skysight-inc/HackerNews huggingface dataset:
Recursion Pharmaceuticals | Salt Lake City, Utah | Onsite, Full-Time | www.recursionpharma.com/careers

We have raised over $400M to apply machine learning to one of the most unique datasets in existence - over 12 billion images of cells under a huge number of biological and chemical perturbations, generated in our own labs - in order to find treatments for hundreds of diseases. Our long term mission is to decode biology to radically improve lives - we want to understand biology so well that we can fix most things that go wrong in our bodies. Among other awesome folks, Yoshua Bengio is one of our advisors, and helps our ML team come up with novel ways of tackling these problems.

* Engineering Managers: You'll lead one of our 4 new teams and build a positive team environment for our best in class engineers.

* Senior Full Stack Software Engineer: You'll work with biologists to create experiment design tools ensuring experiments are generating high quality data.

* Senior Software Engineer, Data Platform: You'll work with Biologists, Automation Scientists, and Data Scientists to create a platform that allows them to generate and access petabytes of data and deploy new deep learning models into the production data pipeline.

* Senior Software Engineer, Analysis Platform: You'll work with Data Scientists to create a platform that allows them to quickly iterate on novel analyses and research leveraging petabytes of data.

Logistics: Salt Lake City, Utah and 2 new offices opening in Canada. Hiking/running/biking is literally out our back door, and it's half an hour to 6 ski resorts. Great competitive pay, health insurance, 401k, relocation assistance, equity, monthly fitness/wellness stipend, complementary chef-prepared meals everyday, two one-week paid company closures in addition to flexible, generous vacation, 70ft onsite rock climbing wall, commuter benefits, a top-caliber team, and help make a massively positive human impact. Happy to sponsor/extend visas.

Tech:
Data Science: pydata stack (pandas, numpy, scikit-learn, matplotlib, bokeh, tensorflow w/keras, etc), a cluster of GPUs for all your research ideas
Software Engineering: python, clojure[script], javascript, go, react.js, kafka, kubernetes (GKE), GCE, AWS
Our team of 300+ so far: http://www.recursionpharma.com/team
A breathing tube in the rectum could be an alternative to mechanical ventilators
you are saying that like cybercrime was easier to fight than physical heists. That seems like a bad assumption? And I'm in no way a "banks" fan...
This is essentially what minikube does with the virtual box driver
It's got to be something like how much of the population are getting sick. I presume when a disease is endemic you have a fairly steady rate of illness and death taking into account seasonal variation. Whereas right now covid still seems to be spreading quickly through the population and causing large numbers to get sick at once.
SEEKING WORK | Waterloo, ON Canada (UTC-5) | REMOTE ONLY

Software Developer - Infrastructure, 7+ years experience

Backend: Rust, Elixir
DevOps: Kubernetes, AWS
Email: me@praveenperera.com
Availability: 20-25 hrs / week

I'm an expert in cloud native development (DevOps, Kubernetes and AWS).

My main focus is helping companies get the most out of the cloud. What that means depends on the company. It means architecting start ups cloud setup while paying special attention to security and best practises. It also means helping enterprise customers reduce their AWS bills. Other things I've done include, automate infrastructure with tools like CDK and terraform. Building platforms to allow developers and project managers to deploy code without getting the DevOps teams involved. Migrating from GCP to AWS, and much more.

I have lot's of varied experience, in different sectors and roles including: cloud development, front and backend development. As well as expertise with many different languages and frameworks including: Rust, Elixir, Typescript, Elm, ReScript, React/React Native, Phoenix.

Things to checkout:

Currently working on: https://primcloud.com

GitHub: https://github.com/praveenperera

Blog: http://blog.praveenperera.com/

YouTube: https://www.youtube.com/channel/UCm8urFQRWUEGpaDhdvmeYkQ

If you think you can use me for something you can contact me at me@praveenperera.com
The gap emerges because doing everything under is vastly different than doing strategic work across multiple organizations. It's the difference between captaining a small boat versus a super carrier.
By "on rainfall alone", I meant "with no exterior food production". Of course you need land on which grass can grow and sunlight.
The EU is where the legal requirement is.

