests:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
Burning a 0-day exploit on changing people's backgrounds or color scheme would be a good bit in 2021
From my understanding companies projected chip needs months and years in advance but a few things happened.

1. Companies cut their orders expecting less demand and lost their place in line for orders.

2. Because of the rush to work remote so suddenly people needed everything from new computers for kids, monitors and accessories for a home office and in general a lot of stuff that used chips.

3. Because of Covid there were shutdowns at semiconductor manufacturers and even disruptions due to fire and weather.

Suddenly the entire supply chain went into shock, something that had been perfectly balanced between supply and demand was full of uncertainty. Now we have a situation where everyone is begging for chips and they cannot be built fast enough. Essentially the companies are behind on production and the demand is so high they cannot meet it. Everyone keeps predicting an end but it seems that manufacturers are still falling even further behind than they were before.
Geez, I dunno.

If only it was explained in a conveniently linked article.
First, all the predictions went sideways. Consumers needed, not just wanted, more cars and equipment to function as PPE. As their mobile personal protective transit bubbles. As their remote-work conversation devices. As new types of hardware that weren't being used for those economic functions before. Even as webcams and the like.

Second, the quarantines combine with unemployment that frees an abused workforce from abusive conditions. Instead of being wage slaves forced to take any job what-so-ever workers are able to demand jobs that value safety protocols, pay well enough to live in an area (which is also extra insane right now), and have reasonable hours (enough, the right times etc).

Third, (rent) given a combination of working from home, closed 'entertainment' venues, and general quality of life concerns many have decided to flee the high rents of cities for suburban and even rural areas where their money goes farther. This causes more desire to purchase and more wasteful food packaging and production at home as well. Everywhere around me prices have gone up on eating out something like 25% since the start of the pandemic; my wages have not. So instead of eating small portions of bulk shipped and prepared ingredients I'm now eating at home more, mostly frozen stuff. The price of rent didn't quite increase that much but housing is also insane right now, just like even used cars, due to the supply crunch.

Supply correction is how we as a culture, country, and world escape this problem. Increasing supply in all of the problem areas is the only way out.

Supply means buying power goes up, irrespective of wages. Those misguided attempts to raise everyone's minimum wage (tax the middle class, since the elite who own the rentable units will just raise their rates) would work far better by decreasing the cost of a better life. It could also be targeted towards desired resources, growing out of undesired patterns and standards which is also opportunity for better energy efficiency.
It’s convenient that under wokeness, the real bad guys are my white in laws in rural Oregon and not the white people “doing the work” in Wall Street and SV.
> You're incorrect about right and wrong changing over time

Care to elaborate?
I'm a fan of biographies. The first half of Walter Isaacson's Einstein biography fits this. Helped me appreciate how unobvious certain things were prior to discovery.
At university our computer labs were full of SGI Indy's. For most people at the time it was the first computer they'd used with a webcam.

Every student could log into all the machines.... and access the webcam remotely.

Lots of messages to people telling them things like to stop picking their nose when they were sitting somewhere they thought nobody could see them.

People learned to use the privacy shields on the cams very quickly.
I do wonder how much of this is exacerbated by hoarding. Similar to the Great Toilet Paper Shortage, where fear of continued shortages caused panic buying which caused extended shortfall of supply. And that was in an industry where production was not constrained and warehouses were full!
Not sure what you mean. Somewhow this could apply to both the abortion law as well as godaddy.
A lot of the cryptocurrency space is exploring different modes of “governance” today. In the sense of “I have this project which exists on Ethereum, the ecosystem is beginning to build up around it, and I know we’ll have to make changes to the project down the road as the environment changes: how do I discover what will be best for the project, how do I announce those decisions legitimately, and how do I fund the new resulting work?”.

I’m wondering if the author was referring to this use of cryptocurrencies. It’s sad, but a lot of these cryptocurrency projects have implemented much more transparent and frictionless forms of voting than what we have in representative democracies today. You don’t have to search out and then show up to some hours-long meeting about a new construction project: there’s just a public vote, with attached forums for the discussion aspect. Pull up the front governance page and you can see every proposal currently up for vote, and every historical proposal. It’s all there, easily accessible.

