skysight-inc/HackerNews huggingface dataset:
I don't know or haven't seen any evidence that polymerase mutations are responsible for the increased R0 of Delta, although it's certainly possible.

What we do know is that the Spike protein is essential for COVID cellular binding.

We also know that spike has mutated between 'vanilla' COVID of 18 months ago and what all vaccines target, and Delta.
This makes sense, because the spike (or S) protein wasn't optimised for binding to Human ACE2 receptors; over time mutations in S (ie with Delta) have lead to increases in binding affinity with ACE2, the result being that Delta is more likely to infect a cell with the same viral load as 'Vanilla'. This would be a perfectly acceptable reason for the uptick in viral loads in Delta and infectivity and hence R0.

We are lucky/the vaccine researchers are smart in that S is quite antigenic (that is, triggers a good immune response, although in a 'natural' infection people will produce antibodies to many parts of the COVID virus), and because the selection pressures driving improvements in ACE2 binding affinity of S have not lead to such a great conformational change that antibody responses are useless (ie antibody-antigen affinity is decreased in Delta, but still effective), our vaccines against the earlier S protein are still effective.

Because of the way evolution generally works, pressures driving S evolution tend to end in a local minima (or maxima, depending on your way of looking at it - i tend to think in terms of conformational entropy so hence Xornot and my use of different terms for the same concept) - or as I mentioned earlier, 'Climbing mount improbable', a term coined by Dawkins in the book of the same name.

It is because it is very hard to get out of these local minima that the human body is full of such oddities, such as an eye that is designed with the nerves in front of the photoreceptors, resulting in a blind spot - it's easier to adapt around the minima to reach a new optimum then it is to reinvent the eye with the nerve in the position that would be logical from a functionality standpoint)

Therefore, it is very very unlikely that the S protein, or the virus, will be able to mutate to a S protein that is so radically different that it escapes antibody-antigen affinity from the vaccines we have today - the S protein would basically have to be completely redesigned, which is really unlikely to occur by the gradual process of evolution. Ie the chances of shaking the RNA coding for S into a new functional protein that works and is a completely new, novel shape, is infinitesimal.

So - basically, total vaccine escape is really really unlikely. Like, number of grains of sand on earth unlikely, if not more so. But polymerase mutations could increase the rate at which the grains of sand are sifted.

It is not something that I personally would lose much sleep over - we don't have any evidence from nature that I am aware of (ie flu virus etc) of highly conserved/selected proteins all of a sudden spitting out a completely new model - basically new diseases that we worry about come from species shifting (ie... let's just say SARS to avoid a debate about COVID origins)
Destabilization of other countries on a shoestring budget.
Unless something has changed with web assembly since I last did browser development, doesn't it still compile down to javascript in the same execution environment with those limitations?
it's happening all over. Might be a little more lax in Cali because of lenient laws/prosecutors on stealing stuff though. I assure you it's happening in urban areas of texas and has gone up 200-1000% the past couple of years depending on the city
Except the available seeds are probably decreasing in quality as well.
the article is about mindfulness and many Buddhist commenters have said the article is not about Buddhism, it's about a perverted form of meditation, but you're here defending Buddhists hijacking that topic and saying that everybody else should move on... not throwing shade, just sayin.
This was a great read, but even better was the link to an article by Nicholas Lovell at the end. I love reading thoughtful analysis of the video game industry. What a goldmine!
SQL Migrations in PostgreSQL
Not what I said. Please do not put words like that in anyone's mouth.
Not a Malthusian, but I’m very worried about the amount of resources we are using. We already lack the carbon budget and farming capacity for the world’s population to live to the standard of an average US citizen. There might be enough space and enough atoms, but we don’t yet have the capability to direct it into sustainable quality of life for all.
Looks like something to do with cryptocurrency.

