skysight-inc/HackerNews huggingface dataset:
Here's a full text link [1]. This Letter To The Editor is an incremental contribution to the literature on SARS-CoV-2 antibody dependent enhancement. It does not attempt to quantify the health risks to individuals who have been vaccinated or naturally infected.

> The aim of the present study was to evaluate the recognition of SARS-CoV-2 Delta variants by infection enhancing antibodies directed against the NTD. The antibody studied is 1054 (pdb file #7LAB) which has been isolated from a symptomatic Covid-19 patient.

> Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs

> in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.

> In conclusion, ADE may occur in people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors) and then exposed to a Delta variant. Although this potential risk has been cleverly anticipated before the massive use of Covid-19 vaccines, the ability of SARS-CoV-2 antibodies to mediate infection enhancement in vivo has never been formally demonstrated.

[1] Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?
https://www.journalofinfection.com/article/S0163-4453(21)003...
This is painfully true but also hard to discuss.

Similarly, different musical verses are being censored for one reason (abuse against some subset of gender), but not for another (violence against women). Interesting times indeed…
If your goal is to get usage in those types of workplaces sure otherwise it's obtuse to cater to them not the other way around. Even if you're not sure if you'll ever want it to go into such a place it's not like you can't rebrand your own project (unless you chose to not own it in which case it's not your concern anymore).
That people ignore speech they don't like.
This is my first one so don't take my advice as gospel, I may have just gotten lucky. What I have always done is updated my resume on Monster and linked In and set whatever settings are needed to allow recruiters to contact me. The calls and emails just start coming in then. Sometimes those calls are from people that don't speak the best of English or have a thick accent, those are the ones I have gotten my current job and another really good W2 job with. Helps if you are not desperate to switch jobs. I was able to negotiate a higher wage as I was willing to walk after giving 2 great interviews. Negotiated an extra 30k onto my salary and I get paid hourly OT if I work over 40 hours a week or for any weekend work.
It's really hard to do anything in python without `iter` and `next` - understanding iterators and `iter` in particular is table stakes with python.
WaaS - Washing as a Service is going to be HUGE in 2023! Better get in now!
Explore, build, and host 3D metaverses on mobile, desktop, and VR
All social platforms have one goal: keep you there, so you can see as much ads as possible. I seriously doubt that they sacrifice profit for who-knows-what conspiracy theory.
What is being pretended as true?

That 1 USDT is worth $1 USD.

The entire crypto market is a house of cards built around this fantasy.
https://www.youtube.com/watch?v=Pmh4Uwjo-GE&t=1m

Also, it exists. The people who will go from having to slap clothes on rocks to this wouldn't be as quick to shout "meh, it's been done before"
Animals are shrinking. Blame climate change
It's not that outrageous considering the facts that trickled out, especially this whopper confirmed by FBI: "Florida Governor Says Russian Hackers Breached 2 Counties" [0] In 2016. Also interesting that you don't mention the nearly 20% of Republicans or 40% of Independents who believed it.

[0] https://www.npr.org/2019/05/14/723215498/florida-governor-sa...

==Like there’s actually plenty of stuff on both sides to put together a pretty well balanced unit and I think it would be valuable. But you can’t expect partisans with ideological blinders to teach kids how to be objective.==

What leads you to believe this will be partisan? Is it possible that your own partisanship is actually causing that belief?
Here's a huge list of times the NYT and the other organizations you listed made shit up over the last four years, with citations

https://taibbi.substack.com/p/aaugh-a-brief-list-of-official...
> What can be done to stop Facebook closing down these research projects?

Go back in time and make Cambridge Analytica disappear.

Facebook’s biggest scandal and existential threat came from company siphoning data disguised as a research.

There’s of course a tons of details to it, but it’s totally understandable to me that they’re doing everything to protect against 2nd CA.
Still waiting for this!
Thanks for sharing. As I noted elsewhere, this is how things should work. If you have a smart, hard working person as a low level worker their ability to work hard and move up is essential for a successful society. Companies have moved to a system instead where you need the right degree from the right school to get into the right position.

The MBA types may say that you should focus on your core competencies. Google, being a tech company, running their datacenters sure sounds like a core competency.
> Twitter just wishes you'd do it elsewhere.

Unless you are an arsehole with power and/or influence. Like a certain harassing racist who had a lot of power for about four years recently.

(yes, I know they dropped that one eventually, how brave of Twitter and their ilk to do so once he no longer had significant chance to take retaliatory action)
What about those billion dollar NGOs not funding Bill Gates'es space toilet, or these expensive PVC tanks with handles, but actually trying to do just something on the ground like building a power station?
I meant that instead of passing the array as A or A(1,1) you can pass, say, A(6, 42), if you want to work on the submatrix starting at element (6,42).
The paper has two authors, one American and one from the UK. If I had to guess I'd guess that was from the UK author.

