skysight-inc/HackerNews huggingface dataset:
No, it’s not meaningless. That’s hyperbole and a misunderstanding of what’s going on.

That story was all over the headlines not because it was normal. It was in headlines, and in the front of your mind, because it was the exception that proves the rule. That’s not typical.

Regardless, the FDA approval was mostly about assessing safety of the drug in controlled trials and follow-ups. Likewise, the vaccine studies were rigorous examinations of safety and an in-depth search for warning signs that might indicate problems in small populations. The correct interpretation of this approval is to see that it has been thoroughly examined for safety in the field.

Finally, we already have mountains of evidence that the vaccine is effective. That much is not in question after administering an incredible number of doses globally and observing the outcomes. Proving efficacy was the least of the FDA’s concerns at this point.
To look at that Alzheimer's approval and then conclude that FDA approval is mostly meaningless is a pretty strong statement based off of that alone. Even if you add in high profile drugs that were approved and later were shown to cause huge problems, it still doesn't make FDA approval meaningless. It's pretty hard to get a drug to be FDA approved and means quite a bit.
Are you claiming this is good or bad?

By comparison, in some years the influenza vaccine is under 40% effective. 0.9 deaths per 1 million is amazing (especially given the likely age profile).

See https://www.webmd.com/lung/news/20200902/how-effective-is-th... for some information about the flu vaccine.

In April the vaccination rate was much lower. In a hypothetical situation where 100% of people are vaccinated, all Covid deaths will be vaccinated people.

With so small numbers if vaccinated people dying we should expect that deaths per million to jump around depending on regional outbreaks for a while.
In the hands of a master like Plato, this style is heuristic; that is, it allows the reader, indeed leads him, to discover things for himself.
[...]
"A master like Plato," we said - but there is no one "like" Plato. Other philosophers have attempted dialogues - for example, Cicero and Berkeley - but with little success. Their dialogues are flat, dull, almost unreadable. It is a measure of the greatness of Plato that he was able to write philosophical dialogues that, for wit, charm, and profundity are the equal of any books ever produced by anyone, on any subject. Yet it may be a sign of the inappropriateness of this style of philosophizing that no one except Plato has ever been able to handle it effectively.

Mortimer Adler
This is not the first mRNA vaccine. It's the first to reach full approval, but we've been testing them in humans for a decade now. https://ec.europa.eu/research-and-innovation/en/horizon-maga...
Well, good luck setting up even a Joe Schmoe Email Services Company whose email is deliverable.

In the other HN thread about self-hosted email I've heard it essentially amounts to paying for racket protection so the big players don't "oops we accidentally blacklisted you, good luck trying to rectify that" you.
> Python is much better as 'general purpose' right now

Python has lots of its own problems. Specifically, its type system, performance, and package management are all awful.

> Why would you ship with node_modules? ALWAYS use npm install. If you don't trust npm, the use something like CodeArtifact, but oh my, don't compress dependencies.

You've certainly convinced me that Deno's single binary deployment is a useful feature.
“It’s not FDA approved,” is a secondary objection aimed at urging someone think about the primary.
It wasn't an excuse. It was just the easiest way to get street preachers on a power trip to bugger off
Are you suggesting that it is only useful to criminals? I am surprised you did not even mention the poor on 3rd world countries - unless this is too, a marketing stunt by the crypto community.
I believe the Washington state gas tax charged to standard internal combustion vehicles is much a lot about volume + mass; moving more stuff around less efficiently is going to inherently take more calories & therefore more tax will be paid.

That said, I've been really disappointed with the way the Washington state EV tax you reference was implemented. I mean, I'm just fine paying my fair share, but I should be taxed in the same manner as any other user of the same resources.

To that end, we have vehicle inspection stations & using those to check odometer readings on an annual basis would make for fair taxation.

As it is, I stopped paying registration, insurance and left our Leaf sitting in the driveway since the pandemic started because of the way this tax is levied.
>> Secure by default. No file, network, or environment access, unless explicitly enabled.