YouTube isn't asking for this in other territories.
It sounds to me like you probably got a bad unit: I did a simple benchmark of compiling the abcl codebase from scratch and the M1 was significantly faster than my year old desktop with an AMD 3800 and 128G RAM.

https://twitter.com/fwoaroof/status/1330041394019397636?s=21
Location: Maryland, US

Remote: remote only, no travel

Willing to relocate: unlikely

Technologies: Ruby/Rails, Rust, Crystal, C/C++, HTML/CSS, AWS, GCP, Lambda, Docker

Resume/CV: https://sam0x17.dev

email: sam at durosoft dot com

Currently in a full-time CTO position at a YC company but looking for something on the side / some consulting work.
On top of cost-benefit analysis, you will have to explain to everyone whose life trajectory was meaningfully improved by a resource what alternative path you are providing so that future people can also find their way to a better life.
Do you actually think this is at risk of happening?

I understand the argument you are making, but it seems like Amazon is one of the most successful companies ever, and is absolutely printing money.

I'm not saying you are wrong, I just don't know if this reality or whether this is what people wish would be the case for emotional reasons.
Though it may be grammatically correct, I think only the British use the adjective "Californian". In the US we just say "California".
Math is the foundation of sciences which gets the real Nobel, it would be redundant to have it in there.
Y Combinator's Work at a Startup | Everywhere, including remote | Engineering, Product, Design & more | Full Time

YC runs Work at a Startup: https://www.workatastartup.com

One application (takes about 15 minutes) will apply you to over 800 YC companies -- all vetted, well funded and ready to hire. You can also hide your app from specific YC companies, if you want.

YC founders (and some employees) will reach out to you directly about opportunities. You can also browse the directory and reach out directly yourself. See if there's one that fits your domain interest and risk profile. (Some startups on the platform have raised $10M+, have lots of runway, and are actively hiring for engineers.)

If you have questions about the site, want specific suggestions of companies to check out or could use a resume review, email me and I'm happy to help: ryan@ycombinator.com.
What are these other vaccines? are the vaccinations for other coronaviruses? I'm not a biologist so I'm not seeing the connection. Is there reason to believe adding more doses would make the prevention jump from less than a year to a decade?
It's not unusual to get very large numbers of lifetime doses of flu vaccines, and people frequently get quite a few doses of the tetanus vaccine. As far as I know, nothing goes wrong, although I've heard that side effects from tetanus vaccines are more likely if doses are administered too close together.
Docker changes its subscription plans, usage rules, and product line
Can I get a shoutout for my dot matrix printer?
There's more to immunity than the antibodies generated as a short term response to infection or vaccination. Memory cell activity is more important to long term immunity.
Counterpoint:

https://www.pcmag.com/news/gaming-on-surface-book-2-drains-b...
The linked talk specifically complains about everyone building off of Linux, because doing so bakes in a whole bunch of assumptions that are decades old and might not be the best options for today's hardware...
Cumulus | Senior Software Engineer | Cambridge, MA | Onsite/Remote | Full-time/Internship | https://www.linkedin.com/jobs/view/2694707529

Cumulus Digital Systems is building the Internet of Tools platform to transform the industrial workforce to be fully connected and data-driven, significantly improving safety and productivity in maintenance and construction. Our goal is to eliminate accidents caused by poor work quality.

We are looking for a software engineer to help improve our back-end services. You should have a startup mentality, meaning the ability to rapidly pick up new required skills, and be proactive when it comes to project execution. We are looking for a senior software engineer, who has mastered their craft and keeps up-to-date with developments in their field.