Why? Because in the US ten pin bowling is the only kind of bowling most people are aware of, except perhaps in New England where candlepin bowling is popular or central Texas where nine pin is played. I'd thus expect an American author to simply say "bowling ball".

The UK is mostly ten pin, but in the non-English speaking parts of Europe nine pin is big. I'd expect a UK author to be aware of that and so specify the type of bowling ball.
Ivermectin is incredibly effective. It's just not profitable.

Here is a meta analysis of 63 (so far) randomized double blind trials: https://ivmmeta.com/
They are only a problem if you trying to use your cognitive power to prove mathematical theorems or discover natural physical laws. Which are not things that our brains are designed for.

In all other situations, they are working as expected.

e.g. risk avoidance is very important because one single mistake in risk assessment (underestimating a real threat) can wipe you out.
Nowhere in the paper I read that ADE was detected in the vaccined. Vaccine-induced ADE is only evocated as a possibility.

That's a letter to the editor.. That's an expert opinion and sits at the bottom of the hierachy of scientific evidence.

Furthermore authors seem to be connected to Raoult..
> But the landscape has become a lot more partisan/ideological in the last 10 years, particularly at universities, so I understand why people are skeptical/concerned.

What if the propagandists are portraying it that way, in order to create that skepticism/concern. They do delegitimize one institution after another: Journalism, education, government, etc. - these are the big ones.

> so much unabashedly propagandist content to be pushed out under the guise of "journalism"?

If you are talking about opinion columns/segments, I agree it's there. But most straight news from major sources is impressively straight, IME.
> "where would our technology be if we had continued improving on simple things like the plow, without using combustion engines"

The bicycle, I guess.

Thank god for bicycles. We could use more inventions like that.
So far we haven't seen any evidence of ADE in-vivo. Until that data shows up we shouldn't be jumping to any conclusions based on in-vitro or other computational models.
I am not sure why are you asking. https://en.wikipedia.org/wiki/The_1619_Project

Copy a little bit to show the dishonesty of the project creator:

> In September 2020, lead 1619 Project writer Nikole Hannah-Jones criticized conservatives for their depiction of the project, arguing that it "does not argue that 1619 is our true founding".[12] Atlantic writer Conor Friedersdorf responded on Twitter by citing statements from Hannah-Jones arguing that 1619 was the nation's true founding.[12] Philip Magness said in a Quillette essay that the claim that the project aimed to "reframe the country's history, understanding 1619 as our true founding" had been removed from the opening text of project's page on the New York Times' site without an accompanying correction notice.
Too bad California got duped into passing prop 22, which I imagine would affect these exploitative employment practices.
You are discussing reports to the UK Football Policing Unit, not tweets.

By 14th July, 1,961 Tweets had been removed proactively following the Final, with a total of 126 removed from reports.

the UK was - by far - the largest country of origin for the abusive Tweets we removed on the night of the Final and in the days that followed.

https://blog.twitter.com/en_gb/topics/company/2020/combattin...
I'm planning to become a digital nomad but don't have any ideas about the visas yet. Now, this can certainly give me some insights into the future.
This would have been a huge fear of mine if this was 10 or 15 years ago and legitimate publishers were still engaging in copyright litigation for individual noncommercial pirates. The RIAA stopped doing individual lawsuits because it was surprisingly expensive to ruin people's lives that way over a handful of songs. This largely also applies to the MPAA as well. The only people still doing this in bulk are copyright trolling outfits - companies like Prenda Law and Malibu Media. They make fake porn, covertly share it and lie to the judge about it, sue you, and then offer a quick and easy settlement route.

(Yes, I know, it sounds like I'm splitting hairs distinguishing between copyright maximalism and copyright trolling. Please, humor me.)

What copyright maximalists really want is an end to the legal protections for online platforms (DMCA 512 safe-harbor) so they can go after notorious markets directly. They already partially accomplished this in the EU. It's way more efficient from their end to have one throat to choke. Once the maximalists get what they want, platforms that want to be legitimate would be legally compelled to implement filters, ala YouTube Content ID. But those filters would apply to content that's published on the platform, not just things on your device. Remember: they're not interested in your local storage. They want to keep their movies and music off of YouTube, Vimeo, Twitter, and Facebook.

Furthermore, they largely already have the scanning regime they want. Public video sites make absolutely no sense to E2E encrypt; and most sites that deal in video already have a content fingerprinting solution. It turns out it was already easy enough to withhold content licenses to platforms that accept user uploads, unless they agreed to also start scanning those uploads.