> Great, but we're talking about server software so the first thing any project is going
> to do is enable all of that. And it's not like you can trust this on the server, you'd
> still need to sandbox to process if you truly want isolation.

These are not intended to be quick fixes for the masses nor replace sandboxes. They contribute to strength in depth and frustrate attackers looking to make pivots. I'd recommend taking some time to consider the threat models that these measures are align to.

There is evidence that making changes like this contributes to the overall security of an ecosystem. You have a smaller percentage of people who will go ahead and do the wrong thing initially (if you support them with proper guidance), but it's only over time that you have projects based on the platform. More importantly, a change is being made that can sustain a culture of security over the long-term.

When you have to maintain systems that aren't built on platforms with support for measures like these it becomes difficult to retrofit any meaningful level of security, or there is too much obfuscation in the system to justify improving it without rewriting it. Here you can see that the original implementers have enabled privileges unnecessarily and there is a clear angle of attack. Along the way you can also revert all other kinds of bad practices and hacks that previous developers implemented (random calls to external services you don't expect, loading configs from disk that should be loaded another way, etc.) These are not uncommon experiences when technology gets into the hands of the mainstream.
Right, now go and downvote an accurate explanation of how a baseless accusation ("you claimed eight million deaths") is wrong.

Also, just saw this:

> Net implies you are counting positives and subtracting negatives.

That is incorrect.

See https://www.google.com/search?q=define%3Anet

> 1 : free from all charges or deductions: such as. a : remaining after the deduction of all charges, outlay, or loss net earnings net worth — compare gross. b : excluding all tare net weight. 2 : excluding all nonessential considerations : basic, final the net result net effect.

Note (2): "excluding all nonessential considerations". In calculating the rate of deaths from Covid19 among those who are fully vaccinated against Covid19, the people who were infected from Covid19 but did not die from it is "nonessential consideration".

There is nothing wrong with using "net" here. Don't hang your hat on it.

If anyone is willing to think, the increasing rate is problematic, because, naturally, there is a lag between when one is vaccinated and infected. Another lag between infection and hospitalization. Another lag between hospitalization and death.

Update: CDC just updated the numbers. The rate of death from Covid19 among those fully vaccinated against Covid19 now stands at 8.6/million. Deleting previous comments about updates not being made.

> compare current deaths of vaccinated individuals vs unvaccinated individuals

That'd be a nice change from the cumulative totals everyone is using. Do you know where I can find those data?

Also, note that the people who haven't yet had their second shot or people whose second shot was less than two weeks ago are counted as "unvaccinated".

> Your math is pointless.

It would only be pointless if we didn't care about correctly estimating the risk of serious illness or hospitalization from Covid19 among the fully vaccinated.

Given the entirety of the current information, it is reasonable to believe that people who's at greatest risk for suffering seriously or die from Covid19 are going to be in that situation with or without a vaccine.
Thanks, I still want to check out an HHKB JP eventually, both of my HHKBs have the “noisy spacebar” issue unless you flip it around backwards.
Again with this argument. This particular decision with their bodies is harming others. Getting really drunk and driving home is also a decision about your body. So is smoking inside restaurants. Those have been illegal for a while.

For those of us who got the vaccine, we’re still having to take precautions because of the delta variant spikes, largely from people who didn’t get a vaccine. Where is our choice?
> I’m wondering what the odds are that people will pivot from “it’s experimental” to “it was rushed due to politics/greed”.

Or maybe just stick with the fact that it isn't very effective. [1]

[1] https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v...
I stopped using mine when I installed their software that requires login to use the mouse 2 extra buttons. It was brand new.
Counterpoint: I have an old ThinkPad, known for good compatibility. WiFi and sleep work great. Bluetooth? Not so much. It works, but I get lots of random disconnections, after which I may or may not be able to reconnect.
> Perhaps the 250 attendees can decide if they want to be there in person or remotely, why would you remove that choice from the person giving the lecture?

