skysight-inc/HackerNews huggingface dataset:
Yes this is a great point. The primary concerns & warnings are generally around vaccine induced immune escape, which is a realistic consequence of indiscriminate compulsory mass vaccination [1][2][3][4][5][6].

That said, there is general consensus in the literature that the vaccines are mostly safe for adults in the short term. However for certain sub-populations (eg pediatrics and pregnant women) there isn't enough evidence yet from clinical trials and longitudinal studies to conclude with certainty that the benefits of compulsory mass vaccination outweigh the risks.

[1] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
https://pubmed.ncbi.nlm.nih.gov/33909660/

[2] Can we predict the limits of SARS-CoV-2 variants and their phenotypic consequences?
https://www.gov.uk/government/publications/long-term-evoluti...

[3] Why does drug resistance readily evolve but vaccine resistance does not?
https://royalsocietypublishing.org/doi/pdf/10.1098/rspb.2016...

[4] The adaptive evolution of virulence: a review of theoretical predictions and empirical tests
https://pubmed.ncbi.nlm.nih.gov/26302775/

[5] Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens
https://journals.plos.org/plosbiology/article?id=10.1371%2Fj...

[6] Necessity of COVID-19 vaccination in previously infected individuals
https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...
So the people opposed to vaccination are helping science by being the control group?
Sometimes k8s, docker, and/or microservices are the right choice. Sometimes CI/CD is necessary and sometimes it's overkill. I think your best path forward is to learn some of the new hot technologies and recognize when they are valuable. If someone else forces you to overengineer or overcomplicate, the best you can do is advocate for something better and then be the guy who can do it anyway.
Pay per click license or subscription with a base set of clicks per month with a lower per click price.
We also sell keyboards with the same golden customer service.

Platinum level sold separately.
While I agree, law enforcement in the U.S. is supposedly bound by the "expectation of privacy" where, I think we can all agree, we ought to have an expectation of privacy when we send an email directly to one of our contacts.

Of course Google and Gmail (as an obvious example) are not law enforcement so they can specify the terms of privacy when you sign up, scan your email if they wish, etc.
Our visible universe has event horizon around it, which has thousands of galaxies falling away from it and becoming unobservable every day, due to cosmological redshift.

For some reason, physicists are not concerned with information loss via this one. I would be glad if somebody explained the difference.
> In fact, crime rates among poor whites are virtually indistinguishable from those among poor blacks.

This is untrue. From my prior research, virtually every analysis concludes the opposite - that income alone cannot explain the difference in crime rate between black and white Americans. Most studies show income as 30-60% of that regression, which is huge, but when comparing similar income brackets, African Americans have a higher crime rate than whites in almost all of them under $100k. To cover the full difference, it's necessary to bring in other factors (in particular, the rate of single parent households). Please cite a source for the claim you have made or retract it.
You can cite 100 counterexamples when using this simplistic kind of reasoning. Covid numbers are quite high in South Korea and Japan which both have sky-high mask compliance, for example.
I have had such a blast playing with this for the last week, reminds me a lot of what you are able to do with noteblocks in Minecraft.

Here’s my newest creation
https://go.ludotune.com/hui4
You're going to get some number of people against anything. 96% of doctors were fully vaccinated by June [1], for example. Does the 4% holdout actually worry anyone? It shouldn't.

You also have to double check beyond headlines. For example, I saw people talking about how the FDA EUA panel wasn't a consensus for Pfizer 16+ back in the day. Turns out, most of the people who were hesitant just wanted to start with 18+, not 16+. That's a huge difference from what some of the headlines were saying.

[1] https://www.ama-assn.org/press-center/press-releases/ama-sur...
One gdb trick I used:

Use simple gdb script, break, print vals, cont,
This allows one to debug and app's internal states without rebuilding with printf enable.
Combine the above with automated regression test system, one to debug very hard problems that might take hours/days to repro.
It's only a matter of time before this freemium VPN gets kicked offline for all the illegal activity it will facilitate for free.

Hacking, CSAM, Piracy, etc. will all be routed through Cloudflare's massive network -- and all for free.

And, I don't think they keep serious logs on traffic. So, DMCA holders are going to throw a fit if this gets popular, which seems to be the aim?
But you're forgetting that currently these vaccines are not really doing a great job at decreasing hospitalizations in at-risk populations. Look at Israel. Thanks.
> Enter our own WireGuard implementation called BoringTun.

In retrospect, I guess it's obvious that when nerdy but extremely popular tech mogul globally popularizes a pun on tunneling and boring that we'd see it pop up other places.

