skysight-inc/HackerNews huggingface dataset:
Because it means rerunning the trials again.

These requirements will have to be loosened for anti-Covid vaccines. They are tailored to other diseases, but SARS-CoV-2 mutates too fast. The flu vaccine has an exception, too, otherwise it wouldn't be possible to prepare the correct vaccine (against the expected dominant strain) on time.
But thre are literally millions of fast food restaurants to choose from, accessible to everyone.

In mobile space, we basically have two OSes with their default browsers and search engine, and in browser space we have three, and all of them basically use one of the two search engines (and their derivatives).
Because steroids attack the bone? And suppress the imune system and everything is connected with everything..
It's discussed fairly early in the article.
Issue opened!

https://github.com/evidence-dev/evidence/issues/94
I was going to list some use cases individually, but you can get a better picture by skimming through this: https://github.com/awesome-selfhosted/awesome-selfhosted

It's rare that a self-hosted piece of software is not present on this list. As you can see, the coverage is pretty extensive.
We really just need to leave fossil fuels in the ground starting right now. Capture is good, and probably necessary, but we'll be fighting a losing, impossible battle until we stop emitting. Non-damaging energy technology is right there, we only need to use it.
What makes them not vaccines?
Texas and Florida together account for 15% of the US population, but 30% of the hospitalizations.
I actually like /r/thenetherlands.

You're question does seem too meta and pointless. It's just a sub about Dutch news and stuff.
Yes, Twitter arbitrarily censors people for expressing the wrong views. Yes, the censorship fails. People who understand the idea of free expression feel deep revulsion at censorship. To me, something being censored is enough of a reason to look at it and to help it spread.

> “Right now, the only way we have to deal with content is on a platform-by-platform basis.”

Oh, that's so sad, isn't it? If only there were a way to conveniently and pervasively stamp out all that dirty "misinformation". Come on -- aren't you supposed to at least make your authoritarian tendencies somewhat subtle?

> Even if Trump runs for president and wins in 2024, Twitter said it would not reinstate him.

The Taliban's various accounts are safe, though.
Even if you took away all controversy and politics, I hate Reddit. The search function sucks. They shoved their own harebrained video player down everyone’s throats and it constantly plays by itself without opening. And when you do open it it doesn’t fucking play half the time. They also foisted their eye-bleeding updated user interface upon our innocent souls and forever corrupted us. It can only be described as Fischer price from hell. And also the idea of Reddit sucks on a structural level. There are tons of subs that are cool but too narrow to gain a large following. They can’t fill in the template subreddit community. You see overly specific subreddits like “praise the camera man” or “public freak outs” or “woah dude” and they invariably all cycle through the same videos and pictures, the ones getting the most traction, violating the whole premise of having specific communities. It should have been something like you can tag a post “woah dude” or “videos that end too soon” and just submit it to the universal page. People could still track tags of interest and do everything without the whole mess and insanity of subreddits and also without assholes turning subreddits into little fiefdoms.
But web applications don't have all my data. I gave you an example just above - Discord web app can't see what other programs I have running. Discord Desktop can. Google docs can read all my data on Google Docs (shocking), but Microsoft Word could be stealing my cookies from my browser and accessing my Google Docs, my iCloud and anything else too.

You keep making these bombastic statements with no data behind. Not all web applications store every page interaction into a marketing engine. For example, I have a web application - as you navigate no additional network requests are sent (it's SPA!), and anyway I don't really have access to those the server logs because they're hosted by some Netlify-like service. See? Web application without you data that doesn't feed your interactions into a marketing engine.

Some web apps track, some desktop apps track. But clearly and without any doubt an executable running in your operating system can potential do much more than a web app you open with your up-to-date browser. An executable can even... open a web app!
Emphasis should be on tick-bite prevention. I have never had live tick on me and have been literally wallowing on all tick-infested areas of northern hemisphere. They just die. Most probably just drop off, but sometimes there is dead tick only slightly attached. Looks like they die on first drop of blood.
> The big difference is that it comes preinstalled. If you had a whole company on MacBooks but not all of them had Node installed, and you wanted to distribute a script written in JavaScript, this could be handy

Except when Apple decides to remove it from the default setup.
I think our approval processes haven't kept up with the technology. The existing vaccine is already approved, and boosters seem to have some beneficial affects.
Note that is actually in the page, is NOT the ad, and couldn't have been injected by the ad.