If the lecturer is remote, then the 250 attendees don't have the choice to be there in person.
There needs to be science on this. Some way to quantitatively measure the performance of programmers who do competitive programming and to measure ones that don't.

Until then everyone will agree or disagree but some science will prove a definitive answer. It is very much worth doing such science given the prevalence of testing a programmer for such competitive skills and the fact that many consider such skills useless against the actual daily tasks of a programmer.
> ...by using Electron for their driver.

Except they didn't use Electron for the driver. They used it for the management UI.

> I'm sure that allowed them to iterate quickly, hire developers who know nothing but JS to build their driver package and ship the MVP with low costs!

Pffft. Imagine thinking that people who choose Electron only know JS. Clearly that's incorrect as many companies choose Electron despite employing a multitude of native programmers. I'm one of them.

Personally, I know C, C++, C#, Go, JavaScript, Python, TypeScript, SQL, Swift and Visual Basic...and I'll choose Electron to build GUIs every time. I also use React Native to build mobile apps. Pure native kits all suck compared to Electron or React Native and on top of their pure suckage you'll have to deal with the idiosyncrasies of each platform you deploy to.

I don't just build them either. I run multiple instances of about 4-5 different Electron apps all day long without issue on an i7-4770, a CPU that was released in 2013, inside of an old refurbished machine from like 2014 or 2015. And that's under XFCE most of the day...but when do I go use my Mac or Windows machines I get the same exact experience from those apps thanks to Electron.

But oh no! 300mb!! Unneeded code on my precious hard drive!

Maybe stop whining and get a bigger hard drive if you can't handle 300mb. And I doubt you've actually looked into many of the native desktop apps that you're running to investigate how much of the code is actually necessary. Let's hear some of the great native apps that you run.

What kind of work do you? I really want to hear about the 100% efficient native-only apps.
From the Article:

What I actually learned is that if something is right, it’s right. Context makes a slight difference but fundamental principles hold true. There are laws of nature.

The article isn't suggesting militarizing start ups - it's providing some context on which elements of the military officer selection process are transferable to the start up co-founder selection process.

edit: clarity
I think you're over-simplifying the Alzheimer's treatment. The medicine was shown to be effective in reducing plaques, and has been approved for any medical use where reducing plaques is the goal. However, reducing plaques does not seem to actually help patients with Alzheimer's. So the medicine "works" in the sense that it does what it's supposed to (reduce plaques) but does not help Alzheimer's patient outcomes and should not be used for that purpose. The FDA made the bone-headed decision to let the medicine get its seal of approval anyway, knowing full well that every doctor in the USA would prescribe it anyway.
Vive la paperasse ;)

It varies by metropole. Here in Nice it seems straightforward.
Paging @FSD_in_6m
Facebook,amazon, twitter, youtube and google are free/cheap to hundreds of millions of users. If they started offering the same customer service that utilities, offer presumably prices would have to go up a lot? My solution: get off google and other platforms. I use proton mail. Use duckduckgo (even though it may not be as good as google at finding things). use Instagram (which although owned by Facebook is not as heavily censored). Use substack instead of blogger. Also, do not question the official media narrative about covid or the 2020 election. Doing that will get your accounts killed fast. make sure your covid and vaccine posts are compliant with the CDC and WHO
That's a really extraordinary claim with no evidence whatsoever.
> That story was all over the headlines not because it was normal.

It was in the headlines because it is normal, and some people were trying to improve the system but they failed. There are tons of existing drugs that have been approved based on surrogate endpoints, e.g. iirc the entire class of statin drugs.
Ownership doesn't exist in a vacuum. You need laws and rights, which requires courts to adjudicate and police/military to enforce; and that in turn requires trust in a governing state actor.

For NFTs specifically, you still have to trust whatever chain and transaction says you actually own it. And there's nothing that stops someone else from also claiming they own the original except for the centralized statement of the originating party; nevermind the fact that digital bytes have no "original" anyway.
> It's native as in supported directly by the company making the software.

