skysight-inc/HackerNews huggingface dataset:
Hypertumors aren't really a good explanation for Peto's Paradox. Yes, larger animals would need larger tumors to kill them, and larger tumors are more likely to develop hypertumors, but even if cancer didn't kill a large animal we'd still expect to see all those "small" tumors that haven't yet developed hypertumors.

Further, Peto's paradox doesn't just apply to large organisms: small creatures get higher cancer rates. You'd expect there to be some threshold below which the odds of a hypertumor developing are incredibly low, and all organisms that can be killed by tumors smaller than this threshold would have a cancer incidence rate proportional to body mass. At the same time there should be some threshold where a hypertumor is basically guaranteed, above which cancer deaths would simply stop regardless of body mass. Instead, cancer rate is independent of body mass across the spectrum.

Then, the lack of correlation between cancer rates and body mass only applies between species. Within a single species, animals with more body mass do have higher rates of cancer and vice versa. This is directly contradictory to what we'd expect if cancer suppression was a result of increased body mass.

Finally, closely related to Peto's Paradox is the fact that longer lived species have lower per-cell division cancer rates than shorter lived species. Animals with different lifespans but of the same bodymass can be killed by tumors of the same size, so you need some explanation other than hypertumors (which occur as a function of the size of the tumor) to explain this observation.

Evolutionary adaptations that limit cancer are both a simpler and better explanation for these observations. Every animal is going to have some threshold in its life by which it is likely to have passed on its genes, and another threshold beyond which it is unlikely to better pass down its genes. Any gene that kills you before the first threshold is going to be strongly selected against, any gene that keeps you alive after the second threshold isn't going to have much selective pressure supporting it. A mouse in the wild can successfully pass on its genes in 3 months and is unlikely to live past 18 months due to injury and predation. While mice under ideal conditions in captivity have lived for up to 6 years, a gene that helps mice suppress cancer when they're 5 years old isn't doing wild mice any favors. On the other end of the spectrum, blue whales take a minimum of 16 years to reach genetic breakeven, and realistically given their distribution it could easily take much longer. A mutation that causes a 5 year old whale to get fatal cancer will never get passed on to offspring. We should logically expect that any species will continue to evolve cancer defense mechanisms up until the point at which cancer is no longer the limiting factor for passing on their genes, at which point evolution stops selecting for further improvements.
https://archive.is/rGAbz
> They will easily raise more money via debt or equity financing. There is no way they just collapse into bankruptcy.

> This article seems to dismiss how deep and liquid capital markets are today and easy it is to raise capital with even a sniff of cash flow..

I find it hard to share your optimisim in how easy it will be for them to raise more money. Regardless, my thought experiment was _if_ they go bankrupt, what happens then...
It's explained right in the linked Wikipedia page:

> The term "memoization" was coined by Donald Michie in 1968[3] and is derived from the Latin word "memorandum" ("to be remembered"), usually truncated as "memo" in American English, and thus carries the meaning of "turning [the results of] a function into something to be remembered". While "memoization" might be confused with "memorization" (because they are etymological cognates), "memoization" has a specialized meaning in computing.
Don't forget to give part of the blame for the forest woes on worms:
https://www.canr.msu.edu/news/the_dirt_about_earthworms
I couldn't help thinking of this:

https://www.npr.org/sections/money/2013/12/11/250200378/we-f...
You can say this for trends, but not for individual cases. Roughly half the human population are women.
That's good to hear. I hope they keep going down that path. To refer to another game, in any of the Soulsborne games (Dark Souls, Bloodborne, ...) by From Software, as you level up you get to contribute points towards stats which affects your ability to wield weapons and how much damage they do. You don't even have to equip them, the game gives you a diff of what your new damage will be along various dimensions (physical, magic, etc) as well as how your "equip load" is affected just by inspecting it. Although this doesn't necessarily mean you can understand the difference between a really heavy, highly damaging weapon vs a fast weapon, by reading a wiki or by playing through once or twice you'll have a very good base understanding of what different weapons bring to the table and how your character drives those strengths/weaknesses.

