skysight-inc/HackerNews huggingface dataset:
I think the subscription/"free trial" concept is a particularly hard sell for this. Maybe micropayments would be much better suited as a default: pay $1 right now via Paypal to have a video transcribed. Subscription optional for recurring customers.
Separating out Grail allowed the company to take on outside investment, much of which I imagine flowed back to Illumina in the form of sequencing instrument and consumable sales.

The IP that Illumina is using the block the sale of MGI instruments expires in 2024, I put together some notes on this here:

https://41j.com/blog/2021/05/the-next-few-years-in-dna-seque...

There will probably be a drop in sequencing costs at that time, as there are a few players set to build on expiring IP. Singular Genomics (recent IPO) is one of these, they could possibly be on the market earlier than this (by avoiding some of the last IP to expire).

There's no non-commercial exception for patents, so I don't believe patented approaches could be used in clinical trials. But on the scale of clinical trials, Illumina sequencing would not be prohibitively expensive...
https://puri.sm/posts/anbox-on-the-librem-5/

(It's not the Pinephone, but another GNU/Linux phone. Should be similar apart from the performance)
He's not just living off trash. People give him food too, his friend has spent money on him for things like printing his book. He's indirectly using cash.
I admire his resolve, though it's not something I'd like to take to the extreme. Spending more time with people who have less money (e.g. CouchSurfing -> BeWelcome, hitchhiking, dumpster diving) has been an immensely rewarding experience.

Last week, I heard a message about investment, which said that the 3 ways to store wealth are stocks in companies, bonds in governments, and property (owned by banks or rich people). A few days later, I read about GitLab making it their policy to help people get visas (shouldn't that be a government choice?). Privatisation is also taking over police departments, prisons, bus services, etc. I don't trust that the shareholders' best interests are the same as the needs of the people. War helps private companies, at the expense of governments & property. I'm not hopeful for peace in the next 50 years.

What about investing in people? Not saving wealth, but giving it away!

People will try hard to save their own lives in a war (and if I die, I don't need the return on investment anyway). It's a personal contact, so I think it's highly resistant to inflation. Building community is, in my opinion, more important than storing up wealth. I guess this view is similar to 關係 guanxi. It's democratic: if I do something silly and lose face, then it has consequences. I don't think it's authoritarian communism, where 單位 dictate who you can marry or what kind of job you can do, but a community-focussed lifestyle where newcomers are welcome, and share freely within the group. I'm still trying to figure this concept out though, so other suggestions of philosophical readings are welcome :)
This probably disproves the hypothesis that consciousness shapes reality, because if it did, the millions of brainwashed people watching movies would have turned the reality into a set of movie tropes.
Have faith, things can change rapidly in the right way too.

loads of resources available

loads of brains

manpower

when people realize and decide, you can flip a lot in few time

it's just the usual society blur and inertia that made people like you unable to do more.. many people tried but you can't carry the world on your shoulder so most people resign

get ready

ps: in dense cities, whenever possible, use your bike; we should make viral vids for bike rallies or bike days, it's 100+ % benefits for everybody in a week
Screening breast cancer through AI
Does anybody have any practical use cases for this? I am wondering how this would be preferable to something like sidekiq in a large application with multiple application nodes.
From a peon^Wworker's point of view, there may not be much of a difference between a medieval fiefdom and a 19th century company town. The term "robber baron" is apt.
Let's just assume this works as advertise, at less than 1/10th the cost of lithium-ion. And we can scale it to practically infinity. And available by 2023.

What is left missing in the big picture for 100% clean, and renewable energy? As far as I can tell, Solar and Wind has already achieved cost/Wh lowered than all other form of energy and has a decent roadmap to further drive down the cost by another 50 - 60%.

Or are there some other puzzles we dont know? Or if Iron Battery works, and this will be "it" ?
Are you sure UTF-8 is the ideal format? After all, we have grapheme clusters that cannot be rendered as text units using UTF-8. Maybe UTF-8 is already obsolete and never took over the world? I am more than sure that soon we will see the new Unicode format ;)
> More generally, perhaps measuring dollar-of-GDP-per-gallon-of-water or some such may be of some use to prioritize which crops should be discouraged may be worth examining.

The normal way to "measure" and "discourage" such inefficient things is by prices. However, the price of California water is inordinately cheap so long as you are dumping it on the ground in the desert.
He would live just as well if the people around him didn’t spend money and lives like him, so that’s not his choice
Wouldn’t be the first time he’s done it, for this very topic in fact n
Nyxt is a new interesting browser. WebKit engine but configured by lisp under the hood, and fully keyboard controllable with emacs, vim, or cua controls.

https://nyxt.atlas.engineer/
In the UK, there's a great example of a late-19C/early 20C "model village", called Bournville, created by the Cadbury family to house workers for its factory. It was quite visionary in its day, and remains highly desirable.

https://en.wikipedia.org/wiki/Bournville
I think we need to reconsider the definition of a "vetted library". It's only because I spend a lot of time in this space I'm aware of at least three different libraries that default to unauthenticated CBC mode, and choose key sizes magically based on input (hint: it never ends up what people expect).