(Side note: I genuinely think that the entire concept of safe harbors for online platforms is going to go away, just as soon as the proposals to do so stop being transparently partisan end-runs around the 1st Amendment. Pre-Internet, the idea that an entity could broadcast speech without having been considered to be the publisher of it didn't really exist. Publishers were publishers and that was that.)
Ah not to worry then as a few of us will get much richer while the planet burns, business as usual /s
they specifically carved out an exemption where hate directed to CIS white males is acceptable.

Do you have a link to a policy or some other written statement that this is the case? I find this difficult to believe without further information on what you are referring to.
Could you elaborate on how the US data is manipulated or why it is lower quality than Israel's?
We don't need to know the details of the algorithm or the models when we can see how it behaves. E.g. the example of one of the other posters where they cite that IG keeps pushing bikini pics over other content. Just knowing that the above anecdote is true empirically via whatever means is super useful and can shape our understanding and push back.
nice concept, however when I select a country I am shown visas that are not available to me. the first step should be a list of where I hold passports, THEN I can select countries that then have their results filtered by my citizenships
Yes, it would be unreasonable. Electrical equipment doesn't scale proportionally to power levels. It might cost 10 times as much to install a 480V connection than it does to install a 240V connection.
Obviously we can translate one Turing complete paradigm into another, but that's not very interesting.

I argue that as so very often C++ the defaults are wrong. You can easily do the wrong thing, or you can go to a lot of effort to do the right thing, and since the right thing was technically possible C++ practitioners proudly declare C++ got this correct, and I say it did not.

[See also: everything about const from West Const being endorsed in NL26 despite being silly, through to the fact that the default is mutable for no good reason; the fact char isn't necessarily signed or unsigned you need to pick one if you care; need to explicitly use a provided replacement for the array type because the default built-in array type is broken; the default meaning of the literal "Hello, world" is this awful NUL-terminated byte array using that broken default array type; Way too many dubious implicit coercions, including narrowing conversions everywhere; I could go on]

Because we're not handling truly exceptional cases we will often want to treat the OK and error cases similarly. We tried to go outside and it was raining so maybe we should get an umbrella before venturing out again, but it wasn't on fire out there so we don't need to freak out and abandon our remaining plans to flee the fire immediately.

Exceptions make this needlessly difficult whereas sum types don't. The exception deliberately changes program execution, that is in fact its purpose, whereas the sum type lets you carry around the error and its context just as you would an "OK" result, until you need it for something or you decide you didn't need it and drop it on the floor.

Bad defaults get replicated for consistency. There are a lot of bad practices -- things you definitely shouldn't do -- that are now enshrined permanently in the ABI of the C++ standard library and so for consistency you're going to inherit those practices.

As a result I agree that Expected doesn't feel nicer in C++ today than exceptions but I argue that's a language defect, in a better language you'd find Expected worked better for the unhappy paths of your program and exceptions remained available for those truly exceptional cases that the programmer did not anticipate happening. Now, one programmer might feel that even "File already exists" truly is exceptional for their scenario, while another considers "Disk I/O error" to be merely an error they can cope with and no big deal (maybe the second programmer is writing an IT forensics program). That's going to vary, but the way for a standard library to reflect that is to use Expected almost everywhere and allow the developer who thinks "File already exists" is exceptional to throw for it, not have the standard library throw everything and then you race around trying to catch what you need to and hope you didn't miss anything.
It was too many years ago, and I was too young for me to remember if it helped me deal better or not. But if I'm still holding on to it, it must mean something!
IIUC the angle here, it’s not that they don’t go to work. It’s that rather than going to the gym, they’ll work out as they do their laundry at home.
Wrt. the Fairphone 3, https://wiki.postmarketos.org/wiki/Qualcomm_Snapdragon_450/6... suggests that mainline kernel support is very much WIP at present, but ought to be feasible i.e. there are no obvious roadblocks to full mainline support. (As for Fairphone 2, see https://wiki.postmarketos.org/wiki/Qualcomm_Snapdragon_800/8... instead.)
Maybe a little remix on that grey - add just a touch of olive, teal, or some other color.. Green LEDs - yes! Blue LEDs is the most obnoxious thing that happened to electronic devices IMO.
AP English is available only to a narrow group of people.

> there's really no way to know how effective it is in reducing ones propensity to be "misinformed" (by whatever measure)

It seems straightforward to research it.
On the other hand, manual laundry was one of only a few common means of self-support for 18th century working-class women: https://www.youtube.com/watch?v=wK9OyW4Jx_g
Of course, but it is never $100 per year.

It is just crazy to me that with all the price increases and increase in income/wealth gap, and increases in variety of diets, that it would still be considered taboo to not want (or even be able to) pay for others’ excess.