It looks troublesome to me, as I don't see it on other similar pages on your site that also have ads.

Edit: Confirmed. Added "optyruntchan.com" to my local hosts file as 127.0.0.1. The page still has the ad at the bottom, but all the popups, overlays, redirects, are gone.
Voice chat. It is superior to any other platform on this aspect other than TeamSpeak. We regularly have 40+ people in voice channels without people suffering from connection issues, bad audio quality, and lot's of noise.
We need to remove gigatons of carbon from the atmosphere, and we don't have anywhere to put that much stuff. It's a bit of a pipe dream.

The only real path to avoiding the worst effects of climate change is stopping emissions.
15% of the population has 31% of hospitalizations.

Definitely a "surprise".
I'm sure the FDA is on it, but what about psychosomatic effects?
And how is that different from the persoective of an employee?
Natural selection will quickly weed out everyone who tries to follow the suggested path. Simply due to cost of traffic becoming lower than revenue.
None of that describes selling data to third parties. The third parties that might receive data as described in this section are vendors or partners, not customers. Apple isn't making money off the sale of data here.
That's incorrect. They are vaccines even while working differently.

The body develops immunity in reaction to the spike proteins that it produced itself after turning the mRNA instructions contained in the vaccine into proteins (namely the spike proteins that the SARS-Cov2 virus uses to enter cells).

Ribosomes, tiny and amazing molecular machines, read this mRNA and produce the encoded sequence of aminoacids. With every reading, a bit of the tail of the mRNA sequence gets used up and once it's too short, the whole sequence is broken down. That means the mRNA in the vaccine gets used up with time.

The mRNA never makes it into the nucleus where your DNA resides.

Ribosomes are interesting btw, you can read about them here:

https://en.wikipedia.org/wiki/Ribosome
The states with the low vaccination rates are now paying the price of their politics.
U.S. plans Covid booster shots at six months instead of eight
> It feels like Java sort of tried to be this, as did .NET

I meant compile your whole logic and libraries into one (big) binary so you won't depend on any runtime that might ever change except for your operating systems syscalls.

> most ways to encapsulate scripts in static binaries fail miserably [...] and otherwise there aren't too many technologies that are good for this out there.

LUA is about as stable as it gets, (minimal) WASM runtimes will also probably live forever. (Or are, most likely, interchangeable if not) For both of them you'll need to build the interface yourself, so any breaking change will at least be your own fault.

> Any other options that you can think of?

Rust, or if you are a bit masochistic C or even C++. Rocket 0.5 (Rust) looks really nice (as in ergonomic) as a webserver and iirc you can statically link with musl instead of glibc.

> I'd say that it's only a question of time until Apache/Nginx/Traefik + Certbot run into similar issues

But then youll at least have http as a fallback

> So sadly if i get hit by a bus tomorrow, it's only a matter of time until my homepage stops functioning and the memory of me disappears forever.

I think what you want is a trust fund :D
> just seems like a lot of unpaid mundane and never ending work.

Some subs like /r/politics and /r/news appear to be ran by the Democratic Party... Would it public be public data if they used party funds to moderate them?
It's not individual numbers that matter, but the properties of sets of them and functions over them. You can define a Reimann integral over computable numbers without changing much, but not the more general Lebesgue integral. This means you won't get e.g. the nice properties of L2 spaces which are used heavily in quantum mechanics.
> any non-Americans its always important to put this in the context that "waiving" here means you're still paying thousands per month (between employer and individual) in premiums and likely hundreds in various flavors of co-jargons anytime you step the foot in the door of a care provider even for "covered" care.

