skysight-inc/HackerNews huggingface dataset:
So telomerase is slightly different - chromosomes have teleomeres at the end of each chromosome. These are just like long bits of "this-is-the-end-of-the-chromosome" DNA, like when you have a role of receipts and towards the end they have a red line through them to show the end is nigh.

You can think of it as like a "count-down timers". Every time a cell divides, the DNA gets doubled, so one cell doubles its DNA, creating two cells with identical DNA. When this happens, each of the telomeres in the new cell get a little bit shorter by a constant amount, and with this happening in a recursive way at some point they reach a critical length (Hayflick limit). At this point the cell knows it's undergone a certain number of divisions (~40 I think) meaning it's an old cell, so statistically it's likely to have picked up a few mutations. These mutations could make the cell less effective, or even worse, lead to some kind of disease (i.e. cancer), so as a precaution the cell initiates apoptosis. It's pretty clever - there may not be anything wrong, but there's a significant chance there is, the cell isn't perfect at detecting problems, so to avoid the risk to the rest of the body it kills itself.

Telomerase rebuilds telomeres, so is crucial in cells where lots of division is going on rapidly (such as embryonic cells) so cells can divide many more times by adding on the bit of teleomere that's lost. The problem is in cancer cells, telomerase is very often mutated into an “always on” position as it gives cells a way of being immortal. In normal cells telomerase isn't usually active, although it may have some other roles in pseduo-related areas. I was lucky enough to see Elizabeth Blackburn (Nobel prize winner for telomerase's discovery) speak a few years ago on this topic – it's really fascinating.

Proteins involved in DNA checking/repair are ones like ATM, Chk1, Chk2 , BRCA1, BRCA2, Rad51. There are many more, and they tend to work cooperativly together, though I can't remember the others off hand.

For more information regarding this kind of thing I'd really recommend Weinberg & Hanahan's The Hallmarks of Cancer [1]. Although published 11 years ago it's pretty much a “classic”, and gives a good overview of DNA damage and telomerase, albeit from a cancer viewpoint as opposed to generally.

[1] - http://www.weizmann.ac.il/home/fedomany/Bioinfo05/lecture6_H...
> The fact that you even tried it and thought it might be a viable solution just shows your education has failed you

This holier-than-thou attitude is exactly the thing that prevents more people from becoming educated on these kind of subjects. Knowledge and experience on these kinds of subjects are _not_ trivial and are _not_ easy to obtain! Information about what scales, what does not, and why, are scattered all over the place and difficult to find. It may be very obvious to you after you already know it but it's really not. If, instead of spending so much time on declaring other people as dumb or uneducated, people would spend more time on educating other people, then the world would be much better off.
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Evidence... how about this: http://xkcd.com/903/ ?

"Water purification" was this first thing that popped into my head based on your "basic necessities" comment earlier. The article is in fact an extremely good starting point for a competent engineer with no special knowledge of the matter. It describes the issue and outlines solutions, with linked references to further research if needed. And yes, it is detailed enough to help very significantly. I tell you this as a practising engineer with little knowledge of water purification myself. I am surprised you think otherwise.
The post has been edited since I made my original comment, and the tone has been changed.
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I've often thought the key to winning a (conventional) war is simply to make less strategic blunders than your opponent.
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"Instead, he says, firms and government should look at the kinds of graduates that are coming out of the country's universities and offer services based on their skills."

Speaking as a Kenyan software developer, this is a better approach than "the next outsourcing destination". A lot is going on in the mobile app scene, it would be great if more investors focused on that.
Gosh, Google+, who WOULDN'T want to use their real name?
Nothing was removed. I added the last paragraph. (Actually a few minutes before you made your comment, but perhaps before you saw the edit.)
Well you still have the phone numbers of the businesses you called. Call them again and ask them who's handling their lead generation.
That is so kind! Thank you for this advice. I'll pay it forward online....
All said and done - it's fun to work with talented women :). Hiring women just for 'joy' factor is crap. There's one more quality - with the right input, women tend to foster team building and sharing qualities not only in themselves but in their fellow co-workers as well. In a high pressure work environment, this can work wonders.
Suppose you want to count number of books for each author.
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Maybe hyperbolic, which is a little different.
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I have an server monitoring application that does this, currently I've tested on a vm with 4000+ clients with 1 server (all on the same vm), without any errors (CPU load spikes, but memory usage was actually low, I believe ~200MB for the entire test).

