skysight-inc/HackerNews huggingface dataset:
Thanks for that - I can see why my comment was downvoted now, as the the posted article's FAQ lists these links for those who would like to study their favorite sequenced-but-unmodeled protein. I'm glad Alphafold is as open source as it is, and I recognize that it didn't have to be so.

I think I was primed for a knee-jerk reaction because when Alphafold's results were announced back in Dec. 2020, with expressions of what a boon it would be for researchers around the globe, I anticipated there would be a timeline announced for exposing a tool or for the open-sourcing. (The Github repo has only just been released about 6 days ago ...)

With all the work on SARS-CoV-2's 'interactome', as well as human proteins & enzymes involved in pharmacology of antiviral drugs under development / repurposing , it's easy to imagine that drug developers would have liked to exercise Alphafold as soon as it was announced. (I myself have wanted a structure for human enzyme OATP1A2 that wasn't available on the PDB for such a drug pharmacology study - quite glad it is available at hand now.. .:) ).

Anyway I'm sure good arguments will be made about the need to really 'get it right' before releasing, or internal deliberations on how much to open up vs charging for it.

But 7 months lead time during a pandemic is a long time...

In all cases thanks again for this innovation's availability now. :)
LOL! great comment thank you!
I think fitness and marketing experts could be interesting.
add-libs is definitely still on the future list!
Villa 350 m2 proche de la mer Sèmè-Kpodji
What you describe is equity distribution. It is a tax, but simply implemented as inherent ownership through citizenship or similar constraints.

https://blog.samaltman.com/american-equity
Sure, and this is great. But The newest release is 8.0.26, so there hasn‘t been any minor release yet - in 3 years. And i can‘t find anything about new MySQL features or planned features except the big 8.0 release.
The article talks about this in good detail and why hype leads to:

1. Brain drain of talent

2. Ponzi schemes

3. Damage to the reputation of science
Prevalence of smoking tobacco is also dramatically higher among schizophrenic people [0]. Before marijuana use is demonized for causing schizophrenia, it would be worthwhile to more robustly prove these results.

[0] https://pubmed.ncbi.nlm.nih.gov/19794359/
Binlog incompatibility makes migration a lot more difficult at scale.
> Physical and cultural evolution don't stop.

If someone lives forever, they don't evolve physically. This is basic. To the degree we evolve culturally, most of our culture comes to us in our eponymous "formative years." Leaving those behind tends to result in comparatively little change in culture over the remaining course of our lives.

> Selfish immaturity? It seems that you yourself is a reflection of culture.

I rest my case.

> One of our very first epic poems, the Epic of Gilgamesh basically railed against immortality and accepting one's fate.

This was not a call to try and live forever, this is a call to live boldly, take risks and not to fear death. Striving for immortality is the absolute opposite, the coward's response to the challenge made in the poem.
What exactly does 4.6B-year-old mean?

Landed on the Earth 4.6B years ago? That doesn't sound right, the Earth isn't that old.

Flew off its former body 4.6B years ago? How do we measure that?

Created 4.6B years ago? How does one define created, considering everything was ultimately created during the big bang?
Good work Alias team.
Not 100% sure but it seems clickbait - the title sounds like the meteorite was sitting on Earth for 4.6B years, but after reading the article, it sounds like the rock was 4.6B years old - it likely fell to the Earth much more recently.

In that case, it's not exactly remarkable - I think pretty much all the asteroids in the Solar System are 4.6B years old, because that's when they were all created.
Idiotic, the buyer should´ve payed attention.
I'd be interested more in what features were in their (3):

> Non-MyRocks Server: Features in the mysqld server that were not related to our MyRocks storage engine were ported.

i.e. things that they haven't shared with the MySQL community but aren't related to the storage layer. Why would/should they keep those private? Considering that RocksDB is open-source, clearly it's unlikely it's because they're 'trade secrets'.
Looks awesome and the concept is great.. One comment, the first person I clicked into, ralph-merkle, the most recent content is dated October 1st, 2021 then when clicking the link shows a paper dated from 4th Quarter 2008.
The work on reducing dark mode contrasts seems valid.. lots of dark mode is way too high contrast. It's trendy, so I try it, and pretty immediately can feel the contrast messing with my eyes. So it gets turned off.