But those libraries show up recommended on forums and subreddits everywhere. And if you inherit such a system and try to do something like "add an HMAC", you'll be cursed at for "rolling your own crypto" when you should apparently be trusting the library.
Agree on the high refresh rate point. I used to have a 1080p 144 Hz monitor and it transformed online gaming, but was also noticeable on the desktop.

However, I then went 32" 4k and can never go back. 4k is simply amazing, and today you still have to choose: either high Hz or high resolution. You can't (reasonably) have both, and I choose 4k! Looking forward to the day 4k 144Hz becomes reasonable.
It's snappier than the Pinebook, even if the clock speed is from the 1980s. But the comparison was more about the build quality.
> Some folks are trying to kill ASN.1. It is probably an awkward moment for that, when people are looking at binary encodings more because JSON is boring and doesn't stand out on a CV. It's got all the hallmarks of old tech that looks like it's survived on its merits, but it really isn't like that.

I think it's rather more than this. ASN.1 is deeply embedded in daily life: 3G/4G/LTE/5G, V2X, and many other protocols are specified in ASN.1. The inertia has as much to do with backwards compatibility as anything else. If you need to read call data records, you have to parse BER; if you want to deal with vehicle to vehicle communications you have to parse OER. 3G protocols are generally PER. Crypto is DER.

Are there alternatives that are better in some respects? Sure. Are they likely to supplant existing telecommunications standards? No. Should move away from ASN.1 for crypto purposes? Probably, though I'm not experienced enough to have a strong opinion. I'd be interested to see whether we could install a new standard in a suitable time frame, and indeed what form that would take. (In the two links you cited, I didn't see anything, but I'm actually really interested!)

I think ASN.1 is probably here to stay for a long time, and not merely as a resume polishing agent.
For me, the killer feature is that pinephone runs mainline kernel.

According to https://wiki.postmarketos.org/wiki/Devices - that's a rather uncommon thing to have, and pretty much unobtainable for a recent device (other than pine64/librem5).
sounds like he should apply for the next YC batch
> past experience with hardware projects that rely on compiler changes is that the compiler changes aren't performing well enough in practice.

> Another example is that Apple's M1 proves that wider frontends are possible in traditional architectures, as long as the instruction size is fixed.

Doesn't the M1 prove that you can transpile code from one architecture to another and gain performance benefits? As in, Rosetta code works at comparable or better speed at far lower power consumption?
I don’t get it though. WSL2 has been perfect for me this far. I can’t think of something I need Linux for anymore.
That’s still not the entire state government, and that doesn’t mean that the environment was a top priority for most of them. The point was that farmers have a lot of sway in Sacramento and any significant water usage reform would require serious commitment unless the situation has reached a point where everyone sees a need for change.
This. I have a Ryzen 7 3700X-based machine [1] with the factory CPU cooler, an SSD, and a quiet system fan. When idle, it's inaudible even with the exhaust fan facing you. When I'm compiling, the fan speeds up but you can only hear a quiet ticking. Any quieter would have had no value for me.

[1] https://pcpartpicker.com/user/dtgriscom/saved/#view=P84p23
To hopefully reading most of our messages.
Finally. Wake up many times by different birds and really want to Id them … try it tomorrow see whether it works in Asia.
Of course at some point some people will have to implement crypto.

But I think a good way to think about it is this: This shouldn't be on top of your list when you learn crypto. Before you even think about rolling your own crypto you should break other people's crypto. That'll help you to gain deeper insights in how the whole thing works.

(Disclaimer: I broke other people's crypto, I wrote papers about it. I still never tried to roll my own crypto.)
> I also hope there will be... more resources to excavate, understand and and display all the historical sites found in Turkey

I completely agree. I wish there was an international scientific funding body like the NSF. It could, for instance, provide grants to fund regional archaeology. Life is not easy for scientists in countries that don't fund it. It could be such a good thing for the world.
I agree. Even though money is bad, I believe that it's excusable to help others.

(No, the ends don't always justify the means. In the case of community and the greater good, my moral expectations on others are much lower than the strictness with which I judge myself, and I will break my own rules if it means being a better guest/host).
That part of the write up means that he is still young.

The older you get, the more you appreciate larger monitors, which allow you to continue working without needing glasses and without visual fatigue.
When will we get secure cars...

When will we get secure nuclear power plants...

When will we get secure vaccines...

When will we get secure cars...

When will we get secure planets (without fires,floods, earthquakes, etc.)...