> You can launch DAOs that automate anything these days and take a small percentage from the users of it. Just automate any small aspect of what people do and auto-liquidate proceeds for USD* so that you aren't accidentally speculating on anything, your users can pay for the liquidation too.
> *Your oracle server/cron job can incorporate a broker's API to get actual USD, your DAO can only get surrogates such as USDC which is redeemable 1:1 for USD at certain brokerages.

> It's a boom town. Anybody can make 3x more than what a FAANG would pay annually, and that's being generous.
WTF? Is this for real? People don't go about killing themselves so readily -- no matter how much they are being ridiculed. Whenever I read about suicides like this I strongly suspect murder and a cover up.
You meant trade deficit, not surplus.
+1 to MQTT for home automation.

I spent years fiddling with zigbee and z-wave and propietary other things from well-known brands as well as unknown brands from amazon. Nothing ever worked correctly for long periods of time.

Now I have binned all that other crap and migrated to esp8266-based devices that can be flashed to tasmota, and have them all talking via a Raspberry Pi running a MQTT server and OpenHab via docker containers. It is now rock solid in terms of reliability - the only failures come when OpenHab's cloud integration dies, and then I have a backup local http server with a javascript based client that just sends commands directly over MQTT. MQTT really was the missing link for me.

OoenHab has been a pain to use, but that is a different story. I'd not recommend it and I'd ditch it in a heartbeat, but sonfar I am in a "aint broke don't fix it" position.
Why does this make you sad?
That's a good point, thanks! Solving it by adding weight-equivalent dummies would further complicate this idea.
It's a pain, in my opinion to switch between accounts in Slack. I've only been able to keep up with one a time, especially on mobile. I realize that is a feature, but I haven't wanted to introduce Slack outside work setting since I didn't think I could keep up.
How to Get Started Doing Fast Backtesting Using Algo Trading Tools
You are getting downvoted, but realistically your approach works. Had to do this myself a couple of times when desperate.
Rust as the most “loved”, and Python as the most “wanted” programming languages
This particular instance is a disaster, no doubt, but the real issue is the bundling of completely unrelated provisions into single bills. It's absurd.
My million dollar app idea-- which I can't write because the OS's won't allow it... is I'd like fine grained control over my notifications. I used to do the Pomodoro thing and found it quite effective-- Id like to apply the idea to notifications as well.

It would work like this:

A list of firewall rules about who/what was able to send notifications. The firewall would be able to bump up or down the priority of a message, or discard them. Including rules being able to match say a regex inside the text, sender, time of day filtering.

And then at some specified interval (I would use 25 mins), I get all my notifications that didn't meet the emergency criteria in the firewall.

The iOS Focus mode does seem promising though.
I was correcting a mistake, and my correction stands, it's really not a matter of opinion. He meant to say that some influence would take place, and he called that tipping the scales, which is not some influence, it's enough influence to change the outcome.

I'm confident that you have misunderstood, I'm not confident of the reason why.

edit: listen, you downvoting stooge, me saying "would not definitely happen" is not the same as saying "definitely would not happen" if that is your mistake, and what I'm saying about tipping the scales is correct if that is your mistake. You are flunking english comprehension atm.
> I'm also confused... who reads blogs but doesn't read the docs?

You've been spoiled by good docs ;).
It says something about their HR systems that it's clear they don't review past interactions before doing this. To me that's a warning sign too - I'm less likely to consider interviewing if a company contacts me again and the interaction doesn't start with a pitch of how this time or this position is a better fit...
I completely agree, I’m not asking for a completely new set of consistent tools, but an end result that forms a consistent set possibly together with some old ones. If it’s the case that you can now work in a consistent set and never use checkout then that is a big improvement.
Are these vulnerabilities actual bugs, or just misfeatures?
The quest to 40 million airline miles: An interview with Steve Belkin
Yes, yes, we all know. It's not like this is one of China's new policies. Tell me something new please.
Good. Maybe it will eventually reach the amount spent on causing brain damage to teenagers.
There is of course a classic xkcd about this [0]. I think these help a little with perspective. But my favourite is the rise in syphilis cases leading early psychologists/psychiatrists to think we were in civilizational decline because so many people would go insane from stage 4. You can read a nuanced and thoughfull take on this idea on page 6 of "The Mind Fixers" which is a pretty academic book about the history of psychiatry.