4000+ requests being sent every second to the server in total, the server is a single node process.
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Would love to be in the room when this gets pitched to investors.
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I'm not thrilled about the name.

First, it seems pretty disrespectful to use religious imagery, etc., for a commercial product, especially if you are not a practitioner of said religion. This is doubly worrisome by the text that seems to suggest that "zen" (or, rather, Zen) and "Buddhism" are interchangeable concepts. They're not.

Second, if you are a practitioner, you're undoubtedly aware of the large role that lists play in Buddhism-- which means that it's a bit deceptive to have a product named "Buddhalists" (or Buddalists-- see below) and not have the product based on the traditional Buddhist conception of lists.

Third: you don't even get the spelling straight on your own headline. That's scary.
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Ah! This indeed looks good. Thanks!
It means "fuck me" (repeatedly) in Slovenian :) But I guess if Ford* can't be bothered to check it's car names that a small startup will be even less likely to do it.

* Ford Kuga in Slovenian means Ford bubonic plague (http://www.ford.co.uk/Cars/Kuga) ...
I did not downvote you, I was away from the computer for the last few hours. However your comment is so disingenuous that I am wondering if you are trolling. To wit:

- "A lot of the text in that article isn't particularly actionable" - what does this even mean? Does all of the text have to be actionable, let alone particularly so, for it to be useful?

- "...simpler purification solutions could use more detailed information on how to construct them" - no, this would not be appropriate, Wikipedia is not (yet) a detailed manual on how to do absolutely anything. But I think you implicitly admit that a good starting point has been provided.

- "...the information on Wikipedia is not detailed enough to help significantly" - yes, it is, it gives you the background, explains the jargon and provides hyperlinked references into whatever area you might need more information on. Not quite sure what your definition of "help significantly" could be here.

I will not be online for a couple of days, so if I have not convinced you, let's agree to disagree.
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I think the hard part about not doing stupid shit is knowing what the stupid shit is. This advice is great for people with intermediate-to-advanced knowledge of the field they want to "stop doing stupid shit".

Though it is mentioned in the article, I think it doesn't get as much attention, the most important part to this little piece of advice for someone learning something new: Learn what you should not be doing as well as what you should. (People usually focus on the later and not the former) ... A great tip for educators too.
I may have a good solution:

Take two photos. One at the starting position and one at the current position you'd like to save. You don't need to take them in order (take the current position, reset the board, and take the other photo). This way you know what the pieces are from the starting position, then use an algo to match based on that.

Also some good hints for most standard sets while checking your current position...both kings are always on the board and they are usually the tallest. there is never more than one queen per side, and its usually a close height to the king, but has a circular crown. Rooks are circular on top, bishops come to a point, if there are more than two pawns per side that gives them away. Knights could be singled out by eliminating the rest.

Good luck!
We're all pretty capable of being sexist.. me included. I apologise for I calling you out in such an abrupt way.

I can't help wonder how difficult it must be trying to make it in a male dominated environment as a woman. I think that it's vitally important to call out prejudiced behaviour when we see it, and that's what I was trying to do. I didn't mean to insinuate that you are a sexist person, but I did read between the lines and summise that you were inferring that women can provide social purpose in contrast to purpose based upon their skill.

The only reason a person should be hired is because that person's abilities meet or exceed the requirements for the job. To hell with conditioning, social norms and tradional office hierarchies .. if we don't question the way we think or behave - society won't evolve in a positive way.
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Though async event driven programming is somehow confusing in the beginning, there are some idioms that could make your code more comprehensible.

My experience (mostly in perl - EV,AnyEvent, etc.) is that combining evens with finite state machines gives more structured code, with smaller functions that interact in predefined manner.
Edit: Realized you discussed WorkFlowy in your analysis.

I find the name distasteful. Would you be comfortable releasing an app called jesuslists? Same idea.
And if you are a practitioner of another religion you won't feel comfortable using this either.
I agree to this. The nomenclature and messaging seems pretty casual.
Ideas are plentiful. Your's comes across similar to "the next generation of the social web"; that is, "Automator on some drug that made it crazy fast" has nothing in the way of how such a thing might work. Even after thinking about the problem a lot over the years, I don't see how one might build a "crazy-fast Automator" along the lines of what you propose.