However I hate the ever increasing emphasis on design that doesn't even care about actual usability. It's all about the shapes and styling of elements and so much less on how all the components fit together, how the user moves through the application, etc..

I've been at this a while and used to be a UI guy, it feels like the balance of design:usability has shifted further towards design than at any other time since I've been using a computer. In places where there used to not be a "designer" flow and usability could end up being emphasized more than it is today. Today a designer sits there and restyles the widgets, in the past with no designer everyone else was happy to take the stock widgets and follow the design guidelines from MS or especially Apple. No thought on restyling widgets meant all the UI design time was on the usability.

Thankfully the project I work on right now has a good balance. Prior to our current UI designer we had a design-first person and it was kind of a disaster, stuff was getting restyled while UI requests from customers to fix usability issues were left to wither and die.
Sorry, I misunderstood.

> The treaty has been claimed to be one-sided[3] because it allows the US to demand extradition of British citizens and other nationals for offences committed against US law, even though the alleged offence may have been committed in the UK by a person living and working in the UK (see for example the NatWest Three), and there being no reciprocal right; and issues about the level of proof required to extradite from the UK to the US versus from the US to the UK.[4]

https://en.m.wikipedia.org/wiki/UK–US_extradition_treaty_of_...
You're comparing a guy who took pictures of people in an Apple store to a child murderer? I have difficulty with this analogy.
Depending on how heavy and dense, the crust can indeed melt but above a certain side the middle does not always get that hot, esp. if not very heat-conductive. This one looks rather porous and light, so likely slowed down very quickly. That's my understanding anyway.
It was acquired by a huge company that sometimes kills products. Shortly after the acquisition, the downloads were removed from the website. It did go open source "recently" though which made it longer lasting, but I'd understand if someone would think it was dead by now.

- https://news.ycombinator.com/item?id=9259986 - Apple Acquires FoundationDB - March 24, 2015

- Comparison between March 25 and March 14, 2015 - https://web.archive.org/web/20150314231702/https://foundatio... (14th March) > https://web.archive.org/web/20150325003252/https://foundatio... (25th March)
Automate Data Validation with DVT
you say it "speaks volumes". Post bad things you've seen and name names. Don't be cowardly
I really wanted to know how they managed to find it, but aside from some offhand comments they didn’t go there.

Found in imprint of a horseshoe? What? Tracking it before it landed?

Like in desert areas people will metal detect for meteors, but how did they find this one.
Researchers Have 3D Printed a Soft Robotic Hand That Can Play Nintendo
> No reason to be wary of recreational use. No more so than you might of caffeine

You should be wary of caffeine use, especially if your culture does not have any rules about its use, or complete enough understanding about its effects. We like drugs because they work, but the problem is we do not know what they do over larger timescales or how to fit them into your life.
Weed is a relative newbie in the average American's life and we would be silly to not respect the drug enough to be wary.
To be clear, there is science that is compatible with THC increasing the risk of psychosis (and perhaps that CBD is protective). I would agree that some are self medicating, but the data also shows that dosage, THC/CBD mixture, and age of use each elevate psychosis risk over random controls [1][2].

It would be great to do double blinded experiments to test this more definitely, but we don't due to unethical reasons. I think the differential legalization will provide useful data along those lines, though it will take some years.

I also think it's important to distinguish between THC "exacerbating" an existing mental illness and triggering psychosis in otherwise healthy people who have a predisposition, due to genes and early life experience. We still don't have a clear idea exactly how to say who's predisposed. Plenty of reasons to take caution, in my opinion.