Tech: AWS Lambda, DynamoDB, React, React Native

Reach out to us at careers@cumulusds.com
Atom Computing | Software Engineering Manager | Full-Time | Onsite | Berkeley, CA | Visa sponsorship possible

Atom Computing is a fast-growing, venture-backed startup building scalable quantum computers using optically trapped neutral atoms.

Grow and manage our software team and lead all aspects of our software stack development. Our quantum computing system requires a significant amount of software such as drivers to control hardware devices such as lasers, motors, and cameras, an operating system responsible for managing system resources and scheduling jobs, developer platform and user interfaces for scientists, researchers, engineers, and third-party companies to program quantum algorithms and applications for a broad range of use cases. While software development and people management experience are a must, a background in physics is not necessary as long as you are willing to learn on the job.

Stack: Python, Julia, C++, Rust, AWS, PostgreSQL

Apply at https://atom-computing.com/careers
Do you have any source for the claim that any of the vaccines degrade your immune system?
> as effective as the original two-dose shot and prevents for the same duration

We're giving boosters of a vaccine developed against the Beta variant. That's better than nothing. But it's inefficient against Delta.

Pfizer/BioNTech are working on a Delta-specific booster [1]. If we can get approvals rolling faster without compromising safety, it might mean being able to release variant-specific boosters earlier in their transmission cycle.

[1] https://investors.biontech.de/news-releases/news-release-det...
“…Using Laser-Assisted Side-Channel Attacks”
Just to give an idea of how crazy it is here is a list of the synopsys TSMC 7nm cell libraries [1] and of course their are other companies that offer additional cell libraries. Also I have no way of proving this, but I wouldn't be at all surprised if both AMD and Apple have their own customizations or additions to whatever cell library they use.

[1] https://www.synopsys.com/dw/emllselector.php?f=TSMC&n=7&s=r3...
I read 'Islands in the net' a few years ago and thought it was contemporary before I saw it's from 1988 (!!!)...
The Complex Truth About ‘Junk DNA’
Good luck with that in 2021, someone is already making a lot of money, and ostensibly weaponizing big tech into preventing anyone from even talking about alternatives.
I wonder if this is really the case. It seems like the original vaccines trained everyone's immune system on the spike protein specifically because this is exposed and highly conserved by the virus, such that it's hard to change and still leave an effective virus. Delta, however, found such a mutation that made it more virulent and it escaped.

If we vaccinate against the modified spike, it's not clear how many more mutations exist like Delta. Maybe we can still get ahead of it, but I don't think anyone knows yet.

I do wonder if we'll see reformulated boosters against Delta's spikes, though.
The Rise and Fall of ‘ZuckTalk’
Never have all Linux devs worked on anything exclusively.
Seems surprising to me that you can look at financial history and conclude in any way that the Fed is somehow impotent.
In fairness, I think it's been just as frustrating to the health officials setting out those targets— between non-compliance with the initial guidelines (both due to idiocy, and due to governments dragging their heels on the income/rent supports that would have allowed poor people to actually stay home), and then the appearance of the delta variant just as vaccination campaigns were getting seriously under way, I'm sure it has very much felt like fighting a battle against moving goalposts.
That's the point though: large amounts of cash should not be sitting there, they should be circulating through investment. It's not a tax as much as an incentive. Inflation functions the same way by making holding on to cash a losing proposition.

There is just SO MUCH cash right now in the hands of the wealthy classes and it's just sitting there in bank accounts not being circulated.
This is being practiced successfully throughout the world since the Great Depression times. Would love to hear when do you expect this system to collapse?
It relates in the following way. Suppose you have some framework for calculation which depends on matrix multiplications. You use that framework to develop some approximation for matrix multiplications which are faster. Then to make that framework faster, you substitute that back into the framework. That is a sort of bootstrapping which user qsort has related to compiler bootstrapping.