Except for the times when that isn't true. Elsewhere in this thread people are complaining about how the Logitech software is Electron based but doesn't work on Linux.

> It turns out RAM and disk space are really, REALLY, REALLY fucking cheap.

RAM and disk may be cheap and plentiful, but battery power and bandwidth are not. It's why web apps don't make much sense for mobile today.
I'm not aware of anywhere in the US requiring it for groceries.

NYC is notable for requiring it for indoor dining, gyms, and a few others. https://www.nytimes.com/2021/08/03/nyregion/nyc-vaccine-mand...
Sorry, all Hogwild does is remove locks. It still needs constant global communication (global shared memory is assumed in the paper). That's not embarrassingly parallel.
Yes, because law enforcement would want tens of thousands of vehicles disabled in the roadways to obstruct their ability to do anything.
These cheap shots or trench war between both sides does nobody any good, it divides people instead of unite them.

For me the major issue with the vaccine is the extremely fast track from inventing it to getting it out the door.

An FDA approval will not change my mind on the safety of the vaccine, only time can do that.

By that i mean that we need more time to assess the long-term effects, something that many pro-vaccine people seem unwilling to accept. That is unfortunate.
How climate change is making parts of the world too hot and humid to survive
I'm not quite sure how to take your comment, I think it's meant sarcastically? Note the bit the the asterisk was on was me saying it sounds deliberately racist. And I said assuming it was true and that it doesn't matter if it isn't because it can be how she feels generally or on other occasions.

Maybe I'm getting the wrong end of the stick, but it seems like you're reacting as though I said 'no way, didn't happen, she's a liar, nobody was racist to her, racism doesn't exist'(?) - which is not at all what I said.
More like being inundated by smoke. My town is currently experiencing intermittent days of smokiness from fires burning 100s of miles away. People are dying in those fires. Homes are being destroyed.

But the local fire department isn't doing anything about it. Nobody around here is installing sprinklers as a precaution. They act like there is no fire at all.

Covid is a serious thing. But "engulfed by flames" is the exact overstatement that causes people to question the motivation of fear-mongers.

I'm vaccinated. I wear a mask. I think too many people are whipping up a frenzy for profit. Why don't we lockdown our highways when there are 600,000 deaths from auto accidents? Why not lockdown breweries when there are 2 million drunk-driving incidents? Why isn't there a frenzy over influenza?

Covid frenzy has a better marketing campaign. It's the kind of thing that has people claiming we are "engulfed by flames" when things get smoky.
> The infosec community likes to latch on to any little vulnerability it can and act like the sky is falling

That's because while a given potential exploit might not be a huge deal, a collection of exploits become greater than the sum of their parts, so if you're security-minded, then you want as few of those parts as possible.
You can't have "really expensive" and "crap quality" without going out of business.

It's a pity they don't sell the electronic bits (preloaded with the firmware). I can probably fashion quite a nice trackball enclosure from a block of wood; probably much nicer than 3D printed cheap-feeling plastic.
not even kidding going to dump all my visa stock. was heavily invested in it too. sad
Isn't it easier and safer to vaccinate the teachers? There are less of them and they are of the age where the current vaccines are considered safe.
It's in quotes, I don't think it's their point.
Do people not understand quotation marks?
> It's not like a visit to the dentist either, it's a major surgery.

My father had a pacemaker, and for long enough to receive a battery swap. The battery for that particular model was implanted under his shoulder blade; the swap-out was performed under local anaesthetic.

The original implantation was a bit more complex from a surgical perspective, requiring keyhole surgery and an angioplasty to run the wire around his heart as well as to implant the battery and controller. But the point is: these devices can be installed and expected to perform for decades, so the engineering design is of necessity highly conservative and has long-term maintenance in mind. It's also safety-critical: if the device malfunctions, people can die.