[1] https://www.nap.edu/catalog/24625/the-health-effects-of-cann...
[2] https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0...
Ask HN: Not offered, asked why, then offered a position?
I recently applied for a position that I thought would be a great fit. I went through a few individual interviews and then proceeded on to a panel interview. The entire process I thought went very well and it was the first time I really got excited about a new job in a long time. Nothing caught me off guard or caused me any concern form both a personality or technical perspective. I was really pumped and waiting to hear back from recruiter. A few days later I received the classic rejection letter about moving forward with anthor candidate that was a fit. I was totally blown out of the water. Personally that probably sounds familiar to a lot of people and I have been passed over for roles before but in this case I really wanted this job. And for the first time I was going to respond to the email and asked the recruiter for any insight on why I wasn't choosen, professed how much I wanted the role and why I would be a good fit. That email was sent about 20 minutes after I received the rejection.

Within 15 minutes I receive a call from the recruiter telling me that they would like to offer me the position. I was like "What"... Again I'm in total shock.... He jumped right away into the offer details that I would be recieving and never once mentioned what had just transpired. So once he was done I had to ask why did you send me that rejection letter? Was it a mistake? He said no. "It was a test to see how much you wanted the role".

I've never heard of this tactic before and my emotions were all over the board during the call so I left at that. I haven't switch jobs in a few years so this is all new to me. Is this now a common practice? In hindsight I'm so glad I went back and asked the why question. Had I not and just blew it off it would have been a huge opportunity loss.
Sounds ridiculous that our pre-linguistic ancestors would not have conscious experiences of colors, sounds, dreams, etc just because they couldn't put them into symbolic form. Seems like a case of putting the cart before the horse. Language is relatively recent. The parts of the brain correlated with consciousness are older.
If Hacker News lasts for hundreds of years, people may look back on this thread as an example of how some were on the right rack and some were heading to a dead end.

"Leucippus and his pupil Democritus proposed that all matter was composed of small indivisible particles called atoms... They are constantly moving and colliding into each other."

https://en.wikipedia.org/wiki/Atomism
I think shared equity is one way of solving that problem, but if you look at other social democracies, regulatory regimes that favour workers and collective action can have similar effects.
Full disclosure - I'm CEO at Percona :)

oh hi. big fan of you all. xtrabackup and PMM are wonderful tools
Weird Programming Facts
Expressed bigotry, typically.
I'm no geologist, but I'd guess nothing can survive anywhere near 4.6B years on this planet with weather systems.
Thanks for sharing! Those must be exciting times. I remember tweaking the fonts only once for printing my diploma thesis back in the 90s; but contrary to the most opinions, I made the fonts even lighter, because of the ultra white paper, we were obliged to print to. It was a very big file due to the 1200dpi rasterized fonts, but the result was better than any print shop could produce at that time.
Sure but the entire point was that they’d have to pay for that privilege. Presumably you could make subsequent blocks exponentially expensive.
By the fade-out of your comment, it seems your accurate assessment of this individual's bloviation is insufficiently self-important for the HN crowd. This is why I never post here. Worse comments than Slashdot.
If we can't explain consciousness in terms of physics yet, then clearly it's not like circulation, since we can explain that in terms of physics now.
I actually do pretty mundane, boring stuff with computers - web dev, some finance & trading, lots of backend. It isn't all that exciting to an average person but I'm fine with it, it gives me pleasure to do it and I don't care what anybody says about it ;)

Again, genuine question, what instability do you imply there is in the Windows environment? Since Win 10 I don't recall ever being fucked by updates (again, not including mandatory restarts).

What I don't like about Windows is the configuration. On Linux I can just copy over the configs and scripts from another system and that's usually that. On Windows, out of necessity, I've made a lengthy checklist of things I need to do on a new Windows machine in order to set it up to my needs. It's a pain, but once that's done I rarely have to fidget with it.