If a new city were born which achieved any similar degree of transparency/low friction in their direct governance, I would seriously consider moving to it. There are lots of “if”s there, but LOADS of our problems in cities amount to misaligned incentives, such that they would disappear if only we got the right incentives in place (e.g. NIMBY policies benefit existing high-networth homeowners at the cost of more vulnerable/younger renters. There are ways to balance things such that NIMBYism at least isn’t an economically profitable position to take). Experimentation is the way to discover better incentives, and strong governance is the way to enact/enforce those. Today every city in the country almost universally uses a paper-based representative government. There’s such little experimentation in the physical world at that level that you’d either have to believe that a) we’ve already found & enacted the most effective form of governance or b) there are undiscovered systems which could better meet the needs of modern-day citizens. My money’s on b. And though b doesn’t need cryptocurrency, today’s cryptocurrencies are capable/flexible enough that they could be slotted in for such a purpose far easier than anything else, so why not use them.
>What about COVID caused the shortage? Is it shipping speeds? Change in demand? Less efficiency down the supply chain due to health requirements? Trade changes?

Take a look at "the beer game". One of the lessons from that game is that a single change in consumer demand causes a wide variety of supply chain disruptions. This lesson was learnt in the 1950s and unfortunately it looks like they stopped teaching this in mba schools, so we have to learn it the hard way all over again.

[0] https://www.shmula.com/the-bullwhip-effect/310/
Personally I found most of those examples to be not great. I think they would be improved better names overall, more well named private methods and most importantly well structured companion test classes proving the behavior.

I really dont want to read another developers comments on their mental state while I am feverishly debugging their code during a 3am page.

The number of times I have been misled by an outdated comment. I generally open git blame to see if the comments predate any code now. Tests on the other hand almost never lie.

Readmes or comments explaining why something exists vs what it allegedly does are generally much better. If you can’t write expressive code why would you assume your English is much better?
Art NFTs are trendy but the space is not going away. NFTs are what BTC use to be ten years ago.
If it really were about children's rights, then they would also be all for supporting families economically and putting resources into education. But they do not. The most probable explanation is still control over female reproduction.
Notably, the man who said that is now married to a man himself.
Ask yourself: why does the big photo only show the veterinary version? Why do so many headlines classify it as horse paste medicine? They are fully aware most people only read the headlines or above the fold. They bury mention of human dosage to have plausible deniability, knowing most people won't ever see it.

As for Merck, they are creating a new, patented version for Covid use. They want ivermectin discredited because anyone can make it. This is how that industry operates.
People know when they're being played for fools and if you don't treat them as if they're capable of nuance you will only lose their trust and push them further away.
Lots of festivals before and since burn a wicker man, it has its roots in pagan mythology, but the reasons are probably not complex; they saw others doing it and stole the idea.

https://en.m.wikipedia.org/wiki/Wicker_man
I've had mixed results with that. Sometimes it works flawlessly, sometimes it doesn't.

It should be said that I was mixing that with non-root podman (although that should be a supported usage).

I went back to podman-compose.

Dunno
Amnezia – Your personal self-hosted VPN
To be fair, ivermectin is an old drug with a well established safety record ... when using proper human dosing.

The COVID vaccines are only just getting their first full approvals.

If someone is evaluating the drugs purely on their long term track record of safety, ivermectin wins by a long shot.

But none of that really matters, because the problem is about efficacy. It might be "safer" to take ivermectin in a vacuum than one of the vaccines, but that doesn't matter if ivermectin doesn't protect you and you die of COVID anyway.
Extra packages/steps/incantations that to be performed/installed, introduction of a docker context mechanism that requires understanding, lingering inconsistencies with external filesystem mounting as root owner, incompatibility with most existing docker scripts and compose scripts, confusion on how to get back to root mode, etc.

It just didn't feel like a turn key solution. I have no idea how this would work in CI/CD systems though docker doesn't always need to be as secure there. Docker is a great tool but, like a lot of tech, in the mad rush to market, security was an afterthought and nowhere has it felt more clearly to me than in rootless mode.
I think the technology is very limited but instead it’s overused in cases that shouldn’t. No matter what model is used and how much it’s trained, we have to come to our senses and realize that it will never be perfect and should’t be used everywhere. It’s shudders me to think that this technology is used in legal cases to make life affecting decision that could be absolutely wrong
A corollary is that SQLite is as ubiquitous to structured storage as JavaScript is to programming and it too lacks the exact decimal representation available as DECIMAL(precision, scale) in other SQL engines.

These are not fatal flaws, IMO, just gaps in need of attention.
> - Blame Toyota with their Just In Time inventory management ideas.

Toyota had a stockpile [1] of semiconductors and are only now-ish running into the same supply problems everyone has been since March 2020.