Still though, ugh.
>In short: your scenario works only when everyone does their job poorly.
Yes well thats vaguely the shape of the point I was making
Last time I saw a number, vaccinations offer more than ~60% protection against infection with Delta altogether - did you run the numbers / see some study to arrive at "they're spreading it to more people", or is this a case of "it aligns with what I already thought / it justifies my current behavior so it must be true"?
Agreed that it's bad for science and for society when we start ascribing moral orientation to the two sides of a question of scientific truth. These days people seem to do it often on the question of efficacy of preventive measures against COVID, also climate change, and biological correlates of intelligence.
This really, really is not true.

Many drug and vaccine approvals in the past have been done before the trial has run its full course. Many drug and vaccine trials have given the placebo group the real drug once safety and efficacy is clear - before the end of the trial.

This is not new, and frankly I’m a little surprised to see such conspiracy theories on HN.
When I take a nap and set the alarm on my phone to vibrate only instead of ringing, I place the phone on my chest so that it wakes me up. Because of this post on HN, if I ever get an ICD, I now know better. I wonder how many people don't know.
What changed? The Delta variant arose and started spreading more effectively.

This is why getting spread under control is so important: each time the virus replicates there’s a chance of a new advantageous mutation making the problem harder. Wearing masks and vaccination are how we break that cycle.
I used to walk in a park every night at around midnight, in a big city with tons of police gang units. Not once was I ever approached by anyone. It was peaceful every time, without exception.

That changed when the police started driving their massive SUVs on the park path after 11pm to make sure nobody was in the park. The first time they did it, they argued that the park was closed, though there were no signs saying the park was closed. It turned into a big verbal argument but thankfully it didn't escalate badly. That night I looked up the city code and found that if there's no gate, then the law allows me to walk to the end of the park. I went to the police station to complain, and was told that I shouldn't worry about it because they're not trying to get "people like me".

But still, it happened again, and the cop basically told me "we're going to keep doing this until you stop". So, while the cop wasn't exactly disrespectful, he was wrong about the law in a way that manifested no differently from persistent harassment. They're just trolling for anything illegal on a default position of wronghood.

You're asking the wrong questions.
> going on a ventilator, and begging

You read about it, I have heard from the witnesses. Some beg, some show fatalist. In fact,

> until they’re bitten

some do not quite realize that it is death involving slow asphyxia we are talking about... Days of drowning, not minutes.

> Risk assessment [...] is made worse by conflicting opinions and studies, and not being able to discern truth from fiction/sensationalism

Which is one of the biggest mess behind e.g. vaccine hesitancy, not to mention not convincing narratives about correct behaviour to prevent spreading.

Anyway, the communicational mess is a disaster, while this reference "fiction" is more problematic. It is not, at this level, something you discriminate easily. When Derek Lowe writes some find him credible, when Robert Malone speaks some find him credible - keys for discrimination are not easily at hand.
I think the main non-conspiracy reasons fall into these categories:

- Fear, hesitancy about potential long term risks.

- Resistance to government mandating a vaccine (freedom, low trust in government, other options not being considered)

- Resistance to the cultural paradigm of "un-vaccinated = bad/deplorable person"

- Belief that the risk of COVID is already low (at least for them)
5ms Global Redis Latency with Edge Caching
Old Europe (Archaeology)
Indeed, there are plenty of people who "believe in science" and trust authority figures, who believe in various forms of woo.

We can do better than guilt by association. It's a very weak argument, and turns more people away from potential vaccination. In fact insulting the remaining audience is worse than preaching to the choir, because it even turns away people who were previously 100% on one's side.
variations in the virus are predictable, but which ones really catch on and how are hard to predict.

I don't know how phizer/moderna/etc balance needs to develop different drugs against all possible variants but I expect that once a strong variant emerges they are well incentivized (financially and culturally) to scale up development against it.

The real surprise is how slowly our social and political institutions respond, not our pharma institutions.
Fair question.

It looks like flu (influenza) hospitalizations run at about 0.15% of total population, per year.

SARS-CoV-2, at 1-5%? Although that might be vs confirmed cases (?), which would muddle the numbers.

But suffice to say substantially higher. So I think there's an argument to be made for this being a COVID only measure (and probably measles, etc too).

IMHO, people are entitled to freedom regarding their choice to vaccinate.

But if they choose to exercise their freedom in ways that limit my freedom (via resulting lockdowns, mandatory masking, banned social gatherings, preventing businesses from operating normally, etc.), then that doesn't feel very fair.

They're externalizing the consequences of their decisions onto me, and the rest of society.

So yeah, IMHO, their decisions: their bill to pay. With their life, if necessary.

(But I may be biased, as I have family working ICU, triaging unvaccinated coronavirus deniers who show up at the ER, begging to be saved, who are then sapping care from non-COVID patients...)
The goalposts would not have moved if people actually put the health of their communities over their personal desires and convenience.

Other models are certainly possible, but only work in places where people have higher trust in their government, and think about collective welfare over their own individual selfishness. Unfortunately, people in the US (and much of the West) care too much about "mah lib-ur-tee" than doing their part to help keep their neighbors healthy.