0. https://xkcd.com/1227/
Pfizer to pay $2.3B, agrees to criminal plea (2009)
A multithreaded, Postgres-based, ActiveJob back end for Ruby on Rails
Sweet corn was cultivated at least hundreds of years ago by native americans, it was never allowed to mature and be used as a grain, it makes up a minuscule fraction of corn production. Tortillas are made from varieties of corn that do fully mature “field corn”, essentially the same as the rest of corn production although there are more restrictions and preferences on which specific seed lines get into human food production.
Did they publish battery capacity?
Show HN: On Marketplaces' – concepts, case studies on building marketplaces
You didn't mention your tech stack. BTW, happy to see you here.
Australian Court rules AI can be considered inventor in filings
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I'm not very familiar with concurrency at a lower level, so I can't comment on your complaints. What Clojurescript provides is considerably better abstractions that in turn get you correct implementations with much less incidental complexity or hassle.
Source: https://gpsd.io/
China's Supreme Court sets limits on facial recognition
also give a read about those green apples. (Granny Smith?). IIRC, all of these are grafts from one single tree. cmiw pls .
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I'd clap harder if Vue weren't so desperate to become React and focus on their own strengths. React certainly appealed to a lot of devs who at best disliked working with HTML & CSS, but Vue welcomed everyone with an excellent gentle slope to gently move devs away from direct Dom manipulation and embrace reactive paradigms. Folks with small shops could now refactor their codebases with relative ease.

If only the Vue team could understand, we don't want React features. We'll use React when we want them. We want Vuejs.
The quest to catalogue Australia's insect biodiversity using AI technology
Instead of copy and paste you could have a POST form on your site to trigger the actual reset (with a hidden field pre-populated from the params of the email link).
Gmail and others won’t touch it. They assume a GET is free from side effects and that it is safe to load your link because of that.
This article talking about this sells it as they managed to get the cost down through 3D printing, I'm absolutely willing to bet it cost the Airforce way more than contracting it out. The cost of a commercial 3d printer with security, to autocad it up, training staff, sending people into the field to measure it.

To have a trained air force employee designing toilet seats is questionable, is that what the military should do? Maybe and the air force should explore 3D printers, so it's a waste that might be worth it. But lets not pretend $10,000 went to $300.

The Air Force’s $10,000 toilet cover -
https://www.washingtonpost.com/business/capitalbusiness/the-...

I wonder if there are any follow ups on what else they 3D printed?
FinTech Trends in 2021 Report
[FREE REPORT] somE of the latest trends in tech in Financial Services.
> Right down to that time when the community cried out about Facebook's odd license clause regarding patents. And they changed it.

Looks like you are remembering things differently. Facebook doubled down on public outcry and even react maintainers gave up on it.

Then wordpress chose to stop its adoption of react in its new editor. And that caused Facebook to change the licence.

The fact a big org was needed for this change, is a major factor for Facebook's distrust.
Why not use podman and run containers daemonless and under specific user/groups
Massachusetts couple suing eBay after employees harassed and stalked them
Russia, the EU, China. Basically every nation or political entity with enough launches to jump start a new launch program. Out of these only the US went with a private new comer. The EU choose to develop a new Ariane launcher, while China went with national program.
>sensible thing that...HN did...is to suggest that downvoting isn't supposed to be a "dislike" button

reddit says that too, as do other discussion forums, to no effect, same as here.
This is normal troll stuff, I would guess. It's like claiming website URLs from known mistypers or something. Someone thinks it's funny.
I don’t think I agree. I can’t think of many tasks I’ve ever tried to solve in programming where moving the work to another thread was the right answer. Usually things are too entangled, or too fast to bother. And there’s so much overhead in threading - from thread creation and destruction, message passing with mutexes or whatever and you need to figure out how to share data in a way that doesn’t accidentally give you lower overall performance for your trouble. I’d rather spend the same time just optimising the system so it doesn’t need it’s own thread in the first place.