With DCSS? Well... how much damage you do is going to depend on whether or not you're wearing a shield (what size?), what kind of armor you're wearing if any, how much you've trained for that weapon class, how much STR you have, what bonuses it has, and what bonuses you have from gear. Then RNG will play a significant role on top of that. Maybe RNG applies twice, once for your swing, once for their defense? It's been too long, I can't say confidently.

I realize it's challenging for the interface design because everything is already tight but I'm sure there's a solution. If I equip this armor/weapon/jewelry, how fast will I be attacking compared to now? What will my damage distribution look like before enemy resistances? Same with allocating stats, please give feedback in the form of derived data that is closer to the thing I care about (surviving).
This happens in software too.

Over the last 4 years our team has achieved a lot: huge numbers of valuable changes and improvements to our platform. But it's been much harder than it might otherwise have been because we've had to make those changes with the systems in use. Had we started from scratch, or been able to take downtime, there are a lot of projects we could have done much more quickly, but we had to keep the business running - it is, after all, what was and is paying all of our salaries.
The human study was literally done because denial of chronic lyme persisted despite multiple reliable studies in animal models.

It's quite disgusting and begets further questions as to why such attitudes towards Lyme exist in the first place.
"muchless a Texas based one"

What's with the Texaphobia?
Isn't that another Dr. Falsie vaccine?
"In the Carboniferous Epoch we were promised abundance for all,

By robbing selected Peter to pay for collective Paul;

But, though we had plenty of money, there was nothing our money could buy,

And the Gods of the Copybook Headings said: 'If you don't work you die.'"

--Rudyard Kipling
I'd be curious to know if it is helpful or hurtful for me (as someone who can afford to buy "new" cloths) to shop at secondhand clothing stores.

Am I preventing clothes from getting shipped out to Africa, or preventing someone of less means from finding something to wear? Or a bit of both?
You are being willingly ignorant if you believe that. Look at the title of the article.
The “boosters expected to be “allowed” real soon now(tm)” hype is getting to be a bit hilarious at this point. People have to start wondering “why September, why not now?”

That’s not a question we really want people to start asking. Nor, “why is there no FDA Commissioner in place to do the “allowing”?”

To quote the featured article, “Senior Biden administration health and medical officials have been discussing the possibility of calling for booster shots for weeks and are nearing agreement on the issue, said the people, who added that a final decision hasn’t been made.”

What could they have been discussing “for weeks” now and still not “come to a decision”?

I’ve been hearing Fauci say “vaccines as early as September” for weeks now. I guess if you say it enough it becomes true? Like Peter Pan.
My experience with desktop hardware is that traditional BIOS boots faster than EFI, because the former does much less as well. (This is not the difference between "BIOS boot" and "EFI boot" options in an EFI BIOS, but rather a "pure native" BIOS vs "pure native" EFI with the same motherboard.)
I love your content, really inspirational! What are your favorite resources for learning about the variety of topics you've tackled, from drivers, to cryptography, to compilers?
That's right. It only read from the pink ones.
AIDS can already be treated in a way that doesn't shorten lifespans significantly.
Oh so the machine isn't sending a hash of the binary on exec? Tell me what I got wrong.
How to help Afghanistan: Things you can do for a country in crisis
I think that you will find that for subnormal numbers any math library will use the identity function for sin(x) and 1 for cos(x)
> imagine what some (human) intelligent design can achieve

We don't have to imagine. Everyone here is familiar with Clippy.

More seriously, I think this is a category error, rather than just hubris. I don't think human intelligence is a substitute for evolutionary grinding.
I wonder how does it compare with Microsoft’s implementation, there: https://github.com/microsoft/DirectXMath/blob/jan2021/Inc/Di...

Based on the code your version is probably much faster. It would be interesting to compare precision still, MS uses 17-degree polynomial there.
Agreed, and according to this data: https://www.statista.com/chart/20822/way-of-meeting-partner-... it's now the most common way of meeting a partner.
> hard to believe it got past the editors and into publish.