[1] https://www.bloomberg.com/news/articles/2021-04-07/how-toyot...

> But the Tohoku earthquake’s aftermath pushed Toyota to increase flexibility, and the value of inventory Toyota carries has almost doubled since 2011. Speaking at a briefing in February, Toyota Chief Financial Officer Kenta Kon said as part of the company’s business continuity plans, it keeps as many as four months of stock for some crucial components such as chips. Toyota didn’t expect the semiconductor shortage to disrupt production in the near term, he said.
The premise is not flawed. I don't disagree it's possible to build topsoil and add carbon and use nitrogen fixers and cover crops to accumulate soil organic matter and nutrition. It's just not possible to do that and grow an annual crop of any sufficient size.

Carbon consumption happens through soil disturbance but also by natural oxidation and microbial processes in the soil. And some of the carbon in the plant matter is from the soil, as well.

The permaculturists are right that natural spaces are mostly self-regenerative systems. The problem is they don't feed people. At least not beyond hunter gatherer type densities.

Then add on top of that that most market garden type places are consuming quantities of unrenewable peat (potting mixes for transplant or nursery growing) and plastic (silage tarps and landscape fabric for occlusion, nursery pots, greenhouse poly, etc.) and fossil fuels... And large scale cash crop farms have their own rather drastic inputs as well.

Growing crops is extractive. We can fiddle with the parameters of how extractive, but farming needs inputs. So we need to think about where those inputs come from.
The Tool Box – HTTP Request Smuggling Detection Tool
The failure started with the Texas Lege and then the Supreme Court.

BTW you're misusing the terms "script-kiddies" and "hacktivists".
You have to positively demonstrate that a treatment is effective and safe enough to prescribe. It's not enough for something to have not yet been proven not to work. Otherwise, you could sell gumdrops as a cure for cancer, because nobody has proved gumdrops don't cure cancer. Technically true, but not responsible medicine!
It basically means order sufficient parts before starting layout or even before finalizing the schematic. It's not just microcontrollers that are scarce, it's also "dumb" ICs like power management, discrete logic, A/D interface, etc.
It's a two way street, companies have the right to have fixed schedules from their workers to ensure planning and everything else goes smoothly.

It is easier and sustainable to work around four-day work schedules than to give workers the flexibility of changing their hours.

Also of note, laws and regulations around the world differ in what full time means because full time is where the benefits kick in by laws; in other words; if the worker change to part-time, then the entire benefits package can be drastically impacted.

For an example, in many companies in US, if you work less than 40 hours, then companies are not obligated to give you any benefits such as paid time off, health insurance, etc, they can mark you as a contractor and not an employee.

Changing the 40 hours down to 30 hours as full time would not allow the companies to do that. So, I rather have four-day weekend with full benefits first and then part-time would be considered anything less than 30 hours.

Your idea means that it is more likely that the employees get less benefits while still requiring 40 hours work-load as baseline.
The real question is: how many users do I need to get involved and threatening to leave their service to DoS an arbitrary site?
> Or get a second opinion, like a grown-up.

How frequently do you think people consult more than one doctor when they are sick? I know people do it for expensive, chronic conditions like cancer, but I’m guessing that for urgent infections diseases the frequency is vanishingly small.
Why the Global Chip Shortage Is Making It So Hard to Buy a PS5
It is probably more accurate to describe IVM as a safe antiparasitic with well-known antiviral qualities.

However, we don't always know when something has antiviral properties whether it has efficacy or not against a specific virus. That is why a number of studies is a great contributor to determining when it can be of use, or not.
It long predates Rogan's diagnosis. A few countries used it regularly in their treatment as far back as last year, including India.

But it was more of a spaghetti as the wall thing, and it was removed from the protocol back in May.

It has been the cure-they-don't-want-you-to-know-about du juor, overtaking HQC since about March
All you’re doing here is kicking the can down the road by offloading a moral principle to a law that happens to exist in the US. The fact that this law exists doesn’t actually resolve any moral dillema - it just provides a thin excuse to be philosophically lazy.
Well, they should not be taken by humans in any dose to try and treat respiratory problems. If your doctor gives you a prescription of ivermectin to treat some worm problems, knock yourself out, but there's nothing wrong a simple general message "do not take ivermectin just because you thing you want it" - it's a prescription drug, so use only if explicitly, personally advised by a doctor who has looked into your particular problem and decided that this is the right thing for it.