The mostly single threaded / async model is a hassle sometimes. But I find it much easier to reason about because I know the rest of my program has essentially paused during the current callback’s execution.
Im planning on getting an old-school non-smart phone to take with me sometimes, just to disconnect without being uncontactable for this reason.
hah, yes, came back to correct my statement. Thanks!
It has to be less, surely. I remember growing tomatoes in the garden as a nine year old pretty much from seeds and just in the soil.

Perhaps a regional thing.
I think they're bred mostly to sit in a bowl in someone's kitchen. The fact that they taste terrible is a bonus because you don't want kids eating your table centerpiece.
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Global warming is breaking our software.

From https://gitlab.com/gpsd/gpsd/-/issues/144#note_633612324

> Until last year, leap seconds had been very predicable. The effect of global warming on earth rotational speeds was only very recently seen, or even predicted. But, yes, going forward, that needs to change.
Docs are often very terse and assume a lot of background knowledge. When blog posts are written effort is put in to make sure a wider range of audiences can understand them.
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So the question is, did the rat traps work or not?
Would I be out of line in suggesting DKMS to be used?

I figure it would be close to mandatory for anyone who wanted to distribute their module to others, without having to tell them to rebuild every time their kernel changed.
I thought the US was somewhat unusual in its lax treatment of illegal immigration. However lying to or sneaking past border officials to enter a country is literally a crime yes (certainly for foreign nationals, and probably not kosher for citizens to do either). Though entering on a visitor visa and overstaying is just a civil violation with a civil penalty (deportation). If a citizen had a record of using false identity documents or trying to evade legally-enforced border crossings, a fair algorithm would presumably have to take that into account just as well.
> I don't think it's worth doing all these tweaks.

I feel like i can understand this point of view, since following all of that advice indeed would be cumbersome. However, at the same time you definitely have to consider what it is that you're running on your infrastructure. A small internal system or even an ERP that's not exposed to the internet will probably give you more leeway in regards to being able to ship stuff now, without spending bunches of time locking everything down, especially if you build all of the containers yourself. On the other hand, a large finance application that is publically accessible and needs to weather thousands of attacks daily will probably need a rather different approach.

Overall, however, i'd say that it's good to have lists of tips like these, because figuring out all of it alone would take a whole lot of time. That said, even in the more relaxed environments, it's generally a good idea to consider at least some of them, for example:

> Unless you are very confident with what you are doing, never expose the UNIX socket that Docker is listening to: /var/run/docker.sock

Being an early adopter of Docker, i once made this mistake on a throwaway VPS. It took less than 24 hours for it to be mining crypto. That said, the socket can be a good option for tools like Portainer (which implementations like Podman miss out on), yet it definitely should never be exposed publically.

As always, security isn't a boolean of on/off, but rather is a sliding scale of sorts - figure out the risks that you're likely to be facing and choose the appropriate means to combat them. Of course, it would be better if Docker provided safer defaults, too.
Vue 3 has composition api which is more typeo friendly.

And Pinia is a vuex alternative which has good typescript support. Vuex 5 will have similar api as pinia
Show HN: Find readers to discuss literature, together- books, articles, research
Some of it is just size, as in the larger sized produce might have a similar amount of nutrition per unit (per tomato or per berry) but not per pound, so the nutrition is diluted with fiber and water but still there.

Though there are also a whole lot of edible plants out there that don’t hold up at all to distribution, if you aren’t picking it by hand and eating it the same day it will be ruined.