Whether it is blocking Amazon HQ2, or the disastrous handling of the pandemic (If NY was its own country it would have had one of the highest per capita nCov2-mortality-rates of all industrialized nations), or the deteriorating security situation – decades of one-party rule leave behind a dysfunctional, rotten, place.

All of those failures where known to happen in the moment the root-cause policies were enacted. Dysfunctional places enact them inspite reality's warnings, because by now reality is a white supremacist.

The subway-cars can become a place to forni- and deficate for the homeless for weeks, making it unusable for citizens. But critique cannot make a dent, becaue it is guilty by association.

That's why even if tax-payers flee the place day by day, its institutions must defy that reality. Insitutions like the NYT are a major part of the city's dysfunction. They are to blame, thus you see such rediculous articles getting "past the editors".
I started https://ipinfo.io as a side project, and eventually transitioned to working on it fulltime by myself for a while. I really enjoyed that time, but as things progressed it was a huge relief to bring in other people to help. Offloading support to people that were better suited to dealing with customer issues, and enjoyed doing that more than me. Then offloading design work to someone who can actually do a good job of design. Then getting help optimizing some DB queries. And before you know it we're a team of 17 globally :) I sometimes fondly remember the times that it was just me working in a coffee shop by myself, they were certainly simpler times. But the business would never have been able to get to the stage its at if I was doing this by myself.
Until the late 19th century, paper was more frequently made from rags than wood pulp. The switch to wood pulp was because paper demand outstripped rag supply. Perhaps it's time for a return to increased rag content in paper.
Curious how much of that rate is because of AirBnB's and VRBOs closing out with no travelers and these units hitting the market vs people moving away...
I was bit by one of those about ten years ago, but no unusual effects thankfully.
Re-using glass containers is actually an extremely low chance of contamination. We have had easy glass sterilization techniques for a long time (most dishwashers have a sanitization cycle). Further, your shelf life won’t be significantly reduced, unless you just don’t clean your containers.

The underlying argument you were responding to wasn’t really greenhouse gas focused. The discussion was mostly about plastic waste in the oceans and our environment. While it is possible the greenhouse gas budget is better with plastic, this doesn’t address the problem of accumulating forever waste within our environment.
CORDIC was great for devices that were too simple to include hardware multipliers.

CORDIC, in its basic form, produces just 1 bit of result per clock cycle. Only for very low precisions (i.e. with few bits for each result) you would have the chance to overlap enough parallel atan2 computations to achieve a throughput comparable to what you can do with polynomial approximations on modern CPUs, with pipelined multipliers.

CORDIC remains useful only for ASIC/FPGA implementations, in the cases when the area and the power consumption are much more important than the speed.
You'd think so, but somehow it hasn't happened. I'm just waiting for PCSX2 to mature a bit more on Xbox, then I'll be playing PS2 games on my Xbox too.
What are we supposed to do? Corporations own the government and the people who can afford guns support it.
and ticks in Germany are massive compared to the ones we get in North America.
Tips to Achieve a Superb Podcast Studio Design
Can you share what you tried to build/sell and failed?
Solopreneur here.. it ain't easy, the ride is a rush though and I wouldn't trade it for a full-time job.
> If you are following some common flow and it turns out you're not happy doing that

You assume people are actually capable of being happy. I find it highly questionable.
There's a lot of major interests out there that have essentially been at war with Uber from day 1. The cab driver's unions in different cities primarily. All of these interests want nothing more than to see Uber fail and will amplify any projections like these.

My simple question...if Yellow Cab can be profitable, what makes it so hard for Uber or Lyft to be profitable?
Congrats on the new launch! Scrimba, which could not exist without Imba, is one of those insane magical web things that is criminally under-appreciated. I hope Imba takes off!
This is a very common assumption in Physics, e.g. https://en.wikipedia.org/wiki/Pendulum_(mathematics)#Small-a...