Bla bla bla.
I just wish there was better musl or static linking support in the Linux ecosystem for Alpine. A lot of one-off binaries in my experience were dynamically linked only for the latest Ubuntu's glibc.
IAM "Should have been called Users, Keys and Certs"

That's funny. Because we have hundreds of developers using AWS every day, using IAM all the time, and never using a single IAM User.

IAM is actually named extremely well. identity and Access Management. I can't think of a better name. And if your problem is that you just don't like acronyms, you probably picked the wrong industry.
There's lots of work and innovation to do on those simplifications. It's just a 58 year old person is not able to be as innovative as he was at 30 because of health reasons, and getting tired of hard working. I'm 40, far over my peak because of a chronic illness, but at least I invested my money well enough to live off of it.
Although the comment was written as a half-joke, it's an incredibly obtuse and specific South Korean reference that others might not know, and I thought it would be fun to post about it.
Plenty of QFN chips that die often e.g. charging chips. They are extremely easy to replace.
Pelagia Noctiluca (mauve stinger jellyfish) attack the Greek beaches
The same happens sometimes when trying to download netcat and almost always when downloading any of the SysInternals password recovery tools. Cybercriminals use these tools in attacks and so they must be malicious! You know, like bank robbers use hammers and cars...
I was bullied a lot in school and then I quit going to school and started staying home and never felt worse in my life.
A new approach to create APIs
> The article seems to contain nothing that would qualify for the words "Company Town". It appears to boil down "look amazon is big, surely it means that it must be evil!".

I guess this is the difference between a literal v. figurative interpretation of the title. The article itself is speaking to Amazon's efforts to sustain its hiring pipeline in the face of colossal churn, describing activities such as sponsoring secondary schools while installing their own branding as a condition of sponsorship.

> > A dozen students sat clustered at work tables inside an air-conditioned classroom, which was designed to emulate the inside of an Amazon facility. On one wall, Amazon’s giant logo grinned across a yellow and green banner. The words “CUSTOMER OBSESSION” and “DELIVER RESULTS” were painted against a corporate-style yellow backdrop. On a whiteboard, a teacher had written the words “Logistics Final Project,” and the lesson of the day was on Amazon’s “14 Leadership Principles.” Each teenager wore a company golf shirt emblazoned with the Amazon logo.

> > Students and staff members expressed pride in being associated with the company. Amazon partnered with the school as part of its five-year anniversary in the Inland Empire, donating $50,000 to start the pilot program, the giant sweepstakes-style Amazon check displayed prominently at the classroom entrance. The students had already taken field trips to tour the nearby Amazon warehouse.

> A public high-school classroom designed to resemble an Amazon facility, with students wearing Amazon logos on their clothing as they memorize Amazon’s leadership principles (which, it is worth noting, also include “Ownership” and “Think Big,” injunctions that hold merit for readers of this magazine when imagining how we might solve the problems exemplified by Amazon). Such a relationship between the company and public goods like a high school is part of what it means to consider Amazon as “the major working-class space of suburban and exurban socialization.”

Further (and quite interesting) reading on the concept of a company town: https://en.wikipedia.org/wiki/Company_town
I like reading Casey's rants about modern software and modern software developers because, like him, I have to deal not only with garbage software as part of my day job, but also the people who defend it. How anyone can look at today's hardware compared to that of the 90s, and today's software compared to that of the 90s, and not be furious about how bad software has become, is beyond me.

I can emulate Windows 95 at full speed in a web browser even on a mediocre 2021 PC. That VM will often have lower latency for user interaction than the native UI. How is it we are not all deeply ashamed of our industry?
Star Wars Characters Realistified using Photoshop. Drawing into Reality
> We further compare our findings with non-cryptographic systems, observing that these systems are, indeed, more complex than similar counterparts, and that this excess complexity appears to produce significantly more vulnerabilities in cryptographic libraries than in non-cryptographic software.

This, to me at least, seems like a strange conclusion for this paper to reach. While there are evidently more vulnerabilities reported in NVD/CVE for cryptographic libraries, does this necessarily correlate with a larger number of vulnerabilities being present? Or could it be that cryptographic code is much more heavily scrutinised, and so it’s more likely that vulns will be found? I think the former is probably more reasonable, but I’m not sure you can come to either conclusion based on CVE data alone. Or am I missing something?
I think everything you said just pointed out how bad it really is in the field. You either have an acronym, which people assume you know, or nonsense words.

Boring descriptive names are better, but don't look as good when marketing the product (I'd assume).
Half-OT: What's the reason rationals aren't used often in programming?
They can use any money they want, but if they choose to use PrimeDollars (tm), they will earn a 5% discount and free shipping on all purchases!
> Also, Agile methodologies tend to assume you are in close contact with the customer, who can tell you what they actually want and decide how things should work.