Also I think your focus on Japan is a little weird; they went through their own bad time with COVID, and even consider the recent case of the large flare-ups surrounding the Olympics.
I don't need a person with a doctorate degree to treat me. I just need a person who has a reasonable understanding of how does a human body work and a reasonable skill of doing particular medical procedures.
I agree with the OP that trustworthyness is a key requirement for building a successful co-founder relationship.

What I can't work out is how you would measure trustworthyness or (perhaps more importantly) how you would establish if you are good at measuring trustworthyness.
I don't see the link between these articles and the control groups receiving the vaccine after 14 days? It seems here that Pfizer gave permission for participants to get vaccinated on March 1st, which is 8 months after the start of phase 3 trials.

Imagine you volunteered for a very experimental trial for the greater good and then were told that you were given a placebo and now cannot receive a vaccine for several years and will have to be more cautious. You can see in the article that a volunteer from the trial is strongly advocating for giving the participants access to vaccines.

Obviously this complicates the statistical analysis (you can try to use a double-blind crossover study to get some statistical power out of this, but clearly the messaging gets more complicated), but I'm not seeing anything about a "14 day" timeline.

It's also worth noting that any study participant can just freely choose to break the study and go in and get vaccinated (lowering the measured efficacy of the vaccine)_whenever they want. Giving them a concrete date is a good alternative to that.
Serious breakthrough cases remain rare, delta has not changed this
A bicycle will get me to places even when I don't have the battery, or don't have a place or the time to charge it. Now are you going to go down the rabbit hole of arguing about definitions?
I'm just happy HN is such a fringe community not representative of the general population. It's pretty sad when you reach a point where you make medical decisions to "own" the "other team".
My personal experience is this: I love building stuff. I love the web. For a long time I loved React/Vue but over time I began to worry about desktop, mobile, PWA, future-proofing and found myself way over-thinking MVP and proof-of-concepts stacks. I tried and tried to limit my scope but found it was really hard to have discipline. Should it be CRA or Next.js? They are both awesome so I can't really decide. Should I use react-native-web so that I can put out mobile apps? How important is being in the app store? Etc, etc, etc.

One weekend not too long ago, I started a Rails app with Hotwire and found myself wonderfully, nostalgically productive again. Maybe I'm old, maybe I'm burnt out but I can tell you one thing: I'm having fun and building neat, performant, and fast web apps. I hope that speaks for itself when I look for my next job.
because people are so polarized the idea of engaging corporations to intrude on your private messages is ok if its your 'team'.

People never seem to realize what they're setting up are mechanisms and agreements that will facilitate further interventions. The mechanisms will be used against everyone, forever. This is just further increasing the centralization of power behind politicians who never deserve it and who use it on people with no power to resist, no matter whose team they're on.

or they realize and are so pre-occupied with their team they don't care, which is sad and short sighted.
Thanks for the list too. Looking at the examples from the 90s on - aside from the rotavirus vaccine - this looks like a list of examples for why there should not be concern. Concerns were raised for vaccines and subsequently found to be uncorrelated.

Regardless of interpretation too, this doesn't support the claim the commenter made - there has never been a vaccine recalled within a year.
Google Advanced Protection Issues?
Hey, you guys probably already use Google Advanced Protection for your accounts, so I'd like to know if you are experiencing issues with login codes on https://g.co/sc - here, no matter how many times I try to renew the code, it stays invalid, and has for months now.
Haven't been able to get in touch with anyone @ Google about it.
> once the vaccine is available to all age groups, the only people that need to be scared of it are the unvaccinated

The age groups to whom the vaccine is not yet available have no reason to fear Covid in 2021 any more than they did influenza in 2019.
The UK has had an industrial intervention policy for ages. Its undeclared but it basically involves supporting finance, real estate, business services and insurance in London above all other stakeholders in the country.
I agree in general. The difference here is that the quote about longterm effects being unknown is from the FDA. A layperson could set their standard as being when the FDA has that information. Hopefully the FDA has objective procedures and measure to make those determinations. I feel that would be a reasonable approach.
> Yeah, what does the vaccine do that the virus doesn't? There's a lot the latter does that the former doesn't. That's the part I don't get.

Well the main feature of the vaccine over the actual virus is that the vaccine doesn't give you covid. The vaccine doesn't cover all of the multitude of compounds your body might recognize on the virus, but it covers enough for most people to build a better immune response to the actual virus than nothing. There is the issue that the viral strains are mutating and so over time so that a recently-vaccinated person today will probably do worse than a recently-vaccinated person 6 months ago, but there's not really much you can do about that.
The NPR citation you posted suggests the Moderna control group was offered the vaccine in January 2021, about 14 days after it was approved.