The goal in compiler boostrapping is to reach a fixed point, in a single iteration. When the compiler binary compiles itself, what should come out is a faithful replica of that compiler binary. Having done compiler bootstrapping, I know about hair-pulling problems that occur when you don't have a fixed point. E.g. a bug in the optimization causes the compiler to subtly miscompile itself. The resulting compiler then severely miscompiles itself; e.g. fails to recompile itself entirely, or produces something that no longer runs at all. (And that's actually a lucky case; a compiler compiling itself is basically a dog food test. When that fails, you've caught a bug early. What keeps you awake at night is the compiler compiling itself perfectly fine, but rarely miscompiling other code in the wild.)

Anyway, this sort of malfunction is exactly what will happen if you take a working, self-hosted compiler and then replace some important chunk of it with some hokey machine-learning approximation. It's unlikely you can do that without breaking the fixed point.

I don't see how you can not have fixed point issues in the matrix scenario. Maybe it will stabilize if you iterate on it. You take the machine learning framework with approximate matrix multiplications in it and run the process for figuring out those matrix multiplications. You may get some different values in it, which you can substitute back and try again. Will that converge? If it does, how do you know the whole thing is still valid? (What definition of valid applies?)
Given that you’ve researched it, what laptop brands would you recommend that aren’t made in china?
They mandated it, not just "didn't do anything about it."
Timescale | Full-time | Global Remote | Database, cloud, observability engineers | https://www.timescale.com/careers

TimescaleDB is the leading open-source relational database for time-series data. Fully managed or self‑hosted.

Promscale is the long‑term store for Prometheus data, designed for analytics. Open-source, horizontally scalable, and operationally mature.

We are hiring engineers to fulfil roles in areas of database, cloud, and observability. Multiple roles available. Also looking to hire into non-tech roles.

Timescale operates as a global, fully remote team.

Find out more at our careers page: https://www.timescale.com/careers
I am also not in a Django shop.

But I don't think Django templates are safe in a way that they protect the backend from a clueless or malicious frontend developer. Even if they were, you would have to take great care that you do not expose dangerous functionality. So "give them access to the Django template itself" is not enough. You would have to have a whole security concept around it.

And that is not enough. How does the fronted dev create routes? How do they create views, which are the glue between the DB and the templates?

Node.js is a runtime, not a framework. It does not have routes, views or templates at all. So that comparison makes no sense.

No matter which backend framework you choose - you will have a lot more work to bring the frontend dev into the game if you do backend rendering.

Please be aware that I am not against backend rendering. I indeed think that backend rendering is the better approach! I just explain here why there is some appeal to developers to write the backend as an API and do the rendering on the frontend.
Hello - I'm just over in Louisville myself. Is Lexington as .NET heavy as Louisville? I'd love to switch over to fullstack Typescript + Postgres at some point.
slice | Backend, Full stack engineers | Full-time | Bangalore

slice is India's best credit card challenger to pay bills, manage expenses, and unlock rewards. Our members love us and swear by us. We're reinventing how traditional credit cards work by offering a simple and transparent app to help our members transact easily. We have about 3 million registered members with an average age of 23, making us a market leader in a niche and growing segment.

* We are looking for Backend SDE 2 and 3 engineers who have hands on experience in Node, Express, MongoDB, TypeScript, AWS.

* We are also looking for Engineering Managers who have experience in managing small teams of 5-7 engineers and have experience in Node, Express, MongoDB, TypeScript, AWS.

You can find more openings here: https://careers.sliceit.com/jobs

Note: Please mention that you are applying in reference to this post in HN. :)
I found The Diamond Age: or A Young Lady's Illustrated Primer to be an incredible read, and a great introduction to Neal Stephenson.

Like William Gibson he has a prophetic ability to see future technology, and put it to paper.
I am not a virologist, but based on my reading, in 100 years COVID will still be with us. At worst it will be the flu, and at best it will be just another strain of a cold.

COVID has the very helpful quality of being least impactful on the very young. As new children are born they will be exposed to COVID multiple times over their lives, to the point when they are at ages we now consider vulnerable, they likely will have developed as much resistance as one can have.
Power curves and C-state handling is also performed by the firmware, which is again controlled by the OEM/ODM not the chipmaker.
1) navigation.