Yes. Kinda :) But the issue isn't want. The friction is actual make-an-impact business needs.

It's easy to sit around a conference table and spitball wants. But trying to bin that person or group down to specifics as well as resolve disconnect and inconsistencies between the ideas and faces go blank.

Customers want the luxury to spit out wants without having to take the time to knuckle down and do the hard work of defining needs. They have a "you figure it out" attitude. That leads to assumptions. And assumptions lead to dysfunctional product / features, for which the engineers get blamed. Again.

Agile is a worthy solution to this problem, but when IT is treated as a service provider and not an equal partner the tool (i.e., agile) gets mutated to a point it's not truly agile anymore.
Ask HN: Music streaming services which cann be browsed by newest uploads?
Hello. It might be so weird question, but I'd like to browse my favourite genres by newest added tracks or playlists added by community. If there are no such streaming service, I will be thankful for some link to website that collects only metadata, and I will search these tracks in Spotify or YTMusic for example. Thanks.
At least I guess writing a control code for my dell 24 inches under mac is much difficult cf to *nix.
Graveyard listing of some failed startups. https://www.failory.com/cemetery.
Why do some people keep trying to prove Bitcoin as a pump and dump scheme? Yes it has pumps and dumps, but if you zoom out, those pumps and dumps get smoothed out and you see a digital asset which keeps increasing in value because people see it as a hedge against USD and other currencies inflation. The increase in value is not infinite, and that can also be seen in the price increase curve (log). The price increase is slowing. Why is it difficult to come to the conclusion that initially Bitcoin price increase will be volatile and eventually it will come to parity, decreasing the volatility. From that point onwards, the price will be more closely related to actual inflation (world over).

(The above purposefully ignores the other debate about electricity, usage, etc. to keep the discussion simplified.)
Yeah this person I don't think understands what school is like at all. Boys were getting bullied for the exact same stuff that girls were getting bullied for, sometimes even by girls themselves. I can't stand when adults who haven't been to highschool in 20 years try to make vast generalizations about something they have absolutely no clue about.
> by living a 40 minute commute

I mean, that's 2 hours commute everyday or 700 hours per year wasted on commute. That's almost 3 months worth of work wasted on commute. I'm not sure if you are thinking about it.
> you would want to integrate a number of preparation steps with the sequencer

I think this is unlikely, Grail like everyone else probably just do standard sequencing runs with their own prep.

The issue is that Illumina make something like 10x on sequencing consumables.

So if Illumina were to sell a sequencing based test, they have large margins they can cut into to undercut anyone else.

That said, Illumina's dominance in sequencing is probably ending in ~2024 anyway (when basic patents expire).

Grail is not Illumina, it's a spinout that they want to acquire back in. Most likely this is because Illumina see that:

a) This Grail experiment is working out.
b) They're going to lose their dominance in sequencing, and they want to acquire downstream applications.
Even the phrase "company town" itself does not signify anything evil. In fact I'm wondering if such a place might be better than the usual government administered cities and towns.
I agree with you that it is not possible to both fix the feature set and fix the delivery date and expect to consistently succeed. But it is also not possibly to tell upper management, who are dealing with a whole other set of difficulties, that they have to pick a feature set or a delivery date and that's all there is to it. If you do that, they'll reject your advice, and find someone else who'll give them a more palatable message.

The best I can come up with is the notion of a double contingency plan. Engineering agrees to a set of functionality to be delivered and a delivery date. This is inevitably going to be a bit optimistic, because people consistently overestimate themselves.

To deal with that, the first contingency plan addresses the question of what should be done if things are not converging to the ship date. The plan here is to keep the ship date, but ask hard questions about what bits of functionality actually need to be kept. What are the actual P0 - MUST HAVE features?

The second contingency plan addresses what is to be done if the first one fails. At this point engineering has already done all they can. They have pushed as hard as they can, and they have deferred every feature that is deferrable. They are down to the actual MUST HAVEs. Now the rest of the organization has to figure out what to do with a product that is inevitably going to be late. What is the alternate ship date? What customers are going to be really unhappy. And so on.

It seems to me any large engineering project should think out these contingency plans in advance. What will they do if making the deadline starts to look daunting? And what will they do if making the deadline turns out to be impossible?
Am I missing some context here? Why is there a 2021 in the headline ?

Edit: Covid and partial lock down has been going on for far too long I read the headline thought we are already in 2022. I had to check the calendar just to make sure we are still in 2021.
China scientists discover giant viruses in the deepest place on Earth
Swap the word “the” with raisin. “To” with cat

It makes following raisin conversation quite difficult. Raisin cognitive load is upped significantly trying cat keep up raisin conversation.
JFYI, you could try this (multi-tab):

http://multicommander.com/

http://multicommander.com/docs/browse-registry