PS: a pacemaker is not an implanted defibrillator. (Also, my father died in 2017, so what I'm describing is probably a decade or two behind the state of the art.)
> Get more automation, and then you have the current state of affairs - no nuance, no clarity and the unfeeling boot of an automaton on your account.

You seem to be taking as given that they have to be making these decisions to boot people off. You can have all of the inexpensive automation and little customer support costs you want and it works just fine, as long as you don't try to enforce a Kafkaesque set of terms and conditions to begin with.
"Even if true, so what? It's their bodies. They should be allowed to choose, just like you are."

Is this still true if unvaccinated takes a hospital bed away from someone else or increases insurance costs to everyone else due to more expensive care?
From https://www.nytimes.com/2021/08/23/us/politics/fda-approval-...

> Some experts have estimated that full approval might convince just five percent of those who are unvaccinated to get shots.
I actually think your analogy of self-driving cars is a good one. If a billion people had safely rode in self-driving cars in the last year, and it saved hundreds of thousands of lives, I think we'd be approving them too.
This odd but strangely entertaining site looks at the maths of the crop-circles - http://www.hypermaths.org/cropcircles/
Arguably, but they were reportedly getting ready to give the order either way.
The opposition to rushed or mandated COVID vaccination has close to zero ties to the “anti-vaccine” movement. Unless you watch CNN and MSNBC as your primary source of news, of course.
This is exactly it. Governments have no problem interfering deeply in the private sector when it comes to enforcing the public policy. We need that for the internet.

Even worse, when it comes to real estate, the government has no problem interfering in the livelihoods of landlords (often small operations), but completely absconds its responsibility on the internet dealing with giant billion-dollar corporations.
This is also about what’s coming out of their bodies and going into others’.
That’s not really what your link says tho.

> Both vaccines were highly effective during this study period against SARS-CoV-2 infection (mRNA-1273: 86%, 95%CI: 81-90.6%; BNT162b2: 76%, 95%CI: 69-81%) and COVID-19 associated hospitalization (mRNA-1273: 91.6%, 95% CI: 81-97%; BNT162b2: 85%, 95% CI: 73-93%). However, in July, the effectiveness against infection was considerably lower for mRNA-1273 (76%, 95% CI: 58-87%) with an even more pronounced reduction in effectiveness for BNT162b2 (42%, 95% CI: 13-62%). Notably, the Delta variant prevalence in Minnesota increased from 0.7% in May to over 70% in July whereas the Alpha variant prevalence decreased from 85% to 13% over the same time period.
Please see my other reply. Vaccinated people have a significantly reduced risk of death, so there is virtually no risk from being exposed to those without a vaccination.

>The same people that don't understand vaccines are also likely to think masks don't work

I don't see how this is relevant. It just seems like a strawman argument to dismiss people who might have legitimate reasons for not having the vaccine or otherwise just want to exercise their right not to have it.
Any physician may prescribe any FDA-approved medication outside the scope of the label if it's indicated in their medical judgment.

That means that it may be prescribed to individuals <18 in some circumstances, and that it's legal to do so (explicit emergency authorization notwithstanding).
"Ingredients" are a boogeyman now?
50 Days of Learning: One Week as an Engineer (2019)
Net implies you are counting positives and subtracting negatives. As in, net lives saved vs. lives lost. Subtracting the 341 people who got breakthrough and died of irrelevant reasons does not make this a "net" metric.

You're right I must have missed the "/" symbol. But the point remains that your comparison is irrelevant and ignoring very bright signals that the vaccines are effective. The rise in percentages are not as noteworthy as you imply as we're dealing with very small numbers to begin with.
Did they ever make their data available?
I've gone to a variety of stores in a major city, and never been asked for my vaccination status.
Doctors washing their hands saves way more lives than masks do, and hand washing doesn't have negative side effects like masks do (e.g., constantly fogging up glasses, and keeping people who are hard of hearing from reading lips).
Absolutely, a good way to approach this. I like to use the Tarot Cards of Tech[1] to inspect complex products.

[1]: http://tarotcardsoftech.artefactgroup.com/