Moderna was approved on December 18, 2020.[0]

Moderna phase 3 trial started on July 27, 2020.[1]

IE, the control group was offered the vaccine more than five months after the trial began. This is before completion of the trial (Oct 2022 for Moderna, IIRC), which is an issue, but this "14 day" as written seems to be suggesting that it was 14 days after the trial began, when it's actually five month.

Additionally, when a treatment proves to be highly effective, it's normal and appropriate to start providing that treatment to the control group early, because leaving them to die or otherwise suffer an illness is considered unethical. This isn't something unique to the COVID vaccines.

[0] https://www.fda.gov/coronavirus-disease-2019-covid-19/modern...

[1] https://www.cidrap.umn.edu/news-perspective/2020/07/phase-3-...
A virus doesn't become more contagious and deadly. It can only do one or the other. Think good, fast, cheap in programing terms. Pick 2.
> people will pivot from “it’s experimental” to “it was rushed due to politics/greed”.

What is it, day 600 something of "just two weeks" to stop the spread? Oh wait, that's just the _other side's_ fault for not following the rules as well as you did.

From where I sit, it seems like a lot of people are having a hard time admitting that shutting down the world's economy may have been the wrong choice, hindsight.
I feel like we should separate professionalism (i.e. the spectrum of familiarity to over-familiarity) from empathy.

To me, how I want to see empathy applied in a military context, is nothing to do with familiarity or chumminess, and everything to do with the idea that, if you are my commander and you order me to battle, to fight and to die, that you do so carrying the full weight of that responsibility, that you understand my life and my worth as a human being, and that you empathize with the gravity and danger of what you are asking me to undertake, and that you won't spend my life in vain.

That is the real root of empathy, in the military, for leaders to really truly understand the both mundane and yet impossible weight of what they are asking their soliders to do. If you cannot empathize with the human condition at that level, then you should not be fit for military leadership (naive of me, I know).
It always makes me excited to see what people are doing with the trust-dns libraries. Thanks for your contributions to the project. It's very cool to see some performance testing tools like this coming to Rust.
My guess is that people who can't code can't pass, but people who can code might pass. It's a kind of extreme fear of false positive. Then the firm that does the testing needs to look like they're doing something beyond fizzbuzz and you end up with crazy tests.

It never made sense to me, I always just do a technical conversation and if for some reason a muggle has gotten an offer it's easy to detect and deal with. People don't last long in coding jobs if they can't do it anyway.
tens of thousands of people in the USA die every year from influenza. This does not cause most of us to be "scared" of influenza. Why not? Because (1) the individual risk is vanishing low except for a relatively small high risk demographic (2) the public health aspects (i.e. overloaded health care systems) are generally easy to control because it is not extremely infectious.

(1) is and always has been true for COVID, but (2) remains unresolved at this point.
As my original quote shows, it is not that simple. "Harm" is a very nebulous term. The sterilization I mentioned above was harm to the body politic, namely the drain on the economy and society by the support of people who would never be productive. That was the reasoning.

You have to be more specific than mere "harm," which is the point of why I posted that. You need boundaries, clear ones, pre-defined and inviolable, else you are setting yourself up for the scenario which has already happened once in history.
https://developer.mozilla.org/en-US/docs/Web/CSS/@media/pref...

Doesn’t look like a debug only feature to me
No, by lockdown I mean not allowed to go out unless for emergencies and no venues/theatres/restaurant open (except takeaways).
Standard default usually means light. Changing this to dark means forcing new default. Since there is a browser limitation in telling exactly what a user wants—dark UI and light content or dark UI and dark content—forcing a new default considering that it's exactly what a user wants just based oninformation about UI despite the fact that there are not enough signals is a bit wrong. The safer bet would be to provide a choice but keep defaults to general (light) and not make choice for a user just judging by UI theme.
Deno feels like past the peak technology to me. You've got years and years of labor put into the Node.js ecosystem, and then the guy comes out with something that totally drops all of that for some gimmick features.

Could you not just build a URL loader and cache for importing in Node.js? Could sandboxing not just be a flag in Node.js? Do you really need TypeScript built in?

I'm not going to throw years of my and other's work away for some gimmicks. It's just a bad investment.
That argument makes sense only if the borders were shut down though -- right ?

I'm pro vaccine, but even if everyone in the US got vaccinated in the next month we would still have to worry about vaccine-resistant variants coming in via other places.
You might be underestimating just how deeply children sleep.

My kid gets her diaper changed several times a night and sleeps through it. If she does wake up she cries for a drink of water then immediately goes back to sleep.
Meanwhile hitting Ctrl-A in any text field doesn't do anything. Single quotes don't work in formulas and the list goes on...
>I'm already triple vaxxed (booster),

May I ask why? I've had two shots without much hesitation but this whole booster thing came out of nowhere and gives me "fool me twice" vibes. I understand getting a flu shot every year to target new strains but this would be the exact same shot as 8 months ago.