Where did you come up with “thousands” and “likely hundreds”?

Just so the non-Americans reading this have a data point, I’m a single person with Type 1 diabetes who pays $200 a month for my insurance premium (my employer also pays $200 a month). I also pay about $110 a month out of pocket for insulin, $1500ish a year for my glucose monitor, and pay about $250 total a year in various co-pays to see a primary care physician, endocrinologist, and ophthalmologist (maybe 6-7 visits total. This is on a “Gold” plan (the best offered by my employer).
That thread from 2018 refers to RFC 5966 which was obsoleted by RFC 7766 in 2016. RFC 7766 is much stricter saying TCP support is required. https://datatracker.ietf.org/doc/html/rfc7766#section-5
Oh another mandatory money flow stream incoming!
Get your mRNA vax card now folks.
It probably made sense in 1983.

https://github.com/dank101/4.2BSD/blob/master/include/netdb....
HIV was a few days ago. Amazing if it works.
https://gizmodo.com/moderna-set-to-test-experimental-hiv-mrn...
I’d be much more interested in an analysis of Threes!
One of the specific government programs set up for that purpose. https://www.hrsa.gov/cicp
Technically, anything but doctor Jenner's original vaccine against smallpox, which was derived from cowpox, isn't a vaccine. Vacca is literally cow in Latin and vaccine means from cows, which the other vaccines aren't.

But that would be silly, right?
On the contrary, something very obvious stops workers from buying enough shares to appoint someone to the board: access to capital. What you say is true in theory, I suppose, but is far from true in practice for any reasonably-sized publicly-traded company. How can an average worker at Walmart practically voice any opinion via shares?
My old boss had multiple profiles sort of curated around topics said that it was a bit of hassle to set up but worked really well for him.
Not the vaccine. Some ticks now transmit the allergen and cause the allergy in humans:

https://en.wikipedia.org/wiki/Alpha-gal_allergy
I didn't say margin, I said profit, and you can click a tab over on any of those pages and see overall gross profit is up in 2020. What kind of rational baseline is assuming that increasing margin is the default neutral state? How is that a stable dynamic for any system?
Yet, it's fairly reliable in most developed countries. So how will a developing country, well, develop, if it can't build a consistent, reliable power grid?
One bad autoimmune reaction from a poorly engineered vaccine and the whole society will boycott the mRNA vaccines forever after. Safety is higher priority to ongoing viability than speed.
Or just buy a laser printer and never have the issue again?
The online platforms that were supposed to provide us a democratic free space to communicate are in fact governed by a tyrannical and unaccountable minority. We see the same situation on Facebook with group moderators and on Twitter (albeit less so) with high follower count blue-check accounts. Not to mention the companies themselves having the power to ban any speech they want.
From my understanding,

size: float = None

is syntactic sugar for

size: Optional[float]
Based on how much my little girl’s ICU admission cost,

https://kingsley.sh/posts/2021/two-weeks-in-the-icu-as-a-bab...

there is no way (in my mind) that their ICU admission will be free.
There are millions of websites to choose from. The best (most convenient to reach) places in cites or on highways will be the big chains.
Curious - what currently unrecognized side-effects are we talking about here?
The law of conservation of energy applies here. You can't make a gigaton of CO2 weigh any less than a billion tons.
Should we assume we are safe if we go hiking in a place where we never brushed against any plants or grass or twigs? In other words we went through woods but only stayed on wide open trails. I assume ticks don’t “fly” in the air ?
"Lisa Shaw, who worked for BBC Radio Newcastle, died at the age of 44 in May after developing headaches a week after getting her first dose of the vaccine.

Newcastle coroner Karen Dilks heard Ms Shaw suffered blood clots in the brain which ultimately led to her death.
The inquest heard the condition linked to the AstraZeneca vaccine was very rare.

The coroner said: "Lisa died due to complications of an AstraZeneca Covid vaccination."