Given your background, you likely don't either. You come close to the discussion from http://news.ycombinator.com/item?id=2579668 of "Idea Guy Looking for Developer." Read the linked essay and the responses.

BTW, there are other drugs in Greenland. The average inhalant use is higher there than the rest of Europe, says http://www.espad.org/greenland .
Would I be far off the mark if I thought this is something like org-mode without the Emacs? (And yes, you should get the title right.)
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Google claimed that Android was being attacked with patents.

Microsoft responded that they invited Google to jointly buy patents.

Microsoft is currently threatening Android hardware partners with their existing patents to extract fees. Patents jointly owned by Google and Microsoft would not affect this, patents owned only by Google could force Microsoft to back down.
Congrats, the startup i'm working on http://getdealy.com/creative got to 1000 in a few days as well, but this was mostly by Forrst Ads and telling users we had on a couple of other design lists about the deal.
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This is in no way a criticism of the actual app, but has building a to-do list become our day's "writing your own text editor"? Fascinating how a new one seems to pop up every day.
I'm with on the idea that, on the surface, it feels lopsided - $142,000 in sanctions vs. $489,000 in defendant's legal fees - but AFAIK sanctions are not related to defendant's legal costs. You're trying to tie two unrelated concepts and getting twisted that they aren't more inline with each other. Sanctions, in most cases, are regulated - there's a minimum and maximum - whereas defendant's legal fees are not. The judge hopefully gave the maximum sanctions available.
benchmarking with a "hello world" program... seriously?!

How many hello world services do you guys run in production?
These are nice exercises. That could help me motivate myself to start learning a new language and improve a bit like project-euler did for a bit!
Apart from having a name and style that tries to invoke 'zenlike' feelings, what does the app actually do that makes it stand out? There are 1000+1 todo apps, many of which focussing on the 'less is more' principle. I don't see how this app is different, apart from charging a really soothing $10 per month....
I'd be happy to use my mouse or arrow keys.
what a stupid fucking idiot, whoever wrote that
seems like an excessively designed analog of http://workflowy.com/, which is awesome and simple, and arguably more Zen
The reduce stage explanation is rather poor. Reduce aggregates based on key and does not just mash everything together like the proverbial grinder.
I wasn't being totally serious, but I calculated the top 0.1% of total US population, and then 4% of that, which is apparently the percentage of sociopaths/psychopaths for that section of society. The average across the entire US population is about 1%.
I like the simplicity of this. Like headsclouds, I couldn't figure out at first how to make "sub" items. Due to old habits, I kept trying to hit "tab" to indent a new item.

Now for the hard part. In a previous career, I used to spend a lot of time with marketers. They always used to talk about "share of wallet" and the phrase stuck with me. In short: Unless someone is loose with their cash, there's a limited amount of money they're going to want to spend on online subscriptions (of any kind). Given that your app is actually more expensive than a month of Netflix or Amazon Prime, how do you justify the price?

Note: I'm not saying you need to lower your price, just that you need to be more explicit about the value proposition. Especially because stuff like Tadalist and Workflowy are free or freemium offerings.
I have to agree with you (I'm a Buddhist). Anyway, it doesn't make me feel any worse than what I'd feel of jesuslist or something. The problem is, not many happen to think like me. Some people get very much offended.

So the name won't go well with any serious app.
It seems that you are conflating many separate issues, and using the red herring of Chinese counterfeiters to try to prove something in an unrelated discussion. Long patents, obvious patents, patent trolls, long copyrights, strong copyrights, trademarks, etc. are all invoked in different ways by the examples given here in your and other comments, and a meaningful discussion can be had only when it is clear which aspect of the law is being discussed, and what segments of society the proposed changes will benefit.