2) auto-completion.

3) auto-correction.(JetBrains calls them "intentions".)

4) refactoring (of which renaming is incredibly powerful, and one I once scoffed at before I understood how empowering it is to be able to reliably rename things across the board and have everything continue to work as before, without error. This reminds me, PyCharm still has problems with this. I must make a bug report.)
> Had Patton been given more authority and given less reprimands … the war could very well have ended a year earlier.

The war started because another arsehole was given more authority and less reprimands.

The Enabling Act of 1933 was pitched as a temporary measure to "to Remedy the Distress of People and the Reich""

So no: its never worth giving a chop too much power.

[1] https://www.dw.com/en/the-law-that-enabled-hitlers-dictators...
Oh I was wondering where refold.la came from, since I've never seen it before (which would be unusual for me)

Turns out it's the result of the partnership breakup between Matt and Yoga who used to run Mass Immersion Approach. I was reading the (incomplete guide) and realized it looked familiar.
Math isn't a science at all, nor does it pretend to be.
Vancouver grey
Sadly, I think you may be right. The ship has sailed on a great many channels and videos I had bookmarked. Rescuing whatever we can from this fire and pulling the plug on our own consumption on the platform seems like the wisest course of action.
I see you don't understand. Either it is or it is not lost. By lost I mean unrecoverable with any method because there is not enough information to recover from.

In any photo some detail has been lost. This is trivially proven, as the amount of detail in the actual scene was many, many orders of magnitude more than in the photo file.

Detail that has been lost cannot be recovered, it can only be replaced with something that makes contextual sense which is what AI is doing here.
YouTube-dl doesn't without a proxy but some of the variants do.
Priming is not a theory that generally failed to replicate afaict. There was bad research but priming as a phenomenon is far from "busted".
I am aware of some older studies on marginal utility of money for individuals, but they span quite low income/wealth. I have seen some small data that suggest that at the very least the drop in marginal utility is much weaker than previously thought for high wealth brackets. Do you have some pointers to newer data on UHWIs, for example?

I personally have found that there were times when the marginal utility of my additional wealth was growing as I could suddenly do things I could not do before... (while it other times it almost felt like 0)
Interview w Nathan Latka: Helping companies get cash w / o giving up board seats
As you get older there is diminishing returns on getting better. There is a big difference between someone fresh out of school and been there for 1 year. Between 1 and 2 years it isn't as big, but still important. Between 10 and 20 years there is very little (at 20 years you should have forgotten something that is no longer useful). By 40 years your mind is probably in decline...
> A deterministic algorithm can't generate information where none exists.

Right. All the processes being used for these purposes are stochastic.

Edit: Actually they are deterministic, in the same way a pseudo-random-number-generator is, and typically rely on a 'seed' that would have to come from a random source to be non-deterministic, and doesn't, so users get to have pseudo-random but reproducible results. But that's really getting into the weeds.
Systems software engineer

Location: Eastern US

Remote: Yes

Relocate: No

Technologies: C, C++, Assemblers, FPGAs, Mathematica/Matlab, Python, Java. I have worked on performance optimization, hardware/software co-design, parallel (SIMD + hardware accelerated) algorithms, numerical analysis, time synchronization, and advanced networking (eg XDP, DPDK).

Resume: Available on request (6 YoE, currently Senior Software Eng @ big tech)

Email: pclmulqdq@fastmail.com

-----

Hi everyone! I am a software and hardware engineer based in the Eastern US. I am looking for a small, remote-friendly company for my next role, preferably where I can work on performance optimization or products related to foundational technologies. Contracts possible.
> Is there any reason not to increase vaccine production rates so we have the capacity to vaccinate the world population faster than every 9 months?

Capital constraints. Most specifically, human capital. mRNA production methods, including for critical precursors, are complicated. There is a limited number of people who can build and monitor the productions systems.