I go out of my way to make sure if I am having extra to chip in extra, but I certainly would not look down on anyone that insisted on paying for only what they consumed.
You cannot learn from the government which news sources will give you reliable information about the government any more than you would trust cigarette manufacturers to tell you which studies about cigarettes to trust. Step 1 is abolishing government schools entirely.
This is a great initiative. Interestingly, manual washing machines like this were briefly an incredibly hot commodity in even wealthy suburbs in my home city Cape Town, SA during the extreme drought and water shortages we had in 2017/2018 [1].

They used substantially less water than a traditional Samsung or LG washer and actually worked pretty well. Considering the draconian water rations that had to be put in place people were very keen to speed up washing while still very strictly controlling water use. The local brand that people used was called Sputnik [2]. Now that the drought has broken people often talk about how crazy in retrospect our water usage was before and I even know a few who actually still use these washers because of the efficiency. That said - most folks have gone back to machines now that the water situation is stabilised...

[1] https://en.wikipedia.org/wiki/Cape_Town_water_crisis

[2] https://www.sputnikwashingmachine.co.za
Worth noting that it isn't legal to work on a tourist visa in most countries.
Maybe we have, but without a visual detection, we don't realize what we're seeing in the wobble.
Thanks for letting me know about this, I did not realize. It does not seem to work on iOS devices but they do seem to have browser support!
The first thing I did was check for Costa Rica's new digital nomad visa, which they don't list on this site yet because it just got signed into law a few days ago:

https://ticotimes.net/2021/08/11/costa-rica-signs-law-to-att...

Highly suggested! This country is the best, I've been here for the better part of a decade now and can't recommend it enough. There's fibre to the home rollout in more of the country than I've seen in north america, I don't want to strangle anyone here and the people are so open and friendly, the weather is great as long as you can stand some 15-60 minutes of heavy rain every day during the rainy season. Bring battery backup for internet on a 4g modem and you're good to go for a couple of hours of power outages before the cell tower battery goes out too (Rare that it's out that long!)

Personally I'm up in the mountains instead of the beach because I prefer the climate but it's crazy how little I pay comparatively on rent and food in this part of the world. The most expensive thing here is honestly just electronics -- Bring them in from out of the country because they tax those like mad. People ask me if it's dangerous here, and whenever something bad happens to Puerto Rico my inbox gets flooded with people asking if I'm OK (haha check a map for once!) but pretty much as long as you stay the fuck away from the 10$ grams of cocaine you'll be fine. Don't do that shit in any country, they grind up the bones of narco victims into the cut and it's just a general bad karma magnet. It's my first bit of advice to anyone in the country asking me if it's safe because 95% of the problems I see people encounter have to do with them not being able to heed this type of advice.
It's listed as a washer and dryer. The crank spins the drum which would have the effect of drawing water out of the clothes just like a front loader.
The net gravitational force is zero: https://en.wikipedia.org/wiki/Shell_theorem
A lot of that talk compares theoretical results with experiments in a low-pressure wind tunnel (see e.g., the slide at this point https://cassyni.com/events/6GYLBKG5pBd4su8dm9A9FB?t=255.0s for a reference).

It's quite a simplistic (2d) setup however. I'm not aware of any more complex experiments.
What do you do when that leads directly to murder?
Wow. This is quite bad. It looks like animation from the late 90s.
Will nil == nil be true in Go?
> Calling them “big tech” jobs is almost as misleading as claiming that the construction workers and electricians who built the data enter were “big tech” construction workers.

To be fair, an excavator is a fairly large piece of technology.
I see ideas taking root here where they have played out in other parts of the world.

* … but China argues they voluntarily attend centres which combat "extremism" *

https://www.bbc.com/news/blogs-china-blog-48700786
> Was paying under $700 for the two of us.

What did this buy, though? That premium sounds like either a "health sharing ministry" or some kind of barebones catastrophic plan. Both are smart options if a person has good income and a financial cushion, but they're a much lesser coverage than what most big employers would provide.

> if 1099 is ~25% more than W-2, odds are pretty good you can do better on your own

I've used a wider margin as a rule of thumb when considering it in the past. I'll have to rerun numbers based on my current income and benefits.

> especially if you take advantage of the solo 401(k) to reduce your tax load.

That secret $54k deduction... probably the biggest benefit for anyone who is moderately high-income and retirement-minded.
I found this a thoughtful analysis of some of the more contentious material in the project. To me, it sounds like "factually wrong" is quite a stretch: there's a lot of nuance when trying to interpret history, and the economic impact of slavery appears to be the clearest place where the project overstepped.

https://www.aier.org/article/fact-checking-the-1619-project-...

Do you have other suggested reading beyond the scope of that piece? Too much of the criticism I've found online seems to be attacking straw-man paraphrasing of the project.
I'm not a fan of the gym, as I prefer to stay active other ways, but I often wonder if the effort and energy expended there could be put to better use? This is perhaps an example of that.
> Also note that Moderna and Pfizer were shown to have similar clotting issues

Do you have any links about this point?