Many of the commenters here on Hacker News are innovators in the sense that they are creating new software with new combinations of ideas that have not previously existed. They are also against stronger IP protection, because to date, "stronger IP" has meant ridiculously long copyright terms, broad, non-novel, and painfully obvious patents, etc. Many obvious patents cover things that are essential to the writing of software and have been previously documented by academics, but companies are still using them to demand a tax on the work of true innovators, large and small. A sufficiently-skilled corporate lawyer can paint broad and obtusely-worded patents as covering anything they want in the minds of a lay jury. Patent holders claim to have "invented" things that are considered by programmers as trivial, everyday tasks in their programming. We are not "stealing" their ideas, as we never even hear they exist until a lawsuit comes out of the blue.

I could go on. Such are the landmines facing small, independent and/or open source software creators, and they do nothing but slow down innovation and limit the growth our sector of the economy. Alas, this thread has long since fallen off the front page, so it is probably best left to rest.
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So, the Bush regime would defer this for Obama to get a popularity boost? Doesn't make sense.
It's when the fine people of Glasgow (in Scotland) talk to cows.
Hyperic. It has a open source edition, and you can write autoconfiguring plugins. We monitor some 200 servers with it.
its good you're making money.

1. Without knowing the idea, it may not even be a fundable idea. As they call it a lifestyle business. So this is always the hardest thing to do, Raising is a time sink.

2. co-founder will be hard to find someone to work for equity.

3,4,5 - yes , make some money, and outsource parts that you can. Hopefully your site will make money, and put it back into the business.
hmm...back blaze charges 5 dollars a month to back up my computer with unlimited storage. you're charging 10 dollars a month for unlimited nested strings.

the computer says..........no.

silliness aside, maybe try a forum for busy execs. Might get better input & target customers.
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Thanks for the reply.

It does have a lifestyle business aspect to it, but as stated they are people looking for the monthly option already. So there will be lifestyle + recurring revenue depending on the businesses needs.
The only reason a person should be hired is because that person's abilities meet or exceed the requirements for the job.

That's actually somewhat less clear than it would seem on the surface. It's a tenant of third wave feminism, which I generally subscribe to, and I think is approaching the correct behavior at present, but can't be considered outside of its historical context.

The reason that we have any semblance of gender parity is a consequence of more radical waves of feminism that came earlier. The women's suffrage movement in the United States being a prime example of such. When ending a regime of officially sanctioned discrimination, such as women's suffrage in the west (which only became universal in 1990, when the last canton of Switzerland allowed women to vote), or in post-apartheid regions such as the American South after the Jim Crow Laws were repealed or modern South Africa, there is utility in overcorrecting.

For example, I've typically supported affirmative action, since I believe that one of the precursors to minimizing racism in the United States (and South Africa, where a similar law exists) is the emergence of a strong black middle class. Given that in much of the country there was an effective ban on such for the majority of the nation's history, turning the dials to actively promote such seems a reasonable measure.

Similarly, in countries where there was no strong women's liberation movement (e.g. Germany, where women's suffrage was a side effect of the constitution of the Weimar Republic around the time that women were given the vote in the United States), there's still a higher level of sexism that's tolerated in a professional environment. Again, I draw the conclusion that the overcorrection of the suffragettes produced a more equitable environment that laid the groundwork for the modern third wave of feminism that is more gender-neutral than pro-women.

Since parity has still not been reached, it's reasonable to ask if liberal minded folk should come down on the side of actively bolstering women in positions of prestige or the growth of the black middle class and to what extent. I don't think there's a right answer, and smart, progressive people come down on both sides as to whether or not we're "there" yet.
Previous submissions:

http://news.ycombinator.com/item?id=2837583

http://news.ycombinator.com/item?id=2837693

http://news.ycombinator.com/item?id=2840604

http://news.ycombinator.com/item?id=2842770

http://news.ycombinator.com/item?id=2842969 <- lots of comments
Awesome - thank you for posting that. Just what I've been after for years!
I think 10$ for an obvious weekend hack is quite a lot.
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Works quite nicely, I like it. One small suggestion -- if I push right inside the text box, and I've just come from pushing left, then go back to that item. For example, say I'm looking at the shopping list in your demo. I'm on "get veggies".
I want to add tomato, but I can't remember if I had a "get fruits" category. So I push left, glance down, see that I don't and decide to put tomato into veggies anyway. Then I push right and nothing happens. Instead, where possible, right should move me back, so I can go left-right and be back where I started. Bonus points for left-left-left-right-right-right working :)