Ms Dilks said Ms Shaw was previously fit and well but concluded that it was "clearly established" that her death was due to a very rare "vaccine-induced thrombotic thrombocytopenia", a condition which leads to swelling and bleeding of the brain."

https://www.bbc.com/news/uk-england-tyne-58330796
Old news, unfortunately: https://old.reddit.com/r/therewasanattempt/comments/gk0w4c/t...
This is Phase 2, but I wonder how long Phase 3 will take, given that getting Lyme disease is still pretty rare, can easily be missed or misdiagnosed, it will takes a lot of time and people to get a significant effect between a control group and vaccinated people
Power Law is everywhere, even where you least expect it.
Uh oh. I was worried they might start messing with GDPR. While GDPR can get complicated to comply with, it is a measure that I wholeheartedly support as a user who values their personal data.
I took this path. Unfortunately I couldn’t get myself into programming and ended in IT. I’m pretty decent and now I’m boxed in IT because I have no “real” experience developing software, but I have a great deal of IT experience. So I’m being offered management positions in IT when what I want is entry level dev lol!

I totally agree with having a different perspective when studying vs when I was 18. I see professors as other adults and not as “the guy I’m afraid of/I want to please/I hate”. I see school as something I chose and not something that life just put in front of me.

However I wish I could find that apprenticeship programming position you mention. I have enough savings to take a pay cut and dedicate myself fully. I feel like now that I’m more mature, if someone were to put me under their wing I’d take off rather quickly, but I haven’t found that yet.
The vaccine does unfortunately not work as well as hoped for in the case of the delta variant + a lot of people are still unvaccinated and delta is much more infectious. Cases and hospitalisations are also up in Israel https://graphics.reuters.com/world-coronavirus-tracker-and-m.... Here is a corresponding news item in Science: https://www.sciencemag.org/news/2021/08/grim-warning-israel-.... It also suggests that the protection against hospitalisation of the vaccine is not as good as it was hoped for among older people. From the publicly available data for Israel you can estimate the vaccine efficacy against hospitalisations to be ~59% (relative risk reduction).
I had a similar experience with my mom who I didn't had too much contact last years. I moved to another country and we talked less frequently that we should. She was an active writer, mostly on facebook and blog (she was blogging consistently since 2001). Now those are the media that I'm using to keep my mom image alive to my kids. She passed on January. I sent her a package for Christmas with some pictures and texts produced by me and my kids. The package came back, probably because it arrived after she was already dead. Now the package is seating near my computer untouched since weeks.
We live in a power law universe
Meta drama started here too..

seriously both sides in Indian politics are so infantile.
Did you read what the service does? You probably don't need hourly snapshots backed up to S3, monitoring and replication if you are hosting MySQL on your local system. This looks to be more like setting up a managed service for production without paying the hosting provider for the extras.
Design Systems Job Board
This article is globally so true, but there is a major error:

It is not "needs of developers" the problem, but the "needs of product manager, marketing, c-level asshole".

Like for telemetry, most of the time the business side "can", so they do.

And again, for specific app and co, most developer would complain and not like release such user-hostile software but they are forced by business to do it.

Like this stupid project manager that thinks that his product/software is the most important in the world and there is no reason why a random user would not want to install it and also that the user computer belongs to him and to the company because he is using the product, without shame.
but a stable forest is carbon neutral. The actual removal occurs when you cut the large trees and bury their wood in deep mines.
It's a nice dream.
Orange you glad I didn't say banana?
had generally good experience creating typed wrappers for api's with json-schema-to-pydantic[0] converter

[0] https://github.com/koxudaxi/datamodel-code-generator
I presume they are reducing the employer contribution towards premiums instead of raising premiums (which they can’t do).
Pandas-stubs – How we enhanced pandas with type annotations
The post correctly argues that linking across systems is unwise and unsound, but in making the argument it shows how valuable a consistent ABI is.
Haven’t they been open for most of the year?

I know people would love to see them fail, but the fact the wave randomly hits them now shows the lack of correlation with restrictions and masks, no?