I think that my preferences have to do with getting older. When I started I happily spent days configuring Linux Desktop, compiling Gentoo with just the right flags and didn't get so upset when apt-get dist-upgrade fucked up my system. Now, I just don't care that much. I just want things to work so I can do work I want.

Just one thing to be extra clear about - I use Windows as a daily driver desktop. I'd never ever use Windows as a server, ever. I've had that experience once, in college, and I'll never ever make that mistake again ;)
Well, if someone lacks any ambitions, Europe would work, but then again more like North-Western Europe, not the eastern lands.. But otherwise it's much easier to start your company in the US in terms of red tape, funding and talent pool.. but many Americans either don't realize or fail to appreciate that.
I grew up on a Color Computer 2 (Coco 2) (Exact same specs as the Coco 1 but reduced number of chips, making it cheaper I understand). Learning to program on it as early as 7 years old got me hooked on software development. Later someone gave us a Coco 3, which was too little, too late be a market success. Still, there was something attractive about the simplicity of those old 8-bit computers.

At the end of the day, the majority of 8 bit home computers didn't have a path forward that included more powerful CPUs with advanced features and backwards compatibility and were always doomed for eventual obsoleting.
We also did a MySQL 5.7 to PG 9.6 migration (thanks to https://pgloader.io/) and we got some pretty immediate speed improvements (2-5x).

We shot ourselves in the foot a few weeks later with some poorly written RLS policies, but it was overall a smooth experience.
I would take this with a grain of salt. Research on illegal substances is highly restricted.

That said, a friend of mine developed a psychosis after using Marijuana while he was still a teenager. Although there had been cases of Psychosis in his family before, not Marijuana induced though. It stopped eventually but came back years after when he took other drugs as well combined with a very stressful life situation, things went downhill afterwards.

That's already years ago, but my understanding that I got from reading articles about this topic at the time was that this activated some sort of latent psychosis. I also read about a proposal to introduce a "Cannabis driver's license" that could be made at a pharmacy. So people would be able to check before they take it. There are also people that feel positive effects of Marijuana, me included.
I've never heard of this... seems toxic.
I think if the CCP were successful in creating race targeted bioweapons it would be in their interest to convince the world that they didn't exist.

Insults, character assassination campaigns and politicizing the existence of these bioweapons would be a good way to do that. Just copy paste some of the comments here and change the name to insult anyone who thinks they exist. They could then go and kill millions and not receive any retaliation whatsoever with people praising them for their effective program of keeping the disease epidemic they created under control. Even if you got the guy who discovered AIDS and won the Nobel prize for it to say that these were gain of function viruses that incorporated HIV protein parts, you could just launch a big propaganda campaign to attack his character.[1] Much cheaper than having to fight a war.

[1]https://www.gmanetwork.com/news/scitech/science/736458/frenc...
The issues I encountered while using MariaDB in place of MySQL were subtle -- most things worked as expected, which makes the issues so much more unexpected. But at the end of the day, the same migrations produced a different schema.

Arguably MariaDB made the correct decision to fix some MySQL 5.7 bugs that we were unwittingly relying upon, but the different behavior caused issues for us all the same.

Rather than worry about MySQL vs MariaDB and whether the one I need is packaged and available for my distro/OS of choice, I reach for Postgres on new projects.
I agree. There was a horrendous incident recently in the UK where an American woman drove the wrong way up a particular road and ran over a teenager. Somehow she was spirited out of the country and now the US refuse to extradite her.
I have seen complex macros a lot and talked with the people that made them.

Most of them just were not conscious of the consequences of their behavior. E.g this behavior is typical of someone that programs for a living but does not debug her own code, because someone else in the company does. So she is isolated from the consequences of her actions.

For making them understand it is as easy as making the debugger people to program and the programming people to debug for a while.

Nothing like making people miserable suffering from bad source code they have themselves created for making them understand.

Then you give them solutions for their misery and they learn pretty fast.