Whether it's appropriate in a numerical calculation obviously depends on the possible inputs and the acceptable error bars :)
Show HN: Viddy – Modern watch command. Time machine and pager etc.
Doctor: I've got good news and bad news. The good news is we have genetically modified you so that you will never get cancer.

Patient: What's the bad news?

Doctor: In about 8 months you'll be able to unzip your pants with your nose.

:-)
https://archive.ph/mT6Ip
I have a little bit of history suggesting alternative COIN strategies to top brass. It’s been 60 years now. Maybe time to rethink.
Yes but we can still increase quality of life (not taking pills everyday) and global accessibility with developing a vaccine.
Not necessarily, you could "cache" them in a compilation step and then use the table at runtime.
In New York City there is currently a project ongoing deep underneath Grand Central Terminal to add an entirely new 8-track, 350,000sqft station connecting Grand Central to the Long Island Railroad.

Similarly, all materials for that project enter and exit from the other end of the project tunnel in Queens. New York City at ground level has no indication that the work is ongoing 140 feet below their… well, feet. Very neat!
That is precisely the technique discussed in the article: it's the first term of the Taylor expansion. Except that the article used more terms of the expansion, and also used very slightly "wrong" coefficients to improve the overall accuracy within the small region.
Pray that the side effects are well-studied before the CDC decides to administer it to every infant within minutes of birth (like they did with Hep B, another sexually-transmitted disease to which most people will never even be exposed.)
Of course not that's my point - 'if' millions of Americans die, it's not really comforting to say 'oh we'll make it through'. Of course we'll make it through, that's not the issue.
I learned about it reading the quake 2 sourcecode. In school or tutorial articles, they always teach the first technique, I find. "Delta timing" is what I knew it as.
In (Southern) Africa, HIV/AIDS is considered more manageable than Type II diabetes.
I find it fascinating that the gig economy makes sense. Business 101 is to find economies of scale. In the taxi business, cars are purchased in blocks, maintenance is centralized (and easy since the cars are all the same), gas prices are negotiated, insurance is negotiated. The gig economy pushes all those costs to the driver, who has to buy market rate gas, pay a high market rate for individual insurance, pay Joe the Scammer for repairs...
I think the “on the ground” answer varies depending on you, where you are and what insects are around. 70% of deer tick bites may carry Lyme, but the percentage of insect bites with red rings that are Lyme is probably different. If you’re walking through northeast pine forest or low density suburban woods, assume Lyme!

Red rings from bites are not uncommon in general. I know I get a reaction from horse flies that looks to professionals like a potential deer tick bite with Lyme.
I am pretty they do, while I haven't seen them in my yard, they love my neighbor's ~1acre lawn abutting woods across the street. I see them hanging out there all hours of the day.

I actually just learned about guinea fowl elsewhere in this thread! Definitely will be looking into it.

I also started doing the permethrin soaked cotton balls in tubes. Mice collect the cotton for their nest and it kills ticks. Also our dog gets tick-killing meds and takes out a non-trivial amount just by collecting and killing them.
At most stores each individual piece of produce has a scannable sticker on it.
Ask HN: Does software equal software build/image?
<rant>

So there is a C++ application to be tested via a component test and there is a 'test-flag' passed to the test executable to indicate that it shall be executed in 'test-mode'.

That is because some external dependencies aren't available and shall be left out or simulated in the test run.

I was arguing with a colleague, that we are effectively testing a different software by doing so.

My colleague on the other hand stuck to the point, that it's still the same software being tested, because in his mind software equals software build. For changing the build flags would result in 'different software'.

I was trying to convince him, that software is a more abstract term than its manifestation in an exectuable file, and that by his definition there could be two branches within the executable doing completely different things based on the 'test-flag'.

Actually I'm still triggered by his stupidly narrowminded definition of software.