Wasn’t California topping the charts at points this year?
The point is that new generations can disrupt the market and make money too.
I have never heard of a business that reaches $x of profit and then switches to pricing everything so that they get $0 of profit.

And why would I be concerned with gross margin? If insurance companies were profiting more than normal from COVID, then it would show up in the profit margin figure.
There already are compulsory licensing schemes that work like this. For example, in the United States, there are “mechanical licenses” [1] available by statute for streaming and downloaded music recordings. In practice, most big platforms negotiate with a rights organization or with the artist directly[2], but the statutory rate operates as a price ceiling.

One big problem with compulsory licensing is that rights organizations that manage the payment of royalties often become very powerful themselves and are sometimes seen as copyright bullies. For example, ASCAP, which represents composers and licenses musical compositions rights, pursued the Girl Scouts for unlicensed singing of campfire songs. [3]

[1]: https://www.copyright.gov/licensing/m200a.pdf

[2] example: https://www.theguardian.com/business/2018/nov/24/taylor-swif...

[3]: https://www.nytimes.com/1996/12/17/nyregion/ascap-asks-royal...
I actually had Lyme disease when i was younger. Curiously enough, i didn't get the somewhat common rash after the tick bite, but instead it was discovered later, as a part of blood testing. I was submitted to that after my relatives had concerns about how lethargic i was being, as well as because i was experiencing joint pain, which the blood test later seemed to confirm.

If i recall correctly, i was given antibiotics and felt pretty bad for a month onwards, though nowadays i'm not aware of any lingering long term effects, apart from maybe my short term memory being slightly worse than i'd expect it to. Of course, i think that in my case i had it pretty easy, since some other folks are known to develop symptoms that are considerably more worse. Whether there will be any lingering consequences in my future because of it, only time will tell.

A vaccine would definitely be welcome, especially because of how common ticks are here in Eastern Europe - any walk in the forest might end with more than one of them on your clothes. If you have dogs, you'll probably have to remove dozens of those from their fur every summer.
One of the things I really miss in more business focused apps is the radio style push to talk. It is so much more intuitive than muting.
It's always worked for me. I've never used a bouncer. Maybe the "one thing" is not what you think it is. Think of it like a real room. When you're in the room you hear what's going on. When you're not, you don't.
I think the term you're looking for is capitalize. Pfizer made some investments in a technology that had wide applications, and now they want to capitalize on it. It's good business, and a lot of people are going to be helped in the process.
Lyme is not rare, the CDC estimates 476,000 cases per year in the US. https://www.cdc.gov/lyme/stats/humancases.html
I love Pfizer. They censor the entire internet and fuck up the world.
That's perfectly HN-y; good read, thank you.
I actually find this fascinating as it puts a dollar figure on it.

It’s similar to the FDA priority voucher market. If you get a drug approved by the FDA for a neglected disease, you get a transferable voucher that gets you a priority FDA review for whatever drug you use it for. It might accelerate approval by 3-6 months.

What’s that worth? Well the vouchers have sold for $100-250M lately.

https://www.fiercepharma.com/pharma/sanofi-nets-valuable-fda...
If you want users to pay for your software, put a price on it, and stop pretending it's free. Nagging pop-ups -> Close tab.
A desire to avoid being called anti-vax.
Absolutely not correct. They do work exactly like conventional vector vaccines, the only difference is how the genetic material of the foreign virus is delivered to the cells of the patient. The genetic material of the patient (the genes) is not modified.
In a state that decided the 2000 election by like 500 votes, too.
> Apple isn't making money off the sale of data here.

There's zero mention of that in the aforementioned policy. This policy completely allows them to make money in their deals with their «partners» or even their «service providers» and you wouldn't know it.

For instance, Apple pay is a payment service and I would be really surprised if they didn't get paid by their partner for every transaction made through them. (And yes, a transaction is «personal data»).

And since they are a for profit company, they obviously intend to make money (even if it's not through their partner paying them directly but through indirect revenue sources like customer retention or acquisition) when making partnership, because otherwise they wouldn't make such partnerships!