Experienced C programmers tend to avoid the trap of using heavy macros because they have learned. But at the same time they look for alternatives that make them more productive with some king of real metaprogramming.
Google pushed a one-character typo to production, bricking Chrome OS devices
A federal mandate on pay transparency would put an end to all of the unequal pay issues once and for all. What’s the downside?
Great stuff! Loved using alias to find interesting essays on crypto and videos on some other topics!
Sounds like when Fuckedcompany put itself on Fuckedcompany.
"He denies allegations that he fraudulently inflated the value of Autonomy before the sale."

Don't most startup founders fraudulently inflate the value of their startups?

"We are going after a 100 billion dollar market"

Yeah right ... only a tiny fraction of that market wants your product.
"
The material, which resembles loosely held-together concreted dust and particles, never underwent the violent cosmic collisions that most ancient space debris experienced as it smashed together to create the planets and moons of our solar system.

It doesn’t appear to have undergone thermal metamorphism, which means it’s been sitting out there, past Mars, untouched, since before any of the planets were created meaning we have the rare opportunity to examine a piece of our primordial past."

Basically, if the wording is correct, that's unusual even for meteorites.
Blizzard's full response: "The DFEH includes distorted, and in many cases false, descriptions of Blizzard’s past. We have been extremely cooperative with the DFEH throughout their investigation, including providing them with extensive data and ample documentation, but they refused to inform us what issues they perceived. They were required by law to adequately investigate and to have good faith discussions with us to better understand and to resolve any claims or concerns before going to litigation, but they failed to do so. Instead, they rushed to file an inaccurate complaint, as we will demonstrate in court. We are sickened by the reprehensible conduct of the DFEH to drag into the complaint the tragic suicide of an employee whose passing has no bearing whatsoever on this case and with no regard for her grieving family. While we find this behavior to be disgraceful and unprofessional, it is unfortunately an example of how they have conducted themselves throughout the course of their investigation. It is this type of irresponsible behavior from unaccountable State bureaucrats that are driving many of the State’s best businesses out of California."
macOS Being Picked Apart by XLoader Data Stealer
Major websites hit by global outage
A Non-Standard Model
The upsetting bit is the part where they are not living up to the expected obligation that is now the international norm as spelled out in Wassenaar arrangement -- for this category of weapons, its also the producers obligation to monitor usage and see to it that compliance with national and international laws are met.

Apart from that, I wouldnt call it a redeeming quality to ally with governments that spy on its own citizens to hold on to power.

Apart from that, I don't think Iran does anything wrong. Any other country in the same position would very likely be doing the same things for securing their own future. That they aren't in love with a nation that sabotaged their emerging organic democracy, shot down domestic airliner without any apologies forthcoming, is quite understandable. (I understand that this is off topic)

In the same spirit that you told me what I should and should not be doing, may I raise the same to you -- re-examine the moral ground for choosing the governments you ally with. I believe Saudia Arabia is one such, true champions of democracy I suppose, perhaps North Korea too going by your ex-president.
You'll have to verify this yourself, but my understanding is that there is no clear winner on the public choice issue of public vs private electrical. There are well-run and poorly-run examples on both sides.

In PG&E's defense, it's not literally cost-plus, and the CPUC doesn't always rubber stamp everything. Imagining the government alternative, what would really be different? There will still be a big bureaucratic organization full of imperfect humans with muddy incentives and limited resources. Would PG&E be better if the board of directors was appointed by politicians instead of elected by shareholders? I doubt it.
Has a US company that deals with a Chinese one be considered to have committed a crime in China if the Chinese decide they have broken one of their laws? And in such a case what are peoples feelings about extradition?
Not just TDMA - lasers in vacuum travel at the speed of light, but signals in optical fiber and coax copper are both 2/3 of that. This means that if (and that's still an if, not yet a when) starlink does laser between satellites it can beat terrestrial speeds.

I could see the end result being that we still do bent-pipe signaling over land and only laser interlinks for crossing oceans and for customers that pay for low ping to financial markets.