</rant>
I remember RX 580s going for 170 Euros before the pandemic. I can only hope that prices reach sane levels sooner than later, but I suspect we're going to see at least another year of outlandish prices.
Why wouldn't you at least include the x^3 term in the Taylor series for abs(x) < 0.1?
As someone feeling a bit rough after my first Pfizer dose and generally is a hypochondriac - nooooo
> Generally, the deer are only overpopulating (at least to the extent you describe) in areas that aren't hunted

Central Massachusetts has a very active deer hunting community. I never have any trouble filling my freezer with free venison every fall. But the deer population is still four times the sustainable level as set by the state Wildlife dept and local conservation groups.

Hunting isn't necessarily enough to control the population.
git is a beacon of 'do one thing well' and honestly I'm not overly impressed
Because Macy’s may be going out of business like JC Penny’s and Dillards.
Hot damn, an online weather page that doesn't perform like I'm trying to load the radar view over a 56k modem.
It is useful for code readability. When you’re skimming and trying to understand a large chunk of code, if almost all the variables are declared with “const” and then you come across a “let”, you immediately know to look for where it will be mutated elsewhere.
The shot still generally does a great job at keeping the vaccinated from hospitalized.

We're already burning out our primary care enough for some to leave the profession, or worse.

Just because COVID is another risk factor, it doesn't mean we stop taking measures against it. The flu's a risk factor, yet we take flu shots, and don't go out french kissing strangers who's coughing, sneezing and having a fever.
I was in the same situation as you. I found it difficult to design my own that works good on desktop and mobile.

So I purchased multiple themes and settled on Landkit[0], which is built on top of bootstrap.

[0]https://landkit.goodthemes.co/
> you cannot so easily calculate the cost of squandering a chance to have a memorable experience while you're still young and unencumbered.

Do people who do the whole "frontload a big hedonistic experience before you start working/living as an adult" actually end up with memorable experiences that often?
I've never known a hacker who didn't like trains and escalators.
But it's not just about emissions. Throw glass in a hedge, and it's pretty inert: a shiny rock. Throw plastic in a hedge, and it'll drift and get stuck around something, or get eaten by something that really shouldn't be eating it, or break up into tiny pieces and poison the entire food chain… likely all three, and more.
That was exactly what I expected.
Keeping iCloud unencrypted and now the CSAM mechanism. It's not a RAT, but they're very much backdoors.
For those of us with dark skin, the bullseye ring may be there but be imperceptible, making it even harder to diagnose.
Interesting. Thanks for the note.
It's still a death sentence in [some parts of] Africa (as is being gay).

Precision is next to godliness.
And modern data structures always outperform classical ones.

Why cuckoo when you usually use swiss tables or stanford tables for longs? Or https://greg7mdp.github.io/parallel-hashmap/ for concurrent htables?

Learned indices (ie dynamic data structures optimized to the data) usually outperform these as well if they are properly optimized. Which can be neural nets, but also perfect hashes or just better dynamic lookup methods. Like three-way array lookups, properly compressed, as with Unicode. Not everything needs to be a NN, though it helps if you see no structure in the data.
I rarely rely on luck (although I do count myself to be very lucky up to this point). I tend to rely on myself very often, and my one principle rule is that I have every expectation that I will have to do everything by myself. Any help that I got would just be a bonus, but it is still very much just myself. This has been what it has been like all my life and I don’t intend to change.
A couple reasons I can think of:
- The less logic you do on the client means more data required to be sent over the wire.
- Connections are getting faster but we aren't at the point where they're negligible.

For example, if I need to do complex form validation in real time I could send the form value to the backend, have it validate, and receive a response which introduces a lot potential of failure points. Alternatively I could write some logic on the frontend to validate, and this problem expands as the amount of fields in your form increases.
This looks awesome, thanks for sharing! I love "bringing the elegance and concision of Ruby into the browser." I happen to be about to spin up a new project, so I'll give this a shot and see how it works in practice. Cheers!
> The arrival of the magnetic stripe changed all that [...] offering more security...

Is this what we'd call security through obscurity? I was under the impression that data on magnetic stripe was not encrypted.